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Title: Pharmacographia

Authors: Friedrich August Flückiger
         Daniel Hanbury

Release Date: March 23, 2022 [eBook #67691]

Language: English

Produced by: Peter Becker and the Online Distributed Proofreading Team
             at https://www.pgdp.net

*** START OF THE PROJECT GUTENBERG EBOOK PHARMACOGRAPHIA ***





Transcriber’s Notes:

  Underscores “_” before and after a word or phrase indicate _italics_
    in the original text.
  Equal signs “=” before and after a word or phrase indicate =bold=
    in the original text.
  Small capitals have been converted to SOLID capitals.
  Illustrations have been moved so they do not break up paragraphs.
  Old or antiquated spellings have been preserved.
  Typographical and punctuation errors have been silently corrected.




                         PHARMACOGRAPHIA.

                           A HISTORY OF
                        THE PRINCIPAL DRUGS
                 OF VEGETABLE ORIGIN, MET WITH IN
                 GREAT BRITAIN AND BRITISH INDIA.

                                BY
                FRIEDRICH A. FLÜCKIGER, PHIL. DR.,
            PROFESSOR IN THE UNIVERSITY OF STRASSBURG,
                                AND
                      DANIEL HANBURY, F.R.S.,
           FELLOW OF THE LINNEAN AND CHEMICAL SOCIETIES
                            OF LONDON.

                         _SECOND EDITION._

                             _London_:
                         MACMILLAN AND CO.
                               1879.

    [_The Right of Translation and Reproduction is reserved._]




PREFACE.


PHARMACOGRAPHIA, the word which gives the title to this book, indicates
the nature of the work to which it has been prefixed. The term means
simply a _writing about drugs_; and it has been selected not without
due consideration, as in itself distinctive, easily quoted, and
intelligible in many languages.

Pharmacographia, in its widest sense, embodies and expresses the joint
intention of the authors. It was their desire, not only to write
upon the general subject, and to utilize the thoughts of others; but
that the book which they decided to produce together should contain
observations that no one else had written down. It is in fact a
record of personal researches on the principal drugs derived from the
vegetable kingdom, together with such results of an important character
as have been obtained by the numerous workers on Materia Medica in
Europe, India, and America.

Unlike most of their predecessors in Great Britain during this century,
the authors have not included in their programme either Pharmacy or
Therapeutics; nor have they attempted to give their work that diversity
of scope which would render it independent of collateral publications
on Botany and Chemistry.

While thus restricting the field of their inquiry, the authors have
endeavoured to discuss with fuller detail many points of interest which
are embraced in the special studies of the pharmacist; and at the
same time have occasionally indicated the direction in which further
investigations are desirable. A few remarks on the heads under which
each particular article is treated, will explain more precisely their
design.

The drugs included in the present work are chiefly those which are
commonly kept in store by pharmacists, or are known in the drug and
spice market of London. The work likewise contains a small number which
belong to the _Pharmacopœia of India_: the appearance of this volume
seemed to present a favourable opportunity for giving some more copious
notice of the latter than has hitherto been attempted.

Supplementary to these two groups must be placed a few substances which
possess little more than historical interest, and have been introduced
rather in obedience to custom, and for the sake of completeness, than
on account of their intrinsic value.

Each drug is headed by the Latin name, followed by such few synonyms as
may suffice for perfect identification, together in most cases with the
English, French, and German designation.

In the next section, the _Botanical Origin_ of the substance is
discussed, and the area of its growth, or locality of its production is
stated. Except in a few instances, no attempt has been made to furnish
botanical descriptions of the plants to which reference is made. Such
information may readily be obtained from original and special sources,
of which we have quoted some of the most important.

Under the head of _History_, the authors have endeavoured to trace the
introduction of each substance into medicine, and to bring forward
other points in connection therewith, which have not hitherto been
much noticed in any recent work. This has involved researches which
have been carried on for several years, and has necessitated the
consultation of many works of general literature. The exact titles
of these works have been scrupulously preserved, in order to enable
the reader to verify the statements made, and to prosecute further
historical inquiries. In this portion of their task, the authors have
to acknowledge the assistance kindly given them by Professors Heyd[1]
of Stuttgart, Winkelmann of Heidelberg, Monier Williams of Oxford,
Dümichen of Strassburg; and on subjects connected with China, by Mr. A.
Wylie and Dr. Bretschneider. The co-operation in various directions of
many other friends has been acknowledged in the text itself.

[1] The admirable work of this author—_Geschichte des Levantehandels im
Mittelalter_, 2 vols., Stuttgart, 1879—appeared when the second edition
of our Pharmacographia was already in the press.

In some instances the _Formation_, _Secretion_, or _Method of
Collection_ of a drug, has been next detailed: in others, the section
_History_ has been immediately followed by the _Description_, succeeded
by one in which the more salient features of _Microscopic Structure_
have been set forth. The authors have not thought it desirable to
amplify the last named section, as the subject deserves to be treated
in a special work, and to be illustrated by engravings. Written
descriptions of microscopic structure are tedious and uninteresting,
and however carefully drawn up, must often fail to convey the true
meaning which would be easily made evident by the pencil. The reader
who wishes for illustrations of the minute structure of drugs may
consult the works named in the footnote.[2]

The next division includes the important subject of _Chemical
Composition_, in which the authors have striven to point out to the
reader familiar with chemistry what are the constituents of greatest
interest in each particular drug—what the characters of the less
common of those constituents—and by whom and at what date the chief
investigations have been made. A knowledge of the name and date
provides a clue to the original memoir, which may usually be found,
either _in extenso_ or in abstract, in more than one periodical.
It has been no part of the authors’ plan to supersede reference to
standard works on chemistry, or to describe the chemical character of
substances[3] which may be easily ascertained from those sources of
information which should be within the reach of every pharmaceutical
inquirer.

In the section devoted to _Production and Commerce_, the authors
have given such statistics and other trade information as they could
obtain from reliable sources; but they regret that this section is
of very unequal value. Duties have been abolished, and a general and
continuous simplification of tariffs and trade regulations has ensued.
The details, therefore, that used to be observed regarding the commerce
in drugs, exists no longer in anything like their former state of
completeness: hence the fragmentary nature of much of the information
recorded under this head.

The medicinal uses of each particular drug are only slightly mentioned,
it being felt that the science of therapeutics lies within the province
of the physician, and may be wisely relinquished to his care. At the
same time it may be remarked that the authors would have rejoiced had
they been able to give more definite information as to the technical or
economic uses of some of the substances they have described.

[2] Berg, _Anatomischer Atlas zur pharmazeutischen Waarenkunde_,
Berlin, 1865. 4to., with 50 plates.

Flückiger, _Grundlagen der pharmaceutischen Waarenkunde, Einleitung in
das Studium der Pharmacognosie_, Berlin, 1873.

Planchon, _Traité pratique de la détermination des drogues simples
d’origine végétale_, Paris, 1874.

Luerssen, _Medicinisch-Pharmaceutische Botanik_, Leipzig (in progress).

[3] For further information, see Flückiger, _Pharmaceutische Chemie_,
Berlin, 1879.

What has been written under the head of _Adulteration_ is chiefly
the result of actual observation, or might otherwise have been much
extended. The authors would rather rely on the characters laid down in
preceding sections than upon empirical methods for the determination
of purity. The heading of _Substitutes_ has been adopted for certain
drugs, more or less related to those described in special articles, yet
not actually used by way of adulteration.

A work professing to bring together the latest researches in any
subject will naturally be thought to contain needless innovations.
Whilst deprecating the inconvenience of changes of nomenclature, the
authors have had no alternative but to adopt the views sanctioned by
the leaders of chemical and botanical science, and which the progress
of knowledge has required. The common designations of drugs may indeed
remain unchanged:—hellebore, aconite, colchicum, anise, and caraway,
need no modernizing touch. But when we attempt to combine with these
simple names, words to indicate the organ of the plant of which they
are constituted, questions arise as to the strict application of such
terms as root, rhizome, tuber, corm, about which a diversity of opinion
may be entertained.

It has been the authors’ aim to investigate anew the field of Vegetable
Materia Medica, in order as far as possible to clear up doubtful
points, and to remove some at least of the uncertainties by which the
subject is surrounded. In furtherance of this plan they have availed
themselves of the resources offered by Ancient and Modern History; nor
have they hesitated to lay under contribution either the teaching of
men eminent in science, or the labours of those who follow the paths of
general literature. How far they have accomplished their desire remains
for the public to decide.


CORRIGENDA.

    Page  57, footnote 4; _for_ qui produit,
                          _read_ qui a produit.
      ”   86, 13th line from bottom; _for_ Bauchin,
                                     _read_ Bauhin.
      ”  128, footnote 3; _read_ Adversariorum,
                          _for_ Adersariorum.
      ”  161, line from top; _read_ southern and south-western
                       part, _for_ northern part.
      ”  265, footnote 2; _for_ 4794 grammes,
                          _read_ 4·794 grammes.
      ”  271, line 5 from bottom; _read_ στνραξ νγρὸϛ
                                  _for_ πνρα ζνγρὸϛ.
      ”  368, line 12 from bottom; _read_ Flora, _for_ Floræ.
      ”   ”     ”  20          ”      ”   mossing, _for_ motsing.
      ”  369,   ”  17 from top; _read_ José, _for_ Jose.
      ”  404,   ”   2 from bottom; _read_ Xarnauz,
                                   _for_ Xarnaux.
      ”   ”   footnote 7; _read_ por, _for_ par.
      ”   ”   line 12 from bottom; _read_ Barbarigo,
                                   _for_ Barberigo.
      ”  407,   ”   5         ”       ”   benzoic, _for_ benzoin.
      ”  469, lines 21 and 24 from top; with reference to _Nicotiana
              rustica_ and _N. repanda_,
              see _Pharm. Journ._ ix. (1878) 710.
      ”  558, footnote 3; _read_ 562, _for_ 652.
      ”  559, line 24 from top; _read_ 1849, _for_ 1749.




PREFACE TO THE SECOND EDITION.


The premature death—March 24, 1875—of my lamented friend Daniel
Hanbury, having deprived me of his invaluable assistance, I have
attempted to prepare the new edition of our work with adherence to the
same principles by which we were guided from the beginning.

I desire to acknowledge my obligations for great and valuable
assistance to my friend Thomas Hanbury, Esq., F.L.S., who has also
honoured the memory of his late brother by causing the scientific
researches of the latter to be collected and republished in the
handsome volume entitled, “Science Papers, chiefly Pharmacological
and Botanical, by Daniel Hanbury, edited, with memoir, by Joseph
Ince,” London. 1876. To Dr. Charles Rice of New York, editor of
“New Remedies,” I am indebted for much kindly extended and valuable
information, and to whose intimate acquaintance with oriental
literature, both ancient and modern, many of the following pages bear
ample testimony. I am likewise indebted for similar assistance to my
friends Professors Goldschmidt and Nöldeke, Strassburg. Information of
various kinds, as well as valuable specimens of drugs, have also been
courteously supplied to me by the following gentlemen, viz.:—Cesar
Chantre, Esq., F.L.S., London; Prof. Dymock, Bombay; H. Fritzsche, Esq.
(Schimmel &, Leipzig); E. M. Holmes, Esq., F.L.S., &c., London; J. E.
Howard, Esq., F.R.S., &c., London; David Howard, Esq., F.C.S., &c.;
Wm. Dillworth Howard, F.I.C., London; Capt. F. M. Hunter, F.G.S., &c.,
Assistant Resident, Aden; A. Oberdörffer, Esq., Hamburg; Prof. Edward
Schär, Zürich; Dr. J. E. de Vry, the Hague, &c.

On mature consideration, it was deemed expedient to omit in the new
edition a large number of references relating more especially to
chemical facts. Yet, in most instances, not only the author but
also the year has been stated in which the respective observation or
discovery was made, or at least the year in which it was published
or recorded. Every such fact of any importance may thus, by means of
those short references, be readily traced and consulted, if wished
for, either in the original sources, in abstracts therefrom, or in the
periodical reports. Opportunities of the latter kind are abundantly
afforded by the German _Jahresbericht der Pharmacie_, &c., published at
Göttingen since 1844, successively by Martius, Wiggers, Husemann, and
at the present time by Dragendorff. The same may be said, since 1857,
of the _Report on the Progress of Pharmacy_, as contained annually
in the Proceedings of the American Pharmaceutical Association, and
likewise, since 1870, of the _Yearbook of Pharmacy_, for which the
profession is indebted to the British Pharmaceutical Conference.

                                                   PROF. FLÜCKIGER.
    STRASSBURG, GERMANY, _October, 1879_.




EXPLANATIONS.


=Polarization.=—Most essential oils, and the solutions of several
substances described in this book are capable of effecting the
deviation of a ray of polarized light. The amount of this rotatory
power cannot be regarded as constant in essential oils, and is
greatly influenced by various causes. As to alkaloids and other
organic compounds, the deviation frequently depends upon the nature
and quantity of the solvent. The authors have thought it needful to
record in numerous cases the results of such optical investigations,
as determined by means of the _Polaristrobometer_ invented by Wild,
and described in Poggendorff’s _Annalen der Physik und Chemie_, vol.
122 (1864) p. 626; or more completely in the _Bulletin de l’Académie
impériale des Sciences de St. Pétersbourg_, tome viii. (1869) p. 33.

[Illustration]

=Measurements and Weights.=—The authors regret to have been unable to
adopt one standard system of stating measurements. They have mostly
employed the English inch: the accompanying woodcut will facilitate
its comparison with the French decimal scale. The word _millimetre_
is indicated in the text by the contraction _mm._; _micromillimetre_,
signifying the thousandth part of a millimetre, and only used in
reference to the microscope, is abbreviated thus, _mkm._

    1 inch              =   25·399 millimetres.
    1 gallon            =    4·543 litres.
    1 ounce (oz.) avdp. =   28·34 grammes.
    1 lb. avoirdupois   =  453·59    ”
    1 cwt.              =  112 lb. = 50·8 kilogrammes.
    1 ton               = 2240  ”  = 1016     ”
    1 kilogramme        =    2·204 lb. avoirdupois.
    1 pecul             =  133·33 lb.   =   60·479 kilogrammes.

=Thermometer.=—The _Centigrade Thermometer_ has been alone adopted. The
following table is given _for comparing the degrees of the Centigrade
or Celsius Thermometer with those of Fahrenheit’s Scale_.


THERMOMETRIC TABLE.

    --------------+----------------+-----------------+---------------
    CENT.   FAHR. | CENT.   FAHR.  |  CENT.   FAHR.  |  CENT.   FAHR.
    --------------+----------------+-----------------+---------------
     -29°  -20·2° | + 41° + 105·8° |  +111   +231·8  |  +181   +357·8
      28    18·4  |   42    107·6  |   112    233·6  |   182    359·6
      27    16·6  |   43    109·4  |   113    235·4  |   183    361·4
      26    14·8  |   44    111·2  |   114    237·2  |   184    363·2
      25    13·0  |   45    113·0  |   115    239·0  |   185    365·0
      24    11·2  |   46    114·8  |   116    240·8  |   186    366·8
      23     9·4  |   47    116·6  |   117    242·6  |   187    368·6
      22     7·6  |   48    118·4  |   118    244·4  |   188    370·4
      21     5·8  |   49    120·2  |   119    246·2  |   189    372·2
      20     4·0  |   50    122·0  |   120    248·0  |   190    374·0
                  |                |                 |
      19     2·2  |   51    123·8  |   121    249·8  |   191    375·8
      18    -0·4  |   52    125·6  |   122    251·6  |   192    377·6
      17    +1·4  |   53    127·4  |   123    253·4  |   193    379·4
      16     3·2  |   54    129·2  |   124    255·2  |   194    381·2
      15     5·0  |   55    131·0  |   125    257·0  |   195    383·0
      14     6·8  |   56    132·8  |   126    258·8  |   196    384·8
      13     8·6  |   57    134·6  |   127    260·6  |   197    386·6
      12    10·4  |   58    136·4  |   128    262·4  |   198    388·4
      11    12·2  |   59    138·2  |   129    264·2  |   199    390·2
      10    14·0  |   60    140·0  |   130    266·0  |   200    392·0
                  |                |                 |
       9    15·8  |   61    141·8  |   131    267·8  |   201    393·8
       8    17·6  |   62    143·6  |   132    269·6  |   202    395·6
       7    19·4  |   63    145·4  |   133    271·4  |   203    397·4
       6    21·2  |   64    147·2  |   134    273·2  |   204    399·2
       5    23·0  |   65    149·0  |   135    275·0  |   205    401·0
       4    24·8  |   66    150·8  |   136    276·8  |   206    402·8
       3    26·6  |   67    152·6  |   137    278·6  |   207    404·6
       2    28·4  |   68    154·4  |   138    280·4  |   208    406·4
      -1    30·2  |   69    156·2  |   139    282·2  |   209    408·2
       0    32·0  |   70    158·0  |   140    284·0  |   210    410·0
                  |                |                 |
      +1    33·8  |   71    159·8  |   141    285·8  |   211    411·8
       2    35·6  |   72    161·6  |   142    287·6  |   212    413·6
       3    37·4  |   73    163·4  |   143    289·4  |   213    415·4
       4    39·2  |   74    165·2  |   144    291·2  |   214    417·2
       5    41·0  |   75    167·0  |   145    293·0  |   215    419·0
       6    42·8  |   76    168·8  |   146    294·8  |   216    420·8
       7    44·6  |   77    170·6  |   147    296·6  |   217    422·6
       8    46·4  |   78    172·4  |   148    298·4  |   218    424·4
       9    48·2  |   79    174·2  |   149    300·2  |   219    426·2
      10    50·0  |   80    176·0  |   150    302·0  |   220    428·0
                  |                |                 |
      11    51·8  |   81    177·8  |   151    303·8  |   221    429·8
      12    53·6  |   82    179·6  |   152    305·6  |   222    431·6
      13    55·4  |   83    181·4  |   153    307·4  |   223    433·4
      14    57·2  |   84    183·2  |   154    309·2  |   224    435·2
      15    59·0  |   85    185·0  |   155    311·0  |   225    437·0
      16    60·8  |   86    186·8  |   156    312·8  |   226    438·8
      17    62·6  |   87    188·6  |   157    314·6  |   227    440·6
      18    64·4  |   88    190·4  |   158    316·4  |   228    442·4
      19    66·2  |   89    192·2  |   159    318·2  |   229    444·2
      20    68·0  |   90    194·0  |   160    320·0  |   230    446·0
                                                     |
      21    69·8  |   91    195·8  |   161    321·8  |   231    447·8
      22    71·6  |   92    197·6  |   162    323·6  |   232    449·6
      23    73·4  |   93    199·4  |   163    325·4  |   233    451·4
      24    75·2  |   94    201·2  |   164    327·2  |   234    453·2
      25    77·0  |   95    203·0  |   165    329·0  |   235    455·0
      26    78·8  |   96    204·8  |   166    330·8  |   236    456·8
      27    80·6  |   97    206·6  |   167    332·6  |   237    458·6
      28    82·4  |   98    208·4  |   168    334·4  |   238    460·4
      29    84·2  |   99    210·2  |   169    336·3  |   239    462·2
      30    86·0  |  100    212·0  |   170    338·0  |   240    464·0
                  |                |                 |
      31    87·8  |  101    213·8  |   171    339·8  |   241    465·8
      32    89·6  |  102    215·6  |   172    341·6  |   242    467·6
      33    91·4  |  103    217·4  |   173    343·4  |   243    469·4
      34    93·2  |  104    219·2  |   174    345·2  |   244    471·2
      35    95·0  |  105    221·0  |   175    347·0  |   245    473·0
      36    96·8  |  106    222·8  |   176    348·8  |   246    474·8
      37    98·6  |  107    224·6  |   177    350·6  |   247    476·6
      38   100·4  |  108    226·4  |   178    352·4  |   248    478·4
      39   102·2  |  109    228·2  |   179    354·2  |   249    480·2
      40   104·0  |  110    230·0  |   180    356·0  |   250    482·0
    --------------+----------------+-----------------+-----------------




CONTENTS.


                                                 PAGE
    PREFACE                                        v
    PREFACE TO THE SECOND EDITION                 ix
    EXPLANATIONS                                  xi
    THERMOMETRIC TABLE                           xii

         I.—PHÆNOGAMOUS OR FLOWERING PLANTS.

       =_Dicotyledons and Gymnosperms._=

    RANUNCULACEÆ                                   1
      Radix Hellebori nigri                        1
      Rhizoma Coptidis                             3
      Semen Staphisagriæ                           5
      Radix Aconiti                                8
      Folia Aconiti                               11
      Radix Aconiti indica                        12
      ——— heterophylli                            14
      ——— Cimicifugæ                              15

    MAGNOLIACEÆ                                   17
      Cortex Winteranus                           17
      Fructus Anisi stellati                      20

    MENISPERMACEÆ                                 23
      Radix Calumbæ                               23
      Pareira Brava                               25
      Cocculus indicus                            31
      Gulancha                                    33

    BERBERIDEÆ                                    34
      Cortex Berberidis indicus                   34
      Rhizoma Podophylli                          36

    PAPAVERACEÆ                                   39
      Petala Rhœados                              39
      Capsulæ Papaveris                           40
      Opium                                       42

    CRUCIFERÆ                                     64
      Semen Sinapis nigræ                         64
      ———— albæ                                   68
      Radix Armoraciæ                             71

    CANELLACEÆ                                    73
      Cortex Canellæ albæ                         73

    BIXACEÆ                                       75
      Semen Gynocardiæ                            75

    POLYGALEÆ                                     77
      Radix Senegæ                                77
      ——— Krameriæ                                79

    GUTTIFERÆ                                     83
      Cambogia                                    83
      Oleum Garciniæ                              86

    DIPTEROCARPEÆ                                 88
      Balsamum Dipterocarpi                       88

    MALVACEÆ                                      92
      Radix Althææ                                92
      Fructus Hibisci esculenti                   94

    STERCULIACEÆ                                  95
      Oleum Cacao                                 95

    LINEÆ                                         97
      Semen Lini                                  97

    ZYGOPHYLLEÆ                                  100
      Lignum Guaiaci                             100
      Resina Guaiaci                             103

    RUTACEÆ                                      106
      Cortex Angosturæ                           106
      Folia Buchu                                108
      Radix Toddaliæ                             111
      Folia Pilocarpi                            113

    AURANTIACEÆ                                  114
      Fructus Limonis                            114
      Oleum Limonis                              118
      ——— Bergamottæ                             121
      Cortex Aurantii                            124
      Oleum Neroli                               126
      Fructus Belæ                               129

    SIMARUBEÆ                                    131
      Lignum Quassiæ                             131

    BURSERACEÆ                                   133
      Olibanum                                   133
      Myrrha                                     140
      Elemi                                      147

    MELIACEÆ                                     154
      Cortex Margosæ                             154
      ——— Soymidæ                                156

    RHAMNACEÆ                                    157
      Fructus Rhamni                             157

    AMPELIDEÆ                                    159
      Uvæ passæ                                  159

    ANACARDIACEÆ                                 161
      Mastiche                                   161
      Terebinthina chia                          165
      Gallæ chinenses seu japonicæ               167

    LEGUMINOSÆ                                   170
      Herba Scoparii                             170
      Semen Fœni græci                           172
      Tragacantha                                174
      Radix Glycyrrhizæ                          179
      Succus Glycyrrhizæ                         183
      Oleum Arachis                              186
      Radix Abri                                 188
      Setæ Mucunæ                                189
      Semen Physostigmatis                       191
      Kino                                       194
      Lignum Pterocarpi                          199
      Balsamum tolutanum                         202
      ——— peruvianum                             205
      Semen Bonducellæ                           211
      Lignum Hæmatoxyli                          213
      Folia Sennæ                                216
      Fructus Cassiæ Fistulæ                     221
      Tamarindi Pulpa                            224
      Balsamum Copaiba                           227
      Gummi Acaciæ                               233
      Catechu                                    240

    ROSACEÆ                                      244
      Amygdalæ dulces                            244
      ——— amaræ                                  247
      Fructus Pruni                              251
      Cortex Pruni serotinæ                      253
      Folia Lauro-cerasi                         254
      Flores Koso                                256
      Petala Rosæ gallicæ                        259
      ——— centifoliæ                             261
      Oleum Rosæ                                 262
      Fructus Rosæ caninæ                        268
      Semen Cydoniæ                              269

    HAMAMELIDEÆ                                  271
      Styrax liquidus                            271

    MYRTACEÆ                                     277
      Oleum Cajaputi                             277
      Caryophylli                                280
      Fructus Pimentæ                            287

    GRANATEÆ                                     289
      Cortex Granati fructus                     289
      ———— radicis                               290

    CUCURBITACEÆ                                 292
      Fructus Ecballii                           292
      ——— Colocynthidis                          295

    UMBELLIFERÆ                                  297
      Herba Hydrocotyles                         297
      Fructus Conii                              299
      Folia Conii                                301
      Fructus Ajowan                             302
      ——— Carui                                  304
      ——— Fœniculi                               308
      ——— Anisi                                  310
      Radix Sumbul                               312
      Asafœtida                                  314
      Galbanum                                   320
      Ammoniacum                                 324
      Fructus Anethi                             327
      ——— Coriandri                              329
      ——— Cumini                                 331

    CAPRIFOLIACEÆ                                333
      Flores Sambuci                             333

    RUBIACEÆ                                     335
      Gambier                                    335
      Cortex Cinchonæ                            338
      Radix Ipecacuanhæ                          370

    VALERIANACEÆ                                 377
      Radix Valerianæ                            377

    COMPOSITÆ                                    380
      Radix Inulae                               380
      ——— Pyrethri                               383
      Flores Anthemidis                          384
      Santonica                                  387
      Radix Arnicæ                               390
      Flores Arnicæ                              392
      Radix Taraxaci                             392
      Herba Lactucæ virosæ                       395
      Lactucarium                                396

    LOBELIACEÆ                                   399
      Herba Lobeliæ                              399

    ERICACEÆ                                     401
      Folia Uvæ Ursi                             401

    EBENACEÆ                                     403
      Fructus Diospyri                           403

    STYRACEÆ                                     403
      Resina Benzoë                              403

    OLEACEÆ                                      409
      Manna                                      409
      Oleum Olivæ                                417

    APOCYNEÆ                                     421
      Cortex Alstoniæ                            421

    ASCLEPIADEÆ                                  423
      Radix Hemidesmi                            423
      Cortex Mudar                               424
      Folia Tylophoræ                            427

    LOGANIACEÆ                                   428
      Nux Vomica                                 428
      Semen Ignatii                              431
      Radix Spigeliæ                             433

    GENTIANEÆ                                    434
      Radix Gentianæ                             434
      Herba Chiratæ                              436

    CONVOLVULACEÆ                                438
      Scammonium                                 438
      Radix Jalapæ                               443
      Semen Kaladanæ                             448

    SOLANACEÆ                                    450
      Stipes Dulcamaræ                           450
      Fructus Capsici                            452
      Radix Belladonnæ                           455
      Folia Belladonnæ                           458
      Herba Stramonii                            459
      Semen Stramonii                            461
      ——— et Folia Daturæ albæ                   462
      Folia Hyoscyami                            463
      ——— Tabaci                                 466

    SCROPHULARIACEÆ                              469
      Folia Digitalis                            469

    ACANTHACEÆ                                   472
      Herba Andrographidis                       472

    SESAMEÆ                                      473
      Oleum Sesami                               473

    LABIATÆ                                      476
      Flores Lavandulæ                           476
      Herba Menthæ viridis                       479
      ——— piperitæ                               481
      ——— Pulegii                                486
      ——— Thymi                                  487
      ——— Rosmarini                              488

    PLANTAGINEÆ                                  490
      Semen Ispaghulæ                            490

    POLYGONACEÆ                                  491
      Radix Rhei                                 491

    MYRISTICEÆ                                   502
      Myristica                                  502
      Macis                                      508

    LAURACEÆ                                     510
      Camphora                                   510
      Cortex Cinnamomi                           519
      ——— Cassiæ ligneæ                          527
      ——— Bibiru                                 535
      Radix Sassafras                            537

    THYMELEÆ                                     540
      Cortex Mezerei                             540

    ARTOCARPACEÆ                                 542
      Caricæ                                     542

    MORACEÆ                                      544
      Fructus Mori                               544

    CANNABINEÆ                                   546
      Herba Cannabis                             546
      Strobili Humuli                            551
      Glandulæ Humuli                            554

    ULMACEÆ                                      556
      Cortex Ulmi                                556
      ——— fulvæ                                  557

    EUPHORBIACEÆ                                 558
      Euphorbium                                 558
      Cortex Cascarillæ                          561
      Semen Tiglii                               565
      ——— Ricini                                 567
      Kamala                                     572

    PIPERACEÆ                                    576
      Fructus Piperis nigri                      576
      ——— longi                                  582
      Cubebæ                                     584
      Herba Matico                               589

    ARISTOLOCHIACEÆ                              591
      Radix Serpentariæ                          591

    CUPULIFERÆ                                   593
      Cortex Quercus                             593
      Gallæ halepenses                           595

    SANTALACEÆ                                   599
      Lignum Santali                             599

         =_Gymnosperms._=

    CONIFERÆ                                     604
      Terebinthina vulgaris                      604
      ——— veneta                                 609
      Cortex Laricis                             611
      Terebinthina canadensis                    612
      ——— argentoratensis                        615
      Pix burgundica                             616
      ——— liquida                                619
      ——— nigra                                  623
      Fructus Juniperi                           624
      Herba Sabinæ                               626

         =_Monocotyledons._=

    CANNACEÆ                                     629
      Amylum Marantæ                             629

    ZINGIBERACEÆ                                 635
      Rhizoma Zingiberis                         635
      ——— Carcumæ                                638
      ——— Galangæ                                641
      Fructus Cardamomi                          643
      Grana Paradisi                             651

    ORCHIDACEÆ                                   654
      Salep                                      654
      Vanilla                                    657

    IRIDACEÆ                                     660
      Rhizoma Iridis                             660
      Crocus                                     663

    PALMÆ                                        669
      Semen Arecæ                                669
      Sanguis Draconis                           672

    AROIDEÆ                                      676
      Rhizoma Calami aromatici                   676

    LILIACEÆ                                     679
      Aloë                                       679
      Bulbus Scillæ                              690

    MELANTHACEÆ                                  693
      Rhizoma Veratri albi                       693
      ——— viridis                                695
      Semen Sabadillæ                            697
      Cormus Colchici                            699
      Semen Colchici                             702

    SMILACEÆ                                     703
      Radix Sarsaparillæ                         703
      Tuber Chinæ                                712

    GRAMINEÆ                                     714
      Saccharum                                  714
      Hordeum decorticatum                       722
      Oleum Andropogonis                         725
      Rhizoma Graminis                           729

         II.—CRYPTOGAMOUS OR FLOWERLESS PLANTS.

         =_Vascular Cryptogams._=
    LYCOPODIACEÆ                                 731
      Sporæ Lycopodii                            731

    FILICES                                      733
      Rhizoma Filicis                            733

          =_Thallogens._=

    LICHENES                                     737
      Lichen islandicus                          737

    FUNGI                                        740
      Secale cornutum                            740

    ALGÆ (FLORIDEÆ)                              747
      Chondrus crispus                           747
      Fucus amylaceus                            749

                APPENDIX.
    Short Biographic and Bibliographic Notes
    relating to authors and books quoted in
    the Pharmacographia                          751

    INDEX                                        769




PHARMACOGRAPHIA.




I.—PHÆNOGAMOUS OR FLOWERING PLANTS.


_Dicotyledons and Gymnosperms._


RANUNCULACEÆ.


RADIX HELLEBORI NIGRI.

    _Radix Ellebori nigri_, _Radix Melampodii_; _Black
           Hellebore Root_; F. _Racine d’Ellebore noir_;
           G. _Schwarze Nieswurzel_.

=Botanical Origin=—_Helleborus niger_ L., a low perennial herb, native
of sub-alpine woods in Southern and Eastern Europe. It is found in
Provence, Northern Italy, Salzburg, Bavaria, Austria, Bohemia, and
Silesia, as well as, according to Boissier,[4] in Continental Greece.

Under the name of _Christmas Rose_, it is often grown in English
gardens on account of its handsome white flowers, which are put forth
in midwinter.

=History=—The story of the daughters of Prœtus, king of Argos, being
cured of madness by the soothsayer and physician Melampus, who
administered to them hellebore, has imparted great celebrity to the
plant under notice.[5]

But admitting that the medicine of Melampus was really the root of a
species of _Helleborus_, its identity with that of the present plant
is extremely improbable. Several other species grow in Greece and
Asia Minor, and Schroff[6] has endeavoured to show that of these,
_H. orientalis_ Lam. possesses medicinal powers agreeing better with
the ancient accounts than those of _H. niger_ L. He has also pointed
out that the ancients employed not the entire root but only the bark
separated from the woody column; and that in _H. niger_ and _H.
viridis_ the peeling of the rhizome is impossible, but that in _H.
orientalis_ it may be easily effected.

[4] _Flora Orientalis_, i. (1867) 61.

[5] See the list of theses and memoirs on Hellebore given by Mérat and
De Lens, _Dict._ iii. (1831) 472, 473.

[6] _Zeitschr. d. Gesellsch. d. Aerzte zu Wien._ 1860, No. 25;
Canstatt’s _Jahresbericht_ for 1859. i. 47. 1860. i. 55.

According to the same authority the hellebores differ extremely in
their medicinal activity. The most potent is _H. orientalis_ Lam.;
then follow _H. viridis_ L. and _H. fœtidus_ L. (natives of Britain),
and _H. purpurascens_ Waldst. et Kit., a Hungarian species, while _H.
niger_ is the weakest of all.[7]

=Description=—Black Hellebore produces a knotty, fleshy, brittle
rhizome which creeps and branches slowly, forming in the course of
years an intangled, interlacing mass, throwing out an abundance of
stout, straight roots. Both rhizome and roots are of a blackish brown,
but the younger roots are of lighter tint and are covered with a short
woolly tomentum.

In commerce the rhizome is found with the roots more or less broken
off and detached. It is in very knotty irregular pieces, 1 to 2 or 3
inches long and about ²/₁₀ to ³/₁₀ of an inch in diameter, internally
whitish and of a horny texture. If cut transversely (especially after
maceration), it shows a circle of white woody wedges, 8 to 12 in
number, surrounded by a thick bark. The roots are unbranched, scarcely
⅒ of an inch in diameter. The younger, when broken across, exhibit a
thick bark encircling a simple woody cord; in the older this cord tends
to divide into converging wedges which present a stellate appearance,
though not so distinctly as in _Actæa_. The drug when cut or broken has
a slight odour like that of senega. Its taste is bitterish and slightly
acrid.

=Microscopic Structure=—The cortical part both of the rhizome and the
rootlets exhibits no distinct medullary rays. In the rootlets the woody
centre is comparatively small and enclosed by a narrow zone somewhat as
in sarsaparilla. A distinct pith occurs in the rhizome but not always
in the rootlets, their woody column forming one solid bundle or being
divided into several. The tissue contains small starch granules and
drops of fatty oil.

=Chemical Composition=—The earlier investigations of Black Hellebore
by Gmelin, and Feneuille and Capron, and of Riegel indicated only the
presence of the more usual constituents of plants.

Bastick, on the other hand, in 1852 obtained from the root a peculiar,
non-volatile, crystalline, chemically-indifferent substance which he
named _Helleborin_. It is stated to have a bitter taste and to produce
in addition a tingling sensation on the tongue; to be slightly soluble
in water, more so in ether, and to dissolve freely in alcohol.

Marmé and A. Husemann extracted helleborin (1864) by treating with hot
water the green fatty matter which is dissolved out of the root by
boiling alcohol. After recrystallization from alcohol, it is obtainable
in shining, colourless needles, having the composition C₃₆H₄₂O₆. It is
stated to be highly narcotic. Helleborin appears to be more abundant
in _H. viridis_ (especially in the older roots) than in _H. niger_,
and yet to be obtainable only to the extent of 0·4 per mille. When it
is boiled with dilute sulphuric acid, or still better with solution of
zinc chloride, it is converted into sugar and _Helleboresin_, C₃₀H₃₈O₄.

[7] Between _purpurascens_ and _niger_, Schroff places _L. ponticus_ A.
Br., a plant which Boissier holds to be simply _H. orientalis_ Lam.

Marmé and Husemann succeeded in isolating other crystallized
principles from the leaves and roots of _H. niger_ and _H. viridis_,
by precipitation with phospho-molybdic acid. They obtained firstly a
slightly acid glucoside which they named _Helleboreïn_. It occurs only
in very small proportion, but is rather more abundant in _H. niger_
than in _H. viridis_. When boiled with a dilute acid, helleboreïn,
C₂₆H₄₄O₁₅, is resolved into _Helleboretin_, C₁₄H₂₀O₃, of a fine violet
colour, and sugar, C₁₂H₂₄O₁₂. It is remarkable that helleboretin has no
physiological action, though helleboreïn is stated to be poisonous.

An organic acid accompanying helleborin was regarded by Bastick as
probably aconitic (equisetic) acid. There is no tannin in hellebore.

=Uses=—Black Hellebore is reputed to be a drastic purgative. In British
medicine its employment is nearly obsolete, but the drug is still
imported from Germany and sold for the use of domestic animals.

=Adulteration=—Black Hellebore root as found in the market is not
always to be relied on, and without good engravings it is not easy to
point out characters by which its genuineness can be made certain. In
fact to ensure its recognition, some pharmacopœias required that it
should be supplied with leaves attached.

The roots with which it is chiefly liable to be confounded are the
following:—

1. _Helleborus viridis_ L.—Although a careful comparison of
authenticated specimens reveals certain small differences between the
roots and rhizomes of this species and of _H. niger_, there are no
striking characters by which they can be discriminated. The root of
_H. viridis_ is far more bitter and acrid than that of _H. niger_, and
it exhibits more numerous drops of fatty oil. In German trade the two
drugs are supplied separately, both being in use; but as _H. viridis_
is apparently the rarer plant and its root is valued at 3 to 5 times
the price of that of _H. niger_, it is not likely to be used for
sophisticating the latter.

2. _Actœa spicata_ L.—In this plant the rhizome is much thicker; the
rootlets broken transversely display a cross or star, as figured in
Flückiger’s “Grundlagen” (see p. vii.), fig. 64, p. 76. The drug has
but little odour; as it contains tannin its infusion is blackened by
a persalt of iron, which is not the case with an infusion of Black
Hellebore.


RHIZOMA COPTIDIS.

_Radix Coptidis_; _Coptis Root_, _Mishmi Bitter_, _Mishmi Tita_.

=Botanical Origin=—_Coptis Teeta_ Wallich, a small herbaceous plant,
still but imperfectly known, indigenous to the Mishmi mountains,
eastward of Assam. It was first described in 1836 by Wallich.[8]

=History=—This drug under the name of _Mahmira_ is used in Sind for
inflammation of the eyes, a circumstance which enabled Pereira[9] to
identify it with a substance bearing a nearly similar designation,
mentioned by the early writers on medicine, and previously regarded as
the root of _Chelidonium majus_ L.

[8] _Trans. of Med. and Phys. Soc. of Calcutta_, viii. (1836) 85.
Reprinted in _Pereira’s_ Materia Medica, vol ii. part 2 (1857), 699.

[9] _Pharm. Journ._ xi. (1852) 204; also _Mat. Med. l.c._

Thus we find that Paulus Ægineta in the 7th century was acquainted
with a knotty root named Μαηιρά.[10] Rhazes, who according to Choulant
died in A.D. 923 or 932, mentions _Mamiran_, and it is also noticed
by Avicenna a little later as a drug useful in diseases of the eye.
Μαμιρὰϛ likewise occurs in exactly the same way in the writings of
_Leo_, “Philosophus et Medicus.”[11] Ibn Baytar called the drug
_Mamiran_ and _Uruk_, and described it as a small yellow root like
turmeric, coming from China. Other writers of the middle ages allude to
it under the name of _Memeren_.

Hajji Mahomed, in the account of Cathay which he gave to Ramusio
(_circa_ A.D. 1550) says that the _Mambroni chini_, by which we
understand the root in question, is found in the mountains of Succuir
(Suh-cheu) where rhubarb grows, and that it is a wonderful remedy for
diseases of the eye.[12] In an official report published at Lahore in
1862,[13] _Mamiran-i-chini_ is said to be brought from China to Yarkand.

The rhizome of _Coptis_ is used by the Chinese under the names
_Hwang-lien_ and _Chuen-lien_.[14] It is enumerated by Cleyer[15]
(1682) as “_radix pretiosa amara_,” and was described in 1778 by
Bergius[16] who received it from Canton.

More recently it was the subject of an interesting notice by
Guibourt[17] who thought it to be derived from _Ophioxylon serpentinum_
L., an apocyneous plant widely removed from _Coptis_. Its root was
recommended in India by MacIsaac[18] in 1827 and has been subsequently
employed with success by many practitioners.

There is a rude figure of the plant in the Chinese herbal _Pun-tsao_.

=Description=—_Tita_, as the drug is called in the Mishmi country,
whence it is sent by way of Sudiya on the Bramaputra to Bengal, is a
rhizome about the thickness of a quill occurring in pieces an inch or
two in length. It often branches at the crown into two or three heads,
and bears the remains of leafstalks and thin wiry rootlets, the stumps
of which latter give it a rough and spiny appearance. It is nearly
cylindrical, often contorted, and of a yellowish-brown colour. The
fracture is short, exhibiting a loose structure, with large bright
yellow radiating woody bundles. The rhizome is intensely bitter,[19]
but not aromatic even when fresh.

It is found in the Indian bazaars in neat little open-work bags formed
of narrow strips of rattan, each containing about half an ounce. We
have once seen it in bulk in the London market.[20]

[10] See also Meyer, _Geschichte der Botanik_, ii. (1855) 419.

[11] _F. Z. Ermerins_, Anecdota medica Græca, e codicibus MSS.
expromsit. Lugd. Bat. 1840. Leonis Philosophi et Medici conspectus
medicinæ, lib. iii. cap. I. (Κεϕ. ά. Περὶὑϕθαλμῶν.....σαρκοκόλλς,
γλαμκίῳ, μαμηρᾀ καἰ καμϕορᾷ).

[12] Yule, _Cathay and the way thither_, (Hakluyt Society) i. (1866) p.
ccxvi.

[13] Davies, _Report on the trade of the countries on the N. W.
boundary of India_, Lahore, 1862.

[14] Otherwise written _Honglane_, _Chonlin_, _Chynlen_, _Chouline_,
_Souline_, &c.

[15] _Specimen Medicinæ Sinicæ_, Med. Simp. No. 27.

[16] _Mat. Med._ ii. (1778) 908.

[17] _Hist. des Drog._ ii. (1849) 526.

[18] _Trans. of Med. and Phys. Soc. of Calcutta_, iii. (1827) 432.

[19] Teeta is the Hindustani tāītā, from the Sanskrit tikta, “bitter.”
(Dr. Rice.)

[20] Two cases were offered for sale as _Olen_ or _Mishmee_ by Messrs.
Gray and Clark, drug-brokers, 22nd Nov. 1858.

=Microscopic Structure=—Cut transversely the rhizome exhibits an inner
cortical tissue, through which sclerenchymatous groups of cells are
scattered. The latter are most obvious on account of their bright
yellow colour. In the woody central column a somewhat concentric
arrangement is found, corresponding to two or three periods of annual
growth. The pith, not the medullary rays, begins to be obliterated
at an early period. The structure of the drug is, on the whole, very
irregular, on account of the branches and numerous rootlets arising
from it.

The medullary rays contain small starch granules, while the bark, as
well as the pith, are richer in albuminous or mucilaginous matters.

=Chemical Composition=—The colouring matter in which the rhizome of
_Coptis_ abounds, is quickly dissolved by water. If the yellow solution
obtained by macerating it in water is duly concentrated, nitric acid
will produce an abundant heavy precipitate of minute yellow crystals,
which if redissolved in a little boiling water will separate again in
stellate groups. Solution of iodine also precipitates a cold infusion
of the root.

These reactions as well as the bitterness of the drug are due to a
large proportion of _Berberine_, as proved by J. D. Perrins.[21] The
rhizome yielded not less than 8½ per cent., which is more than has been
met with in any other of the numerous plants containing that alkaloid.

As pure berberine is scarcely dissolved by water, it must be combined
in _Coptis_ with an acid forming a soluble salt. Further researches
are requisite to determine the nature of this acid. In some plants
berberine is accompanied by a second basic principle: whether in the
present instance such is the case, has not been ascertained.

=Uses=—The drug has been introduced into the _Pharmacopœia of India_ as
a pure, bitter tonic.

=Substitutes=—_Thalictrum foliolosum_ DC., a tall plant common at
Mussooree and throughout the temperate Himalaya at 5000-8000 feet, as
well as on the Khasia Hills, affords a yellow root which is exported
from Kumaon under the name _Momiri_. From the description in the
_Pharmacopœia of India_, it would appear to much resemble the _Mishmi
Tita_, and it is not impossible that some of the observations made
under the head _History_ (p. 3) may apply to _Thalictrum_ as well as to
_Coptis_.

In the United States the rhizome of _Coptis trifolia_ Salisb., a small
herb indigenous to the United States and Arctic America, and also found
in European and Asiatic Russia, is employed for the same purposes
as the Indian drug. It contains berberine and another crystalline
principle.[22]

[21] _Journ. of Chem. Soc._ xv. (1862) 339.

[22] Gross in _Am. Journ. of Pharm._ May 1873. 193.


SEMEN STAPHISAGRIÆ.

_Stavesacre_; F. _Staphisaigre_; G. _Stephanskörner_, _Läusesamen_.

=Botanical Origin=—_Delphinium Staphisagria_ L., a stout, erect,
biennial herb growing 3 to 4 feet high, with palmate, 5-to 9-lobed
leaves, which as well as the rest of the plant are softly pubescent.

It is a native of Italy, Greece, the Greek Islands and Asia Minor,
growing in waste and shady places; it is now also found throughout the
greater part of the Mediterranean regions and in the Canary Islands,
but whether in all instances truly indigenous is questionable. It is
cultivated to some extent in Puglia, very little now near Montpellier.

=History=—Stavesacre was well known to the ancients. It is the ἀγροτἔρη
σταϕὶς of Nicander,[23] the σταϕὶς ἀγρία of Dioscorides,[24] and
Alexander Trallianus,[25] the _Staphisagria_ or _Herba pedicularia_ of
Scribonius Largus,[26] the _Astaphis agria_ or _Staphis_ of Pliny.[27]
The last named author mentions the use of the powdered seeds for
destroying vermin on the head and other parts of the body.

The drug continued in use during the middle ages. Pietro
Crescenzio,[28] who lived in the 13th century, mentions the collection
of the seeds in Italy; and Simon Januensis,[29] physician to Pope
Nicolas IV. (A.D. 1288-1292), describes them—“_propter excellentem
operationem in caputpurgio_.”

[23] O. Schneider, _Nicandrea_, Lips. 1856. 271.

[24] _De Mat. Med._ lib. iv. c. 153.

[25] Puschmann’s edition (quoted in the Appendix) i. 450.

[26] _De Compositione Medicamentorum_, c. 165.

[27] Lib. xxiii. c. 13.

[28] _Libro della Agricultura_, Venet. (1511) lib. vi. c. 108.

[29] _Clavis Sanationis_, Venet. 1510.

=Description=—The fruit consists of three downy follicles, in each of
which about 12 seeds are closely packed in two rows. The seeds (which
alone are found in commerce) are about 3 lines in length and rather
less in width; they have the form of a very irregular 4-sided pyramid,
of which one side, much broader than the others, is distinctly vaulted.
They are sharp-angled, a little flattened, and very rough, the testa
being both wrinkled and deeply pitted. The latter is blackish-brown,
dull and earthy-looking, rather brittle, yet not hard. It encloses a
soft, whitish, oily albumen with a minute embryo at its sharper end.

The seeds have a bitter taste and occasion a tingling sensation when
chewed. Ten of them weigh about 6 grains.

=Microscopic Structure=—The epidermis of the seed consists of one layer
of large cells, either nearly cubical or longitudinally extended:
hence the wrinkles of the surface. The brown walls of these cells are
moderately thickened by secondary deposits, which may be made very
obvious by macerating thin sections in a solution of chromic acid, 1 p.
in 100 p. of water. By this treatment numerous crystals after a short
time make their appearance,—without doubt the chromate of one of the
alkaloids of staphisagria.

The outer layer of the testa is made up of thin-walled narrow cells,
which become larger near the edges of the seed and in the superficial
wrinkles. They contain a small number of minute starch granules and are
not altered on addition of a salt of iron. The interior layer exhibits
a single row of small, densely packed cells. The albumen is composed of
the usual tissue loaded with granules of albuminoid matter and drops of
fatty oil.

=Chemical Composition=—Brandes (1819) and Lassaigne and Feneulle (1819)
have shown this drug to contain a basic principle. Erdmann in 1864
assigned it the formula C₂₄H₃₅NO₂; he obtained it to the extent of
1 per mille in crystals, soluble in ether, alcohol, chloroform, or
benzol. The alkaloid has an extremely burning and acrid taste, and is
highly poisonous.

Couerbe[30] in 1833 pointed out the presence in stavesacre of a second
alkaloid separable from delphinine by ether in which it is insoluble.

The treatment of the shell of the seed with chromic acid, detailed
above, shows that this part of the drug is the principal seat of
the alkaloids; and the albumen indeed furnishes no crystals of any
chromate. In confirmation of this view we exhausted about 400 grammes
of the _entire seeds_ with warm spirit of wine acidulated with a little
acetic acid. The liquid was allowed to evaporate and the residue
mixed with warm water. The solution thus obtained, separated from the
resin, yielded on addition of chromic acid an abundant precipitate of
chromate. The same solution likewise furnished copious precipitates
when bichloride of platinum,[31] iodohydrargyrate of potassium, or
bichromate of potassium were added. By repeating the above treatment on
a larger scale we obtained crystals of delphinine of considerable size,
and also a second alkaloid not soluble in ether.

[30] _Ann. de Chimie et de Phys._ lii. (1833) 352.

[31] The platinic compound is in fine microscopic crystals.

In the laboratory of Dragendorff, Marquis in 1877 succeeded in
isolating the following alkaloids:—1. _Delphinine_, C₂₂H₃₅NO₆, yielding
crystals one inch in length, belonging to the rhombic System. They
are soluble in 11 parts of ether, 15 parts of chloroform, and 20
of absolute alcohol. 2. _Staphisagrine_, C₂₂H₃₃NO₅, is amorphous,
soluble in less than 1 part of ether, also in 200 parts of water at
150°. This alkaloid, although it would appear to be the anhydride of
the former, is in every respect widely different from delphinine. 3.
_Delphinoidine_ (formula not quite settled), amorphous, soluble in
three parts of ether, more abundantly occurring in the seed than the
two former alkaloids. In its physiological action delphinoidine agrees
with delphinine, not with staphisagrine. 4. _Delphisine_ (formula
doubtful) forms crystalline tufts, occurs in but small amount, is
sparingly soluble in alcohol, chloroform, or ether.—The total amount of
alkaloids afforded by stavesacre is about 1 per cent.

By exhausting the seeds with boiling ether, we get 27 per cent. of a
greenish, fatty oil, which continued fluid even at -5° C. It concreted
by means of hyponitric acid, and is therefore to be reckoned among the
non-drying oils; it contained a large part of the alkaloids.

The drug air-dry contains 8 per cent. of hygroscopic water. Dried at
100° C. and incinerated it left 8·7 per cent. of ash.

Nothing exact is known of the _Delphinic acid_ of Hofschläger (about
1820) said to be crystalline and volatile.

=Commerce=—The seeds are imported from Trieste and from the south of
France, especially from Nismes, near which city as well as in Italy
(Puglia) the plant is cultivated.

=Uses=—Stavesacre seeds are still employed as in old times for the
destruction of _pediculi_ in the human subject, for which purpose they
are reduced to powder which is dusted among the hair. Dr. Balmanno
Squire[32] having ascertained that _prurigo senilis_ is dependent on
the presence of _pediculus_, has recommended an ointment of which
theessential ingredients is the fatty oil of stavesacre seeds extracted
by ether. It is plain that such a preparation would contain delphinine.
Delphinine itself has been used externally in neuralgic affections.
Stavesacre seeds are largely consumed for destroying the pediculi that
infest cattle.

[32] _Pharm. Journ._ vi. (1865) 405, and vii. (1877) 1043.


RADIX ACONITI.

_Tuber Aconiti_; _Aconite Root_[33]; F. _Racine d’Aconit_; G.
_Eisenhutknollen_, _Sturmhutknollen_.

=Botanical Origin=—_Aconitum Napellus_ L.—This widely diffused and most
variable species grows chiefly in the mountainous districts of the
temperate parts of the northern hemisphere.

It is of frequent occurrence throughout the chain of the Alps up
to more than 6500 feet, the Pyrenees, the mountains of Germany and
Austria, and is also found in Denmark and Sweden. It has become
naturalized in a few spots in the west of England and in South Wales.
Eastward it grows throughout the whole of Siberia, extending to the
mountain ranges of the Pacific coast of North America. It occurs in
company with other species on the Himalaya at 10,000 to 16,000 feet
above the sea-level.

The plant is cultivated for medicinal use, and also for ornament.
The Abbé Armand David[34] saw in northern Sz-chuen (Setchuan) fields
planted with Aconite (A. Napellus?).

=History=—The Ἀκόνιτον of the Greeks and the _Aconitum_ of the Romans
are held to refer to the genus under notice, if not precisely to _A.
Napellus_. The ancients were well aware of the poisonous properties of
the aconites, though the plants were not more exactly distinguished
until the close of the middle ages. The Greek name is supposed to refer
to the same source as that of Conium. (See article on Fructus Conii.)

Aconite has been widely employed as an arrow-poison. It was used by
the ancient Chinese,[35] and is still in requisition among the less
civilized of the hill tribes of India. Something of the same kind was
in vogue among the aborigines of ancient Gaul.[36] Aconite was pointed
out in the thirteenth century, in “_The Physicians of Myddvai_,”[37] as
one of the plants which every physician is to grow.

Störck of Vienna introduced aconite into regular practice about the
year 1762[38]; the root and the herb occur in the German pharmaceutical
tariff of the seventeenth century.

[33] We use the word _root_ as most in accordance with the teaching of
English botanists.

[34] _Journal de mon troisième voyage en Chine_, i. (Paris 1875) 367.

[35] F. Porter Smith, _Mat. Med. and Nat. Hist. of China_, Shanghai,
1871. 2, 3.

[36] Pliny, lib. xxvii. c. 76, also xxv. 25.

[37] _The Physicians of Myddvai_; _Meddygon Myddfai_. Published for the
Welsh MSS. Society. Llandovery, 1861. 282, 457.

[38] _De Stramonio, Hyoscyamo et Aconito_, Vindob. 1762.

=Description=—The herbaceous annual stem of aconite starts from an
elongated conical tuberous root 2 to 4 inches long and sometimes as
much as an inch in thickness. This root tapers off in a long tail,
while numerous branching rootlets spring from its sides. If dug
up in the summer it will be found that a second and younger root
(occasionally a third) is attached to it near its summit by a very
short branch and is growing out of it on one side. This second root
has a bud at the top which is destined to produce the stem of the next
season. It attains its maximum development at the latter part of the
year, the parent root meanwhile becoming shrivelled and decayed. This
form of growth is therefore analogous to that of an orchis.

The dried root is more or less conical or tapering, enlarged and
knotty at the summit which is crowned with the base of the stem.
It is from 2 to 3 or 4 inches long and at the top from ½ to 1 inch
thick. The tuber-like portion of the root is more slender, much
shrivelled longitudinally, and beset with the prominent bases of
rootlets. The drug is of a dark brown; when dry it breaks with a
short fracture exhibiting a white and farinaceous, or brownish, or
grey inner substance sometimes hollow in the centre. A transverse
section of a sound root shows a pure white central portion (pith)
which is many-sided and has at each of its projecting angles a thin
fibro-vascular bundle.

In the fresh state the root of aconite has a sharp odour of radish
which disappears on drying. Its taste which is at first sweetish soon
becomes alarmingly acrid, accompanied with sensations of tingling and
numbness.

=Microscopic Structure=—The tuberous root as seen in a transverse
section, consists of a central part enclosed by a delicate cambial
zone. The outer part of this central portion exhibits a thin brownish
layer made up of a single row of cells (_Kernscheide_ of the Germans).
This is more distinctly obvious in the rootlets, which also show
numerous, scattered, thick-walled cells of a yellow colour.

The fibro-vascular bundles of aconite root are devoid of true ligneous
cells; its tissue is for the largest part built up of uniform
parenchymatous cells loaded with starch granules.

=Chemical Composition=—Aconite contains chemical principles which are
of great interest on account of their virulent effects on the animal
economy.

The first to be mentioned is _Aconitine_, a highly active
crystallizable alkaloid, furnishing readily crystallizable salts. It
is accompanied by another active alkaloid, _Pseudaconitine_, which
is crystallizable, but yields mostly amorphous salts. According to
the admirable researches of Wright and Luff,[39] aconitine may be
decomposed according to the following equation:—

    C₃₃H₄₃NO₁₂. OH₂ =    C₇H₆O₂.   C₂₆H₃₉NO₁₁,
    Aconitine.        Benzoic acid.    Aconine.

and pseudaconitine breaks up in accordance with the equation:

     C₃₆H₄₉NO₁₁.   OH₂ =    C₉H₁₀O₄.     C₂₇H₄₁NO₈
    Pseudaconitine.        Dimethyl-      Pseudaconine.
                      protocatechnic acid.

[39] _Pharm. Journ._ 1875 to 1878, also _Yearbook of Pharmacy_, the
results being summarized in the _Yearbook_ for 1877, 466.—Comparative
qualitative reactions of Aconitine, Aconine, Pseudaconitine, and
Pseudaconine, see _Yearbook_ (1877) 459.

The decomposition of aconitine, as well as of pseudaconitine, may
be performed by means of mineral acids, alkaline solutions, or also
by heating the bases with water in sealed tubes. The two alkaloids,
_Aconine_ and _Pseudaconine_, appear to be present already in the
roots of Aconitum; they, moreover, contain two other alkaloids of less
physiological potency. One of them, _Picraconitine_, C₃₁H₄₅NO₁₀, is
merely bitter, producing no lip-tingling; it gives well crystallized
salts, although it is itself amorphous. Commercial aconitine is a
mixture of the above alkaloids. The total yield of basic substances
afforded by aconite root is not more than about 0·07 per cent.

The other constituents of aconite root are but imperfectly known. In
the preparation of the alkaloids, a dark green mixture of resin and
fat is obtained; it is much more abundant in European than in Nepal
aconite (Groves). The root contains _Mannite_, as proved by T. and H.
Smith (1850), together with cane-sugar, and another sugar which reduces
cupric oxide even in the cold. Tannin is absent, or is limited to the
corky coat. The absence of a volatile alkaloid in the root was proved
by Groves in 1866.

=Uses=—Prescribed in the form of tincture as an anodyne liniment;
occasionally given internally in rheumatism.

=Adulteration and Substitution=—Aconite root, though offered in
abundance in the market, is by no means always obtained of good
quality. Collected in the mountainous parts of Europe by peasants
occupied in the pasturing of sheep and cattle, it is often dug
up without due regard to the proper season or even to the proper
species,—a carelessness not surprising when regard is had to the
miserable price which the drug realizes in the market.[40]

One of the species not unfrequent in the Alps, of which the roots
are doubtless sometimes collected, is _A. Störckeanum_ Reichenb. In
this plant the tuberous roots are developed to the number of three or
four, and have an anatomical structure slightly different from that
of _A. Napellus_.[41] _A. variegatum_ L., _A. Cammarum Jacq._, and
_A. paniculatum_ Lam. are blue-flowered species having tuberous roots
resembling those of _A. Napellus_, but according to Schroff somewhat
less active.

The yellow-flowered _A. Anthora_ L. and _A. Lycoctonum_ L. produce
roots which cannot be confounded with those of _A. Napellus_ L.

The root of _A. japonicum_ Thunb. has been noticed in Europe by
Christison as early as 1859[42]; it is now imported occasionally from
the East. It forms grey or almost blackish tubers from ⁶/₁₀ of an
inch to upwards of 1 inch in length, and from ²/₁₀ to ⁴/₁₀ of an inch
in diameter, oblong or ovoid, either tapering or rounded at their
extremities. They are of plump, scarcely shrivelled appearance.[43]

_Japanese aconite_ afforded to Wright and Luff a crystallized active
alkaloid different from both aconitine and pseudaconitine.

Holmes[44] states that the _aromatic_ roots of _Imperatoria Ostruthium_
L. have been found mixed with aconite.

[40] Thus the continental druggists are able to offer it in quantity as
low as 4_d._ to 5_d._ per lb., and a pound, we find, contains fully 150
roots!

[41] See figure in Berg’s _Atlas zur pharm. Waarenkunde_ (1865) fig. 24.

[42] Hanbury, _Science Papers_ (1876) 258, with figure. See also
_Pharm. Journ._ ix. (1879) 615, where the drug is derived from Aconitum
Fischeri.

[43] Their microscopic structure is figured in the paper of Dr. Dunin
(quoted farther on, in our article on Aconitum heterophyllum at p. 14)
217-225.

[44] _Pharm. Journ._ vii. (1877) 749.


FOLIA ACONITI.

_Herba Aconita_; _Aconite Leaves_; F. _Feuilles d’Aconit_; G.,
_Eisenhutkraut_, _Sturmhutkraut_.

=Botanical Origin=—_Aconitum Napellus_ L., see preceding article.

=History=—Aconite herb was introduced into medicine in 1762 by Störck
of Vienna; and was admitted into the London Pharmacopœia in 1788.

=Description=—The plant produces a stiff, upright, herbaceous, simple
stem, 3 to 4 feet high, clothed as to its upper half with spreading,
dark green leaves, which are paler on their under side. The leaves
are from 3 to 5 or more inches in length, nearly half consisting of
the channelled petiole. The blade, which has a roundish outline, is
divided down to the petiole into three principal segments, of which the
lateral are subdivided into two or even three, the lowest being smaller
and less regular than the others. The segments, which are trifid, are
finally cut into 2 to 5 strap-shaped pointed lobes. The leaves are
usually glabrous, and are deeply impressed on their upper side by
veins which run with but few branchings to the tip of every lobe. The
uppermost leaves are more simple than the lower, and gradually pass
into the bracts of the beautiful raceme of dull-blue helmet-shaped
flowers which crowns the stem.

The leaves have when bruised a herby smell; their taste is at first
mawkish but afterwards persistently burning.

=Chemical Composition=—The leaves contain aconitine in small proportion
and also aconitic acid,—the latter in combination with lime.

_Aconitic Acid_, C₁₆H₆O₆, discovered by Peschier in 1820 in somewhat
considerable quantity in the leaves of aconite, occurs also in those
of larkspur, and is identical with the _Equisetic Acid_ of Braconnot
and the _Citridic Acid_ of Baup.[45] It has been stated to be present
likewise in Adonis vernalis L. (Linderos, 1876,—10 per cent. of dried
leaves!) and in the sugar cane (Behr, 1877).

Schoonbroodt[46] (1867) on treating the extract with a mixture of
alcohol and ether, obtained acicular crystals, which he thought were
the so-called _Aconella_ of Smith. He further found that the distillate
of the plant was devoid of odour, but was acid, and had a burning
taste. By saturation with an alkali he obtained from it a crystalline
substance, soluble in water, and having a very acrid taste. Experiments
made about the same time by Groves,[47] a careful observer, led to
opposite results. He distilled on different occasions both fresh herb
and fresh roots, and obtained a _neutral_ distillate, smelling and
tasting strongly of the plant, but entirely devoid of acridity. Hence
he concluded that _A. Napellus_ contains no volatile acrid principle.

In an extract of aconite that has been long kept, the microscope
reveals crystals of aconitate of calcium, as well as of sal-ammoniac.

The leaves contain a small proportion of sugar, and a tannin striking
green with iron. When dried they yield on incineration 16·6 per cent.
of ash.

=Uses=—In Britain the leaves and small shoots are only used in the
fresh state, the flowering herb being purchased by the druggist in
order to prepare an inspissated juice,—_Extractum Aconiti_. This
preparation, which is considered rather uncertain in its action, is
occasionally prescribed for the relief of rheumatism, inflammatory and
febrile affections, neuralgia, and heart diseases.

[45] Gmelin, _Chemistry_, xi. (1857) 402.

[46] Wittstein’s _Vierteljahresschrift_, xviii. (1869) 82, also
_Jahresbericht_ of Wiggers and Husemann (1869) 12.

[47] _Pharm. Journ._ viii. (1867) 118.


RADIX ACONITI INDICA.

_Bish_, _Bis_ or _Bikh_, _Indian Aconite Root_, _Nepal Aconite_.

=Botanical Origin=—The poisonous root known in India as _Bish_, _Bis_,
or _Bikh_[48] is chiefly derived from _Aconitum ferox_ Wallich, a plant
growing 3 to 6 feet high and bearing large, dull-blue flowers, native
of the temperate and sub-alpine regions of the Himalaya at an elevation
of 10,000 to 14,000 feet in Garhwal, Kumaon, Nepal and Sikkim.[49] In
the greater part of these districts, other closely allied and equally
poisonous species occur, viz. _A. uncinatum_ L., _A. luridum_, H.
f. et Th., _A. palmatum_ Don, and also abundantly _A. Napellus_ L.,
which last, as already mentioned, grows throughout Europe as well as
in Northern Asia and America. The roots of these plants are collected
indiscriminately according to Hooker and Thomson[50] under the name of
_Bish_ or _Bikh_.

=History=—The Sanskrit name of this potent drug, _Visha_, signifies
simply _poison_, and _Ativisha_, a name which it also bears, is
equivalent to “_summum venenum_.” _Bish_ is mentioned by the Persian
physician Alhervi[51] in the 10th century as well as by Avicenna[52]
and many other Arabian writers on medicine,—one of whom, Isa Ben Ali,
calls it the most rapid of deadly poisons, and describes the symptoms
it produces with tolerable correctness.[53]

Upon the extinction of the Arabian school of medicine this virulent
drug seems to have fallen into oblivion. It is just named by Acosta
(1578) as one of the ingredients of a pill which the Brahmin physicians
give in fever and dysentery.[54] There is also a very strange reference
to it as “_Bisch_” in the Persian Pharmacopœia of Father Ange, where
it is stated[55] that the root, though most poisonous when fresh, is
perfectly innocuous when dried, and that it is imported into Persia
from India, and _mixed with food and condiments as a restorative_! Ange
was aware that it was the root of an aconite.

[48] The Arabic name _Bish_ or Persian _Bis_ is stated by Moodeen
Sheriff in his _Supplement to the Pharmacopœia of India_ (p. 265) to be
a more correct designation than _Bikh_, which seems to be a corruption
of doubtful origin. We find that the Arabian writer Ibn Baytar gives
the word as _Bish_ (not _Bikh_).

[49] Figured in Bentley and Trimen, _Med. Plants_ (1877) pt. 27.

[50] _Flor. Ind._ i. (1855) 54, 57; and Introd. Essay, 3.

[51] Abu Mansur Mowafik ben Ali Alherui, _Liber Fundamentorum
Pharmacologiæ_, i. (Vindob. 1830) 47. Seligmann’s edition.

[52] Valgrisi edition, 1564, lib. ii. tract. 2. it. N. (p. 347).

[53] Ibn Baytar, Sontheimers transl. i. (1840) 199.

[54] Clusius, _Exotica_, 289.

[55] _Pharm. Persica_, 1681, p. 17, 319, 358. The word _bisch_ is
correctly given in Arabic characters, so that of its identity there can
be no dispute. (_Pharm. persica_, see appendix: Angelus.)

The poisonous properties of _Bish_ were particularly noticed by
Hamilton (late Buchanan)[56] who passed several months in Nepal in
1802-3: but nothing was known of the plant until it was gathered by
Wallich and a description of it as _A. ferox_ communicated by Seringe
to the Société de physique de Genève in 1822.[57] Wallich himself
afterwards gave a lengthened account of it in his _Plantæ Asiaticæ
Rariores_ (1830).[58]

=Description=—Balfour, who also figures _A. ferox_,[59] describes
the plant from a specimen that flowered in the Botanical Garden of
Edinburgh as—“having 2—3 fasciculated, fusiform, attenuated tubers,
some of the recent ones being nearly 5 inches long, and 1½ inches in
circumference, dark brown externally, white within, sending off sparse,
longish branching fibres.”

Aconite root has of late been imported into London from India in
considerable quantity, and been offered by the wholesale druggists
as _Nepal Aconite_.[60] It is of very uniform appearance, and seems
derived from a single species, which we suppose to be _A. ferox_. The
drug consists of simple tuberous roots of an elongated conical form, 3
to 4 inches long, and ½ to 1¾ inches in greatest diameter. Very often
the roots have been broken in being dug up and are wanting in the
lower extremity: some are nearly as broad at one end as at the other.
They are mostly flattened and not quite cylindrical, often arched,
much shrivelled chiefly in a longitudinal direction, and marked rather
sparsely with the scars of rootlets. The aerial stem has been closely
cut away, and is represented only by a few short scaly rudiments.[61]

The roots are of a blackish brown, the prominent portions being
often whitened by friction. In their normal state they are white and
farinaceous within, but as they are dried by fire-heat and often even
scorched, their interior is generally horny, translucent, and extremely
compact and hard. The largest root we have met with weighed 555 grains.

In the Indian Bazaars, _Bish_ is found in another form, the tuberous
roots having been steeped in cow’s urine to preserve them from
insects.[62] These roots which in our specimen[63] are mostly plump and
cylindrical, are flexible and moist when fresh, but become hard and
brittle by keeping. They are externally of very dark colour, black and
horny within, with an offensive odour resembling that of hyraceum or
castor. Immersed in water, though only for a few moments, they afford a
deep brown solution. Such a drug is wholly unfit for use in medicine,
though not unsuitable, perhaps, for the poisoning of wild beasts, a
purpose to which it is often applied in India.[64]

[56] _Account of the Kingdom of Nepal_, Edin. 1819, 98.

[57] _Musée Helvétique d’Hist. Nat._ Berne, i. (1823) 160.

[58] Yet strange to say confused the plant with _A. Napellus_, an
Indian form of which he figured as _A. ferox_!

[59] _Edinb. New Phil Journ._ xlvii. (1849) 366, pl. 5.

[60] The first importation was in 1869, when ten bags containing 1,000
lbs., said to be part of a much larger quantity actually in London,
were offered for sale by a drug-broker.

[61] There is a rude woodcut of the root in _Pharm. Journ._ i. (1871)
434.

[62] A specimen of ordinary _Bish_ in my possession for two or three
years became much infested by a minute and active insect of the genus
_Psocus_.—D. H.

[63] Obligingly sent to me in 1867 by Messrs. Rogers & Co. of Bombay,
who say it is the only kind there procurable.—D. H.

[64] According to Moodeen Sheriff (_Supplement to Pharm. of India_, pp.
25-32, 265) there are several kinds of aconite root found in the Indian
bazaars, some of them highly poisonous, others innocuous. The first or
poisonous aconites he groups under the head _Aconitum ferox_, while the
second, of which there are three varieties mostly known by the Arabic
name _Jadvár_ (Persian _Zadvár_), he refers to undetermined species of
_Aconitum_.

The surest and safest names in most parts of India for the poisonous
aconite roots are _Bish_ (Arabic); _Bis_ (Persian); _Singyā-bis_,
_Mīthā-zahar_, _Bachhnāg_ (Hindustani); _Vasha-nāvi_ (Tamil);
_Vasa-nābhi_ (Malyalim).

=Microscopic Structure=—Most of the roots fail to display any
characteristic structure by reason of the heat to which they have
been subjected. A living root sent to us from the Botanical Garden of
Edinburgh exhibited the thin brownish layer which encloses the central
part in _A. Napellus_, replaced by a zone of stone-cells,—a feature
discernible in the imported root.

=Chemical Composition=—According to Wright and Luff (see previous
article) the roots of _Aconitum ferox_ contain comparatively large
quantities of pseudaconitine with a little aconitine and an alkaloid,
apparently non-crystalline, which would appear not to agree with the
analogous body from _A. Napellus_.

=Uses=—The drug has been imported and used as a source of aconitine. It
is commonly believed to be much more potent than the aconite root of
Europe.


RADIX ACONITI HETEROPHYLLI.

_Atís or Atees._

=Botanical Origin=—_Aconitum heterophyllum_ Wallich, a plant of 1 to 3
feet high with a raceme of large flowers of a dull yellow veined with
purple, or altogether blue, and reniform or cordate, obscurely 5-lobed,
radical leaves.[65] It grows at elevations of 8000 to 13,000 feet in
the temperate regions of the Western Himalaya, as in Simla, Kumaon and
Kashmír.

=History=—We have not met with any ancient account of this drug, which
however is stated by O’Shaughnessy[66] to have been long celebrated in
Indian medicine as a tonic and aphrodisiac. It has recently attracted
some attention on account of its powers as an antiperiodic in fevers,
and has been extensively prescribed by European physicians in India.

=Description=—The tuberous roots of _A. heterophyllum_ are ovoid,
oblong, and downward-tapering or obconical; they vary in length from
½ to 1½ inches and in diameter from ³/₁₀ to ⁶/₁₀ of an inch, and
weigh from 5 to 45 grains. They are of a light ash colour, wrinkled
and marked with scars of rootlets, and have scaly rudiments of leaves
at the summit. Internally they are pure white and farinaceous. A
transverse section shows a homogeneous tissue with 4 to 7 yellowish
vascular bundles. In a longitudinal section these bundles are seen to
traverse the root from the scar of the stem to the opposite pointed
end, here and there giving off a rootlet. The taste of the root is
simply bitter with no acridity.

[65] Beautifully figured in Royle’s _Illustrations of the Botany of the
Himalayan mountains_, &c., 1839, tab. 13; also in Bentley and Trimen’s
_Medicinal Plants_, Part 27 (1877).

[66] _Bengal Dispensatory_, 1842. 167.

=Microscopic Structure=—The tissue is formed of large angular
thin-walled cells loaded with starch which is either in the form of
isolated or compound granules. The vascular bundles contain numerous
spiroid vessels which seen in transverse section appear arranged so as
to form about four rays. The outer coat of the root is made up of about
six rows of compressed, tabular cells with faintly brownish walls.

=Chemical Composition=—The root contains _Atisine_, an amorphous
alkaloid of intensely bitter taste discovered by Broughton,[67] who
assigns to it the formula C₄₆H₇₄N₂O₅, obtained from concurrent analysis
of a platinum salt. The alkaloid is readily soluble in bisulphide of
carbon or in benzol, also to some extent in water. It is of decidedly
alkaline reaction, devoid of any acridity. Atisine has also been
prepared (1877) by Dunin[68] from the root in the laboratory of one of
us. We have before us its hydroiodate, forming colourless crystallized
scales, which we find to be very sparingly soluble in cold alcohol or
water. At boiling temperature the hydroiodate of atisine is readily
dissolved; the aqueous solution on cooling yields beautiful crystals.
They agree, according to Dunin, with the formula C₄₆H₇₄N₂O₄. HI + OH₂;
this chemist has also shown atisine not to be poisonous. The absence in
the drug of aconitine is proved by medical experience,[69] and fully
confirmed by the absence of any acridity in the root.

=Uses=—The drug is stated to have proved a valuable remedy in
intermittent and other paroxysmal fevers. In ordinary intermittents it
may be given in powder in 20-grain doses. As a simple tonic the dose is
5 to 10 grains thrice a day.

=Substitutes=—The native name _Atís_ applied in India to several other
drugs, one of which is an inert tasteless root commonly referred to
_Asparagus sarmentosus_ L. In Kunawar the tubers of _Aconitum Napellus_
L. are dug up and eaten as a tonic, the name _atís_ being applied to
them as well as to those of _A. heterophyllum_.[70]

[67] _Pharm. Journ._ vi (1875) 189; also Blue Book, East India
Chinchona Cultivation, 1877. 133.

[68] Dr. M. Dunin von Wasowicz has devoted to the drug under notice
an elaborate paper in the _Archiv der Pharmacie_, 214 (1879) 193-216,
including its structure, which he illustrates by engravings.

[69] _Pharm. of India_, 1868. 4. 434.

[70] Hooker and Thomson (on the authority of Munro) _Flor. Ind._ 1855.
58.


RADIX CIMICIFUGÆ.

_Radix Actæa racemosæ_; _Black Snake-root_, _Black Cohosh_, _Bugbane_.

=Botanical Origin=—_Cimicifuga racemosa_ Elliott (_Actæa racemosa_ L.),
a perennial herb 3 to 8 feet high, abundant in rich woods in Canada
and the United States, extending southward to Florida.[71] It much
resembles _Actæa spicata_ L., a plant widely spread over the northern
parts of Europe, Asia, and America, occurring also in Britain; but
it differs in having an elongated raceme of 3 to 8 inches in length
and dry dehiscent capsules. _A. spicata_ has a short raceme and juicy
berries, usually red.

[71] For figure, see Bentley and Trimen, _Med. Plants_, Part 23 (1877).

=History=—The plant was first made known by Plukenet in 1696 as
_Christophoriana Canadensis racemosa_. It was recommended in 1743 by
Colden[72] and named in 1749 by Linnæus in his _Materia Medica_ as
_Actæa racemis longissimis_. In 1823 it was introduced into medical
practice in America by Garden; it began to be used in England about the
year 1860.[73]

=Description=—The drug consists of a very short, knotty, branching
rhizome, ½ an inch or more thick, having, in one direction, the remains
of several stout aerial stems, and in the other, numerous brittle,
wiry roots, ¹/₂₀ to ⅒ of an inch in diameter, emitting rootlets still
smaller. The rhizome is of somewhat flattened cylindrical form,
distinctly marked at intervals with the scars of fallen leaves. A
transverse section exhibits in the centre a horny whitish pith, round
which are a number of rather coarse, irregular woody rays, and outside
them a hard, thickish bark. The larger roots when broken display a
thick cortical layer, the space within which contains converging wedges
of open woody tissue 3 to 5 in number forming a star or cross,—a
beautiful and characteristic structure easily observed with a lens. The
drug is of a dark blackish brown; it has a bitter, rather acrid and
astringent taste, and a heavy narcotic smell.

=Microscopic Structure=—The most striking character is afforded by the
rootlets, which on a transverse section display a central woody column,
traversed usually by 4 wide medullary rays and often enclosing a pith.
The woody column is surrounded by a parenchymatous layer separated
from the cortical portion by one row of densely packed small cells
constituting a boundary analogous to the nucleus-sheath (_Kernscheide_)
met with in many roots of monocotyledons, as for instance in
sarsaparilla. The parenchyme of cimicifuga root contains small starch
granules. The structure of the drug is, on the whole, the same as that
of the closely allied European _Actæa spicata_ L.

=Chemical Composition=—Tilghmann[74] in 1834 analysed the drug,
obtaining from it gum, sugar, resin, starch and tannic acid, but no
peculiar principal.

Conard[75] extracted from it a neutral crystalline substance of
intensely acrid taste, soluble in dilute alcohol, chloroform, or ether,
but not in benzol, oil of turpentine, or bisulphide of carbon. The
composition of this body has not been ascertained. The same chemist
showed the drug not to afford a volatile principle, even in its fresh
state.

The American practitioners called _Eclectics_ prepare with _Black
Snake-root_ in the same manner as they prepare podophyllin, an impure
resin which they term _Cimicifugin_ or _Macrotin_. The drug yields,
according to Parrish, 3¾ per cent. of this substance, which is sold in
the form of scales or as a dark brown powder.

=Uses=—Cimicifuga usually prescribed in the form of tincture (called
_Tinctura Actæa racemosæ_) has been employed chiefly in rheumatic
affections. It is also used in dropsy, the early stages of phthisis,
and in chronic bronchial disease. A strong tincture has been lately
recommended in America as an external application for reducing
inflammation.[76]

[72] _Acta Soc. Reg. Scient. Upsal._ 1743. 131.

[73] Bentley, _Pharm. Journ._ ii. (1861) 460.

[74] Quoted by Bentley.

[75] _Am. Journ. of Pharm._ xliii. (1871) 151; _Pharm. Journ._ April
29, 1871. 866.

[76] _Yearbook of Pharmacy_, 1872. 385.




MAGNOLIACEÆ.


CORTEX WINTERANUS.

_Cortex Winteri_, _Cortex Magellanicus_; _Winter’s Bark_, _Winter’s
Cinnamon_; F. _Ecorce de Winter_; G. _Wintersrinde_, _Magellanischer
Zimmt_.

=Botanical Origin=—_Drimys[77] Winteri_ Forster, a tree distributed
throughout the American continent from Mexico to Cape Horn. It
presents considerable variation in form and size of leaf and flower in
the different countries in which it occurs, on which account it has
received from botanists several distinct specific names. Hooker[78]
has reduced these species to a single type, a course in which he
has been followed by Eichler in his monograph of the small order
_Winteraceæ_[79].—In April, 1877, the tree was blossoming in the open
air in the botanic garden at Dublin.

[77] From δριμὺς, _acrid_, _biting_.

[78] _Flora Antarctica_, ii. (1847) 229.

[79] Martius, _Flor. Bras._ fasc. 38 (1864) 134. Eichler however admits
five principal varieties, viz. α. _Magellanica_; β. _Chilensis_; γ.
_Granatensis_; δ. _revoluta_; ε. _angustifolia_.

=History=—In 1577 Captain Drake, afterwards better known as Sir Francis
Drake, having obtained from Queen Elizabeth a commission to conduct a
squadron to the South Seas, set sail from Plymouth with five ships; and
having abandoned two of his smaller vessels, passed into the Pacific
Ocean by the Straits of Magellan in the autumn of the following year.
But on the 7th September, 1578, there arose a dreadful storm, which
dispersed the little fleet. Drake’s ship, the _Pelican_, was driven
southward, the _Elizabeth_, under the command of Captain Winter,
repassed the Straits and returned to England, while the third vessel,
the _Marigold_, was heard of no more.

Winter remained three weeks in the Straits of Magellan to recover the
health of his crew, during which period, according to Clusius (the fact
is not mentioned in Hakluyt’s account of the voyage), he collected
a certain aromatic bark, of which, having removed the acridity by
steeping it in honey, he made use as a spice and medicine for scurvy
during his voyage to England, where he arrived in 1579.

A specimen of this bark having been presented to Clusius, he gave it
the name of _Cortex Winteranus_, and figured and described it in his
pamphlet: “Aliquot notæ in Garciæ aromatum historiam,” Antverpiæ,
1582, p. 30, and also in the _Libri Exoticorum_, published in 1605.
He afterwards received a specimen with wood attached, which had been
collected by the Dutch navigator Sebald de Weerdt.

Van Noort, another well-known Dutch navigator, who visited the Straits
of Magellan in 1600, mentions cutting wood at Port Famine to make a
boat, and that the bark of the trees was hot and biting like pepper. It
is stated by Murray that he also brought the bark to Europe.

But although the straits of Magellan were several times visited about
this period, it is certain that no regular communication between
that remote region and Europe existed either then or subsequently;
and we may reasonably conclude that Winter’s Bark became a drug of
great rarity, and known to but few persons. It thus happened that,
notwithstanding most obvious differences, the Canella alba of the West
Indies, and another bark of which we shall speak further on, having
been found to possess the pungency of Winter’s Bark, were (owing to
the scarcity of the latter) substituted for it, until at length the
peculiar characters of the original drug came to be entirely forgotten.

The tree was figured by Sloane in 1693, from a specimen (still extant
in the British Museum) brought from Magellan’s Straits by Handisyd, a
ship’s surgeon, who had experienced its utility in treating scurvy.

Feuillée,[80] a French botanist, found the Winter’s Bark-tree in Chili
(1709-11), and figured it as _Boigue cinnamomifera_. It was, however,
Forster,[81] the botanist of Cook’s second expedition round the
world, who first described the tree accurately, and named it _Drimys
Winteri_. He met with it in 1773 in Magellan’s Straits, and on the
eastern coasts of Tierra del Fuego, where it grows abundantly, forming
an evergreen tree of 40 feet, while on the western shores it is but
a shrub of 10 feet high. Specimens have been collected in these and
adjacent localities by many subsequent botanists, among others by Dr.
J. D. Hooker, who states that about Cape Horn the tree occurs from the
sea-level to an elevation of 1000 feet.

Although the bark of _Drimys_ was never imported as an article of trade
from Magellan’s Straits, it has in recent times been occasionally
brought into the market from other parts of South America, where it is
in very general use. Yet so little are drug dealers acquainted with it,
that its true name and origin have seldom been recognized.[82]

[80] _Journ. des observations physiques_, &c. iv. 1714. 10, pl. 6.

[81] _Characteres Generum Plantarum_, 1775. 42.

[82] We have seen it offered in a drug sale at one time as “_Pepper
Bark_,” at another as “_Cinchona_.” Even Mutis thought it a Cinchona,
and called it “_Kinkina urens_”!

=Description=—We have examined specimens of true Winter’s Bark from the
Straits of Magellan, Chili, Peru, New Granada, and Mexico, and find in
each the same general characters. The bark is in quills or channelled
pieces, often crooked, twisted or bent backwards, generally only a few
inches in length. It is most extremely thick (⅒ to ³/₁₀ of an inch) and
appears to have shrunk very much in drying, bark a quarter of an inch
thick having sometimes rolled itself into a tube only three times as
much in external diameter. Young pieces have an ashy-grey suberous coat
beset with lichens. In older bark, the outer coat is sometimes whitish
and silvery, but more often of a dark rusty brown, which is the colour
of the internal substance, as well as of the surface next the wood. The
inner side of the bark is strongly characterized by very rough striæ,
or, as seen under a lens, by small short and sharp longitudinal ridges,
with occasional fissures indicative of great contraction of the inner
layer in drying. In a piece broken or cut transversely, it is easy to
perceive that the ridges in question are the ends of rays of white
liber which diverge towards the circumference in radiate order, a dark
rusty parenchyme intervening between them. No such feature is ever
observable in either _Canella_ or _Cinnamodendron_.

Winter’s Bark has a short, almost earthy fracture, an intolerably
pungent burning taste, and an odour which can only be described as
terebinthinous. When fresh its smell may be more agreeable. The
descriptions of Clusius, as alluded to above, are perfectly agreeing
and even his figures as nearly as might be expected.

=Microscopic Structure=—In full-grown specimens the most striking fact
is the predominance of sclerenchymatous cells. The tissue moreover
contains numerous large oil-ducts, chiefly in the inner portion of the
large medullary rays. A fibrous structure of the inner part of the bark
is observable only in the youngest specimens.[83] Very small starch
granules are met with in the drug, yet less numerous than in canella.
The tissue of the former assumes a blackish blue colour on addition of
perchloride of iron.

The wood of _Drimys_ consists of dotted prosenchyme, traversed by
medullary rays, the cells of which are punctuated and considerably
larger than in _Coniferæ_.

=Chemical Composition=—No satisfactory chemical examination has been
made of true Winter’s Bark. Its chief constituents, as already pointed
out, are tannic matters and essential oil, probably also a resin. In a
cold aqueous infusion, a considerable amount of mucilage is indicated
by neutral acetate of lead. On addition of potash it yields a dark
somewhat violet liquid. Canella alba is but little altered by the same
treatment. By reason of its astringency the bark is used in Chili for
tanning.[84]

=Uses=—Winter’s Bark is a stimulating tonic and antiscorbutic, now
almost obsolete in Europe. It is much used in Brazil and other parts of
South America as a remedy in diarrhœa and gastric debility.

=Substitute=—_False Winter’s Bark_—We have shown that the bark of
_Drimys_ or True Winter’s Bark has been confounded with the pungent
bark of _Canella alba_ L., and with an allied bark, also the produce of
Jamaica. The latter is that of _Cinnamodendron corticosum_ Miers,[85] a
tree growing in the higher mountain woods of St. Thomas-in-the-Vale and
St. John, but not observed in any other of the West Indian islands than
Jamaica. It was probably vaguely known to Sloane when he described the
“_Wild Cinamon tree, commonly, but falsely, called_ Cortex Winteranus,”
which, he says, has leaves resembling those of _Lauro-cerasus_; though
the tree he figures is certainly _Canella alba_.[86] Long[87] in
1774, speaks of _Wild Cinamon_, _Canella alba_, or _Bastard Cortex
Winteranus_, saying that it is used by most apothecaries instead of the
true _Cortex Winteranus_.

[83] The structure of Winter’s Bark is beautifully figured by Eichler,
_loc. cit._ tab. 32.

[84] Perez-Rosales, _Essai sur le Chili_, 1857. 113.

[85] _Annals of Nat. Hist._, May 1858; also Miers’ _Contributions to
Botany_, i. 121, pl. 24, _Bot. Magaz._, Sept. 1874, vol. xxx. pl. 6121,
and Bentley and Trimens’ _Medicinal Plants_, part 10.

[86] _Phil. Trans._ xvii for 1693. 465.

[87] _Hist. of Jamaica._ London, iii. (1774) 705—also i. 495.

It is probable that both writers really had in view _Cinnamodendron_,
the bark of which has been known and used as _Winter’s Bark_, both in
England and on the continent from an early period up to the present
time.[88] It is the bark figured as _Cortex Winteranus_ by Goebel and
Kunze[89] and described by Mérat and De Lens,[90] Pereira, and other
writers of repute. Guibourt indeed pointed out in 1850 its great
dissimilarity to the bark of _Drimys_ and questioned if it could be
derived from that genus.

It is a strange fact that the tree should have been confounded with
_Canella alba_ L., differing from it as it does in the most obvious
manner, not only in form of leaf, but in having the flowers _axillary_,
whereas those of _C. alba_ are _terminal_. Although _Cinnamodendron
corticosum_ is a tree sometimes as much as 90 feet high[91] and must
have been well known in Jamaica for more than a century, yet it had
no botanical name until 1858 when it was described by Miers[92] and
referred to the small genus _Cinnamodendron_ which is closely allied to
_Canella_.

The bark of _Cinnamodendron_ has the general structure of Canella alba.
There is the same thin corky outer coat (which is _not_ removed) dotted
with round scars, the same form of quills and fracture. But the tint is
different, being more or less of a ferruginous brown. The inner surface
which is a little more fibrous than in canella, varies in colour, being
yellowish, brown, or of a deep chocolate. The bark is violently pungent
but not bitter, and has a very agreeable cinnamon-like odour.

In _microscopic structure_ it approaches very close to canella; yet
the thick-walled cells of the latter exist to a much larger extent and
are here seen to belong to the suberous tissue. The medullary rays are
loaded with oxalate of calcium.

Cinnamodendron bark has not been analysed. Its decoction is blackened
by a persalt of iron whereby it may be distinguished from Canella alba;
and is coloured intense purplish brown by iodine, which is not the case
with a decoction of true Winter’s Bark.

[88] It is so labelled in the Museum of the Pharmaceutical Society,
28th April, 1873.

[89] _Pharm. Waarenkunde_, 1827-29. i. Taf. 3. fig. 7.

[90] As shown by De Lens’ own specimen kindly given to us by Dr. J.
Léon Soubeiran. There are specimens of the same bark about a century
old marked _Cortex Winteranus verus_ in Dr. Burges’s cabinet of drugs
belonging to the Royal College of Physicians.

[91] Griesbach calls it a low shrubby tree, 10-15 feet high. Mr. N.
Wilson, late of the Bath Botanic Garden, Jamaica, has informed me it
grows to be 40-45 in height, but that he has seen a specimen 90 feet
high. (Letter 22 May 1862.)—D. H.

[92] _Loc. cit._


FRUCTUS ANISI STELLATI.

_Semen Badiana_[93]; _Star-Anise_; F. _Badiane_, _Anis étoilé_; G.
_Sternanis_.

=Botanical Origin=—_Illicium anisatum_ Loureiro (_I. religiosum_
Sieb.). A small tree, 20 to 25 feet high, native of the south-western
provinces of China; introduced at an early period into Japan by the
Buddhists and planted about their temples.

Kämpfer in his travels in Japan, in 1690-1692, discovered and figured a
tree called _Somo_ or _Skimmi_[94] which subsequent authors assumed to
be the source of the drug Star-anise. The tree was also found in Japan
by Thunberg[95] who remarked that its capsules are not so aromatic as
those found in trade. Von Siebold in 1825 noticed the same fact, in
consequence of which he regarded the tree as distinct from that of
Loureiro, naming it _Illicium Japonicum_, a name he changed in 1837
to _I. religiosum_. Baillon,[96] while admitting certain differences
between the fruits of the Chinese and Japanese trees, holds them to
constitute but one species, and the same view is taken by Miquel.[97]

[93] From the Arabic _Bádiyán fennel_.

[94] _Amœnitates_, 1712. 880.

[95] _Flora Japonica_, 1784. 235.

[96] _Adansonia_, vHist. des Plantes, Magnoliacées_, 1868. 154.

[97] _Ann. Mus. Bot._ Lugdun. Batav. ii. (1865-1866). 257.

The star-anise of commerce is produced in altitudes of 2500 metres in
the north-western parts of the province of Yunnan in South-western
China where the tree, which attains a height of 12 to 15 feet, grows in
abundance.[98] The fruits of the Japanese variety of the tree are not
collected, and the Chinese drug alone is in use even in Japan.

=History=—Notwithstanding its striking appearance, there is no evidence
that star-anise found its way to Europe like other Eastern spices
during the middle ages. Concerning its ancient use in China, the only
fact we have found recorded is, that during the Sung dynasty, A.D.
970-1127, star-anise was levied as tribute in the southern part of
Kien-chow, now Yen-ping-fu, in Fokien.[99]

Star-anise was brought to England from the Philippines by the
voyager Candish, about A.D. 1588. Clusius obtained it in London from
the apothecary Morgan and the druggist Garet, and described it in
1601.[100] The drug appears to have been rare in the time of Pomet,
who states (1694) that the Dutch use it to flavour their beverages of
tea and “sorbec.”[101] In those times it was brought to Europe by way
of Russia, and was thence called _Cardamomum Siberiense_, or _Annis de
Sibérie_.

=Description=—The fruit of _Illicium anisatum_ is formed of 8
one-seeded carpels, originally upright, but afterwards spread into
a radiate whorl and united in a single row round a short central
column which proceeds from an oblique pedicel. When ripe they are
woody and split longitudinally at the upturned ventral suture, so
that the shining seed becomes visible. This seed, which is elliptical
and somewhat flattened, stands erect in the carpel; it is truncated
on the side adjoining the central column, and is there attached by
an obliquely-rising funicle. The upper edge of the seed is keeled,
the lower rounded. The boat-shaped carpels, to the number of 8, are
attached to the column through their whole height, but adhere to each
other only slightly at the base; the upper or split side of each carpel
occupies a nearly horizontal position. The carpels are irregularly
wrinkled, especially below, and are more or less beaked at the apex;
their colour is a rusty brown. Internally they are of a brighter
colour, smooth, and with a cavity in the lower half corresponding to
the shape of the seed. The cavity is formed of a separate wall, ½
millim. thick, which, as well as the testa of the seed, distinctly
exhibits a radiate structure. The small embryo lies next the hilum in
the soft albumen, which is covered by a dark brown endopleura. The
seed, which is not much aromatic, amounts to about one-fifth of the
entire weight of the fruit.

[98] Thorel, _Notes Médicales du voyage d’exploration du Mékong et
de Cochinchine_, Paris, 1870. 31.—Garnier, _Voyage d’exploration en
Indo-Chine II._ (Paris, 1873) 439.—Rondot, _Etude pratique du commerce
d’exportation de la Chine_, 1848. 11.

[99] Bretschneider in (Foochow) _Chinese Recorder_, Jan., 1871, 220,
reprinted in his “Study and Value of Chinese Botanical Works,” Foochow,
1872, 13.—See also Hirth du Frênes, in _New Remedies_, New York, 1877,
181.

[100] _Rarior. Plant. Hist._ 202.

[101] _Hist. des Drog._ pt. i. liv. i. 43.

Star-anise has an agreeable aromatic taste and smell, more resembling
fennel than anise, on which account it was at first designated
_Fœniculum Sinense_.[102] When pulverised, it has a subacid after-taste.

=Microscopic Structure=—The carpels consist of an external, loose,
dark brown layer and a thick inner wall, separated by fibro-vascular
bundles. The outer layer exhibits numerous large cells, containing
pale yellow volatile oil. The inner wall of the carpels consists of
woody prosenchyme in those parts which are exterior to the seed cavity,
and especially in the shining walls laid bare by the splitting of the
ventral suture. The inner surface of the carpel is entirely composed
of sclerenchyme. A totally different structure is exhibited by this
stony shell where it lines the cavity occupied by the seed. Here it
is composed of a single row of cells, consisting of straight tubes
exactly parallel to one another, more than 500 mkm. long, and 70
mkm. in diameter, placed vertically to the seed cavity; their porous
walls, marked with fine spiral striations, display splendid colours in
polarized light. The seed contains albumen and drops of fat. Starch is
wanting in star-anise, except a little in the fruit-stalk.

=Chemical Composition=—The volatile oil amounts to four or five per
cent. Its composition is that of the oils of fennel or anise. We
observed that oil of star-anise, as distilled by one of us, continued
fluid below 8° C. It solidified at that temperature as soon as a
crystal of anethol (see our article on Fructus Anisi) was brought in
contact with the oil. The crystallized mass began to melt again at
16° C. The oils of anise and star-anise possess no striking optical
differences, both deviating very little to the left. We are unable
to give any chemical characters by which they can be discriminated,
although they are distinguished by dealers; the oil of star-anise
imparts a somewhat different flavour, for instance, to drinks than that
produced by anise oil.

Star-anise is rich in sugar, which seems to be cane-sugar inasmuch as
it does not reduce alkaline cupric tartrate. An aqueous extract of the
fruit assumes, on addition of alcohol, the form of a clear mucilaginous
jelly, of which pectin is probably a constituent. The seeds contain a
large quantity of fixed oil.

=Commerce=—Star-anise is shipped to Europe and India from China. In
1872 Shanghai imported, mostly by way of Hong Kong 5273 peculs (703,066
lb.), a large proportion of which was re-shipped to other ports of
China.[103] According to Rondot (_l. c._) the best is first brought by
junks from Fokien to Canton, being exported from Tsiouen-tchou-fou.
A little is also collected in Kiangsi and Kuang-tung. The same drug,
under the name of _Bādiyāne-khatāi_ (i.e. _Chinese fennel_), is carried
by inland trade from China to Yarkand and thence to India, where it is
much esteemed.

=Uses=—Star-anise is employed to flavour spirits, the principal
consumption being in Germany, France, and Italy. It is not used in
medicine at least in England, except in the form of essential oil,
which is often sold for oil of aniseed.

[102] Redi, _Experimenta_, Amstelod. 1675, p. 172.

[103] _Returns of Trade at the Treaty Ports in China for 1872_, 4-8.




MENISPERMACEÆ.


RADIX CALUMBÆ.

_Radix Columba_; _Calumba or Colombo Root_; F. _Racine de Colombo_; G.
_Kalumbawurzel_, _Columbowurzel_.

=Botanical Origin=—_Jateorhiza palmata_ Miers[104] a diœcious perennial
plant, with large fleshy roots and herbaceous annual stems, climbing
over bushes and to the tops of lofty trees. The leaves are of large
size and on long stalks, palmate-lobed and membranous. The male flowers
are in racemose panicles a foot or more in length, setose-hispid at
least in their lower part, or nearly glabrous. The whole part is more
or less hispid with spreading setæ and glandular hairs.

It is indigenous to the forests of Eastern Africa between Ibo or Oibo,
the most northerly of the Portuguese settlements (lat. 12° 28′ S.), and
the banks of the Zambesi, a strip of coast which includes the towns
of Mozambique and Quilimane. Kirk found it (1860) in abundance at
Shupanga, among the hills near Morambala, at Kebrabasa and near Senna,
localities all in the region of the Zambesi. Peters[105] states that on
the islands of Ibo and Mozambique the plant is cultivated. In the Kew
Herbarium is a specimen from the interior of Madagascar.

The plant was introduced into Mauritius a century ago in the time of
the French governor Le Poivre, but seems to have been lost, for after
many attempts it was again introduced in 1825 by living specimens
procured from Ibo by Captain Owen.[106] It still thrives there in the
Botanical Garden of Pamplemousses.

It was taken from Mozambique to India in 1805 and afterwards cultivated
by Roxburgh in the Calcutta Garden, where however it has long ceased to
exist.

[104] Synonyms—_Menispermum palmatum_ Lamarck, _Cocculus palmatus_ DC,
_Menispermum Columba_ Roxb., _Jateorhiza Calumba_ Miers, _J. Miersii_
Oliv., _Chasmanthera Columba_ Baillon. As we thus suppress a species
admitted in recent works, it is necessary to give the following
explanation. _Menispermum palmatum_ of Lamarck, first described in
the _Encyclopédie méthodique_ in 1797 (iv. 99), was divided by Miers
into two species, _Jateorhiza palmata_ and _J. Calumba_. Oliver in his
_Flora of Tropical Africa_, i. (1868) 42, accepted the view taken by
Miers, but to avoid confusion abolished the specific name _palmata_,
substituting for it that of _Miersii_. At the same time he noticed
the close relationship of the two species, and suggested that further
investigation might warrant their union. The characters supposed to
distinguish them _inter se_ are briefly these:—In _J. palmata_, the
lobes at the base of the leaf _overlap_, and the male inflorescence is
nearly glabrous; while in _J. Calumba_, the basal lobes are rounded,
but _do not overlap_, and the male inflorescence is setose-hispid
(“_sparsely pilose_” Miers). On careful examination of a large number
of specimens, including those of Berry from Calcutta, and others from
Mauritius, Madagascar, and the Zambesi, together with the drawings of
Telfair and Roxburgh, and the published figures and descriptions, I
am convinced that the characters in question are unimportant and do
not warrant the establishment of two species. In this view I have the
support of Mr. Horne of Mauritius, who at my request has made careful
observations on the living plant and found that both forms of leaf
occur on the same stem.—D. H.

[105] _Reise nach Mossambique_, Botanik i. (1862) 172.

[106] Hooker, _Bot. Mag._ lvii. (1830) tabb. 2970-71.

=History=—The root is held in high esteem among the natives of Eastern
Africa who call it _Kalumb_, and use it for the cure of dysentery and
as a general remedy for almost any disorder.

It was brought to Europe by the Portuguese in the 17th century, and is
first noticed briefly in 1671 by Francesco Redi, who speaks of it[107]
as an antidote to poison deserving trial.

No further attention was paid to the drug for nearly a century, when
Percival[108] in 1773 re-introduced it as “_a medicine of considerable
efficacy ... not so generally known in practice as it deserves to be_.”
From this period it began to come into general use. J. Gurney Bevan,
a London druggist, writing to a correspondent in 1777 alludes to it
as—“an article not yet much dealt in and subject to great fluctuation.”
It was in fact at this period extremely dear, and in Mr. Bevan’s
stock-books is valued in 1776 and 1777 at 30_s._ per lb., in 1780 at
28_s._, 1781 at 64_s._, 1782 at 15_s._, 1783 at 6_s._ Calumba was
admitted to the _London Pharmacopœia_ in 1788.

=Collection=—As to the collection and preparation of the drug for the
market, the only account we possess is that obtained by Dr. Berry,[109]
which states that the roots are dug up in the month of March, which is
the dry season, cut into slices and dried in the shade.

=Description=—The calumba plant produces great fusiform fleshy roots
growing several together from a short head. Some fresh specimens sent
to one of us (H.) from the Botanic Garden, Mauritius, in 1866, and
others from that of Trinidad in 1868, were portions of cylindrical
roots, 3 to 4 inches in diameter, externally rough and brown and
internally firm, fleshy, and of a brilliant yellow. When sliced
transversely, and dried by a gentle heat, these roots exactly resemble
imported calumba except for being much fresher and brighter.

The calumba of commerce consists of irregular flattish pieces of a
circular or oval outline, 1 to 2 inches or more in diameter, and ⅛ to
½ an inch thick. In drying, the central portion contracts more than
the exterior: hence the pieces are thinnest in the middle. The outer
edge is invested with a brown wrinkled layer which covers a corky bark
about ⅜ of an inch thick, surrounding a pithless internal substance,
from which it is separated by a fine dark shaded line. The pieces are
light and of a corky texture, easily breaking with a mealy fracture.
Their colour is a dull greenish yellow, brighter when the outer surface
is shaved off with a knife.[110] The drug has a weak musty odour and
a rather nauseous bitter taste. It often arrives much perforated by
insects, but seems not liable to such depredations here.

[107] “Sono ancora da farsi nuove esperienze intorno alla _radice di
Calumbe_, creduta un grandissimo alessifarmaco.”—_Esperienze_, p. 125.
(See Appendix, R.)

[108] _Essays Medical and Experimental_, Lond. ii. (1773) 3.

[109] _Asiatick Researches_, x. (1808) 385; Ainslie, _Mat. Med. of
Hindoostan_, 298.

[110] Wholesale druggists sometimes _wash_ the drug to improve its
colour.

=Microscopic Structure=—On a transverse section the root exhibits
a circle of radiate vascular bundles only in the layer immediately
connected with the cambial zone; they project much less distinctly
into the cortical part. The tissue of the whole root, except the cork
and vascular bundles, is made up of large parenchymatous cells. In
the outer part of the bark,— some of them have their yellow walls
thickened and are loaded with fine crystals of oxalate of calcium,
whilst all the other cells contain very large starch granules,
attaining as much as 90 mkm. The short fracture of the root is due to
the absence of a proper ligneous or liber tissue.

=Chemical Composition=—The bitter taste of calumba, and probably
likewise its medicinal properties, are due to three distinct
substances, _Columbin_, _Berberine_, and _Columbic Acid_.

_Columbin_, or _Columba-Bitter_ was discovered by Wittstock in 1830.
It is a neutral bitter principle, crystallizing in colourless rhombic
prisms, slightly soluble in cold alcohol or ether, but dissolving more
freely in those liquids when boiling. It is soluble in aqueous alkalis
and in acetic acid.

The presence of _Berberine_ in calumba was ascertained in 1848 by
Bödeker, who showed that the yellow cell-walls of the root owe their
colour to it and (as we may add) to _Columbic Acid_, another substance
discovered by the same chemist in the following year. Columbic Acid is
yellow, amorphous, nearly insoluble in cold water, but dissolving in
alcohol and in alkaline solutions. It tastes somewhat less bitter than
columbin. Bödeker surmises that it may exist in combination with the
berberine.

Bödeker has pointed out a connection between the three bitter
principles of calumba. If we suppose a molecule of ammonia, NH₃, to be
added to columbin C₄₂H₄₄O₁₄, the complex molecule thence resulting will
contain the elements of berberine C₂₀H₁₇NO₄, columbic acid C₂₂H₂₄O₇,
and water 3H₂O.

Among the more usual constituents of plants, calumba contains (in
addition to starch) pectin, gum, and nitrate of potassium, but no
tannic acid. It yields when incinerated 6 per cent. of ash.

=Commerce=—Calumba root is shipped to Europe and India from Mozambique
and Zanzibar, and exported from Bombay and other Indian ports.

=Uses=—It is much employed as a mild tonic, chiefly in the form of
tincture or of aqueous infusion.


PAREIRA BRAVA.

_Radix Pareiræ_; _Pareira-Brava_[111]; F. _Racine de Butua ou de
Pareira-Brava_; G. _Grieswurzel_.

=Botanical Origin=—_Chondodendron tomentosum_ Ruiz et Pav. (non
Eichler) (_Cocculus Chondodendron_ DC., _Botryopsis platyphylla_
Miers[112]).—It is a lofty climbing shrub with long woody stems, and
leaves as much as a foot in length. The latter are of variable form,
but mostly broadly ovate, rounded or pointed at the extremity, slightly
cordate at the base, and having long petioles. They are smooth on the
upper side; on the under covered between the veins with a fine close
tomentum of an ashy hue. The flowers are unisexual, racemose, minute,
produced either from the young shoots or from the woody stems. The
fruits are ¾ of an inch long, oval, black and much resembling grapes in
form and arrangement.[113]

[111] From the Portuguese _parreira_, signifying a vine that grows
against a wall (in French _treille_), and _brava_, wild.

[112] For a figure see Bentley and Trimen, _Medic. Plants_, Part 5
(1876); also Eichler in Martius’ _Flor. Bras._ fasc. 38. tab. 48. The
_Cissampelos Abutua_ of Vellozo’s _Flora Fluminensis_, tom. x. tab. 140
appears to us the same plant.

[113] See _Pharm. Journ._ Aug. 2, 1873. 83; _Yearbook_, 1873. 28; _Am.
Journ. of Pharm_. Oct. 1, 1873. fig. 3; _Hanbury Science Papers_. 382.

The plant grows in Peru and Brazil,—in the latter country in the
neighbourhood of Rio de Janeiro, where it occurs in some abundance on
the range of hills separating the Copacabana from the basin of the Rio
de Janeiro. It is also found about San Sebastian further south.

=History=—The Portuguese missionaries who visited Brazil in the 17th
century became acquainted with a root known to the natives as _Abutua_
or _Butua_, which was regarded as possessing great virtues. As the
plant affording it was a tall climbing shrub with large, simple,
long-stalked leaves, and bore bunches of oval berries resembling
grapes, the Portuguese gave it the name of _Parreira brava_ or Wild
Vine.

The root was brought to Lisbon where its reputed medicinal powers
attracted the notice of many persons, and among others of Michel
Amelot, ambassador of Louis XIV., who took back some of it when he
returned to Paris in 1688. Specimens of the drug also reached the
botanist Tournefort, and one presented by him to Pomet was figured
and described by the latter in 1694.[114] The drug was again brought
to Paris by Louis-Raulin Rouillé, the successor to Amelot at Lisbon,
together with a memoir detailing its numerous virtues.

Specimens obtained in Brazil by a naval officer named De la Mare in the
early part of the last century, were laid before the French Academy,
which body requested a report upon them from Geoffroy, professor
of medicine and pharmacy in the College of France, who was already
somewhat acquainted with the new medicine. He reported many favourable
trials in cases of inflammations of the bladder and suppression
of urine.[115] The drug was a favourite remedy of Helvetius,[116]
physician to Louis XIV. and Louis XV., who administered it for years
with great success.

Both Geoffroy and Helvetius were in frequent correspondence with
Sloane[117] who received from the former as well as from other
sources specimens of Pareira Brava, which are still in the British
Museum and have enabled us fully to identify the drug as the root of
_Chondodendron tomentosum_.

Several other plants of the order _Menispermaceæ_ have stems or roots
employed in South America in the same manner as _Chondodendron_. Pomet
had heard of two varieties of Pareira Brava, and two were known to
Geoffroy.[118] Lochner of Nürnberg who published a treatise on Pareira
Brava in 1719[119] brought forward a plant of Eastern Africa figured in
1675 by Zanoni,[120] and supposed to be the mother plant of the drug. A
species of _Cissampelos_ called by the Portuguese in Brazil _Caapeba_,
_Cipó de Cobras_ or _Herva de Nossa Senhora_ described by Piso in
1648,[121] afterwards became associated with Pareira Brava on account
of similarity of properties.

[114] _Hist. des Drog._ Paris, 1694. part i. livre 2. cap. 14.

[115] _Hist. de l’Acad. roy. des Sciences_, anneé 1710. 56.

[116] _Traité des maladies les plus fréquentes et des remèdes
spécifiques pour les guérir_, Paris, 1703. 98.

[117] In the volumes of Sloane MSS. No. 4045 and 3322 contained
in the British Museum, are a great many letters to Sloane from
Etienne-François Geoffroy and from his younger brother Claude-Joseph,
dating 1699 to 1744.

[118] _Tract. de Mat. Med._ ii. (1741) 21-25.

[119] _Schediasma de Parreira Brava_, 1719. (ed. 2. auctior.)

[120] _Istoria Botanica_, 1675. 59. fig. 22.

[121] _Medicina Brasiliensis_, 1648. 94.

Thus was introduced a confusion which we may say was _consolidated_
when Linnæus in 1753,[122] founded a species as _Cissampelos Pareira_,
citing it as the source of Pareira Brava,—a confusion which has lasted
for more than a hundred years. This plant is very distinct from that
yielding true Pareira Brava, and though its roots and stems are used
medicinally in the West Indies,[123] there is nothing to prove that
they were ever an object of export to Europe.

As Pareira Brava failed to realise the extravagant pretensions claimed
for it, it gradually fell out of use,[124] and the characters of the
true drug became forgotten. This at least seems to be the explanation
of the fact that for many years past the Pareira Brava found in the
shops and supposed to be genuine is a substance very diverse from the
original drug,—albeit not devoid of medicinal properties. More recently
even this has become scarce, and an inert Pareira Brava has been almost
the sole kind obtainable. The true drug has however still at times
appeared in the European market, and attention having been directed to
it,[125] we may hope that it will arrive in a regular manner.

The re-introduction of Pareira Brava into medical practice is due (so
far as Great Britain is concerned) to Brodie[126] who recommended it in
1828 for inflammation of the bladder.

=Description=—True Pareira Brava as derived from _Chondodendron
tomentosum_ is a long, branching, woody root, attaining 2 inches or
more in diameter, but usually met with much smaller and dividing into
rootlets no thicker than a quill or even than a horse-hair. It is
remarkably tortuous or serpentine and marked with transverse ridges as
well as with constrictions and cracks more or less conspicuous; besides
which the surface is strongly wrinkled longitudinally. The bark is of
a dark blackish brown or even quite black when free from earth, and
disposed to exfoliate. The root breaks with a coarse fibrous fracture;
the inner substance is of a light yellowish-brown,—sometimes of a dull
greenish brown.

Roots of about an inch in diameter cut transversely exhibit a central
column 0·2 to 0·4 of an inch in diameter composed of 10 to 20
converging wedges of large-pored woody tissue with 3 or 4 zones divided
from each other by a wavy light-coloured line. Crossing these zones
are wedge-shaped woody rays, often rather sparsely and irregularly
distributed. The interradial substance has a close, resinous, waxy
appearance.

[122] _Species Plantarum_, Holmiæ, 1753; see also _Mat. Med._ 1749. No.
459.

[123] Lunan, _Hort. Jamaic._ ii. (1814) 254; Descourtilz, _Flor. méd.
des Antilles_, iii. (1827) 231.

[124] Thus it was omitted from the London pharmacopœias of 1809 and
1824, and from many editions of the _Edinburgh Dispensatory_.

[125] Hanbury in _Pharm. Journ._ Aug. 2-9, 1873, pp. 81 and 102.

[126] _Lond. Med. Gazette_, Feb. 16, 1828; Brodie, _Lectures on
Diseases of the Urinary Organs_, ed. 3. 1842. 108, 138.

The root though hard is easily shaved with a knife, some pieces giving
the impression when cut of a waxy, rather than of a woody and fibrous
substance. The taste is bitter, well marked but not persistent. The
drug has no particular odour. Its aqueous decoction is turned inky
bluish-black by tincture of iodine.

The aerial stems especially differ by enclosing a small but
well-defined pith.

=Microscopic Structure=—The most interesting character consists in the
arrangement rather than in the peculiarity of the tissues composing
this drug. The wavy light-coloured lines already mentioned are built up
partly of sclerenchymatous cells. The other portions of the parenchyme
are loaded with large starch granules, which are much less abundant in
the stem.

=Chemical Composition=—From the examination of this drug made by one
of us in 1869,[127] it was shown that the bitter principle is the same
as that discovered in 1839 by Wiggers in the drug hereafter described
as _Common False Pareira Brava_, and named by him _Pelosine_. It was
further pointed out that this body possesses the chemical properties
of the _Bibirine_ of Greenheart bark and of the _Buxine_ obtained by
Walz from the bark of _Buxus sempervirens_ L. It was also obtained
on the same occasion (1869) from the stems and roots of _Cissampelos
Pareira_ L. collected in Jamaica; but from both drugs in the very small
proportion of about ½ per cent.

Whether to _Buxine_ (for by this name rather than _Pelosine_ it should
be designated) is due the medicinal power of the drug may well be
doubted. No further chemical examination of true Pareira Brava has been
made.

=Uses=—The medicine is prescribed in chronic catarrhal affections of
the bladder and in calculus. From its extensive use in Brazil[128] it
seems deserving of trial in other complaints. Helvetius used to give it
in substance, which in 5-grain doses was taken in infusion made with
boiling water from the powdered root and not strained.

=Substitutes=—We have already pointed out how the name _Pareira Brava_
has been applied to several other drugs than that described in the
foregoing pages. We shall now briefly notice the more important.

1. _Stems and roots of Cissampelos Pareira_ L.—Owing to the difficulty
of obtaining good Pareira Brava in the London market, although this
plant is very widely diffused over all the tropical regions of both
hemispheres, the firm of which one of us was formerly a member
(Messrs. Allen and Hanburys, Plough Court, Lombard Street) caused to
be collected in Jamaica, under the superintendence of Mr. N. Wilson,
of the Bath Botanical Gardens, the stems and root of _Cissampelos
Pareira_ L., of which it imported in 1866-67-68 about 300 lb. It was
found impracticable to obtain the root _per se_; and the greater bulk
of the drug consisted of long cylindrical stems,[129] many of which
had been decumbent and had thrown out rootlets at the joints. They had
very much the aspect of the climbing stems of _Clematis vitalba_ L.,
and varied from the thickness of a quill to that of the forefinger,
seldom attaining the diameter of an inch. The stems have a light brown
bark marked longitudinally with shallow furrows and wrinkles, which
sometimes take a spiral direction. Knots one to three feet apart,
sometimes throwing out a branch, also occur. The root is rather darker
in colour, but not very different in structure from the stem.

[127] _Neues Jahrb. f. Pharm._ xxxi. (1869) 257; _Pharm. Journ._ xi.
(1870) 192.

[128] “Presentamente (Abutua) é reputada diaphoretica, diuretica e
emenagoga, e usada interiormente na dóse de duas a quatro oitavas
para uma libra de infusão ou cozimento, nas febres intermittentes,
hydropisias, e suspensão de lochios.”—Langgaard, _Diccionario de
Medicina domestica e popular_, Rio de Janeiro, i. (1865) 17.

[129] Figured, together with the plant, in Bentley and Trimen, _Medic.
Plants_, part 9 (1876).

The fracture of the stem is coarse and fibrous. The transverse section,
whether of stem or root, shows a thickish, corky bark surrounding a
light brown wood composed of a number of converging wedges (10 to 20)
of very porous structure, separated by narrow medullary rays. There
are _no concentric layers_ of wood,[130] nor is the arrangement of
the wedges oblique as in many other stems of the order. The drug is
inodorous, but has a very bitter taste without sweetness or astringency.

[130] It is therefore entirely different to the wood figured as that of
_C. Pareira_ by Eichler in Martius’ _Flor. Bras._ xiii. pars. i. tab.
50. fig. 7.

2. _Common False Pareira Brava_—Under this name we designate the drug
which for many years past has been the ordinary Pareira Brava of the
shops, and regarded until lately as derived from _Cissampelos Pareira_
L. We have long endeavoured to ascertain, through correspondents in
Brazil, from what plant it is derived, but without success. We only
know that it belongs to the order _Menispermaceæ_.

The drug consists of a ponderous, woody, tortuous stem and root,
occurring in pieces from a few inches to a foot or more in length,
and from 1 to 4 inches in thickness, coated with a thin, hard, dark
brown bark. The pieces are cylindrical, four-sided, or more or less
flattened—sometimes even to the extent of becoming ribbon-like. In
transverse section, their structure appears very remarkable. Supposing
the piece to be _stem_, a well-defined pith will be found to occupy
the centre of the first-formed wood, which is a column about ¼ of an
inch in diameter. This is succeeded by 10 to 15 or more concentric or
oftener eccentric zones, ⅒ to ²/₁₀ of an inch wide, each separated from
its neighbour by a layer of parenchyme, the outermost being coated with
a true bark. In pieces of _true root_, the pith is reduced to a mere
point.

Sometimes the development of the zones has been so irregular that they
have formed themselves entirely on one side of the primitive column,
the other being coated with bark. The zones, including the layer,
around the pith (if pith is present), are crossed by numerous small
medullary rays. These do not run from the centre to the circumference,
but traverse only their respective zones, on the outside of which they
are arched together.

The drug, when of good quality, has its wood firm, compact, and of a
dusky yellowish-brown hue, and a well-marked bitter taste. It exhibits
under the knife nothing of the close waxy texture seen in the root of
_Chondodendron_, but cuts as a tough, fibrous wood. Its decoction is
not tinged blue by iodine. It was in this drug that Wiggers in 1839
discovered _pelosine_.

The drug just described, which is by no means devoid of medicinal
power, has of late years been almost entirely supplanted in the market
by another sort consisting exclusively of stems which are devoid of
bitterness and appear to be wholly inert. They are in the form of
sticks or truncheons, mostly cylindrical. Cut traversely, they display
the same structure as the sort last described, with a well-defined
pith. The wood is light in weight, of a dull tint, and disposed to
split. The bark, which consists of two layers, is easily detached.

3. _Stems of Chondodendron tomentosum_ R. et P.—These have been
recently imported from Brazil, and sold as _Pareira Brava_.[131] The
drug consists of truncheons about 1½ feet in length, of a rather rough
and knotty stem, from 1 to 4 inches thick.[132] The larger pieces,
which are sometimes hollow with age, display, when cut traversely, a
small number (5-9) nearly concentric woody zones. The youngest pieces
have the bark dotted over with small dark warts.

The wood is inodorous, but has a bitterish taste like the root, of
which it is probably an efficient representative. Some pieces have
portions of root springing from them, and detached roots occur here
and there among the bits of stem. The structure and development of the
latter has been elaborately examined and figured by Moss,[133] and also
by Lanessan,[134] in the French translation of our book.

4. _White Pareira Brava_—Stems and roots of _Abuta rufescens_
Aublet.—Mr. J. Correa de Méllo of Campinas has been good enough to
send to one of us (H.) a specimen of the root and leaves[135] of this
plant, marked _Parreira Brava grande_. The former we have identified
with a drug received from Rio de Janeiro as _Abutua Unha de Vaca_, i.e.
_Cowhoof Abutua_, and also with a similar drug found in the London
market. Aublet[136] states that the root of _Abuta rufescens_ was, in
the time of his visit to French Guiana, shipped from that colony to
Europe as _Pareira Brava Blanc_ (White Pareira Brava).

[131] 45 packages containing about 20 cwt. were offered for sale by
Messrs. Lewis and Peat, drug-brokers, 11 Sept. 1873, but there had been
earlier importations.

[132] From these knots, which are at regular intervals, and sometimes
very protuberant, it would appear that the panicles of flower arise
year after year.

[133] _Pharm. Journ._ vi. (1876) 702.

[134] _Histoire des Drogues d’origine végétale_, i. (Paris, 1878) 72.

[135] I have compared these leaves with Aublet’s own specimen in the
British Museum.—D. H.

[136] _Hist. des Plantes de la Guiane Françoise_, i. (1775) 618. tab.
250.

This name is well applicable to the drug before us, which consists of
short pieces of a root, ½ an inch to 3 inches thick, covered with a
rough blackish bark, and also of bits of stem having a pale, striated,
corky bark. Cut transversely, the root displays a series of concentric
zones of white amylaceous cellular tissue, each beautifully marked with
narrow wedge-shaped medullary rays of dark, porous tissue. The wood of
the stem is harder than that of the root, the medullary rays are closer
together and broader, and there is a distinct pith.

The wood, neither of root nor stem, has any taste or smell. A decoction
of the root is turned bright blue by iodine.

5. _Yellow Pareira Brava_—This drug, of which a quantity was in the
hands of a London drug-broker in 1873, is, we presume, the _Pareira
Brava jaune_ of Aublet—the bitter tasting stem of his “_Abuta amara_
folio levi cordiformi ligno flavescente,”—a plant of Guiana unknown to
recent botanists. That which we have seen consists of portions of a
hard woody stem, from 1 to 5 or 6 inches in diameter, covered with a
whitish bark. Internally it is marked by numerous regular concentric
zones, is of a bright yellow colour and of a bitter taste. It contains
berberine. The same drug, apparently, was exhibited in the Paris
exposition of 1878 as “Liane amère” from French Guiana.


COCCULUS INDICUS.

_Fructus Cocculi_; _Cocculus Indicus_; F. _Coque du Levant_; G.
_Kokkelskörner_.

=Botanical Origin=—_Anamirta paniculata_ Colebrooke, 1822 (_Menispermum
Cocculus_ L.; _Anamirta Cocculus_ Wight et Arnott, 1834), a strong
climbing shrub found in the eastern parts of the Indian peninsula from
Concan and Orissa to Malabar and Ceylon, in Eastern Bengal, Khasia and
Assam, and in the Malayan Islands.

=History=—It is commonly asserted that _Cocculus Indicus_ was
introduced into Europe through the Arabs, but the fact is difficult of
proof; for though Avicenna[137] and other early writers mention a drug
having the power of poisoning fish, they describe it as a _bark_, and
make no allusion to it as a production of India. Even Ibn Baytar[138]
in the 13th century professed his inability to discover what substance
the older Arabian authors had in view.

Cocculus Indicus is not named by the writers of the School of Salerno.
The first mention of it we have met with is by Ruellius,[139] who,
alluding to the property possessed by the roots of _Aristolochia_ and
_Cyclamen_ of attracting fishes, states that the same power exists
in the little berries found in the shops under the name of _Cocci
Orientis_, which when scattered on water stupify the fishes, so that
they may be captured by the hand.

Valerius Cordus[140] thought the drug which he calls _Cuculi de
Levante_ to be the fruit of a _Solanum_ growing in Egypt.

Dalechamps[141] repeated this statement in 1586, at which period
and for long afterwards, Cocculus Indicus used to reach Europe from
Alexandria and other parts of the Levant. Gerarde,[142] who gives
a very good figure of it, says it is well known in England (1597)
as _Cocculus Indicus_, otherwise _Cocci_ vel _Cocculæ Orientales_,
and that it is used for destroying vermin and poisoning fish. In
1635 it was subject to an import duty of 2_s._ per lb., as _Cocculus
Indiæ_.[143]

The use of Cocculus Indicus in medicine was advocated by Battista
Codronchi, a celebrated Italian physician of the 16th century, in a
tractate entitled _De Baccis Orientalibus_.[144] In the “Pinax” Caspar
Bauhin (about 1660) states that _Cocculæ officinarum_ “saepe racematim
pediculis hærentes, hederæ corymborum modo, ex Alexandria adferuntur.”

[137] Valgrisi edition, 1564. lib. ii. tract. 2. cap. 488.

[138] Sontheimer’s transl. ii. 460.

[139] _De Natura Stirpium_, Paris, 1536. lib. iii. c. 4.

[140] _Adnotationes_, 1549. cap. 63 (p. 509).

[141] _Hist. Gen. Plant._ 1586. 1722.

[142] _Herball_, Lond. 1636. 1548-49.

[143] _The Rates of Marchandizes_, Lond. 1635.

[144] It forms part of his work _De Christiana ac tuta medendi
ratione_, Ferrariæ, 1591.

The word _Cocculus_ is derived from the Italian _coccola_, signifying a
small, berry-like fruit.[145] Mattioli remarks that as the berries when
first brought from the East to Italy had no special name, they got to
be called _Coccole di Levante_.[146]

=Description=—The female flower of _Anamirta_ has normally 5 ovaries
placed on a short gynophore. The latter, as it grows, becomes raised
into a stalk about ½ an inch long, articulated at the summit with
shorter stalks, each supporting a drupe, which is a matured ovary. The
purple drupes thus produced are 1 to 3 in number, of gibbous ovoid
form, with the persistent stigma on the straight side, and in a line
with the shorter stalk or carpodium. They grow in a pendulous panicle,
a foot or more in length.

These fruits removed from their stalks and dried have the aspect of
little round berries, and constitute the Cocculus Indicus of commerce.
As met with in the market they are shortly ovoid or subreniform,
⁴/₁₀ to ⁵/₁₀ of an inch long, with a blackish, wrinkled surface, and
an obscure ridge running round the back. The shorter stalk, when
present, supports the fruit very obliquely. The pericarp, consisting
of a wrinkled skin covering a thin woody endocarp, encloses a single
reniform seed, into which the endocarp deeply intrudes. In transverse
section the seed has a horseshoe form; it consists chiefly of albumen,
enclosing a pair of large, diverging lanceolate cotyledons, with a
short terete radicle.[147]

The seed is bitter and oily, the pericarp tasteless. The drug is
preferred when of dark colour, free from stalks, and fresh, with the
seeds well-preserved.

=Microscopic Structure=—The woody endocarp is built up of a peculiar
sclerenchymatous tissue, consisting of branched, somewhat elongated
cells. They are densely packed, and run in various directions,
showing but small cavities. The parenchyme of the seed is loaded with
crystallized fatty matter.

=Chemical Composition=—_Picrotoxin_, a crystallizable substance
occurring in the seed to the extent of ⅖ to 1 per cent., was observed
by Boullay, as early as 1812, and is the source of the poisonous
property of the drug. Picrotoxin does not neutralize acids. It
dissolves in water and in alkalis; the solution in the latter reduces
cupric or bismutic oxide like the sugars, but to a much smaller extent
than glucose. The alcoholic solutions deviate the ray of polarized
light to the left. The aqueous solution of picrotoxin is not altered
by any metallic salt, or by tannin, iodic acid, iodohydrargyrate or
bichromate of potassium—in fact by none of the reagents which affect
the alkaloids. It may thus be easily distinguished from the bitter
poisonous alkaloids, although in its behaviour with concentrated
sulphuric acid and bichromate of potassium it somewhat resembles
strychnine, as shown in 1867 by Köhler.

[145] Frutto d’alcuni alberi, e d’alcune piante, o erbe salvatiche,
come cipresso, ginepro, alloro, pugnitopo, e lentischio, e simili.—Lat.
_bacca_; Gr. ἀκρόδρνα.—_Vocabolario degli Accademici della Crusca._

[146] Quoted by J. J. von Tschudi, _Die Kokkelskörner und das
Pikrotoxin_, St. Gallen, 1847.

[147] The fruit should be macerated in order to examine its structure.

Picrotoxin melts at 200° C.; its composition, C₉H₁₀O₄, as ascertained
in 1877 by Paternò and Oglialoro, is the same as that of everninic,
hydrocoffeïc, umbellic and veratric (or dimethyl-protocatechuic
acid—see Semen Sabadillæ) acids.

Pelletier and Couerbe (1833) obtained from the pericarp of Cocculus
Indicus two crystallizable, tasteless, non-poisonous substances,
having the same composition, and termed respectively _Menispermine_
and _Paramenispermine_. These bodies, as well as the very doubtful
amorphous _Hypopicrotoxic Acid_ of the same chemists, require
re-examination.

The fat of the seed, which amounts to about half its weight, is used in
India for industrial purposes. Its acid constituent, formerly regarded
as a peculiar substance under the name of _Stearophanic_ or _Anamirtic
Acid_, was found by Heintz to be identical with stearic acid.

=Commerce=—Cocculus Indicus is imported from Bombay and Madras, but
we have no statistics showing to what extent. The stock in the dock
warehouses of London on 1st of December, 1873, was 1168 packages,
against 2010 packages on the same day of the previous year. The drug is
mostly shipped to the Continent, the consumption in Great Britain being
very small.

=Uses=—In British medicine Cocculus Indicus is only employed as an
ingredient of an ointment for the destruction of _pediculi_. It has
been discarded from the _British Pharmacopœia_, but has a place in that
of India.


GULANCHA.

_Caulis et radix Tinosporæ._

=Botanical Origin=—_Tinospora cordifolia_ Miers (_Cocculus cordifolius_
DC.), a lofty climbing shrub found throughout tropical India from
Kumaon to Assam and Burma, and from Concan to Ceylon and the
Carnatic.[148] It is called in Hindustani _Gulancha_; in Bombay the
drug is known under the name of _Goolwail_.

=History=—The virtues of this plant which appear to have been long
familiar to the Hindu physicians, attracted the attention of Europeans
in India at the early part of the present century.[149] According to a
paper published at Calcutta in 1827,[150] the parts used are the stem,
leaves, and root, which are given in decoction, infusion, or a sort of
extract called _pálo_, in a variety of diseases attended with slight
febrile symptoms.

O’Shaughnessy declares the plant to be one of the most valuable in
India, and that it has proved a very useful tonic. Similar favourable
testimony is borne by Waring. Gulancha was admitted to the _Bengal
Pharmacopœia_ of 1844, and to the _Pharmacopœia of India_ of 1868.

=Description=—The stems are perennial, twining and succulent, running
over the highest trees and throwing out roots many yards in length
which descend like slender cords to the earth. They have a thick corky
bark marked with little prominent tubercles.

[148] Fig. in Bentley and Trimen, _Med. Plants_, part 13.

[149] Fleming, _Catal. of Indian Med. Plants and Drugs_, Calcutta,
1810. 27.

[150] On the native drug called _Gulancha_ by Ram Comol Shen.—_Trans.
of Med. and Phys. Soc. of Calcutta_, iii. (1827) 295.

As found in the bazaars the drug occurs as short transverse segments of
a cylindrical woody stem from ¼ of an inch up to 2 inches in diameter.
They exhibit a shrunken appearance, especially those derived from the
younger stems, and are covered with a smooth, translucent, shrivelled
bark which becomes dull and rugose with age. Many of the pieces are
marked with warty prominences and the scars of adventitious roots. The
outer layer which is easily detached covers a shrunken parenchyme.
The transverse section of the stem shows it to be divided by about
12 to 14 medullary rays into the same number of wedge-shaped woody
bundles having very large vessels, but no concentric structure. The
drug is inodorous but has a very bitter taste. The root is stated by
O’Shaughnessy[151] to be large, soft, and spongy.

=Microscopic Structure=—The suberous coat consists of alternating
layers of flat corky cells and sclerenchyme, sometimes of a yellow
colour. The structure of the central part reminds one of that of
_Cissampelos Pareira_ (p. 28), like which it is not divided into
concentric zones. The woody rays which are sometimes intersected by
parenchyme, are surrounded by a loose circle of arched bundles of liber
tissue.

=Chemical Composition=—No analysis worthy of the name has been made of
this drug, and the nature of its bitter principle is wholly unknown.
We have had no material at our disposal sufficient for chemical
examination.

=Uses=—Gulancha is reputed to be tonic, antiperiodic and diuretic.
According to Waring[152] it is useful in mild forms of intermittent
fever, in debility after fevers and other exhausting diseases, in
secondary syphilitic affections and chronic rheumatism.

=Substitute=—_Tinospora crispa_ Miers, an allied species occurring in
Silhet, Pegu, Java, Sumatra, and the Philippines, possesses similar
properties, and is highly esteemed in the Indian Archipelago as a
febrifuge.

[151] _Bengal Dispensatory_, 1842. 198.

[152] _Pharm. of India_, 1868. 9.




BERBERIDEÆ.


CORTEX BERBERIDIS INDICUS.

_Indian Barberry Bark._

=Botanical Origin=—This drug is allowed in the _Pharmacopœia of India_
to be taken indifferently from three Indian species of _Berberis_[153]
which are the following:—

1. _Berberis aristata_ DC., a variable species occurring in the
temperate regions of the Himalaya at 6000 to 10,000 feet elevation,
also found in the Nilgiri mountains and Ceylon.[154]

2. _B. Lycium_, Royle, an erect, rigid shrub found in dry, hot
situations of the western part of the Himalaya range at 3000 to 9000
feet above the sea-level.

[153] For remarks on the Indian species of _Berberis_, see Hooker
and Thomson’s _Flora Indica_ (1855), also Hooker’s _Flora of British
India_, i. (1872) 108.

[154] Fig. in Bentley and Trimen, _Med. Plants_, part 25.

3. _B. asiatica_ Roxb.—This species has a wider distribution than the
last, being found in the dry valleys of Bhutan and Nepal whence it
stretches westward along the Himalaya to Garhwal, and occurs again in
Afghanistan.

=History=—The medical practitioners of ancient Greece and Italy made
use of a substance called _Lycium_, (λύκιον) of which the best kind
was brought from India. It was regarded as a remedy of great value in
restraining inflammatory and other discharges; but of all the uses to
which it was applied the most important was the treatment of various
forms of ophthalmic inflammation.

Lycium is mentioned by Dioscorides, Pliny, Celsus, Galen, and
Scribonius Largus; by such later Greek writers as Paulus Ægineta,
Ætius, and Oribasius, as well as by the Arabian physicians.

The author of the Periplus of the Erythrean Sea who probably lived in
the 1st century, enumerates λύκιον as one of the exports of Barbarike
at the mouth of the Indus, and also names it along with Bdellium and
Costus among the commodities brought to Barygaza:—and further, lycium
is mentioned among the Indian drugs on which duty was levied at the
Roman custom-house of Alexandria about A.D. 176-180.[155]

An interesting proof of the esteem in which it was held is afforded
by some singular little vases or jars of which a few specimens are
preserved in collections of Greek antiquities.[156] These vases were
made to contain lycium, and in them it was probably sold; for an
inscription on the vessel not only gives the name of the drug but also
that of a person who, we may presume, was either the seller or the
inventor of the composition. Thus we have the _Lycium_ of _Jason_, of
_Musæus_, and of _Heracleus_. The vases bearing the name of Jason were
found at Tarentum, and there is reason to believe that that marked
_Heracleus_ was from the same locality. Whether it was so or not, we
know that a certain Heraclides of Tarentum is mentioned by Celsus[157]
on account of his method of treating certain diseases of the eye; and
that Galen gives formulæ for ophthalmic medicines[158] on the authority
of the same person.

Innumerable conjectures were put forth during at least three centuries
as to the origin and nature of lycium, and especially of that highly
esteemed kind that was brought from India.

In the year 1833, Royle[159] communicated to the Linnean Society of
London a paper proving that the Indian Lycium of the ancients was
identical with an extract prepared from the wood or root of several
species of _Berberis_ growing in Northern India, and that this extract,
well known in the bazaars as _Rusot_ or _Rasot_, was in common use
among the natives in various forms of eye disease.[160] This substance
attracted considerable notice in India, and though its efficacy _per
se_[161] seemed questionable, it was administered with benefit as a
tonic and febrifuge.[162] But the _rusot_ of the natives being often
badly prepared or adulterated, the bark of the root has of late been
used in its place, and in consequence of its acknowledged efficacy has
been admitted to the _Pharmacopœia of India_.

[155] Vincent, _Commerce and Navigation of the Ancients in the Indian
Ocean_, ii. (1807) 390, 410, 734.

[156] Figures of these vessels were published by Dr. J. Y. Simpson in
an interesting paper entitled _Notes on some ancient Greek medical
vases for containing Lycium_, of which we have made free use.—See
(_Edinb.)_ _Monthly Journal of Med. Science_, xvi. (1853) 24, also
_Pharm. Journ._ xiii. (1854) 413.

[157] Lib. vii. c. 7.—See also Cælius Aurelianus, _De morbis chronicis_
(Haller’s ed.) lib. i. c. 4, lib. iii. c. 8.

[158] Cataplasmata lippientium quibus usus est Heraclides
Tarentinus—Galen, _De Comp. Med. sec. locos_, lib. iv. (p. 153 in
Venice edit. of 1625).

[159] On the _Lycium_ of Dioscorides.—_Linn. Trans._ xvii. (1837) 83.

[160] It is interesting to find that two of the names for _lycium_
given by Ibn Baytar in the 13th century are precisely those under which
_rusot_ is met with in the Indian bazaars at the present day.

[161] The natives apply it in combination with alum and opium.

[162] O’Shaughnessy, _Bengal Dispensatory_ (1842) 203-205.

=Description.=—In _B. asiatica_ (the only species we have examined) the
roots which are thick and woody, and internally of a bright yellow, are
covered with a thin, brittle bark. The bark has a light-brown corky
layer, beneath which it appears of a darker and greenish yellow hue,
and composed of coarse fibres running longitudinally. The inner surface
has a glistening appearance by reason of fine longitudinal striæ. The
bark is inodorous and very bitter.

=Chemical Composition.=—Solly[163] pointed out in 1843 that the
root-bark of the Ceylon barberry [_B. aristata_] contains the same
yellow colouring matter as the barberry of Europe. L. W. Stewart[164]
extracted _Berberine_ in abundance from the barberry of theNilgiri
Hills and Northern India, and presented specimens of it to one of us in
1865.

The root-bark of _Berberis vulgaris_ L. was found by Polex (1836) to
contain another alkaloid named _Oxyacanthine_, which forms with acids
colourless crystallizable salts of bitter taste.[165]

=Uses.=—The root-bark of the Indian barberries administered as a
tincture has been found extremely useful in India in the treatment of
fevers of all types. It has also been given with advantage in diarrhœa
and dyspepsia, and as a tonic for general debility. In the collection
of the Chinese customs at Paris, in 1878, the root-barks of _Berberis
Lycium_ and _B. chinensis_, from the province of Shensi, were likewise
exhibited (No. 1,823) as a tonic.

[163] _Journ. of R. Asiat. Soc._ vii. (1843) 74.

[164] _Pharm. Journ._ vii. (1866) 303.

[165] Gmelin, _Chemistry_, xvii. (1866) 197.


RHIZOMA PODOPHYLLI.

_Radix podophylli_; _Podophyllum Root_.

=Botanical Origin=—_Podophyllum peltatum_ L., a perennial herb growing
in moist shady situations throughout the eastern side of the North
American continent from Hudson’s Bay to New Orleans and Florida.

The stem about a foot high, bears a large, solitary, white flower,
rising from between two leaves of the size of the hand composed of 5
to 7 wedge-shaped divisions, somewhat lobed and toothed at the apex.
The yellowish pulpy fruit of the size of a pigeon’s egg is slightly
acid and is sometimes eaten under the name of _May Apple_. The leaves
partake of the active properties of the root.

=History=—The virtues of the rhizome as an anthelminthic and emetic
have been long known to the Indians of North America. The plant was
figured in 1731 by Catesby[166] who remarks that its root is an
excellent emetic. Its cathartic properties were noticed by Schöpf[167]
and Barton[168] and have been commented upon by many subsequent
writers. In 1820, podophyllum was introduced into the _United States
Pharmacopœia_, and in 1864 into the _British Pharmacopœia_. Hodgson
published in 1832 in the _Journal of the Philadelphia College of
Pharmacy_[169] the first attempt of a chemical examination of the
rhizome, which now furnishes one of the most popular purgatives, the
so-called _Podophyllin_, manufactured on a large scale at Cincinnati
and in other places in America, as well as in England.

=Description=—The drug consists of the rhizome and rootlets. The
former creeps to a length of several feet, but as imported is mostly
in somewhat flattened pieces of 1 to 8 inches in length and 2 to 4
lines in longest diameter: it is marked by knotty joints showing a
depressed scar at intervals of a few inches which marks the place of a
fallen stem. Each joint is in fact the growth of one year, the terminal
bud being enclosed in papery brownish sheaths. Sometimes the knots
produce one, two, or even three lateral buds and the rhizome is bi-
or tri-furcate. The reddish-brown or grey surface is obscurely marked
at intervals by oblique wrinkles indicating the former attachment of
rudimentary leaves. The rootlets are about ½ a line thick and arise
from below the knots and adjacent parts of the rhizome, the internodal
space being bare. They are brittle, easily detached, and commonly of a
paler colour. The rhizome is mostly smooth, but some of the branched
pieces are deeply furrowed. Both rootstock and rootlets have a short,
smooth, mealy fracture; the transverse section is white, exhibiting
only an extremely small corky layer and a thin simple circle of about
20 to 40 yellow, vascular bundles, enclosing a central pith which in
the larger pieces is often 2 lines in diameter.

The drug has a heavy narcotic, disagreeable odour, and a bitter, acrid,
nauseous taste.

=Microscopic Structure=—The vascular bundles are composed of spiral and
scalariform vessels intermixed with cambial tissue. From each bundle a
narrow-tissued, wedge-or crescent-shaped liber-bundle projects a little
into the cortical layer. This, as well as the pith, exhibits large
thin-walled cells. The rootlets are as usual of a different structure,
their central part consisting of one group of vascular bundles more or
less scattered.[170] The parenchymatous cells of the drug are loaded
with starch granules; some also contain stellate tufts of oxalate of
calcium.

[166] _Nat. Hist. of Carolina_, i. tab. 24.

[167] _Materia Med. Americ._ Erlangæ, 1787, p. 86. Schöpf was physician
to German troops fighting in the War of Independence.

[168] _Collections for an Essay on Mat. Med. of U.S._ Philad. 1798, 31.

[169] Vol. iii. 273.

[170] Figured by Power, _Proc. American Phar. Assoc._, 1877. 420-433.

=Chemical Composition=—The active principles of podophyllum exist in
the resin, which according to Squibb[171] is best prepared by the
process termed _re-percolation_. The powdered drug is exhausted by
alcohol which is made to percolate through successive portions. The
strong tincture thus obtained is slowly poured into a large quantity
of water acidulated with hydrochloric acid (one measure of acid to
70 of water), and the precipitated resin dried at a temperature not
exceeding 32° C. The acid is used to facilitate the subsidence of the
pulverulent resin which according to Maisch settles down but very
slowly if precipitated by cold water simply, and if thrown down by hot
water fuses into a dark brown cake. The resin redissolved in alcohol
and again precipitated by acidulated water, after thorough washing with
distilled water and finally drying over sulphuric acid, amounts to
about 2 per cent.

[171] _American Journ. of Pharm._ xvi. (1868) 1-10.

Resin of podophyllum is a light, brownish-yellow powder with a tinge
of green, devoid of crystalline appearance, becoming darker if exposed
to a heat above 32° C., and having an acrid, bitter taste; it is very
incorrectly called _Podophyllin_. The product is the same whether the
rhizome or the rootlets are exclusively employed.[172] It is soluble
in caustic, less freely in carbonated alkalis, even in ammonia, and is
precipitated, apparently without alteration, on addition of an acid.
Ether separates it into two nearly equal portions, the one soluble in
the menstruum, the other not, but both energetically purgative. From
the statements of Credner[173] it appears that if caustic lye is shaken
with the ethereal solution, about half the resin combines with the
potash, while the other half remains dissolved in the ether. If an acid
is added to the potassic solution a red-brown precipitate is produced
which is no longer soluble in ether nor possessed of purgative power.
According to Credner, the body of greatest purgative activity was
precipitated by ether from an alcoholic solution of crude podophyllin.

By exhausting the resin with boiling water, Power found that finally
not more than 20 per cent. of the resin remained undissolved. By
melting the crude resin with caustic soda, a little protocatechuic acid
was obtained.

F. F. Mayer[174] of New York stated podophyllum to contain, beside
the resin already mentioned, a large proportion of _Berberine_, a
colourless alkaloid, an odoriferous principle which might be obtained
by sublimation in colourless scales, and finally _Saponin_. From all
these bodies the resin as prepared by Power,[175] was ascertained by
him to be destitute; he especially proved the absence of berberine in
Podophyllum.

=Uses=—Podophyllum is only employed for the preparation of the resin
(_Resina Podophylli_) which is now much prescribed as a purgative.

[172] Saunders in _Am. Journ. of Pharm._ xvi. 75.

[173] _Ueber Podophyllin_ (_Dissertation_), Giessen, 1869.

[174] _Am. Journ. of Pharmacy_, xxxv. (1863) 97.

[175] L. cit., also _Am. Journ. of Pharm._ (1878) 370.




PAPAVERACEÆ.


PETALA RHŒADOS.

_Flores Rhœados_; _Red Poppy Petals_; F. _Fleurs de Coquelicot_; G.
_Klatschrosen_.

=Botanical Origin=—_Papaver Rhœas_ L.—The common Red Poppy or Corn Rose
is an annual herb found in fields throughout the greater part of Europe
often in extreme abundance. It almost always occurs as an accompaniment
of cereal crops, frequently disappearing when this cultivation is given
up. It is plentiful in England and Ireland, but less so in Scotland;
is found abundantly in Central and Southern Europe and in Asia Minor,
whence it extends as far as Abyssinia, Palestine, and the banks of the
Euphrates. But it does not occur in India or in North America.

From the evidence adduced by De Candolle[176] it would appear that the
plant is strictly indigenous to Sicily, Greece, Dalmatia, and possibly
the Caucasus.

=History=—_Papaver Rhœas_ was known to the ancients, though doubtless
it was often confounded with _P. dubium_ L. the flowers of which are
rather smaller and paler. The petals were used in pharmacy in Germany
in the 15th century.[177]

=Description=—The branches of the stem are upright, each terminating
in a conspicuous long-stalked flower, from which as it opens the two
sepals fall off. The delicate scarlet petals are four in number,
transversely elliptical and attached below the ovary by very short,
dark violet claws. As they are broader than long, their edges overlap
in the expanded flower. In the bud they are irregularly crumpled,
but when unfolded are smooth, lustrous, and unctuous to the touch.
They fall off very quickly, shrink up in drying, and assume a
brownish-violet tint even when dried with the utmost care. Although
they do not contain a milky juice like the green parts of the plant,
they have while fresh a strong narcotic odour and a faintly bitter
taste.

=Chemical Composition=—The most important constituent of the petals
is the colouring matter, still but very imperfectly known. According
to L. Meier (1846) it consists of two acids, neither of which could
be obtained other than in an amorphous state. The colouring matter is
abundantly taken up by water or spirit of wine but not by ether. The
aqueous infusion is not precipitated by alum, but yields a dingy violet
precipitate with acetate of lead, and is coloured blackish-brown by
ferric salts or by alkalis.

The alkaloids of opium cannot be detected in the petals. Attfield in
particular has examined the latter (1873) for morphine but without
obtaining a trace of that body.

[176] _Géogr. botanique_, ii (1855) 649.

[177] Flores Papaveris rubri—in the list of the pharmaceutical shop of
the town of Nördlingen. See Flückiger, in the _Archiv der Pharm._ 211
(1877) 97, No. 62.

The milky juice of the herb and capsules has a narcotic odour, and
appears to exert a distinctly sedative action. Hesse obtained from them
(1865) a colourless crystallizable substance, _Rhœadine_, C₂₁H₂₁NO₆,
of weak alkaline reaction. It is tasteless, not poisonous, nearly
insoluble in water, alcohol, ether, chloroform, benzol, or aqueous
ammonia, but dissolves in weak acids. Its solution in dilute sulphuric
or hydrochloric acid acquires after a time a splendid red colour,
destroyed by an alkali but reappearing on addition of an acid. Hesse
further believes (1877) the milky juice to contain meconic acid.

=Uses=—Red Poppy petals are employed in pharmacy only for the sake of
their fine colouring matter. They should be preferred in the fresh
state.


CAPSULÆ PAPAVERIS.

_Fructus Papaveris_; _Poppy Capsules_, _Poppy Heads_; F. _Capsules ou
Têtes de Pavot_; G. _Mohnkapseln_.

=Botanical Origin=—_Papaver somniferum_ L. Independently of the
garden-forms of this universally known annual plant, we may, following
Boissier,[178] distinguish three principal varieties, viz.:—

α. _setigerum_ (_P. setigerum_ DC), occurring in the Peloponnesus,
Cyprus, Corsica and the islands of Hières, the truly wild form of the
plant with acutely toothed leaves, the lobes sharp-pointed, and each
terminating in a bristle. The leaves, peduncles, and sepals are covered
with scattered bristly hairs, and the stigmata are 7 or 8 in number.

β. _glabrum_—Capsule subglobular, stigmata 10 to 12. Chiefly cultivated
in Asia Minor and Egypt.

γ. _album_ (_P. officinale_ Gmelin)—has the capsule more or less
egg-shaped and devoid of apertures. It is cultivated in Persia.

Besides the differences indicated above, the petals vary from white
to red or violet, with usually a dark purplish spot at the base of
each.[179] The seeds also vary from white to slate-coloured.

=History=—The poppy has been known from a remote period throughout the
eastern countries of the Mediterranean, Asia Minor, and Central Asia,
in all which regions its cultivation is of very ancient date.[180]

Syrup of poppies, a medicine still in daily use, is recommended as a
sedative in catarrh and cough in the writings of the younger Mesue
(_ob._ A.D. 1015) who studied at Bagdad, and subsequently resided at
Cairo as physician to the Caliph of Egypt. Their medicinal use seems to
have reached Europe at an early period, for the Welsh “Physicians of
Myddvai” in the 13th century already stated:[181] “Poppy heads bruised
in wine will induce a man to sleep soundly.” They even prepared pills
with the juice of poppy, which they called _opium_. In the _Ricettario
Fiorentino_ (see Appendix R) a formula is given for the syrup as
_Syroppo di Papaveri semplici di Mesue_; in the first pharmacopœia of
the London College (1618), the medicine is prescribed as _Syrupus de
Meconio Mesuæ_.

[178] _Flora Orientalis_, i. (1867) 116.

[179] English growers prefer a _white-flowered_ poppy.

[180] For further particulars consult Ritter, _Erdkunde von Asien_, vi.
(1843) 773, etc.; Unger, _Botanische Streifzüge auf dem Gebiete der
Culturgeschichte_, ii. (1857) 46.

[181] _Meddygon Myddfai_, Llandovery, 1861, 50. 216. 400.

=Description=—The fruit is formed by the union of 8 to 20 carpels, the
edges of which are turned inwards and project like partitions towards
the interior, yet without reaching the centre, so that the fruit is
really one-celled. In the unripe fruit, the sutures of the carpels are
distinctly visible externally as shallow longitudinal stripes.

The fruit is crowned with a circular disc, deeply cut into angular
ridge-like stigmas in number equal to the carpels, projecting in a
stellate manner with short obtuse lobes. Each carpel opens immediately
below the disc by a pore, out of which the seeds may be shaken; but
in some varieties of poppy the carpel presents no aperture even when
fully ripe. The fruit is globular, sometimes flattened below, or it is
ovoid; it is contracted beneath into a sort of neck immediately above
a tumid ring at its point of attachment with the stalk. Grown in rich
moist ground in England, it often attains a diameter of three inches,
which is twice that of the capsules of the opium poppy of Asia Minor or
India. While growing it is of a pale glaucous green, but at maturity
becomes yellowish-brown, often marked with black spots. The outer wall
of the pericarp is smooth and hard; the rest is of a loose texture, and
while green exudes on the slightest puncture an abundance of bitter
milky juice. The interior surface of the pericarp is rugose, and
minutely and beautifully striated transversely. From its sutures spring
thin and brittle placentæ directed towards the centre and bearing on
their perpendicular faces and edges a vast number of minute reniform
seeds.

The unripe fruit has a narcotic odour which is destroyed by drying; and
its bitter taste is but partially retained.

=Microscopic Structure=—The outer layer consists of a thin cuticle
exhibiting a large number of stomata; the epidermis is formed of a
row of small thick-walled cells. Fragments of these two layers, which
on the whole exhibit no striking peculiarity, are always found in the
residue of opium after it has been exhausted by water.

The most interesting part of the constituent tissues of the fruit
is the system of laticiferous vessels, which is of an extremely
complicated nature inasmuch as it is composed of various kinds of cells
intimately interlaced so as to form considerable bundles.[182] The
cells containing the milky juice are larger but not so much branched as
in many other plants.

[182] For particulars see _Trécul, Ann. des Sciences Nat._ v. (1866)
49; also Flückiger, _Grundlagen der Pharmaceutischen Waarenkunde_,
1873. 45.

=Chemical Composition=—The analyses of poppy heads present discrepant
results with regard to morphine. Merck and Winckler detected it in the
ripe fruit to the extent of 2 per cent., and it has also been found by
Groves (1854) and by Deschamps d’Avallon (1864). Other chemists have
been unable to find it.

In recent pharmacopœias poppy heads are directed to be taken previous
to complete maturity, and both Meurein and Aubergier have shown that
in this state they are richer in morphine than when more advanced.
Deschamps d’Avallon found them sometimes to contain narcotine. He also
obtained mucilage perceptible by neutral acetate of lead, ammonium
salts, meconic, tartaric, and citric acid, the ordinary mineral
acids, wax, and lastly two new crystalline bodies, _Papaverin_, and
_Papaverosine_. The former is not identical with Merck’s alkaloid of
the same name; although nitrogenous and bitter, it has an acid reaction
(?), yet does not combine with bases. It yields a blue precipitate with
a solution of iodine in iodide of potassium.

Papaverosine on the other hand is a base to which sulphuric acid
imparts a violet colour, changing to dark yellowish-red on addition of
nitric acid.

In ripe poppy heads, Hesse (1866) found _Rhœadine_. Groves in 1854
somewhat doubtfully announced the presence of _Codeine_. Fricker[183]
stated to have obtained from the capsules 0·10 per cent. of alkaloid,
and Krause[184] was able to prove the presence of traces of morphine,
narcotine, and meconic acid. Ripe poppy capsules (seeds removed) dried
at 100° C. afforded us 14·28 per cent. of ash, consisting chiefly
of alkaline chlorides and sulphates, with but a small quantity of
phosphate.

=Production=—Poppies are grown for medicinal uses in many parts of
England, mostly on a small scale. The large and fine fruits (poppy
heads) are usually sold entire; the smaller and less slightly are
broken and the seeds having been removed are supplied to the druggist
for pharmaceutical preparations. The directions of the pharmacopœia as
to the fruit being gathered when “nearly ripe” does not appear to be
much regarded.

=Uses=—In the form of syrup and extract, poppy heads are in common
use as a sedative. A hot decoction is often externally applied as an
anodyne.

In upper India an intoxicating liquor is prepared by heating the
capsules of the poppy with jagghery and water.[185]

[183] Dragendorff’s _Jahresbericht_, 1874. 148.

[184] _Archiv der Pharm._ 204 (1874) 507.

[185] _Catal. Ind. Departm. Internat. Exhibition._ 1862. No. 742.


OPIUM.

=Botanical Origin=—_Papaver somniferum_ L., see preceding article.

=History=[186]—The medicinal properties of the milky juice of the poppy
have been known from a remote period. Theophrastus who lived in the
beginning of the 3rd century B.C. was acquainted with the substance
in question, under the name of Μηκώνιον. The investigations of Unger
(1857; see _Capsulæ Papaveris_,) have failed to trace any acquaintance
of ancient Egypt with opium.

Scribonius Largus in his _Compositiones Medicamentorum_[187] (_circa_
A.D. 40) notices the method of procuring opium, and points out that the
true drug is derived from the capsules, and not from the foliage of the
plant.

[186] For more particulars see Dr. Rice’s learned notes in _New
Remedies_, New York, 1876, 229, reprinted in _Pharm. Journ._ vii. (2
Dec. 1876; 23 June 1877), pp. 452 and 1041.

[187] Ed. Bernhold, Argent. 1786, c. iii. sect. 22.

About the year 77 of the same century, Dioscorides[188] plainly
distinguished the juice of the capsules under the name of ὀπός from an
extract of the entire plant, μηκώνειον, which he regarded as much less
active. He described exactly how the capsules should be incised, the
performing of which operation he designated by the verb ὀπίζειν. We may
infer from these statements of Dioscorides that the collection of opium
was at that early period a branch of industry in Asia Minor. The same
authority alludes to the adulteration of the drug with the milky juices
of _Glaucium_ and _Lactuca_, and with gum.

Pliny[189] devotes some space to an account of _Opion_, of which he
describes the medicinal use. The drug is repeatedly mentioned as
_Lacrima papaveris_ by Celsus in the 1st century, and more or less
particularly by numerous later Latin authors. During the classical
period of the Roman Empire as well as in the early middle ages, the
only sort of opium known was that of Asia Minor.

The use of the drug was transmitted by the Arabs to the nations of the
East, and in the first instance to the Persians. From the Greek word
ὀπός, _juice_, was formed the Arabic word _Afyun_, which has found its
way into many Asiatic languages.[190]

The introduction of opium into India seems to have been connected with
the spread of Islamism, and may have been favoured by the Mahommedan
prohibition of wine. The earliest mention of it as a production of that
country occurs in the travels of Barbosa[191] who visited Calicut on
the Malabar coast in 1511. Among the more valuable drugs the prices
of which he quotes, opium occupies a prominent place. It was either
imported from Aden or Cambay, that from the latter place being the
cheaper, yet worth three or four times as much as camphor or benzoin.

Pyres[192] in his letter about Indian drugs to Manuel, king of
Portugal, written from Cochin in 1516, speaks of the opium of Egypt,
that of Cambay and of the kingdom of Coûs (Kus Bahár, S.W. of Bhotan)
in Bengal. He adds that it is a great article of merchandize in these
parts and fetches a good price;—that the kings and lords eat of it, and
even the common people, though not so much because it costs dear.

Garçia d’Orta[193] informs us that the opium of Cambay in the middle of
the 16th century was chiefly collected in Malwa, and that it is soft
and yellowish. That from Aden and other places near the Erythrean Sea
is black and hard. A superior kind was imported from Cairo, agreeing as
Garçia supposed with the opium of the ancient Thebaïd, a district of
Upper Egypt near the modern Karnak and Luksor.

[188] Lib. iv. c. 65.

[189] Lib. xx. c. 76.

[190] There are no ancient Chinese or Sanskrit names for opium. In the
former language the drug is called _O-fu-yung_ from the Arabic. Two
other names _Ya-pien_ and _O-pien_ are adaptations to the Chinese idiom
of our word _opium_. There are several other designations which may be
translated _Smoking dirt_, _Foreign poison_, _Black commodity_, &c.

[191] _Coasts of East Africa and Malabar_ (Hakluyt Soc.), Lond. 1866.
206, 223.

[192] _Journ. de Soc. Pharm. Lusit._ ii. (1838) 36. Pires, or Pyres,
was the first ambassador from Europe to China: Abel Rémusat, _Nouv.
mélanges asiatiques_, ii. (1829) 203. See also Pedro José da Silva,
_Elogio historico e noticia completa de Thomé Pires, pharmaceutico e
primeiro naturalista da India_, Lisboa, 1866 (Library of the Pharm.
Soc., London, Pamphlets, No. 30).

[193] _Aromatum ... Historia_, edit Clusius, Antv. 1574. lib. i. c. 4.

In India the Mogul Government uniformly sold the opium monopoly, and
the East India Company followed their example, reserving to itself the
sole right of cultivating the poppy and selling the opium.

_Opium thebaïcum_ was mentioned by Simon Januensis,[194] physician to
Pope Nicolas IV. (A.D. 1288-92), who also alludes to _meconium_ as the
dried juice of the pounded capsules and leaves. Prosper Alpinus,[195]
who visited Egypt in 1580-83, states that opium or meconium was in his
time prepared in the Thebaïd from the expressed juice of poppy heads.

The German traveller Kämpfer, who visited Persia in 1685, describes
the various kinds of opium prepared in that country. The best sorts
were flavoured with nutmeg, cardamom, cinnamon and mace, or simply
with saffron and ambergris. Such compositions were called _Theriaka_,
and were held in great estimation during the middle ages, and probably
supplied to a large extent the place of pure opium. It was not uncommon
for the sultans of Egypt of the 15th century to send presents of
_Theriaka_ to the doges of Venice and the sovereigns of Cyprus.[196]

In Europe opium seems in later times not to have been reckoned among
the more costly drugs; in the 16th century we find it quoted at the
same price as benzoin, and much cheaper than camphor, rhubarb, or
manna.[197]

With regard to China it is supposed that opium was first brought
thither by the Arabians, who are known to have traded with the southern
ports of the empire as early as the 9th century. More recently, at
least until the 18th century, the Chinese imported the drug in their
junks as a return cargo from India. At this period it was used almost
exclusively as a remedy for dysentery, and the whole quantity imported
was very small. It was not until 1767 that the importation reached
1,000 chests, at which rate it continued for some years, most of the
trade being in the hands of the Portuguese. The East India Company made
a small adventure in 1773; and seven years later an opium depôt of two
small vessels was established by the English in Lark’s Bay, south of
Macao.

The Chinese authorities began to complain of these two ships in 1793,
but the traffic still increased, and without serious interruption until
1820, when an edict was issued forbidding any vessel having opium on
board to enter the Canton river. This led to a system of contraband
trade with the connivance of the Chinese officials, which towards the
expiration of the East India Company’s charter in 1834 had assumed
a regular character. The political difficulties between England and
China that ensued shortly after this event, and the so-called Opium
War, culminated in the Treaty of Nanking (1842), by which five ports of
China were opened to foreign trade, and opium was in 1858 admitted as a
legal article of commerce.[198]

[194] _Clavis Sanationis_, Venet. 1510. 46.

[195] _De Medicina Ægyptiorum_, Lugd. Bat. 1719. 261.

[196] De Mas Latrie, _Hist. de Chypre_, iii. 406. 483; Muratori, _Rerum
Italic. Scriptores_, xxii. 1170; Amari, _I diplomi Arabi del archivio
Fiorentino_, Firenze, 1863. 358.

[197] Fontanon, _Edicts et ordonnances des roys de France_, ii. (1585)
347.

[198] For more ample particulars on these momentous events, see S.
Wells Williams’s _Middle Kingdom_, vol. ii. (1848); _British Almanac
Companion_ for 1844, p. 77.

The vice of opium-smoking began to prevail in China in the second half
of the 17th century,[199] and in another hundred years had spread like
a plague over the gigantic empire. The first edict against the practice
was issued in 1796, since which there have been innumerable enactments
and memorials,[200] but all powerless to arrest the evil which is still
increasing in an alarming ratio. Mr. Hughes, Commissioner of Customs at
Amoy, thus wrote on this subject in his official _Trade Report_[201]
for the year 1870:—“Opium-smoking appears here as elsewhere in China
to be becoming yearly a more recognized habit,—almost a necessity of
the people. Those who use the drug now do so openly, and native public
opinion attaches no odium to its use, so long as it is not carried to
excess.... In the city of Amoy, and in adjacent cities and towns, the
proportion of opium-smokers is estimated to be from 15 to 20 per cent.
of the adult population.... In the country the proportion is stated to
be from 5 to 10 per cent....”

=Production=—The poppy in whatever region it may grow always contains a
milky juice possessing the same properties; and the collection of opium
is _possible_ in all temperate and subtropical countries where the
rainfall is not excessive. But the production of the drug is limited by
other conditions than soil and climate, among which the value of land
and labour stands pre-eminent.

At the present day opium is produced on an important scale in Asia
Minor, Persia, India, and China; to a small extent in Egypt. The drug
has also been collected in Europe, Algeria,[202] North America,[203]
and Australia[204] but more for the sake of experiment than as an
object of commerce.

We shall describe the production of the different kinds under their
several names.

1. _Opium of Asia Minor_; _Turkey, Smyrna, or Constantinople
Opium_[205]—The poppy from which this most important kind of opium
is obtained is _Papaver somniferum_, var. β. _glabrum_ Boissier. The
flowers are commonly purplish, but sometimes white, and the seeds vary
from white to dark violet.

The cultivation is carried on throughout Asia Minor, both on the
more elevated and the lower lands, the cultivators being mostly
small peasant proprietors. The plant requires a naturally rich and
moist soil, further improved by manure, not to mention much care and
attention on the part of the grower. Spring frosts, drought, or locusts
sometimes effect its complete destruction. The sowing takes place at
intervals from November to March, partly to insure against risk of
total failure, and partly in order that the plants may not all come to
perfection at the same time.

[199] Bretschneider, _Study of Chinese Bot. Works_, 1870. 48.

[200] _Chinese Repository_, vol. v. (1837) vi &c.

[201] Addressed to the Inspector-General of Customs, Pekin, and
published at Shanghai, 1871

[202] _Pharm. Journ._ xv. (1856) 348.

[203] _Am. Journ. of Phar._ xviii. (1870) 124; _Journ. of Soc. of
Arts_, Dec. 1, 1871.

[204] _Pharm. Journ._ Oct. 1, 1870. 272.

[205] Much information under this head has been derived from a paper
_On the production of Opium in Asia Minor_ by S. H. Maltass (_Pharm.
Journ._ xiv. 1855. 396), and one _On the Culture and Commerce in Opium
in Asia Minor_, by E. R. Heffler, of Smyrna (_Pharm. Journ._ x. 1869.
434).

The plants flower between May and July according to the elevation
of the land. A few days after the fall of the petals the poppy head
being about an inch and a half in diameter is ready for incision. The
incision is made with a knife transversely, about half-way up the
capsule, and extends over about two-thirds the circumference, or is
carried spirally to beyond its starting point. Great nicety is required
not to cut too deep so as to penetrate the capsule, as in that case
some of the juice would flow inside and be lost. The incisions are
generally made in the afternoon and the next morning are found covered
with exuded juice. This is scraped off with a knife, the gatherer
transferring it to a poppy leaf which he holds in his left hand. At
every alternate scraping, the knife is wetted with saliva by drawing
it through the mouth, the object being to prevent the adhesion of the
juice to the blade. Each poppy-head is, as a rule, cut only once; but
as a plant produces several heads all of which are not of proper age at
the same time, the operation of incising and gathering has to be gone
over two or three times on the same plot of ground.

As soon as a sufficient quantity of the half-dried juice has been
collected to form a cake or lump, it is wrapped in poppy leaves and put
for a short time to dry in the shade. There is no given size for cakes
of opium, and they vary in weight from a few ounces to more than two
pounds. In some villages it is the practice to make the masses larger
than in others. Before the opium is ready for the market, a meeting of
buyers and sellers is held in each district, at which the price to be
asked is discussed and settled,—the peasants being most of them in debt
to the buyers or merchants.

To the latter the opium is sold in a very soft but natural state. These
dealers sometimes manipulate the soft drug with a wooden pestle into
larger masses which they envelope in poppy leaves and pack in cotton
bags sealed at the mouth for transport to Smyrna. According to another
account, the opium as obtained from the grower is at once packed in
bags together with a quantity of the little chaffy fruits of a dock
(_Rumex_ sp.) to prevent the lumps from sticking together, and so
brought in baskets to Smyrna, or ports farther north.

The opium remains in the baskets (placed in cool warehouses to avoid
loss of weight) till sold, and it is only on reaching the buyer’s
warehouse that the seals are broken and the contents of the bags
exposed. This is done in the presence of the buyer, seller, and
a public examiner, the last of whom goes through the process of
inspecting the drug piece by piece, throwing aside any of suspicions
quality. Heffler of Smyrna asserts that the drug is divided into three
qualities, viz.—the _prime_, which is not so much a selected quality
as the opium of some esteemed districts,—the _current_, which is the
mercantile quality and constitutes the great bulk of the crop,—and
lastly the inferior or _chiqinti_.[206] The opium of very bad quality
or wholly spurious he would place in a fourth category. Maltass applies
the name _chiqinti_ (or _chicantee_) to opium of every degree of
badness.

The examination of opium by the official expert is not conducted in any
scientific method. His opinion of the drug is based on colour, odour,
appearance and weight, and appears to be generally very correct. Fayk
Bey (1867) has recommended the Turkish government to adopt the more
certain method of assaying opium by chemical means.

[206] Probably signifying _refuse_,—_that which comes out_.

In Asia Minor the largest quantities of opium are now produced in the
north-western districts of Karahissar Sahib, Balahissar, Kutaya, and
Kiwa (or Geiveh), the last on the river Sakariyeh which runs into the
Black Sea. These centres of large production of opium send a superior
quality of the drug to Constantinople by way of Izmid; the best
apparently from Bogaditch and Balikesri, near the Susurlu river. Angora
and Amasia are other places in the north of Asia Minor whence opium is
obtained.

In the centre of the peninsula Afium Karahissar (literally
_opium-black-castle_) and Ushak are important localities for opium,
which is also the case with Isbarta, Buldur and Hamid farther south.
The product of these districts finds its way to Smyrna, in the
immediate neighbourhood of which but little opium is produced. The
export from Smyrna in 1871, in which year the crop was very large, was
5650 cases, valued at £784,500.[207]

_Turkey Opium_, as it is generally called in English trade, occurs in
the form of rounded masses which according to their softness become
more or less flattened or many-sided, or irregular by mutual pressure
in the cases in which they are packed. There appears to be no rule as
to their weight[208] which varies from an ounce up to more than 6 lb.;
from ½ lb. to 2 lb. is however the most usual. The exterior is covered
with the remains of poppy leaves strewn over with the _Rumex_ chaff
before alluded to, which together make the lumps sufficiently dry to be
easily handled. The consistence is such that the drug can be readily
cut with a knife, or moulded between the fingers. The interior is moist
and coarsely granular, varying in tint from a light chestnut to a
blackish brown. Fine shreds of the epidermis of the poppy capsule are
perceptible even to the naked eye, but are still more evident if the
residue of opium washed with water, is moistened with dilute chromic
acid (1 to 100). The odour of Turkey opium is peculiar, and though
commonly described as narcotic and unpleasant, is to many persons far
from disagreeable. The taste is bitter.

The substances alleged to be used for adulterating Turkey opium are
sand, pounded poppy capsules, pulp of apricots or figs, gum tragacanth
or even turpentine. Bits of lead are sometimes found in the lumps, also
stones and masses of clay.

2. _Egyptian Opium_,—though not abundant little as formerly is still
met with in European commerce. It usually occurs in hard, flattish
cakes about 4 inches in diameter covered with the remnants of a
poppy leaf, but not strewn over with rumex-fruits. We have also seen
it (1873) as freshly imported, in a soft and plastic state. The
fractured surface of this opium (when hard) is finely porous, of a dark
liver-colour, shining here and there from imbedded particles of quartz
or gum, and reddish-yellow points (of resin?). Under the microscope an
abundance of starch granules is sometimes visible. The morphine in a
sample from Merck amounted to 6 per cent.

[207] Consul Cumberbatch, _Trade Report for 1871_, presented to
Parliament.

[208] The largest lump I have seen weighed 6 lb. 6 oz., being part of
65 packages which I examined 2nd July, 1873.—D. H.

According to Von Kremer who wrote in 1863,[209] there were then in
Upper Egypt near Esneh, Kenneh, and Siout, as much as 10,000 _feddan_
(equal to about the same number of English acres) of land cultivated
with the poppy from which opium was obtained in March, and seed
in April. Hartmann[210] states that the cultivation is carried on
by the government, and solely for the requirement of the sanitary
establishments.

S. Stafford Allen in 1861 witnessed the collection of opium at Kenneh
in Upper Egypt,[211] from a white-flowered poppy. An incision is made
in the capsule by running a knife twice round it transversely, and the
juice scraped off the following day with a sort of scoop-knife. The
gatherings are collected on a leaf and placed in the sun to harden. The
produce appeared extremely small and was said to be wholly used in the
country.

Gastinel, director of the Experimental Garden at Cairo, and government
inspector of pharmaceutical stores, has shown (1865) that the poppy in
Egypt might yield a very good product containing 10 to 12 per cent. of
morphine, and that the present bad quality of Egyptian opium is due
to an over-moist soil, and a too early scarification of the capsule,
whereby (not to mention wilful adulteration) the proportion of morphine
is reduced to 3 or 4 per cent.

In 1872, 9636 lb. of opium, value £5023, were imported into the United
Kingdom from Egypt.

3. _Persian Opium_.—Persia, probably the original home of the baneful
practice of opium-eating, cultivates the drug chiefly in the central
provinces where, according to Boissier, the plant grown to furnish it
is _Papaver somniferum_, var. γ _album_ (_P. officinale_ Gm.) having
ovate roundish capsules. Poppy heads from Persia which we saw at the
Paris Exhibition in 1867, had vertical incisions and contained white
seeds.

The strongest opium called in Persia _Teriak-e-Arabistani_ is obtained
in the neighbourhood of Dizful and Shuster, east of the Lower Tigris.
Good opium is likewise produced about Sari and Balfarush in the
province of Mazanderan, and in the southern province of Kerman. The
lowest quality which is mixed with starch and other matters, is sold
in light brown sticks; it is made at Shahabdulazim, Kashan, and
Kum.[212] A large quantity of opium appears to be produced in Khokan
and Turkestan.

[209] _Aegypten, Forschungen über Land und Volk während eines 10
zehnjährigen Aufenthalts_, Leipzig, 1863.

[210] _Naturgeschichtl. medicin. Skizze der Nilländer_, Berlin, 1866.
353.

[211] _Pharm. Journ._ iv. (1863) 199.

[212] Polak, _Persien_, ii. (1865) 248, &c.

Persian opium is carried overland to China through Bokhara, Khokan and
Kashgar;[213] but since 1864 it has also been extensively conveyed
thither by sea, and it is now quoted in trade reports like that of
Malwa, Patna, and Benares.[214] It is exported by way of Trebizond to
Constantinople where it used to be worked up to imitate the opium of
Asia Minor, and at the same time adulterated.[215] Since 1870, Persian
opium which was previously rarely seen as such in Europe, has been
imported in considerable quantity, being shipped now from Bushire
and Bunder Abbas, in the Persian Gulf, to London or to the Straits
Settlements and China. It occurs in various forms, the most typical
being a short rounded cone weighing 6 to 10 ounces. We have also seen
it in flat circular cakes, 1¼ lb. in weight. In both forms the drug
was of firm consistence, a good opium-smell, and internally brown of a
comparatively light tint. The surface was strewn over with remnants of
stalks and leaves. Some of it had been collected with the use of oil
as in Malwa (see p. 51), which was apparent from the greasiness of the
cone, and the globules of oil visible when the drug was cut. The best
samples of this drug as recently imported, have yielded 8 to 10·75 per
cent. of morphine, reckoned on the opium in its moist state.[216]

[213] Powell, _Economic Products of the Punjab_, i. (1868) 294.

[214] Thus in the _Trade Report_ for Foochow, for 1870, addressed to
Mr. Hart, Inspector-General of Customs, Pekin, is the following table:

Malwa. Patna. Benares. Persian. Imports of Opium in 1867 chests 2327
1673 724 300 ” ” 1868 ” 2460 1257 377 544 ” ” 1869 ” 2201 1340 410 493
” ” 1870 ” 1849 1283 245 630


[215] Letter from Mr. Merck to Dr. F. 1863.

[216] Information kindly given us (9th June, 1873) by Mr. W. Dillworth
Howard, of the firm of Howard and Sons, Stratford. A morphine
manufacturer has no particular interest in ascertaining the amount
of water in the opium he purchases. All he requires to know is the
percentage of morphine which the drug contains. It is otherwise with
the pharmaceutist, whose preparations have to be made with _dried
opium_.

Carles,[217] from a specimen which seems to have been adulterated with
sugar, obtained 8·40 per cent. of morphine, and 3·60 of narcotine, the
drug not having been previously dried.

Inferior qualities of Persian opium have also been imported. Some
that was soft black and extractiform afforded _undried_ only 3 to ½
per cent. of morphine (Howard); while some of very pale hue in small
sticks, each wrapped in paper, yielded no more than 0·2 per cent.!
(Howard). For further details, see p. 61.

In Turkestan an aqueous extract of poppy heads collected before
maturity is prepared; it seems to be rich in alkaloids.[218]

4. _European Opium_—From numerous experiments made during the present
century in Greece, Italy, France, Switzerland, Germany, England, and
even in Sweden, it has been shown that in all these countries a very
rich opium, not inferior to that of the East, can be produced.

The most numerous attempts at opium-growing in Europe have been
made in France. But although the cultivation was recommended in the
strongest terms by Guibourt,[219] who found in French opium the highest
percentage of morphine yet observed (22·8 per cent.), it has never
become a serious branch of industry.

Aubergier of Clermont-Ferrand has carried on the cultivation with great
perseverance since 1844, and has succeeded in producing a very pure
inspissated juice which he calls _Affium_, and which is said to contain
uniformly[220] 10 per cent. of morphine. It is made up in cakes of 50
grammes, but is scarcely an article of wholesale commerce.[221]

Some careful and interesting scientific investigations relating to
the production of opium in the neighbourhood of Amiens, were made by
Decharme in 1855 to 1862.[222] He found 14,725 capsules incised within
6 days to afford 431 grammes of milky juice, yielding 205 grammes (=
47·6 per cent.) of dry opium containing 16 per cent. of morphine.
Another sample of dried opium afforded 20 per cent. of morphine.
Decharme observed that the amount of morphine diminished when the juice
is very slowly dried,—a point of great importance deserving attention
in India. The peculiar odour of opium as observable in the oriental
drug, is developed, according to the same authority, by a kind of
fermentation.[223] Adrian even suggests that morphine is formed only by
a similar process, inasmuch as he could obtain none by exhausting fresh
poppy capsules with acidulated alcohol, while capsules of the same crop
yielded an opium rich in morphine.

[217] _Journ. de Pharm._ xvii (1873) 427.

[218] Fedschenko’s Catalogue of the Moscow Exhibition, Turkestan
department, in Buchner’s _Repertorium für Pharmacie_, xxii. (1873) 221.

[219] _Journ. de Pharm._ xli. (1862) 184, 201.

[220] How this uniformity is insured we know not.

[221] Dorvault, _Officine_, éd. 8. 1872. 648.

[222] They are recorded in several pamphlets, for which we are indebted
to the author, reprinted from the _Mém. de l’Acad. du déartement de la
Somme_ and the _Mém. de l’Académie Stanislas_.

[223] _Journ. de Pharm._ vi. (1867) 222.

5. _=East Indian Opium=_—The principal region of British India
distinguished for the production of opium is the central tract of
the Ganges, comprising an area of about 600 miles in length, by 200
miles in width. It reaches from Dinajpur in the east, to Hazaribagh in
the south, and Gorakhpur in the north, and extends westward to Agra,
thus including the flat and thickly-populated districts of Behar and
Benares. The amount of land here actually under poppy cultivation was
estimated in 1871-72 as 560,000 acres.

The region second in importance for the culture of opium consists of
the broad table-lands of Malwa, and the slopes of the Vindhya Hills, in
the dominions of the Holkar.

Beyond these vast districts, the area under poppy cultivation is
comparatively small,[224] yet it appears to be on the increase.
Stewart[225] reports (1869) that the plant is grown (principally for
opium) throughout the plains of the Punjab, but less commonly in the
north-west. In the valley of the Biās, east of Lahore, it is cultivated
up to nearly 7500 feet above the sea-level.

The manufacture of opium in these parts of India is not under any
restriction as in Hindustan. Most districts, says Powell (1868),[226]
cultivate the poppy to a certain extent, and produce a small quantity
of indifferent opium for local consumption. The drug, however, is
prepared in the Hill States, and the opium of Kūlū (E. of Lahore),
is of excellent quality, and forms a staple article of trade in that
region. Opium is also produced in Nepal, Basāhīr and Rāmpūr, and at
Doda Kashtwar in the Jammū territory.[227] It is exported from these
districts to Yarkand, Khutan, Aksu, and other Chinese provinces,—to the
extent in 1862 of 210 _maunds_ (= 16,800 lb.). The Madras Presidency
exports no opium at all.

The opium districts of Bengal[228] are divided into two agencies,
those of Behar and Benares, which are under the control of officials
residing respectively at Patna and Ghazipur. The opium is a government
monopoly—that is to say, the cultivators are under an obligation to
sell their produce to the government at a price agreed on beforehand;
at the same time it is wholly optional with them, whether to enter on
the cultivation or not.

[224] So we may infer from the fact that of the 39,225 chests which
paid duty to Government at Bombay in 1872, 37,979 were Malwa opium, the
remaining 1,246 being reckoned as from Guzerat.—_Statement of the Trade
and Nav. of Bombay for 1871-72_, p. xv.

[225] _Punjab Plants_, Lahore, 1869. 10.

[226] _Op. cit._ i. 294.

[227] At the base of the Himalaya, S. and S.E. of Kashmir.

[228] Much of what follows respecting Bengal opium is derived from a
paper by Eatwell, formerly First Assistant and Opium Examiner in the
Government Factory at Ghazipur.—_Pharm. Journ._ xi. (1852) 269, &c.

The variety of poppy cultivated is the same as in Persia, namely, _P.
somniferum_, var. γ _album_. As in Asia Minor, a moist and fertile
soil is indispensable.[229] The plant is liable to injury by insects,
excessive rain, hail, or the growth on its roots of a species of
_Orobanche_.

In Behar the sowing takes place at the beginning of November, and the
capsules are sacrificed in February or March (March or April in Malwa).
This operation is performed with a peculiar instrument, called a
_nushtur_, having three or four two-pointed blades, bound together with
cotton thread.[230] In using the _nushtur_, only one set of points is
brought into use at a time, the capsule being scarified vertically from
base to summit. This scarification is repeated on different sides of
the capsule at intervals of a few days, from two to six times. In many
districts of Bengal, transverse cuts are made in the poppy-head as in
Asia Minor.

The milky juice is scraped off early on the following morning with
an iron scoop, which as it becomes filled is emptied into an earthen
pot carried by the collector’s side. In Malwa a flat scraper is used
which, as well as the fingers of the gatherer, is wetted from time to
time with linseed oil to prevent the adhesion of the glutinous juice.
All accounts represent the juice to be in a very moist state by reason
of dew, which sometimes even washes it away; but so little is this
moisture of the juice thought detrimental that, as Butter states,[231]
the collectors in some places actually wash their scrapers in water,
and add the washings to the collection of the morning!

The juice when brought home is a wet granular mass of pinkish colour;
and in the bottom of the vessel in which it is contained, there
collects a dark fluid resembling infusion of coffee, which is called
_pasēwā_. The recent juice strongly reddens litmus, and blackens
metallic iron. It is placed in a shallow earthen vessel, which is
tilted in such a manner that the _pasēwā_ may drain off as long as
there is any of it to be separated. This liquor is set aside in a
covered vessel. The residual mass is now exposed to the air, though
never to the sun, and turned over every few days to promote its
attaining the proper degree of dryness, which according to the Benares
regulations, allows of 30 per cent. of moisture. This drying operation
occupies three or four weeks.

The drug is then taken to the Government factory for sale; previous to
being sold it is examined for adulteration by a native expert, and its
proportion of water is also carefully determined. Having been received
into stock, it undergoes but little treatment beyond a thorough mixing,
until it is required to be formed into globular cakes. This is effected
in a somewhat complicated manner, the opium being strictly of standard
consistence. First the quantity of opium is weighed out, and having
been formed into a ball is enveloped in a crust of dried poppy petals,
skilfully agglutinated one over the other by means of a liquid called
_lēwā_. This consists partly of good opium, partly of _pasēwā_, and
partly of opium of inferior quality, all being mixed with the washings
of the various pots and vessels which have contained opium, and then
evaporated to a thick fluid, 100 grains of which should afford 53 of
dry residue. These various things are used to form a ball of opium in
the following proportions:—

[229] It is said (1873) that the ground devoted to poppy-culture in
Bengal is becoming impoverished, and that the plant no longer attains
its usual dimensions.

[230] For figures of the instrument, see _Pharm. Journ._ xi. (1862) 207.

[231] _Pharm. Journ._ xi. (1852) 209.

                                   seers.  chittaks.
    Opium of standard consistence    1      7·50
      ”   contained in _lēwā_          3·75
    Poppy petals                            5·43
    Fine _trash_                            0·50
                                     -----------
                                     2      1·18 = about 4 lb. 3½ oz.
                                                         avoirdupois.
                                     -----------

The finished balls usually termed _cakes_, which are quite spherical
and have a diameter of 6 inches, are rolled in _poppy trash_ which is
the name given to the coarsely powdered stalks, capsules and leaves
of the plant; they are then placed in small dishes and exposed to the
direct influence of the sun. Should any become distended, it is at
once opened, the gas allowed to escape, and the cake made up again.
After three days the cakes are placed, by the end of July, in frames in
the factory where the air is allowed to circulate. They still however
require constant watching and turning, as they are liable to contract
mildew which has to be removed by rubbing in _poppy trash_. By October
the cakes have become perfectly dry externally and quite hard, and are
in condition to be packed in cases (40 cakes in each) for the China
market which consumes the great bulk of the manufacture.

For consumption in India the drug is prepared in a different shape.
It is inspissated by solar heat till it contains only 10 per cent. of
moisture, in which state it is formed into square cages of 2 lb. each
which are wrapped in oil paper, or it is made into flat square tablets.
Such a drug is known as _Abkāri Opium_.

The Government opium factories in Bengal are conducted on the most
orderly system. The care bestowed in selecting the drug, and in
excluding any that is damaged or adulterated is such that the merchants
who purchase the commodity rarely require to examine it, although
permission is freely accorded to open at each sale any number of chests
or cakes they may desire. In the year 1871-72 the number of chests sold
was 49,695, the price being £139 per chest, which is £26 higher than
the average of the preceding year. The net profit on each chest was
£90.[232]

In Malwa the manufacture of opium is left entirely to private
enterprise, the profit to Government being derived from an export duty
of 600 rupees (£60) per chest.[233] As may readily be supposed, the
drug is of much less uniform quality than that which has passed through
the Bengal agencies, and having no guarantee as to purity it commands
less confidence.

[232] _Statement exhibiting the moral and material progress and
condition of India during the year_ 1871-72,—Blue Book ordered to be
printed 29th July, 1873. p. 10.

[233] The revenue by this duty upon opium exported from Bombay in the
year 1871-72, was £2,353,500.

Malwa opium is not made into balls, but into rectangular masses, or
bricks which are not cased in poppy petals; it contains as much as 95
per cent. of dry opium. Some opium sold in London as _Malwa Opium_ in
1870 had the form of rounded masses covered with vegetable remains. It
was of firm consistence, dark colour, and rather smoky odour. W. D.
Howard obtained from it (_undried_) 9 per cent. of morphine. Other
importations afforded the same chemist 4·8 and 6 per cent. respectively.

The chests of Patna opium hold 120 catties or 160 lb. Those of Malwa
opium 1 pecul or 133⅓ lb.

The quantity of opium produced in India cannot be ascertained, but the
amount exported[234] is accurately known. Thus from British India the
exports in the year ending March 31, 1872, were 93,364 chests valued at
£13,365,228. Of this quantity Bengal furnished 49,455 chests, Bombay
43,909 chests: they were exported thus:—

    To China                                    85,470 chests.
      The Straits Settlements                    7,845   ”
      Ceylon, Java, Mauritius and Bourbon           38   ”
      The United Kingdom                             4   ”
      Other countries                                7   ”
                                                ------
                              Total             93,364   ”
                                                ------

The net revenue to the Government of India from opium in the year
1871-72 was £7,657,213.

6. _=Chinese Opium=_—China consumes not only nine-tenths of the opium
exported from India, and a considerable quantity of that produced in
Asia Minor, but the whole of what is raised in her own provinces. How
large is this last quantity we shall endeavour to show.

The drug is mentioned as a production of Yunnan in a history of that
province, of which the latest edition appeared in 1736. But it is only
very recently that its cultivation in China has assumed such large
proportions as to threaten serious competition with that in India.[235]

In a _Report upon the Trade of Hankow_ for 1869, addressed to Mr.
Hart, Inspector-General of Customs, Pekin, we find _Notes of a journey
through the opium districts of Szechuen_, undertaken for the special
purpose of obtaining information about the drug.[236] From these notes
it appears that the estimated crop of the province for 1869 was 4235
peculs (= 564,666 lb.). This was considered _small_, and the Szechuen
opium merchants asserted that 6000 peculs was a fair average. The same
authorities estimated the annual yield of the province of Kweichow
at 15,000, and of Yunnan at 20,000 peculs, making a total of 41,000
peculs or 5,466,666 lb. In 1869 also, Sir R. Alcock reported that about
two-thirds of the province of Szechuen and one-third of that of Yunnan
were devoted to opium.[237]

Mr. Consul Markham states[238] that the province of Shensi likewise
furnishes important supplies. Mr. Edkins the well-known missionary
has lately pointed out from personal observation[238] the extensive
cultivation of the poppy in the north-eastern province of Shantung.

[234] _Annual Statement of the Trade and Navigation of British India
with foreign countries_, published by order of the Governor-General,
Calcutta, 1872. 52.

[235] In the _Report on the Trade of Hankow for 1869_ addressed to
Mr. Hart, Inspector-General of Customs, Pekin, it is stated—“The
importation of opium is considerably short for the last two seasons,
but this is not to be wondered at now that each opium-shopkeeper in
this and the surrounding districts advertises native drug for sale.”

W. H. Medhurst, British Consul at Shanghai, says—“The drug is now being
so extensively produced by the Chinese upon their own soil as sensibly
to affect the demand for the India-grown commodity.”—_Foreigner in Far
Cathay_, Lond. 1872. 20.

The quantity of opium exported from Bombay in 1871-72 was less by 1719
chests than that exported in 1870-71, the decrease being attributed to
the present large cultivation in China.—_Statement of the Trade and
Nav. of Bombay for 1871-72_, pp. xii. xvi.

[236] According to the French missionaries, the cultivation of the
poppy in the great province of Szechuen was hardly known even so
recently as 1840.

[237] _Calcutta Blue Book_, p. 205.

[238] _Journ. of Soc. of Arts_, Sept. (1872) 6, p. 338.

Opium of very fair quality is now produced about Ninguta (lat. 44°) in
north-eastern Manchuria, a region having a rigorous winter climate.
Consul Adkins of Newchwang who visited this district in 1871, reports
that the opium is inspissated in the sun until hard enough to be
wrapped in poppy leaves, and that its price on the spot is equal to
about 1s. per ounce.[239]

Shensi opium is said to be the best, then that of Yunnan. But Chinese
consumers mostly regard home-grown opium as inferior in strength and
flavour, and only fit for use when mixed with the Indian drug.[240]

It must not be supposed that the growing of opium in China has passed
unnoticed by the Chinese Government. Whatever may be the nature of the
sanction now accorded to this branch of industry, it was “rigorously”
prohibited, at least in some provinces, about ten years ago, the
effect of the prohibition being to stimulate the foreign importations.
Thus at Shanghai in 1865, the importation of Benares opium was 2637
peculs,[241] being more than double that of the previous year, and
Persian opium, very rarely seen before, was imported to the extent of
533 peculs, besides about 70 peculs of Turkish.[242]

Of the growth of the trade in opium between India and China, the
following figures[243] will give some idea: value of exports in

    1852-53—£6,470,915.   1861-62—£9,704,972.   1871-72—£11,605,577.

and[244]

  In               1872        1873        1874        1875       1876
  Chests opium,   93,364      82,908      88,727      94,746      88,350
  Value,     £13,365,228  11,426,280  11,341,857  11,956,972  11,148,426

In 1877 the imports of opium in Hong Kong were stated to consist
of 6818 peculs, valued at 2,380,665 taels, coming from Patna (2158
peculs), Benares (3596 peculs), Persia (1041 peculs), Malwa (10
peculs), Turkey (3⅓ peculs). In the same year 4043 peculs of opium were
imported in Amoy.

Poppy cultivation in the south-west of China has been briefly described
by Thorel,[245] from whose remarks it would appear to be exactly like
that of India. The poppy is white-flowered; the head is wounded with a
three-bladed knife, in a series of 3 to 5 vertical incisions, and the
exuded juice is scraped off and transferred to a small pot suspended at
the waist. How the drug is finished off we know not. A Chinese account
states simply that the best opium is sun-dried. But little is known of
its physical and chemical properties. Thorel speaks of it as a soft
substance resembling an extract. Dr. R. A. Jamieson[246] describes
a sample submitted to him as a flat cake enveloped in the sheathing
petiole of bamboo; externally it was a blackish-brown, glutinous
substance, dry and brittle on the outside. It lost by drying 18 per
cent. of water, and afforded upon incineration 7·5 per cent. of ash. In
100 grains of the (undried) drug, there were found 5·9 of morphine, and
7·5 of narcotine. (See also p. 62.)

[239] _North China Herald_, June 28, 1873.

[240] _Reports of H.M. Consuls in China_, 1871 (No. 3, 1872), 1874 (No.
5, 1875), p. 4, 23.

[241] One pecul = 133⅓ lb.

[242] _Reports on the Trade at the Treaty Ports in China for 1865._ 125.

[243] Taken from the _Annual Statement of the Trade and Navigation
of British India with foreign countries_, published by order of the
Governor-General, Calcutta, 1872—199.

[244] _Statistical Abstract relating to British India_ from 1866-67 to
1875-76. London, 1877, pp. 51, 53.

[245] _Notes médicales du voyage d’exploration du Mékong et de
Cochinchine_, Paris, 1870. 23.

[246] _Report on the Trade of Hankow_, before quoted.

The Chinese who prepare opium for use by converting it into an aqueous
extract which they smoke, do not estimate the value of the drug
according to its richness in morphine, but by peculiarities of aroma
and degree of solubility. In China the preparation of opium for smoking
is a special business, not beneath the notice even of Europeans.[247]

7. _=Zambezi=_ or _=Mozambik Opium=_—From a notice in Pharm. Journal
viii. (1878) 1007, it would appear that the Portuguese have formed
in 1877 a large company called the “Mozambique Opium Cultivating and
Trading Company.”

=Description=—The leading characteristics of each kind of opium have
been already noticed. The following remarks bear chiefly on the
microscopic appearances of the drug.

As will be presently shown, a more or less considerable part of the
drug consists of peculiar substances which are mostly crystallizable
and are many of them present in a crystalline state in the drug itself.
All kinds of opium appear more or less crystalline when a little in a
dry state is triturated with benzol and examined under the microscope.
The forms are various: opium from Asia Minor exhibits needles and
short imperfect crystals usually not in large quantity, whereas
Indian and still more Persian opium is not only highly crystalline
but shows a variety of forms which become beautifully evident when
seen by polarized light. In several kinds large crystals occur which
are doubtless sugar, either intentionally mixed or naturally present.
The crystals seen in opium are not however sufficiently developed
to warrant positive conclusions as to their nature, besides which
the opium constituents when pure are capable under slightly varied
circumstances of assuming very different forms. Hence the attempt to
obtain from solutions crystals which shall be comparable with those of
the same substances in a state of purity often fails. Some interesting
observations in this direction were made by Deane and Brady in
1864-5.[248]

All opium has a peculiar narcotic odour and a sharp bitter taste.

=Chemical Composition=—Poppy-juice like analogous vegetable fluids is a
mixture of several substances in variable proportion. With the commoner
substances which constitute the great bulk of the drug we are not yet
sufficiently acquainted.

[247] In 1870, a British firm at Amoy opened an establishment for
preparing opium for the supply of the Chinese in California and
Australia—_Pall Mall Gazette_, Nov. 7th, 1878, p. 7, announces:
“The monopoly of preparing and selling opium in the 14 districts of
Kwang-chow-fu, has been leased to a Hong at Canton for 3 years, ...
innovation on former practice.... Opium shops are henceforth to be
licensed, and the Exchequer will receive the yearly sum of 140,000
dollars—a welcome addition to the revenue.”

[248] _Pharm. Journ._ vi. 234; vii. 183. with 4 beautiful plates
representing the crystallizations from extract and tincture of opium as
well as from the pure opium constituents. When the juice of the poppy
is prevented from rapid drying by the addition of a little glycerin,
crystals are developed in it.

In the first place (independently of water) there is found mucilage
distinct from that of gum arabic, also pectic matter,[249] and albumin.
These bodies, together with unavoidable fragments of the poppy
capsules, probably amount on an average to more than half the weight of
the opium.[250]

In addition to these substances, the juice also contains sugar in
solution,—in French opium to the extent of 6½ to 8 per cent.: according
to Decharme it is uncrystallizable. Sugar also exists in other opium,
but whether always naturally has not been determined.

Fresh poppy-juice contains in the form of emulsion, wax, pectin,
albumin and insoluble calcareous salts. When good Turkey opium is
treated with water these substances remain in the residue to the extent
of 6 to 10 per cent.

Hesse (1870) has isolated the _wax_ by exhausting the refuse of opium
with boiling alcohol and a little lime. He thus obtained a crystalline
mass from which he separated by chloroform _Palmitate_ and _Cerotate of
Cerotyl_, the former in the larger proportion.

The presence of _Caoutchouc_ has also been pointed out; Procter[251]
found opium produced in Vermont to contain about 11 per cent. of that
substance, together with a little fatty matter and resin.

Respecting the colouring matter and an extremely small quantity of a
volatile body with pepper-like odour, we know but little. After the
colouring matter has been precipitated from an aqueous solution of
opium by lead acetate, the liquid becomes again coloured by exposure
to the air. As to the volatile body, it may be removed by acetone or
benzol, but has not yet been isolated.

The salts of inorganic bases, chiefly of calcium, magnesium and
potassium, contain partly the ordinary acids such as phosphoric and
sulphuric, and partly an acid peculiar to the poppy.

Good opium of Asia Minor dried at 100° C. yields 4 to 8 per cent. of
ash.

Poppy-juice contains neither starch nor tannic acid, the absence of
which easily detected substances affords one criterion for judging of
the purity of the drug.

The proportion of water in opium is very variable. In drying Turkey
opium previous to pulverization and for other pharmaceutical purposes,
the average loss is about 12½ per cent.[252] Bengal opium, which
resembles a soft black extract, is manufactured so as to contain 30 per
cent. of water.

[249] We had the opportunity of examining very good specimens of pectic
matter and caoutchouc from opium, with which we were presented (1879)
by Messrs. J. F. Macfarlane & Co., of London and Edinburgh.

[250] Flückiger, in _Pharm. Journ._ x. (1869) 208.

[251] _American Journ. of Pharm._, 1870. 124.

[252] From the laboratory accounts of Messrs. Allen and Hanburys,
London, by which it appears that 200 lb. of Turkey opium dried at
various times in the course of 10 years lost in weight 25¼ lb.

As the active constituents of opium, or at all events the morphine, can
be completely extracted by cold water, the proportion of soluble matter
is of practical importance. In good opium of Asia Minor previously
dried, the extract (dried at 100° C.) always amounts to between 55
and 66 per cent.,—generally to more than 60, thus affording in many
instances a test of the pureness of the drug. Dried Indian opium yields
from 60 to 68 per cent. of matter soluble in cold water.[253]

The peculiar constituents of opium are of basic, acid, or neutral
nature. Some of these substances were observed in opium as early as
the 17th and 18th century, and designated _Magisterium Opii_. Bucholz
in 1802 vainly endeavoured to obtain a salt from the extract by
crystallization. In 1803, however, Charles Derosne, an apothecary of
Paris, in diluting a syrupy aqueous extract of opium, observed crystals
of the substance now called _Narcotine_, which he prepared pure. He
believed that the same body was obtained by precipitating the mother
liquor with an alkali, but what he so got was morphine. It is needless
to pursue the further researches of Derosne. Ingenious as they were,
it was reserved for Friedrich Wilhelm Adam Sertürner, apothecary of
Einbeck in Hanover (_nat. 1783_, _ob. 1841_) to discover their true
interpretation.

Sertürner had been engaged since 1805 with the chemical investigation
of opium, and in 1816 he summarized his results in the statement that
he had enriched science (we now translate his own words[254])—“not only
with the knowledge of a remarkable new vegetable acid [_Mekonsäure_
(meconic acid) which he had made known as _Opiumsäure_ in 1806], but
also with the discovery of a new alkaline salifiable base, _Morphium_,
one of the most remarkable substances, and apparently related to
ammonia.” Sertürner in fact distinctly recognised the basic nature and
the organic constitution of morphium (now called _Morphine_, _Morphia_,
or _Morphinum_), and prepared a number of its crystalline salts. He
likewise demonstrated the poisonous nature of these substances by
experiments on himself and others. Lastly, he pointed out, though
very incorrectly, the difference between morphine and the so-called
_Opium-salt_ (Narcotine) of Derosne. It is possible that this latter
chemist may have had morphine in his hands at the same time as
Sertürner, or even earlier. This honour is also due to Séguin, whose
paper “_Sur l’Opium_” read at the Institute, December 24, 1804, was,
strange to say, not published till 1814.[255] To Sertürner, however,
undoubtedly belongs the merit of first making known the existence of
organic alkalis in the vegetable kingdom,[256]—a series of bodies
practically interminable. As to opium, it still remains after nearly
seventy years a _nidus_ of new substances.

Solutions of morphine in acids or in alkalis rotate the plane of
polarization to the left.

The morphine in opium is combined with meconic acid, and is therefore
easily soluble in water.[257] The _Narcotine_ is present in the free
state, and can be extracted by chloroform, boiling alcohol, benzol,
ether, or volatile oils,[258] but not by water. It dissolves in 3
parts of chloroform, in 20 of boiling alcohol, in 21 of benzol, in 40
of boiling ether. Its alkaline properties are very weak, and it does
not affect vegetable colours. If we examine opium by the microscope we
cannot at once detect the presence of narcotine, but if first moistened
with glycerin, numerous large crystals may generally be found after the
lapse of some days. If the opium has been previously exhausted with
benzol or ether, in order to remove the narcotine, no such crystals
will be formed. Hence it follows that narcotine pre-exists in an
amorphous state.

[253] Calculated from official statements given by Eatwell in the paper
quoted at p. 50.

[254] Gilbert’s _Annalen der Physik_, lv. (1817) 57.

[255] _Annales de Chimie_, xcii (1814) 225.

[256] The Institut de France on the 27th June, 1831, awarded to
Sertürner a prize of 2000 francs—“pour avoir reconnu la nature alcaline
de la morphine, et avoir ainsi ouvert une voie qui produit de grandes
découvertes médicales.”

[257] There are exceptional cases in which it is asserted that water
does _not_ take up the whole amount of morphine.

[258] In large crystals by means of oil of turpentine.

By decomposition with sulphuric acid, narcotine yields _Cotarnine_, an
undoubted base, together with _Opianic Acid_, and certain derivatives
of the latter.

The discovery of another base, _Codeine_, was made in 1832 by Robiquet.
It dissolves in 17 parts of boiling water, forming a highly alkaline
solution which perfectly saturates acids, and exhibits in polarized
light a levogyre power. Codeine is also readily soluble at ordinary
temperatures in 7 parts amylic alcohol, and in 11 of benzol.

The codeine of commerce is in very large crystals containing 2 atoms =
5·66 per cent. of water. By crystallization from ether the alkaloid may
be obtained in small anhydrous crystals.

Since 1832 other alkaloids have been found in opium, as may be seen in
the following table, which includes all the 17 now known.[259]

A very large number of derivatives of several among them have been
prepared, of which we point out a few in smaller type. The molecular
constitution of these opium alkaloids being not yet thoroughly
settled, we add only their empirical formulæ, which however exhibit
unmistakeable connections.

_Papaverosine_ discovered by Deschamps in poppy heads (p. 42) can
hardly be absent from opium. In some points it appears to resemble
cryptopine.

Among the peculiar non-basic constituents of opium, the first to call
for notice is _Meconic Acid_, C₇H₄O₇, discovered, as already observed,
by Sertürner in 1805. It is distinguished by the red colour which it
produces with ferric salts, the same as that of ferric sulphocyanate;
but the latter only dissolves in ether. Meconic acid is soluble in
4 parts of boiling water, but immediately gives off CO₂, and the
remaining solution instead of depositing micaceous crystalline scales
of meconic acid, yields on cooling (but best after boiling with
hydrochloric acid) hard granular crystals of _Comenic Acid_, C₆H₄O₅.

_Lactic Acid_ was discovered by T. and H. Smith in the opium-liquors
produced in the manufacture of morphine. These chemists regarded it as
a peculiar body, and under the name of _Thebolactic Acid_, exhibited it
together with its copper and morphine salts at the London International
Exhibition of 1862. Its identity with ordinary lactic acid was
ascertained by Stenhouse (whose experiments have not been published)
and also by J. Y. Buchanan.[260] T. and H. Smith consider it to be a
regular constituent of Turkey opium; they obtained it as a calcium salt
to the amount of about 2 per cent., and have prepared it in this form
and in a pure state to the extent of over 100 lb. In our opinion it is
not an original constituent of poppy-juice.

[259] In 1851 Hinterberger described as a peculiar alkaloid,
_Opianine_; Dr. Hesse has examined Hinterberger’s specimen of this
body, and found (1875) it to consist of impure narcotine.

[260] _Berichte d. Deutsch. Chem. Gesellsch. zu Berlin_, iii. (1870)
182.

_NATURAL ALKALOIDS OF OPIUM_

_and a few of their Artificial Derivatives_.

    ---------------+---------------------------------+----+----+----+---
    DISCOVERED BY  |                                 | =C=| =H=| =N=| =O=
                   |                                 |    |    |    |
    Wöhler, 1844   |           Cotarnine             | 12 | 13 |  1 |  3
                   |Formed by oxidizing narcotine;   |    |    |    |
                   |      soluble in water.          |    |    |    |
    Hesse, 1871    |      =1. HYDROCOTARNINE=        | 12 | 15 |  1 |  3
                   |Crystallizable, alkaline,        |    |    |    |
                   |     volatile at 100°.           |    |    |    |
    Matthiessen    |          APOMORPHINE            | 17 | 17 |  1 |  2
     and Wright,   |From morphine, by hydrochloric   |    |    |    |
     1869          | acid. Colourless, amorphous,    |    |    |    |
                   | turning green by exposure to    |    |    |    |
                   | air; emetic.                    |    |    |    |
                   |                                 |    |    |    |
    Wright, 1871   |        DESOXYMORPHINE           | 17 | 19 |  1 |  2
                   |                                 |    |    |    |
    Sertürner,     |        =2. MORPHINE=            | 17 | 19 |  1 |  3
     1816          |Crystallizable, alkaline,        |    |    |    |
                   |   levogyre.                     |    |    |    |
    Pelletier and  |     =3. PSEUDOMORPHINE=         | 17 | 19 |  1 |  4
     Thibouméry,   |Crystallizes with H₂O; does not  |    |    |    |
     1835          |   unite even with acetic acid.  |    |    |    |
                   |                                 |    |    |    |
    Matthiessen    |         APOCODEINE              | 18 | 19 |  1 |  2
     and Burnside, |From codeine by chloride of zinc;|    |    |    |
     1871          |    amorphous, emetic.           |    |    |    |
                   |                                 |    |    |    |
    Wright, 1871   |       DESOXYCODEINE             | 18 | 21 |  1 |  2
                   |                                 |    |    |    |
    Robiquet, 1832 |       =4. CODEINE=              | 18 | 21 |  1 |  3
                   |Crystallizable, alkaline, soluble|    |    |    |
                   |  in water.                      |    |    |    |
                   |                                 |    |    |    |
    Matthiessen    |       NORNARCOTINE              | 19 | 17 |  1 |  7
     and Foster,   |                                 |    |    |    |
     1868          |                                 |    |    |    |
                   |                                 |    |    |    |
    Thibouméry,    |      =5. THEBAINE=              | 19 | 21 |  1 |  3
     1835          |Crystallizable, alkaline,        |    |    |    |
                   |  isomeric with buxine.          |    |    |    |
                   |                                 |    |    |    |
    Hesse, 1870    |         THEBENINE               | 19 | 21 |  1 |  3
                   |                                 |    |    |    |
    Hesse, 1870    |         THEBAICINE              | 19 | 21 |  1 |  3
                   |From thebaine or thebenine by    |    |    |    |
                   | hydrochloric acid.              |    |    |    |
                   |                                 |    |    |    |
    Hesse 1871     |      =6. PROTOPINE=             | 20 | 19 |  1 |  5
                   |Crystallizable, alkaline.        |    |    |    |
                   |                                 |    |    |    |
    Matthiessen    |     METHYLNORNARCOTINE          | 20 | 19 |  1 |  7
     and Foster,   |                                 |    |    |    |
     1868          |                                 |    |    |    |
                   |                                 |    |    |    |
    Hesse, 1871    |      DEUTEROPINE                | 20 | 21 |  1 |  5
                   |Not yet isolated.                |    |    |    |
                   |                                 |    |    |    |
    Hesse, 1870    |    =7. LAUDANINE=               | 20 | 25 |  1 |  4
                   |An alkaloid which, as well as its|    |    |    |
                   | salts, forms large crystals;    |    |    |    |
                   | turns orange by hydrochloric    |    |    |    |
                   | acid.                           |    |    |    |
                   |                                 |    |    |    |
    Hesse, 1878    |      =8. CODAMINE=              | 20 | 25 |  1 |  4
                   |Crystallizable, alkaline; can be |    |    |    |
                   | sublimed; becomes green by      |    |    |    |
                   | nitric acid.                    |    |    |    |
                   |                                 |    |    |    |
    Merck, 1848    |    =9. PAPAVERINE=              | 21 | 21 |  1 |  4
                   |Crystallizable, also its         |    |    |    |
                   | hydrochlorate; sulphate in      |    |    |    |
                   | sulphuric acid precipitated by  |    |    |    |
                   | water.                          |    |    |    |
                   |                                 |    |    |    |
    Hesse, 1865    |    =10. RHŒADINE=               | 21 | 21 |  1 |  6
                   |Crystallizable, not distinctly   |    |    |    |
                   | alkaline; can be sublimed;      |    |    |    |
                   | occurs also in _Papaver_        |    |    |    |
                   | _Rhœas_.                        |    |    |    |
                   |                                 |    |    |    |
    Hesse, 1865    |       RHŒAGENINE                | 21 | 21 |  1 |  6
                   |From rhœadine; Crystallizable,   |    |    |    |
                   | alkaline.                       |    |    |    |
                   |                                 |    |    |    |
    Armstrong, 1871|   DIMETHYLNORNARCOTINE          | 21 | 21 |  1 |  7
                   |                                 |    |    |    |
    Hesse, 1870    |    =11. MECONIDINE=             | 21 | 23 |  1 |  4
                   |Amorphous, alkaline, melts at    |    |    |    |
                   | 58°, not stable, the salts also |    |    |    |
                   | easily altered.                 |    |    |    |
                   |                                 |    |    |    |
    T. & H. Smith, |   =12. CRYPTOPINE=              | 21 | 23 |  1 |  5
      1864         |Crystallizable, alkaline; salts  |    |    |    |
                   | tend to gelatinize;             |    |    |    |
                   | hydrochlorate crystallizes      |    |    |    |
                   | in tufts.                       |    |    |    |
                   |                                 |    |    |    |
    Hesse, 1871    |  =13. LAUDANOSINE=              | 21 | 27 |  1 |  4
                   |Crystallizable, alkaline.        |    |    |    |
                   |                                 |    |    |    |
    Derosne, 1803  |   =14. NARCOTINE=               | 22 | 23 |  1 |  7
                   |Crystallizable, not alkaline;    |    |    |    |
                   | salts not stable.               |    |    |    |
                   |                                 |    |    |    |
    Hesse, 1870    |   =15. LANTHOPINE=              | 23 | 25 |  1 |  4
                   |Microscopic crystals not         |    |    |    |
                   | alkaline, sparingly soluble in  |    |    |    |
                   | hot or cold spirit of wine,     |    |    |    |
                   | ether or benzol.                |    |    |    |
                   |                                 |    |    |    |
    Pelletier, 1832|   =16. NARCEINE=                | 23 | 29 |  1 |  9
                   |Crystallizable (as a hydrate),   |    |    |    |
                   | readily soluble in boiling water|    |    |    |
                   | or in alkalis, levogyre.        |    |    |    |
                   |                                 |    |    |    |
    T. & H. Smith, |   =17. GNOSCOPINE=              | 34 | 36 |  2 | 11
      1868         |Crystallizable, melts at 233°,   |    |    |    |
                   | soluble in chloroform and       |    |    |    |
                   | bisulphide of carbon, slightly  |    |    |    |
                   | so in benzol, not in ether. The |    |    |    |
                   | salts have an acid reaction.    |    |    |    |
    ---------------+---------------------------------+----+----+----+

In the year 1826, Dublanc[261] observed in opium a peculiar substance
having neither basic nor acid properties which was afterwards (1832)
prepared in a state of purity by Couerbe. It has been called _Opianyl_
or (by Couerbe) _Meconine_. It has the composition C₁₀H₁₀O₄ =
C₆H₂·CH₂·O·CO(OCH₃)₂. Meconin forms prisms which fuse under water at
77° C. or _per se_ at 110°, and distil at 155°; it dissolves in about
20 parts of boiling water, from which it may be readily crystallized.
Meconin may be formed by heating narcotine with nitric acid.

An analogous substance _Meconoiosin_ C₈H₁₀O₂ = C₆H₂·(OH)₂·(CH₃)₂, has
been discovered in 1878 by T. and H. Smith. Meconoiosin is readily
soluble in 27 parts of cold water, and melts at 88° C. When heated with
slightly diluted sulphuric acid, and when the evaporation has reached
a certain point, meconoiosin produces a deep red; with meconin the
coloration is a beautiful green.

=Proportion of peculiar constituents=—The substances described in the
foregoing section exist in opium in very variable proportion; and as it
is on their presence, but especially that of morphine, that the value
of the drug depends, the importance of exact estimation is evident.

Opium whether required for analysis or for pharmaceutical preparations
has to be taken _exclusively in the dry state_. The amount of water
it contains is so uncertain that the drug must be reduced to a fixed
standard by complete desiccation at 100° C., before any given weight is
taken.

_=Morphine=_—Guibourt[262] who analysed a large number of samples of
opium, and whose skill and care in such research are not disputed,
obtained from a sample of French opium produced near Amiens, 22·88 per
cent. of morphine crystallized from spirit of wine. This percentage has
not to our knowledge been ever exceeded. From another specimen produced
in the same district he got 21·23 per cent., from a third 20·67. The
lowest percentage from a French opium was 14·96,—in each case reckoned
on material previously dried.

Chevallier extracted from opium grown by Aubergier at Clermont in the
centre of France, 17·50 per cent. of morphine. Decharmes from a French
opium obtained 17·6 per cent., and Biltz from a German opium 20 per
cent. Opium produced in Württemberg sent to the Vienna Exhibition of
1873 afforded Hesse 12 to 15 per cent. of morphine; and opium from
Silesia 9 to 10 per cent.[263]

A pure American opium collected in the State of Vermont yielded Proctor
15·75 per cent. of morphine and 2 percent of narcotine.[264]

The opium of Asia Minor furnishes very nearly the same proportions of
morphine as that of Europe. The maximum recorded by Guibourt is 21·46
per cent. obtained from a Smyrna opium sold in Paris. The mean yield of
8 samples of opium sent by Della Sudda of Constantinople to the Paris
Exhibition of 1855 was 14·78 per cent. The mean percentage of morphine
afforded by 12 other samples of Turkey opium obtained from various
sources was 14·66.

[261] _Annales de Chimie et de Physique_, xlix. (1832) 5-20.—The paper
was read before the Acad. de Méd., 13th May, 1826.

[262] _Mémoire sur le dosage de l’Opium et sur la quantité de morphine
que l’opium doit contenir_, Paris, 1862.

[263] Schroff, _Ausstellungsbericht, Arzneiwaaren_, p. 31.

[264] _Am. Journ. of Pharm._ xviii. (1870) 124.

Chevallier[265] states that Smyrna opium, of which several cases were
received by Merck of Darmstadt in 1845, afforded 12 to 13 per cent. of
pure morphine reckoned upon the drug in its _fresh and moist state_.

Fayk Bey[266] analysed 92 samples of opium of Asia Minor, and found
that half the number yielded more than 10 per cent. of morphine. The
richest afforded 17·2 per cent.

From the foregoing statements we are warranted in assuming that _good_
Smyrna opium deprived of water ought to afford 12 to 15 per cent. of
morphine, and that if the percentage is less than 10, adulteration may
be suspected.

Egyptian opium has usually been found very much weaker in morphine
than that of Asia Minor. A sample sent to the Paris Exhibition of 1865
and presented to one of us by Figari Bey of Cairo, afforded us 5·8 per
cent. of morphine and 8·7 of narcotine.

Persian opium appears extremely variable, probably in consequence of
the practice of combining it with sugar and other substances. It is
however sometimes very good. Séput[267] obtained from four samples
the respective percentages of 13·47, 11·52, 10·12, 10·08 of morphine,
the opium being free from water. Mr. Howard as already stated (p. 49)
extracted from Persian opium, not previously dried, from 8 to 10·75 per
cent. of morphine.

East Indian opium is remarkable for its low percentage of morphine,
a circumstance which we think is attributable in part to climate and
in part to a method of collection radically defective. It is scarcely
conceivable that the long period during which the juice remains in a
wet state,—always three to four weeks,—does not exercise a destructive
action on its constituents.

According to Eatwell[268] the percentage of morphine in the samples
of Benares opium officially submitted for analysis gave the following
averages.—

    1845-46    1846-47    1847-48    1848-49
     2·48       2·38       2·20       3·21

The same observer has recorded the results of the examination of
freshly collected poppy-juice, which in three instances afforded
respectively 1·4, 3·06, and 2·89 per cent. of morphine, reckoned on
the material deprived of water; but the conditions under which the
experiments were made appear open to great objection.[269]

Such very low results are not always obtained from East Indian opium.
In a sample from Khandesh furnished by the Indian Museum, we found 6·07
of morphine. Solly from the same kind obtained about 7 per cent.

_Patna Garden Opium_ which is the sort prepared exclusively for
medicinal use, afforded us 8·6 per cent. of purified morphine and 4
per cent. of narcotine.[270] Guibourt obtained from such an opium 7·72
per cent. Christison from a sample sent to Duncan of Edinburgh in
1830,[271] 9·50 per cent. of hydrochlorate of morphine.

[265] _Notice historique sur l’opium indigène_, Paris, 1852.

[266] _Monographie des Opiums de l’Empire Ottoman envoyés à
l’Exposition de Paris_, 1867.

[267] _Journ. de Pharm._ xxxix. (1861) 163.

[268] _Pharm. Journ._ xi. (1852) 361.

[269] In one case the juice was allowed to stand in a basin from 23rd
Feb. to 7th May, being “occasionally stirred”!

[270] This drug made in 1838 came from the Apothecary-General,
Calcutta, and was presented by Christison to the Kew Museum. It is in
rectangular tablets 2½ inches square and ¾ of an inch thick, cased in
wax.

[271] The actual specimen is in the Kew Museum.

Samples from the Indian Museum placed at our disposal by Dr. J. Forbes
Watson gave[272] us the following percentages of morphine:—_Medical
(Indian) Opium_, 1852-53, portion of a square brick, 4·3; _Garden
Behar Opium_, 4·6; _Abkāri Provision Opium_, _Patna_, No. 5380, 3·5;
_Sind Opium_, No. 28, 3·8; _Opium, Hyderabad_, _Sind_, 3·2 (and 5·4 of
narcotine); _Malwa Opium_, 6·1.

With regard to the percentage of morphine in _Chinese Opium_, the
following data have been obligingly furnished to us by Mr. T. W.
Sheppard, F.C.S., Opium Examiner to the Benares Opium Agency, of
analyses made by himself from samples of the drug procured in China by
Sir R. Alcock:—Szechuen opium, 2·2; Kweichow, 2·5; Yunnan, 4·1; Kansu,
5·1 per cent. Mr. S. informs us that Dr. Eatwell obtained in 1852 from
Szechuen opium 3·3, and from Kweichow opium 6·1[273] per cent.—the
opium in all instances being reckoned as _dry_. The samples examined by
Mr. S. contained 86 to 95 per cent. of dry opium, and yielded (undried)
36 to 53 per cent. of extract soluble in cold water. The proportion of
morphine in the sample of Chinese opium analysed by Dr. Jamieson (p.
55) was nearly 7·2 per cent. calculated on the dry drug.

_Pseudomorphine_—occurs only in very small quantities. Hesse found it
in some sorts of opium to the extent of 0·02 per cent.—in others still
less.

_Codeine_—has been found in Smyrna, French and Indian opium, but only
to the extent of ⅕ to ⅖ per cent. T. and H. Smith give the proportion
in Turkey opium as 0·3 per cent.[274]

_=Thebaine=_—which has likewise been obtained from French opium,
amounts in Turkey opium according to Merck to about 1 per cent. In the
latter sort T. and H. Smith found only about 8·15 per cent., but of

_Papaverine_—in the same drug, 1 per cent.

_Narcotine_—exists in opium in widely different proportions and often
in considerable abundance. Thus Schindler obtained in 1834 from a
Smyrna opium yielding 10·30 per cent. of morphine, 1·30 per cent. of
narcotine. Biltz (1831) analysed an oriental opium which afforded 9·25
per cent. of morphine and 7·50 of narcotine. Reveil (1860) obtained
from Persian opium not rich in morphine, from half as much to twice as
much narcotine as morphine. The utmost of narcotine was 9·90 per cent.
We have found in German opium of undubitable purity[275] 10·9 per cent.
of narcotine.

East Indian opium was found by Eatwell (1850) always to afford more
narcotine than morphine,—frequently twice as much. The sample from
Khandesh referred to on the opposite page, afforded us 7·7 per cent. of
pure narcotine.

French opium collected from the _Pavot œillette_ sometimes affords
neither narcotine, thebaine, nor narceine.[276]

[272] _Pharm. Journ._ v. (1875) 845.

[273] This sample, the richest of all in morphine, is noted as of “_2nd
quality_.”

[274] _Pharm. Journ._ vii. (1866) 183.

[275] Collected in 1829 by Biltz and obligingly placed in 1867 at my
disposal by his son.—F. A. F.

[276] The statement of Biltz (1831) that an opium collected by himself
from poppies grown in 1829 at Erfurt afforded 33 per cent. of narcotine
is contrary to the experience of all other chemists. The same must be
said of Mulder’s assertion respecting an opium giving 6 to 13 per cent.
of narceine.

_Narceine_—Of this substance Couerbe found in opium 0·1 per cent.; T.
and H. Smith 0·02 and Schindler 0·71.

_Cryptopine_—exists in opium in very small proportion. T. and H. Smith
state that since the alkaloid first came under their notice, they have
collected of it altogether about 5 ounces in the form of hydrochlorate,
and this small quantity in operating on many thousands of pounds of
opium. But they by no means assert that the whole of the cryptopine was
obtained.

_Rhœadine_—is also found only in exceedingly minute quantity.

_Meconic Acid_—If the average amount of morphine in opium be estimated
at 15 per cent., and the alkaloid be supposed to exist as a tribasic
meconate, it would require for saturation 3·4 per cent. of meconic
acid. Wittstein obtained rather more than 3 per cent., T. and H. Smith
4 per cent., and Decharmes 4·33. Opium produced in Vermont yielded,
according to Proctor (1870) 5·25 per cent. of meconic acid. The
quantity of acid required to unite with the other bases assuming them
to exist as salts can be but extremely small.

=Estimation of Morphine in Opium=—The practical valuation of opium
turns in the first instance upon the estimation of the water present
in the drug, and in the second upon the proportion which the latter
contains of morphine.[277]

The first question is determined by exposing a known quantity of the
drug divided into small slices or fragments to the heat of a water-bath
until it cease to lose weight.

For the estimation of the morphine many processes have been devised,
but none is perfectly satisfactory.[278] That which we recommend is
thus performed:—Take of opium previously dried at 100° C., as above
stated, and powdered, 10 grammes; shake it with 100 grammes alcohol
0·950 sp. gr., and filter after a day or two. The weight of the liquid
should be made equal to 100 grammes. Add to it 50 grammes of ether and
2 grammes of ammonia water 0·960 sp. gr.; collect the crystals of opium
which separate slowly, after a day or two, dry them at 100° C., and
weigh them.—On applying this method to Indian opium, we were but little
satisfied with it.

=Commerce=—By official statistics it appears that the quantity of opium
imported into the United Kingdom in 1872 was 356,211 lb., valued at
£361,503. The imports from Asiatic and European Turkey are stated in
the same tables thus:—

      1868          1870          1872          1874
    317,133 lb.   276,691 lb.   325,572 lb.   514,000 lb.

It is thus evident that the drug used in Great Britain is chiefly
Turkish. The import of opium from Persia has been very irregular. In
1871, 21,894 lb. are reported as received from that country; in 1872,
none.

[277] In selecting a sample for analysis, care should be taken that
it fairly represents the bulk of the drug. We prefer to take a little
piece from each of several lumps, mix them in a mortar, and weigh from
the mixed sample the required quantity.

[278] See also Proctor, _Pharm. Journ._ vii. (1876) 244, and _Yearbook
of Pharm._ 1877. 528.

Except that a little Malwa opium has occasionally been imported, it
may be asserted the opium of India is entirely unknown in the English
market, and that none of it is to be found even in London in the
warehouse of any druggist.

As to other countries, we may point out that in 1876 the import of
opium (prepared) into the colony of Victoria was valued at £104,557.

=Uses=—Opium possesses sedative powers which are universally known. In
the words of Pereira, it is the most important and valuable medicine of
the whole Materia Medica; and we may add, the source by its judicious
employment of more happiness and by its abuse of more misery[279] than
any other drug employed by mankind.

=Adulteration=—The manifold falsifications of opium have been already
noticed, and the method by which its more important alkaloid may be
estimated has been pointed out. Moreover as already stated, neither
tannic acid nor starch ever occur in genuine opium; and the proportion
of ash left upon the incineration of a good opium does not exceed 4
to 8 per cent. of the dried drug. Another criterion is afforded by
the amount soluble in cold water which ought to exceed 55 per cent.
reckoned on dry opium. Finally, if we are correct, the gum contained in
pure opium is distinct from gum arabic, being precipitable by neutral
acetate of lead. If we exhaust with water opium falsified with gum
arabic, the mucilage peculiar to opium will be precipitated by neutral
acetate of lead, the liquid separated from the precipitate will still
contain the gum arabic which may be thrown down by alcohol. If gum is
present to some extent, an abundant precipitate is produced.




CRUCIFERÆ.


SEMEN SINAPIS NIGRÆ.

_Black, Brown or Red Mustard_; F. _Moutarde noire ou grise_; G.
_Schwarzer Senf_.

=Botanical Origin=—_Brassica nigra_ Koch (_Sinapis nigra_ L.). Black
Mustard is found wild over the whole of Europe excepting the extreme
north. It also occurs in Northern Africa, Asia Minor, Mesopotamia, the
Caucasian region, Western India, as well as in Southern Siberia and
China. By cultivation, which is conducted on a large scale in many
countries (as Alsace, Bohemia, Holland, England and Italy), it has
doubtless been diffused through regions where it did not anciently
exist. It has now become naturalized both in North and South America.

=History=—Mustard was well known to the ancients. Theophrastus mentions
it as Νάπμ,—Dioscorides as Νάπμ or Σίνηπι. Pliny notices three kinds
which have been referred by Fée[280] to _Brassica nigra_ Koch, _B.
alba_ Hook. f. et Th., and to a South European species, _Diplotaxis
erucoides_ DC. (_Sinapis erucoides_ L.). The use of mustard seems up
to this period to have been more medicinal than dietetic. But from
an edict of Diocletian, A.D. 301[281] in which it is mentioned along
with alimentary substances, we must suppose it was then regarded as a
condiment at least in the eastern parts of the Roman Empire.

[279] See Tingling, J. F. B., _The poppy-plague and England’s crime_,
London, 1876 (192 p.); Turner, F. S. (Secretary of the Anglo-Oriental
Society for the Suppression of the Opium Trade), _British Opium Policy
and its results to India and China_. London, 1876 (308 pages); Sir Edw.
Fry, _England, China, and Opium_, 1878 (61 p.).

[280] _Botanique et Matière Méd. de Pline_, ii. (1833) 446.

[281] Mommsen in _Berichte der sächs. Gesellsch. der Wissenschaften zu
Leipzig_, 1851. 1-80.

In Europe during the middle ages mustard was a valued accompaniment
to food, especially to the salted meat which constituted a large
portion of the diet of our ancestors during the winter.[282] In the
Welsh “Meddygon Myddvai,” of the 13th century, a paragraph is devoted
to the “Virtues of Mustard.” In household accounts of the 13th and
14th centuries, mustard under the name of _Senapium_ is of constant
occurrence.

Mustard was then cultivated in England, but not as it would seem very
extensively. The price of the seed between A.D. 1285 and 1395 varied
from 1_s._ 3_d._ to 6_s._ 8_d._ per quarter, but in 1347 and 1376 it
was as high as 15_s._ and 16_s._[283] In the accounts of the abbey
of St. Germain-des-Prés in Paris, commencing A.D. 800, mustard is
specifically mentioned as a regular part of the revenue of the convent
lands.[284]

The essential oil of mustard was, apparently, noticed about the year
1660 by Nicolas Le Febvre (see in the article Rad. Inulae), more
distinctly in 1732 by Boerhaave. Its acridity and high specific
gravity were pointed out by Murray.[285] Thibierge in 1819 observed
that sulphur was one of the constituents of the oil, and Guibourt[286]
stated that it is not pre-existing in the seed.

=Production=—Mustard is grown in England only on the richest alluvial
soils, and chiefly in the counties of Lincolnshire and Yorkshire. Very
good seed is produced in Holland.

=Description=—The pod of _Brassica nigra_ is smooth, erect, and closely
pressed against the axis of the long slender raceme. It has a strong
nerve on each of its two valves and contains in each cell from 4 to
6 spherical or slightly oval seeds. The seeds are about ¹/₂₅ of an
inch in diameter and ¹/₅₀ of a grain in weight; they are of a dark
reddish-brown. The surface is reticulated with minute pits, and often
more or less covered with a whitish pellicle which gives to some seeds
a grey colour.[287] The testa which is thin, brittle and translucent
encloses an exalbuminous embryo having two short cotyledons folded
together longitudinally and forming a sort of trough in which the
radicle lies bent up. The embryo thus coiled into a ball completely
fills the testa; the outer cotyledon is thicker than the inner, which
viewed in transverse section seems to hold the radicle as a pair
of forceps. The seeds when pulverized have a greenish yellow hue.
Masticated they have for an instant a bitterish taste which however
quickly becomes pungent. When triturated with water they afford a
yellowish emulsion emitting a pungent acrid vapour which affects the
eyes, and has a strong acid reaction. The seeds powdered dry have no
such pungency. When the seeds are triturated with solution of potash,
the pungent odour is not evolved; nor when they are boiled in water.
Neither is the acridity developed on triturating them with alcohol,
dilute mineral acids, or solution of tannin, or even with water when
they have been kept in powder for a long time.

[282] Enclosed pasture land in England was rare, and there was but
scanty provision for preserving stock through the winter, root crops
being unknown. Hence in November there was a general slaughtering of
sheep and oxen, the flesh of which was salted for winter use.—See also
_Pharm. Journ._ viii. (1876, April 27) 862.

[283] Rogers, _Hist. of Agriculture and Prices in England_, i. (1866)
223.

[284] Guérard, _Polyptique de l’Abbé Irminon_, Paris, i. (1844) 715.

[285] _Apparatus medicaminum_, ii. (1794) 399.

[286] _Journ. de Pharm._ xvii. (1831) 360.

[287] The grey colour of the seed, which is attributed to rain during
the ripening, is very detrimental to its value. The great aim of the
grower is to produce seed of a bright reddish-brown, with no grey seed
intermixed.

=Microscopic Structure=—The whitish pellicle already mentioned, which
covers the seed, is made up of hexagonal tabular cells. The epidermis
consists of one row of densely packed brown cells, radially elongated
and having strong lateral and inner walls. Their outer walls on the
other hand are thin and not coloured; they are not clearly obvious
when seen under oil, but swell up very considerably in presence of
water, emitting mucilage.[288] Seeds immersed in water become therefore
covered with a glossy envelope, levelling down the superficial
inequalities, so that the wet seed appears smooth. The tissue of the
cotyledons exhibits large drops of fatty oil and granules of albumin.

=Chemical Composition=—By distilling brown mustard with water, the seed
having been previously macerated, the pungent principle, _Essential Oil
of Mustard_, is obtained.

The oil, which has the composition SCN(C₃H⁵), (allyl isosulphocyanate),
boils at 148° C.; it has a sp. gr. of 1·017, no rotatory power, and
is soluble without coloration or turbidity in three times its weight
or more of cold strong sulphuric acid. To this oil is due the pungent
smell and taste of mustard and its inflammatory action on the skin. As
already pointed out, mustard oil is not present in the dry seeds, but
is produced only after they have been comminuted and mixed with water,
the temperature of which should not exceed 50° C.

The remarkable reaction which gives rise to the formation of
mustard oil was explained by Will and Körner in 1863. They obtained
from mustard a crystallizable substance, then termed _Myronate of
potassium_, now called _Sinigrin_. It is to be regarded, according to
the admirable investigations of these chemists, as a compound of

    Isosulphocyanate of allyl or mustard oil   C₄  H₆  NS
    Bisulphate of potassium                        H   KS    O₄
    Sugar (dextro-glucose)                     C₆  H₁₂       O₆
                                               -----------------
    so that the formula                        C₁₀ H₁₈  KNS₂  O₁₀

is that of sinigrin. It does in fact split into the above-mentioned
three substances when dissolved in water and brought into contact with
_Myrosin_.

[288] Most minutely described and figured by F. von Höhnel, in
Haberlandt’s _Untersuchungen auf dem Gebiete des Pflanzenbaues_, i.
(Vienna, 1875) 171-202.

This albuminous body discovered by Bussy in 1839, but the composition
of which has not been made out, likewise undergoes a certain
decomposition under these circumstances. Sinigrin may likewise be
decomposed by alkalis and, according to Ludwig and Lange, by silver
nitrate. These chemists obtained sinigrin from the seeds in the
proportion of 0·5 per cent.; Will and Körner got 0·5 to 0·6 per cent.
The extraction of the substance is therefore attended with great loss,
as the minimum yield of volatile oil, 0·42 per cent. indicates 2·36 of
potassium myronate.

The aqueous solution of myrosin coagulates at 60° C. and then becomes
inactive: hence mustard seed which has been heated to 100° C. or has
been roasted yields no volatile oil, nor does it yield any if powdered
and introduced at once into boiling water. The proportion of myrosin in
mustard has not been exactly determined. The total amount of nitrogen
in the seed is 2·9 per cent. (Hoffmann) which would correspond to 18
per cent. of myrosin, supposing the proportion of nitrogen in that
substance to be the same as in albumin, and the total quantity of
nitrogen to belong to it. Sometimes black mustard contains so little of
it, that an emulsion of white mustard requires to be added in order to
develop all the volatile oil it is capable of yielding.

An emulsion of mustard or a solution of pure sinigrin brought into
contact with myrosin, frequently deposits sulphur by decomposition of
the allyl sulphocyanide, hence crude oil of mustard sometimes contains
a considerable proportion (even half) of _Allyl cyanide_, C₄H₅N,
distinguished by its lower sp. gr. (0·839) and lower boiling point
(118° C.).

The seeds, roots, or herbaceous part of many other plants of the order
_Cruciferæ_ yield a volatile oil composed in part of mustard oil and in
part of allyl sulphide

             C₂H₅}
    C₆H₁₀S =     } S,
             C₃H₅}

which latter is likewise obtainable from the bulbs of garlic. Many
_Cruciferæ_ afford from their roots or seeds chiefly or solely oil
of mustard, and from their leaves oil of garlic. As to other plants,
the roots of _Reseda lutea_ L. and _R. luteola_ L. have been shown by
Volhard (1871) to afford oil of mustard.[289] The strong smell given
off by the crushed seeds or roots of several Mimoseæ, as for instance,
_Albizzia lophantha_ Benth. (_Acacia_ Willd.) is perhaps due to some
allied compound.

The artificial preparation of mustard oil was discovered in 1855 by
Zinin, and at the same time also by Berthelot and De Luca. It may be
obtained in decomposing bromide of allyl by means of sulphocyanate of
ammonium:—

    C₃H₅Br · SCN(NH₄) = NH₄Br · C₃H₅SCN.

The liquid C₃H₅SCN, boiling at 161°, is sulphocyanate of allyl; if it
is gently warmed with a little alcoholic potash, and then acidulated,
the red coloration of ferric sulphocyanate is produced on addition of
perchloride of iron, but by submitting the sulphocyanate of allyl to
distillation it is at once transformed in the isosulphocyanate, _i.e._
in mustard oil; the latter is not coloured by ferric salts, but it
would appear that in the cold emulsion of mustard, even at 0°, a little
sulphocyanate makes also its appearance.

Mustard submitted to pressure affords about 23 per cent.[290] of a
mild-tasting, inodorous, non-drying oil, solidifying when cooled to
-17·5° C., and consisting of the glycerin compounds of stearic, oleic
and _Erucic_ or _Brassic Acid_. The last named acid, C₂₂H₄₂O₂, occurs
also in the fixed oil of white mustard and of rape, and is homologous
with oleic acid. Darby (1849) has pointed out the existence of another
body, _Sinapoleic Acid_, C₂₀H₃⁸O₂, which occurs in the fixed oil of
both black and white mustard. Goldschmiedt, in 1874, ascertained the
presence also of _Behenic Acid_, C₂₂H₄₄O₂ in black mustard. Sinigrin
being not altered by the extraction of the fatty oil, either by
pressure or by means of bisulphide of carbon, the powdered seed,
deprived of fatty oil, still yields the whole amount of the irritating
“essential” oil. This important fact has been ingeniously used by
Rigollot[291] for the preparation of his mustard paper.

[289] See also _Radix Armoraciæ_, p. 68.

[290] I have obtained as much as 33·8 per cent. by means of boiling
ether.—F. A. F.

[291] _Journ. de Pharm._ vi. (1867) 269.

Mustard seed when ripe is devoid of starch; the mucilage which its
epidermis affords amounts to 19 per cent. of the seed (Hoffmann).
The ash constituents amounting to 4 per cent. consist chiefly of the
phosphates of calcium, magnesium, and potassium.

=Uses=—Black mustard is employed in the form of poultice as a powerful
external stimulant; but it is rarely used in its pure state, as
the _Flour of Mustard_ prepared for the table, which contains in
addition white mustard, answers perfectly well and is at hand in every
house.[292]

The essential oil of mustard dissolved in spirit of wine is
occasionally prescribed as a liniment.

=Substitute=—_Brassica juncea_ Hook. f. et Th. (_Sinapis juncea_
L.) is extensively cultivated throughout India (where _B. nigra_ is
rarely grown), Central Africa, and generally in warm countries where
it replaces _B. nigra_ and is applied to the same uses. Its seeds
constitute a portion of the mustard of Europe, as we may infer from
the fact that British India exported in the year 1871-72, of “_Mustard
seed_” 1418 tons, of which 790 tons were shipped to the United Kingdom,
and 516 tons to France.[293] _B. juncea_ is largely grown in the south
of Russia and in the steppes north-east of the Caspian where it appears
to flourish particularly well in the saline soil. At Sarepta in the
Government of Saratov, an establishment has existed since the beginning
of the present century where this sort of mustard is prepared for use
to the extent of 800 tons of seed annually. The seeds make a fine
yellow powder employed both for culinary and medicinal purposes. By
pressure they yield more than 20 per cent. of fixed oil which is used
in Russia like the best olive oil. The seeds closely resemble those
of _B. nigra_ and afford when distilled the same essential oil; it is
largely made at Kiew.


SEMEN SINAPIS ALBÆ.

_White Mustard_; F. _Moutarde blanche ou Anglaise_; G. _Weisser Senf_.

=Botanical Origin=—_Brassica alba_ Hook. f. et Th. (_Sinapis alba_ L.)
This plant appears to belong to the more southern countries of Europe
and Western Asia. According to Chinese authors[294] it was introduced
into China from the latter region. Its cultivation in England is of
recent introduction, but is rapidly extending.[295] The plant is not
uncommon as a weed on cultivated land.

[292] The best _Flour of Mustard_ such as is made by the large
manufacturers, contains nothing but brown and white mustard seeds. But
the lower and cheaper qualities made by the same firms contain flour,
turmeric, and capsicum. Unmixed flour of Black Mustard is however kept
for those who care to purchase it.

[293] _Annual Statement of the Trade and Navigation of British India_,
Calcutta, 1872. 62.

[294] Bretschneider, _Study of Chinese Botan. Works_, 1870. 17.

[295] Morton’s _Cycloped. of Agriculture_, ii. (1855) 440.

=History=—White mustard was used in former times indiscriminately
with the brown. In the materia medica of the _London Pharmacopœia_
of 1720 the two sorts are separately prescribed. The important
chemical distinction between them was first made known in 1831 by
Boutron-Charlard and Robiquet.[296]

=Production=—White mustard is grown as an agricultural crop in Essex
and Cambridgeshire.

=Description=—_Brassica alba_ differs from _B. nigra_ in having the
pods bristly and spreading. They are about an inch long, half the
length being occupied by a flat veiny beak. Each pod contains 4 to 6
yellowish seeds about ¹/₁₂ of an inch in diameter and ⅒ of a grain in
weight. The brittle, nearly transparent and colourless testa encloses
an embryo of a bright pure yellow and of the same structure as that
of black mustard. The surface of the testa is likewise pitted in a
reticulate manner, but so finely that it appears smooth except under a
high magnifying power.

When triturated with water the seeds form a yellowish emulsion of very
pungent taste, but it is inodorous and does not under any circumstances
yield a volatile oil. The powdered seeds made into a paste with cold
water act as a highly stimulating cataplasm. The entire seeds yield to
cold water an abundance of mucilage.

=Microscopic Structure=—The epidermal cells of white mustard afford a
good illustration of a mucilage-yielding layer such as is met with,
under many variations, in the seeds of numerous plants. The cuticle
consists of large vaulted cells, exhibiting very regular hexagonal
outlines when cut across.[297] The inner layer of the epidermis is
made up of thin-walled cells, which when moistened swell and give off
the mucilage. In the dry state or seen under oil, the outlines of the
single cells of this layer are not distinguishable. The tissue of
the cotyledons is loaded with drops of fatty oil and with granular
albuminoid matter; starch which is present in the seed while young, is
altogether absent when the latter reaches maturity.

=Chemical Composition=—White mustard deprived of fatty oil yields to
boiling alcohol colourless crystals of _Sinalbin_, an indifferent
substance, readily soluble in cold water, but sparingly in cold
alcohol. From the able investigations of Will (1870) it follows, that
it is to be regarded as composed of three bodies, namely:

    Sulphocyanate of Acrinyl   C⁸  H₇   N  S  O
    Sulphate of Sinapine       C₁₆ H₂₅  N  S  O₉
    Sugar                      C₆  H₁₂        O₆
                               -----------------
    so that the formula        C₃₀ H₄₄  N₂ S₂ O₁₆

[296] _Journ. de Pharm._ xvii. (1831) 279.

[297] An interesting object for the polarizing microscope.

represents according to Will the composition of sinalbin. It is
actually resolved into these three substances when placed at ordinary
temperatures, in contact with water and _Myrosin_, the latter of
which is a constituent of white mustard as well as of brown (p. 66).
The liquid becomes turbid, the first of the above-named substances
separates (together with coagulated albumin) as an oily liquid,
not soluble in water, but dissolving in alcohol or ether. This
_Sulphocyanate of Acrinyl_ is the rubefacient and vesicating principle
of white mustard. It does not pre-exist, as shown by Will, in the
seed, and cannot be obtained by distillation. By treating it with a
salt of silver, Will obtained crystals of cyanide of acrinyl, C₈H₇NO:
by warming it (or sinalbin itself, or an alcoholic extract of the
seed) with caustic potash, sulphocyanide of potassium is produced. The
presence of the latter may be indicated by adding a drop of perchloride
of iron, when a blood-red coloration will be produced.[298]

_Sulphate of Sinapine_ imparts to the emulsion of white mustard, in
which it is formed, an acid reaction. Sinapine is itself an alkaloid,
which has not yet been isolated, as it is very liable to change. Thus
its solution on addition of a trace of alkali immediately assumes a
bright yellow colour indicating decomposition, and a similar colour is
produced in an aqueous extract of the seed.

The above statements show, that the chemical properties of sinalbin
and its derivatives correspond closely with those of sinigrin (p. 66)
and the substances which make their appearance in an emulsion of black
mustard.

The other constituents of white mustard seed are nearly the same as
those of black. The fat oil appears to yield in addition to the acids
mentioned at p. 67, _Benic_ or _Behenic Acid_, C₂₂H₄₄O₂. White mustard
is said to be richer than black in myrosin, so that, as explained in
the previous article, the pungency of the latter may be often increased
by an addition of white mustard. By burning white mustard dried at
100° C., with soda-lime, we obtained from 4·20 to 4·30 per cent. of
nitrogen, answering to about 28 per cent. of protein substances.[299]
The fixed oil of the seed amounts to 22 per cent. The mucilage as
yielded by the epidermis is precipitable by alcohol, neutral lead
acetate, or ferric chloride, and is soluble in water after drying.

_Erucin_ and _Sinapic Acid_, mentioned by Simon (1838)[300] as
peculiar constituents of white mustard, are altogether doubtful, yet
may deserve further investigation. The sinapic acid of Von Babo and
Hirschbrunn[301] (1852) is a product of the decomposition of sinapine.

=Uses=—White Mustard seed reduced to powder and made into a paste
with cold water act as a powerful stimulant when applied to the skin,
notwithstanding that such paste is entirely wanting in essential oil.
But for sinapisms they are actually used only in the form of the _Flour
of Mustard_ which is prepared for the table and which contains also
Brown Mustard seed.

[298] The red compound thus formed with sulphocyanide is readily
soluble in ether, yet in the case of white mustard we find it _not_ to
be so.

[299] Experiments performed by Mr. Weppen in my laboratory, 1869.—F. A.
F.

[300] Gmelin, _Chemistry_, xiv. (1860) 521 and 529.

[301] Ibid. 521.


RADIX ARMORACIÆ.

_Horse-radish_; F. _Raifort_ (_i.e._ _racine forte_), _Cran de
Bretagne_; G. _Meerrettig_.

=Botanical Origin=—_Cochlearia Armoracia L._, a common perennial with
a stout tapering root, large coarse oblong leaves with long stalks,
and erect flowering racemes 2 to 3 feet high. It is indigenous to the
eastern parts of Europe, from the Caspian through Russia and Poland to
Finland. In Britain and in other parts of Europe from Sicily to the
polar circle, it occurs cultivated or semi-wild; in the opinion of
Schübeler[302] it is not truly indigenous to Norway.

=History=—The vernacular name _Armon_ is stated by Pliny[303] to be
used in the Pontic regions to designate the _Armoracia_ of the Romans,
the Wild Radish (ῤαϕανὶς ἀγρία) of the Greeks, a plant which cannot be
positively identified with that under notice.

Horse-radish is called in the Russian language _Chren_, in Lithuanian
_Krenai_, in Illyrian _Kren_, a name which has passed into several
German dialects, and as _Cran_ or _Cranson_ into French.

From these and similar facts, De Candolle[304] has drawn the conclusion
that the propagation of the plant has travelled from Eastern to Western
Europe.

Both the root and leaves of horse-radish were used as a medicine
and also eaten with food in Germany and Denmark during the middle
ages.[305] But the use of the former was not common in England until
a much later period. The plant is mentioned in the _Meddygon Myddfai_
and was known in England as _Red-cole_ in the time of Turner, 1568,
but is not quoted by him[306] as used in food, nor is it noticed by
Boorde,[307] 1542, in his chapter on edible roots. Gerarde[308] at the
end of the 16th century remarks that horse-radish—“is commonly used
among the Germans for sauce to eat fish with, and such like meats, as
we do mustard.” Half a century later the taste for horse-radish had
begun to prevail in England. Coles[309] (1657) states that the root
sliced thin and mixed with vinegar is eaten as a sauce with meat as
among the Germans. That the use of horse-radish in France had the same
origin is proved by its old French name _Moutarde des Allemands_.

The root to which certain medicinal properties had always been
assigned, was included in the materia medica of the London
Pharmacopœias of the last century under the name of _Raphanus
rusticanus_.

=Description=—The root which in good ground often attains a length
of 3 feet and nearly an inch in diameter, is enlarged in its upper
part into a crown, usually dividing into a few short branches each
surmounted by a tuft of leaves, and annulated by the scars of fallen
foliage; below the crown it tapers slightly, and then for some distance
is often almost cylindrical, throwing off here and there filiform
and long slender cylindrical roots, and finally dividing into two or
three branches. The root is of a light yellowish-brown; internally it
is fleshy and perfectly white, and has a short non-fibrous fracture.
Before it is broken it is inodorous, but when comminuted it immediately
exhales its characteristic pungent smell. Its well-known pungent taste
is not lost in the root carefully dried and not kept too long.

[302] _Pflanzenwelt Norwegens_ (1873) 296.

[303] Lib. xix. c. 26 (Littré’s translation).

[304] _Géographie Botanique_, ii. (1855) 655.

[305] Meyer, _Geschichte der Botanik_, iii. (1856) 531; also Schübeler
_l. c._; Pfeiffer, _Buch der Natur von Konrad von Megenberg_,
Stuttgart, 1861. 418.

[306] _Herball_, part 2. (1568) 111.

[307] _Dyetary of Helth_, Early English Text Society, 1870. 278.

[308] _Herball_, edited by Johnson, 1636, 240.

[309] _Adam in Eden, or Nature’s Paradise_, Lond. 1657. chap. 256.

A transverse section of the fresh root displays a large central column
with a radiate and concentric arrangement of its tissues, which are
separated by a small greyish circle from the bark, whose breadth is
from ½ to 2 lines. In the root branches there is neither a well-defined
liber nor a true pith. The short leaf-bearing branches include a large
pith surrounded by a circle of woody bundles. The bark adheres strongly
to the central portion, in which zones of annual growth are easily
perceptible, at least in older specimens.

=Microscopic Structure=—The corky layer is made up of small tabular
cells as usual in suberous coats. In the succeeding zone of the
middle bark, thick-walled yellow cells are scattered through the
parenchyme, chiefly at the boundary line of the corky layer. In the
root the cellular envelope is not strikingly separated from the
liber, whilst in its leafy branches this separation is well marked by
wedge-shaped liber bundles, which are accompanied by a group of the
yellow longitudinally-elongated stone-cells. The woody bundles contain
a few short yellow vessels, accompanied by bundles of prosenchymatous,
not properly woody cells. The centre, in the root, shows these woody
bundles to be separated by the medullary parenchyma; in the branches
the central column consists of an uniform pith without woody bundles,
the latter forming a circle close to the cambium. The parenchyma of the
whole root collected in spring is loaded with small starch granules.

=Chemical Composition=—Among the constituents of horse-radish root (the
chemical history of which is however far from perfect) the volatile
oil is the most interesting. The fresh root submitted to distillation
with water in a glass retort, yields about ½ per mille of oil which is
identical with that of Black Mustard as proved in 1843 by Hubatka. He
combined it with ammonia and obtained crystals of thiosinammine, the
composition of which agreed with the thiosinammine from mustard oil.

An alcoholic extract of the root is devoid of the odour of the oil, but
this is quickly evolved on addition of an emulsion of _White_ Mustard.
The essential oil does not therefore pre-exist, but only sinigrin
(myronate of potassium) and an albuminoid matter (myrosin) by whose
mutual reaction in the presence of water it is formed (p. 66). This
process does not go on in the growing root, perhaps because the two
principles in question are not contained in the same cells, or else
exist together in some condition that does not allow of their acting on
each other,—a state of things analogous to that occurring in the leaves
of _Lauro-cerasus_.

By exhausting the root with water either cold or hot, the sinigrin is
decomposed and a considerable proportion of bisulphate is found in the
concentrated decoction. Alcohol removes from the root some fatty matter
and sugar (Winckler 1849). Salts of iron do not alter thin slices of
it, tannic matters being absent. The presence of myrosin, which at
present has been inferred rather than proved, ought to be further
investigated. The root dried at 100° C afforded 11·15 per cent. of ash
to Mutschler (1878).

=Uses=—An infusion or a distilled spirit of horse-radish is reputed
stimulant, diaphoretic, and diuretic, but is not often employed.

=Substitute=—In India the root of _Moringa pterygosperma_ Gärtn. is
considered a substitute for horse-radish. It yields by distillation an
essential oil of disgusting odour which Broughton, who obtained it in
minute quantity, has assured us is not identical with that of mustard
or of garlic.




CANELLACEÆ.


CORTEX CANELLÆ ALBÆ.

_Canella Bark_, _Canella Alba Bark_; F. _Canelle blanche_; G.
_Canella-Rinde_.

=Botanical Origin=—_Canella alba_ Murray,[310] a tree, 20 to 30 or
even 50 feet in height, found in the south of Florida, the Bahama
Islands (whence alone its bark is exported), Cuba, Jamaica, Ste. Broix,
Guadaloupe, Martinique, Barbadoes and Trinidad.

=History=—The drug was first mentioned in 1605 by Clusius,[311] who
remarks that it had been then newly brought to Europe and had received
the name of _Canella alba_ (White Cinnamon). It was afterwards known
as _Costus Corticosus_, _Costus dulcis_, _Cassia alba_, _Cassia lignea
Jamaicensis_ or _Jamaica Winter’s Bark_. Dale[312] writing in 1693
notices it as not unfrequently sold for Winter’s Bark. Pomet[313]
(1694) describes it as synonymous with Winter’s Bark, and observes that
it is common, yet but little employed.

The drug is mentioned by most subsequent writers, some of whom like
Pomet probably confounded it with the bark of _Cinnamodendron_ (p.
19). It is usually described as produced in Jamaica or Guadaloupe,
from which islands no Canella alba is now exported. On the other hand,
New Providence, one of the Bahamas whence the Canella alba of the
present day is shipped, is not named. Nor do we find any allusion to
the drug in the records of the Company (1630-50) which was formed for
the colonization of New Providence and the other islands of the group,
though their staple productions are frequently enumerated.[314]

_Canella alba_ Murr. was described and figured by Sloane (1707) and
still better by Patrick Brown in 1789, and Olaf Swartz in 1791.[315]

[310] Fig. in Bentley and Trimen, _Medic. Plants_, part 6 (1876).

[311] _Exotica_, 78.

[312] _Pharmacologia_, 432.

[313] _Hist. des Drog._ part i. 130.

[314] _Calendar of State Papers, Colonial Series_, 1584-1660, Lond.
1860.

[315] O. Swartz, Trans. of the Linnean Soc., i. 96. See also Bonnet,
_Monographie des Canellées_, 1876.

=Collection=—In the Bahamas, where the drug is known as _White-Wood
Bark_ or _Cinnamon Bark_, it is collected thus:—preparatory to being
stripped from the wood, the bark is gently beaten with a stick, which
removes the suberous layer. By a further beating, the remaining bark is
separated, and having been peeled off and dried, is exported without
further preparation.[316]

=Description=—Canella bark occurs in the form of quills, more or less
crooked and irregular, or in channelled pieces from 2 or 3 up to 6,
8, or more inches in length, ½ an inch to 1 or 2 inches in width, and
a line or two in thickness. The suberous layer which here and there
has escaped removal is silvery grey, and dotted with minute lichens.
Commonly, the external surface consists of inner cellular layers
(_mesophlœum_) of a bright buff, or light orange-brown tint, often a
little wrinkled transversely, and dotted (but not always) with round
scars. The inner surface is whitish or cinnamon-coloured, either smooth
or with slight longitudinal striæ. Some parcels of canella show the
bark much bruised and longitudinally fissured by the above-mentioned
process of beating. The bark breaks transversely with a short granular
fracture, which distinctly shows the three, or in uncoated specimens
the two, cortical layers, that of the liber being the largest, and
projecting by undulated rays or bundles into the middle layer, which
presents numerous large and unevenly scattered oil-cells of a yellow
colour.

Canella has an agreeable cinnamon-like odour, and a bitter, pungent
acrid taste.[317] Even the corky coat is somewhat aromatic.

=Microscopical Structure=—The spongy suberous coat consists of very
numerous layers of large cells with thin walls, showing an undulated
rather than rectangular outline. The next small zone is constituted
of sclerenchymatous cells in a single, double, or triple row, or
forming dense but not very extensive groups. This tissue is sometimes
(in unpeeled specimens) a continuous envelope, marking the boundary
between the corky layer and the middle portion of the cellular layer;
but an interruption in this thick-walled tissue often takes place when
portions of it are enveloped and separated by the suberous layer.

The proper cellular envelope shows a narrow tissue with numerous very
large cells filled with yellow essential oil. The liber forming the
chief portion of the whole bark, exhibits thin prosenchymatous cells,
which on traverse section form small bands of a peculiar horny or
cartilaginous appearance, on which account they have been distinguished
as _horny liber_ (_Hornbast_ of German writers).[318] The liber-fibres
show reticulated marks due to the peculiar character of the secondary
deposits on their cell-walls. The oil-cells in the liber are less
numerous and smaller; the medullary rays are not very obvious unless
on account of the crystalline tufts of oxalate of calcium deposited in
the latter. This crystalline oxalate retains air obstinately, and has a
striking dark appearance.

[316] Information communicated to me by the Hon. J. C. Lees,
Chief-Justice of the Bahamas. The second beating would seem to be not
always required.—D. H.

[317] A specimen in Sloane’s collection in the British Museum labelled
“_Cortex Winteranus of the Isles_,” but under the microscope seen to
be absolutely identical with canella alba, still retains its proper
fragrance after nearly two centuries.—F. A. F.

[318] First figured and described by Oudemaus, —_Aanteekeningen op het
... Gedeelte der Pharm. Neerlandica_, 1854-56. 467.

=Chemical Composition=—The most interesting body in canella is the
volatile oil, examined in 1843 under Wöhler’s direction by Meyer and
von Reiche, who obtained it in the proportion of 0·94 from 100 parts of
bark. They found it to consist of four different oils, the first being
identical with the _Eugenol_ or _Eugenic Acid_ of oil of cloves; the
second is closely allied to the chief constituent of cajuput oil. The
other oils require further examination.[319]

The bark, of which we distilled 20 lb., afforded 0·74 per cent. of
oil. This when distilled with caustic potash in excess was found to
be composed of 2 parts of the acid portion and 1 part of the neutral
hydrocarbon; the latter has an odour suggesting a mixture of peppermint
and cajuput.

Meyer and von Reiche evaporated the aqueous decoction of canella, and
removed from the bitter extract by alcohol 8 per cent. of mannite,
which they ascertained to be the so-called _Canellin_ described in 1822
by Petroz and Robinet.

The bark yielded the German chemists 6 per cent. of ash, chiefly
carbonate of calcium. The bitter principle has not yet been isolated.
An aqueous infusion is not blackened by a persalt of iron.

=Commerce=—Canella alba is collected in the Bahama Islands and shipped
to Europe from Nassau in New Providence, the chief seat of trade in the
group. In 1876 the export of the bark amounted to 125 cwt.

=Uses=—The bark is an aromatic stimulant, now but seldom employed. It
is used by the West Indian negroes as a condiment.




BIXINEÆ.


SEMEN GYNOCARDIÆ.

_Chaulmugra Seed._

=Botanical Origin=—_Gynocardia odorata_ R. Br. (_Chaulmoogra_ Roxb.,
_Hydnocarpus_ Lindl.), a large tree[320] with a globular fruit of the
size of a shaddock, containing numerous seeds immersed in pulp. It
grows in the forests of the Malayan peninsula and Eastern India as
far north as Assam, extending thence along the base of the Himalaya
westward to Sikkim.

=History=—The inhabitants of the south-eastern countries of Asia have
long been acquainted with the seeds of certain trees of the tribe
_Pangieæ_ (ord. _Bixineæ_) as a remedy for maladies of the skin. In
China a seed called _Ta-fung-tsze_ is imported from Siam[321] where it
is known as _Lukrabo_ and used in a variety of cutaneous complaints.
The tree affording it, which is figured in the _Pun-tasao_ (_circa_
A.D. 1596) has not been recognised by botanists, but from the structure
of the seed it is obviously closely related to _Gynocardia_.[322]

[319] Gmelin, _Chemistry_, xiv. (1860) 210.

[320] Fig. in Bentley and Trimen, _Medic. Plants_, part. 26 (1877).
Also in Christy, _New Commercial Plants_, No. 2 (1878).

[321] The _Commercial Report from H. M. Consul-General in Siam for the
year 1871_, presented to Parliament, Aug. 1872, states that 48 peculs
(6400 lb.) of _Lukrabow seeds_ were exported from Bangkok to China in
1871. Sir Joseph Hooker (_Report on the Royal Gardens at Kew_, 1877,
p. 33) has been informed by Mr. Pierre, the director of the Botanic
Garden at Saigon, Cochin China, that the seeds have proved to derive
from a Hydnocarpus (Gynocardia).—See also our article Semen Ignatii and
_Science Papers_, p. 235.

[322] Hanbury, _Notes on Chinese Mat. Med._ (1862) 23.—_Science
Papers_, 244. Dr. Porter Smith assumes the Chinese drug to be derived
from _G. odorata_, but as I have pointed out, the seeds have a much
stronger testa than those of that tree.—D. H.

The properties of _G. odorata_ were known to Roxburgh who, Latinizing
the Indian name of the tree, called it (1814) _Chaulmoogra odorata_. Of
late years the seeds have attracted the notice of Europeans in India,
and having been found useful in certain skin diseases, they have been
admitted a place in the _Pharmacopœia of India_.

=Description=—The seeds, 1 to 1¼ inches long and about half as much
in diameter, are of irregular ovoid form, and more or less angular or
flattened by mutual pressure; they weigh on an average about 35 grains
each. The testa is thin (about ¹/₅₀ of an inch), brittle, smooth, dull
grey; within there is a brown oily kernel, marked with a darker colour
at its basal end. The weight of the kernel is, on an average, twice
that of the testa. The former encloses in its copious, soft albumen
a pair of large, plain, leafy, heart-shaped cotyledons with a stout
radicle. The taste of the kernel is simply oily.

=Microscopic Structure=—The testa is chiefly formed of cylindrical
thick-walled cells. The albumen exhibits large angular cells containing
fatty oil, masses of albuminous matter and tufted crystals of calcium
oxalate. Starch is not present.

=Chemical Composition=—The kernels afforded us by means of ether 51·5
per cent. of fatty oil, which is almost colourless or somewhat brownish
if the seeds are not fresh. Either extracted or expressed it is of no
peculiar taste. The pressed oil concretes at 17° C.; that extracted
by ether or bisulphide of carbon requires for solidification a lower
temperature. The expressed oil is slightly fluorescent, less so that
extracted by means of bisulphide of carbon. If the oil, either pressed
or extracted, is diluted with the bisulphide, and then concentrated
sulphuric or nitric acid is added, no peculiar coloration is produced.

From the powdered kernels deprived of oil, water removes the usual
constituents, glucose, mucilage and albumin.

=Uses=—The seeds are said to have been advantageously used as an
alternative tonic in scrofula, skin diseases and rheumatism. They
should be freed from the testa, powdered, and given in the dose of 6
grains gradually increased. Reduced to a paste and mixed with Simple
Ointment, they constitute the _Unguentum Gynocardiæ_ of the _Indian
Pharmacopœia_, which, as well as an expressed oil of the seeds may be
employed externally in herpes, tinea, &c.[323]

[323] For particulars see Christy’s pamphlet alluded to above, p. 75.

=Substitute=—It has been suggested that the seeds of _Hydnocarpus
Wightiana_ Bl., a tree of Western India, and of _H. venenata_ Gärtn.,
native of Ceylon, might be tried where those of _Gynocardia_ are not
procurable. The seeds of both species of _Hydnocarpus_ (formerly
confounded together as _H. inebrians_ Vahl) afford a fatty oil which
the natives use in cutaneous diseases.[324]




POLYGALEÆ.


RADIX SENEGÆ.

_Radix Senekæ_; _Senega or Seneka Root_; F. _Racine de Polygala de
Virginie_; G. _Senegawurzel_.

=Botanical Origin=—_Polygala Senega_ L., a perennial plant with slender
ascending stems 6 to 12 inches high, and spikes of dull white flowers
resembling in form those of the Common Milkwort of Britain. It is found
in British America as far north as the river Saskatchewan, and in the
United States from New England to Wisconsin, Kentucky, Tennessee,
Virginia and the upper parts of North Carolina, as well as in Georgia
and Texas, not in the Rocky Mountains.

The plant, which frequents rocky open woods and plains, has become
somewhat scarce in the Atlantic states, and as a drug is now chiefly
collected in the west, the plant growing profusely in Iowa and
Minnesota, west of New York.

=History=—The employment of this root among the Seneca Indians as a
remedy for the bite of the rattlesnake attracted the notice of Tennent,
a Scotch physician in Virginia; and from the good effects he witnessed
he concluded that it might be administered with advantage in pleurisy
and peripneumonia. The result of numerous trials made in the years
1734 and 1735 proved the utility of the drug in these complaints, and
Tennent communicated his observations to the celebrated Dr. Mead of
London in the form of an epistle, afterwards published together with an
engraving of the plant, then called the _Seneca Rattlesnake Root_.[325]
Tennent’s practice was to administer the root in powder or as a strong
decoction, or more often infused in wine. The new drug was favourably
received in Europe, and its virtues discussed in numerous theses and
dissertations, one written in 1749 being by Linnæus.[326]

=Description=—Senega root is developed at its upper end into a knotty
crown, in old roots as much as an inch in diameter, from which
spring the numerous wiry aerial stems, beset at the base with scaly
rudimentary leaves often of a purplish hue. Below the crown is a simple
tap-root ²/₁₀ to ³/₁₀ of an inch thick, of contorted or somewhat spiral
form, which usually soon divides into 2 or 3 spreading branches and
smaller filiform rootlets.

[324] Waring, _Pharm. of India_, 1868. 27.

[325] Tennent (John), _Epistle to Dr. Richard Mead concerning the
epidemical diseases of Virginia_, &c., Edinb. 1738.

[326] _Amœnitates Academicæ_, ii. 126.

The bark is light yellowish-grey, translucent, horny, shrivelled,
knotted and partially annulated. Very frequently a keel-shaped ridge
occurs, running like a shrunken sinew through the principal root;
it has no connexion with the wood, but originates in a one-sided
development of the liber-tissue. The bark encloses a pure, white woody
column about as thick as itself. After the root has been macerated in
water the bark is easily peeled off, and the peculiar structure of
the wood can then be studied. The latter immediately below the crown
is a cylindrical cord, cleft however by numerous, fine, longitudinal
fissures. Lower down these fissures increase in an irregular manner,
causing a very abnormal development of the wood. Transverse sections
of a root therefore differ greatly, the circular wood portion being
either penetrated by clefts or wide notches, or one-half or even more
is altogether wanting, the space where wood should exist being in each
case filled up by uniform parenchymatous tissue.

Senega root has a short brittle fracture, a peculiar rancid odour, and
a very acrid and sourish taste. When handled it disperses in irritating
dust.

=Microscopic Structure=—The woody part is built up of dotted vessels
surrounded by short porous ligneous cells; the medullary rays consist
of one or two rows of the usual small cells. There is no pith in the
centre of the root. The clefts and notches are filled up with an
uniform tissue passing into the primary cortical tissue without a
distinct liber; the large cells of this tissue are spirally striated.
In the keel-shaped rider the proper liber rays may be distinguished
from the medullary rays. The former are made up of a soft tissue, hence
the cortical part of the root breaks short together with the wood.

Neither starch granules nor crystals of oxalate of calcium are present
in this root; the chief contents of its tissue are albuminoid granules
and drops of fatty oil.

=Chemical Composition=—The substance to which the drug owes its
irritating taste was distinguished by the name of _Senegin_ by Gehlen
as early as 1804, and is probably the same as the _Polygalic Acid_ of
Quevenne (1836) and of Procter (1859). Christophsohn (1874) extracted
it by means of boiling water, evaporated the solution and exhausted
the residue with boiling alcohol (0·853 sp. gr.). The liquid after a
day or two, deposits the crude senegin, which is to be washed with
alcohol (0·813 sp. gr.), and again dissolved in water, from which it
is precipitated by a large excess of hydrate of baryum. The barytic
compound, dissolved in water, is decomposed by carbonic acid, by which
carbonate of baryum is separated, senegin remaining in solution. It
is lastly to be precipitated by alcohol. It is amorphous, insoluble
in ether and in cold water; it forms with boiling water a frothing
solution. Like saponin, to which it is very closely allied, it excites
violent sneezing.

Dilute inorganic acids added to a warm solution of senegin throw down
a flocculent jelly of _Sapogenin_, the liquid retaining in solution
uncrystallizable sugar. Alkalis give rise to the same decomposition;
but it is difficult to split up the senegin completely, and hence the
formulas given for this process are doubtful. Even the formula of
senegin itself is not definitely settled. According to Christophsohn,
the root yields about 2 per cent. of this substance; according to
earlier authorities, who doubtless had it less pure, a much larger
proportion. From Schneider’s investigations (1875) it would appear that
the rootlets are richest in senegin.

Senega root contains a little volatile oil, traces of resin, also gum,
salts of malic acid, yellow colouring matter, and sugar (7 per cent.
according to Rebling, 1855). The _Virginic Acid_ said by Quevenne to
be contained in it, and the bitter substance _Isolusin_ mentioned by
Peschier, are doubtful bodies.

=Uses=—Senega is prescribed as a stimulating expectorant and diuretic,
useful in pneumonia, asthma and rheumatism. It is much esteemed in
America.

=Adulteration=—The drug is not liable to be wilfully falsified, but
through careless collecting there is occasionally a slight admixture of
other roots. One of these is American Ginseng (_Panax quinquefolium_
L.) a spindle-shaped root which may be found here and there both in
senega and serpentaria. The rhizome of _Cypripedium pubescens_ Willd.
has also been noticed; it cannot be confounded with that of _Polygala
Senega_. The same may be said with regard to the rhizome of _Cynanchum
Vincetoxicum_ R. Brown (_Asclepias_ L., _Vincetoxicum officinale_
Mönch).


RADIX KRAMERIÆ.

_Radix Ratanhiæ_, _Rhatanhiæ v. Rathaniæ_; _Rhatany or Rhatania
Root, Peruvian or Payta Rhatany_; F. _Racine de Ratanhia_; G.
_Ratanhiawurzel_.[327]

=Botanical Origin=—_Krameriæ triandra_ Ruiz et Pav., a small woody
shrub with an upright stem scarcely a foot high and thick decumbent
branches 2 to 3 feet long.[328] It delights in the barren sandy
declivities of the Bolivian and Peruvian Cordilleras at 3000 to 8000
feet above the sea-level, often occurring in great abundance and
adorning the ground with its red star-like flowers and silver-grey
foliage.

The root is gathered chiefly to the north, north-east, and east of
Lima, as at Caxatambo, Huanuco, Tarma, Jauja, Huarochiri and Canta;
occasionally on the high lands about lake Titicaca. It appears likewise
to be collected in the northern part of Peru, since the drug is now
frequently shipped from Payta.

=History=—Hipolito Ruiz,[329] the Spanish botanist, observed in 1784
that the women of Huanuco and Lima were in the habit of using for the
preservation of their teeth a root which he recognized as that of
_Krameria triandra_, a plant discovered by himself in 1779. On his
return to Europe he obtained admission for this root into Spain in
1796, whence it was gradually introduced into other countries of Europe.

The first supplies which reached England formed part of the cargo
of a Spanish prize, and were sold in the London drug sales at the
commencement of the present century. Some fell into the hands of Dr.
Reece who recommended it to the profession.[330]

About 20 years ago there appeared in the European market some other
kinds of rhatany previously unknown: of these the more important are
noticed at pp. 81, 82.

[327] Ruiz and Pavon state that the root is called at Huanuco
_ratanhia_. The derivation of the word which is of the Quichua language
is obscure.

[328] Fig. in Bentley and Trimen, _Medicinal Plants_, part 30 (1876).

[329] _Mem. de la R. Acad. med. de Madrid_, i. (1797) 349—366.

[330] _Medicinal and Chirurgical Review_, Lond., xiii. (1806) ccxlvi.;
also Reece, _Dict. of Domest. Med._, 1808.

=Description=—The root which attains a considerable size in proportion
to the aerial part of the shrub, consists of a short thick crown,
sometimes much knotted and as large as a man’s fist. This ramifies
beneath the soil even more than above, throwing out an abundance of
branching, woody roots (frequently horizontal) some feet long and ¼
to ½ an inch thick. These long roots used formerly to be found in
commerce; but of late years rhatany has consisted in large proportion
of the more woody central part of the root with short stumpy branches,
which from their broken and bruised appearance have evidently been
extracted with difficulty from a hard soil.

The bark which is scaly and rugged, and ⅒ to ¹/₂₀ of an inch in
thickness, is of a dark reddish-brown. It consists of a loose cracked
cork-layer, mostly smooth in the smaller roots, covering a bright
brown-red inner bark, which adheres though not very firmly to a
brownish yellow wood. The bark is rather tough, breaking with a fibrous
fracture. The wood is dense, without pith, but marked with thin vessels
arranged in concentric rings, and with still thinner, dark medullary
rays. The taste of the bark is purely astringent; the wood is almost
tasteless; neither possesses any distinctive odour.

_Kr. cistoidea_ Hook, a plant scarcely to be distinguished from _Kr.
triandra_, affords in Chili a rhatany very much like that of Peru. Its
root was contributed to the Paris Exhibition of 1867.

=Microscopic Structure=—The chief portion of the bark is formed of
liber, which in transverse section exhibits numerous bundles of yellow
fibres separated by parenchymatous tissue and traversed by narrow brown
medullary rays. The small layer of the primary bark is made up of large
cells, the surface of the root of large suberous cells imbued with red
matter. The latter also occurs in the inner cortical tissue, and ought
to be removed by means of ammonia in order to get a clear idea of the
structure. Many of the parenchymatous cells are loaded with starch
granules; oxalate of calcium occurs in the neighbourhood of the liber
bundles. The woody portion exhibits no structure of particular interest.

=Chemical Composition=—Wittstein (1854) found in the bark of rhatany
(the only part of the drug having active properties) about 20 per cent.
of a form of tannin called _Ratanhia-tannic Acid_, closely related to
catechu-tannic acid. It is an amorphous powder, the solution of which
is not affected by emetic tartar, but yields with ferric chloride a
dark greenish precipitate. By distillation Eissfeldt (1854) obtained
pyrocatechin as a product of the decomposition of ratanhia-tannic acid.
The latter is also decomposed by dilute acids which convert it into
crystallizable sugar and _Ratanhia-red_, a substance nearly insoluble
in water, also occurring in abundance ready formed in the bark.

Grabowski (1867) showed that by fusing ratanhia-red with caustic
potash, protocatechuic acid and phloroglucin[331] are obtained.
Ratanhia-red has the composition C₂₆H₂₂O₁₁, the same, according
to Grabowski, as an analogous product of the decomposition of the
peculiar tannic acid occurring (as shown by Rochleder in 1866) in
the horse-chestnut. The same red substance may also be obtained, as
stated by Rembold (1868), from the tannic acid of the root of tormentil
(_Potentilla Tormentilla_ L.).

[331] See art. Kino.

As to rhatany root, Wittstein also found it to contain wax, gum and
uncrystallizable sugar (even in the wood! according to Cotton[332]).
Cotton further pointed out the presence in very minute quantity of
an odorous, volatile, solid body, obtainable by means of ether or
bisulphide of carbon; it occurs in a somewhat more considerable amount
in the other sorts of rhatany. The root contains no gallic acid.

A dry extract of rhatany resembling kino used formerly to be imported
from South America, but how and where manufactured we know not. It
is however of some interest as containing a crystalline body which
Wittstein who discovered it (1854) regards as _Tyrosin_, C₉H₁₁O₃,
previously supposed to be exclusively of animal origin.[333] Städeler
and Ruge (1862) assigned to it a slightly different composition,
C₁₀H₁₃NO₃, and gave it the name of _Ratanhin_. It dissolves in hot
water which is acidulated by a little nitric acid; the solution on
boiling turns red, blue, and lastly green, and becomes at the same
time fluorescent. Kreitmair (1875) extracted 0·7 per cent, of ratanhin
from an old specimen of commercial extract of rhatany; but he did not
succeed in obtaining it from other specimens. He also showed that
ratanhin is _not_ a constituent of the roots of Krameria. The same
substance has been abundantly found by Gintl (1868) in the natural
exudation called _Resina d’Angelim pedra_[334] which is met with in the
alburnum of _Ferreirea spectabilis_ Allem., a large Brazilian tree of
the order _Leguminosæ_ (tribe _Sophoreæ_). Peckolt, who first extracted
it, named it _Angelin_; it forms colourless, neutral crystals yielding
compounds both with alkalis and acids, which have been investigated by
Gintl in 1869 and 1870.

=Uses=—Rhatany is a valuable astringent, but is not much employed in
Great Britain.

=Other sorts of Rhatany=—Of the 20 to 25 other species of _Krameria_,
all of them belonging to America, several have astringent roots which
have been collected and used in the place of the rhatany of Peru. The
most important of these drugs is that known as—

_=Para Rhatany=_,—so called from having been shipped from Pará in
Brazil. Berg who described it in 1865 termed it _Brazilian Rhatany_,
Cotton in 1868, _Ratanhia des Antilles_. It is a drug nearly resembling
the following, but of a darker and less purple hue; it is also in
longer sticks which are remarkably flexible, and covered with a thick
bark having numerous transverse cracks.[335] It is apparently derived
from the _Krameria argentea_ of Martius,[336] the root of which is
collected in the dry districts of the provinces of Bahia and Minas
Geraes, that plant growing throughout north-eastern Brazil. It is also
called _Rhatany from Ceará_.

[332] _Etudes sur le Genre Krameria_ (thèse), Paris, 1868. 83.

[333] Gmelin, _Chemistry_, xiii. (1859) 358.

[334] See Vogl’s Paper on it in Pringsheim, _Jahrbücher für
wissenschaftliche Botanik_, ix. (1874) 277-285.

[335] For further particulars, see Flückiger, _Pharm. Journ._, July 30,
1870. 84.

[336] _Syst. Mat. Med. Bras._, 1843. 51; Langgaard, _Diccionario de
Medicina_, Rio de Janeiro, iii. (1865) 384.—Krameria argentea is
figured in _Flora Brasiliensis_, Fascicul. 63 (1874, pg. 71) tab. 28.

_=Savanilla or New Granada Rhatany.=_ The plant yielding it is
_Krameria tomentosa_ St. Hil. (_Kr. Ixina_ var. β _granatensis_ Triana,
_Kr. grandifolia_ Berg), a shrub 4 to 6 feet high covering large arid
tracts in the valley of Jiron between Pamplona and the Magdalena in
New Granada, in which locality the collection of the root was observed
by Weir in 1864.[337] According to Triana it also grows at Socorro,
south of Jiron. The same plant is found near Santa Marta and Rio Hacha
in north-eastern New Granada, in British Guiana, and in the Brazilian
provinces of Pernambuco and Goyaz.

The stem or root-crown of Savanilla rhatany is never so knotty and
irregular as that of the Peruvian drug, nor are the roots so long or so
thick. Separate pieces of root of sinuous form, 4 to 6 inches long and
²/₁₀ to ³/₁₀ of an inch thick are most frequent. The drug is moreover
well distinguished by its dull purplish brown colour, its thick smooth
bark marked with longitudinal furrows, and here and there with deep
transverse cracks, and by the bark not easily splitting off as it does
in common rhatany.

The anatomical difference depends chiefly upon the more abundant
development of the bark which in thickness is ⅓ to ¼ the diameter of
the wood. In Peruvian rhatany the cortical layer attains only ⅙ to ⅛ of
the diameter of the woody column. The greater firmness of the suberous
coat in Savanilla rhatany is due to its cells being densely filled with
colouring matter.

Savanilla rhatany differs from the Peruvian root in its tannic matter.
This becomes evident by shaking the powdered root (or bark) with water
and iron reduced by hydrogen. The liquid filtered from the Savanilla
sort and diluted with distilled water exhibits an intense violet
colour, that from Peruvian rhatany a dingy brown; the latter turns
light red by alkalis. Thin sections of the Peruvian root assume a
greyish hue when moistened with a ferrous salt; Savanilla root by a
similar treatment displays the above violet colour. The Savanilla root
is richer in soluble matter and from the greater development of its
bark may deserve to be preferred for medicinal use.

In the English market, Savanilla root is of less frequent occurrence
than that of Pará.

A kind of rhatany attributed to _Krameria secundiflora_ DC., a
herbaceous plant of Mexico, Texas and Arkansas, was furnished to Berg
in 1854, but has not been in commerce. Its anatomical structure has
been described by Berg.[338]

[337] Hanbury, _Origin of Savanilla Rhatany_, in _Pharm. Journ._ vi.
(1865) 460.—Also _Science Papers_, 333.—In that paper I referred the
drug to a variety of _Kr. Ixina_ which M. Cotton has shown to differ in
no respect from St. Hilaire’s _Kr. tomentosa_, a conclusion in which,
after careful re-examination of specimens, I fully agree.—D. H.

Fig. of _Kr. Ixina_ in Bentley and Trimen, _Med. Pl._ part 10.

[338] _Bot. Zeitung_, 14th Nov. 1856. 797




GUTTIFERÆ.


=CAMBOGIA.=

_Gummi Gambogia_, _Gummi Gutti_; _Gamboge_; F. _Gomme Gutte_; _G.
Gutti_, _Gummigutt_.

=Botanical Origin=—_Garcinia Morella_ Desrousseaux, var. β.
_pedicellata_, a diœcious tree,[339] with handsome laurel-like foliage
and small yellow flowers, found in Camboja, Siam (province of Chantibun
and the islands on the east coast of the gulf of Siam), and in the
southern parts of Cochin China. It was introduced about thirty years
ago into Singapore where several specimens are still thriving (1873) on
the estate of Dr. Jamie. The finest is now a tree of 20 feet high, with
a trunk a foot in diameter, and a thick, spreading head of foliage.

_G. Morella_ Desr.—The typical form of this tree having _sessile_ male
flowers grows in moist forests of Southern India and Ceylon, and is
capable of affording good gamboge.

_G. pictoria_ Roxb., a large tree of Southern India, produces a sort of
gamboge found by Christian (1846) essentially the same as that of Siam.
It has been examined more recently by Broughton (1871) who states it
to be quite equal to that of _G. Morella_. We have also been unable to
find any difference between the product of _G. pictoria_ as sent from
Ceylon and common gamboge. _Garcinia pictoria_ moreover is thought by
Sir Jos. Hooker to agree with _G. Morella_.

=History=—The Chinese had intercourse with Camboja as early as the
time of the Sung dynasty (A.D. 970-1127); and a Chinese traveller
who visited the latter country in 1295-97, describes gamboge and the
method of obtaining it by incisions in the stem of the tree.[340] The
celebrated Chinese herbal _Pun-tsao_, written towards the close of the
16th century, mentions gamboge (_Tang-hwang_) and gives a rude figure
of the tree. The drug is regarded by the Chinese as poisonous, and is
scarcely employed except as a pigment.

The first notice of the occurrence of gamboge in Europe is in the
writings of Clusius[341] who describes a specimen brought from China
by the Dutch Admiral, Jacob van Neck, and given to him in 1603, under
the name of _Ghittaiemou_.[342] It appears that shortly after this
time it began to be employed in medicine in Europe, for in 1611,
Michael Reuden, a physician of Bamberg, made use of it as he stated in
1613.[343] He termed the drug a “novum gummi purgans,” or also, Gummi
de Peru, the latter strange name no doubt being a corruption of the
above mentioned Ghittaiemou. The appellation “gummi de Peru” is met
with in pharmaceutical tariffs during the 17th and 18th centuries.

[339] It has been named _Garcinia Hanburyi_ by Sir Joseph Hooker
(_Journ. of the Linnean Soc._ xiv., 1873, 435), but I presume my
lamented friend Daniel Hanbury would not have considered the plant
under notice as a distinct species. Consult also Bentley and Trimen,
_Med. Plants_, part 30.—F. A. F.

[340] _Description de Camboge_ in Abel-Remusat’s _Nouv. Mélanges
asiatiques_, i. (1829) 134.—The Chinese traveller calls the exudation
_Kiang-hwang_ which is the name for _turmeric_, but his description is
unmistakeable.

[341] _Exotica_ (1605) 82.

[342] Dr. R. Rost is of opinion that this word is derived from the
Malay _gătáh_, gum, and the Javanese _jamú_ signifying medicinal, such
mixing of the two languages being of common occurrence.

[343] _De nova gummi purgante_, Lipsiæ, 1614. We have only seen the
second edition published at Leiden in 1625, its preface dating from
1613.

Gamboge is one of the articles of the tariff of the pharmaceutical
shops of the City of Frankfort in 1612: “Gutta gemou, a strong
purgative dried juice, coming from the Kingdom of _Patana_ in the
East Indies.” Patana or Patani is the most populous province of the
east coast of the peninsula of Malacca. The Dutch established there
a factory in 1602, and were followed in 1612 by the English. The
settlement was abandoned in 1700; gamboge was probably brought there
from the opposite shore of the gulf of Siam.[344]

In 1615, a considerable quantity of gamboge was offered for sale in
London by the East Indian Company. The entry respecting it in the Court
Minute Books of the company under date October 13, 1615, is to this
effect:—Three chests, one rundlet, and a basket, containing 13, 14,
or 15 hundredweights, more or less, of _Cambogium_ “_a drugge unknown
here_,”—the use of which, was much commended as a “_a gentle purge_,”
were offered for sale at 5s. per lb., but met with no purchaser.

Jacob Bontius,[345] a Dutch physician, resident, towards 1629, in
Batavia, stated that “gutta Cambodja,” as he termed the drug, came from
the country of the same name; he supposed it to be derived from an
Euphorbiaceous plant.

Parkinson,[346] who was an apothecary of London and wrote in 1640,
speaks of this “_Cambugio_,” called by some _Catharticum aureum_, as a
drug of recent importation which arrived in the form of “_wreathes or
roules_” yellow within and without.

In the _London Pharmacopœia_ of 1650, gamboge is called _Gutta
Gamba_[347] or _Ghitta jemou_.

The mother plant of the drug was not fully examined and figured until
1864; yet in 1677 already, Hermann, a German physician residing in
Ceylon, had pointed out that it was a Garcinia.[348]

=Secretion=—We have examined a portion of a branch two inches in
diameter of the gamboge-tree,[349] and have found the yellow gum-resin
to be contained chiefly in the middle layer of the bark in numerous
ducts like those occurring in the roots of _Inula Helenium_ and other
roots of the same natural order. A little is also secreted in the
dotted vessels of the outermost layer of the wood, and in the pith. The
wood, which is white, acquires a bright yellow tint when exposed to the
vapour of ammonia or to alkaline solutions.

=Production=—At the commencement of the rainy season the
gamboge-collectors start for the forest in search of the trees which
in some localities are plentiful. Having found one of the full size
they make a spiral incision in the bark round half the circumference of
the trunk, and place a joint of bamboo to receive the sap which slowly
exudes for several months. When it first issues from the tree, it is
a yellowish fluid, which after passing through a viscid state hardens
into the gamboge of commerce.

[344] Flückiger, _Documente zur Geschichte der Pharmacie_, 1876. 41.

[345] _De Medicina Indorum_, lib. iv. Lugduni Batav. (1642) 119. 150.

[346] _Theatrum Botanicum_ (1640) 1575.

[347] This name is the Hindustani _Gótáganbá_, signifying according to
Moodeen Sheriff (_Suppl. to Pharm. of India_, 83) _juice or extract of
rhubarb_. It is still applied to gamboge.

[348] Hanbury in _Trans. of Linn. Soc._ xxiv. (1864) 487. tab. 50; also
_Science Papers_, 1876. 326.

[349] Obligingly sent to us by Dr. Jamie of Singapore.

The trees grow both in the valleys and on the mountains and will yield
on an average in one season enough to fill three joints of bamboo 20
inches in length by 1½ inches in diameter. The tree appears to suffer
no injury provided the tapping is not more frequent than every other
year.[350]

According to Dr. Jamie of Singapore, the gamboge-tree grows most
luxuriantly in the dense jungles. The best time for collecting is from
February to March or April. The trees, the larger the better, are
wounded by a parang or chopping-knife, in various parts of the trunk
and large branches, when prepared bamboos are inserted between the
root and the bark of the trees. The bamboo cylinders being tied or
inserted, are examined daily till filled, which generally takes from 15
to 30 days. Then the bamboos are taken to a fire, over which they are
gradually rotated till the water in the gum-resin is evaporated and it
gets sufficiently hard to allow of the bamboo being torn off.[351]

=Description=—The drug arrives in the form of sticks or cylinders 1 to
2½ inches in diameter, and 4 to 8 inches in length, striated lengthwise
with impressions from the inside of the bamboo. Often the sticks are
agglutinated, or folded, or the drug is in compressed or in shapeless
masses. It is when good of a rich brownish orange tint, dense and
homogeneous, breaking easily with a conchoidal fracture, scarcely
translucent even in thin splinters. Touched with water it instantly
forms a yellow emulsion. Triturated in a mortar it affords a brilliant
yellow powder, slightly odorous. Gamboge has a disagreeable acrid taste.

Much of the gamboge shipped to Europe is of inferior quality, being
of a brownish hue or exhibiting when broken a rough, granular, bubbly
surface. Sometimes it arrives imperfectly dried and still soft.

=Chemical Composition=—Gamboge consists of a mixture of resin with
15 to 20 per cent. of gum. The resin dissolves easily in alcohol,
forming a clear liquid of fine yellowish-red hue, and not decidedly
acid reaction. It forms darker-coloured solutions with ammonia or the
fixed alkalis, and a copious precipitate with basic acetate of lead.
Perchloride of iron colours a solution of the resin deep blackish brown.

By fusing purified gamboge resin with potash, Hlasiwetz and Barth
(1866) obtained acetic acid and other acids of the same series,
together with _phloroglucin_, C₆H₃(OH)₃, _pyrotartaric_ acid, C₅H₈O₄,
and _isuvitinic_ acid, C₆H₃CH₃(COOH)₂.

The gum which we obtained to the extent of 15·8 per cent. by completely
exhausting gamboge with alcohol and ether, was found readily soluble in
water. The solution does not redden litmus, and is not precipitated by
neutral acetate of lead, nor by perchloride of iron, nor by silicate or
biborate of sodium. It is therefore not identical with gum arabic.

[350] Spenser St. John, _Life in the Forests of the Far East_, Lond.
1862. ii. 272.

[351] _Pharm. Journ._ iv. (1874) 803.

=Commerce=—The drug finds its way to Europe from Camboja by Singapore,
Bangkok, or Saigon. In 1877 the first place exported 240 peculs,
Bangkok in 1875 no less than 346 peculs, value 48,835 dollars; from
Saigon there have of late been shipped from 30 to 40 peculs annually
(one pecul = 133·3 lbs. = 60·479 kilogrammes).[352]

=Uses=—Gamboge is a drastic purgative, seldom administered except in
combination with other substances.

=Adulteration=—The Cambojans adulterate gamboge with rice flour, sand,
or the pulverized bark of the tree,[353] which substances may be easily
detected in the residue left after exhausting the drug successively by
spirit of wine and cold water.

=Other Sources of Gamboge=—Although the gamboge of European commerce
appears to be exclusively derived from the form of the plant named at
the head of this article, _Garcinia travancorica_ Beddome, is capable
of yielding a similar drug which may be collected to some small extent
for local use, but not for exportation. It is a beautiful tree of the
southern forests of Travancore and the Tinnevelly Ghats (3,000 to 4,500
feet). According to its discoverer Lieut. Beddome,[354] it yields an
abundance of bright yellow gamboge.


OLEUM GARCINIÆ.

_Concrete Oil of Mangosteen_, _Kokum Butter_.

=Botanical Origin.=—_Garcinia indica_ Choisy (_G. purpurea_ Roxb.
_Brindonia indica_ Dup. Th.), an elegant tree with drooping branches
and dark green leaves.[355] It bears a smooth round fruit the size of a
small apple, containing an acid purple pulp in which are lodged as many
as 8 seeds. The tree is a native of the coast region of Western India
known as the Concan, lying between Daman and Goa.

=History=—The fruit is mentioned by Garcia d’Orta(1563) as known to
the Portuguese of Goa by the name of _Brindones_. He states that it
has a pleasant taste though very sour, and that it is used in dyeing;
and further that the peel serves to make a sort of vinegar. Several
succeeding authors (as Bauchin and Ray) have contented themselves with
repeating this account.

As to the fruit yielding a fatty oil, we find no reference to such
fact till about the year 1830, when it was stated in an Indian
newspaper[356] that an oil of the seeds is well known at Goa and often
used to adulterate ghee (liquid butter). It was afterwards pointed out
as the result of some experiments that the oil was of an agreeable
bland taste and well adapted for use in pharmacy. A short article on
Kokum Butter was published by Pereira[357] in 1851. With the view of
bringing the substance into use for pharmaceutical preparations in
India, it has been introduced into the _Pharmacopœia of India_ of 1868.

[352] _Report from H. M. Consul-General in Siam for 1875_. 9.

[353] Spenser St. John, _op. cit._

[354] _Flora Sylvatica_, Madras, part xv. (1872) tab. 173.

[355] Fig. Bentley and Trimen, _Medic. Plants_, part 31 (1878).

[356] Quoted by Graham, _Catal. of Bombay Plants_, 1839. 25.

[357] _Pharm. Journ._ xi. (1852) 65.

=Preparation=—The seeds are reniform, somewhat crescent-shaped or
oblong, laterally compressed and wrinkled, ⁶/₁₀ to ⁸/₁₀ of an inch
long by about ⁴/₁₀ broad. Each seed weighs on an average about eight
grains. The thick cotyledons, which are inseparable,[358] have a mild
oily taste. Examination under the microscope shows them to be built
up of large reticulated cells containing a considerable proportion of
crystalline fat readily soluble in benzol. In addition globular masses
of albuminous matter occur which with iodine assume a brownish yellow
hue. With perchloride of iron the walls strike a greenish-black.

The process followed by the natives of India (by whom alone the oil
is prepared) has been thus described:—The seeds having been dried by
exposure for some days to the sun are bruised, and boiled in water. The
oil collects on the surface, and concretes when cool into a cake which
requires to be purified by melting and straining.

=Description=—Kokum Butter is found in the Indian bazaars in the form
of egg-shaped or oblong lumps about 4 inches long by 2 inches in
diameter, and weighing about a quarter of a pound. It is a whitish
substance, at ordinary temperatures, firm, dry, and friable, yet greasy
to the touch. Scrapings (which are even pulverulent) when examined in
glycerin under the microscope show it to be thoroughly crystalline.
They have a mild oily taste, yet redden litmus if moistened with
alcohol.

By filtration in a steam-bath, kokum butter is obtained perfectly
transparent and of a light straw-colour, concentrating again at 27·5°
C. into a white crystalline mass: some crystals appear even at 30°.
Melted in a narrow tube, cooled and then warmed in a water bath, the
fat begins to melt at 42·5 C., and fuses entirely at 45°. The residue
left after filtration of the crude fat is inconsiderable, and consists
chiefly of brown tannic matters soluble in spirit of wine.

When kokum butter is long kept it acquires an unpleasant rancid smell
and brownish hue, and an efflorescence of shining tufted crystals
appears on the surface of the mass.

=Chemical Composition=—Purified kokum butter boiled with caustic soda
yields a fine hard soap which, when decomposed with sulphuric acid,
affords a crystalline cake of fatty acids weighing as much as the
original fat. The acids were again combined with soda and the soap
having been decomposed, they were dissolved in alcohol of about 94
per cent. By slow cooling and evaporation crystals were first formed
which, when perfectly dried, melted at 69·5° C.: they are consequently
_Stearic Acid_. A less considerable amount of crystals which separated
subsequently had a fusing point of 55°, and may be referred to
_Myristic Acid_.

A portion of the crude fat was heated with oxide of lead and water,
and the plumbic compound dried and exhausted with ether, which after
evaporation left a very small amount of liquid oil, which we refer to
_Oleic Acid_.

Finally the sulphuric acid used at the outset of the experiments was
saturated and examined in the usual manner for volatile fatty acids
(butyric, valerianic, &c.) but with negative results.

[358] The embryo, according to Bentley and Trimen (_l. c._) consists
chiefly of the _thickened_ radicle, and is almost devoid of cotyledons.

The fat of the seeds of _G. indica_ was extracted by ether and examined
chemically in 1857 by J. Bouis and d’Oliveira Pimentel.[359] It was
obtained to the extent of 30 per cent., was found to fuse at 40° C. and
to consist chiefly of stearin (tristearin). The seeds yielded 1·72 per
cent. of nitrogen. Their residue after exhaustion by ether afforded to
alkaline solutions or alcohol a fine red colour.

=Uses=—The results of the experiments above-noted show that kokum
butter is well suited for some pharmaceutical preparations. It might
also be advantageously employed in candle-making, as it yields stearic
acid more easily and in a purer state than tallow and most other fats.
But that it is possible to obtain it in quantities sufficiently large
for important industrial uses, appears to us very problematical.




DIPTEROCARPEÆ.


=BALSAMUM DIPTEROCARPI.=

_Balsamun Gurjunæ; Gurjun Balsam, Wood Oil._

=Botanical Origin=—This drug is yielded by several trees of the genus
_Dipterocarpus_, namely—

_D. turbinatus_ Gärtn. f. (_D. lævis_ Ham., _D. indicus_ Bedd), a
native of Eastern Bengal, Chittagong and Pegu to Singapore, and French
Cochin China.

_D. incanus_ Roxb., a tree of Chittagong and Pegu.

_D. alatus_ Roxb., growing in Chittagong, Burma, Tenasserim, the
Andaman Islands, Siam, and French Cochin China.

_D. zeylanicus_ Thw. and _D. hispidus_ Thw., indigenous to Ceylon.

_D. crispalatus_ ... abounding, together with _D. turbinatus_ and _D.
alatus_, in French Cochin China.

_D. trinervis_ Bl., a native of Java and the Philippines, and _D.
gracilis_ Bl., _D. littoralis_ Bl., _D. retusus_ Bl. (_D. Spanoghei_
Bl.), trees of Java supply a similar useful product which as yet
appears to be of less commercial importance.[360]

The Gurjun trees are said by Hooker[361] to be among the most
magnificent of the forests of Chittagong. They are conspicuous for
their gigantic size, and for the straightness and graceful form of
their tall unbranched trunk, and small symmetrical crown of broad
glossy leaves. Many individuals are upwards of 200 feet high and 15
feet in girth.

=History=—Gurjun balsam was enumerated as one of the productions of
Ava by Francklin[362] in 1811, and in 1813 it was briefly noticed by
Ainslie.[363] Its botanical origin was first made known by Roxburgh,
who also described the method by which it is extracted.

[359] _Comptes Rendus_, xliv. (1857) 1355.

[360] That of _D. trinervis_ is especially used in Java. Filet,
_Plantkundig Woordenboek voor Nederlandsch Indië_, Leiden, 1876, No.
6157.

[361] _Himalayan Journal_, ed. 2, ii. (1855) 332.

[362] _Tracts on the Dominions of Ava_, Lond. 1811. 26.

[363] In the _Catalogue des Produits des_ _Colonies françaises,
Exposition Universelle de 1878_, p. 175, it is stated that the balsam
of _D. alatus_ in French Cochin China is preferred, being a “_huile
b’anche_.”

The medicinal properties of Gurjun balsam were pointed out by
O’Shaughnessy[364] as entirely analogous to those of copaiba; and his
observations were confirmed by many practitioners in India. This has
obtained for the drug a place in the _Pharmacopœia of India_ (1868).

=Extraction=—A recent account of the production of this drug is found
in the _Reports of the Jury of the Madras Exhibition of 1855_. It is
there stated that _Wood Oil_, as the balsam is commonly called, is
obtained for the most part from the coast of Burma and the Straits,
and is procured by tapping the trees about the end of the dry season.
Several deep incisions are made with an axe into the trunk of the
tree and a good-sized cavity scooped out. In this, fire is placed,
and kept burning until the wood is somewhat scorched, when the balsam
begins to exude, and is then led away into a vessel of bamboo. It is
afterwards allowed to settle, when a clear liquid separates from a
thick portion called the “_guad_.” The oil is extracted year after
year, and sometimes there are two or three holes in the same tree. It
is produced in extraordinary abundance; from 30 to 40 gallons according
to Roxburgh may sometimes be obtained from a single tree in the course
of a season, during which it is necessary to remove from time to time
the old charred surface of the wood and burn afresh.

If a growing tree is felled and cut into piece, the oleo-resin exudes
and concretes on the wood, very much, it is said, _resembling camphor_
(?) and having an aromatic smell.

=Description=—As Gurjun balsam is the produce of different trees as
well as of different countries, it is not surprising to find that it
varies considerably in its properties.

The following observations refer to a balsam of which 400 lb. were
recently imported from Moulmein for a London drug firm. It is a thick
and viscid fluid, exhibiting a remarkable fluorescence, so that when
seen by reflected light it appears opaque and of dingy greenish grey;
yet when placed between the observer and strong daylight it is seen to
be perfectly transparent and of a dark reddish-brown.[365] It has a
weak aromatic copaiba-like odour and a bitterish aromatic taste without
the persistent acridity of copaiba. Its sp. gr. at 16·9° C. is 0·964.

[364] _Mat. Med. of Hindoostan_, Madras, 1813. 186.

[365] _Bengal Dispensatory_, 1842. 22.

With the following liquids Gurjun affords perfectly clear solutions
which are more or less fluorescent, namely pure benzol (from benzoate
of calcium), cumol, chloroform, sulphide of carbon, essential oils. On
the other hand, it is not entirely soluble in methylic, ethylic, or
amylic alcohol; in ether, acetic ether, glacial acetic acid, acetone,
phenol (carbolic acid), or in caustic potash dissolved in absolute
alcohol. Many samples of commercial benzin also are not capable of
dissolving the oleo-resin perfectly, but we have not ascertained on
what constituent of such benzin this depends. We have further noticed
that that portion of petroleum which is known as _Petroleum Ether_,
containing the most volatile hydrocarbons, does not wholly dissolve the
oleo-resin. One hundred parts of the balsam warmed and shaken with
1000 parts of absolute alcohol yielded on cooling a precipitate of
resin amounting when dried to 18·5 parts. All concentrated solutions of
the balsam are precipitated by amylic alcohol.

If the balsam is kept for a long time in a stoppered vessel at 100° C.
it simply becomes a little turbid; but about 130° C. it is transformed
into a jelly, and on cooling does not resume its former fluidity.
Balsam of copaiba heated in a closed glass tube to 220° C. does not at
all lose its fluidity, whereas Gurjun balsam becomes an almost solid
mass.

=Chemical Composition=—Of the balsam 6·99 grammes dissolved in
benzol and kept in a water bath until the residue ceased to lose
weight, yielded 3·80 grammes of a dry, transparent, semi-fluid resin,
corresponding to 54·44 per cent., and 45·56 of volatile matters
expelled by evaporation. But another sample afforded us much less
residue. By submitting larger quantities of the above balsam to the
usual process of distillation with water in a large copper still, 37
per cent. of volatile oil were easily obtained. The water passing over
at the same time did not redden litmus paper. A dark, viscid, liquid
resin remained in the still.

The essential oil is of a pale straw-colour and less odorous than
most other volatile oils. Treated with chloride of calcium and again
distilled, it begins to boil at 210° C. and passes over at 255°-260°
C., acquiring a somewhat empyreumatic smell and light yellowish tint.
The purified oil has a sp. gr. of 0·915;[366] it is but sparingly
soluble in absolute alcohol or glacial acetic acid, but mixes readily
with amylic alcohol.

According to Werner (1862) this oil has the composition C₂₀H₃₂ like
that of copaiba. He says it deviates the ray of polarized light to the
left, but that prepared by one of us deviated strongly to the _right_,
the residual resin dissolved in benzol being wholly inactive. The
oil does not form a crystalline compound with dry hydrochloric acid,
which colours it of a beautiful blue.[367] De Vry[368] states that the
essential oil after this treatment deviates the ray to the right.

The resin contains, like that of copaiba, a small proportion of a
crystallizable acid which may be removed by warming it with ammonia
in weak alcohol. That part of the resin which is insoluble even in
absolute alcohol,[369] we found to be uncrystallizable. The _Gurgunic
Acid_, as the crystallized resinous acid is called by Werner,[370]
but which it is more correct to write _Gurjunic_, may consequently
be prepared by extracting the resin with alcohol (·838) and mixing
the solution with ammonia. From the ammoniacal solution gurjunic acid
is precipitated on addition of a mineral acid, and if it is again
dissolved in ether and alcohol it may be procured in the form of small
crystalline crusts. From the specimen under examination we were not
successful in obtaining indubitable crystals.

[366] 0·944 according to Werner; 0·931 O’Shaughnessy; 0·928 De Vry
(1857).

[367] This magnificent colouring matter is not dissolved by ether.

[368] _Pharm. Journ._ xvi. (1857) 374.

[369] The sample of gurjun balsam examined by Werner as well as the
resin it contained were entirely soluble in boiling potash lye.

[370] Gmelin, _Chemistry_, xvii. 545.

Gurjunic acid, C₄₄H₆₈O₈ according to Werner, melts at 220° C., and
concretes again at 180° C.; it begins to boil at 260° C., yet at the
same time decomposition takes place. By assigning to this acid the
formula C₄₄H₆₄O₅ + 3H₂O, which agrees well with Werner’s analytical
results, we may regard it as a hydrate of abietinic acid, the chemical
behaviour of which is perfectly analogous. Gurjunic acid is soluble in
alcohol 0·838, but not in weak alcohol; it is dissolved also by ether,
benzol, or sulphide of carbon (Werner).

In copaiba from Maracaibo, Strauss (1865) discovered _Metacopaivic
Acid_ which is probably identical with gurjunic; the former, however,
fuses at 206° C.

The amorphous resin forming the chief bulk of the residue of the
distillation of the balsam, has not yet been submitted to exact
analysis. We find that after complete desiccation it is not soluble
in absolute alcohol. A crystallized constituent of Gurjun, which
we obtained from a balsam of unknown origin, has been shown[371]
to answer to the formula C₂₈H₄₆O₂. Its crystals, belonging to the
asymmetric system, melt at 126°-130°C.; they are entirely devoid of
acid character. A comparative examination of the product of each of the
above named species of Dipterocarpus would be highly desirable.

=Commerce=—Gurjun balsam is exported from Singapore, Moulmein, Akyab
and the Malayan Peninsula, and is a common article of trade in Siam. It
is likewise produced in Canara in Southern India. It is occasionally
shipped to Europe. More than 2000 lb. were offered for sale in London
under the name of _East India Balsam Capivi_, 4th October 1855; and
in October 1858, a no less quantity than 45 casks appeared in the
catalogue of a London drug-broker. It is now not unfrequent in the
London drug sales.

=Uses=—In medicine it has hitherto been employed only as a substitute
for copaiba, and chiefly in the hospitals of India.

In the East its great use is as a natural varnish, either alone
or combined with pigments; and also as a substitute for tar as an
application to the seams of boats, and for preserving timber from the
attacks of the white ant. To the first application it is often made
better appropriated[372] by boiling it, so that the essential oil is
evaporated.

_Wood Oil of China_—The oleo-resin of Dipterocarpus must not be
confounded with the so-called _Wood Oil_ of China, which is of a
totally different nature. The latter is a fatty oil expressed from
the seeds of _Aleurites cordata_ Müll. Arg. (_Dryandra cordata_
Thunb. _Elaeococca Vernicia_ Sprgl. Prodromus xv. part 2, p. 724),
the well-known _Tung_ tree of the Chinese. It is a large tree of the
order _Euphorbiaceæ_, found in China and Japan. The oil is an article
of enormous consumption among the Chinese, who use it in the caulking
and painting of junks and boats, for preserving woodwork, varnishing
furniture, and also in medicine. In the commercial reports of H.M.
Consuls in China (No. 5, 1875, p. 3, 26) we find that this oil is
largely exported from Hankow: 199·654 peculs in 1874, and forms an
article of import at Ningpo: 15·123 peculs in 1874 (pecul = 133·33 lb.
avoirdupois). It is, however, not shipped to foreign countries. The
oil of the Tung tree is also extremely remarkable on account of its
chemical properties as shown by Cloëz (1875-1877).

[371] Flückiger, _Pharm. Journ._ (1878) 725, with fig.

[372] _Catalogue of the French Colonies_, _Paris Exhibition_, 1878,
101, quoted above.




MALVACEÆ.


RADIX ALTHÆÆ

_Marshmallow Root_; F. _Racine de Guimauve_; G. _Eibischwurzel_.

=Botanical Origin=—_Althæa officinalis_ L., the marshmallow, grows in
moist places throughout Europe, Asia Minor, and the temperate parts of
Western and Northern Asia, but is by no means universally distributed.
It prefers saline localities such as in Spain the salt marshes of
Saragossa, the low-lying southern coasts of France near Montpellier,
Southern Russia, and the neighbourhood of salt-springs in Central
Europe. In southern Siberia Althæa has been met with by Semenoff (1857)
ascending as high as 3,000 feet in the Alatau mountains, south of the
Balkash Lake.

In Britain it occurs in the low grounds bordering the Thames below
London, and here and there in many other spots in the south of England
and of Ireland.

The cultivated marshmallow thrives as far north as Throndhjem in
Norway, and has been naturalized in North America (salt marshes of
New England and New York) and Australia. It is largely cultivated in
Bavaria and Württemberg.

=History=—Marshmallow had many uses in ancient medicine, and is
described by Dioscorides as Άλθαία, a name derived from the Greek verb
ἀλθειν, _to heal_.

The diffusion of the plant in Europe during the middle ages was
promoted by Charlemagne who enjoined[373] its culture (A.D. 812) under
the name of “_Mismalvas_, id est alteas quod dicitur ibischa.”

=Description=—The plant has a perennial root attaining about a foot in
length and an inch in diameter. For medicinal use the biennial roots
of the cultivated plant are chiefly employed. When fresh they are
externally yellowish and wrinkled, white within and of tender fleshy
texture. Previous to drying, the thin outer and a portion of the middle
bark are scraped off, and the small root filaments are removed. The
drug thus prepared and dried consists of simple whitish sticks 6 to 8
inches long, of the thickness of the little finger to that of a quill,
deeply furrowed longitudinally and marked with brownish scars. Its
central portion, which is pure white, breaks with a short fracture, but
the bark is tough and fibrous. The dried root is rather flexible and
easily cut. Its transverse section shows the central woody column of
undulating outline separated from the thick bark by a fine dark outline
shaded off outwards.

The root has a peculiar though very faint odour, and is of rather
mawkish and insipid taste, and very slimy when chewed.

[373] Pertz, _Monumenta Germaniæ historica_, Legum tom. i. (1835)
181.—_Ibischa_ from the Greek ὶβίσκος.

=Microscopic Structure=—The greater part of the bark consists of liber,
abounding in long soft fibres, to which the toughness of the cortical
tissue is due. They are branched and form bundles, each containing from
3 to 30 fibres separated by parenchymatous tissue. Of the cortical
parenchyme many cells are loaded with starch granules, others contain
stellate groups of oxalate of calcium, and a considerable number of
somewhat larger cells are filled with mucilage. The last named on
addition of alcohol is seen to consist of different layers.

The woody part is made up of pitted or scalariform vessels, accompanied
by a few ligneous cells and separated by a parenchymatous tissue,
agreeing with that of the bark. On addition of an alkali, sections of
the root assume a bright yellow hue.

=Chemical Composition=—The mucilage in the dry root amounts to about
25 per cent. and the starch to as much more. The former appears from
the not very accordant analysis of Schmidt and of Mulder to agree
with the formula C₁₂H₂₀O₁₀, thus differing from the mucilage of gum
arabic by one molecule less of water. It likewise differs in being
precipitable by neutral acetate of lead. At the same time it does not
show the behaviour of cellulose, as it does not turn blue by iodine
when moistened with sulphuric acid, and it is not soluble in ammoniacal
solution of oxide of copper.

The root also contains pectin and sugar (cane-sugar according to
Wittstock), and a trace of fatty oil. Tannin is found in very small
quantity in the outer bark alone.

In 1826 Bacon, a pharmacien of Caen, obtained from althæa root crystals
of a substance at first regarded as peculiar, but subsequently
identified with _Asparagin_, C₄H₈N₂O₃, H₂O. It had been previously
prepared (1805) by Vauquelin and Robiquet from Asparagus, and is now
known to be a widely diffused constituent of plants.[374] Marshmallow
root does not yield more than 0·8 to 2·0 per cent. Asparagin
crystallizes in large prisms or octohedra of the rhombic system; it is
nearly tasteless, and appears destitute of physiological action. Its
relation to succinic acid may be thus represented:—

    Succinic acid: C₂H₄ {COOH; Asparagin: C₂H₃(NH₂) {CONH₂
                        {COOH                       {COOH.

Asparagin is quite permanent whether in the solid state or dissolved,
but it is easily decomposed if the solution contains the albuminoid
constituents of the root, which act as a ferment. Leguminous seeds,
yeast or decayed cheese induce the same change, the final product of
which is succinate of ammonium, the asparagin taking the elements of
water and hydrogen set free by the fermentation, thus—

    C₄H₈N₂O₃ + H₂O + 2H = 2NH₄, C₄H₄O₄
    Asparagin.       Succinate of Ammonium.

Under the influence of acids or bases, or even by the prolonged boiling
of its aqueous solution, asparagin is converted into _Aspartate of
Ammonium_, C₄H₆(NH₄)NO₄, of which the hydrated asparagin contains the
elements.

[374] It plays an interesting part in the germination of the seeds of
papilionaceous and other plants. It is abundant in the young plants,
but in most it speedily disappears. Its presence can be proved in the
juice by means of the microscope and absolute alcohol, in which latter
asparagin is insoluble. See Pfeffer in Pringsheim’s _Jahrb. f. wiss.
Bot._ 1872. 533-564.—Borodin in _Bot. Zeitung_, 1878. 801 and seq.

These transformations, especially the former, are undergone by the
asparagin in the root, if the latter has been imperfectly dried, or has
been kept long, or not very dry. Under such conditions, the asparagin
gradually disappears, and the root then yields a brownish decoction,
sometimes having a disagreeable odour of butyric acid. There is no
doubt that a protein-substance here acts as a ferment. The sections
of the root when touched with ammonia or caustic lye should display a
bright yellow, not a dingy brown, colour.

The peeled root dried at 100° C. and incinerated afforded us 4·88 of
ash, rich in phosphates.

=Uses=—Althæa is taken as a demulcent; it is sometimes also applied as
an emollient poultice. It is far more largely used on the continent
than in England.


FRUCTUS HIBISCI ESCULENTI.

_Capsulæ Hibisci esculenti_; _Uëhka_, _Okro_, _Okra_, _Bendi-kai_[375];
F. _Gombo_ (in the French Colonies).

=Botanical Origin=—_Hibiscus esculentus_ L. (_Abelmoschus esculentus
Guill. et Perr._) an herbaceous annual plant 2 to 3 or even 10 feet
high, indigenous to the Old World.[376] It has been found growing
abundantly wild on the White Nile by Schweinfurth, and also in 1861 by
Col. Grant in Unyoro, 2° N. lat., near the lake Victoria Nyanza, where
it is known to the natives as Bameea.

The plant is now largely cultivated in several varieties in all
tropical countries.

=History=—The Spanish Moors appear to have been well acquainted with
_Hibiscus esculentus_, which was known to them by the same name that
it has in Persian at the present day—_Bámiyah_. Abul Abbas el-Nebáti,
a native of Seville learned in plants, who visited Egypt in A.D. 1216,
describes[377] in unmistakeable terms the form of the plant, its seeds
and fruit, which last he remarks is eaten when young and tender with
meat by the Egyptians. The plant was figured among Egyptian plants in
1592 by Prosper Alpinus,[378] who mentions its uses as an external
emollient.

The powdered fruits as imported from Arabia Felix were known for some
time (about the year 1848) in Europe as _Nafé of the Arabs_. They are
noticed in the present work from the circumstance that they have a
place in the _Pharmacopœia of India_.

=Description=—The fruit is a thin capsule, 4 to 6 or more inches long
and about an inch in diameter, oblong, pointed, with 5 to 7 ridges
corresponding to the valves and cells, each of which latter contains a
single row of round seeds. It is covered with rough hairs and is green
or purplish when fresh; it has a slightly sweet mucilaginous taste and
a weak herbaceous odour. Like many other plants of the order, _Hibiscus
esculentus_ abounds in all its parts with insipid mucilage.

[375] Uëhka in Arabic, according to Schweinfurth. _Okro_ or _Okra_ are
common names for the plant in the East and West Indies. _Bendi-kai_, a
Canarese and Tamil word, is used by Europeans in the South of India.
_Gigambo_ in Curaçao.

[376] Fig. Bentley and Trimen, _Med. Plants_, part 35 (1878).

[377] Ibn Baytar, Sontheimer’s translation, i. 118; Wüstenfeld,
_Geschichte der Arab. Aerzte_ etc. 1840. 118.

[378] _De plant. Ægypt._, Venet. 1592. cap. 27.

=Microscopic Structure=—A characteristic part for microscopic
examination are the hairs of the fruit. They exhibit at the base one
large cell, but their elongated and often slightly curved end is built
up at a considerable number of small cells, without any solid contents.
The middle and outer zone of the pericarp shows enormous holes filled
up with colourless mucilage. In polarized light it is easily seen to be
composed of successive layers.

=Chemical Composition=—It is probable that the fruits contain the same
mucilage as _Althæa_, but we have had no opportunity of investigating
the fact. Landrin[379] says it turns violet with iodine and yields no
mucic acid when treated with nitric acid. Popp, who examined the green
fruits in Egypt, states[380] that they abound in pectin, starch and
mucilage. He found that when dried they afforded 2 to 2·4 per cent. of
nitrogen, and an ash rich in salts of lime, potash and magnesia. The
ripe seeds gave 2·4-2·5 per cent. of nitrogen; their ash 24 per cent.
of phosphoric acid.

=Uses=—The fresh or dried, unripe fruits are used in tropical countries
as a demulcent like marshmallow, or as an emollient poultice, for which
latter purpose the leaves may also be employed. They are more important
from an economic point of view, being much employed for thickening
soups or eaten boiled as a vegetable. The root has been recommended as
a substitute for that of _Althæa_.[381] The stems of the plant yield a
good fibre.




STERCULIACEÆ.


=OLEUM CACAO.=

_Butyrum Cacao_, _Oleum Theobromatis_; _Cacao Butter_, _Oil of
Theobroma_; F. _Beurre de Cacao_; G. _Cacaobutter_, _Cacaotalg_.

=Botanical Origin=—Cacao seeds (from which Cacao Butter is extracted)
are furnished by _Theobroma Cacao_ L., and apparently also by _Th.
leiocarpum_ Bernoulli, _Th. pentagonum_ Bern., and _Th. Salzmannianum_
Bern.[382] These trees are found in the northern parts of South America
and in Central America as far as Mexico, both in a wild state and in
cultivation.

=History=—Cacao seeds were first noticed by Capitan Gonzalo Fernandez
de Oviedo y Valdés (1514-1523), who stated[383] that they had been
met with by Columbus, being used among the inhabitants of Yucatan
instead of money. They were likewise pointed out to Charles V., by
Cortes in one of his letters to the Emperor, dated Temixtitan, Sept.
3rd 1526.[384] The tree as well as the seeds and their uses, were at
length described by Benzoni,[385] who lived in the new world from 1541
to 1555. Clusius figured the seeds in his “Notæ in Garciæ Aromatum
historiam,” Antwerpiæ, 1582.

[379] _Journ. de Pharm._ 22 (1875) 278.

[380] _Archiv der Pharmacie_, cxcv. (1871) 142.

[381] Della Sudda, _Rép. de Pharm._, Janvier, 1860. 229.

[382] Bernoulli, _Uebersicht der bis jetzt bekannten Arten von
Theobroma_.—Reprinted from _Denkschriften der Schweizerischen
Gesellschaft für Naturwissenschaften_, xxiv. (Zürich, 1869) 4°. 376.

[383] _Historia general y naturel de las Indias islas y terra firme del
mar oceano_, iii. (Madrid, 1853) 253.

[384] Vedia, _Cartas de relacion enviadas al emperador Carlos V. desde
Nueva España_. Madrid, 1852. T. 1.

[385] Chavveton (Urbain) _Hist. nouv. du Nouveau Monde ... extraite
del’ italien de M. Hierosme Benzoni Milanais_. 1579. p. 504.

Cacao butter was prepared and described by Homberg[386] as early as
1695, at which time it appears to have had no particular application,
but in 1719 it was recommended by D. de Quelus[387] both for ointments
and as an aliment.

An essay published at Tübingen in 1735[388] called attention to it
as “_novum atque commendatissimum medicamentum_.” A little later it
is mentioned by Geoffroy[389] who says that it is obtained either by
boiling or by expressing the seeds, that it is recommended as the basis
of cosmetic pomades and as an application to chapped lips and nipples,
and to hæmorrhoids.

=Production=—Cacao butter is procured for use in pharmacy from the
manufacturers of chocolate, who obtain it by pressing the warmed seeds.
These in the shelled state yield from 45 to 50 per cent. of oil. The
natural seeds consist of about 12 per cent. of shell (testa) and 88 of
kernels (cotyledons).

=Description=—At ordinary temperatures cacao butter is a light
yellowish, opaque, dry substance, usually supplied in the form of
oblong tablets having somewhat the aspect of white Windsor soap. Though
unctuous to touch, it is brittle enough to break into fragments when
struck, exhibiting a dull waxy fracture. It has a pleasant odour of
chocolate, and melts in the mouth with a bland agreeable taste. Its sp.
gr. is 0·961; its fusing point 20° to 30° C.

Examined under the microscope by polarized light, cacao butter is seen
to consist of minute crystals. It is dissolved by 20 parts of boiling
absolute alcohol, but on cooling separates to such an extent that the
liquid retains not more than 1 per cent. in solution. The fat separated
after refrigeration is found to have lost most of its chocolate
flavour. Litmus is not altered by the hot alcoholic solution.

Cacao butter in small fragments is slowly dissolved by double its
weight of benzol in the cold (10° C.), but by keeping partially
separates in crystalline warts.

=Chemical Composition=—The fat under notice is composed, in common with
others, of several bodies which by saponification furnish glycerin and
fatty acids. Among the latter occurs also oleic acid,[390] contained in
that part of the cacao butter which remains dissolved in cold alcohol
as above stated. In fact by evaporating that solution a soft fat is
obtained. But the chief constituents of cacao butter appear to be
stearin, palmitin, and another compound of glycerin containing probably
an acid of the same series richer in carbon,—perhaps arachic acid,
C₂₀H₄₀O₂, or “_theobromic acid_” C₆₄H₁₂₈O₂, as suggested in 1877 by
Kingzett.

[386] _Hist. d. l’Acad. Roy. des Sciences_, tome ii. depuis 1686
jusqu’à 1699, Paris, 1733. p. 248.

[387] _Hist. nat. du Cacao et du Sucre_, Paris, 1719. (According to
Haller, _Bibl. Bot._ ii. 158.)

[388] B. D. Mauchart præside—dissertation _Butyrum Cacao_. Resp.
Theoph. Hoffmann.

[389] _Tract. de Mat. Med._ ii. (1741) 409.

[390] See article _Amygdalæ dulces_.

=Uses=—Cacao butter, which is remarkable for having but little tendency
to rancidity, has long been used in continental pharmacy; it was
introduced into England a few years ago as a convenient basis for
suppositories and pessaries.

=Adulteration=—The description given of the drug sufficiently indicates
the means of ascertaining its purity.




LINEÆ.


SEMEN LINI.

_Linseed_, _Flax Seed_; F. _Semence de Lin_; G. _Leinsamen_,
_Flachssamen_.

=Botanical Origin=—_Linum usitatissimum_ L., Common Flax, is an annual
plant, native of the Old World, where it has been cultivated from the
remotest times. It sows itself as a weed in tilled ground, and is
now found in all temperate and tropical regions of the globe. Heer
regards it as a variety evolved by cultivation from the perennial _L.
angustifolium_ Huds.

=History=—The history of flax, its textile fibre and seed, is
intimately connected with that of human civilisation. The whole process
of converting the plant into a fibre fit for weaving into cloth is
frequently depicted on the wall-paintings of the Egyptian tombs.[391]
The grave-clothes of the old Egyptians were made of flax, and the use
of the fibre in Egypt may be traced back, according to Unger,[392] as
far as the 23rd century B.C. The old literature of the Hebrews[393]
and Greeks contains frequent reference to tissues of flax; and fabrics
woven of flax have actually been discovered together with fruits
and seeds of the plant in the remains of the ancient pile-dwellings
bordering the lakes of Switzerland.[394]

The seed in ancient times played an important part in the alimentation
of man. Among the Greeks, Alcman in the 7th century B.C., and the
historian Thucydides, and among the Romans Pliny, mention linseed
as employed for human food. The roasted seed is still eaten by the
Abyssinians.[395]

Theophrastus expressly alludes to the mucilaginous and oily properties
of the seed. Pliny and Dioscorides were acquainted with its medical
application both external and internal. The latter, as well as
Columella, exhaustively describes flax under its agricultural aspect.
In an edict of the Emperor Diocletian _De pretiis rerum venalium_[396]
dating A.D. 301, linseed is quoted 150 _denarii_, sesamé seed 200, hemp
seed 80, and poppy seed 150, the _modius castrensis_, equal to about
880 cubic inches.[397] The propagation of flax in Northern Europe as of
so many other useful plants was promoted by Charlemagne.[398] It seems
to have reached Sweden and Norway before the 12th century.[399]

[391] Wilkinson, _Ancient Egyptians_, iii. (1837) 138, &c.

[392] _Sitzungsberichte der Wiener Akademie_, Juni 1866.

[393] Exod. ix. 31; Lev. xiii. 47, 48; Isaiah xix. 9.

[394] Heer in Trimen’s _Journ. of Bot._ i. (1872) 87.

[395] A. de Candolle, _Géogr. Botanique_, 835.—A. Braun, _Flora_, 1848.
94.

[396] See p. 65, note 1.

[397] The English _imperial gallon_ = 277·27 cubic inches.

[398] For further historical information on flax in ancient times, we
may refer to Hehn, _Kulturpflanzen und Hausthiere ..._ Berlin, 1870.
97, 430.

[399] Schübeler, _Die Pflanzenwelt Norwegens_, Christiania, 1873-1875.
p. 332.

=Description=—The capsule which is globose splits into 5 carpels,
each containing two seeds separated by a partition. The seeds are of
flattened, elongated ovoid form with an acute edge, and a slightly
oblique point blunt at one end. They have a brown, glossy, polished
surface which under a lens is seen to be marked with extremely fine
pits. The hilum occupies a slight hollow in the edge just below the
apex. The testa which is not very hard encloses a thin layer of
albumen surrounding a pair of large cotyledons having at their pointed
extremity a straight embryo. The seeds of different countries vary
from ¼ to ⅙ of an inch in length, those produced in warm regions being
larger than those grown in cold. We find that 6 seeds of Sicilian
linseed, 13 of Black Sea and 17 of Archangel linseed weigh respectively
_one grain_.

When immersed in water, the seeds become surrounded by a thin,
slippery, colourless, mucous envelope, which quickly dissolves as a
neutral jelly, while the seed slightly swells and loses its polish. The
seed when masticated has a mucilaginous oily taste.

=Microscopic Structure=—On examining the testa under almond oil or oil
of turpentine, the outlines of the epidermal cells are not distinctly
visible. But under dilute glycerin or in water the epidermis quickly
swells up to 3 or 4 times its original thickness; on warming, the
entire epidermis is resolved into mucilage, except a thin skeleton
of cell-walls, which withstands even the action of caustic lye. The
formation of the mucilage may be conveniently studied by the use of a
solution of ferrous sulphate, with which thin sections of the testa
should be moistened. Other structural peculiarities may be seen if they
are imbued with concentrated sulphuric acid, washed and then moistened
with a solution of iodine. The application of polarized light is also
useful. By the latter means crystalloid granules of albuminoid matter
become visible if the sections are examined under oil. The tissue of
the albumen and the cotyledons abounds in drops of fatty oil.

=Chemical Composition=—The constituent of chief importance is the fixed
oil which the seed contains to about ⅓ of its weight. The proportion
obtained by pressure on a large scale is 20 to 30 per cent. varying
with the quality of the seed. The oil when pressed without heat and
when fresh has but little colour, is without unpleasant taste, and does
not solidify till cooled to -20° C. The commercial oil however is dark
yellow, and has a sharp repulsive taste and odour. On exposure to the
air, especially after having been heated with oxide of lead, it quickly
dries up to a transparent varnish consisting chiefly of _Linoxyn_,
C₃₂H₅₄O₁₁. The crude oil increases in weight 11 to 12 per cent.,
although at the same time its glycerin is destroyed by oxidation.

By saponification, linseed oil yields glycerin, and 95 per cent.
of fatty acids, consisting chiefly of _Linoleic Acid_, C₁₆H₂₆O₂,
accompanied by some oleic, palmitic, and myristic acid. The action
of the air transforms linoleic acid into the resinoid _Oxylinoleic
Acid_, C₁₆H₂₆O₅. Linoleic acid appears to be contained in all drying
oils, notably in that of poppy seed. It is not homologous either
with ordinary fatty acids or with the oleic acid of oil of almonds,
C₁₈H₃₄O₂. The chemistry of the drying oils, especially those of linseed
and poppy, has been particularly investigated by Mulder.[400]

The viscid mucilage of linseed cannot be filtered till it has been
boiled. It contains in the dry state more than 10 per cent. of mineral
substances, when freed from which and dried at 110° C. it corresponds,
like althæa-mucilage, to the formula C₁₂H₂₀O₁₀. The seeds by exhaustion
with cold or warm water afford of it about 15 per cent. By boiling
nitric acid it yields crystals of mucic acid; by dilute mineral acids
it is broken up into dextrogyre gum and sugar and cellulose.[401]

Linseed contains about 4 per cent. of nitrogen corresponding to about
25 per cent. of protein-substances. After expression of the oil these
substances remain in the cake so completely that the latter contains
5 per cent. of nitrogen, and constitutes a very important article for
feeding cattle.

In the ripe state linseed is altogether destitute of starch, though
this substance is found in the immature seed in the very cells which
subsequently yield the mucilage. The latter may be regarded as in
analogous cases to be a product of the transformation of starch.

The amount of water retained by the air-dry seed is about 9 per cent.

The mineral constituents of linseed, chiefly phosphates of potassium,
magnesium, and calcium, amount on an average to 3 per cent., and
pass into the mucilage. By treating thin slices of the testa and its
adhering inner membrane with ferrous sulphate, it is seen that this
integument is the seat of a small amount of tannin.

=Production and Commerce=—Flax is cultivated on the largest scale in
Russia, from which country there was imported into the United Kingdom
in 1872 linseed to the value of 3 millions sterling. The shipments were
made in about equal proportion from the northern and the southern ports
of Russia.

The imports from India in the same year amounted in value to
£1,144,942, and from Germany and Holland to £144,108. The total import
in 1872 was 1,514,947 quarters, value £4,513,842.

The cultivation of flax in Great Britain appears to be declining. The
area under this crop in 1870 was 23,957 acres; in 1871, 17,366 acres;
in 1872, 15,357 acres; and in 1873, 14,683 acres. The last named
area reckoning the yield at 2 to 2½ quarters of seed per acre would
represent a production of about 30,000 to 38,000 quarters.

[400] His numerous investigations on this subject have been published
in a separate pamphlet, of which we have before us a German
translation: G. J. Mulder, _Die Chemie der austrocknenden Oele_ ...
Berlin, 1867, pp. 255.

[401] Kirchner and Tollens, _Annalen der Chemie_, 175 (1874) 215.

In English price-currents, eight sorts of linseed are enumerated,
namely, English, Calcutta, Bombay, Egyptian, Black Sea and Azof,
Petersburg, Riga, Archangel. The first three appear to fetch the
highest prices.

=Uses=—In medicine, linseed is chiefly used in the form of poultice
which may be made either of the seed simply ground or of the pulverized
cake. In either case the powder should not be long stored, as the oil
in the comminuted seed is rapidly oxidized and fatty acids produced.
An infusion of the seeds called _Linseed Tea_ is a common popular
demulcent remedy.

=Adulteration=—Linseed is very liable to adulteration with other seeds,
especially when the commodity is scarce. The admixture in question
is due in part to careless harvesting and in part to intentional
additions. In 1864 the impure condition of the linseed shipped to
the English market had become so detrimental to the trade that the
importers and crushers founded an association called _The Linseed
Association of London_, by which they bound themselves to refuse all
linseed containing more than 4 per cent. of foreign seeds, and this
step very rapidly improved the quality of the article.[402]

[402] Greenish in _Yearbook of Pharmacy_, 1871. 590; _Pharm. Journ._
Sept. 9, 1871. 211.

As the druggist has to _purchase_ linseed meal, he must of necessity
rely to some extent on the character of the oil-presser from whom he
derives his supplies. The presence of the seeds of _Cruciferæ_ (as
rape and mustard) which is common, may be recognized by the pungent
odour of the essential oil which they develope in contact with water.
The introduction of cereals would also be easily discovered by iodine,
which strikes no blue colour in a decoction of linseed. The microscope
will also afford important aid in the examination of linseed cake or
meal.




ZYGOPHYLLEÆ.


LIGNUM GUAIACI.

_Lignum sanctum_; _Guaiacum Wood_, _Lignum Vitæ_; F. _Bois de Gaïac_;
G. _Guaiakholz_, _Pockholz_.

=Botanical Origin=—This wood is furnished by two West Indian species of
_Guaiacum_, namely:—

1. _G. officinale_ L., a middle-sized or low evergreen tree, with
light blue flowers, parapinnate leaves having ovate, very obtuse
leaflets in 2, less often in 3 pairs, and 2-celled fruits. It grows in
Cuba, Jamaica (abundantly on the arid plains of the south side of the
island), Les Gonaives in the N.W. of Hayti (plentiful), St. Domingo,
Martinique, St. Lucia, St. Vincent, Trinidad, and the northern coast
of the South American continent. This tree affords the Lignum Vitæ of
Jamaica (of which very little is imported), a portion of that shipped
from the ports of Hayti, and probably the small quantity exported by
the United States of Colombia.

2. _G. sanctum_ L., a tree much resembling the preceding, but
distinguishable by its leaves having 3 to 4 pairs of leaflets which
are very obliquely obovate or oblong, passing into rhomboid-ovate, and
mucronulate; and a 5-celled fruit. It is found in Southern Florida, the
Bahama Islands, Key West, Cuba, St. Domingo (including the part called
Hayti) and Puerto Rico, and is certainly the source of the small but
excellent Lignum Vitæ exported from the Bahamas as well as of some of
that shipped from Hayti.

=History=—There can be no doubt but that the earliest importations
of Lignum Vitæ were obtained from St. Domingo, of which island,
Oviedo[403] who landed in America in 1514 mentions the tree, under the
name of _Guayacan_, as a native. He points out its fruits as yellow and
resembling two joined lupines, which could only be said with reference
to _G. officinale_, and would not apply to the ovoid five-cornered
fruits of _G. sanctum_. Oviedo appears however to have been aware of
two species, one of which he found in Española (St. Domingo) as well as
in Nagrando (Nicaragua) and the other in the island of St. John (Puerto
Rico), whence it was called _Lignum sanctum_.

The first edition of Oviedo was printed in 1526; but some years before
this the wood must have been known in Germany, as is evident by the
treatises written in 1517, 1518, and 1519 by Nicolaus Poll,[404]
Leonard Schmaus[405] and Ulrich von Hutten.[406] The last which gives
a tolerable description of the tree, its wood, bark, and medicinal
properties, was translated into English in 1533 by Thomas Paynel, canon
of Merton Abbey, and published in London in 1536 under the title—“_Of
the wood called Guaiacum that healeth the Frenche Pockes and also
helpeth the gout in the feete, the stoone, the palsey, lepree, dropsy,
fallynge euyll, and other dyseases._” It was several times reprinted.

In the old pharmacy the products of destructive distillation of
guaiacum wood were known as _Oleum ligni sancti_. It must have
consisted of the substances which we mention further on in the
following article.

=Description=—The wood (always known in commerce as _Lignum Vitæ_) as
imported consists of pieces of the stem and thick branches, usually
stripped of bark, and often weighing a hundredweight each. It is
remarkably heavy and compact. Its sp. gr. which exceeds that of most
woods is about 1·3.

Lignum Vitæ is mostly imported for turnery,[407] and the chips,
raspings and shavings are the only form in which it is commonly seen in
pharmacy. A stem 7 to 8 inches in diameter cut transversely exhibits a
light-yellowish zone of sapwood about an inch wide, enclosing a sharply
defined heartwood of a dark greenish brown. Both display alternate
lighter and darker layers, which especially in the sapwood are further
distinguished by groups of vessels. In this manner are formed a large
number of circles resembling annual rings, the general form of which
is evident, though the individual rings are by no means well defined.
More than 20 such rings may be counted in the sapwood of a log such
as we have mentioned, and more than 30 in the heartwood. The pithless
centre is usually out of the axis. The medullary rays are not visible
to the naked eye, but may be seen by a lens to be very numerous and
equidistant. The pores of the heartwood may be distinguished as
containing a brownish resin, while those of the outermost layer of
sapwood are empty.

[403] _Natural Hystoria de las Indias_, Toledo, 1526. fol. xxxvii.

[404] _Decura Morbi Gallici per Lignum Guayacanum libellus_, printed in
1535 but dated 19 Dec. 1517, 8 pages 8°.

[405] _De Morbo Gallico tractatus_, Salisburgi, November
1518,—reprinted in the _Aphrodisiacus_ of Luisinus, Lugd. Bat. 1728.
383.—We have only seen the latter.

[406] _Ulrichi de Hutten equitis de Guaiaci medicina et morbo gallico
liber unus_, 4°. (26 chapters) Moguntiæ, 1519.

[407] It is much used for the wheels (technically “_sheaves_”) of
ships’ blocks (pulleys), the circumference of which ought to consist of
the white sapwood. It is also required for caulking mallets, skittle
balls and for the large balls used in American bowling alleys, for
which purposes it should be as sound and homogeneous as possible.

In the thickest pieces sapwood is wanting, and even in stems of about a
foot in diameter it is reduced to ⅕ of an inch. It is of looser texture
than the heartwood and floats on water, whereas the latter sinks. Both
sapwood and heartwood owe their tenacity to an extremely peculiar
zigzag arrangement[408] of the woody bundles. The sapwood is tasteless.
The heartwood has a faintly aromatic and slightly irritating taste, and
when heated or rubbed emits a weak agreeable odour.

The bark which was formerly officinal but is now almost obsolete, is
very rich in oxalate of calcium and affords upon incineration not less
than 23 per cent. of ash. It contains a resin distinct from that of the
wood, and also a bitter acrid principle.[409]

The Lignum Vitæ of Jamaica (_G. officinale_) and that of the Bahamas
(_G. sanctum_), of which authentic specimens have been kindly placed at
our disposal by Mr. G. Shadbolt, display the same appearance as well as
microscopic structure.[410]

=Microscopic Structure=—The wood consists for the most part of pointed,
not very long, ligneous cells (libriform), traversed by one-celled
rows of medullary rays. There are also thin layers of parenchymatous
tissue, to which the zones apparent in a transverse section of the
drug are due. The pitted vessels are comparatively large but not very
numerous. The structure of the sapwood is the same as that of the
heartwood, but in the latter the ligneous cells are filled with resin.
The parenchymatous cells contain crystals of oxalate of calcium.

=Chemical Composition=—The only constituent of any interest is the
resin which the heartwood contains to the extent of about a fourth of
its weight. The sapwood afforded us 0·91 and the heartwood 0·60 per
cent. of ash.

=Commerce=—Lignum Vitæ varies much in estimation, according to size,
soundness, and the cylindrical form of the logs. The best is exported
from the city of Santo Domingo, whither it is brought from the interior
of the island. The quantity shipped from this port during 1871 was 1494
tons;[411] 220 tons were exported in 1877 from Puerto Plata on the
northern coast of the island. The wood obtained from the Haytian ports
(of the western part of the same island) is much less esteemed in the
London market.

[408] It has been remarkably well pointed out already by Valerius
Cordus (_obiit_ 1544). See Gesner’s edition of his _Hist. Stirpium
Argentorat_., 1561. 191.

[409] See also Oberlin et Schlagdenhauffen, _Journ. de Pharm._ 28
(1878) 246 and plate vi.

[410] That of _Guaiacum arboreum_ DC. is apparently very different.
This tree, occurring in New Granada, has already been noticed
(1571-1577) by Francisco Hernandez (_Nova plantarum, animal, et
mineral. mexicanor. hist._, Romæ 1651, fol. 63) under the name of
_Guayacan_. He mentions its large umbels with yellow flowers, those of
Guaiacum officinale, the “_Hoaxacan_” or Lignum sanctum, being blue. In
the _Prodromus Floræ Neo-Granatentis_ (_Ann. Scienc. nat._ xv., 1872.
p. 361) J. E. Planchon also describes Guaiacum arboreum, known there as
_Guayacan polvillo_; its wood is of an almost pulverulent fracture.

[411] _Consular Reports_ presented to Parliament, Aug. 1872.

Some small wood of good quality comes from the Bahamas, and an ordinary
quality, also small, from Jamaica. From the latter island, the quantity
exported in 1871 was only 14 tons;[412] from the Bahamas in the same
year 199 tons.[413] Lignum Vitæ was shipped from Santa Marta in 1872 to
the extent of 115 tons.[414]

Hamburg is also an important place for the wood under notice; in 1877
there were imported 22,404 centners from S. Domingo and 3551 centners
from Venezuela.

=Uses=—Guaiacum wood is only retained in the pharmacopœia as an
ingredient of the Compound Decoction of Sarsaparilla. It is probably
inert, at least in the manner in which it is now administered.[415]

=Adulteration=—In purchasing guaiacum chips it is necessary to observe
that the non-resinous sapwood is absent, and still more that there is
no admixture of any other wood. A spurious form of the drug seems to be
by no means rare in the United States.[416]


RESINA GUAIACI.

_Guaiacum Resin_; F. _Résine de Gaïac_; G. _Guaiakharz_.

=Botanical Origin=—_Guaiacum officinale_ L., see preceding article.

=History=—Hutten[417] in 1510 stated that guaiacum wood when set on
fire exudes a blackish resin which quickly hardens, but of which he
knew no use. The resin was in fact introduced into medicine much later
than the wood. The first edition of the _London Pharmacopœia_ in which
we find the former named is that of 1677.

=Production=[418]—In the island of St. Domingo, whence the supplies
of guaiacum resin are chiefly derived, the latter is collected from
the stems of the trees, in part as a natural exudation, and in part as
the result of incisions made in the bark. In some districts as in the
island of Gonave near Port-au-Prince, another method of obtaining it is
adopted. A log of the wood is supported in a horizontal position above
the ground by two upright bars. Each end of the log is then set on
fire, and a large incision having been previously made in the middle,
the melted resin runs out therefrom in considerable abundance. 36,350
lbs. of it have been exported in 1875 from Port-au-Prince.

The resin is collected chiefly from _G. officinale_, which affords it
in greater plenty than _G. sanctum_.

[412] Blue Book—Island of Jamaica for 1871.

[413] Blue Book for Colony of Bahamas for 1871.

[414] _Consular Reports_, Aug. 1873. 746.

[415] The ancient treatment of syphilis by guaiacum which gained for
the drug such immense reputation, consisted in the administration of
vast quantities of the decoction, the patient being shut up in a warm
room and kept in bed.—See Hutten’s pamphlet quoted before, and its
numerous reprints and translations.

[416] Schulz, in the (Chicago) _Pharmacist_, Sept. 1873.

[417] _Op. cit._ at p. 101.

[418] We have to thank Mr. Eugène Nau of Port-au-Prince for the
information given under this head, as well as for some interesting
specimens.

=Description=—The resin occurs in globular tears ½ an inch to 1 inch in
diameter, but much more commonly in the form of large compact masses,
containing fragments of wood and bark. The resin is brittle, breaking
with a clean, glassy fracture; in thin pieces it is transparent and
appears of a greenish brown hue. The powder when fresh is grey, but
becomes green by exposure to light and air. It has a slight balsamic
odour and but little taste, yet leaves an irritating sensation in the
throat.

The resin has a sp. gr. of about 1·2. It fuses at 85° C., emitting a
peculiar odour somewhat like that of benzoin. It is easily soluble
in acetone, ether, alcohol, amylic alcohol, chloroform, creosote,
caustic alkaline solutions, and oil of cloves; but is not dissolved
or only partially by other volatile oils, benzol or bisulphide of
carbon. By oxidizing agents it acquires a fine blue colour, well shown
when a fresh alcoholic solution is allowed to dry up in a very thin
layer and this is then sprinkled with a dilute alcoholic solution
of ferric chloride. Reducing agents of all kinds, and heat produce
decoloration. An alcoholic solution may be thus blued and decolorized
several times in succession, but it loses at length its susceptibility.
This remarkable property of guaiacum was utilized by Schönbein in his
well-known researches on ozone.

=Chemical Composition=—The composition of guaiacum resin was
ascertained by Hadelich (1862) to be as follows:—

    Guaiaconic Acid,                                70·3 per cent.
    Guaiaretic Acid,                                10·5   ”
    Guaiac Beta-resin,                               9·8   ”
    Gum,                                             3·7   ”
    Ash constituents,                                0·8   ”
    Guaiacic Acid, colouring matter (Guaiac-yellow),
            and impurities,                          4·9   ”

If the mother-liquor obtained in the preparation of the potassium salt
of guaiaretic acid (_vide infra_) is decomposed by hydrochloric acid,
and the precipitate washed with water, ether will extract from the
mass _Guaiaconic Acid_, a compound discovered by Hadelich, having the
formula C₃₈H₄₀O₁₀. It is a light brown, amorphous substance, fusing at
100° C. It is without acid reaction but decomposes alkaline carbonates,
forming uncrystallizable salts easily soluble in water or alcohol. It
is insoluble in water, benzol, or bisulphide of carbon, but dissolves
in ether, chloroform, acetic acid or alcohol. With oxidizing agents it
acquires a transient blue tint.

_Guaiaretic Acid_, C₂₀H₂₆O₄, discovered by Hlasiwetz in 1859, may be
extracted from the crude resin by alcoholic potash or by quicklime.
With the former it produces a crystalline salt; with the latter an
amorphous compound: from either the liquid, which contains chiefly a
salt of guaiaconic acid, may be easily decanted. Guaiaretic acid is
obtained by decomposing one of the salts referred to with hydrochloric
acid, and crystallizing from alcohol. The crystals, which are soluble
also in ether, benzol, chloroform, carbon bisulphide or acetic acid,
but neither in ammonia nor in water, melt below 80° C., and may be
volatilized without decomposition. The acid is not coloured blue by
oxidizing agents.

By exhausting guaiacum resin with boiling bisulphide of carbon a
slightly yellowish solution is obtained (containing chiefly guaiaretic
acid?), which, on addition of concentrated sulphuric acid, turns
beautifully red.

After the extraction of the guaiaconic acid there remains a substance
insoluble in ether to which the name _Guaiac Beta-resin_ has been
applied. It dissolves in alcohol, acetic acid or alkalis, and is
precipitated by ether, benzol, chloroform or carbon bisulphide in brown
flocks, the composition of which appears not greatly to differ from
that of guaiaconic acid.

_Guaiacic Acid_, C₁₂H₁₆O₆, obtained in 1841 by Thierry from guaiacum
wood or from the resin, crystallizes in colourless needles. Hadelich
was not able to obtain more than one part from 20,000 of guaiacum resin.

Hadelich’s _Guaiac-yellow_, the colouring matter of guaiacum resin,
first observed by Pelletier, crystallizes in pale yellow quadratic
octohedra, having a bitter taste. Like the other constituents of the
resin, it is not a glucoside.

The decomposition-products of guaiacum are of peculiar interest.
On subjecting the resin to dry distillation in an iron retort and
rectifying the distillate, _Guaiacene_ (_Guajol_ of Völckel), C₅H₈O,
passes over at 118° C. as a colourless neutral liquid having a burning
aromatic taste.

At 205°-210° C., there pass over other products, _Guaiacol_,
C₆H₄·OCH₃·OH, (methylic ether of pyrocatechin), and _Kreosol_
C₆H₃·OH(CH₃)₂. Both are thickish, aromatic, colourless liquids, which
become green by caustic alkalis, blue by alkaline earths, and are
similar in their chemical relations to eugenic acid. Guaiacol has been
prepared synthetically by Gorup-Besanez (1868) by combining iodide of
methyl, CH₃I, with pyrocatechin, C₆H₄(OH)₂.

After the removal by distillation of the liquids just described,
there sublime upon the further application of heat pearly crystals
of _Pyroguaiacin_, C₃₈H₄₄O₆, an inodorous substance melting at 180°
C. The same compound is obtained together with guaiacol by the dry
distillation of guaiaretic acid. Pyroguaiacin is coloured green by
ferric chloride, and blue by warm sulphuric acid. The similar reactions
of the crude resin are probably due to this substance (Hlasiwetz).

Beautiful coloured reactions are likewise exhibited by two new acids
which Hlasiwetz and Barth obtained (1864) in small quantity together
with traces of fatty volatile acids, by melting purified resin
of guaiacum with potassium hydrate. One of them is isomeric with
pyrocatechuic acid.

=Uses=—Guaiacum resin is reputed diaphoretic and alterative. It is
frequently prescribed in cases of gout and rheumatism.

=Adulteration=—The drug is sometimes imported in a very foul condition
and largely contaminated with impurities arising from a careless method
of collection.




RUTACEÆ.


CORTEX ANGOSTURÆ.

_Cortex Cuspariæ_; _Angostura Bark_, _Cusparia Bark_, _Carony Bark_; F.
_Ecorce d’Angusture de Colombie_; G. _Angostura-Rinde_.

=Botanical Origin=—_Galipea Cusparia_ St. Hilaire (_G. officinalis_
Hancock, _Bonplandia trifoliata_ Willd., _Cusparia trifoliata_ Engler
1874, _Flora Brasil_. 113), a small tree, 12 to 15 feet high, with a
trunk 3 to 5 inches in diameter, growing in abundance on the mountains
of San Joaquin de Caroni in Venezuela, between 7° and 8° N. lat., also
according to Bonpland[419] near Cumana. According to Hancock,[420] who
was well acquainted with the tree, it is also found in the Missions of
Tumeremo, Uri, Alta Gracia, and Cupapui, districts lying eastward of
the Caroni and near its junction with the Orinoko. The bark is brought
into commerce by way of Trinidad.

=History=—Angostura Bark is said to have been used in Madrid by
Mutis as early as 1759[421] (the year before he left Spain for South
America,) but it was certainly unknown to the rest of Europe until
much later. Its real introducer was Brande, apothecary to Queen
Charlotte, and father of the distinguished chemist of the same name,
who drew attention to some parcels of the bark imported into England
in 1788.[422] In the same year a quantity was sent to a London drug
firm by Dr. Ewer of Trinidad, who describes it[423] as brought to that
island from Angostura by the Spaniards. The drug continued to arrive
in Europe either by way of Spain or England, and its use was gradually
diffused. In South America it is known as _Quina de Caroni_ and
_Cascarilla del Angostura_.

=Description=—The bark occurs in flattish or channelled pieces, or
in quills rarely as much as 6 inches in length and mostly shorter.
The flatter pieces are an inch or more in width and ⅛ of an inch in
thickness. The outer side of the bark is coated with a yellowish-grey
corky layer, often soft enough to be removeable with the nail, and
then displaying a dark brown, resinous under surface. The inner side
is light brown with a rough, slightly exfoliating surface indicating
close adhesion to the wood, strips of which are occasionally found
attached to it; the obliquely cut edge also shows that it is not very
easily detached. The bark has a short, resinous fracture, and displays
on its transverse edge sharply defined white points, due to deposite of
oxalate of calcium. It has a bitter taste and a nauseous musty odour.

[419] Humboldt, _Reise in die Aequinoctialgegenden des neuen
Continents_, iv. (Stuttgart, 1860), 252.—Humboldt and Bonpland in 1804
obtaining, from the Caroni river, flowering branches of the “_Cuspa_”
(_l. c._ 1. 300) or “_Cuspare_,” as it is called by the Indians,
believed it to constitute a new genus. In 1824 St. Hilaire ascertained
it to belong to the genus Galipea.

The tree is figured in Bentley and Trimen, _Med. Plants_, part 26
(1877).

[420] _Observations on the Orayuri or Angustura Bark Tree_,—_Trans.
of Medico-Botanical Society_, 1827-29.—Hancock endeavoured to prove
his tree distinct from _G. Cusparia_ St. Hil., but Farre and Don who
subsequently examined his specimens decided that the two were the
same. With the assistance of Prof. Oliver, I also have examined (1871)
Hancock’s plant, comparing it with his figure and other specimens,
and have arrived at the conclusion that it is untenable as a distinct
species.—D. H.

[421] Martiny, _Encyklopädie_, i. (1843) 242.

[422] Brande, _Experiments and Observations on the Angustura Bark_.
1791. 2nd ed. 1793.

[423] _London Med. Journ._ x. (1789) 154.

=Microscopic Structure=—The most striking peculiarity is the great
number of oil-cells scattered through the tissue of the bark. They
are not much larger than the neighbouring parenchymatous cells, and
are loaded with yellowish essential oil or small granules of resin.
Numerous other cells contain bundles of needle-shaped crystals of
oxalate of calcium or small starch granules. The liber exhibits bundles
of yellow fibres, to which the foliaceous fracture of the inner bark
is due. The structure of the bark under notice has been very minutely
described and figured by Oberlin and Schlagdenhauffen.[424]

=Chemical Composition=—Angostura bark owes its peculiar odour to an
essential oil which it was found by Herzog[425] to yield to the extent
of ¾ per cent. It is probably a mixture of a hydrocarbon (C₁₀H₁₆)
with an oxygenated oil. Its boiling point is 266° C. Oberlin and
Schlagdenhauffen obtained 0·19 per cent. of the oil, and found it to
be slightly dextrogyre; it assumes a fine red colour when shaken with
aqueous ferric chloride, and turns yellow with concentrated sulphuric
acid.

[424] _Journ. de Pharm. et de Chimie_, 28 (1877), 226; plates I, II,
III. The bark is also figured by Berg, _Anatomischer Atlas_, Tab. 37.

[425] _Archiv d. Pharm._ xcii. (1858) 146.

The bitter taste of the bark is attributed to a substance pointed out
in 1833 by Saladin and named _Cusparin_. It is said to be crystalline,
neutral, melting at 45° C., soluble in alcohol, sparingly in water,
precipitable by tannic acid. The bark is stated to yield it to the
extent of 1·3 per cent. Herzog endeavoured to prepare it but without
success, nor have Oberlin and Schlagdenhauffen met with it. The latter
chemists, on the other hand, isolated an alkaloid _Angosturine_
C₁₀H₄₀NO₁₄. It is in thin prisms, melting at 85° and yielding a
crystallized chlorhydrate or sulphate. Angosturine turns red when
touched with concentrated sulphuric acid, or green if nitric acid or
iodic acid, or other oxydizing substances, have been previously mixed
with the sulphuric acid. The alcoholic solution of the alkaloid is of
decidedly alkaline reaction. A cold aqueous infusion of angostura bark
yields an abundant red-brown precipitate with ferric chloride. Thin
slices of the bark are not coloured by solution of ferrous sulphate, so
that tannin appears to be absent.

=Uses=—Angostura bark is a valuable tonic in dyspepsia, dysentery and
chronic diarrhœa, but is falling into disuse.

=Adulteration=—About the year 1804, a quantity of a bark which proved
to be that of _Strychnos Nux Vomica_ reached Europe from India, and
was mistaken for Cusparia. The error occasioned great alarm and
some accidents, and the use of angostura was in some countries even
prohibited. The means of distinguishing the two barks (which are not
likely to be again confounded) are amply contained in the above-given
descriptions and tests, and at length pointed out by Oberlin and
Schlagdenhauffen. They also described the bark of _Esenbeckia
febrifuga_ Martius (_Evodia febrifuga_ Saint Hilaire), a Brazilian
tree belonging to the same natural order. Maisch[426] was the first
to draw attention to this “_new false Angostura bark_.” It is at once
distinguished by being devoid of aromatic properties; its taste is
purely bitter.


FOLIA BUCHU.

_Folia Buceo_; _Buchu_, _Bucchu_, _Bucha or Buka Leaves_; F. _Feuilles
de Bucco_; G. _Bukublätter_.

=Botanical Origin=—The Buchu leaves are afforded by three species of
_Barosma_.[427] The latter are erect shrubs some feet in height, with
glabrous rod-like branches, opposite leaves furnished with conspicuous
oil-cells on the toothed margin as well as generally on the under
surface. The younger twigs and several parts of the flower are also
provided with oil-cells. The white flowers with 5-partite calyx, and
the fruit formed of five erect carpels, are often found, together with
small leafy twigs, in the drug of commerce.

The leaves of the three species referred to may be thus distinguished:—

1. _Barosma crenulata_ Hook. (_B. crenata_ Kunze).—Oblong, oval, or
obovate, obtuse, narrowed towards the base into a distinct petiole;
margin serrulate or crenulate; dimensions, ¾ to 1½ inches long, ³/₁₀ to
⁴/₁₀ of an inch wide.

2. _B. serratifolia_ Willd.—Linear-lanceolate, equally narrowed towards
either end, three-nerved, apex truncate always furnished with an
oil-cell; margin sharply serrulate; 1-1½ inches long by about ²/₁₀ of
an inch wide.

3. _B. betulina_ Bartling.—Cuneate-obovate, apex recurved; margin
sharply denticulate, teeth spreading; ½ to ¾ of an inch long by ³/₁₀
to ⁵/₁₀ wide. Substance of the leaf more harsh and rigid than in the
preceding.

_B. crenulata_ and _B. betulina_ grow in the Divisions of Clanwilliam
and Worcester, north and north-east of Cape Town, and the former even
on Table Mountain close to the capital; _B. serratifolia_ is found in
the Division of Swellendam farther south.

=History=—The use of Buchu leaves was learnt from the Hottentots by the
colonists of the Cape of Good Hope. The first importations of the drug
were consigned to the house of Reece & Co., of London, who introduced
it to the medical profession in 1821.[428] The species appears to have
been _B. crenulata_.

=Description=—In addition to the characters already pointed out, we may
observe that buchu leaves of either of the kinds mentioned are smooth
and glabrous, of a dull yellowish-green hue, somewhat paler on the
under side, on which oil-cells in considerable number are perceptible.

[426] _Am. Journ. of Pharm._ 1874. 50; also _Yearbook of Pharm._ 1874.
91.

[427] From βαρὺς, _heavy_, and ὀσμὴ, _odour_.

[428] R. Reece, _Monthly Gazette of Health_ for Feb. 1821. 799.

The leaves of _B. crenulata_ vary in shape and size in different
parcels, in some the leaves being larger and more elongated than
in others, probably according to the luxuriance of the bushes in
particular localities. Those of _B. serratifolia_ and _B. betulina_
present but little variation. Each kind is always imported by itself.
Those of _B. betulina_ are the least esteemed, and fetch a lower price
than the others, yet appear to be quite as rich in essential oil.

Buchu leaves have a penetrating peculiar odour and a strongly aromatic
taste.

=Microscopic Structure=—The essential oil is contained in large
cells close beneath the epidermis of the under side of the leaf. The
oil-cells are circular and surrounded by a thin layer of smaller cells;
they consequently partake of the character of the oil-ducts in the
aromatic roots of _Umbelliferæ_ and _Compositæ_. The latter, however,
are elongated.

The upper side of the leaf of _Barosma_ exhibits an extremely
interesting peculiarity[429]. There is a colourless layer of cells
separating the epidermis from the green inner tissue (mesophyllum).
If the leaves are examined under alcohol or almond oil the colourless
layer is seen to be very narrow, and the thin walls of its cells
shrunken and not clearly distinguishable. If the transverse sections
are examined under water, these cells immediately swell up, and become
strongly distended, giving off an abundance of mucilage, the latter
being afforded by the solution of the very cell-walls. The mucilage of
buchu leaves thus originates in the same way as in flax seed or quince
seed, but in the former the epidermis is thrown off without alteration.
We are not aware that other mucilaginous leaves possess a similar
structure, at least not those of _Althæa officinalis_ and of _Sesamum_
which we examined[430].

=Chemical Composition=—The leaves of _B. betulina_ afforded us by
distillation 1·56 per cent, of volatile oil[431], which has the odour
rather of peppermint than of buchu, and deviates the ray of polarized
light considerably to the left. On exposure to cold it furnishes a
camphor which, after re-solution in spirit of wine, crystallizes in
needle-shaped forms. After repeated purification in this manner, the
crystals of _Barosma Camphor_ have an almost pure peppermint odour;
they fuse at 85° C., and begin to sublime at 110° C. After fusion
they again solidify only at 50° C. Submitted to elementary analysis,
the crystals yielded us 74·08 per cent. of carbon and from 9 to 10
per cent. of hydrogen[432]. Barosma camphor is abundantly soluble in
bisulphide of carbon.

The crude oil from which the camphor has been separated has a boiling
point of about 200° C., quickly rising to 210° or even higher. That
which distilled between these temperatures was treated with sodium,
rectified in a current of common coal gas and submitted to elementary
analysis, afforded us 77·86 per cent, of carbon and 10·58 of hydrogen.
The formula C₁₀H₁₆O would require 78·94 of carbon and 10·53 of hydrogen.

Wayne’s experiments[433] appear to indicate that the oil also contains
a substance capable of being converted into _salicylic acid_. An
aqueous infusion of buchu leaves turns beautifully yellow if it is
mixed with alkali.

[429] Flückiger in _Schweiz. Wochenschrift für Pharm._ Dec. 1873, with
plate.

[430] See also Radlkofer, _Monographie der Sapindaceen-Gattung
Serjania_, München, 1875, p. 100-105.

[431] Messrs. Allen and Hanburys operating on larger quantities
obtained 1.63 per cent.—_Barosma serratifolia_ appears to be less rich,
according to Bedford (1863).

[432] Our supply of the substance having been exhausted by two analyses
we cannot regard the above figures as sufficient for the calculation of
a formula.

[433] _Am. Journ. of Pharm._ 1876. 19.

On addition of perchloride of iron the infusion assumes a dingy
brownish-green colour changing to red by an alkali. The infusion
added to a concentrated solution of acetate of copper causes a yellow
precipitate[434] which dissolves in caustic potash, affording a green
solution. This may be due to the presence of a substance of the
quercitrin or rutin class.

When the leaves are infused in warm water, the mucilage noticed under
the microscope may easily be pressed out. It requires for precipitation
a large amount of alcohol, being readily miscible with dilute alcohol.
Neutral acetate of lead produces a yellow precipitate in an infusion of
the leaves; the liquid affords a precipitate by a subsequent addition
of _basic_ acetate of lead. The latter precipitate is (probably) due to
the mucilage, that afforded by neutral acetate partly to mucilage and
partly, we suppose, to rutin or an allied substance. Yet the mucilage
of buchu leaves is of the class which is not properly dissolved by
water, but only swells up like tragacanth.

The leaves of _B. crenulata_ afforded us upon incineration 4·7 per
cent. of ash. Jones (1879) obtained on an average 4·54 per cent. from
the same species; 5·27 from _B. serratifolia_; and 4·49 from _B.
betulina_. He pointed out the presence of manganate in this ash.

The _Diosmin_ of Landerer[435] is entirely unknown to us.

=Commerce=—The export of buchu from the Cape Colony in 1872 was 379,125
lb., about one-sixth of which quantity was shipped direct to the United
States.[436]

=Uses=—Buchu is principally administered in disorders of the
urino-genital organs. It is reputed diuretic and diaphoretic. In
the Cape Colony the leaves are much employed as a popular stimulant
and stomachic, infused in water, sherry, or brandy. They are also
extensively used in the United States, both in regular medicine and by
the vendors of secret remedies.

=Substitutes=—The leaves of _Empleurum serrulatum_ Ait., a small shrub
of the same order as _Barosma_ and growing in the same localities,
have been imported rather frequently of late and sold as _Buchu_. They
have the same structure as regards mucilage, and nearly the same form
as those of _B. serratifolia_, but are easily distinguished. They are
still narrower, and often longer than those of _B. serratifolia_,
devoid of lateral veins, and terminate in an _acute_ point _without an
oil-duct_. They have a bitterish taste and a less powerful odour than
those of Barosma, even in fresh leaves as imported in London. The odour
of _Empleurum_ is moreover distinctly different from that of the leaves
of Barosma. The flowers of _Empleurum_ are still more distinct, for
they are apetalous and reddish-brown. The fruit consisting of a single,
compressed, oblong carpel, terminated by a flat-shaped horn, is quite
unlike that of buchu.

The leaves of _Barosma Eckloniana_ Berg (regarded by Sonder[437] as
a form of _B. crenulata_) have to our knowledge been imported on one
occasion (1873). They are nearly an inch long, oval, _rounded at the
base_, strongly crenate, and grow from _pubescent_ shoots.

[434] It seems _green_ as long as it is in the blue cupric liquid.

[435] Gmelin’s _Chemistry_, xviii 194.

[436] _Blue Book_ published at Cape Town, 1873.

[437] Harvey and Sonder, _Flora Capensis_, i. (1859-60) 393.

We have seen other leaves which had been imported from South Africa and
offered as buchu; but though probably derived from allied genera they
were not to be mistaken for the genuine drug.


RADIX TODDALIÆ.

=Botanical Origin=—_Toddalia aculeata_ Pers., a ramous prickly
bush,[438] often climbing over the highest trees, common in the
southern parts of the Indian peninsula as the Coromandel Coast, South
Concans, and Canara, also found in Ceylon, Mauritius, the Indian
Archipelago and Southern China.

=History=—The pungent aromatic properties which pervade the plant,
but especially the fresh root-bark, are well known to the natives of
India and have been utilized in their medical practice. They have also
attracted the attention of Europeans, and the root of the plant is now
recognized in the _Pharmacopœia of India_.

It is from this and other species of _Toddalia_, or from the allied
genus _Zanthoxylum_,[439] that a drug is derived which under the name
of _Lopez Root_ had once some celebrity in Europe. This drug which was
more precisely termed _Radix Indica Lopeziana_ or _Root of Juan Lopez
Pigneiro_, was first made known by the Italian physician Redi,[440]
who described it in 1671 from specimens obtained by Pigneiro at the
mouth of the river Zambesi in Eastern Africa,—the very locality in
which in our times _Toddalia lanceolata_ Lam. has been collected by
Dr. Kirk.[441] It was actually introduced into European medicine by
Gaubius[442] in 1771 as a remedy for diarrhœa, and acquired so much
reputation that it was admitted to the Edinburgh Pharmacopœia of 1792.
The root appears to have been sometimes imported from Goa, but its
place of growth and botanical origin were entirely unknown, and it was
always extremely rare and costly.[443] It has long been obsolete in all
countries except Holland, where until recently it was to be met with in
the shops. The _Pharmacopœia Neerlandica_ of 1851 says of it “_Origo
botanica perquam dubia—Patria Malacca?_”

[438] Fig. in Bentley and Trimen, part 18.

[439] The root of a _Zanthoxylum_ sent to us from Java by Mr. Binnendyk
of the Buitenzorg Botanical Garden has exactly the aspect of that of
_Toddalia_. The root of _Z. Bungei_ which we have examined in the fresh
state is also completely similar. It is covered with a soft, corky,
yellow bark having a very bitter taste with a strong pungency like that
of pellitory.

[440] _Esperienze intorno a diverse cote naturali_, Firenze, 1671. 121.

[441] Oliver, _Flor. of Trop. Africa_, i. (1868) 307.

[442] _Adversaria_, Leidae, p. 78.

[443] Our friend Dr. de Vry informs us that he remembers the price in
Holland in 1828 being equivalent to about 24_s._ the ounce!

=Description=—The specimen of the root of _Toddalia aculeata_ which
we have examined was collected for us by Dr. G. Bidie of Madras whose
statements regarding the stimulant and tonic action of the drug may
be found in the _Pharmacopœia of India_, p. 442. It is a dense woody
root in cylindrical, flexuous pieces, which have evidently been of
considerable length and are from ½ to 1½ inches in diameter, covered
with bark ⅒ to ¹/₁₂ of an inch in thickness. The bark has a soft,
dull yellowish, suberous coat, wrinkled longitudinally, beneath which
is a very thin layer of a bright yellow colour, and still lower and
constituting two-thirds or more of the whole, is the firm, brown middle
cortical layer and liber, which is the part chiefly possessing the
characteristic pungency and bitterness of the drug. The yellow corky
coat is however not devoid of bitterness. The wood is hard, of a pale
yellow, and without taste and smell. The pores of the wood, which
are rather large, are arranged in concentric order and traversed by
numerous narrow medullary rays.

In a letter which Frappier[444] wrote to Guibourt from the island of
Réunion where _Toddalia aculeata_ is very common, he states that the
roots of the plant are of enormous length (_longueur incroyable_) and
rather difficult to get out of the basaltic rock into the fissures of
which they penetrate. Mr. J. Horne of the Botanical Garden, Mauritius,
has sent us a specimen of the root of this plant, the bark of which is
of a dusky brown, with the suberous layer but little developed.

=Microscopic Structure=—We have examined the root for which we are
indebted to Dr. Bidie, and may state that its cortical tissue is
remarkable by the number of large cells filled with resin and essential
oil; they are scattered through the whole tissue, the cork excepted.
The parenchymatous cells are loaded with small starch granules or with
crystals of oxalate of calcium. The vessels of younger roots abound in
yellow resin.

=Chemical Composition=—None of the constituents of the Toddalia root
of India have yet been satisfactorily examined. The bark contains an
essential oil, which would be better extracted from fresh than from
dry material. The tissue of the bark is but little coloured by salts
of iron. In the aqueous infusion, tannic acid produces an abundant
precipitate, probably of an indifferent bitter principle rather than of
an alkaloid. We have been unable to detect the presence in the bark of
berberine.

Lopez root was examined in Wittstein’s laboratory by Schnitzer[445]
who found that the bark contains in addition to the usual substances a
large proportion of resin,—a mixture probably of two or three different
bodies. The essential oil afforded by the bark had an odour resembling
cinnamon and melissa.

=Uses=—The drug has been introduced into the _Pharmacopœia of India_
chiefly upon the recommendation of Dr. Bidie of Madras, who considers
it of great value as a stimulating tonic. The bark rasped or shaved
from the woody root is the only part that should be used.

[444] _Journ. de Phar._ v. (1867) 403.

[445] Wittstein’s _Vierteljahresschrift für prakt. Pharm._ xi. (1862)
i.—The drug examined was the Lopez root sold at that period at
Amsterdam.


FOLIA PILOCARPI.

_Folia Jaborandi_.

=Botanical Origin=—_Pilocarpus pennatifolius_[446] Lemaire, a slightly
branched shrub, attaining about 10 feet in height. It is distributed
through the eastern provinces of Brazil.

_Pilocarpus Selloanus_[447] Engler, occurring in Southern Brazil
and Paraguay, appears to be not considerably different from _P.
pennatifolius_.

=History=—Piso[448] recommended an infusion made with Ipecacuanha and
Jaborandi. Plumier,[449] who also mentioned this, figured under the
name of Jaborandi two plants of the order Piperaceæ. The introduction
of the leaves of _Pilocarpus pennatifolius_ into medical use is due
to Dr. Coutinho of Pernambuco, 1874. The plant has been cultivated in
European greenhouses since about the year 1847; we have repeatedly
seen it flowering at Strassburg. Baillon in 1875 showed the fragments
of Jaborandi as supplied by Coutinho to belong to _P. pennatifolius_,
which had been described in 1852 by Lemaire. Holmes (1875) in examining
the drug as imported from Pernambuco came to the same conclusion.

=Description=—The leaves of the species under examination are
long-stalked, imparipennate, the opposite leaflets in 2 to 5, in
cultivated plants most commonly in 2 pairs, the terminal one longer
stalked, while the others are provided with a petiole attaining 1½
inch in length or remaining much shorter. The whole leaf is frequently
1½ feet long, the leaflets being often as much as 5 inches long by 2
inches wide. The latter are entire oblong, tapering or rounded at the
base, tapering or obtuse or even emarginate at the apex. The leaflets
are coriaceous, with a slightly revolute margin and a prominent midrib
below. In transmitted light they show very numerous pellucid oil-glands.

The taste of the leaves of Pilocarpus is at first bitterish and
aromatic; they subsequently produce a tingling sensation in the mouth
and an abundant flow of saliva.

=Microscopic Structure=[450]—The oil-glands consist of large cells
of the same structure as those occurring generally in the leaves
of Rutaceæ, Aurantiaceæ, Myrtaceæ. In Pilocarpus they are largely
distributed in the tissue covered on both sides of the leaf by the
epidermis; the oil-cells are also abundantly met with in the petiole
and in the bark of the stems and branches.

=Chemical Composition=—The active principle of Jaborandi is the
alkaloid _Pilocarpine_, C₂₃H₃₅N₄O₄ + 4OH₂, discovered in 1875 by
Hardy. It is an amorphous soft mass, but yielding crystallized salts,
among which the hydrochlorate and the nitrate are now more frequently
used than the drug itself. The leaves afford about ½ per cent. of the
nitrate.

[446] Fig. in Bentley and Trimen, _Med. Plants_, part 32 (1878).

[447] Fig. by Engler in _Flora Brasil_. fasc. 65 (1874) tab. 30.
_Pilocarpus pauciflorus_ St. Hilaire (_Flora Brasiliæ meridionalis_, i.
1824. tab. 17) appears also to be very similar.

[448] Lib. iv. cap. 57, 59, and v. cap. 19, p. 310, of the work quoted
in the appendix.

[449] _Description des Plantes de l’Amérique_, 1693. 58. Pl. lxxv. and
lxxvi.

[450] Stiles, _Pharm. J._ vii. (1877) 629; also Lanessan’s French
translation of the _Pharmacographia_, i. (1878) 253.

The occurrence of another peculiar alkaloid in Pilocarpus has been
asserted, but not ultimately proved.

The leaves contain about ½ per cent. of essential oil, the prevailing
constituent of it being a dextrogyrate terpene, C₁₀H₁₆, boiling at
178°, which forms a crystallized compound C₁₀H₁₆ + 2HCl melting at
49°·5 C.

=Uses=—Pilocarpine being a powerful diaphoretic and sialagogue,
the leaves of Jaborandi are used to some extent in pharmaceutical
preparations.

=Other Kinds of Jaborandi=—This name, as above stated, has originally
been given to plants of the order Piperaceæ, some of which are still
known in Brazil under the name Jaborandi. The following may be quoted
as being used at least in that country: _Serronia Jaborandi_[451]
Gaudichaud, _Piper reticulatum_ L. (_Enckea_ Miquel), _Piper
citrifolium_ Lamarck (_Steffensia_ Kunth), _Piper nodulosum_ Link,
_Artanthe mollicoma_ Miq.

_Aubletia trifolia_[452] Richard (_Monniera_ L.) and _Xanthoxylum
elegans_ Engler, belonging to the same order as Pilocarpus itself, are
also sometimes called Jaborandi.

We are not aware that other leaves than those of Pilocarpus are
imported to some extent in Europe under the name of Jaborandi.




AURANTIACEÆ.


FRUCTUS LIMONIS.

_Lemon_; F. _Citron_, _Limon_; G. _Citrone_, _Limone_.

=Botanical Origin=—_Citrus Limonum_ Risso (_C. Medica_ var. β Linn.), a
small tree 10 to 15 feet in height, planted here and there in gardens
in many subtropical countries, but cultivated as an object of industry
on the Mediterranean coast between Nice and Genoa, in Calabria, Sicily,
Spain, and Portugal.

The tree which is supposed to represent the wild state of the lemon and
lime, and as it seems to us after the examination of numerous specimens
in the herbarium of Kew, of the citron (_Citrus Medica_ Risso) also,
is a native of the forests of Northern India, where it occurs in the
valleys of Kumaon and Sikkim.

The cultivated lemon-tree is of rather irregular growth, with foliage
somewhat pallid, sparse, and uneven, not forming the fine, close head
of deep green that is so striking in the orange tree. The young shoots
are of a dull purple; the flowers, which are produced all the year
except during the winter, and are in part hermaphrodite and in part
unisexual, have the corolla externally purplish; internally white, and
a delicate aroma distinct from that of orange blossom. The fruit is
pale yellow, ovoid, usually crowned by a nipple.

[451] Already known to Piso.

[452] The original Jaborandi of Piso, according to Peckolt.
Dragendorff’s _Jahresbericht_, 1875. 163.

=History=—The name of the lemon in Sanskrit is _Nimbuka_; in
Hindustani, _Limbu_, _Limu_, or _Ninbu_. It is probably originally a
Cashmere word, which was transferred to the Sanskrit in comparatively
modern times, not in the antiquity.[453] From these sounds the Arabians
formed the word _Limun_, which has passed into the languages of Europe.

The lemon was unknown to the inhabitants of ancient Greece and Rome;
but it is mentioned in the Book of Nabathæan Agriculture,[454] which
is supposed to date from the 3rd or 4th century of our era. The
introduction of the tree to Europe is due to the Arabians, yet at
what precise period is somewhat doubtful. _Arance_ and _Limone_ are
mentioned by an Arabic poet living in the 11th century, in Sicily,
quoted by Falcando.[455] The geographer Edrisi,[456] who resided at the
court of Roger II., king of Sicily, in the middle of the 12th century,
mentions the lemon (_limouna_) as a very sour fruit of the size of an
apple which was one of the productions of Mansouria on the Mahrân or
Indus; and he speaks of it in a manner that leads one to infer it was
not then known in Europe. This is the more probable from the fact that
there is no mention either of lemon or orange in a letter written A.D.
1239 concerning the cultivation of the lands of the Emperor Frederick
II. at Palermo,[457] a locality in which these fruits are now produced
in large quantity.

On the other hand the lemon is noticed at great length by Ibn Baytar
of Malaga, who flourished in the first half of the 13th century,
but of its cultivation in Spain at that period there is no actual
mention.[458] In 1369 at least citron trees, “arbores citronorum,”
were planted in Genoa,[459] and there is evidence that also the
lemon-tree was grown on the Riviera di Ponente about the middle of the
15th century, since _Limones_ and also _Citri_ are mentioned in the
manuscript _Livre d’Administration_ of the city of Savona, under date
1486.[460] The lemon was cultivated as early as 1494 in the Azores,
whence the fruit used to be largely shipped to England; but since the
year 1838 the exportation has totally ceased.[461]

=Description=—The fruit of _Citrus Limonum_ as found in the shops[462]
is from about 2 to 4 inches in length, egg-shaped with a nipple more
or less prominent at the apex; its surface, of a pale yellow, is even
or rugged, covered with a polished epidermis. The parenchyme within
the latter abounds in large cells filled with fragrant essential oil.
The roughness of the surface of the rind is due to the oil-cells. The
peel, which varies considerably in thickness but is never so thick as
that of the citron, is internally white and fibrous, and is adherent
to the pale yellow pulp. The latter is divided into 10 or 12 segments
each containing 2 or 3 seeds. It abounds in a pale yellow acid juice
having a pleasant sour taste and a slight peculiar odour quite distinct
from that of the peel. When removed from the pulp by pressure, the
juice appears as a rather turbid yellowish fluid having a sp. gr. which
varies from 1·040 to 1·045, and containing in each fluid ounce from 40
to 46 grains of citric acid, or about 9½ per cent.[463] In Italy all
the fine and perfect fruit is exported; the windfalls and the damaged
fruit are used for the production of the essential oil and the juice.
About 13,000 lemons of this kind yield one pipe (108 gallons) of raw
juice. Sicilian juice in November will contain about 9 ounces of citric
acid per gallon, but 6 ounces when afforded by the fruit collected in
April. The juice is boiled down in copper vessels, over an open fire,
till its specific gravity is about 1·239.[464] Lemon juice (_Succus
limonis_) for administration as a medicine should be pressed as wanted
from the recent fruit whenever the latter is obtainable.

[453] Dr. Rice in _New Remedies_, 1878, 263; also private information.

[454] Meyer, _Geschichte der Botanik_, iii. (1856) 68.

[455] Amari, _Storia dei Musulmani di Sicilia_, ii. (1858) 444.

[456] _Géographie d’Edrisi_, traduite par Jaubert, i. (1836) 162.

[457] Huillard-Bréholles, _Historia diplomatica Friderici secundi_,
Paris, v. (1857) 571.

[458] _Heil-und Nahrungsmittel von Ebn Baithar_, übersetzt von
Sontheimer, ii. (1842) 452.

[459] Belgrano, _Vita privata dei Genovesi_, Genova (1875) 158.

[460] Gallesio, _Traité du Citrus_ (1811) 89, 103.

[461] Consul Smallwood, in _Consular Reports_, Aug. 1873. 986.

[462] There are many kinds of lemon as well as of orange which are
never seen in commerce. Risso and Poiteau enumerate 25 varieties of
the former and 30 of the latter. See also Alfonso, _Coltivazione degli
Agrumi_, Palermo, 2nd edition, 1875.

[463] Stoddart, in _Pharm. Journ._ x. (1869) 203.

[464] R. Warington, _Pharm. Journ_. v. (1875) 385.

The peel (_Cortex limonis_) cut in somewhat thin ribbons from the fresh
fruit is used in pharmacy, and is far preferable to that sold in a
dried state.

=Microscopic Structure of the Peel.=—The epidermis exhibits numerous
stomata; the parenchyme of the pericarp encloses large oil-cells,
surrounded by small tabular cells. The inner spongy tissue is built up
of very remarkable branched cells, separated by large intercellular
spaces. A solution of iodine in iodide of potassium imparts to the
cell-walls a transient blue coloration. The outer layers of the
parenchymatous tissue contain numerous yellowish lumps of a substance
which assumes a brownish hue by iodine, and yields a yellow solution
if potash be added. Alkaline tartrate of copper is reduced by this
substance, which probably consists of hesperidin. There also occur
large crystals of oxalate of calcium, belonging to the monoclinic
system. The interior tissue is irregularly traversed by small vascular
bundles.

=Chemical Composition=—The peel of the lemon abounds in essential
oil, which is a distinct article of commerce, and will be described
hereafter.

Lemons, as well as other fruits of the genus _Citrus_, contain a bitter
principle, _Hesperidin_, of which E. Hoffmann[465] obtained 5 to 8
per cent. from unripe bitter oranges. He extracted them with dilute
alcohol, after they had previously been exhausted by cold water. The
alcohol should contain about 1 per cent. of caustic potash; the liquid
on cooling is acidulated with hydrochloric acid, when it yields a
yellowish crystalline deposit of hesperidin, which may be obtained
colourless and tasteless by recrystallization from boiling alcohol. By
dilute sulphuric acid (1 per cent.) hesperidin is broken up as follows:—

     C₂₂H₂₆O₁₂   =   C₁₆H₁₄O₆   +  C₆H₁₂O₆.
    Hesperidin.    Hesperetin.    Glucose.

Hesperidin is very little soluble even in boiling water or in ether,
but dissolves readily in hot acetic acid, also in alkaline solutions,
the latter then turning soon yellow and reddish. Pure hesperidin, as
presented to one of us by Hoffmann, darkens when it is shaken with
alcoholic perchloride of iron, and turns dingy blackish brown when
gently warmed with the latter.

[465] _Berichte der Deutschen Chemischen Gesellschaft_ (1876) 26, 685,
693.

_Hesperetin_ forms crystals melting at 223° C., soluble both in alcohol
or ether, not in water; they taste sweet. They are split up by potash
in Phloroglucin and _Hesperetic acid_, C₁₀H₁₀O₄.

On addition of ferric chloride, thin slices of the peel are darkened,
owing probably to some derivative of hesperidin, or to hesperidin
itself.

The name hesperidin had also been applied to _yellow_ crystals
extracted from the shaddock, _Citrus decumana_ L., the dried flowers
of which afford about 2 per cent. of that substance. It is, as
shown in 1879 by E. Hoffmann, quite different from hesperidin as
described above; he calls it _Naringin_ and assigns to it the formula
C₂₃H₂₆O₁₂+4OH₂. Naringin is readily soluble in hot water or in alcohol,
not in ether or chloroform. Its solutions turn brown-red on addition of
ferric chloride.

Lemon juice, some of the characters of which have been already noticed,
is an important article in a dietetic point of view, being largely
consumed on shipboard for the prevention of scurvy. In addition to
citric acid it contains 3 to 4 per cent. of gum and sugar, and 2·28 per
cent. of inorganic salts, of which according to Stoddart only a minute
proportion is potash. Cossa[466] on the other hand, who has recently
studied the products of the lemon tree with much care, has found that
the ash of dried lemon juice contains 54 per cent. of potash, besides
15 per cent. of phosphoric acid.

Stoddart has pointed out the remarkable tendency of citric acid to
undergo decomposition,[467] and has proved that in lemons kept from
February to July this acid generally decreases in quantity, at first
slowly, but afterwards rapidly, until at the end of the period it
entirely ceases to exist, having been all split up into glucose and
carbonic acid. At the same time the sp. gr. of the juice was found to
have undergone but slight diminution:—thus it was 1·044 in February,
1·041 in May, and 1·027 in July, and the fruit had hardly altered in
appearance. Lemon juice may with some precautions be kept unimpaired
for months or even years. Yet it is capable of undergoing fermentation
by reason of the sugar, gum, and albuminoid matters which it contains.

=Commerce=—Lemons are chiefly imported from Sicily, to a smaller extent
from the Riviera of Genoa and from Spain. From the published statistics
of trade, in which lemons are classed together with oranges under one
head, it appears that these fruits are being imported in increasing
quantities. The value of the shipments to the United Kingdom in 1872
(largely exceeding those of any previous year) was £1,154,270. Of this
sum, £986,796 represents the value of the oranges and lemons imported
from Spain, Portugal, the Canary Islands and Azores; £155,330 the
shipments of the same fruit from Italy; and £3,825 those from Malta.

Of concentrated _lemon juice_ there were exported in 1877 from
Messina 1,631,332 kilogrammes, valued at 2,446,996 lire. The value of
concentrated _lime juice_ exported in 1874 from Montserrat was £3,390.
From Dominica, 11,285 gallons, value £1,825, were shipped in 1875.

[466] _Gazetta Chimica Italiana_, ii. (1872) 385; _Journ. of Chem.
Soc._ xi (1873) 402.

[467] Stoddart’s statement that if potash be added to lemon juice,
_oxalic acid_ may be detected in the mixture after a few days, is not
supported by our observations.

=Uses=—Lemon peel is used in medicine solely as a flavouring
ingredient. Freshly prepared lemon juice is often administered with an
alkaline bicarbonate in the form of an effervescing draught, or in a
free state.

Concentrated _lemon juice_ is imported for the purpose of making citric
acid; it is derived not only from the lemon, but also, to a smaller
extent, from the lime and bergamot. _Lime juice_ of the West Indies is
chiefly used as a beverage; small quantities of it are also exported
for the manufacture of citric acid. The culture of _Citrus Limetta_
Risso, the _lime_, was introduced in Montserrat in 1852.


OLEUM LIMONIS.

_Oleum Limonum_; _Essential Oil or Essence of Lemon_; F. _Essence de
Citron_; G. _Citronenöl_.

=Botanical Origin=—_Citrus Limonum_ Risso (see p. 114).

=History=—The chemists of the 16th century were well acquainted with
the method of extracting essential oils by distillation. Besson in
his work _L’art et moyen parfaict de tirer huyles et eaux de tous
medicaments simples et oleogineux_, published at Paris in 1571,
mentions _lemon_-(citron) and orange-peel among the substances
subjected to this process. Giovanni Battista Porta,[468] a learned
Neapolitan writer, describes the method of preparing _Oleum ex
corticibus Citri_ to consist in removing the peel of the fruit with
a rasp and distilling it so comminuted with water; and adds that the
oils of lemon and orange may be obtained in the same manner. Essence
of lemon of two kinds, namely _expressed_ and _distilled_, was sold in
Paris in the time of Pomet, 1692.

=Production=—Essential oil of lemon is manufactured in Sicily, at
Reggio in Calabria, and at Mentone and Nice in France.

The lemons are used while still rather green and unripe, as being
richer in oil than when quite mature. Only the small and irregular
fruit, such as is not worth exporting, is employed for affording the
essence.

The process followed in Sicily and Calabria may be thus described;[469]
it is performed in the months of November and December.

[468] _Magiæ Naturalis libri xx._ Neapoli. 1589. 188.

[469] Through the kindness of Signor Mallandrino of Giampilieri near
Messina, I had the pleasure of seeing how the essence is made. Though
the time of my visit (13 May 1872) was not that of the manufacture,
Signor M. sent for one of his workmen, and having procured a few
lemons, set him to work on them in order that I might have ocular
demonstration of the process.—D. H.

The workman first cuts off the peel in _three_ thick longitudinal
slices, leaving the central pulp of a three-cornered shape with a
little peel at either end. This central pulp he cuts transversely in
the middle, throwing it on one side and the pieces of peel on the
other. The latter are allowed to remain till the next day and are then
treated thus: the workman seated holds in the palm of his left hand a
flattish piece of sponge, wrapping it round his forefinger. With the
other he places on the sponge one of the slices of peel, the outer
surface downwards, and then presses the zest-side (which is uppermost)
so as to give it for the moment a convex instead of a concave form.
The vesicles are thus ruptured, and the oil which issues from them is
received in the sponge with which they are in contact. Four or five
squeezes are all the workman gives to each slice of peel, which done
he throws it aside. Though each bit of peel has attached to it a small
portion of pulp, the workman contrives to avoid pressing the latter.
As the sponge gets saturated the workman wrings it forcibly, receiving
its contents in a coarse earthen bowl provided with a spout; in this
rude vessel, which is capable of holding at least three pints, the
oil separates from the watery liquid which accompanies it and is then
decanted.

The yield is stated to be very variable, 400 fruits affording 9 to 14
ounces of essence. The prisms of pulp and the exhausted pieces of peel
are submitted to pressure in order to extract from them lemon juice,
and are said to be also subjected to distillation. The foregoing is
termed the _sponge-process_; it is also applied to the orange. It
appears rude and wasteful, but when honestly performed it yields an
excellent product.

Essence of lemon is prepared at Mentone and Nice by a different method.
The object being to set free and to collect the oil contained in the
vesicles of the peel, an apparatus is employed, which may be thus
described:—a stout saucer or shallow basin of pewter, about 8½ inches
in diameter with a lip on one side for convenience of pouring. Fixed
in the bottom of this saucer are a number of stout, sharp, brass pins,
standing up about half an inch; the centre of the bottom is deepened
into a tube about an inch in diameter and five inches in length, closed
at its lower end. This vessel, which is called an _écuelle à piquer_,
has therefore some resemblance to a shallow, dish-shaped funnel, the
tube of which is closed below.

The workman takes a lemon in the hand, and rubs it over the sharp pins,
turning it round so that the oil-vessels of the entire surface may be
punctured. The essential oil which is thus liberated is received in the
saucer whence it flows down into the tube; and as this latter becomes
filled, it is poured into another vessel that it may separate from
the turbid aqueous liquid that accompanies it. It is finally filtered
and is then known as _Essence de Citron au zeste_. A small additional
produce is sometimes obtained by immersing the scarified lemons in warm
water and separating the oil which floats off.

A second kind of essence termed _Essence de Citron distillée_ is
obtained by rubbing the surface of fresh lemons, or of those which have
been submitted to the process just described, on a coarse grater of
tinned iron, by which the portion of peel richest in essential oil is
removed. This grated peel is subjected to distillation with water, and
yields a colourless essence of very inferior fragrance, which is sold
at a low price.

=Description=[470]—The oil obtained by the sponge-process and that of
the _écuelle à piquer_ are mobile liquids of a faint yellow colour, of
exquisite fragrance and bitterish aromatic taste.

[470] For specimens of the _Essence au zeste_ and of the _Essence
distillée_ of guaranteed purity we have to thank M. Médecin, distiller
of essences, Mentone; and Messrs. G. Pannucio e figli, for an authentic
sample of the essence made by the sponge process in their establishment
at Reggio. We have also had a small quantity prepared by the _écuelle_
by one of ourselves near Mentone, 15th June 1872.—D. H.

The different specimens which we have examined are readily miscible
with bisulphide of carbon, but dissolve sparingly in spirit of wine
(0·830). An equal weight of the oil and of spirit of wine forms a
turbid mixture. No peculiar coloration is produced by mixture with
perchloride of iron.

The oils are dextrogyre, but differ in their rotatory power, as may be
illustrated by the following results, which we obtained by examining
them in a column 50 millimetres long in the polaristrobometer of
Wild. The oil of Signori Panuccio, due to the sponge-process (p. 118,
note 2), deviated 20·9°, that of Monsieur Médecin (_Essence de Citron
au zeste_) obtained by the _éculle à piquer_ deviated 33·4° and his
distilled oil 28·3°.

=Chemical Composition=—The prevailing portion of most essential oils
of the _Aurantiaceæ_ agrees with the formula C₁₀H₁₆; the differences
which they exhibit chiefly concern their optical properties, odour, and
colour. The boiling point mostly varies from about 170° to 180° C., the
sp. gr. between 0·83 and 0·88. These oils are a mixture of isomeric
hydrocarbons, and also contain a small amount of cymene, C₁₀H₁₄, and of
oxygenated oils, not yet well known; of these we may infer the presence
either from analytical results or simply from the fact that the crude
oils are altered by metallic sodium. If they are purified by repeated
rectification over that metal, they are finally no longer altered by
it. Oils thus purified cease to possess their original fragrance, and
often resemble oil of turpentine, with which they agree in composition
and general chemical behaviour.

As to essential oil of lemons, its chief constituent is the terpene,
C₁₀H₁₆, which, like oil of turpentine, easily yields crystals of
terpin, C₁₀H₁₆ 3OH₂. There is further present, according to Tilden
(1879) another hydrocarbon, C₁₀H₁₆, which already boils at 160° C.,
whereas the foregoing boils at 176° C. Lastly a small amount of cymene
and of a compound acetic ether, C₂H₃O(C₁₀H₁₇O), would appear to occur
also in oil of lemons. The crude oil of lemons already yields the
crystalline compound C₁₀H₁₆ + 2HCl, when saturated with anhydrous
hydrochloric gas, whereas by the same treatment oil of turpentine
affords the solid compound C₁₀H₁₆ + HCl.

Essential oil of lemons (not the distilled) when long kept deposits a
greasy mass, from which we have obtained small crystals apparently of
_Bergaptene_ (p. 123).

=Commerce=—Essence of lemons is shipped chiefly from Messina and
Palermo, packed in copper bottles called in Italian _ramiere_ and by
English druggists “_jars_” holding 25 to 50 kilo. or more; sometimes in
tin bottles of smaller size. The quantity of essences of lemon, orange
and bergamot exported from Sicily in 1871 was 368,800 lb., valued at
£144,520, of which about two-thirds were shipped to England.[471]
In 1877 the export of these essential oils from Messina amounted to
306,948 kilogrammes, valued at 6,130,960 lire.

[471] Consul Dennis, _On the Commerce, &c. of Sicily in 1869, 1870,
1871_. _Reports from H.M. Consuls_. No. 4. 1873.

=Uses=—Essence of lemon is used in perfumery, and as a flavouring
ingredient; and though much sold by druggists is scarcely employed in
medicine.

=Adulteration=—Few drugs are more rarely to be found in a state of
purity than essence of lemon. In fact it is stated that almost all that
comes into the market is more or less diluted with oil of turpentine
or with the cheaper _distilled_ oil of lemons. Manufacturers of the
essence complain that the demand for a cheap article forces them to
this falsification of their product.


OLEUM BERGAMOTTÆ.

_Oleum Bergamii_; _Essence or Essential Oil of Bergamot_; F. _Essence
de Bergamotte_; G. _Bergamottöl_.

=Botanical Origin=—_Citrus Bergamia_ var. _vulgaris_ Risso et
Poiteau,[472] a small tree closely resembling in flowers and foliage
the Bitter Orange. Its fruit is 2½ to 3 inches in diameter, nearly
spherical, or slightly pear-shaped, frequently crowned by the
persistent style; it is of a pale golden yellow like a lemon,[473] with
the peel smooth and thin, abounding in essential oil of a peculiar
fragrance; the pulp is pale yellowish green, of a bitterish taste, and
far less acid than that of the lemon.

The tree is cultivated at Reggio in Calabria, and is unknown in a wild
state.

=History=—The bergamot is one of the cultivated forms which abound in
the genus _Citrus_, and which constitute the innumerable varieties of
the orange, lemon and citron. Whether it is most nearly related to the
lemon or to the orange is a point discussed as early as the beginning
of the last century. Gallesio[474] remarks that it so evidently
combines the characters of the two that it should be regarded as a
hybrid between them. The bergamot first appeared in the latter part
of the 17th century. It is not mentioned in the grand work on orange
trees of Ferrari,[475] published at Rome in 1646, nor in the treatise
of Commelyn[476] (1676), nor in the writings of Lanzoni (1690),[477]
or La Quintinie (1692).[478] So far as we know, it is first noticed
in a little book called _Le Parfumeur François_, printed at Lyons in
1693. The author who calls himself _Le Sieur Barbe, parfumeur_, says
that the _Essence de Cedra ou Bergamotte_ is obtained from the fruits
of a lemon-tree which has been grafted on the stem of a bergamot pear;
he adds that it is got by squeezing small bits of the peel with the
fingers in a bottle or globe large enough to allow the hand to enter.

[472] _Histoire naturelle des Orangers_, Paris, 1818. p. 111. tab.
53, or the same work, new edition, by Dubreuil, 1873, p. 82. We
accept the name given by these authors for the sake of convenience
and definiteness, and not because we concur in their opinion that the
Bergamot deserves to be ranked as a distinct botanical species.

[473] Fig. in Bentley and Trimen, _Med. Plants_, part 31.

[474] _Traité du Citrus_, 1811. 118.

[475] _Hesperides, seu de malorum, aureorum cultura et usu_.

[476] _Nederlantze Hesperides_, Amsterd. 1676. fol. (an English
translation in 1683).

[477] _Citrologia_, Ferrariæ, 1690.

[478] _Instruction pour les Jardins fruitiers ... avec un traité des
Orangers_, ed. 2, 1692.

Volkamer of Nuremberg, who produced a fine work on the Citron tribe in
1708, has a chapter on the _Limon Bergamotta_, which he describes as
_gloria limonum et fructus inter omnes nobilissimus_. He states that
the Italians prepare from it the finest essences, which are sold at a
high price.[479]

But, as shown by one of us,[480] the essential oil of bergamot had
already, in 1688, a place among the stores of an apothecary of the
German town of Giessen.

The name Bergamotta was originally applied to a large kind of pear,
called in Turkish “beg-ârmûdî,” _i.e._ prince’s pear.[481]

=Production=—The bergamot is cultivated at Reggio, on low ground near
the sea, and in the adjacent villages. The trees are often intermixed
with lemon and orange trees, and the soil is well irrigated and cropped
with vegetables.

The essential oil (_Oleum Bergamottæ_) is obtained from the full-grown
but still unripe and more or less green fruits, gathered in the
months of November and December. They are richer in oil than any one
of the allied fruits. It was formerly made like that of lemon by the
sponge-process, but during the last 20 years this method has been
generally superseded by the introduction of a special machine for
the extraction of the essential oil. In this machine the fruits are
placed in a strong, saucer-like, metallic dish, about 10 inches in
diameter, having in the centre a raised opening which with the outer
edge forms a broad groove or channel; the dish is fitted with a cover
of similar form. The inner surface both of the dish and cover is
rendered rough by a series of narrow, radiating metal ridges of blades
which are about ¼ of an inch high and resemble the backs of knifes.
The dish is also furnished with some small openings to allow of the
outflow of essential oil; and both dish and cover are arranged in a
metallic cylinder, placed over a vessel to receive the oil. By a simple
arrangement of cog-wheels moved by a handle, the cover, which is very
heavy, is made to revolve rapidly over the dish, and the fruit lying
in the groove between the two is carried round, and at the same time
is subjected to the action of the sharp ridges, which, rupturing the
oil-vessels, cause the essence to escape, and set it free to flow out
by the small openings in the bottom of the dish. The fruits are placed
in the machine, 6, 8, or more at a time, according to their size, and
subjected to the rotatory action above described for about half a
minute, when the machine is stopped, they are removed, and fresh ones
substituted. About 7,000 fruits can thus be worked in one of these
machines in a day. The yield of oil is said to be similar to that of
lemon, namely 2½ to 3 ounces from 100 fruits.

[479] _Hesperides Norimbergenses_, 1713. lib. 3. cap. 26. and p. 156 b.
(We quote from the Latin edition.)

[480] Flückiger, _Documente zur Geschichte der Pharmacie_, Halle, 1876.
72.

[481] Information, for which I am indebted to Dr. Rice.—The name has no
reference to the town of Bergamo, where bergamots cannot succeed.—F. A.
F.

Essence of bergamot made by the machine is of a greener tint than that
obtained by the old sponge-process. During some weeks after extraction
it gradually deposits a quantity of white greasy matter (bergaptene),
which, after having been exhausted as much as possible by pressure, is
finally subjected to distillation with water in order to separate the
essential oil it still contains.

The fruits from which the essence has been extracted are submitted to
pressure, and the juice, which is much inferior in acidity to lemon
juice, is concentrated and sold for the manufacture of citric acid.
Finally, the residue from which both essence and juice have been
removed, is consumed as food by oxen.

=Description=[482]—Essential oil of bergamot is a thin and mobile fluid
of peculiar and very fragrant odour, bitterish taste, and slightly
acid reaction. It has a pale greenish yellow tint, due to traces of
chlorophyll, as may be shown by the spectroscope. Its sp. gr. is 0·86
to 0·88; its boiling point varies from 183° to 195° C.

The oil is miscible with spirit of wine (0·83 sp. gr.), absolute
alcohol, as well as with crystallizable acetic acid. Four parts
dissolve clearly one part of bisulphide of carbon, but the solution
becomes turbid if a larger proportion of the latter is added.
Bisulphide of carbon itself is incapable of dissolving clearly any
appreciable quantity of the oil. A mixture of 10 drops of the oil, 50
drops of bisulphide of carbon and one of strong sulphuric acid has
an intense yellow hue. Perchloride of iron imparts to bergamot oil
dissolved in alcohol a dingy brown colour.

Panuccio’s oil of bergamot examined in the same way as that of lemon
(p. 120) deviates 7° to the right, and has therefore a dextrogyre
power very inferior to that of other oils of the same class.[483] But
it probably varies in this respect, for commercial specimens which we
judged to be of good quality deviated from 6·8° to 10·4° to the right.

=Chemical Composition=—If essential oil of bergamot is submitted to
rectification, the portions that successively distill over do not
accord in rotatory power or in boiling point, a fact which proves it to
be a mixture of several oils, as is further confirmed by analysis. It
appears to consist of hydrocarbons, C₁₀H₁₆, and their hydrates, neither
of which have as yet been satisfactorily isolated. Oil of bergamot,
like that of turpentine, yields crystals of the composition C₁₀H₁₆ +
3H₂O, if 8 parts are allowed to stand some weeks with 1 part of spirit
of wine, 2 of nitric acid (sp. gr. 1·2) and 10 of water, the mixture
being frequently shaken. No solid compound is produced by saturating
the oil with anhydrous hydrochloric gas.

The greasy matter that is deposited from oil of bergamot soon after
its extraction, and in small quantity is often noticeable in that
of commerce, is called _Bergaptene_ or _Bergamot Camphor_. We have
obtained it in fine, white, acicular crystals, neutral and inodorous,
by repeated solution in spirit of wine. Its composition according
to the analysis of Mulder (1837) and of Ohme (1839) answers to the
formula C₉H₆O₃, which in our opinion requires further investigation.
Crystallized bergaptene is abundantly soluble in chloroform, ether, or
bisulphide of carbon; the alcoholic solution is not altered by ferric
salts.

[482] The characters are taken from some Essence of Bergamot presented
to one of us (15 May 1872) as a type-sample by Messrs. G. Panuccio e
figli, manufacturers of essences at Reggio and also large cultivators
of the bergamot orange.

[483] See however _Oleum Neroli_, p. 127.

=Commerce=—Essence of bergamot, as it is always termed in trade, is
chiefly shipped from Messina and Palermo in the same kind of bottles as
are used for essence of lemon.

=Uses=—Much employed in perfumery, but in medicine only occasionally
for the sake of imparting an agreeable odour to ointments.

=Adulteration=—Essence of bergamot, like that of lemon, is extensively
and systematically adulterated, and very little is sent into the market
entirely pure. It is often mixed with oil of turpentine, but a finer
adulteration is to dilute it with essential oil of the leaves or with
that obtained by distillation of the peel or of the residual fruits.
Some has of late been adulterated with petroleum.

The optical properties, as already mentioned, may afford some
assistance in detecting fraudulent admixtures, though as regards oil of
turpentine it must be borne in mind that there are _levogyre_ as well
as _dextrogyre_ varieties. This latter oil and likewise that of lemon
is less soluble in spirit of wine than that of bergamot.


CORTEX AURANTII.

_Bitter Orange Peel_; F. _Ecorce ou Zestes d’Oranges amères_; G.
_Pomeranzenschale_.

=Botanical Origin=—_Citrus vulgaris_ Risso (_C. Aurantium_ var. _a
amara_ Linn., _C. Bigaradia_ Duhamel).

The Bitter or Seville or Bigarade Orange, _Bigaradier_[484] of the
French, is a small tree extensively cultivated in the warmer parts of
the Mediterranean region, especially in Spain, and existing under many
varieties.

Northern India is the native country of the orange tree. In Gurhwal,
Sikkim, and Khasia there occurs a wild orange which is the supposed
parent of the cultivated orange, whether Sweet or Bitter.

The Bitter Orange reproduces itself from seed, and is regarded, at
least by cultivators, as quite distinct from the Sweet Orange, from
which however it cannot be distinguished by any important botanical
characters. Generally speaking, it differs from the latter in having
the fruit rugged on the surface, of a more deep or reddish-orange hue,
with the pulp very sour and bitter. The peel, as well as the flowers
and leaves, are more aromatic than the corresponding parts of the Sweet
Orange, and the petiole is more broadly winged.

=History=—The orange was unknown to the ancient Greeks and Romans;
and its introduction to Europe is due to the Arabs, who, according to
Gallesio,[485] appear to have established the tree first in Eastern
Africa, Arabia, and Syria, whence it was gradually conveyed to Italy,
Sicily, and Spain. In the opinion of the writer just quoted, the bitter
orange was certainly known at the commencement of the 10th century to
the Arabian physicians, one of whom, Avicenna,[486] employed its juice
in medicine.

[484] From the Basque “bizarra” = beard (Rice, _New Remedies_, 1878.
231), or from the Sanskrit Bijouri.

[485] _Traité du Citrus_, Paris, 1811. 222.

[486] _Opera_, ed. Valgrisi 1564. lib. v. sum. 1. tract. 9. p. 289.—The
passage, which is the following, seems rather inconclusive:—“ ... succi
acetositatis citri et succi acetositatis citranguli.”

There is strong evidence to show that the orange first cultivated in
Europe was the _Bitter Orange_ or _Bigarade_. The orange tree at Rome,
said to have been planted by St. Dominic about A.D. 1200, and which
still exists at the monastery of St. Sabina, bears a _bitter_ fruit;
and the ancient trees standing in the garden of the Alcazar at Seville
are also of this variety. Finally, the oranges of Syria (_ab indigenis_
Orenges _nuncupati_) described by Jacques de Vitri, Bishop of Acon
(_ob._ A.D. 1214) were _acidi seu pontici saporis_.[487]

The Sweet Orange began to be cultivated about the middle of the 15th
century, having been introduced from the East by the Portuguese. It has
probably long existed in Southern China, and may have been taken thence
to India. In the latter country there are but few districts in which
its cultivation is successful, and the Bitter Orange is hardly known at
all. The name it has long borne of _China_[488] or _Portugal Orange_
indicates what has been the usual opinion as to its origin. It probably
alludes more exactly to a superior variety brought about 1630 from
China to Portugal.[489]

One of the first importations of oranges into England occurred in A.D.
1290, in which year a Spanish ship came to Portsmouth, of the cargo of
which the queen of Edward I. bought one frail of Seville figs, one of
raisins or grapes, one bale of dates, 230 pomegranates, 15 citrons, and
7 _oranges_ (“_poma de orenge_”).[490]

=Description=—The Bitter Orange known in London as the _Seville
Orange_ is a globular fruit, resembling in size, form, and structure
the common Sweet Orange, but having the peel much rougher, and when
mature of a somewhat deeper hue. The pulp of the fruit is filled with
an acid bitter juice. The ripe fruit is imported into London; the
peel is removed from it with a sharp knife in one long spiral strip,
and quickly dried, or it is sold in the fresh state. It is the more
esteemed when cut thin, so as to include as little as possible of the
white inner layer.

Well-dried orange peel should be externally of a bright tint and white
on its inner surface; it should have a grateful aromatic smell and
bitter taste. The peel is also largely imported into London ready
dried, especially from Malta. We have observed it from this latter
place of three qualities, namely in elliptic pieces or quarters, in
broad curled strips, and lastly a very superior kind, almost wholly
free from white zest, in strips less than ⅛ of an inch in width, cut
apparently by a machine. Such needless subdivision as this last has
undergone must greatly favour an alteration and waste of the essential
oil. Foreign-dried orange peel fetches a lower price than that dried in
England.

=Microscopic Structure=—There is no difference between the tissues of
this drug and those of lemon peel.

[487] Vitriaco, _Hist. orient. et occident._ 1597. cap. 86.

[488] Hence the Dutch _Sinaasappel_ or _Appelsina_ and the German
_Apfelsine_.

[489] Goeze, _Beitrag zur Kenntniss der Orangengewächse_, Hamburg,
1874. 29.

[490] _Manners and Household Expenses of England in the 13th and 15th
centuries_, Lond. (Roxburghe Club) 1841. xlviii.

=Chemical Composition=—The essential oil to which the peel of the
orange owes its fragrant odour, is a distinct article of commerce, and
will be noticed hereafter under a separate head. The other constituents
of the peel probably agree with those of lemon peel. The substance
mentioned under the name of _Hesperidin_ (p. 116) particularly abounds
in unripe bitter oranges.

=Uses=—Bitter orange peel is much used in medicine as an aromatic tonic.


OLEUM NEROLI.

_Oleum Aurantii florum_; _Oil or Essence of Neroli_; F. _Essence de
Néroli_; G. _Neroliöl_.

=Botanical Origin=—_Citrus vulgaris_ Risso. (See page 124.)

=History=—Porta, the Italian philosopher of the 16th century referred
to (p. 118), was acquainted with the volatile oil of the flowers of
the citron tribe (“_Oleum ex citriorum floribus_”), which he obtained
by the usual process of distillation, and describes as possessing
the most exquisite fragrance. That distilled from orange flowers
acquired a century later (1675-1685) the name of _Essence of Neroli_
from Anne-Marie de la Trémoille-Noirmoutier, second wife of Flavio
Orsini, duke of Bracciano and prince of Nerola or Neroli. This lady
employed it for the perfuming of gloves, hence called in Italy _Guanti
di Neroli_.[491] It was known in Paris to Pomet, who says[492] the
perfumers have given it the name of _Neroli_, and that it is made in
Rome and in Provence.

=Production=—Oil of Neroli is prepared from the fresh flowers of the
Bigarade or Bitter Orange by the ordinary process of distillation with
water, conducted in small copper stills. The flowers of all the allied
plants are far less aromatic. The water which distills over with the
oil constitutes, after the removal of the latter from its surface, the
_Orange Flower Water_ (_Aqua aurantii florum vel Aqua Naphæ_)[493] of
commerce. The manufacture is carried on chiefly in the south of France
at Grasse, Cannes, and Nice. The yield is about 0·6 to 0·7 per cent. of
oil from fresh flowers, as stated by Poiteau et Risso.[494] The flowers
of the sweet orange afford but half that amount of oil.

=Description and Chemical Composition=—Oil of Neroli as found in
commerce is seldom pure, for it generally contains an admixture of the
essential oil of orange-leaf called _Essence of Petit Grain_.

By the kind assistance of Mr. F. G. Warrick of Nice, we have obtained a
sample of Bigarade Neroli of guaranteed purity, to which the following
observations relate. It is of a brownish hue, most fragrant odour,
bitterish aromatic taste, and is neutral to test-paper. Its sp. gr.
at 11° C. is 0·889. When mixed with alcohol, it displays a bright
violet fluorescence, quite distinct from the blue fluorescence of a
solution of quinine. In oil of Neroli the phenomenon may be shown most
distinctly by pouring a little spirit of wine on to the surface of
the essential oil, and causing the liquid to gently undulate. The oil
is but turbidly miscible with bisulphide of carbon. It assumes a very
pure, intense, and permanent crimson hue if shaken with a saturated
solution of bisulphide of sodium. Examined in a column of 100 mm. we
observed the oil to deviate the ray of polarized light 6° to the right.

[491] Menagio, _Origini della Lingua Italiana_, 1685; _Dict. de
Trévoux_, Paris, vi. (1771) 178.—The town of Nerola is about 16 miles
north of Tivoli.

[492] _Histoire des Drogues_, 1694. 234. ii.

[493] Naphé or Naphore—according to Poiteau et Risso, _Hist. Nat. des
Orangers_ 1873. 211, these names perhaps originated in Languedoc.

[494] _L. c._ 211.

Subjected to distillation, the larger part of the oil passes over at
185°-195° C.; we found this portion to be colourless, yet to display in
a marked manner the violet fluorescence and also to retain the odour of
the original oil. The portion remaining in the retort was mixed with
about the same volume of alcohol (90 per cent.) and some drops of water
added, yet not sufficient to occasion turbidity. A very small amount
of the crystalline _Neroli Camphor_ then made its appearance, floating
on the surface of the liquid; by re-solution in boiling alcohol it was
obtained in crystals of rather indistinct form. The redistilled oil
gave no camphor whatever.

Neroli Camphor was first noticed by Boullay in 1828. According to
our observations it is a neutral, inodorous, tasteless substance,
fusible at 55° C., and forming on cooling a crystalline mass. The
crystallization should be effected by cooling the hot alcoholic
solution, no good crystals being obtainable by slow evaporation or by
sublimation. The produce was extremely small, about 60 grammes of oil
having yielded not more than 0·1 gramme. Perhaps this scantiness of
produce was due to the oil being a year and a half old, for according
to Plisson[495] the camphor diminishes the longer the oil is kept.[496]
We were unable to obtain any similar substance from the oils of
bergamot, petit grain, or orange peel.

_Orange Flower Water_ is a considerable article of manufacture among
the distillers of essential oils in the south of Europe, and is
imported thence for use in pharmacy. According to Boullay[497] it is
frequently acid to litmus when first made,—is better if distilled in
small than in large quantities, and if made from the petals _per se_,
rather than from the entire flowers. He also states that only 2 lb. of
water should be drawn from 1 lb. of flowers, or 3 lb. if petals alone
are placed in the still. As met with in commerce, orange flower water
is colourless or of a faintly greenish yellow tinge, almost perfectly
transparent, with a delicious odour and a bitter taste. Acidulated with
nitric acid, it acquires a pinkish hue more or less intense, which
disappears on saturation by an alkali.

=Uses=—Oil of Neroli is consumed almost exclusively in perfumery.
Orange flower water is frequently used in medicine to give a pleasant
odour to mixtures and lotions.

=Adulteration=—The large variation in value of oil of Neroli as shown
by price-currents[498] indicates a great diversity of quality. Besides
being very commonly mixed, as already stated, with the distilled oil
of the leaves (_Essence de Petit Grain_)[499], it is sometimes reduced
by addition of the less fragrant oil obtained from the flowers of
the Portugal or Sweet Orange. In some of these adulterations we must
conclude that orange flower water participate: metallic contamination
of the latter is not unknown.

[495] _Journ. de Pharm._ xv. (1829) 152.

[496] Yet we extracted it from an old sample labelled “_Essence de
Néroli Portugal—Méro._”

[497] _Bulletin de Pharm._, i. (1809) 337-341.

[498] Thus in the price-list of a firm at Grasse, Neroli is quoted as
of _four_ qualities, the lowest or “commercial” being less than half
the price of the finest.

[499] We have been informed on good authority that the Neroli commonly
sold contains ⅜ of Essence of Petit Grain, and ⅛ of Essence of
Bergamot, the remaining ⁴/₈ being true Neroli.

Other Products of the genus Citrus.

=Essence or Essential Oil of Petit Grain=—was originally obtained by
subjecting little immature oranges to distillation (Pomet—1692); but
it is now produced, and to a large extent, by distillation of the
leaves and shoots either of the Bigarade or Bitter Orange, or of the
Portugal or Sweet Orange. The essence of the former is by far the
more fragrant, and commands double the price. Poiteau and Risso[500]
state that the leaves of the Brigaradier with bitter fruit are by far
the richest in essential oil among all the allied leaves; they are
obtained in the lemon-growing districts of the Mediterranean where
the essence is manufactured. Lemon-trees being mostly grafted on
orange-stocks, the latter during the summer put forth shoots, which
are allowed to grow till they are often some feet in length. The
cultivator then cuts them off, binds them in bundles, and conveys them
to the distiller of _Petit Grain_. The strongest shoots are frequently
reserved for walking-sticks. The leaves of the two sorts of orange are
easily distinguished by their smell when crushed. Essence of Petit
Grain, which in odour has a certain resemblance to Neroli, is used in
perfumery and especially in the manufacture of Eau de Cologne.

According to Gladstone (1864) it consists mainly of a hydrocarbon
probably identical with that from oil of Neroli.

=Essential Oil of Orange Peel=—is largely made at Messina and also
in the south of France. It is extracted by the sponge-, or by the
_écuelle_-process, and partly from the Bigarade and partly from the
Sweet or Portugal Orange, the scarcely ripe fruit being in either
case employed. The oil made from the former is much more valuable
than that obtained from the latter, and the two are distinguished in
price-currents as _Essence de Bigarade_ and _Essence de Portugal_.

These essences are but little consumed in England, in liqueur-making
and in perfumery. For what is known of their chemical nature, the
reader can consult the works named at foot[501].

=Essence of Cedrat=—The true Citron or Cedrat tree is _Citrus medica_
Risso, and is of interest as being the only member of the Orange tribe
the fruit of which was known in ancient Rome. The tree itself, which
appears to have been cultivated in Palestine in the time of Josephus,
was introduced into Italy in about the 3rd century. In A.D. 1003 it
was much grown at Salerno near Naples, whence its fruits were sent as
presents to the Norman princes[502].

[500] _Loc. c._, edition of 1873. 211.

[501] Gmelin, _Chemistry_, xiv. (1860) 305. 306: Gladstone, _Journ.
of Chem. Soc._ xvii. (1864) 1: Wright (and Piesse) in _Yearbook of
Pharmacy_, 1871. 546; 1873. 518; _Journ. of Chem. Soc._ xi. (1873)
552, &c. We may moreover point out the existence of a crystallized
constituent of the oil of orange peel from the island of Curaçao. It
was noticed as long ago as the year 1771 by Gaubius: “Sal aromaticus,
nativus, ex oleo corticum mali aurei Curassavici,” in his book,
“Adersariorum varii argumenti, lib. unus.” Leidae, 1771. 27.

[502] Gallesio, _Traité du Citrus_, 1811. 222.

At the present day, the citron appears to be nowhere cultivated
extensively, the more prolific lemon tree having generally taken its
place. It is however scattered along the Western Riviera, and is also
grown on a small scale about Pizzo and Paola on the western coast of
Calabria, in Sicily, Corsica, and Azores. Its fruits, which often weigh
several pounds, are chiefly sold for being candied. For this purpose
the peel, which is excessively thick, is salted and in that state
shipped to England and Holland. The fruit has a very scanty pulp[503].

Essence of Cedrat which is quoted in some price-lists may be prepared
from the scarcely ripe fruit by the sponge-process; but as it is more
profitable to export the fruit salted, it is very rarely manufactured,
and that which bears its name is for the most part fictitious.


FRUCTUS BELÆ.

_Bela_; _Bael Fruit_, _Indian Bael_, _Bengal Quince_.

=Botanical Origin=—_Ægle Marmelos_[504] Correa (_Cratæva Marmelos_ L.),
a tree found in most parts of the Indian peninsula, which is often
planted in the neighbourhood of temples, being esteemed sacred by the
Hindus. It is truly wild in the forests of the Coromandel Ghâts and
of the Western Himalaya, ascending often to 4,000 feet and growing
gregarious when wild.

It attains a height of 30-40 feet, is usually armed with strong sharp
thorns and has trifid leaves, the central leaflet being petiolate and
larger than the lateral. The fruit is a large berry, 2 to 4 inches in
diameter, variable in shape, being spherical or somewhat flattened like
an orange, ovoid, or pyriform[505], having a smooth hard shell; the
interior divided into 10-15 cells each containing several woolly seeds,
consists of a mucilaginous pulp, which becomes very hard in drying. In
the fresh state the fruit is very aromatic, and the juicy pulp which it
contains has an agreeable flavour, so that when mixed with water and
sweetened, it forms a palatable refrigerant drink. The fruit is never
eaten as dessert, though its pulp is sometimes made into a preserve
with sugar.

The fruit of the wild tree is described as small, hard, and
flavourless, remaining long on the tree. The bark of the stem and root,
the flowers and the expressed juice of the leaves are used in medicine
by the natives of India.

=History=—The tree under the name of _Bilva_[506] is constantly alluded
to as an emblem of increase and fertility in ancient Sanskrit poems,
some of which as the Yajar Veda are supposed to have been written not
later than 1000 B.C.—Constantinus Africanus was acquainted with the
fruit under notice.

[503] Oribasius accurately describes the citron as a fruit consisting
of three parts, namely a central acid pulp, a thick and fleshy zest and
an aromatic outer coat.—_Medicinalia collecta_, lib. i. c. 64.

[504] _Ægle_, one of the Hesperides.—_Marmeloes_ from the Portuguese
_marmelo_, a quince.—Fig. in Bentley and Trimen, part 11.

[505] In the Botanical Garden of Buitenzorg in Java, three varieties
are grown, namely—_fructibus oblongis_, _fructibus subglobosis_, and
_macrocarpa_.

[506] We are indebted to Professor Monier Williams of Oxford for
pointing out to us many references to _Bilva_ in the Sanskrit writings.

Garcia de Orta, who resided in India as physician to the Portuguese
viceroy at Goa in the 16th century, wrote an account of the fruit
under the name of _Marmelos de Benguala_ (Bengal Quince) _Cirifole_ or
_Beli_[507], describing its use in dysentery.

In the following century it was noticed by Bontius, in whose writings
edited by Piso[508] there is a bad figure of the tree as _Malum
Cydonium_. It was also figured by Rheede,[509] and subsequently under
the designation of _Bilack_ or _Bilack tellor_ by Rumphius.[510] The
latter states that it is indigenous to Gujarat, the eastern parts of
Java, Sumbawa and Celebes, and that it has been introduced into Amboina.

But although _Ægle Marmelos_ has thus been long known and appreciated
in India, the use of its fruit as a medicine attracted no attention in
Europe till about the year 1850. The dried fruit which has a place in
the _British Pharmacopœia_ is now not unfrequently imported.

=Description=—We have already described the form and structure of the
fruit, which for medicinal use should be dried when in a half ripe
state. It is found in commerce in dried slices having on the outer side
a smooth greyish shell enclosing a hard, orange or red, gummy pulp in
which are some of the 10 to 15 cells existing in the entire fruit. Each
cell includes 6 to 10 compressed oblong seeds nearly 3 lines in length,
covered with whitish woolly hairs. When broken the pulp is seen to
be nearly colourless internally, the outside alone having assumed an
orange tint. The dried pulp has a mucilaginous, slightly acid taste,
without aroma, astringency, or sweetness.

There is also imported Bael fruit which has been collected when
ripe, as shown by the well-formed seeds. Such fruits arrive broken
irregularly and dried, or sawn into transverse slices and then dried,
or lastly entire, in which case they retain some of their original
fragrance resembling that of elemi.

=Microscopic Structure=—The rind of the fruit is covered with a strong
cuticle, and further shows two layers, the one exhibiting not very
numerous oil-cells, and the other an inner made up of sclerenchyme. The
tissue of the pulp, which, treated with water, swells into an elastic
mass, consists of large cells with considerable cavities between them.
The seeds when moistened yield an abundance of mucilage nearly in the
same way as White Mustard or Linseed. In the epidermis of the seeds
certain groups of cells are excessively lengthened, and thus constitute
the curious woolly hairs already noticed. They likewise afford mucilage
in the same way as the seed itself.

=Chemical Composition=—We are unable to confirm the remarkable analyses
of the drug alluded to in the _Pharmacopœia of India_;[511] nor can we
explain by any chemical examination upon what constituent the alleged
medicinal efficacy of bael depends.

[507] _Sirí-phal_ and _Bel_ are Hindustani names.—See also Flückiger,
_Documente_, 29.

[508] _De Indiæ re nat. et med._ 1658, lib. vi. c. 8.

[509] _Hort. Malab._ iii. (1682) tab. 37 (Covalam).

[510] _Herb. Amb._ i. tab. 81.

[511] Edition 1868, pp. 46 and 441.

The pulp moistened with cold water yields a red liquid containing
chiefly mucilage, and (probably) pectin which separates if the liquid
is concentrated by evaporation. The mucilage may be precipitated by
neutral acetate of lead or by alcohol, but is not coloured by iodine.
It may be separated by a filter into a portion truly soluble (as
proved by the addition of alcohol or acetate of lead), and another,
comprehending the larger bulk, which is only swollen like tragacanth,
but is far more glutinous and completely transparent.

Neither a per-nor a proto-salt of iron shows the infusion to contain
any appreciable quantity of tannin,[512] nor is the drug in any sense
possessed of astringent properties.

=Uses=—Bael is held in high repute in India as a remedy for dysentery
and diarrhœa; at the same time it is said to act as a laxative where
constipation exists.

=Adulteration=—The fruit of _Feronia Elephantum_ Correa, which has a
considerable external resemblance to that of _Ægle Marmelos_ and is
called by Europeans _Wood Apple_, is sometimes supplied in India for
bael. It may be easily distinguished: it is _one-celled_ with a large
five-lobed cavity (instead of 10 to 15 cells) filled with numerous
seeds. The tree has pinnate leaves with 2 or 3 pairs of leaflets. We
have seen _Pomegranate Peel_ offered as _Indian Bael_.[513]




SIMARUBEÆ.


LIGNUM QUASSIÆ.

_Quassia_, _Quassia Wood_, _Bitter Wood_; F. _Bois de Quassia de la
Jamaïque_, _Bois amer_; G. _Jamaica Quassiaholz_.

=Botanical Origin=—_Picræna excelsa_ Lindl. (_Quassia excelsa_ Swartz,
_Simaruba excelsa_ DC., _Picrasma excelsa_ Planchon), a tree 50 to 60
feet in height, somewhat resembling an ash and having inconspicuous
greenish flowers and black shining drupes the size of a pea. It is
common on the plains and lower mountains of Jamaica, and is also found
in the islands of Antigua and St. Vincent. It is called in the West
Indies _Bitter Wood_ or _Bitter Ash_.

=History=—Quassia wood was introduced into Europe about the middle
of the last century. It was derived from _Quassia amara_ L., a shrub
or small tree with handsome crimson flowers, belonging to the same
order, native of Panama, Venezuela, Guiana, and Northern Brazil. It
was subsequently found that the _Bitter Wood_ of Jamaica which Swartz
and other botanists referred to the same genus, possessed similar
properties, and as it was obtainable of much larger size, it has since
the end of the last century been generally preferred. The wood of _Q.
amara_, called _Surinam Quassia_, is however still used in France and
Germany.[514]

[512] We are thus at variance with Collas of Pondichéry, who attributes
to the ripe fruit 5 _per cent. of tannin_.—_Hist. nat. etc. du Bel ou
Vilva_ in _Revue Coloniale_, xvi. (1856) 220-238.

[513] 40 bags in a drug sale, 8th May, 1873.

[514] The _Pharmacopœa Germanica_ of 1872 expressly forbids the use of
the wood of _Picræna_ in place of _Quassia_.

The first to give a good account of Jamaica quassia was John
Lindsay,[515] a medical practitioner of the island, who writing in 1791
described the tree as long known not only for its excellent timber, but
also as a useful medicine in putrid fevers and fluxes. He adds that
the _bark_ is exported to England in considerable quantity—“for the
purposes of the brewers of ale and porter.”

Quassia, defined as the wood, bark, and root of _Q. amara_ L., was
introduced into the London Pharmacopœia of 1788; in the edition of
1809, it was superseded by the wood of _Picræna excelsa_. In the
stock-book of a London druggist (J. Gurney Bevan, of Plough Court,
Lombard Street) we find it first noticed in 1781 (as _rasuræ_), when it
was reckoned as having cost 4_s._ 2_d._ per lb.

=Description=—The quassia wood of commerce consists of pieces of the
stem and larger branches, some feet in length, and often as thick as
a man’s thigh. It is covered with bark externally of a dusky grey or
blackish hue, white and fibrous within, which it is customary to strip
off and reject. The wood, which is of a very light yellowish tint, is
tough and strong, but splits easily. In transverse section it exhibits
numerous fine close medullary rays, which intersect the rather obscure
and irregular rings resembling those of annual growth of our indigenous
woody stems. The centre is occupied by a cylinder of pith of minute
size. In a longitudinal section, whether tangential or radial, the wood
appears transversely striated by reason of the small vertical height of
the medullary rays.

The wood often exhibits certain blackish markings due to the mycelium
of a fungus; they have sometimes the aspect of delicate patterns, and
at others appear as large dark patches.

Quassia has a strong, pure bitter taste, but is devoid of odour. It
is always supplied to the retail druggist in the form of turnings or
raspings, the former being obtained in the manufacture of the _Bitter
Cups_, now often seen in the shops.

=Microscopic Structure=—The wood consists for the most part of
elongated pointed cells (libriform), traversed by medullary rays, each
of the latter being built up of about 15 vertical layers of cells. The
single layers contain from one to three rows of cells. The ligneous
rays thus enclosed by medullary parenchyme, are intersected by groups
of tissue constituting the above-mentioned irregular rings. On a
longitudinal section this parenchyme exhibits numerous crystals of
oxalate of calcium, and sometimes deposits of yellow resin. The latter
is more abundant in the large vessels of the wood. Oxalate and resin
are the only solid matters perceptible in the tissues of this drug.

=Chemical Composition=—The bitter taste of quassia is due to
_Quassiin_, which was first obtained, no doubt, from the wood of
_Quassia amara_, by Winckler in 1835. It was analysed by Wiggers,[516]
who assigned it the formula C₁₀H₁₂O₃, now regarded as doubtful.
According to the latter, quassiin is an irresolvable, neutral
substance, crystallizable from dilute alcohol or from chloroform. It
requires for solution about 200 parts of water, but is not soluble in
ether; it forms an insoluble compound with tannic acid. Quassia wood
is said to yield about ⅒ per cent. of quassiin. A watery infusion of
quassia, especially if a little caustic lime has been added to the
drug, displays a slight fluorescence, due apparently to quassiin.
Goldschmiedt and Weidel (1877) failed in obtaining quassiin. They
isolated the yellow resin which we mentioned above, and stated that it
yields protocatechuic acid when melted with potash. Quassia wood dried
at 100° C. yielded us 7·8 per cent. of ash.

[515] _Trans. Roy. Soc. Edinburgh_, iii. (1794) 205. tab. 6.

[516] Liebig’s _Annalen der Pharm._ xxi. (1837) 40.

=Commerce=—The quantity of Bitter Wood shipped from Jamaica in 1871 was
56 tons.[517]

=Uses=—The drug is employed as a stomachic and tonic. It is poisonous
to flies, and is not without narcotic properties in respect to the
higher animals.

=Substitutes=—The wood of _Quassia amara_ L., the _Bitter Wood of
Surinam_, bears a close resemblance, both external and structural,
to the drug just noticed; but its stems never exceed four inches in
diameter and are commonly still thinner. Their thin, brittle bark is
of a greyish yellow, and separates easily from the wood. The latter
is somewhat denser than the quassia of Jamaica, from which it may be
distinguished by its medullary rays being composed of a single or less
frequently of a double row of cells, whereas in the wood of _Picræna
excelsa_, they consist of two or three rows, less frequently of only
one.

Surinam Quassia Wood is exported from the Dutch colony of Surinam. The
quantity shipped thence during the nine months ending 30th Sept, 1872,
was 264,675 lb.[518]

The bark of _Samadera indica_ Gärtn., a tree of the same natural order,
owes its bitterness to a principle[519] which agrees perhaps with
quassiin. The aqueous infusion of the bark is abundantly precipitated
by tannic acid, a compound of quassiin probably being formed. A similar
treatment applied to quassia would possibly easier afford quassiin than
the extraction of the wood by means of alcohol, as performed by Wiggers.




BURSERACEÆ.


OLIBANUM.

_Gummmi-resina Olibanum_, _Thus masculum_[520]; _Olibanum_,
_Frankincense_; F. _Encens_; G. _Weihrauch_.

[517] _Blue Book_, Island of Jamaica, for 1871.

[518] _Consular Reports_, No. 3, presented to Parliament, July 1873.

[519] Rost van Tonningen, _Jahresbericht_ of Wiggers (Canstatt) for
1858. 75; _Pharm. Journ._ ii. (1872) 644. 654.

[520] The λίβανος of the Greeks, the Latin _Olibanum_, as well as
the Arabic _Lubân_, and the analogous sounds in other languages, are
all derived from the Hebrew _Lebonah_, signifying _milk_: and modern
travellers who have seen the frankincense trees state that the fresh
juice is _milky_, and hardens when exposed to the air. The word _Thus_,
on the other hand, seems to be derived from the verb θύειν, _to
sacrifice_.

=Botanical Origin=—Olibanum is obtained from the stem of several
species of _Boswellia_, inhabiting the hot and arid regions of Eastern
Africa, near Cape Gardafui and of the southern coast of Arabia.
Notwithstanding the recent elaborate and valuable researches of
Birdwood,[521] the olibanum trees are still but imperfectly known, as
will be evident in the following enumeration:—

1. _Boswellia Carterii_ Birdw.—This includes the three following forms,
which may be varieties of a single species, or may belong to two or
more species,—a point impossible to settle until more perfect materials
shall have been obtained.

a. _Boswellia_ No. 5, Oliver, _Flora of Tropical Africa_, I. (1868)
324, _Mohr meddu_ or _Mohr madow_ of the natives; _meddu_, according
to Playfair and Hildebrandt, means black. The leaflets are crenate,
undulate, and pubescent on both sides.

This tree is found in the Somali Country, growing a little inland in
the valleys and on the lower part of the hills, never on the range
close to the sea. It yields the olibanum called _Lubân Bedowi_ or
_Lubân Sheheri_ (Playfair).

Hildebrandt describes the Mohr meddu as a tree 12 to 15 feet high, with
a few branches, indigenous to the limestone range of Ahl or Serrut, in
the northern part of the Somali Country, where it occurs in elevations
of from 3000 to 5000 feet. To this tree belongs the figure 58 in
Bentley and Trimen’s _Medicinal Plants_ (Part 20, 1877).

b. _Boswellia_ No. 6, Oliver, _op. cit._, Birdwood, _Linn. Trans._
xxvii., tab. 29.—Sent by Playfair among the specimens of the preceding,
and with the same indications and native name. This form, the “Mohr
meddu” of the Somalis, has obscurely serrulate or almost entire
leaflets, velvety and paler below, glabrous above. The figure (which
is not given in the reprint) is very much the same as that of the
following.

c. _Maghrayt d’sheehaz_ of the Maharas, Birdwood, _l. c._ tab. 30,
reprinted in Cooke’s report, plate I; Carter, _Journ. of Bombay Branch
of R. Asiat. Soc._ ii., tab. 23; _B. sacra_ Flückiger, _Lehrbuch der
Pharmakognosie des Pflanzenreiches_, 1867. 31.—Ras Fartak, S.E. coast
of Arabia, growing in the detritus of limestone cliffs and close to the
shore,[522] also near the village of Merbat (Carter, 1844-1846).

Birdwood’s figure refers to a specimen propagated in the Victoria
Gardens, Bombay, from cuttings sent there from the Somali country by
Playfair.

2. _B. Bhau-Dajiana_ Birdw. _l. c._ tab. 31, or plate III. of the
reprint.—Somali Country (Playfair); cultivated in Victoria Gardens,
Bombay, where it flowered in 1868. The differences between this species
and B. Carterii are not very obvious.

[521] _On the Genus_ Boswellia, _with descriptions and figures of
three new species.—Linn. Trans._ xxvii. (1870) 111. 148. This paper
is reprinted as an appendix to Cooke’s “Report on the gums, resins,
... of the Indian Museum,” Lond. 1874.—The original plates are much
superior and more complete than the reprints.—The materials on which
Dr. Birdwood’s observations have been chiefly founded, and to which we
also have had access, are,—1. Specimens collected during an expedition
to the Somali Coast made by Col. Playfair in 1862.—2. Growing Plants at
Bombay and Aden, raised from cuttings sent by Playfair.—3. A specimen
obtained by H. J. Carter in 1846, near Ras Fartak, on the south-east
coast of Arabia, and still growing in Victoria Gardens, Bombay; and
figured by Carter in _Journ. of Bombay Branch of R. Asiatic_ Soc. ii.
(1848) 380, tab. 23.

[522] In the λιβανωτοϕόρος χώρα of the antiquity, the hill region
(where Mohr meddu is growing) used to be contrasted with the coast
region, the Sahil. See Sprenger (quoted further on, page 136, footnote
3), page 90.

3. _Boswellia_ No. 4, Oliver, _op. cit._—Bunder Murayah, Somali Country
(Playfair). Grows out of the rock, but sometimes in the detritus of
limestone; never found on the hills close to the sea, but further
inland and on the highest ground. Yields _Lubân Bedowi_ and _L.
Sheheri_; was received at Kew as _Mohr add_, a name applied by Birdwood
also to _B. Bhau-Dajiana_.

From the informations due to Captains Miles[523] and Hunter and to
Haggenmacher[524] it would appear that the _Beyo_ or _Beyu_ of the
Somalis (Boido, Capt. Hunter) is agreeing with this tree.

4. _Boswellia neglecta_, S. Le M. Moore, in _Journ. of Botany_,
xv.(1877) 67 and tab. 185. This tree has been collected by Hildebrandt
in the limestone range, Ahl or Serrut, in the northern part of the
Somali Country. It occurs in elevations of 1000 to 1800 metres,
and attains a height of 5 to 6 metres. Its exudation, according to
Hildebrandt, is collected in but small quantity and mixed with the
other kinds of olibanum. Moore gives _Murlo_ as the vernacular name of
this tree, Hildebrandt calls it _Mohr add_.

In addition to the foregoing, from which the olibanum of commerce is
collected, it may be convenient to mention also the following:—

1. _Boswellia Frereana_ Birdw., a well-marked and very distinct species
of the Somali Country, which the natives call _Yegaar_. It abounds in
a highly fragrant resin collected and sold as _Lubân Meyeti_ or _Lubân
Mati_, which we regard to be the substance originally known as _Elemi_
(see this article).

2. _B. papyrifera_ Richard (_Plösslea floribunda_ Endl.), the “Makar”
of Sennaar and the mountainous region ascending to 4000 feet above the
level of the sea on the Abyssinian rivers Takazze and Mareb. It appears
not to grow in the outer parts of north-eastern Africa. Its resin
is not collected, and stated by Richard[525] to be transparent; it
consists no doubt merely of resin (and essential oil?) without gum.[526]

3. _B. thurifera_ Colebr. (_B. glabra_ et _B. serrata_ Roxb.), the
_Salai_ tree of India, produces a soft odoriferous resin which is used
in the country as incense but is not the olibanum of commerce. The tree
is particularly abundant on the trap hills of the Dekhan and Satpura
range. Berg, in “Offizinelle Gewächse,” xiv. c. gives a good figure of
this species.

=History=—The use of olibanum goes back to a period of extreme
antiquity, as proved by the numerous references[527] in the writings of
the Bible to _incense_, of which it was an essential ingredient. It is
moreover well known that many centuries before Christ, the drug was one
of the most important objects of the traffic which the Phœnicians[528]
and Egyptians carried on with Arabia.

[523] See his picturesque description of the tree, _Journ. R. Geograph.
Soc._ 22 (1872) 64.

[524] Flückiger, _Pharm. Journ._ viii. (1878) 805.

[525] _Tent. Floræ Abyssinicae_, i. (1847) 248; figure of the tree tab.
xxxiii.

[526] See the paper quoted in note 2.

[527] As for instance, Exod. xxx. 34; I Chron. x. 29; Matth. ii. 11.

[528] Movers, _Das phönizische Alterthum_, iii. (1856) 99.
299.—Sprenger, _l. c._ p. 299, also points out the importance of
the olibanum with regard to the commercial relations of those early
periods.

Professor Dümichen[529] of Strassburg has discovered at the temple
of Dayr el Báhri in Upper Egypt, paintings illustrating the traffic
carried on between Egypt and a distant country called Punt or Pount
as early as the 17th century B.C. In these paintings there are
representations not only of bags of olibanum, but also of olibanum
trees planted in tubs or boxes, being conveyed by ship from Arabia to
Egypt. Inscriptions on the same building, deciphered by Professor D.,
describe with the utmost admiration the shipments of precious woods,
heaps of incense, verdant incense trees,[530] ivory, gold, stimmi
(sulphide of antimony), silver, apes, besides other productions not yet
identified. The country Pount was first thought to be southern Arabia,
but is now considered to comprehend the Somali coast, together with a
portion of the opposite Arabian coast. Punt possibly refers to “Opone,”
an old name for Hafoon, a place south of Cape Gardafui.

A detailed account of frankincense is given by Theophrastus[531] (B.C.
370-285) who relates that the commodity is produced in the country
of the Sabæans, one of the most active trading nations of antiquity,
occupying the southern shores of Arabia. It appears from Diodorus that
the Sabæans sold their frankincense to the Arabs, through whose hands
it passed to the Phœnicians who disseminated the use of it in the
temples throughout their possessions, as well as among the nations with
whom they traded. The route of the caravans from south-eastern Arabia
to Gaza in Palestine, has recently (1866) been pointed out by Professor
Sprenger. Plutarch relates that when Alexander the Great captured Gaza,
500 talents of olibanum and 100 talents of myrrh were taken, and sent
thence to Macedonia.

The _libanotophorous region_ of the old Sabæans is in fact the very
country visited by Carter in 1844 and 1846, and lying as he states on
the south coast of Arabia between long. 52° 47′ and 52° 23′ east.[532]
It was also known to the ancients, at least to Strabo and Arrian, that
the opposite African coast likewise produced olibanum,[533] as it is
now doing almost exclusively; and the latter states that the drug is
shipped partly to Egypt and partly to Barbaricon at the mouth of the
Indus.

As exemplifying the great esteem in which frankincense was held
by the ancients, the memorable gifts presented by the Magi to the
infant Saviour will occur to every mind. A few other instances may be
mentioned: Herodotus[534] relates that the Arabians paid to Darius,
king of Persia, an annual tribute of 1000 talents of frankincense.

A remarkable Greek inscription, brought to light in modern times[535]
on the ruins of the temple of Apollo at Miletus, records the gifts
made to the shrine by Seleucus II., king of Syria (B.C. 246-227),
and his brother Antiochus Hierax, king of Cilicia, which included in
addition two vessels of gold and silver, ten talents of frankincense
(λιβανωτοός) and one of myrrh.

[529] Dümichen (Johannes), _The fleet of an_ _Egyptian Queen from the
17th century before our era, and ancient Egyptian military parade,
represented on a monument of the same age ... after a copy taken
from the terrace of the temple of Dêr-el-Baheri_, translated from
the German by Anna Dümichen, Leipzig, 1868.—See also Mariette-Bey,
_Deir-el-Bahari_, Leipzig, 1877, Pl. 6, 7, 8.

[530] In one of the inscriptions they are referred to in terms which
Professor D. has thus rendered:—“Thirty-one verdant incense trees
brought among the precious things from the land of Punt for the majesty
of this god Amon, the lord of the terrestrial thrones. Never has
anything similar been seen since the foundation of the world.”

[531] _Hist. Plant._ lib. iv. c. 7.—See also Sprenger, _l.c._ 219.

[532] See also Sprenger, _Die alte Geographie Arabiens_. Bern, 1875.
296, 302, also 244.

[533] “Thus transfretanum,” Sprenger, 299.

[534] Rawlinson’s _Herodotus_, ii. (1858) 488.—Sprenger, _l. c._ 300,
alludes to olibanum being exported to Babylonia and Persia.

[535] Chishull, _Antiquitates Asiaticæ_, Lond. 1758. 65-72.

The emperor Constantine made numerous offerings to the church under St.
Silvester, bishop of Rome A.D. 314-335, of costly vessels and fragrant
drugs and spices,[536] among which mention is made in several instances
of _Aromata_ and _Aromata in incensum_, terms under which olibanum is
to be understood.[537]

With regard to the consumption of olibanum in other countries, it
is an interesting fact that the Arabs in their intercourse with the
Chinese, which is known to have existed as early as the 1Oth century,
carried with them _olibanum_, myrrh, dragon’s blood, and liquid
storax,[538] drugs which are still imported from the west into China.
The first-named is called _Ju-siang_, i.e. _milk perfume_, a curious
allusion to its Arabic name _Lubân_ signifying _milk_. In the year
1872, Shanghai imported[539] of this drug no less than 1,360 peculs
(181,333 lb.).

=Collection=—The fragrant gum-resin is distributed through the leaves
and bark of the trees, and even exudes as a milky juice also from the
flowers; its fragrance is stated to be already appreciable in a certain
distance. Cruttenden,[540] who visited the Somali Country in 1843, thus
describes the collecting of olibanum by the Mijjertheyn tribe, whose
chief port is Bunder Murayah (lat. 11° 43′ N.)[541]:—

“During the hot season the men and boys are daily employed in
collecting gums, which process is carried on as follows:—About the end
of February or beginning of March, the Bedouins visit all the trees
in succession and make a deep incision in each, peeling off a narrow
strip of bark for about 5 inches below the wound. This is left for a
month when a fresh incision is made in the same place, but deeper. A
third month elapses and the operation is again repeated, after which
the gum is supposed to have attained a proper degree of consistency.
The mountain sides are immediately covered with parties of men and
boys, who scrape off the large clear globules into a basket, whilst
the inferior quality that has run down the tree is packed separately.
The gum when first taken from the tree is very soft, but hardens
quickly.... Every fortnight the mountains are visited in this manner,
the trees producing larger quantities as the season advances, until the
middle of September, when the first shower of rain puts a close to the
gathering that year.”

The informations due to J. M. Hildebrandt, who visited the Somali in
1875, are in accordance with Cruttenden’s statements. The former says,
that the latest crops are greatly injured by the rains, the drug being
partly dissolved by the water.

[536] These remarkable gifts are enumerated by Vignoli in his _Liber
Pontificalis_, Rome, 1724-55, and include beside Olibanum, _Oleum
nardinum_, _Oleum Cyprium_, _Balsam_, _Storax Isaurica_, _Stacte_,
_Aromata cassiæ_, _Saffron_ and _Pepper_.

[537] The ancient name of Cape Gardafui was _Promontorium Aromatum_.

[538] Bretschneider, _Ancient Chinese_, &c. Lond. 1871. 19.

[539] _Returns of Trade at the Treaty Ports in China for_ 1872, p. 4.

[540] _Trans. Bombay Geograph. Soc._ vii. (1846) 121.

[541] See sketch of the Somali coast. _Pharm. Journ._ viii. (13 Apr.
1878) 806.

Carter[542] describing the collection of the drug in southern Arabia,
writes thus:—“The gum is procured by making longitudinal incisions
through the bark in the months of May and December, when the cuticle
glistens with intumescence from the distended state of the parts
beneath; the operation is simple, and requires no skill on the part
of the operator. On its first appearance the gum comes forth white as
milk, and according to its degree of fluidity, finds its way to the
ground, or concretes on the branch near the place from which it first
issued, from whence it is collected by men and boys employed to look
after the trees by the different families who possess the land in which
they grow.” According to Captain Miles,[543] the drug is not collected
by the people of the country, but by Somalis who cross in numbers from
the opposite coast, paying the Arab tribes for the privilege. The
Arabian Lubân, he says, is considered inferior to the African.

It would even appear that the collection of the drug has ceased in
Arabia, and that the names of Lubân Maheri or Mascati or Sheehaz,
referring to the coast of Arabia between Ras Fartak (52° 10′ E.) and
Ras Morbas (54° 34′) are now applied to the olibanum brought there from
the opposite African coast.[544] Hildebrandt informed one of us (letter
dated 26th Dec., 1878) that he has ascertained at Aden, that all the
frankincense imported in Aden comes from Africa.

=Description=—Olibanum as found in commerce varies rather considerably
in quality and appearance. It may in general terms be described as a
dry gum-resin, consisting of detached tears up to an inch in length, of
globular, pear-shaped, clavate, or stalactitic form, mixed with more
or less irregular lumps of the same size. Some of the longer tears are
slightly agglutinated, but most are distinct. The predominant forms are
rounded,—angular fragments being less frequent, though the tears are
not seldom fissured. Small pieces of the translucent brown papery bark
are often found adhering to the flat pieces. The “Lubân Fasous Bedow”
as exported from the Mijjertheyn district, in the eastern part of the
Somali Country, is in very fine large tears.

The colour of the drug is pale yellowish or brownish, but the finer
qualities consist of tears which are nearly colourless or have a
greenish hue. The smallest grains only are transparent, the rest are
translucent and somewhat milky, and not transparent even after the
removal of the white dust with which they are always covered. But if
heated to about 94° C., they become almost transparent. When broken
they exhibit a rather dull and waxy surface. Examined under the
polarizing microscope no trace of crystallization is observable.

Olibanum softens in the mouth; its taste is terebinthinous and slightly
bitter, but by no means disagreeable. Its odour is pleasantly aromatic,
but is only fully developed when the gum-resin is exposed to an
elevated temperature. At 100° C. the latter softens without actually
fusing, and if the heat be further raised decomposition begins.

[542] See my paper on Luban Mati and Olibanum, _Pharm. Journ._ viii.
(1878) 805, also Hildebrandt’s note in the “Sitzungs-Bericht der
Gesellschaft naturforschender Freunde zu Berlin,” 19th Nov. 1878,
195.—F. A. F..

[543] _Loc. cit._

[544] _On the neighbourhood of Bunder Murayah_, in _Journ. of R.
Geograph. Society_, xxii. (1872) 65.

=Chemical Composition=—Cold water quickly changes olibanum into a soft
whitish pulp, which when rubbed down in a mortar forms an emulsion.
Immersed in spirit of wine, a tear of olibanum is not altered much
in form, but it becomes of an almost pure opaque white. In the first
case the water dissolves the gum, while in the second the alcohol
removes the resin. We find that pure olibanum treated with spirit
of wine leaves 27 to 35 of gum,[545] which forms a thick mucilage
with three parts of water. Dissolved in 5 parts of water it yields a
neutral solution, which is precipitated by perchloride of iron as well
as by silicate of sodium, but not by neutral acetate of lead. It is
consequently a gum of the same class as gum arabic, if not identical
with it. Its solution contains the same amount of lime as gum arabic
affords.

The resin of olibanum has been examined by Hlasiwetz (1867), according
to whom it is a uniform substance having the composition C₂₀H₃₀O₃.
We find that it is not soluble in alkalis, nor have we succeeded in
converting it into a crystalline body by the action of dilute alcohol.
It is not uniformly distributed throughout the tears; if they are
broken after having been acted upon by dilute alcohol, it now and
then happens that a clear stratification is perceptible, showing a
concentric arrangement.

Olibanum contains an essential oil, of which Braconnot (1808) obtained
5 per cent., Stenhouse (1840) 4 per cent., and Kurbatow (1871-1874) 7
per cent. According to Stenhouse it has a sp. gr. of 0·866, a boiling
point of 179·4° C., and an odour resembling that of turpentine but more
agreeable. Kurbatow separated this oil into two portions, the one of
which has the formula C₁₀H₁₆, boils at 158° C., and combines with HCl
to form crystals; the other contains oxygen. The bitter principle of
olibanum forms an amorphous brown mass.

The resin of olibanum submitted to destructive distillation affords no
umbelliferone. Heated with strong nitric acid it develops no peculiar
colour, but at length camphretic acid (see Camphor) is formed, which
may be also obtained from many resins and essential oils if submitted
to the same oxidizing agent.

=Commerce=—The olibanum of Arabia is shipped from several small places
along the coast between Damkote and Al Kammar, but the quantity
produced in this district is much below that furnished by the Somali
Country in Eastern Africa. The latter is brought to Zeyla, Berbera,
Bunder Murayah, and many smaller ports, whence it is shipped to Aden
or direct to Bombay. The trade is chiefly in the hands of Banians, and
the great emporium for the drug is Bombay. A certain portion is shipped
through the straits of Bab-el-Mandeb to Jidda,—Von Kremer[546] says to
the value of £12,000 annually. The quantity exported from Bombay in the
year 1872-73 was 25,100 cwt., of which 17,446 cwt. were shipped to the
United Kingdom, and 6,184 cwt. to China.[547]

=Uses=—As a medicine olibanum is nearly obsolete, at least in Britain.
The great consumption of the drug is for the incense used in the Roman
Catholic and Greek Churches.

[545] I obtained 32·14 per cent. from the finest tears of the kind
called Fasous Bedowi, with which I was presented by Capt. Hunter of
Aden.—F. A. F..

[546] _Aegypten, Forschungen über Land und Volk_, Leipzig, 1863.

[547] _Statement of the Trade and Navigation of the Presidency of
Bombay for_ 1872-73, pt. ii. 78.


MYRRHA.

_Gummi-resina Myrrha_; _Myrrh_; F. _Myrrhe_; G. _Myrrhe_.

=Botanical Origin=—Ehrenberg who visited Egypt, Nubia, Abyssinia, and
Arabia in the years 1820-26, brought home with him specimens of the
myrrh trees found at Ghizan (Gison or Dhizân), a town on the strip of
coast-region called Tihâma, opposite the islands of Farsan Kebir and
Farsan Seghir, and a little to the north of Lohaia, on the eastern
side of the Red Sea, in latitude 16° 40′, and also on the neighbouring
mountains of Djara (or Shahra) and Kara. Here the myrrh trees form
the underwood of the forests of _Acacia_, _Moringa_, and _Euphorbia_.
Nees von Esenbeck who examined these specimens, drew up from them a
description of what he called _Balsamodendron Myrrha_, which he figured
in 1828.[548]

After Ehrenberg’s herbarium had been incorporated in the Royal
Herbarium of Berlin, Berg examined these specimens, and came to
the conclusion that they consist of _two species_, namely that
described and figured by Nees, and a second to which was attached
(_correctly_ we must hope) two memoranda bearing the following
words:—“_Ipsa Myrrhæ arbor ad Gison,—Martio_,” and “_Ex huic simillima
arbore ad Gison ipse Myrrham effluentem legi_.[549] _Hæc specimina
lecta sunt in montibus Djara et Kara Februario._” This plant Berg
named _B. Ehrenbergianum_.[550] Oliver in his _Flora of Tropical
Africa_ (1868)[551] is disposed to consider Berg’s plant the same
as _B. Opobalsamun_ Kth., a tree or shrub yielding myrrh, found by
Schweinfurth on the Bisharrin mountains in Abyssinia, not far from the
coast between Suakin and Edineb. But Schweinfurth himself does not
admit the identity of the two plants.[552] It is certain, however, that
the myrrh of commerce is chiefly of African origin.

Captain F. M. Hunter, Assistant Resident of Aden, informed us[553]
that the Arabian myrrh tree, the _Didthin_, is found not only in the
southern provinces of Arabia, Yemen, and Hadramant, probably also in
the southern part of Oman, but likewise on the range of hills which,
on the African shore, runs parallel to the Somali coast. The Somalis
who gather the myrrh in Arabia allege that the Arabian “Didthin”
is identical with that of their own district. Its exudation is the
true myrrh, “_Mulmul_” of the Somalis, the “_Mur_” of the Arabs, or
“_Heerabole_”[554] of the Indians.

[548] _Plantæ Medicinales_, Düsseldorf, ii. (1828) tab. 355.

[549] On applying in 1872 to Prof. Ehrenberg to know if it were
possible that we could _see_ this very specimen, we received the answer
that it could not be found.

[550] Berg u. Schmidt, _Darstellung u. Beschreibung ... offizin.
Gewächse_, iv. (1863) tab. xxix. d.; also _Bot. Zeitung_, 16 Mai, 1862.
155.

[551] Vol. i. 326.

[552] Petermann, _Geogr. Mittheilungen_, 1868. 127.

[553] Letters addressed in 1877 to F. A. F..

[554] _Bola_, _Bal_, or _Bol_ were names of the myrrh in the Egyptian
antiquity.—Ehrenberg, _De Myrrhæ et Opocalpasi ... detectis plantis_,
Berolini, 1841, fol.

Another myrrh tree, according to Captain Hunter, is growing in Ogadain
and the districts round Harrar, that is between the 7th and 10th
parallels, N. lat., and 43° to 50° E. long. This is the “_Habaghadi_”
of the Somalis, which is not found in Arabia, nor in the coast range
of the Somali country, but only at a considerable distance from the
sea-shore. Its exudation is the coarse myrrh, habaghadi of the Somalis
and Arabs and “_Baisabole_” of the Indians.

Hildebrandt has collected the didthin, or didin as he writes, in the
coast range alluded to, that is in the Ahl or Serrut Mountains, where
the tree is growing on sunny slopes in elevations of 500 to 1,500
metres. He has ascertained that it is identical with Ehrenberg’s tree,
_Balsamodendron Myrrha_ Nees. It is a low tree of crippled appearance,
attaining not more than 3 metres. This species must therefore be
pointed out as the source of true myrrh of the European commerce.

=History=—(See also further on, Bissabol). Myrrh has been used from the
earliest times together with olibanum as a constituent of incense,[555]
perfumes, and unguents. It was an ingredient of the holy oil used in
the Jewish ceremonial as laid down by Moses: and it was also one of
the numerous components of the celebrated _Kyphi_ of the Egyptians,
a preparation used in fumigations, medicine, and the process of
embalming, and of which there were several varieties.

In the previous article we have pointed out (p. 137) several early
references to myrrh in connection with olibanum, in which it is
observable that the myrrh (when weights are mentioned) is always in
the smaller quantity. Of the use of the drug in mediæval Europe there
are few notices, but they tend to show that the commodity was rare and
precious. This myrrh is recommended in the Anglo-Saxon Leech-books[556]
to be used with frankincense in the superstitious medical practice
of the 11th century. In a manuscript of the Monastery of Rheinau,
near Schaffhausen, Switzerland, we also find that, apparently in the
11th century, myrrh as well as olibanum were used in ordeals in the
“judicium aquæ bullientis.”[557] The drug was also used by the Welsh
“Physicians of Myddfai” in the 13th century. In the Wardrobe accounts
of Edward I. there is an entry under date 6th January, 1299, for
gold, frankincense, and _myrrh_, offered by the king in his chapel on
that day, it being the Feast of Epiphany.[558] Myrrh again figures
in the accounts of Geoffroi de Fleuri,[559] master of the wardrobe
(_argentier_) to Philippe le Long, king of France, where record is
made of the purchase of—“4 onces d’estorat calmite” (see Styrax) “et
_mierre_ (myrrh) ... encenz et laudanon,” (Ladanum, the resin of Cistus
creticus L.)—for the funeral of John, posthumous son of Louis X., A.D.
1316.

Gold, silver, silk, precious stones, pearls, camphor, musk, _myrrh_,
and spices are enumerated[560] as the presents which the Khan of Cathay
sent to Pope Benedict XII. at Avignon about the year 1342. The myrrh
destined for this circuitous route to Europe[561] was doubtless that
of the Arabian traders, with whom the Chinese had constant intercourse
during the middle ages. Myrrh in fact is still somewhat largely
consumed in China.[562]

[555] Cantic. i 13, iii. 6; Genes. xliii. 11; Exod. ii. 12, 30, xxiii.
34-36; John xix. 39; Mark xv. 23; Proverbs vii. 17.

[556] Cockayne, _Leechdoms &c. of Early England_, ii. (1865) 295, 297.

[557] Range, _Adjurationen, Exorcismen, Benedictionen, &c., in
Mittheilungen der antiquar. Gesellschaft in Zürich_, xii. (1859) 187.

[558] _Liber quotidianus Contrarotulatoris Garderobæ.... Edwardi I._,
Lond. 1787. pp. xxxii. and 27.—The custom is still observed by the
sovereigns of England, and the Queen’s oblation of gold, frankincense,
and myrrh is still annually presented on the Feast of Epiphany in the
Chapel Royal in London.

[559] Doüet d’Arcq, _Comptes de l’Argenterie des rois de France_, 1851.
19.

[560] Yule, _Cathay and the way thither_, ii. 357.

[561] For the costly presents in question _never reached their
destination_, having been all plundered by the way!

[562] Shanghai imported in 1872, 18,600 lbs. of myrrh.—_Reports of
Trade at the Treaty Ports in China for_ 1872, p. 4.

The name _Myrrh_ is from the Hebrew and Arabic _Mur_, meaning bitter,
whence also the Greek σμύρνα. The ancient Egyptian _Bola_ or _Bal_,
and the Sanskrit _Vola_ are preserved in the Persian and Indian words
_Bol_, _Bola_, and _Heerabol_, well-known names for myrrh.

_Stacte_ (στακτὴ), a substance often mentioned by the ancients, is said
by Pliny to be a spontaneous liquid exudation of the myrrh tree, more
valuable than myrrh itself. The author of the Periplus of the Erythrean
Sea represents it as exported from Muza in Arabia[563] together with
myrrh. Theophrastus[564] speaks of myrrh as of two kinds, solid and
liquid. No drug of modern times has been identified with the _stacte_
or _liquid myrrh_ of the ancients: that it was a substance obtainable
in quantity seems evident from the fact that 150 pounds of it, said to
be the offering of an Egyptian city, were presented to St. Silvester at
Rome, A.D. 314-335.[565]

The myrrh of the ancients was not always obtained from Arabia. The
author of the Periplus,[566] who wrote about A.D. 64, records it to
have been an export of Abalites, Malao, and Mosyllon (the last named
the modern Berbera), ancient ports of the African coast outside the
straits of Bab-el-Mandeb; and he even mentions that it is conveyed by
small vessels to the opposite shores of Arabia.

=Secretion=—Marchand[567] who examined and figured the sections of a
branch of three years’ growth of _B. Myrrha_, represents the gum-resin
as chiefly deposited in the cortical layers, with a little in the
medulla.

=Collection=—By the Somal tribe myrrh is largely collected as it flows
out, incisions, according to Hildebrandt, being never practised.
From the information given by Ehrenberg to Nees von Esenbeck,[568]
it appears that myrrh when it first exudes is of an oily and then of
a buttery appearance, yellowish white, gradually assuming a golden
tint and becoming reddish as it hardens. It exudes from the bark
like cherry-tree gum, and becomes dark and of inferior value by age.
Although Ehrenberg says that the myrrh he saw was of fine quality, he
does not mention it being gathered by the natives.

With regard to the localities[569] in which the drug is collected,
Cruttenden,[570] who visited the Somali coast in 1843, says that myrrh
is brought from the Wadi Nogâl, south west of Cape Gardafui, and from
Murreyhan, Ogadain and Agahora; and that some few trees are found on
the mountains behind Bunder Murayah. Major Harris[571] saw the myrrh
tree in the Adel desert and in the jungle of the Háwash, on the way
from Tajura to Shoa.

[563] Vincent, _Commerce of the Ancients_, ii. (1870) 316.—Muza or
Moosa is supposed to be identical with a place still bearing that name
lying about 20 miles east of Mokha.

[564] Lib. ix. c. 4.

[565] Vignolius, _Liber Pontificalis_, i. (1724) 95.

[566] Vincent, _op. cit._ ii. 127. 129. 135.

[567] _Recherches sur l’Organisation des Burseracées_, Paris, 1868, p.
42, pl. i.

[568] _Op. cit._ at p. 140, note 1.

[569] See paper with map in _Ocean Highways_, April, 1873, also _Pharm.
Journ._ 19 April, 1873. 821, and Hanbury’s _Science Papers_, 378.

[570] _Trans. Bombay Geogr. Soc._ vii. (1846) 123.

[571] _Highlands of Æthiopia_ (1844) i. 426; ii. 414.

Vaughan[572] states that the Somali Country and the neighbourhood of
Hurrur (or Harar or Adari, 9° 20′ N., 42° 17′ E.) south west of Zeila
are the chief producing districts. It is generally brought to the great
fair of Berbera held in November, December, and January, where it is
purchased by the Banians of India, and shipped for Bombay.

It appears that all these informations rather refer to the Bisabol or
Habaghadi variety of myrrh; only the first notice, due to Hildebrandt,
applies to true myrrh.

Myrrh trees abound on the hills about Shugra and Sureea in the
territory of the Fadhli or Fudthli tribe, lying to the eastward of
Aden; myrrh is collected from them by Somalis who cross from the
opposite coast for the purpose and pay a tribute for the privilege to
the Arabs, who appear to be scarcely acquainted with this drug.[573]
But a sample of it, received by one of us from Vaughan in 1852, and
others we have since seen in London (and easily, recognized), proved
it to be somewhat different from typical myrrh, and it is probably
afforded by another species than Balsamodendron Myrrha.

It would thus appear that there are three different trees affording
myrrh, namely that just alluded to, secondly the “Habaghadi,” and
thirdly that growing east of Aden.

=Description=—Myrrh consists of irregular roundish masses, varying
in size from small grains up to pieces as large as an egg, and
occasionally much larger. They are of an opaque reddish-brown with
dusty dull surface. When broken, they exhibit a rough or waxy fracture,
having a moist and unctuous appearance, especially when pressed, and
a rich brown hue. The fractured, translucent surface often displays
characteristic whitish marks which the ancients compared to the
light mark at the base of the finger-nails. Myrrh has a peculiar and
agreeable fragrance with an aromatic, bitter, and acrid taste. It
cannot be finely powdered until deprived by drying of some of its
essential oil and water; nor when heated does it melt like colophony.

Water disintegrates myrrh, forming a light brown emulsion, which viewed
under the microscope appears made up of colourless drops, among which
are granules of yellow resin. Alcohol dissolves the resin of myrrh,
leaving angular non-crystalline particles of gum[574] and fragments of
bark.

=Chemical Composition=—Myrrh is a mixture, in very varying proportions,
of resin, mucilaginous matters, and essential oil. A fine specimen of
myrrh from the Somali coast, with which Captain Hunter, in 1877, kindly
presented one of us, yielded 27 per cent. of resin. The undissolved
portion is partly soluble in water.

[572] _Pharm. Journ._ xii. (1853) 226.

[573] Capt. S. B. Miles, in _Journ. of R. Geograph._ Soc. xli. (1871)
236. The country visited by Miles and Munzinger is the “Smyrnifera
regio exterior,” the outer country producing myrrh of the ancients,
about 14° 10′ N. lat. and 57° E. long. See also Sprenger, _Alte
Geographie Arabiens_, 313.

[574] Druggists who prepare large quantities of Tincture of Myrrh may
utilize this gum for making a common sort of mucilage.—_Pharm. Journ._
10 June, 1871, 1001.

The resin dissolves completely in chloroform or alcohol, and the
colour of the latter solution is but slightly darkened by perchloride
of iron. It is but partially soluble in alkalis or in bisulphide of
carbon. Brückner (1867) found this portion to yield 75·6 per cent. of
carbon and 9·5 of hydrogen. The resin which the bisulphide refuses to
dissolve, is freely soluble in ether. It contains only 57·4 per cent.
of carbon. The resin of myrrh to which, when moistened with alcohol, a
small quantity of concentrated nitric or hydrochloric acid is added,
assumes a violet hue, but far less brilliant than that displayed
by resin of galbanum when treated in a similar manner. But a most
intensely violet liquid may be obtained by adding bromine to the resin
dissolved in bisulphide of carbon. If the resin of myrrh as afforded
by alcohol is warmed with petroleum (boiling at 70° C.), only a small
amount of resin is dissolved. This liquid becomes turbid if vapours of
bromine are added; a violet flocculent matter deposits, whereas the
just above-mentioned solution in the bisulphide continues clear on
addition of bromine.

The resin of myrrh is not capable of affording umbelliferone like that
of galbanum. By melting it with potash, pyrocatechin and protocatechuic
acid are produced in small amount.

Myrrh yields on distillation a volatile oil which in operating on 25
lb. of the drug, we obtained to the extent of ¾ per cent.[575] It is a
yellowish, rather viscid liquid, neutral to litmus, having a powerful
odour of myrrh and sp. gr. 0·988 at 13° C.[576] In a column 50 mm.
long, it deviates a ray of light 30·1° to the left. By submitting it
to distillation, we obtained before the oil boiled, a few drops of
a strongly acid liquid having the smell of formic acid. Neutralized
with ammonia, this liquid produced in solution of mercurous nitrate a
whitish precipitate which speedily darkened, thus indicating formic
acid, which is developed in the oil. Old myrrh is in fact said to
yield an acid distillate. The oil begins to boil at about 266° C., and
chiefly distills over between 270° and 290°.

On combustion in the usual way it afforded carbon 84·70, hydrogen 9·98.
Having been again rectified in a current of dry carbonic acid, it had
a boiling point of 262-263° C., and now afforded[577] carbon 84·70,
hydrogen 10·26, which would nearly answer to the formula C₂₂H₃₂O. The
results of Ruickholdt’s analysis (1845) of essential oil of myrrh
assign it the formula C₁₀H₁₄O, which is widely different from that
indicated by our experiments.

The oil which we rectified displays a faintly greenish hue; it is
miscible in every proportion with bisulphide of carbon, the solution
exhibiting at first no peculiar coloration when a drop of nitric or
sulphuric acid is added. Yet the mixture to which nitric acid (1·20)
has been added, assumes after an hour or two a fine violet hue which
is very persistent, enduring even if the liquid is allowed to dry up
in a large capsule. If to the crude oil dissolved in bisulphide of
carbon bromine be added, a violet hue is produced; and if the solution
is allowed to evaporate, and the residue diluted with spirit of wine,
it assumes a fine blue which disappears on addition of an alkali. The
oil is not much altered by boiling with alcoholic potash, nor does it
combine with alkaline bisulphites.

[575] Ruickholdt got 2·18 per cent.; Bley and Diesel (1845) from 1·6 to
3·4 per cent. of an acid oil. We are kindly informed by Mr. Fritzsche
of Leipzig (Messrs. Schimmel & Co.) that good myrrh distilled on a
large scale yields as much as 4·4 per cent. of oil. (Letter dated 13th
June, 1878.)

[576] Gladstone (1863) found the oil a little _heavier_ than water.

[577] Analyses performed in my laboratory by Dr. Buri, February,
1874. See also my paper on Carvol, _Pharm. Journ._ vii. (1876) 75, or
_Yearbook of Pharmacy_ (1877) 51—F. A. F.

The _Bitter principle_ of myrrh is contained in the resin as extracted
by alcohol. By exhausting the resin with warm water an acid brown
solution is obtained, from which a dark, viscid, neutral mass separates
if the liquid is concentrated; it is contaminated with a large amount
of inorganic matter, from which it may be purified by means of ether.
Yet the latter affords also but an amorphous, somewhat brittle brown
substance, softening at 80°-90° C. This bitter principle reminds us
of that mentioned in our article Elemi, page 151; it is but sparingly
soluble in water; the yellowish solution is intensely bitter. The
bitter principle of myrrh appears to be a glucoside. We have not
succeeded in preparing it in a more satisfactory state.

=Commerce=—Myrrh is chiefly shipped by way of Berbera to Aden, and
thence either to Europe or to Bombay. The exports of Aden in the fiscal
year 1875 to 1876 were 1439 cwt.; one-half of which went to Bombay, one
third to the United Kingdom.[578]

The bags or bales which contain the myrrh are opened in Bombay, and the
drug is sorted. The better portion goes to Europe, the refuse to China,
where it is probably used as an incense.[579]

=Uses=—Myrrh, though much used, does not appear to possess any very
important medicinal powers, and is chiefly employed on account of its
bitter, aromatic properties.

=Other Varieties of Myrrh=—Though the myrrh of commerce exhibits some
diversity of appearance, the drug-brokers and druggists of London are
not in the habit of applying any special designations to the different
qualities. There are however two varieties which deserve notice.

1. _Bissa Bol_ (_Bhesabol_, _Bysabole_), _Habaghadi_ or _Hebbakhade_ of
the Somalis, formerly called _East India Myrrh_.[580]

This drug is of African origin, but of the plant which yields it
nothing is known. Vaughan[581] who sent a sample from Aden to one of
us in 1852, was told by the natives that the tree from which it is
collected resembles that affording _Heera Ból_ or true myrrh, but that
it is nevertheless distinct. The drug is exported from the whole Somali
coast to Mokha, Jidda, Aden, Makulla, the Persian Gulf, India and even
China.[582] Bombay official returns show that the quantity imported
thither in the year 1872-73, was 224 cwt, all shipped from Aden.

Some myrrh, no doubt that from the interior of north-eastern Africa,
the Habaghadi or Baisabole, finds its way by the country of the
Wagadain (Ugahden or Ogadain) to the small port of Brava (Barawa,
Braoua), about 1° N. lat., and to Zanzibar.[583] This is, possibly,
also the “_Mirra fina_” which is stated, about the year 1502, by Tomé
Lopez to be collected (?) in the island of “Monzambiche.”[584]

[578] Information obligingly supplied by Captain Hunter, July 1877.

[579] Dymock, _Pharm. Journ._ vi. (1876) 661.

[580] _Myrrha indica_, Martiny, _Encyklop. der med-pharm._
_Rohwaarenkunde_, ii. (1854) 98, 101.

[581] _Pharm. Journ._ xii. (1853) 227.

[582] In 1865, 10 packages of this drug containing about 15 cwt. were
consigned to me for sale in London by a friend in China, who had
purchased the drug under the notion that it was _true myrrh_. The
commodity was bad of its kind, and was sold with difficulty at 30_s._
per cwt.—D. H.

[583] Guillain, _Documents sur l’histoire, la géogr. et le commerce de
l’Afrique orientale_ iii. (1856) 350.

[584] In Ramusio (see Appendix, R) 239.

According to Vaughan, Bissa Bôl is mixed with the food given to milch
cows and buffaloes in order to increase the quantity and improve the
quality of their milk, and that it is also used as size to impart a
bright gloss to whitewashed walls.

Miles mentions[585] that myrrh, called there _hodthai_, is only used
in the Somali country, by men to whiten their shields (by means of an
emulsion made with the drug), by women to cleanse their hair. Probably
hodthai and habaghadi is one and the same thing.

Bissa Bôl differs from myrrh in its stronger, almost acrid _taste_
and in _odour_, which, when once familiar is easily recognizable;
fine specimens of the former have the outward characters of myrrh
and perhaps are often passed off for it. A good sample of “coarse”
habaghadi myrrh as sent in 1877 by Captain Hunter from Aden proved
to contain but very little resin. This resin is manifestly different
from that of myrrh as already shown by its paler, more reddish colour.
The resin of Bissa Bôl moreover is but very sparingly soluble in
bisulphide of carbon; this solution is _not altered_ by bromine, that
of true myrrh, as above stated, assuming a most intense violet colour
on addition of bromine. Nor is the resin of habaghadi soluble in
petroleum ether. Of the gummy substance, which is by far the prevailing
constituent of this drug, a small portion only is soluble in water.
These extremely marked differences no doubt depend upon a widely
discrepant composition of the resins of the two kinds of myrrh as well
as upon a different proportion of gum and resin. The Bissa Bôl usually
seen is an impure and foul substance, which is regarded by London
druggists as well as by the Banian traders in India as a very inferior
dark sort of myrrh.

2. _Arabian Myrrh_—The drug we have mentioned at p. 143 as collected to
the eastward of Aden, is of interest as substantiating the statement of
Theophrastus that both olibanum and myrrh grow in Southern Arabia.

The drug, which is not distinguished by any special name in English
trade, is in irregular masses seldom exceeding 1½ inches long, and
having a somewhat gummy-looking exterior. The larger lumps seem formed
by the cohesion of small, rounded, translucent, externally shining
tears or drops. The fracture is like that of common myrrh, but less
unctuous and wants the whitish markings. The odour and taste are those
of the ordinary drug. Pieces of a semi-transparent papery bark are
attached to some of the lumps. We extracted the resin of a sample of
this myrrh from the territory of the Fadhli, as sent to us by Captain
Hunter. Its solution in bisulphide of carbon or petroleum ether was
coloured by bromine as stated above, (p. 144) with regard to typical
myrrh (Heerabol) from the Somali Country. The name applies to myrrh
from the vicinity of Ras Morbat in the same region. But the resin of
another kind of Arabian myrrh, for which we are likewise indebted to
Captain Hunter, is _not coloured_ when treated in the same way. This is
the myrrh “Hodaidia Jebeli” from north and north-western Yenen.

[585] _Journ. of the R. Geogr. Soc._ 22 (1872) 64.


ELEMI.

_Resina Elemi_; _Elemi_; F. _Résine Elemi_; G. _Elemiharz_.

=Botanical Origin=—The resin known in pharmacy as _Elemi_ is derived
from a tree growing in the Philippines, which Blanco,[586] a botanist
of Manila, described in 1845 under the name of _Icica Abilo_, but which
is completely unknown to the botanists of Europe. Blanco’s description
is such that, if correct, the plant cannot be placed in either of the
old genera _Icica_ or _Elaphrium_, comprehended by Bentham and Hooker
in that of _Bursera_, nor yet in the allied genus _Canarium_; in fact
even the order to which it belongs is somewhat doubtful.[587]

The tree grows in the province of Batangas in the island of Luzon
(south of Manila), where its name in the Tagala language is _ábilo_;
the Spaniards call it _Arbol a brea_, i.e. _pitch-tree_, from the
circumstance that its resin is used for the caulking of boats.

=History=—The explicit statements of Theophrastus in the 3rd century
B.C. relative to olibanum have already been mentioned. The same writer
narrates[588] that a little above Coptus on the Red Sea, no tree is
found except the acacia (ἀκάνθη) of the desert ... but that on the sea
there grow laurel (δάϕνη) and olive (ἐλαία), from the latter of which
exudes a substance much valued to make a medicine for the staunching of
blood.

This story appears again in Pliny[589] who says that in Arabia the
olive tree exudes tears which are an ingredient of the medicine called
by the Greeks _Enhæmon_, from its efficacy in healing wounds.

Dioscorides[590] briefly notices the _Gum of the Ethiopian olive_,
which he likens to scammony; and the same substance is named by
Scribonius Largus[591] who practised medicine at Rome during the 1st
century.

The writers who have commented on Dioscorides have generally adopted
the opinion that the exudation of the so-called olive tree of Arabia
and Ethiopia was none other than the substance known to them as
_Elemi_, though, as remarked by Mattioli,[592] the oriental drug thus
called by no means well accords with the description left by that
author.

[586] _Flora de Filipians_, segunda impression, Manila, 1845. 256.

[587] On consulting Mr. A. W. Bennett, who is now studying the
_Burseraceæ_ of India, as to the probable affinities of Blanco’s plant,
we received from him the following remarks: “I have little hesitation
in pronouncing that from the description, _Icica Abilo_ cannot be
a _Canarium_, but what it is, is more difficult to say. The leaves
having the lowest pair of leaflets smallest, seems at first sight
very characteristic of _Canarium_; but the following considerations
tend the other way. 1. The _opposite_ leaves which occur nowhere in
_Burseraceæ_ except in _Amyris_, with which the plant does not agree
in many ways. 2. The _stipellæ_ which are not found anywhere in the
order.—3. The _quinate_ flowers. In all species of _Canarium_ the parts
of the flowers are in threes, including _C. commune_, which according
to Miquel extends to the Philippines. The only exception is _C._
(_Scutinanthe_ Thwaites) _brunneum_, with which it does not agree in,
other respects.

“The foregoing reasons almost equally exclude _Icica_ (_Bursera_); yet
the fruit of Blanco’s plant seems so eminently that of a _Burseracea_,
that I think it must belong to that order, but with some error in the
description of the leaves.”

[588] _Hist. Plant_, lib. iv. c. 7.

[589] Lib. xii c. 38.

[590] Lib. i. c. 141.

[591] _Compositiones Medicament_. cap. 103.

[592] _Comm. in lib. i, Dioscoridis._

As to that name, the earliest mention of it appears in the middle of
the 15th century. Thus in a list of drugs sold at Frankfort about 1450,
we find _Gommi Elempnij_.[593] Saladinus,[594] who lived about this
period, enumerates _Gumi Elemi_ among the drugs kept by the Italian
apothecaries, but we have not met with the name in any other writer
of the school of Salerno. The _Arbolayre_,[595] a herbal supposed to
have been printed about 1485, gives some account of _Gomme Elempni_,
stating that it is the gum of the lemon tree and not of fennel as some
think,—that it resembles Male Incense,—and makes an excellent ointment
for wounds.

The name _Enhæmon_[596] of Pliny, also written _Enhæmi_, is probably
the original form of the word _Animi_, another designation for the same
drug, though also applied as at the present day to a sort of copal. It
is even possible that the word _Elemi_ has the same origin.[597]

This primitive Elemi is in our opinion identical with a peculiar
sort of olibanum known as _Luban Meyeti_, afforded by _Boswellia
Frereana_ Birdwood (p. 135). It has a remarkable resemblance both
in external appearance and in odour to the substance in after-times
imported from America, and which were likened to the elemi and animi
of the Old World. The description of “gummi elemnia” given by Valerius
Cordus,[598] the most careful observer of his period, could in our
opinion well apply to _Luban Meyeti_. (See p. 153 further on.)

The first reference to Elemi as a production of America comes from
the pen of Monardes[599] who has a chapter on _Animi and Copal_.
He describes animi as of a more oily nature than copal, of a very
agreeable odour, and in grains resembling olibanum but of larger size,
and adds that it differs from the animi of the Old World in being less
white and clear.

At a somewhat later period this resin and some similar substances began
to be substituted for _Elemi_ which had become scarce.[600] Pomet,[601]
who as a dealer in drugs was a man of practical knowledge, laments that
this American drug was being sold by some as Elemi, and by others as
Animi or as Tacamaca. It was however introduced in great plenty, and
at length took the place of the original elemi which became completely
forgotten.

American Elemi was in turn discarded in favour of another sort imported
from the Philippines. The first mention of this substance is to be
found among the descriptions accompanied by drawings sent by Father
Camellus to Petiver of London, of the shrubs and trees of Luzon,[602]
in the year 1701. Camellus states that the tree, which from his drawing
preserved in the British Museum appears to us to be a species of
_Canarium_, is very tall and large, that it is called by the Spaniards
_Arbol de la brea_, and that it yields an abundance of odorous resin
which is commonly used for pitching boats. Living specimens of the tree
together with samples of the resin were brought to Paris from Manila by
the traveller Perrottet about the year 1820. For the last twenty years
the resin has been common, and is now imported in large quantities[603]
for use in the arts, so displacing all other kinds. It has been adopted
as the _Elemi_ of the _British Pharmacopœia_ (1867), and is in fact the
only variety of elemi now found in English commerce.

[593] Flückiger, _Die Frankfurter Liste_, Halle, 1873. 7. 16.—“Gumi
elemi” is also found in a similar list of the year 1480, compiled in
the town of Nördlingen, Bavaria. See _Archiv der Pharm._ 211 (1877) 103.

[594] _Compendium Aromatariorum_, Bonon. 1488.

[595] This very rare volume is one of the treasures of the National
Library of Paris.

[596] From the Greek ἔνιμον, signifying _blood-stopping_.

[597] Brassavola observes—“quandoque inclinavimus ut gummi oleæ
Æthiopicæ esset gummi _elemi_ dicti, quasi _enhæmi_.”—_Examen
simplicium_, Lugd. 1537. 386.

[598] _Hist. Stirp. libri iv._, edition of Gesner, Argentorati, 1561.
209.

[599] _Libro de las cosas que se traen de nuestras Indias
Occidentales_, Sevilla, 1565.

[600] Thus Piso in 1658 describes the resin of an _Icica_ as exactly
resembling _Elemi_ and quite as good for wounds.—_Hist. nat. et med.
Ind. Occ._ 122.

[601] _Histoire des Drogues_, 1694, 261.

[602] Ray, _Hist. Plant._ iii (1704), appendix, p. 67. No. 13.—Compare
also p. 60, No. 10.

[603] Thus in a drug sale, May 8, 1873, there were offered 275 cases,
equal to about 480 cwt.

=Description=—Manila elemi is a soft, resinous substance, of granular
consistence not unlike old honey, and when recent and quite pure is
colourless; more often it is found contaminated with carbonaceous
matter which renders it grey or blackish, and it is besides mixed
with chips and similar impurities. By exposure to the air it becomes
harder and acquires a yellow tint. It has a strong and pleasant odour
suggestive of fennel and lemon, yet withal somewhat terebinthinous.
When moistened with spirit of wine, it disintegrates, and examined
under the microscope is seen to consist partly of acicular crystals. At
the heat of boiling water the hardened drug softens, and at a somewhat
higher temperature fuses into a clear resin.

=Chemical Composition=—Manila elemi is rich in essential oil. On
submitting 28 lb. of it to distillation with water, we obtained 2 lb.
13 oz. (equivalent to 10 per cent.) of a fragrant, colourless, neutral
oil, of sp. gr. 0·861 at 15° C. Observed in Wild’s polaristrobometer we
found it to be strongly dextrogyre.[604] H. Sainte Claire Deville[605]
on the other hand has examined an oil of elemi that was strongly
levogyre. This discrepancy shows that there are among the oils of
various kinds of elemi, differences similar to those existing in the
oils of turpentine and copaiba. By the action of dry hydrochloric
acid gas, Deville obtained from his oil of elemi a solid crystalline
substance, C₁₀H₁₆ + 2 HCl. We failed to produce any such compound from
the oil of Manila elemi. Our oil of elemi dissolves in bisulphide of
carbon; when mixed with concentrated sulphuric acid, it becomes thick
and assumes a deep orange colour.

By submitting the crude oil to fractional distillation, we separated it
into six portions, of which the first five were dextrogyre in gradually
diminishing degree, while the sixth displayed a weak deviation to the
left.[606] The first portion having been dissolved in four times its
weight of strong sulphuric acid, washed and again distilled, exhibit a
deviation to the left.[607]

[604] I observed the following deviations:—

    In a column of 25 mm from 47°·5 to 70°·5 (deviation 23°).
       ”   ”       50  ”     ”         93°·6 (    ”     46·1).
       ”   ”      100  ”     ”         49°·6 (2·1 + 90 = 92°·1).
     —F. A. F.


[605] _Comptes Rendus_, xii (1841) 184.

[606] The following deviations were observed, in a column of 25
millimetres:—

         Oil
      distilled
         at
    1. 172°-180° C. from 47°·6 to 74°·5; deviation 26°·9 _right_.
    2. 180°-183°          ”       71°·2      ”    23°·6     ”
    3. 183°-184°·5        ”       68°·8      ”    21°·2     ”
    4. 184°-195°          ”       65°·8      ”    18°·2     ”
    5. 200°-230°          ”       61°·0      ”    13°·4     ”
    6. Thickish yellow    ”       46°·2      ”     1°·4  _left_.
       residue

[607] From 47°·6 to 46°.

If the essential oil of elemi (8 parts) is shaken with alcohol,
0·816 sp. gr. (2 parts), nitric acid, 1·2 sp. gr. (1 part) and
water (5 parts), the mixture, on exposure to air in a shallow
capsule soon yields large crystals, which were found to agree
crystallographically[608] perfectly with terpin, C₁₀H₂₀O₂ + OH₂ from
oil of turpentine.

Maujean,[609] a French pharmacien, examined Manila elemi as long
ago as 1821 and proved it to contain two resins, the one soluble in
cold, the other only in hot spirit of wine. The former, which appears
to constitute by far the prevailing part of all varieties of elemi,
has not yet been satisfactorily examined. Bonastre[610] a little
latter made a more complete analysis, showing that the less soluble
resin which he obtained to the extent of 25 per cent. is easily
crystallizable, and apparently identical with a substance obtainable
in a similar manner from what he regarded as true elemi, which the
Manila resin was not then held to be. Baup (1851) gave it the name of
_Amyrin_. According to our experiments, it is readily isolated to the
extent of 20 per cent. when Manila elemi is treated with cold spirit of
wine, in which the crystals of amyrin are but slightly soluble. If the
elemi is pure, the amyrin may be thus obtained (by washing with spirit
and pressure between bibulous paper) in a cake of snowy whiteness,
which may be further purified by crystallization from boiling alcohol.
The fusing point of the crystals is 177° C.; their composition has been
ascertained by Buri[611] to agree with the formula C₂₅H₄₂O, which may
be written thus: (C₅H₈)₅ OH₂. Amyrin at 16° C. dissolves in 27·5 parts
of alcohol 0·816 sp. gr., being readily soluble also in all the usual
solvents for resins. The alcoholic solution is slightly dextrogyre.
Amyrin is a neutral substance, and may be sublimed in small quantities
by very carefully heating it.

By heating amyrin with zinc dust Ciamician[612] obtained chiefly
toluol, methyl-ethyl-benzol and ethyl-naphtalin.

By allowing an alcoholic solution of the amorphous resin of Manila
elemi[613] to evaporate, Baup obtained in very small quantity crystals
of _Bréine_, a substance fusing at 187° C., which he considered to
be distinct from amyrin. In our opinion it was impure amyrin; it is
extremely difficult, or rather practically impossible to extract all
the crystallizable resin from the amorphous. If the latter, perfectly
transparent, is kept for several years, an elegant crystallization at
last begins to make its appearance throughout the bulk of the resin.

Baup further extracted from Manila elemi a crystallizable substance
soluble in water to which he gave the name of _Bryoidin_,[614] and
in smaller quantity a second also soluble in water which he called
_Bréidine_. From the experiments of Baup it appears that bryoidin is
soluble in 360 parts of water at 10° C., and melts at 135° C.; whereas
bréidine requires for solution 260 parts of water and fuses at a
temperature not much over 100° C.

[608] Examined at my request by Prof. Groth.—F. A. F..

[609] _Journ. de Pharm._ ix. (1823) 45. 47.

[610] _Id._ x. (1824) 199.

[611] _Pharm. Journ._ vii. (1876) 157, also _Yearbook of Ph._ 1877. 21.

[612] _Berichte der deutschen chemischen Gesellschaft_, 1878. 1347.

[613] I am indebted for a specimen of the material that Baup worked
upon and which he called _Resin of Arbol a brea_, to M. Roux,
pharmacien of Nyon, Switzerland—F. A. F.

[614] From the Greek βρύον, in allusion to the moss-like aspect
sometimes assumed by the crystals.

We have also obtained _Bryoidin_[615] by operating in the following
manner: the watery liquid left in the still after the distillation of
28 lb. of Manila elemi was poured off from the mass of hard resin,
and having been duly concentrated, it deposited together with a
dark extractiform matter, colourless acicular crystals of bryoidin.
The deposit in question having been drained and allowed to dry, the
bryoidin may be separated by boiling water or by cold ether. We found
the latter the more convenient; it readily takes up the bryoidin
contaminated only with a little resin. The ethereal solution should
be allowed to evaporate and the residual crystalline mass boiled in
water, when the solution (which is colourless), poured off from the
resin, will deposit upon cooling brilliant tufts of acicular crystals
of bryoidin. The boiling in water requires to be several times
repeated before the whole of the bryoidin can be removed; the latter
sometimes crystallizes as a mossy arborescent growth. Bryoidin is a
neutral substance, of bitter taste, scarcely soluble in cold water,
but dissolving easily in boiling water, or in alcohol or ether. When
a little is placed in a watch-glass, covered with a plate of glass,
and then gently heated over a lamp, it sublimes in delicate needles.
To obtain it perfectly pure, it is best to sublime it in a current
of dry carbonic acid. Thus purified its fusing point is 133·5 C.;
after fusion it concretes as a transparent, amorphous mass, which if
immersed in glycerin and raised to the temperature of 135° C., suddenly
crystallizes.

We have observed that if the filtered mother-liquor of bryoidin after
complete cooling and standing for a day or two is warmed, it becomes
turbid and that in a few minutes there separate from it long white
flocks like bits of paper or wool, which do not disappear either by
warming or by cooling the liquid; under the microscope they are seen
to consist partly of thread-like, partly of acicular crystals. It is
possible this substance is Baup’s _Bréidine_; we found it to fuse at
135° C., to be neutral, and to crystallize from weak alcohol exactly
like bryoidin. Both it and bryoidin look very voluminous in water, but
are extremely small in weight, and are present in the drug in but a
very small amount. The composition of bryoidin agrees with the formula
C₂₀H₃₈O₃, which might be written thus (C₅H₈)₄+3OH₂. But it contains
no water of crystallization. In the vapour of dry hydrochloric gas,
bryoidin assumes a fine red colour, turning violet, then blue, and
lastly green. This behaviour is not at all displayed by amyrin.

The liquids from which bryoidin is obtained contain an amorphous
brown substance of intensely bitter taste, at the same time somewhat
aromatic. It is decomposed by dilute mineral acids, evolving a very
peculiar strong odour.

Buri[616] isolated from Manila Elemi an extremely small amount of
_Elemic acid_, C₃₅H₅₆O₄. It is in very brilliant crystals, much larger
than those of the other constituents of elemi. Although we have before
us some prisms of the acids several millimetres long, it has been found
impossible to ascertain their crystallographic character, each of the
prisms being formed of very intimately aggregated crystals. Elemic acid
melts at 215° C.; its alcoholic solution decidedly reddens litmus.
Elemate of potassium is a crystalline salt.

[615] Flückiger, _Pharm. Journ._ v. (1874) 142.

[616] _Pharm. Journ._ viii. (1878) 601.

The relations of the substances hitherto isolated from elemi may
perhaps be given thus:—

    Essential oil,         C₅H₈.
    Amyrin,               (C₅H₈)₅ + OH₂
    Amorphous resin (?)   (C₅H₈)₂ + OH₂
    Bryoidin,             (C₅H₈)₄ + 3OH₂
    Elemic acid,          (C₅H₈)₇ + O₄

=Uses=—Elemi is scarcely used in British medicine except in the form of
an ointment, sometimes prescribed as a stimulating application to old
wounds.

=Other sorts of Elemi=—1. _Mexican Elemi_, _Vera Cruz Elemi_—This drug,
which used to be imported into London about thirty years ago, but which
has now disappeared from commerce, is the produce of a tree named by
Royle _Amyris elemifera_ growing at Oaxaca in Mexico.[617] It is a
light yellow, or whitish, brittle resin occurring in semi-cylindrical
scraped pieces, or in irregular fragments which are sometimes
translucent but more often dull and opaque. It easily softens in the
mouth so that it may be masticated, and has an agreeable terebinthinous
odour. Treated with cold spirit of wine (·828), it breaks down into a
white magma of acicular crystals (_Amyrin_?).

2. _Brazilian Elemi_—Was described as long ago as 1658 by the traveller
Piso, as a substance completely resembling the elemi of the Old World
and applicable to the same purposes. It is the produce of several
trees described as species of _Icica_, as _I. Icicariba_ DC.,[618] _I.
heterophylla_ DC., _I. heptaphylla_ Aublet, _I. guianensis_ Aubl., _I.
altissima_ Aubl.—In New Granada a similar exudation[619] is furnished
by _I. Caranna_ H.B.K.

A specimen in our possession from Pernambuco[620] is a translucent,
greenish yellow, fragrant, terebinthinous resin, which by cold spirit
of wine may be separated into two portions, the one soluble, the other
a mass of colourless acicular crystals. The resin spontaneously exuded
and collected from the trunks, is often opaque and white, grey, or
yellowish, looking not unlike fragments of old mortar. The microscope
shows it to be made up of minute acicular crystals.[621]

3. _Mauritius Elemi_—Fine specimens of this substance and of
_Colophonia Mauritiana_ DC. the tree affording it, were sent to one of
us (H.) in 1855 by Mr. Emile Fleurot of Mauritius. The resin accords in
its general characters with Manila elemi, like which it leaves after
treatment with cold spirit of wine, an abundance of crystals resembling
amyrin.

[617] Royle’s very imperfect specimens of this plant are in the British
Museum.

[618] Now _Protium Icicariba_ Marchand, in _Flora Brasiliensis_,
fascicul. 65 (1874) tab. liii.

[619] G. Planchon, _Bulletin de la Soc. Bot. de France_, xv. (1868) 16.

[620] Given me by Mr. Manley, late of Pernambuco. I have also an
authentic specimen of the resin of _I. heterophylla_ collected at
Santarem, Pará, by Mr. H. W. Bates in 1853.—D. H.

[621] For some experiments on the resin of _Icica_, see Gmelin,
_Chemistry_, xvi. (1866) 421.—Also Stenhouse and Groves, in Liebig’s
_Annalen der Chemie_, 180 (1876) 253, on resin and oil of _Icica
heptaphylla_. The former would appear to agree with the formula
(C₅H₈)₉OH₂.

4. _Luban Meyeti_[622] or _Luban Mati._—This substance, which we claim
to be the _Oriental_ or _African Elemi_ of the older writers, and also
one of the resins anciently designated _Animi_,[623] is the exudation
of _Boswellia Frereana_ Birdwood, a remarkable tree gregarious on the
bare limestone hills near Bunder Murayah to the west of Cape Gardafui.
The tree which is called _Yegaar_ by the natives, is of small stature,
and differs from the other species of _Boswellia_ growing on the same
coast in having glabrous, glaucous leaves with obtuse leaflets, crisped
at the margin.[624] The bark is smooth, papery, and translucent, and
easily stripped off in thin sheets which are used for writing on.
Though growing wild, the trees are said by Capt. Miles[625] to be
carefully watched and even sometimes propagated. The resin exudes after
incision in great plenty, soon hardens, and is collected by the Somali
tribes who dispose of it to traders for shipment to Jidda and ports of
Yemen: occasionally a package reaches London among the shipments of
olibanum. It is used in the East for chewing like mastich.

In modern times Luban Mati has been mentioned by Wellsted in his
“Travels in Arabia” (1838).

_Luban Meyeti_ occurs in the form of detached droppy tears and
fragments, occasionally in stalactitic masses several ounces in weight.
It breaks very easily with a brilliant conchoidal fracture, showing an
internal substance of a pale amber yellow and perfectly transparent.
Externally it is more or less coated with a thin opaque white crust,
which seen under the microscope appears non-crystalline. Many of the
tears have pieces of the thin, brown, papery bark adhering to them.
The resin has an agreeable odour of lemon and turpentine, and a mild
terebinthinous taste.

Treated with alcohol (·838) it is almost entirely dissolved; the very
small undissolved portion is not crystalline. The former agrees with
the formula C₂₀H₃₀O₂. 20 lb. of Luban Mati yielded us 10 ounces of
a volatile oil (= 3·1 per cent.) having a fragrant odour suggestive
of elemi and sp. gr. 0·856 at 17° C. The oil examined in a column
50 millim. long, deviates the ray 2°·5 to the left. By fractional
distillation we found it to consist of dextrogyre hydrocarbon, C₁₀H₁₆,
mixed with an oxygenated oil which we did not succeed in isolating;
the latter is evidently lævogyre, and exists in proportion more than
sufficient to overcome the weak dextrogyre power of the hydrocarbon.

There is no gum in this exudation; it is therefore essentially
different from olibanum, the product of closely allied species of
_Boswellia_.[626]

[622] _Lubán_ is the general Arabic name for olibanum: _meyeti_ perhaps
from Jebel Meyet, a mountain of 1200 feet on the Somali Coast in long.
47° 10′.

[623] By the assistance of Professor G. Planchon we have ascertained
that it is identically the same substance as described by Guibourt
under the name _Tacamaque jaune huileuse_ A.—_Hist. des Drogues_, iii.
(1850) 483.

[624] Figured in Birdwood’s paper, _Trans. Linn. Soc._ xxvii. (1870)
tab. 32; also, (reduced) in Cooke’s report on the _Gums, Resins, etc.,
of the India Museum_, 1874, plate iv.

[625] _Journ. Geograph. Soc._ xlii. (1872) 61.

[626] Flückiger, on Luban Mati and Olibanum, _Pharm. Journ._ viii
(1878) 805, with sketch map of the Somali Coast.




MELIACEÆ.


CORTEX MARGOSÆ.

_Cortex Azadirachtæ_; _Nim Bark_, _Margosa Bark_.

=Botanical Origin=—_Melia indica_ Brandis (_M. Azadirachta_ L.,
_Azadirachta indica_ Juss.), an ornamental tree, 40 to 50 feet high
and attaining a considerable girth,[627] well known throughout India
by its Hindustani name of _Nim_, or by its Portuguese appellation of
_Margosa_.[628] It is much planted in avenues, but occurs wild in the
forests of Southern India, Ceylon and the Malay Archipelago, as far as
Java.[629]

The hard and heavy wood which is so bitter that no insect will attack
it, the medicinal leaves and bark, the fruit which affords an acrid
bitter oil used in medicine and for burning, the gum which exudes from
the stem, and finally a sort of toddy obtained from young trees, cause
the _Nim_ to be regarded as one of the most useful trees of India.

_M. indica_ is often confounded with _M. Azedarach_ L., a native of
China,[630] and probably of India, now widely distributed throughout
the warmer regions of the globe, and not rare even in Sicily and
other parts of the south of Europe. The former has an oval fruit (by
abortion) one-celled and one-seeded, and leaves simply pinnate. The
latter has the fruit five-celled, and leaves bipinnate.

=History=—The tree under the Sanskrit name of _Nimba_ is mentioned
in Susruta, one of the most ancient Hindu medical writings, composed
perhaps about the 10th century of our era.

In common with many other productions of India, it attracted the
notice of Garcia de Orta, physician to the Portuguese viceroy at Goa,
and he published an account of it in his work on drugs in 1563.[631]
Christoval Acosta[632] in 1578 supplied some further details and also a
figure of the tree. The tonic properties of the bark, long recognized
by the native physicians of India, were successively tested by Dr. D.
White of Bombay in the beginning of the present century, and have since
been generally admitted.[633] The drug has a place in the _Pharmacopœia
of India_.

=Description=—The bark in our possession[634] is in coarse fibrous
pieces about ⅕ of an inch thick and 2 to 3 inches wide, slightly
channelled. The suberous coat is rough and cracked, and of a greyish
rusty hue. The inner surface is of a bright buff and has a highly
foliaceous structure. On making a transverse section three distinct
layers may be observed—firstly the suberous coat exhibiting a large
brown parenchyme interwoven with small bands of corky tissue,—secondly
a dark cellular layer, and then the foliaceous liber. The dry bark is
inodorous and has a slightly astringent bitter taste.

[627] Fig. in Bentley and Trimen, _Medic. Plants_, part 27.

[628] From _amargoso_, bitter.

[629] C. De Candolle, in _Monogr. Phanerogamar._ i. (1878) 459.

[630] It is mentioned in Chinese writings dating long prior to the
Christian era.—Bretschneider, _Chinese Botanical Works_, 1870. 12.

[631] _Colloquios dos Simples, &c._, Goa, 1563 _Colloq._ xl. p. 153.

[632] _Tractado de las Drogas y Medicinas de las Indias Orientales_,
Burgos, 1578, cap. 43.

[633] Waring, in _Pharmacopœia of India_, 1868. 443.

[634] We are indebted for it to Mr. Broughton of Ootacamund.

=Microscopic Structure=—The suberous coat consists of numerous
layers of ordinary cork-cells, which cover a layer of nearly cubic
sclerenchymatous cells. This latter however is not always met with,
secondary bands of cork (_rhytidoma_) frequently taking its place. The
liber is commonly built up of strong fibre-bundles traversed by narrow
medullary rays, and transversely separated by bands of parenchymatous
liber tissue. Crystals of oxalate of calcium occur in the parenchyme
more frequently than the small globular starch grains. The structure of
the bark varies considerably according to the gradual development of
the secondary cork-bands.

=Chemical Composition=—Margosa bark was chemically examined in India by
Cornish[635] (1856), who announced it as a source of a bitter alkaloid
to which he gave the name of _Margosine_, but which he obtained only
in minute quantity as a “_double salt of Margosine and Soda_” in long
white needles.

From the bitter oil of the seeds he isolated a substance which he
called _Margosic Acid_, and which he doubted to be capable of affording
crystallizable salts. The composition neither of this acid nor of
margosine is known, nor have the properties of either been investigated.

The small sample of the bark at our disposal only enables us to
add that an infusion produced with perchloride of iron a blackish
precipitate, and that an infusion is not altered by tannic acid or
iodohydrargyrate of potassium. If the inner layers of the bark are
alone exhausted with water, the liquid affords an abundant precipitate
with tannic acid; but if the _entire_ bark is boiled in water, the
tannic matter which it contains will form an insoluble compound with
the bitter principle, and prevent the latter being dissolved. It is
thus evident that to isolate the bitter matter of the bark, it would
be advisable to work on the liber or inner layers alone, which might
readily be done, as they separate easily.

According to the recent researches of Broughton[636] the bitter
principle is an amorphous resin soluble in the usual solvents and in
boiling solutions of fixed alkalis. From the latter it is precipitated
by acids, yet, probably, altered. Broughton ascribed the formula
C₃₆H₅₀O₁₁ to this bitter resin purified by means of bisulphide of
carbon, ether and absolute alcohol; it fused at 92° C. He obtained
moreover a small quantity of a crystallized principle, which he
believed to be a fatty body, yet its melting point of 175° C. is not in
favour of this suggestion.

=Uses=—In India the bark is used as a tonic and antiperiodic, both by
natives and Europeans. Dr. Pulney Andy of Madras has found the leaves
beneficial in small-pox.

[635] _Indian Annals of Medical Science_, Calcutta, iv. (1857) 104.

[636] _Madras Monthly Journ. Med. Science_, quoted in _Pharm. Journ._
June 14, 1873, 992.


CORTEX SOYMIDA.

_Cortex Swieteniæ_; _Rohun Bark_.

=Botanical Origin=—_Soymida[637] febrifuga_ Juss. (_Swietenia
febrifuga_ Willd.), a tree of considerable size not uncommon in the
forests of Central and Southern India. The timber called by Europeans
_Bastard Cedar_ is very durable and strong, and much valued for
building purposes.

=History=—The introduction of Rohun Bark into the medical practice
of Europeans is due to Roxburgh[638] who recommended the drug as a
substitute for Cinchona, after numerous trials made in India about the
year 1791. At the same time he sent supplies to Edinburgh, where Duncan
made it the subject of a thesis[639] which probably led to it being
introduced into the materia medica of the Edinburgh Pharmacopœia of
1803, and of the Dublin Pharmacopœia of 1807.

Though thus officially recognized, it does not appear that the bark
came much into use or by any other means fulfilled the expectations
raised in its favour. At present it is regarded simply as a useful
astringent tonic, and as such it has a place in the _Pharmacopœia of
India_ (1868).

=Description=—Our specimen of Rohun bark[640] which is from a young
tree, is in straight or somewhat curved, half-tubular quills, an inch
or more in diameter and about ⅕ of an inch in thickness. Externally
it is of a rusty grey or brown, with a smoothish surface exhibiting
no considerable furrows or cracks, but numerous small corky warts.
These form little elliptic scars or rings, brown in the centre and
but slightly raised from the surface. The inner side and edges of the
quills are of a bright reddish colour.

A transverse section exhibits a thin outer layer coloured by
chlorophyll, and a middle layer of a bright rusty hue, traversed by
large medullary rays and darker wedge-shaped rays of liber. The latter
has a fibrous fracture, that of the outer part of the bark being
rather corky or foliaceous. The whole bark when comminuted is of a
rusty colour, becoming reddish by exposure to air and moisture. It has
a bitter astringent taste with no distinctive odour. The older bark
frequently half an inch thick and fibrous, has a thick ragged corky
layer of a rusty blackish-brown colour, deeply fissured longitudinally,
and minutely cracked transversely. Old bark, according to Dymock
(1877), is generally in half quills of a rich red-brown colour.

=Microscopic Structure=—The bark presents but few structural
peculiarities. The ring of liber is made up of alternating
prosenchymatous and parenchymatous tissue. In the latter the
larger cells are filled with mucilage, the others with starch. The
prosenchymatous groups of the liber exhibit that peculiar form we have
already described as _hornbast_ (p. 74); it chiefly contains the tannic
matter, besides stellate crystals of oxalate of calcium which are
distributed through the whole tissue of the bark. The medullary rays
are of the usual form, and contain starch granules. The corky coat is
built up of a smaller number of vaulted cells.

[637] From _Sómida_, the Teluga name of the tree; _Róhan_ is its name
in Hindustani.—Fig. in Bentley and Trimen, _Med. Plants_, part 18
(1877).—See also C. De Candolle, in _Monogr. Phanerogamar._ i. (1878)
722.

[638] _Medical Facts and Observations_, Lond. vi. (1795) 127.

[639] _Tentamen inaugurale de Swieteniâ Soymidâ_, Edinb. 1794.

[640] Kindly sent us by Mr. Broughton of Ootacamund.

=Chemical Composition=[641]—The bitter principle of the bark has been
ascertained by Broughton[642] to be a nearly colourless resinous
substance, sparingly soluble in water but more so in alcohol, ether, or
benzol. It does not appear to unite with acids or bases, and is less
soluble in water containing them than in pure water. It has a very
bitter taste, and refuses to crystallize either from benzol or ether.
It contains no nitrogen. To this we may add that the bark is rich in
tannic acid.

=Uses=—Rohun bark is administered in India as an astringent tonic
and antiperiodic, and is reported useful in intermittent fevers and
general debility, as well as in the advanced stages of dysentery and in
diarrhœa.




RHAMNACEÆ.


FRUCTUS RHAMNI.

_Baccæ Rhamni, Baccæ Spinæ cervinæ; Buckthorn Berries_; F. _Baies de
Neprun_; G. _Kreuzdornbeeren_.

=Botanical Origin=—_Rhamnus cathartica_ L., a robust diœcious shrub
with spreading branches, the smaller of which often terminate in a
stout thorn. It is indigenous to Northern Africa, the greater part of
Europe, and stretches eastward to the Caucasus and into Siberia. We
have seen stems 50 years old, having a diameter of 8 inches, sent from
the government of Cherson, Southern Russia. In England the buckthorn
though generally distributed is abundant only in certain districts;
in Scotland it occurs wild in but a single locality. Yet in Norway,
Sweden, and Finland it grows much further north.

The fruit which ripens in the autumn is collected for use chiefly in
the counties of Hertfordshire, Buckinghamshire, Oxfordshire, and also
from Wiltshire. The collectors usually prefer to supply the juice as
expressed by themselves.

=History=—The Buckthorn was well known to the Anglo-Saxons, and is
mentioned as _Hartsthorn_ or _Waythorn_ in their medical writings and
glossaries dating before the Norman conquest. The Welsh physicians of
Myddfai (“Meddygon Myddvai”) in the 13th century prescribed the juice
of the fruit of buckthorn boiled with honey as an aperient drink.

As _Spina Cervina_ the shrub is referred to by Piero de’ Crescenzi of
Bologna[643] about A.D. 1305.

[641] The analysis alluded to in the _Pharm. of India_ (p. 444)
concerns _Khaya_ (_Swietenia_) _senegalensis_, and not the present
species, as my friend Dr. Overbeck has informed me.—F. A. F.

[642] Beddome, _Flora Sylvatica_, Madras, part i. (1869) 8,—also
information communicated direct.

[643] _Trattato dall’ Agricoltura_, Milano, 1805, 10. iii. c. 58.

The medicinal use of the berries was familiar to all the writers on
botany and materia medica of the 16th century. Syrup of buckthorn first
appeared in the London Pharmacopœia of 1650; it was aromatized by means
of aniseed, cinnamon, mastich and nutmeg.

=Description=—The fruits, which are only used in the fresh state, are
small, juicy, spherical drupes the size of a pea, black and shining,
bearing on the summit the remnants of the style, and supported below
by a slender stalk expanded into a disc-like receptacle. Before
ripening the fruit is green and distinctly 4-lobed, afterwards smooth
and plump. It contains 4 one-seeded nuts[644] meeting at right angles
in the middle. The seed is erect with a broad furrow on the back: in
transverse section the albumen and cotyledons are seen to be curved
into a horseshoe form with the ends directed outwards.

The fresh juice is green, has an acid reaction and a sweetish,
afterwards disagreeably bitter taste, and repulsive odour. It is
coloured dingy green by ferric chloride, yellow by alkalis, red by
acids. According to Umney[645] it should have a sp. gr. of 1·070 to
1·075, but is seldom sold pure. By keeping the juice gradually turns
red.

=Microscopic Structure=—The epidermis consists of small tabular cells,
followed by a row of large cubic cells and then by several layers of
tangentially-extended cells rich in chlorophyll. This thick epicarp
passes into the loose thin-walled and large-celled sarocarp. Besides
chlorophyll it exhibits numerous cells each containing a kind of sac,
which may be squeezed out of the cell. These sacs are violet, turning
blue with alkalis. Similar, yet much more conspicuous bodies occur also
in the pulp of the Locust Bean (_Ceratonia Siliqua_ L.).

=Chemical Composition=—The berries of buckthorn and other species
of _Rhamnus_ contain interesting colouring matters, which have been
the subject of much chemical research and controversy. Winckler
in 1849 extracted from the juice _Rhamnocathartin_, a yellowish
uncrystallizable bitter substance, soluble in water but not in ether.
Alkalis colour it golden yellow; perchloride of iron, dark greenish
brown.

In 1840 Fleury, a pharmacien of Pontoise, discovered in buckthorn
juice a yellow substance forming cauliflower-like crystals to which
he gave the name of _Rhamnine_. This body has been recently studied
by Lefort,[646] who identified it with the _Rhamnetine_ of Galletly
(1858) and the _Chrysorhamnine_ of Schützenberger and Bertèche (1865).
Though obtainable from the berries of all kinds of _Rhamnus_ used in
dyeing (including the common buckthorn), it is got most easily and
abundantly from Persian Berries. When pure, and crystallized from
absolute alcohol, it is described as forming minute yellow translucent
tables. It is scarcely soluble in cold water, though colouring it pale
yellow; is soluble in hot alcohol, insoluble in ether or bisulphide of
carbon. It is very soluble in caustic alkalis, forming uncrystallizable
reddish-yellow solutions. From alkaline solutions it is precipitated
by a mineral acid in the form of a glutinous magma resembling hydrated
silica. Lefort assigns to it the formula C₁₂H₁₂O₅ + 2H₂O.

[644] In _Rh. Frangula_ L., the other British species, the fruit has 2
nuts.

[645] _Pharm. Journ._ Nov. 23 (1872) 404, and July 11 (1874) 21.

[646] _Sur les graines des Nerpruns tinctoriaux._—_Journ. de Pharm._
iv. (1866) 420.—See also the investigations of Liebermann and Hörmann,
1879.

This chemist has likewise found in the berries of _Rhamnus_, though
not with certainty in those of _R. cathartica_, a neutral substance
isomeric with rhamnine, to which he has given the name of _Rhamnegine_.
Unlike rhamnine it is very soluble in cold water, but in all other
respects it agrees with that body in chemical and physical properties.
The two substances have the same taste, almost the same tint, the same
crystalline form, and lastly they give rise to the same reactions with
chemical agents.

The conclusions of Lefort have been contested by Stein (1868) and by
Schützenberger (1868), the latter of whom succeeded in decomposing
rhamnegine and proving it a glucoside having the formula C₂₄H₃₂O₁₄. Its
decomposition gives rise to a body named _Rhamnetin_, C₁₂H₁₀O₅, and
a crystallizable sugar isomeric with mannite. Schützenberger admits
that the berries contain an isomeric modification of rhamnegine; but
in addition another colouring matter insoluble in water, which appears
to be the _Rhamnine_ of Lefort, but to which he assigns a different
formula, namely, C₁₈H₂₂O₁₀. This is also a glucoside capable of
being split into rhamnetin and a sugar. There are thus, according to
Schützenberger, two forms of rhamnegine which may be distinguished as α
and β, and there is the substance insoluble in water, named by Lefort
_Rhamnine_.

The question of the purgative principles of buckthorn, it will be
observed, has not been touched by all these researches.

=Uses=—From the juice of the berries is prepared a syrup having
strongly purgative properties, much more used as a medicine for animals
than for man. The pigment _Sap Green_ is also made from the juice.




AMPELIDEÆ.


UVÆ PASSÆ.

_Passulæ majores_; _Raisins_; F. _Raisins_; G. _Rosinen_.

=Botanical Origin=—_Vitis vinifera_ L., the Common Grape-vine. It
appears to be indigenous to the Caucasian provinces of Russia, that is
to say, to the country lying between the eastern end of the Black Sea
and the south-western shores of the Caspian; extending thence southward
into Armenia. Under innumerable varieties, it is cultivated in most of
the warmer and drier countries of the temperate regions of both the
northern and southern hemispheres. Humboldt defines the area of the
profitable culture of the vine as a zone lying between 36° and 40° of
north latitude.

=History=—The vine is among the oldest of cultivated plants, and
is mentioned in the earliest Mosaic writings. _Dried_ grapes as
distinguished from _fresh_ were used by the ancient Hebrews, and in
the Vulgate are translated _Uvæ passæ_.[647] During the middle ages,
raisins were an article of luxury imported into England from Spain.

[647] Numbers vi. 3; 1 Sam. xxv. 18, xxx. 12; 2 Sam. xvi. 1; 1 Chron.
xii. 40.

=Description=—The ovary of _Vitis vinifera_ is 2-celled with 2 ovules
in each cell; it develops into a succulent, pedicellate berry of
spherical or ovoid form, in which the cells are obliterated and some of
the seeds generally abortive. As the fruit is not articulated with the
rachis or the rachis with the branch, it does not drop at maturity but
remains attached to the plant, on which, provided there is sufficient
solar heat, it gradually withers and dries: such fruits are called
_Raisins of the sun_. Various methods are adopted to facilitate the
drying of the fruit, such as dipping the bunches in boiling water or in
a lye of wood ashes, or twisting or partially severing the stalk,—the
effect of each operation being to arrest or destroy the vitality of
the tissues. The drying is performed by exposure to the sun, sometimes
supplemented by artificial heat.

The raisins commonly found in the shops are the produce of Spain and
Asia Minor, and are sold either in entire bunches or removed from the
stalk. The former kind, known as _Muscatel Raisins_ and imported from
Malaga, are dried and packed with great care for use as a dessert
fruit. The latter kind, which includes the _Valencia Raisins_ of Spain,
and the _Eleme_, _Chesme_ and stoneless _Sultana Raisins_ of Smyrna,
are used for culinary purposes. For pharmacy, Valencia raisins are
generally employed.

=Microscopic Structure=—The outer layer or skin of the berry is made
up of small tabular cells loaded with a reddish granular matter, which
on addition of an alcoholic solution of perchloride of iron assumes a
dingy green hue. The interior parenchyme exhibits large, thin-walled,
loose cells containing an abundance of crystals (bitartrate of
potassium and sugar). There are also some fibro-vascular bundles
traversing the tissue in no regular order.

=Chemical Composition=—The pulp abounds in grape sugar and cream
of tartar, each of which in old raisins may be found crystallized
in nodular masses; it also contains gum and malic acid. The seeds
afford 15 to 18 per cent. of a bland fixed oil, which is occasionally
extracted. Fitz[648] has shown that it consists of the glycerides
of _Erucic Acid_, C₂₂H₄₂O₂, stearic acid, and palmitic acid, the
first-named acid largely prevailing. The crystals of erucic acid melt
at 34° C.; by means of fused potash they may be resolved into arachic
acid, C₂₀H₄₀O₂, and acetic acid, C₂H₄O₂.

The seeds further contain 5 to 6 per cent. of tannic acid, which also
exists in the skin of the fruit. The latter is likewise the seat of
chlorophyll and other colouring matter.

=Commerce=—The consumption of raisins in Great Britain is very large
and is increasing. The imports into the United Kingdom have been as
follows:—

        1870.         1871.            1872.             1876.
       365,418       427,056          617,418           583,860 cwt.
    val. £593,527.  val. £707,344.   val. £1,149,337.   val. £1,058,406.

Of the quantity mentioned for 1872 there were 400,570 cwt. shipped
from Spain, 176,500 cwt. from Asiatic Turkey, and the remainder from
other countries.[649] It is stated that Greece, in 1874, exported about
1⅓ millions of cwt., value £28,000,000; much of this was shipped to
England.

[648] _Berichte der deutsch. chem. Gesellsch. zu Berlin_, iv. (1871)
442.

[649] _Annual Statement of the Trade of the United Kingdom._

=Uses=—Raisins are an ingredient of Compound Tincture of Cardamoms and
of Tincture of Senna. They have no medicinal properties, and are only
used for the sake of the saccharine matter they impart.[650]




ANACARDIACEÆ.


MASTICHE.

_Mastix_, _Resina Mastiche_; _Mastich_; F. _Mastic_; G. _Mastix_.

=Botanical Origin=—_Pistacia Lentiscus_ L., the lentisk, is a diœcious
evergreen, mostly found as a shrub a few feet high; but when allowed
to attain its full growth, it slowly acquires the dimensions of a
small tree having a dense head of foliage. It is a native of the
Mediterranean shores from Syria to Spain, and is found in Portugal,
Morocco and the Canaries. In some parts of Italy it is largely cut for
fuel.

Mastich is collected in the northern part of the island of Scio, which
was long regarded as the only region in the world capable of affording
it. Experiments made in 1856 by Orphanides[651] have proved that
excellent mastich might be easily obtained in other islands of the
Archipelago, and probably also in Continental Greece. The same botanist
remarks that the trees yielding mastich in Scio are exclusively _male_.

=History=—Mastich has been known from a very remote period, and is
mentioned by Theophrastus,[652] who lived in the 4th century before the
Christian era. Both Dioscorides and Pliny notice it as a production of
the island of Chio, the modern Scio.

Avicenna[653] described (about the year 1000) two sorts of mastich,
the white or Roman (i.e. _Mediterranean_ or _Christian_), and the dark
or Nabathæan,—the latter probably one of the Eastern forms of the drug
mentioned at p. 165.

Benjamin of Tudela,[654] who visited the island of Scio when travelling
to the East about A.D. 1160-1173, also refers to it yielding mastich,
which in fact has always been one of its most important productions,
and from the earliest times intimately connected with its history.

Mastich was prescribed in the 13th century by the Welsh “Meddygon
Myddvai” as an ingredient of ointments.

[650] The amount of this is very small. On macerating crushed raisins
in proof spirit in the proportion of 2 oz. to a pint, we found each
fluid ounce of the tincture so obtained to afford by evaporation to
dryness 28 grains of a dark viscid sugary extract.

[651] Heldreich, _Nutzpflanzen Griechenlands_, Athen, 1862. 61.

[652] _Hist. Plant._ lib. ix. c. 1.

[653] Lib. ii. c. 462.

[654] Wright, _Early Travels in Palestine_, 1848. 77. (Bohn’s series).

In the middle ages the mastich of Scio was held as a monopoly by the
Greek emperors, one of whom, Michael Paleologus in 1261, permitted the
Genoese to settle in the island. His successor Andronicus II. conceded
in 1304 the administration of the island to Benedetto Zaccaria, a
rich patrician of Genoa and the proprietor of the alum works of Fokia
(the ancient Phocæa), north-west of Smyrna, for ten years, renouncing
all tribute during that period. The concession was very lucrative, a
large revenue being derived from the _Contrata del Mastico_ or Mastich
district: and the Zaccaria family, taking advantage of the weakness of
the emperor, determined to hold it as long as possible. In fact they
made themselves the real sovereigns of Scio and of some of the adjacent
islands, and retained their position until expelled by Andronicus III.
in 1329.[655]

The island was retaken by the Genoese under Simone Vignosi in 1346;
and then by a remarkable series of events became the property of
an association called the _Maona_ (the Arabic word for subsidy or
reinforcement). Many of the noblest families of Genoa enrolled
themselves in this corporation and settled in the island of Scio;
and in order to express the community of interest that governed
their proceedings, some of them relinquished their family names and
assumed the general name of _Giustiniani_.[656] This extraordinary
society played a part exactly comparable to that of the late East
India Company. In Genoa it had its “_Officium Chii_”; it had its own
constitution and mint, and it engaged in wars with the emperors of
Constantinople, the Venetians and the Turks, who in turn attacked and
ravaged the mastich island and adjacent possessions.

The Giustinianis regulated very strictly the culture of the lentisk
and the gathering and export of its produce, and cruelly punished all
offenders. The annual export of the drug was 300 to 400 quintals,[657]
which were immediately assigned to the four regions with which
the Maona chiefly traded. These were _Romania_ (_i.e._ Greece,
Constantinople and the Crimea), _Occidente_ (Italy, France, Spain and
Germany), _Vera Turchia_ (Asia Minor), and _Oriente_ (Syria, Egypt, and
Northern Africa). In 1364, a quintal was sold for 40 _lire_; in 1417,
the price was fixed at 25 _lire_. In the 16th century, the whole income
from the drug was 30,000 ducats (£13,750),[658] a large sum for that
period.

In 1566, the Giustinianis definitively lost their beautiful island, the
Turks under Piali Pasha taking it by force of arms under pretext that
the customary tribute was not duly paid.[659] A few years before that
event, it was visited by the French naturalist Belon[660] who testifies
from personal observation to the great care with which the lentisk was
cultivated by the inhabitants.

[655] Friar Jordanus who visited Scio _circa_ 1330 (?) noticed the
production of mastich, and also the loss of the island by Martino
Zaccaria.—_Mirabilia descripta, or Wonders of the East_, edited by Col.
Yule for the Hakluyt Society, 1863.

[656] Probably partly for the reason that a Palazzo Giustiniani in
Genoa had become the property of the Society. In the little “Piazza
Giustiniani,” near the cathedral of San Lorenzo, that palace may still
be seen, but there is only a large view of the island of Scio which
would remind of the Maona. I was told in 1874 by Sig. Canale, the
historian of Genoa, that he thought it doubtful that the _Officium
Chii_ had resided in the said palace.—F. A. F..

[657] An incidental notice showing the value of the trade occurs in the
letter of Columbus (himself a Genoese) announcing the result of his
first voyage to the Indies. In stating what may be obtained from the
island of Hispaniola, he mentions—gold and spices ... and _mastich_,
hitherto found only in Greece in the island of Scio, and which the
Signoria sells at its own price, as much as their Highnesses (Ferdinand
and Isabella) shall command to be shipped. The letter bears date 15
Feb. 1493.—_Letters of Christobal Columbus_ (Hakluyt Society) 1870. p.
15.

[658] The ducat being reckoned at 9_s_. 2_d_.

[659] For further particulars respecting the history of Scio, the
Maona, and the trade of the Genoese in the Levant, see Hopf in
Ersch and Grubber’s _Encyclopädie_, vol. 68 (Leipzig, 1859) art.
_Giustiniani_; also Heyd _Colonie commerciali degli Italiani in
Oriente_ i. (1866).

[660] _Observations de plusieurs singularitez et choses mémorables
trouvées en Grèce_, etc. Paris, 1554. liv. ii. ch. 8. p. 836.

When Tournefort[661] was at Scio in 1701, all the lentisk trees on
the island were held to be the property of the Grand Signor, and if
any land was sold, the sale did not include the lentisks that might
be growing on it. At that time the mastich villages, about twenty in
number, were required to pay 286 chests of mastich annually to the
Turkish officers appointed to receive the revenue.

In the beginning of the present century, when Olivier[662] paid a visit
to the island of Chios, he found 50,000 ocche (one occa = 2·82 lb.
avdp. = 1·28 kilogrammes) or somewhat more to be the annual harvest of
mastich.

The month of January, 1850, was memorable throughout Greece and the
Archipelago for a frost of unparalleled severity which proved very
destructive to the mastich trees of Scio, and occasioned a scarcity of
the drug that lasted for many years.[663]

The foregoing statements show that for centuries past Scio or Chios
was famed for this resin; there are however a few evidences proving
that at least a little mastich used also to be collected in other
islands. Amari[664] quoted an Arabic geographer of the 12th century
speaking of “_il mastice di Pantellaria cavato da’ lentischi e lo
storace odorifero_.” Pantellaria, Kossura of the ancients, is the
small volcanic island south-west of Sicily, not far from Tunis. In
a list enumerating the drugs to be met with in 1582 in the fair of
Frankfurt[665] we find even mastich of _Cyprus_ quoted as superior to
the common. Cyprian mastich again occurs in the pharmaceutical tariffs
of 1612 and 1669 of the same city, and in many others of that time.[666]

The disuse into which mastich has fallen makes it difficult to
understand its ancient importance; but a glance at the pharmacopœias of
the 15th, 16th, and 17th centuries shows that it was an ingredient of a
large number of compound medicines.[667]

=Secretion=—In the bark of the stems and branches of the mastich shrub,
there are resin-ducts like those in the aromatic roots of _Umbelliferæ_
or _Compositæ_. In _Pistacia_ they may even be shown in the petioles.
The wood is devoid of resin,[668] so that slight incisions are
sufficient to provoke the resinous exudation, the bark being not very
thick, and liable to scale off.

[661] _Voyage into the Levant_, i. (1718) 285.

[662] _Voyage dans l’Empire Othoman et la Perse_, ii. (Paris, 1801)
132-136.

[663] At Athens the mercury was for a short time at -10° C. (14° F.)
In Scio, where the frost was probably quite as severe, though we have
no exact data, the mischief to the lentisks varied with the locality,
trees exposed to the north or growing at considerable elevations, being
killed down to the base of the trunk, while those in more favoured
positions suffered destruction only in some of their branches.

[664] _Storia dei Musulmani di Sicilia_, iii. (1872) 787.

[665] Flückiger, _Documente zur Geschichte der Pharmacie_, Halle, 1876.
31.

[666] _Ibid._ 41. 65.

[667] Thus in the _London Pharmacopœia_ of 1632, mastich enters into 24
of the 37 different kinds of pill, besides which it is prescribed in
troches and ointments.

[668] See Unger and Kotsehy, _Die Insel Cypern_, Wien, 1865. 424.

=Collection=—In Scio incisions are made about the middle of June in the
bark of the stems and principal branches. From these incisions which
are vertical and very close together, the resin speedily flows, and
soon hardens and dries. After 15 to 20 days it is collected with much
care in little baskets lined with white paper or clean cotton wool. The
ground below the trees is kept hard and clean, and flat pieces of stone
are often laid on it that the droppings of resin may be saved uninjured
by dirt. There is also some spontaneous exudation from the small
branches which is of very fine quality. The operations are carried on
by women and children and last for a couple of months. A fine tree may
yield as much as 8 to 10 pounds of mastich.

The dealers in Scio distinguish three or four qualities of the drug,
of which the two finer are called κυλιστὸ and ϕλισκάρι, that collected
from the ground πῆττα, and the worst of all ϕλοῦδα.[669]

=Description=—The best sort of mastich consists of roundish tears
about the size of small peas, together with pieces of an oblong or
pear-shaped form. They are of a pale yellow or slightly greenish
tint darkening by age, dusty and slightly opaque on the surface but
perfectly transparent within. The mastich of late imported has been
washed; the tears are no longer dusty, but have a glassy transparent
appearance. Mastich is brittle, has a conchoidal fracture, a slight
terebinthinous balsamic odour. It speedily softens in the mouth, and
may be easily masticated and kneaded between the teeth, in this respect
differing from sandarac, a tear of which breaks to powder when bitten.

Inferior mastich is less transparent, and consists of masses of larger
size and less regular shape, often contaminated with earthy and
vegetable impurities.

The sp. gr. of selected tears of mastich is about 1·06. They soften at
99° C. but do not melt below 108°.

Mastich dissolves in half its weight of pure warm acetone and then
deviates the ray of polarized light to the right. On cooling, the
solution becomes turbid. It dissolves slowly in 5 parts of oil of
cloves, forming even in the cold a clear solution; it is but little
soluble in glacial acetic acid or in benzol.

=Chemical Composition=—Mastich is soluble to the extent of about 90 per
cent in cold alcohol; the residue, which has been termed _Masticin_ or
_Beta-resin of Mastich_, is a translucent, colourless, tough substance,
insoluble in boiling alcohol or in solution of caustic alkali, but
dissolving in ether or oil of turpentine. According to Johnston, it is
somewhat less rich in oxygen than the following.

The soluble portion of mastich, called _Alpha-resin of Mastich_,
possesses acid properties, and like many other resins has the formula
C₂₀H₃₂O₃. Hartsen[670] asserts that it can be obtained in crystals. Its
alcoholic solution is precipitated by an alcoholic solution of neutral
acetate of lead. Mastich contains a very little volatile oil.

[669] Heldreich (and Orphanides) _Nutzpflanzen Griechenlands_, Athen,
1862, 60.

[670] _Berichte der deutschen chem. Gesellsch._ 1876. 316.

=Commerce=—Mastich still forms the principal revenue of Scio, from
which island the export in 1871 was 28,000 lb. of _picked_, and
42,000 lb. of _common_. The market price of picked mastich was equal
to 6_s_. 10_d_. per lb.—that of common 2_s_. 10_d_. The superior
quality is sent to Turkey, especially Constantinople, also to Trieste,
Vienna, and Marseilles, and a small quantity to England. The common
sort is employed in the East in the manufacture of _raki_ and other
cordials.[671]

=Uses=—Mastich is not now regarded as possessing any important
therapeutic virtues, and as a medicine is becoming obsolete. Even in
varnish making it is no longer employed as formerly, its place being
well supplied by less costly resins, such for example as dammar.

=Varieties=—There is found in the Indian bazaars a kind of mastich
which though called _Mustagi-rúmí_ (Roman mastich), is not imported
from Europe but from Kabul, and is the produce of _Pistacia Khinjuk_
Stocks, and the so-called _P. cabulica_ St. trees growing all over
Sind, Belúchistan and Kabul.[672] This drug, of which the better
qualities closely approximate to the mastich of Scio, sometimes appears
in the European market under the name of _East Indian_ or _Bombay
Mastich_. We find that when dissolved in half its weight of acetone or
benzol, it deviates the ray of light to the right.

The solid resin of the Algerian form of _P. Terebinthus_ L., known as
_P. atlantica_ Desf., is collected and used as mastich by the Arab
tribes of Northern Africa.[673]


TEREBINTHINA CHIA

_Terebinthina Cypria_; _Chian or Cyprian Turpentine_; F. _Térébenthine
ou Baume de Chio ou de Chypres_; G. _Chios Terpenthin_, _Cyprischer
Terpenthin_.

=Botanical Origin=—_Pistacia Terebinthus_ L. (P. _atlantica_ Desf.,
_P. palæstina_ Boiss., _P. cabulica_ Stocks), a tree 20 to 40 feet or
more in height, in some countries only a shrub, common on the islands
and shores of the Mediterranean as well as throughout Asia Minor,
extending, as _P. palæstina_, to Syria and Palestine; and eastward,
as _P. cabulica_, to Belúchistan and Afghanistan. It is found under
the form called _P. atlantica_ in Northern Africa, where it grows to a
large size, and in the Canary Islands.

These several forms are mostly regarded as so many distinct species;
but after due consideration and the examination of a large number of
specimens both dried and living, we have arrived at the conclusion that
they may fairly be united under a single specific name. The extreme
varieties certainly present great differences of habit, as anyone would
observe who had compared _Pistacia Terebinthus_ as the straggling bush
which it is in Languedoc and Provence, with the noble umbrageous tree
it forms in the neighbourhood of Smyrna. But the different types are
united by so many connecting links, that we have felt warranted in
dissenting from the opinion usually held respecting them.

On the branches of Pistacia Terebinthus, a kind of galls is produced,
which we shall briefly notice in our article Gallæe halepenses.

[671] Consul Cumberbatch, _Report on Trade of Smyrna_ for 1871.—_Raki_,
derived from the Turkish word _sâqiz_, for mastich, which, strange to
say, would appear to have its home on the Baltic. In the vocabularies
of the Old-Prussian idiom “sachis” is found meaning resin.—Blau,
_Zeitschrift der Deutschen Morgenl. Gesellsch._, xxix. 582.

[672] Powell, _Economic Products of the Punjab_, Roorkee, 1868. 411.

[673] Guibourt, _Hist. d. Drog._ iii. (1850) 458; Armieux, _Topographie
médicale du Sahara_, Paris, 1866. 58.

=History=—The terebinth was well known to the ancients; it is the
τέρμινθος of Theophrastus, τερέβινθος of other authors, and the _Alah_
of the Old Testament.[674] Among its products, the kernels were
regarded by Dioscorides as unwholesome, though agreeable in taste. By
pressing them, the original _Oil of Turpentine_, τερεβίνθινον ἔλαιον,
a mixture of essential and fat oil was obtained, as it is in the East
to the present day. The resinous juice of the stem and branches, the
true, primitive turpentine, ῤητίνη τερμινθίνη, was celebrated as the
finest of all analogous products, and preferred both to mastich and the
pinic resins. To the latter however the name of turpentine was finally
applied.[675]

=Collection=—The resinous juice is secreted in the bark, according to
Unger,[676] and Marchand,[677] in special cells precisely as mastich in
_P. Lentiscus_. That found in commerce is collected in the island of
Scio. To some extent it exudes spontaneously, yet in greater abundance
after incisions made in the stems and branches. This is done in spring,
and the resin continues to flow during the whole summer; but the
quantity is so small that not more that 10 or 11 ounces are obtained
from a large tree in the course of a year. The turpentine, hardened
by the coolness of the night, is scraped from the stem down which it
has flowed, or from flat stones placed at the foot of the tree to
receive it. As it is, when thus collected, always mixed with foreign
substances, it is purified to some extent by straining through small
baskets, after having been liquefied by exposure to the sun.

When Tournefort[678] visited Scio in 1701, the island was said to
produce scarcely 300 okes or ocche (one occa = 2·82 lb. avdp.); a
century later Olivier[679] stated, that the turpentine was becoming
very scarce, 200 ocche only, or even less, being the annual yield. It
was then carefully collected by means of little earthen vessels tied to
the incised stems. The trade is asserted to be now almost exclusively
in the hands of the Jews, who dispose of the drug in the interior part
of the Turkish Empire.[680]

=Description=—A specimen collected by Maltass near Smyrna in 1858 was,
after ten years, of a light yellowish colour, scarcely fluid though
perfectly transparent, nearly of the odour of melted colophony or
mastich, and without much taste. We found it readily soluble in spirit
of wine, amylic alcohol, glacial acetic acid, benzol, or acetone, the
solution in each case being very slightly fluorescent. The alcoholic
solution reddens litmus, and is neither bitter nor acrid. Two parts of
this genuine turpentine dissolved in one of acetone deviate a ray of
polarized light 7° to the right[681] in a column 50 mm. long.

[674] Genesis xii. 6, where the word is rendered in our version _plain_.

[675] Further historical information on the Terebinth may be found in
Hehn’s _Kulturpflanzen und Hausthiere_, Berlin, 1877. 336.

[676] Unger u. Kotschy, _die Insel Cypern_, 1865. 361. 424.

[677] _Revision du groupe des Anacardiacées._ Paris, 1869. 150. Plate
iii. shows the resiniferous ducts of a branch two years old.

[678] _Voyage into the Levant_, i. (1718) 287.

[679] _Voy. dans l’Empire Othoman_, etc., ii. (1801) 136.

[680] Maltass, _Pharm. Journ._ xvii. (1856) 540.

[681] A solution of mastich made in the same proportion deviates 3° to
the right.

Chian turpentine as found in commerce and believed to be genuine,
is a soft solid, becoming brittle, by exposure to the air; viewed
in mass it appears opaque and of a dull brown hue. If pressed while
warm between two slips of glass, it is seen to be transparent, of a
yellowish-brown, and much contaminated by various impurities in a state
of fine division. It has an agreeable, mild terebinthinous odour and
very little taste. The whitish powder with which old Chian turpentine
becomes covered, shows no trace of crystalline structure when examined
under the microscope.

=Chemical Composition=—Chian turpentine consists of resin and essential
oil. The former is probably identical with the _Alpha-resin_ of
mastich. The _Beta-resin_ or _Masticin_ appears to be absent, for we
find that Chian turpentine deprived of its essential oil by a gentle
heat, dissolves entirely (impurities excepted) in alcohol sp. gr.
0·815, which is by no means the case with mastich.

The essential oil which we obtained by distilling with water 64 ounces
of Chian turpentine of authentic origin, amounted to nearly 14½ per
cent. It has the odour of the drug; sp. gr. 0·869; boiling point 161°
C.; it deviates the ray of polarized light 12·1° to the right. In
common with turpentine oils of the _Coniferæ_, it contains a small
amount of an oxygenated oil, and is therefore vividly attacked by
sodium. When this reaction is over and the oil is again distilled,
it boils at 157° C. and has a sp. gr. of 0·862. It has now a more
agreeable odour, resembling a mixture of cajuput, mace, and camphor,
and nearly the same rotatory power (11·5° to the right). By saturation
with dry hydrochloric acid, it yields a solid compound after some
weeks. After treatment with sodium and rectification, the oil was
found[682] to consist of C 88·75, H 11·40 per cent., which is the
composition of oil of turpentine.

=Uses=—Chian Turpentine appears to have exactly the properties of the
pinic turpentines; in British medicine it is almost obsolete. In Greece
it is sometimes added to wine or used to flavour cordials, in the same
manner as turpentine of the pine, or mastich.


GALLÆ CHINENSES SEU JAPONICÆ.

=Botanical Origin=—The plant which bears this important kind of gall,
is _Rhus semialata_ Murray (_Rh. Bucki-amela_ Roxb.), a tree attaining
30 to 40 feet, common in Northern India, China and Japan, ascending in
the outer Himalaya and the Kasia hills to elevations of 2,500 to 6,000
feet.[683]

=History=—In China these galls are probably known and used both
medicinally and in dyeing since very long; they are mentioned in the
herbal Puntsaou, written in the middle of the 16th century. They also
occur in Cleyer’s “Specimen medicinæ sinicæ,” Frankfort, 1682, No.
225, under the name _u poi çu_.[684] Kämpfer[685] also mentions a tree
“Baibokf, vulgo Fusi,” growing on the hills, the pinnate leaves of
which he found often provided with an excrescence: “Ἐπίϕνσι foliorum
informi, tuberosa, multiplici, tenui, dura, cava, Gallæ nostratis usu
praestante.” No doubt this refers to the galls under notice; they began
to be imported into Europe about 1724, and are noticed by Geoffroy[686]
as _Oreilles des Indes_, but they seem to have soon disappeared from
the market. Pereira directed attention to them in 1844, since which
time they have formed a regular and abundant article of import both
from China and Japan.

[682] From analysis performed in my laboratory by Dr. Kraushaar.—F. A.
F.

[683] Wight, _Icones Plantar. Indiæ orientalis_, ii. (Madras, 1843)
tab. 561, gives a good figure.

[684] Hanbury, _Science Papers_, 266.

[685] _Amœnitates exoticæ_, 1712. 895.

[686] _Mém. de l’Académie royale des Sciences_, Paris, 1724. 324.—Also
Du Halde, _Description de l’Empire de la Chine_, iii. (La Haye, 1736)
615-625. “Des Ou Poey tsé.” The author quotes numerous medicinal
applications for these galls.

=Formation=—Chinese galls are vesicular protuberances formed on the
leafstalks and branches of the above-mentioned tree, by the puncture
of an insect, identified and figured by Doubleday[687] as a species
of _Aphis_, and subsequently named provisionally by Jacob Bell[688]
_A. chinensis_. We have no account by any competent observer of their
growth; and as to their development, we can only imagine it from the
analogous productions seen in Europe. According to Doubleday, it
is probable that the female aphis punctures the upper surface of a
leaf (more probably _leafstalk_), the result of the wound being the
growth of a hollow expansion in the vegetable tissue. Of this cavity
the creature takes possession and brings forth a progeny which lives
by puncturing the inner surface of their home, thus much increasing
the tendency to a morbid expansion of the soft growing tissue in an
outward direction. Meanwhile the neck of the sac-like gall thickens,
the aperture contracts and finally closes, imprisoning all the inmates.
Here they live and multiply until, as in the case of the pistacia
gall of Europe, the sac ruptures and allows of their escape. This, we
may imagine, takes place at the period when, after some generations
all wingless and perhaps all female (for the female aphis produces
for several generations without impregnation), a winged generation is
brought forth of both sexes. These may then fly to other spots, and
deposit eggs for a further propagation of their race.

The galls are collected when their green colour is changing into
yellow; they are then scalded.[689]

=Description=—The galls are light and hollow, varying in length from
1 to 2½ inches, and of extremely diverse and irregular form. The
simplest are somewhat egg-shaped, the smaller end being attached to the
leafstalk; but the form is rarely so regular, and more often the body
of the gall is distorted by numerous knobby or horn-like protuberances
or branches; or the gall consists of several lobes uniting in their
lower part and gradually attenuated to the point by which the
excrescence is attached to the leaf.[690] But though the form is thus
variable, the structure of these bodi4s is very characteristic. They
are striated towards the base, and completely covered on other parts
with a thick, velvety, grey down, which rubbed off on the prominences,
displays the reddish-brown colour of the shell itself. The latter is
⅒ to ¹/₂₀ of an inch in thickness, translucent and horny, but brittle
with a smooth and shining fracture. It is rather smoother on the inner
surface and of lighter colour than on the outer.

[687] _Pharm. Journ._ vii. (1848) 310.

[688] _Ibid._ x. (1851) 128.

[689] Stanisl. Julien et P. Champion, _Industries anc. et modernes de
l’Empire chinois_, 1869. 95.

[690] We have once met with galls imported from Shanghai which
differed from ordinary Chinese galls in not being horned, but all of
an elongated ovoid form, often pointed at the upper end, and having
moreover a strong _cheesy_ smell. They may be derived from _Distylium
racemosum_ S. et Z., though they do not perfectly accord with the
depressed pear-shaped forms figured by Siebold and Zuccarini (_Flora
Japonica_, tab. 94).

The galls when broken are generally found to contain a white,
downy-looking substance, together with the minute, dried-up bodies of
the killed insect.[691]

The drug as imported from Japan is usually a little smaller and paler;
it mostly fetches a better price in the market.

=Microscopic Structure=—The tissue of the galls is made up of
thin-walled, large cells irregularly traversed by small vascular
bundles and laticiferous vessels. The latter are mostly not branched.
The parenchyme is loaded with lumps of tannic matter and starch, the
latter having mostly lost by the treatment with boiling water its
granular appearance. The epidermis of the galls is covered with little
tapering hairs, consisting each of 1-5 cells, to which is due the
velvety down of the drug.

=Chemical Composition=—Chinese or Japanese galls contain about 70
per cent. of a tannic acid, which has been first shown by Stein in
1849 to be identical with that derived from oak galls (see Gallæ
halepenses), the so-called _gallo-tannic_ or common tannic acid.[692]
It is remarkable that this substance, which is by no means widely
distributed, is also present in _Rhus coriaria_, a species indigenous
in the Mediterranean region. Its leaves and shoots are the well-known
dyeing and tanning material _Sumach_.

Stein, however, pointed out at the same time, that in Chinese galls
gallo-tannic acid is accompanied by a small amount, about 4 per cent.,
of a different tannic matter.

=Commerce=—At present the supplies arrive chiefly from Hankow, from
which great trading city the export, in 1872, was no less than 30,949
peculs, equal to 36,844 cwt; 21,611 peculs, value 136,214 taels (one
tael about 6_s._) in 1874. In 1877 all China exported not more than
17,515 peculs. A little is also shipped from Canton and Ningpo.[693]
The quantity imported from China into the United Kingdom in 1872 was
8621 cwts., valued at £20,098. In the China trade returns, the drug
is always miscalled “Nut galls,” or “gallnuts.” Only those called
“Wu-pei-tze” are the galls under examination. There are also oak galls
exported from China resembling those from Western Asia. Japanese galls,
“Kifushi,” are shipped in increasing quantities at Hiogo.[694]

=Uses=—The galls under notice are employed, chiefly in Germany, for the
manufacture of tannic acid, gallic acid, and pyrogallol.

[691] See also Schenk, in Buchner’s _Repertorium für Pharm._ v. (1850)
26-27, or short abstract of that paper in the _Jahresbericht_ of
Wiggers, 1850. 48.

[692] See also Stenhouse, _Proceedings of the Royal Society_, xi.
(1862) 402.

[693] _Returns of Trade at the Treaty Ports of China_, for 1872. 154;
for 1874.

[694] Matsugata, _Le Japon à l’Exposition universelle_ (Paris, 1878)
116. 146.




LEGUMINOSÆ.


HERBA SCOPARII.

_Cacumina vel Summitates Scoparii_; _Broom Tops_; F. _Genêt à balais_;
G. _Besenginster_, _Pfriemenkraut_.

=Botanical Origin=—_Cytisus Scoparius_ Link (_Spartium Scoparium_ L.,
_Sarothamnus vulgaris_ Wimmer), the Common Broom, a woody shrub, 3 to 6
feet high, grows gregariously in sandy thickets and uncultivated places
throughout Great Britain, and Western and temperate Northern Europe. In
continental Europe it is plentiful in the valley of the Rhine up to the
Swiss frontier, in Southern Germany and in Silesia, but does not ascend
the Alps, and is absent from many parts of Central and Eastern Europe,
Polonia for instance. According to Ledebour, it is found in Central
and Southern Russia and on the eastern side of the Ural Mountains. In
Southern Europe its place is supplied by other species.

=History=—From the fact that this plant is chiefly a native of Western,
Northern and Central Europe, it is improbable that the classical
authors were acquainted with it; and for the same reason the remarks
of the early Italian writers may not always apply to the species under
notice. With this reservation, we may state that broom under the name
_Genista_, _Genesta_, or _Genestra_ is mentioned in the earliest
printed herbals, as that of Passau,[695] 1485, the _Hortus Sanitatis_,
1491, the _Great Herbal_ printed at Southwark in 1526, and others.
It is likewise the Genista as figured and described by the German
botanists and pharmacologists of the 16th century, like Brunfels,
Fuchs, Tragus, Valerius Cordus (“Genista angulosa”) and others. Broom
was used in ancient Anglo-Saxon medicine[696] as well as in the Welsh
“Meddygon Myddvai.” It had a place in the London Pharmacopœia of 1618,
and has been included in nearly every subsequent edition. Hieronymus
Brunschwyg gives[697] directions for distilling a water from the
flowers, “_flores genestæ_”—a medicine which Gerarde relates was used
by King Henry VIII. “against surfets and diseases thereof arising.”

Broom was the emblem of those of the Norman sovereigns of England
descended from Geoffrey the “Handsome,” or “_Plantagenet_” count of
Anjou (_obiit_ A.D. 1150), who was in the habit of wearing the common
broom of his country, the “_planta genista_,” in his helmet.

=Description=—The Common Broom has numerous straight ascending wiry
branches, sharply 5-angled and devoid of spines. The leaves, of which
the largest are barely an inch long, consist of 3 obovate leaflets on
a petiole of their own length. Towards the extremities of the twigs,
the leaves are much scattered and generally reduced to a single ovate
leaflet, nearly sessile. The leaves when young are clothed on both
sides with long reddish hairs; these under the microscope are seen each
to consist of a simple cylindrical thin-walled cell, the surface of
which is beset with numerous extremely small protuberances.

[695] _Herbarius, Patavie_ 1485.

[696] Cockayne _Leechdoms_, &c., iii. (1866) 316.

[697] _De arte distillandi_, first edition 1500, Argentorati, cap. xv.

The large, bright yellow, odorous flowers, which become brown in
drying, are mostly solitary in the axils of the leaves; they have a
persistent campanulate calyx divided into two lips minutely toothed,
and a long subulate style, curved round on itself. The legume is oblong
compressed, 1½ to 2 inches long by about ½ an inch wide, fringed with
hairs along the edge. It contains 10 to 12 olive-coloured albuminous
seeds, the funicle of which is expanded into a large fleshy strophiole.
They have a bitterish taste, and are devoid of starch.

The portion of the plant used in pharmacy is the younger herbaceous
branches, which are required both fresh and dried. In the former state
they emit when bruised a peculiar odour which is lost in drying. They
have a nauseous bitter taste.

=Chemical Composition=—Stenhouse[698] discovered in broom tops two
interesting principles, _Scoparin_, C₂₁H₂₂O₁₀, an indifferent or
somewhat acid body, and the alkaloid _Sparteine_, C₁₅H₂₆N₂, the first
soluble in water or spirit and crystallizing in yellowish tufts, the
second a colourless oily liquid heavier than water and sparingly
soluble in it, boiling at 288° C.

To obtain scoparin, a watery decoction of the plant is concentrated so
as to form a jelly after standing for a day or two. This is then washed
with a small quantity of cold water, dissolved in hot water and again
allowed to repose. By repeating this treatment with the addition of a
little hydrochloric acid, the chlorophyll may at length be separated
and the scoparin obtained as a gelatinous mass, which dries as an
amorphous, brittle, pale yellow, neutral substance, devoid of taste and
smell. Its solution in hot alcohol deposits it partly in crystals and
partly as jelly, which after drying are alike in composition. Hlasiwetz
showed (1866) that scoparin when melted with potash is resolved, like
kino or quercetin, into _Phloroglucin_, C₆H₆O₃, and _Protocatechuic
Acid_, 2 C₇H₆O₄.

The acid mother-liquors from which scoparin has been obtained when
concentrated and distilled with soda, yield besides ammonia a very
bitter oily liquid, _Sparteine_. To obtain it pure, it requires to be
repeatedly rectified, dried by chloride of calcium, and distilled in a
current of dry carbonic acid. It is colourless, but becomes brown by
exposure to light; it has at first an odour of aniline, but this is
altered by rectification. Sparteine has a decidedly alkaline reaction
and readily neutralises acids, forming crystallizable salts which are
extremely bitter. Conine, nicotine, and sparteine are the only volatile
alkaloids devoid of oxygen hitherto known to exist in the vegetable
kingdom.

Mills[699] extracted sparteine simply by acidulated water which he
concentrated and then distilled with soda. The distillate was then
saturated with hydrochloric acid, evaporated to dryness, and submitted
to distillation with potash. The oily sparteine thus obtained was dried
by prolonged heating with sodium in a current of hydrogen, and finally
rectified _per se_. Mills succeeded in replacing one or two equivalents
of the hydrogen of sparteine by one or two of C₂H₅ (ethyl). From 150
lb. the (dried?) plant, he obtained 22 cubic centimetres of sparteine,
which we may estimate as equivalent to about ½ per mille.

[698] _Phil. Trans._ 1851. 422-431.

[699] _Journ. of Chem. Soc._ xv. (1862) l.; Gmelin’s _Chem._ xvi.
(1864) 282.

Stenhouse ascertained that the amount of sparteine and scoparin depends
much on external conditions, broom grown in the shade yielding less
than that produced in open sunny places. He states that shepherds are
well aware of the shrub possessing narcotic properties, from having
observed their sheep to become stupified and excited when occasionally
compelled to eat it.

The experiments of Reinsch (1846) tend to show that broom contains
a bitter crystallizible principle in addition to the foregoing. The
seeds of the allied _Cytisus Laburnum L._ afford two highly poisonous
alkaloids, _Cytisine_ and _Laburnine_, discovered by A. Husemann and
Marmé in 1865.

=Uses=—A decoction of broom tops, made from the dried herb, is used as
a diuretic and purgative. The juice of the fresh plant, preserved by
the addition of alcohol, is also administered and is regarded as a very
efficient preparation.


SEMEN FŒNI GRÆCI.

_Semen Fœnugræci; Fenugreek_; F. _Semences de Fenugrec_; G.
_Bockshornsamen._

=Botanical Origin=—_Trigonella Fœnum græcum_ L., an erect,
sub-glabrous, annual plant, 1 to 2 feet high, with solitary,
subsessile, whitish flowers; indigenous to the countries surrounding
the Mediterranean, in which it has been long cultivated, and whence it
appears to have spread to India.

=History=—In the old Egyptian preparation _Kyphi_, an ingredient “Sebes
or Sebtu” is mentioned, which is thought by Ebers to mean fenugreek.
This plant was well known to the Roman writers on husbandry, as Porcius
Cato (B.C. 234-149) who calls it _Fœnum Græcum_ and directs it to be
sown as fodder for oxen. It is the τῇλις of Dioscorides and other Greek
writers. Its mucilaginous seeds, “siliquæ” of the Roman peasants, were
valued as an aliment and condiment for man, and as such are still
largely consumed in the East. They were likewise supposed to possess
many medicinal virtues, and had a place in the pharmacopœias of the
last century.

The cultivation of fenugreek in Central Europe was encouraged by
Charlemagne (A.D. 812), and the plant was grown in English gardens in
the 16th century.

=Description=—The fenugreek plant has a sickle-shaped pod, 3 to 4
inches long, containing 10 to 20 hard, brownish-yellow seeds, having
the smell and taste which is characteristic of peas and beans, with
addition of a cumarin-or melilot-flavour.

The seeds are about ⅛ of an inch long, with a rhomboid outline, often
shrivelled and distorted; they are somewhat compressed, with the hilum
on the sharper edge, and a deep furrow running from it and almost
dividing the seed into two unequal lobes. When the seed is macerated in
warm water, its structure becomes easily visible. The testa bursts by
the swelling of the internal membrane or endopleura, which like a thick
gelatinous sac encloses the cotyledons and their very large hooked
radicle.

=Microscopic Structure=—The most interesting structural peculiarity of
this seed arises from the fact that the mucilage with which it abounds
is not yielded by the cells of the epidermis, but by a loose tissue
closely surrounding the embryo.[700]

=Chemical Composition=—The cells of the testa contain tannin; the
cotyledons a yellow colouring matter, but no sugar. The air-dried
seeds give off 10 per cent. of water at 100° C., and on subsequent
incineration leave 7 per cent. of ash, of which nearly a fourth is
phosphoric acid.

Ether extracts from the pulverized seeds 6 per cent. of a fœtid, fatty
oil, having a bitter taste. Amylic alcohol removes in addition a small
quantity of resin. Alcohol added to a concentrated aqueous extract,
forms a precipitate of mucilage, amounting when dried to 28 per cent.
Burnt with soda-lime, the seeds yielded to Jahns[701] 3·4 per cent. of
nitrogen, equivalent to 22 per cent. of albumin. No researches have
been yet made to determine the nature of the odorous principle.

=Production and Commerce=—Fenugreek is cultivated in Morocco, in the
south of France near Montpellier, in a few places in Switzerland, in
Alsace, and in some other provinces of the German and Austrian empires,
as Thuringia and Moravia. It is produced on a far larger scale in
Egypt, where it is known by the Arabic name _Hulba_, and whence it is
exported to Europe and India. In 1873 it was stated that the profits
of the European growers were much reduced by the seed being largely
exported from Mogador and Bombay.

Under the Sanscrit name of _Methi_, which has passed, slightly
modified, into several of the modern Indian languages, fenugreek is
much grown in the plains of India during the cool season. In the year
1872-73, the quantity of seed exported from Sind to Bombay was 13,646
cwt., valued at £4,405.[702] From the port of Bombay there were shipped
in the same year 9,655 cwt., of which only 100 cwt. are reported as for
the United Kingdom.[703]

=Uses=—In Europe fenugreek as a medicine is obsolete, but the powdered
seeds are still often sold by chemists for veterinary pharmacy and as
an ingredient of curry powder. The chief consumption is, however, in
the so-called _Cattle Foods_.

The fresh plant in India is commonly eaten as a green vegetable, while
the seeds are extensively used by the natives in food and medicine.

[700] Figured by Lanessan in his French translation of the
_Pharmacographia_, i. (1878) 345.

[701] Experiments performed in my laboratory in 1867.—F. A. F.

[702] _Annual Statement of the Trade and Navigation of Sind_, for the
year 1872-73, printed at Karachi, 1873. p. 36.

[703] _Annual Statement_, etc., Bombay, 1873. 89.


TRAGACANTHA.

_Gummi Tragacantha_; _Tragacanth_, _Gum Tragacanth_; _F. Gomme
Adragante_; _G. Traganth_.

=Botanical Origin.=—Tragacanth is the gummy exudation from the
stem of several pieces of _Astragalus_, belonging to the subgenus
_Tragacantha_. The plants of this group are low perennial shrubs,
remarkable for their leaves having a strong, persistent, spiny petiole.
As the leaves and shoots are very numerous and regular, many of the
species have the singular aspect of thorny hemispherical cushions,
lying close on the ground; while others, which are those furnishing the
gum, grow erect with a naked woody stem, and somewhat resemble furze
bushes.

A few species occur in South-western Europe, others are found in Greece
and Turkey; but the largest number are inhabitants of the mountainous
regions of Asia Minor, Syria, Armenia, Kurdistan and Persia. The
tragacanth of commerce is produced in the last named countries, and
chiefly, though not exclusively, by the following species[704]:—

1. _Astragalus adscendens_ Boiss. et Hausskr., a shrub attaining 4
feet in height, native, of the mountains of South-western Persia at an
altitude of 9,000 to 10,000 feet. According to Haussknecht, it affords
an abundance of gum.

2. _A. leioclados_ Boiss.

3. _A. brachycalyx_ Fisch., a shrub of 3 feet high, growing on the
mountains of Persian Kurdistan, likewise affords tragacanth.

4. _A. gummifer_ Labill., a small shrub of wide distribution occurring
on the Lebanon and Mount Hermon in Syria, the Beryt Dagh in Cataonia,
the Arjish Dagh (Mount Argæus) near Kaisariyeh in Central Asia Minor,
and in Armenia and Northern Kurdistan.

5. _A. microcephalus_ Willd., like the preceding a widely distributed
species, extending from the south-west of Asia Minor to the north-east
coast, and to Turkish and Russian Armenia. A specimen of this
plant with incisions in the stem, was sent some years ago to the
Pharmaceutical Society by Mr. Maltass of Smyrna. We received a large
example of the same species, the stem of which is marked by old
incisions, from the Rev. W. A. Farnsworth of Kaisariyeh, who states
that tragacanth is collected from it on Mount Argæus.

6. _A. pycnocladus_ Boiss. et Haussk., nearly related to _A.
microcephalus_; it was discovered on the high mountains of Avroman and
Shahu in Persia by Professor Haussknecht, who states that it exudes
tragacanth in abundance.

7. _A. stromatodes_ Bunge, growing at an elevation of 5,000 feet on the
Akker Dagh range, near Marash in Northern Syria.

8. _A. kurdicus_ Boiss., a shrub 3 to 4 feet high, native of the
mountains of Cilicia and Cappadocia, extending thence to Kurdistan.
Haussknecht has informed us that from this and the last named species,
the so-called _Aintab Tragacanth_ is chiefly obtained.

[704] As described in Boissier’s _Flora Orientalis_, ii. (1872). We
have to thank Professor Haussknecht of Weimar for revising our list
of species, and for some valuable information as to the localities in
which the drug is produced.

Probably the drug is also to some extent collected from

9. _A. verus_ Olivier, in North-western Persia and Asia Minor.

Lastly as to Greece, tragacanth is also afforded by

10. _A. Parnassi_ Boiss., var. _cyllenea_, a small shrub found in
abundance on the northern mountains of the Morea, which is stated by
Heldreich[705] to be the almost exclusive source of the tragacanth
collected about Vostizza and Patras.

=History=—Tragacanth has been known from a very early period.
Theophrastus in the 3rd century B.C. mentioned Crete, the Peloponnesus
and Media as its native countries. Dioscorides, who as a native
of South-eastern Asia Minor was probably familiar with the plant,
describes it correctly as a low spiny bush. The drug is mentioned
by the Greek physicians Oribasius, Aëtius, and Paulus Ægineta (4th
to 7th cent.), and by many of the Arabian writers on medicine. The
abbreviated form of its name “Dragantum” already occurs in the book
“Artis veterinariæ, seu mulomedicinæ” of Vegetius Renatus, who lived
about A.D. 400. During the middle ages the gum was imported into Europe
through the trading cities of Italy, as shown in the statutes of
Pisa,[706] A.D. 1305, where it is mentioned as liable to impost.

Pierre Belon, the celebrated French naturalist and traveller, saw and
described, about 1550, the collecting of tragacanth in the northern
part of Asia Minor; and Tournefort in 1700 observed on Mount Ida in
Candia the singular manner in which the gum is exuded from the living
plant.[707]

=Secretion=—It has been shown by H. von Mohl[708] and by Wigand[709]
that tragacanth is produced by metamorphosis of the cell membrane, and
that it is not simply the dried juice of the plant.

The stem of a gum-bearing _Astragalus_ cut transversely, exhibits
concentric annual layers which are extremely tough and fibrous, easily
tearing lengthwise into thin filaments. These inclose a central column,
radiating from which are numerous medullary rays, both of very singular
structure, for instead of presenting a thin-walled parenchyme, they
appear to the naked eye as a hard translucent gum-like mass, becoming
gelatinous in water. Examined microscopically, this gummy substance is
seen to consist not of dried mucilage, but of the very cells of the
pith and medullary rays, in process of transformation into tragacanth.
The transformed cells, if their transformation has not advanced too
far, exhibit the angular form and close packing of parenchyme-cells,
but their walls are much incrassated and evidently consist of numerous
very thin strata.

That these cells are but ordinary parenchyme-cells in an altered state,
is proved by the pith and medullary rays of the smaller branches which
present no such unusual structure. Mohl was able to trace this change
from the period in which the original cell membrane could be still
easily distinguished from its incrusting layers, to that in which the
transformation had proceeded so far that it was impossible to perceive
any defined cells, the whole substance being metamorphosed into a more
or less uniform mucilaginous mass.

[705] _Nutzpflanzen Griechenlands_, Athen, 1862. 71.

[706] Bonaini, _Statuti inediti della città di Pissa dal xii. al xiv.
secolo_, iii. (1857) 106. 114.

[707] _Voyage into the Levant_, Lond. (1718) 43.

[708] _Botanische Zeitung_, 1857. 33; _Pharm. Journ._ xviii. (1859) 370.

[709] Pringsheim’s _Jahrbücher f. wissenchaftl. Botanik_, iii. (1861)
117.

The tension under which this peculiar tissue is held in the interior
of the stem is very remarkable in _Astragalus gummifer_ which one of
us had the opportunity of observing on the Lebanon in 1860.[710] On
cutting off a branch of the thickness of the finger, there immediately
exudes from the centre a stream of soft, solid tragacanth, pushing
itself out like a worm, to the length of ¾ of an inch, sometimes in the
course of half an hour; while much smaller streams (or none at all) are
emitted from the medullary rays of the thick bark.

=Production=—The principal localities in Asia Minor in which tragacanth
is collected are the district of Angora, the capital of the ancient
Galatia; Isbarta, Buldur and Yalavatz,[711] north of the gulf of
Adalia; the range of the Ali Dagh between Tarsous and Kaisariyeh, and
the mountainous country eastward as far as the valley of the Euphrates.
The drug is also gathered in Armenia on the elevated range of the
Bingol Dagh south of Erzerum; throughout Kurdistan from Mush for 500
miles in a south-eastern direction as far as the province of Luristan
in Persia, a region including the high lands south of lake Van, and
west of lake Urumiah. It is likewise produced in Persia farther
east, over an area 300 miles long by 100 to 150 miles broad, between
Gilpaigon and Kashan, southward to the Mahomed Senna range north-east
of Shiraz, thus including the lofty Bakhtiyari mountains.

As to the way in which the gum is obtained, it appears from the
statements of Maltass, that in July and August the peasants clear away
the earth from around the stem of the shrub, and then make in the bark
several incisions, from which during the following 3 or 4 days the gum
exudes and dries in flakes. In some localities they also puncture the
bark with the point of a knife. Whilst engaged in these operations,
they pick from the shrubs whatever gum they find exuded naturally.

Hamilton,[712] who saw the shrub in 1836 on the hills about Buldur,
says “the gum is obtained by making an incision in the stem near the
root, and cutting through the pith, when the sap exudes in a day or two
and hardens.”

Formerly the peasants were content to collect the naturally exuded
gum, no pains being taken to make incisions, whereby alone white flaky
gum is obtained. We have in fact heard an old druggist state, that he
remembered the first appearance of this fine kind of tragacanth in the
London market. According to Professor Haussknecht, whose observations
relate chiefly to Kurdistan and Persia, the tragacanth collected in
these regions is mostly a spontaneous exudation.

Tragacanth is brought to Smyrna, which is a principal market for it,
from the interior, in bags containing about 2 quintals each, by native
dealers who purchase it of the peasants. In this state it is a very
crude article, consisting of all the gatherings mixed together. To
fit it for the European markets, some of which have their special
requirements, it has to be sorted into different qualities, as _Flaky
or Leaf Gum, Vermicelli_ and _Common_ or _Sorts_; this sorting is
performed almost exclusively by Spanish Jews.

[710] Hanbury, _Science Papers_, 29.

[711] _Pharm. Journ._ xv. (1856) 18.

[712] _Researches in Asia Minor, Pontus and Armenia_, i. (1842) 492.

=Description=—The peculiar conditions under which tragacanth exudes,
arising from the pressure of the surrounding tissues and the power of
solidifying a large amount of water, will account to some extent for
the strange forms in which this exudation occurs.

The spontaneously exuded gum is mostly in mammiform or botryoidal
masses from the size of a pea upwards, of a dull waxy lustre, and
brownish or yellowish hue. It also occurs in vermiform pieces more or
less contorted and very variable in thickness; some of them may have
exuded as the result of artificial punctures. It is this form that
bears the trade name of _Vermicelli_. The most valued sort is however
the _Flake Tragacanth_, which consists of thin flattish pieces or
flakes, 1, 2, 3 or more inches in length, by ¼ to 1 in width.[713]
They are marked on the surface by wavy lines and bands, or by a series
of concentric wave-marks, as if the soft gum had been forced out by
successive efforts. The pieces are contorted and altogether very
variable in form and size. The gum is valued in proportion to its
purity and whiteness. The best, whether vermiform or flaky, is dull
white, translucent, devoid of lustre, somewhat flexible and horny,
firm, and not easily broken, inodorous and with scarcely any or only a
slight bitterish taste.

The tragacanth of Kurdistan and Persia shipped from Bagdad, which
sometimes appears in the London drug sales under the incorrect name of
_Syrian Tragacanth_, is in very fine and large pieces which are rather
more translucent and ribbon-like than the selected tragacanth imported
from Smyrna: in fact, the two varieties when seen in bulk are easily
distinguishable.

The inferior kinds of tragacanth have more or less of colour, and are
contaminated with bark, earth and other foreign substances. They used
formerly to be much imported into Europe, and were frequently mentioned
during the past centuries as _black tragacanth_.

=Microscopic Structure=—The transformation of the cells into tragacanth
is usually not so complete, that every trace of the original tissue
or its contents has disappeared. In the ordinary drug, the remains
of cell-walls as well as starch granules may be seen, especially if
thin slices are examined under oil or any other liquid not acting on
the gum. Polarized light will then distinctly show the starch and the
cell-walls. If a thin section is imbued with a solution of iodine in
iodide of potassium and then moistened with concentrated sulphuric
acid, the cell-walls will assume a blue colour as well as the starch.

[713] In the Museum of the Pharmaceutical Society in London, there is
some Flake Tragacanth remarkable for its enormous size, but in other
respects precisely like the ordinary kind. The ribbon-like strips are
as much as 2 inches wide and ³/₁₀ of an inch thick, and the largest
which is several inches long weighs 2¾ ounces. Professor Haussknecht
has informed us that he has seen in Luristan stems of _Astragalus
eriostylus_ Boiss. et Haussk. more than 6 feet in height and 5 inches
in diameter, and bearing tragacanth. It is probable that the specimen
of gum we have described was produced by some species attaining these
extraordinary dimensions. Among the Kurdistan tragacanth, there occur
curious cylindrical vermiform pieces, about ⅕ of an inch in diameter,
coated with a network of woody fibre. We are told by Professor H. that
they are picked out of the centre of cut off pieces of stem, split open
by rapid drying in the sun.

=Chemical Composition=—When tragacanth is immersed in water it swells,
and in the course of some hours disintegrates so that it can be
diffused through the liquid. So great is its power of absorbing water
that even with 50 times its weight, it forms a thick mucilage. If one
part of tragacanth is shaken with 100 parts of water and the liquid
filtered, a neutral solution may be obtained which yields an abundant
precipitate with acetate of lead, and mixes clearly with a concentrated
solution of ferric chloride or of borax,—in these respects differing
from a solution of gum arabic. On the other hand, it agrees with the
latter in that it is thrown down as a transparent jelly by alcohol,
and rendered turbid by oxalate of ammonium. The residue on the filter
is a slightly turbid, slimy, non-adhesive mucilage, which when dried
forms a very coherent mass. It has received the name of _Bassorin_,
_Traganthin_ or _Adraganthin_, and agrees with the formula C₁₂H₂₀O₁₀.

Tragacanth is readily soluble in alkaline liquids, even in ammonia
water and at the same time assumes a yellow colour; heated with ammonia
in a sealed tube at 90° C. it blackens.

The drug loses by drying about 14 per cent. of water, which it absorbs
again on exposure to the air. Pure flake tragacanth incinerated leaves
3 per cent. of ash.

=Commerce=—Tragacanth is shipped from Constantinople, Smyrna and
the Persian Gulf. The annual export of the gum from Smyrna has been
recently stated[714] to be 4,500 quintals, value 675,000 Austrian
florins (£67,500); and the demand to be always increasing.

=Uses=—Though tragacanth is devoid of active properties, it is a very
useful addition to many medicines. Diffused in water it acts as a
demulcent, and is also convenient for the suspension of a heavy powder
in a mixture. It is an important ingredient for imparting firmness to
lozenges and pill-masses.

=Adulteration=—The fine quantities consisting of large distinct pieces
are not liable to adulteration, but the small and the inferior kinds
are often sophisticated. At Smyrna, tragacanth is mixed with gums
termed respectively _Mosul_ and _Caramania Gum_. The former appears
to be simply very inferior tragacanth; the latter which is sometimes
called in the London market _Hog Gum Tragacanth_ or _Bassora Gum_,[715]
is said to be the exudation of almond and plum trees. It occurs in
nodular masses of a waxy lustre and dull brown hue, which immersed in
water gradually swells into a voluminous white mass. To render this gum
available for adulteration, the lumps are broken into small angular
fragments, the size of which is adjusted to the sort of tragacanth with
which they are to be mixed. As the Caramania Gum is somewhat dark,
it is usual to whiten it by _white lead_, previous to mixing it with
_Small Leaf_ or _Flake_, or with the _Vermicelli_ gum.

By careful examination the fraud is easily detected, angular fragments
not being proper to any true tragacanth. The presence of lead may be
readily proved by shaking suspected fragments for a moment with dilute
nitric acid, which will dissolve any carbonate present, and afford a
solution which may be tested by the ordinary reagents.

[714] C. von Scherzer, _Smyrna_, Wien, 1873. 143.

[715] It is sometimes shipped from Bussorah.


RADIX GLYCYRRHIZÆ.

_Radix Liquiritiæ_; _Liquorice Root_; F. _Réglisse_; G. _Süssholz_,
_Lakritzwurzel_.

=Botanical Origin=—_Glycyrrhiza glabra_ L., a plant which under several
well marked varieties[716] is found over an immense extent of the
warmer regions of Europe, spreading thence eastward into Central Asia.
The root used in medicine is derived from two principal Varieties,
namely:—

α. _typica_—Nearly glabrous, leaves glutinous beneath, divisions of
the calyx linear-lanceolate often a little longer than the tube,
corolla purplish blue, legume glabrous, 3-6 seeded. It is indigenous to
Portugal, Spain, Southern Italy, Sicily, Greece, Crimea, the Caucasian
Provinces and Northern Persia; and is cultivated in England, France and
Germany.

γ. _glandulifera_ (_G. glandulifera_ W.K.)—Stems more or less pubescent
or roughly glandular, leaves often glandular beneath, legume sparsely
or densely echinate-glandular, many-seeded, or short and 2-3 seeded. It
occurs in Hungary, Galicia, Central and Southern Russia, Crimea, Asia
Minor, Armenia, Siberia, Persia, Turkestan and Afghanistan.

_G. glabra_ L. has long, stout, perennial roots, and erect, herbaceous
annual stems. In var. α., the plant throws out long stolons which run
horizontally at some distance below the surface of the ground.

=History=—Theophrastus[717] in commenting on the taste of different
roots (3rd cent. B.C.) instances the sweet Scythian root which grows
in the neighbourhood of the lake Mæotis (Sea of Azov), and is good for
asthma, dry cough and all pectoral diseases,—an allusion unquestionably
to liquorice. Dioscorides,[718] who calls the plant γλυκιῤρίζη, notices
its glutinous leaves and purplish flowers, but as he describes the
pods to be in balls resembling those of the plane, and the roots to be
sub-austere (ὑπόστρυϕνοι) as well as sweet, it is possible he had in
view _Glycyrrhiza echinata_ L. as well as _G. glabra_.

Roman writers, as Celsus and Scribonius Largus, mention liquorice as
_Radix dulcis_. Pliny, who describes it as a native of Cilicia and
Pontus, makes no allusion to it growing in Italy.

The cultivation of liquorice in Europe does not date from a very remote
period, as we conclude from the absence of the name in early mediæval
lists of plants. It is, for instance, not enumerated among the plants
which Charlemagne ordered (A.D. 812) to be introduced from Italy into
Central Europe;[719] nor among the herbs of the convent gardens as
described by Walafridus Strabus,[720] abbot of Reichenau, lake of
Constance, in the 9th century; nor yet in the copious list of herbs
contained in the vocabulary of Alfric, archbishop of Canterbury in the
10th century.[721]

[716] We accept those adopted by Boissier in his _Flora Orientalis_,
ii. (1872) 202.

[717] _Hist. Plant._ lib. ix. c. 13.

[718] Lib. iii. c. 5.

[719] Pertz, _Monumenta Germaniæ historica, Legum_, i. (1835) 186.

[720] Migne, _Patrologiæ Cursus_, cxiv. 1122.

[721] Wright, _Volume of Vocabularies_, 1857. 30. This work contains
several other early lists of plants.

On the other hand, liquorice is described as being cultivated in Italy
by Piero de’ Crescenzi[722] of Bologna, who lived in the 13th century.
The cultivation of the plant in the north of England existed at the
close of the 16th century, but how much earlier we have not been able
to trace.

As a medicine the drug was well known in Germany in the 11th century,
and an extensive cultivation of the plant was carried on near Bamberg,
Bavaria, in the 16th century, so that in many of the numerous
pharmaceutical tariffs of those times in Germany not only Glycyrrhizæ
succus creticus, seu candiacus, seu venetus is quoted, but also
expressly that of Bamberg.[723]

The word _Liquiritia_, whence is derived the English name _Liquorice_
(_Lycorys_ in the 13th century), is a corruption of _Glycyrrhiza_, as
shown in the transitional mediæval form _Gliquiricia_. The Italian
_Regolizia_, the German _Lacrisse_ or _Lakriz_, the Welsh _Lacris_[724]
and the French _Réglisse_ (anciently _Requelice_ or _Recolice_) have
the same origin.

=Cultivation, and habit of growth=—The liquorice plant is cultivated in
England at Mitcham and in Yorkshire, but not on a very extensive scale.
The plants, which require a good deep soil, well enriched by manure,
are set in rows, attain a height of 4 to 5 feet and produce flowers
but not seeds. The root is dug up at the beginning of winter, when
the plant is at least 3 or 4 years old. The latter has then a crown
dividing into several aerial stems. Below the crown is a principal root
about 6 inches in length, which divides into several (3 to 5) rather
straight roots, running without much branching, though beset with
slender wiry rootlets, to a depth of 3, 4 or more feet.[725] Besides
these downward-running roots, the principal roots emit horizontal
runners or stolons, which grow at some distance below the surface and
attain a length of many feet. These runners are furnished with leaf
buds and throw up stems in their second year.

Every portion of the subterraneous part of the plant is carefully
saved; the roots proper are washed, trimmed, and assorted, and either
sold fresh in their entire state, or cut into short lengths and dried,
the cortical layer being sometimes first scraped off. The older
runners distinguished at Mitcham as “_hard_,” are sorted out and sold
separately; the young, called “_soft_,” are reserved for propagation.

In Calabria, the singular practice prevails of growing the liquorice
among the wheat in the cornfields.

=Description=—Fresh liquorice (English) when washed is externally of a
bright yellowish-brown. It is very flexible, easily cut with a knife,
exhibiting a light yellow, juicy, internal substance which consists
of a thick bark surrounding a woody column. Both bark and wood are
extremely tough, readily tearing into long, fibrous strips. The root
has a peculiar earthy odour, and a strong and characteristic sweet
taste.

[722] _Libro della Agricoltura_, Venet. 1511. lib. vi. c. 62.

[723] Gesner, _Valerii Cordi Hist. stirp._ Argentorati, 1561.
164.—Flückiger, _Documente zur Geschichte der Pharmacie_, Halle, 1876.
39. 46.

[724] In the “Meddygon Myddvai” of the 13th century, Llandovery, 1861,
p. 159. 355 (it is written there Licras).

[725] This form of root, which reminds one of a whip with three or
four lashes and a very short handle, is probably due to the method of
propagating adopted at Mitcham, where a short stick or _runner_ is
planted upright in the ground.

Dried liquorice root is supplied in commerce either with or without
the thin brown coat In the latter state it is known as _peeled_ or
_decorticated_. The English root, of which the supply is very limited,
is usually offered cut into pieces 3 or 4 inches long, and of the
thickness of the little finger.

_Spanish Liquorice Root_, also known as _Tortosa_ or _Alicante
Liquorice_, is imported in bundles several feet in length, consisting
of straight unpeeled roots and runners, varying in thickness from ¼ to
1 inch. The root is tolerably smooth or somewhat transversely cracked
and longitudinally wrinkled; that from Tortosa is usually of a good
external appearance, that from Alicante sometimes untrimmed, dirty, of
very unequal size, showing frequently the knobby crowns of the root.
Alicante liquorice root is sometimes shipped in bags or loose.

_Russian Liquorice Root_, which is much used in England, is we presume
derived from _G. glabra_ var. _glandulifera_. It is imported from
Hamburg in large bales, and is met with both peeled and unpeeled. The
pieces are 12 to 18 inches long, with a diameter of ¼ of an inch to 1
or even 2 inches. Sometimes very old roots, split down the centre and
forming channelled pieces as much as 3½ inches wide at the crown end,
are to be met with. This liquorice in addition to being sweet has a
certain amount of bitterness.

=Microscopic Structure=—The root exhibits well-marked structural
peculiarities. The corky layer is made up of the usual tabular cells;
the primary cortical tissue of a few rows of cells. The chief portion
of the bark consists of liber or endophlœum, and is built up for the
most part of parenchymatous tissue accompanied by elongated fibres of
two kinds, partly united into true liber-bundles and partly forming a
kind of network, the smaller threads of which deviate considerably from
the straight line. Solution of iodine imparts an orange hue to both
kinds of bast-bundles, and well displays the structural features of the
bark.

The woody column of the root exhibits three distinct forms of cell,
namely ligneous cells (libriform) with oblique ends; parenchymatous,
almost cubic cells; and large pitted vessels. In the Russian root, the
size of all the cells is much more considerable than in the Spanish.

=Chemical Composition=—The root of liquorice contains, in addition
to sugar and albuminous matter, a peculiar sweet substance named
_Glycyrrhizin_, which is precipitated from a strong decoction upon
addition of an acid or solution of cream of tartar, or neutral or basic
acetate of lead. When washed with dilute alcohol and dried, it is an
amorphous yellow powder, having a strong bitter-sweet taste and an
acid reaction. It forms with hot water a solution which gelatinizes
on cooling, does not reduce alkaline tartrate of copper, is not
fermentable, and does not rotate the plane of polarization. From the
analysis and experiments of Rösch, performed in the laboratory of
Gorup-Besanez at Erlangen, in 1876, the formula C₁₆H₂₄O₆ was derived
for glycyrrhizin. By boiling it with dilute hydrochloric or sulphuric
acid it is resolved into a resinous amorphous bitter substance named
_Glycyrretin_, and an uncrystallizable sugar having the characters of
glucose. The formula of glycyrretin has not yet been settled. Weselsky
and Benedikt, in 1876, showed that 65 per cent. of it may be obtained
from glycyrrhizin. By melting glycyrretin with about 5 parts of caustic
potash paraoxy-benzoïc acid is produced.

Alkalis easily dissolve glycyrrhizin with a brown colour and emission
of a peculiar odour. In the root it perhaps exists combined with
ammonia, inasmuch as the aqueous extract evolves that alkali when
warmed with potash (Roussin, 1875). According to Sestini (1878)
glycyrrhizin is present in the root combined with calcium; he obtained
6·3 per cent. of glycyrrhizin from the root previously dried at 110°.
By exhausting glycyrrhizin with glacial acetic acid Habermann in 1876
succeeded in isolating almost _colourless_ crystals having the sweet
taste of the root. They yield, by boiling them with dilute acids, a
yellow substance which would appear to agree with glycyrretin. The deep
yellow walls of the vessels and prosenchymatous cells appear to be the
chief seat of the glycyrrhizin.

The sugar of liquorice root has not yet been isolated; the aqueous
infusion of the _dried_ root separates protoxide of copper from an
alkaline solution of cupric tartrate. Yet the sugar as extracted from
the _fresh_ root by cold water does not precipitate alkaline cupric
tartrate at all in the cold, and not abundantly even on prolonged
boiling.

_Asparagin_ was obtained from the root by Robiquet (1809) and by
Plisson (1827). Sestini (1878) isolated 2-4 parts of asparagin from
100 parts of the root dried at 110° C. Robiquet also found the root to
contain malic acid. The presence of starch in abundance is shown by the
microscope as well as by testing a decoction of the root with iodine.
The outer bark of the root contains a small quantity of tannin.

=Commerce=—Liquorice root is imported into Great Britain from Germany,
Russia and Spain, but there are no data for showing to what extent.
France imported in 1872 no less than 4,348,789 kilogrammes (4282 tons),
which was more than double the quantity imported the previous year.[726]

Liquorice root is much used in China, and is largely produced in some
of the northern provinces. In 1870, 1,304 peculs were shipped from
Ningpo,[727] and 7,147 pepuls in 1877 from Cheefu (one pecul = 133·33
lb. avdp.).

=Uses=—Liquorice root is employed for making extract of liquorice and
in some other pharmaceutical preparations. The powdered root is used to
impart stiffness to pill-masses and to prevent the adhesion of pills.
Liquorice has a remarkable power of covering the flavour of nauseous
medicines. As a domestic medicine, liquorice root is far more largely
used on the Continent than in Great Britain.

[726] _Documents statistiques réunis par l’administration des Douanes
sur le commerce de la France_, année 1872, Paris, 1873.

[727] _Reports on Trade at the Treaty Ports in China for_ 1870,
Shanghai, 1871. 13. 62.


SUCCUS GLYCYRRHIZÆ.

    _Succus Liquiritiæ_, _Extractum Glycyrrhizæ
        Italicum_; _Italian Extract of Liquorice_,
        _Spanish Liquorice_, _Spanish Juice_;
        F. _Jus ou Suc de Réglisse_; G.
        _Süssholzsaft_, _Lakriz_.

=Botanical Origin=—_Glycyrrhiza glabra_ L., see preceding article, p.
179.

=History=—Inspissated liquorice juice was known in the time of
Dioscorides, and may be traced in the writings of Oribasius and
Marcellus Empiricus in the latter half of the 4th century, and in those
of Paulus Ægineta in the 7th. It appears to have been in common use in
Europe during the middle ages. In A.D. 1264, “_Liquorice_” is charged
in the Wardrobe Accounts of Henry III.;[728] and as the article cost
3_d_. per lb., or the same price as grains of paradise and one-third
that of cinnamon, we are warranted in supposing the _extract_ and not
the mere _root_ is intended. Again, in the Patent of Pontage granted by
Edward I., A.D. 1305, to aid in repairing the London Bridge, permission
is given to lay toll on various foreign commodities including
_Liquorice_.[729] A political song written in 1436[730] makes mention
of _Liquorice_ as a production of Spain, but the plant is not named as
an object of cultivation by Herrera, the author of a work on Spanish
agriculture in 1513.

Saladinus,[731] who wrote about the middle of the 15th century,
names it among the wares kept by the Italian apothecaries; and it is
enumerated in a list of drugs of the city of Frankfort written about
the year 1450.[732]

Dorsten,[733] in the first half of the 16th century, mentions the
liquorice plant as abundant in many parts of Italy, and describes the
method of making the _Succus_ by crushing and boiling the fresh root.
Mattioli[734] states that the juice made into _pastilli_ was brought
every year from Apulia, and especially from the neighbourhood of Monte
Gargano. Extract of liquorice was made at Bamberg in Germany, where the
plant is still largely cultivated, as early as 1560.[735]

=Manufacture=—This is conducted on a large scale in Spain, Southern
France, Sicily, Calabria, Austria, Southern Russia (Astracan and
Kasan), Greece (Patras) and Asia Minor (Sokia and Nazli, near Smyrna);
but the extract with which England is supplied is almost exclusively
the produce of Calabria, Sicily and Spain.

The process of manufacture varies only by reason of the amount of
intelligence with which it is performed, and the greater or less
perfection of the apparatus employed. As witnessed by one of us (H.)
at Rossano in Calabria in May, 1872, it may be thus described from
notes made at the time. The factory employs about 60 persons, male
and female. The root having been taken from the ground the previous
winter, is stacked in the yard around the factory; it is mostly of the
thickness of the fingers, with here and there a piece of larger size up
to a diameter of nearly 2 inches; some of it sprouting.

[728] Rogers, _Hist. of Agriculture and Prices_, ii. (1866) 543.

[729] _Chronicles of London Bridge_, 1827. 155.

[730] Wright, _Political Poems and Songs_ (Master of the Rolls series),
ii. (1861) 160.

[731] _Compendium Aromatariorum_, Bonon. 1488.

[732] Flückiger, _Die Frankfurter Liste_, Halle, 1873, page 10, No. 204.

[733] _Botanicon_, Francof. 1540. 175.

[734] _Comm. in lib. Diosc._, Basil. 1574. 485.

[735] Gesner, _Horti Germanici_, Argent. 1561. 257, b.

As required, the root is taken within the building and crushed under
a heavy millstone to a pulp, water-power being employed. It is then
transferred to boilers and boiled with water over a naked fire. The
decoction is run off and the residual root pressed in circular bags
like those used in the olive-mills. The liquor which is received into
cisterns below the floor is then pumped up into copper pans, in which
the evaporation is conducted also over the naked fire—even to the
very last, care being taken by constant stirring to avoid burning the
extract. The extract or _pasta_ is removed from the pan while warm, and
taken in small quantities to an adjoining apartment where a number of
women are employed in rolling it into sticks. It is first weighed into
portions, each of which the woman seated at the end of a long table
tears with her hand into about a dozen pieces. These are passed to the
women sitting next who roll them with their hands into cylindrical
sticks, the table on which the rolling is done being of wood, and the
_pasta_ moistened with oil to prevent its adhesion to the hands. Near
the further end of the table are some frames made of marble or metal,
clean and bright, so arranged as to bring the sticks when rolled in
them to the proper length and thickness. When thus adjusted, they are
carefully ranged on a board, and a woman then stamps them with the name
of the manufacturer. Lastly the sticks laid on boards are stacked up in
a room to dry.

In some establishments the vacuum-pan has been introduced for the
inspissation of the decoction. At the great manufactory of Mr. A. O.
Clarke at Sokia near Smyrna, all the processes are performed by steam
power.

=Description=—Liquorice juice of good quality is met with in
cylindrical sticks stamped at one end with the maker’s name or mark.
They are of various sizes, but generally not larger than 6 to 7 inches
long by about an inch in diameter. They are black, when new or warm
slightly flexible, but breaking when struck, and then displaying a
sharp-edged fracture, and shining conchoidal surface on which a few air
bubbles are perceptible; thin splinters are translucent. The extract
has a special odour and dissolves in the mouth with a peculiar strong
sweet taste. By complete drying, it loses from 11 to 17 per cent. of
water.

Several varieties of Stick Liquorice are met with in English commerce,
and command widely different prices. The most famous is the _Solazzi
Juice_, manufactured at Corigliano, a small town of Calabria in the
gulf of Taranto, at an establishment belonging to the sons of Don
Onorato Gaetani, duke of Laurenzano and prince of Piedimonte d’Alife,
who inherited the manufacture from his father-in-law, the Cavaliere
Domenico Solazzi Castriota. The Solazzi Juice destined for the English
market is usually shipped at Naples; it has for many years been wholly
consigned to two firms in London, and in quantity not always equal
to the demand. Of the other varieties we may mention _Barracco_,
manufactured at the establishment of Messieurs Barracco at Cotrone on
the eastern coast of Calabria; _Corigliano_, produced at a factory
at Corigliano, belonging to Baron Compagna. The sticks stamped
_Pignatelli_ are from the works of Vincenzo Pignatelli, prince of
Strongoli, at Torre Cerchiora, where 300 to 400 workmen are employed.

The juice is also imported in a block form, having while warm and soft
been allowed to run into the wooden case in which it is exported.
This juice, which is known as _Liquorice Paste_, is largely imported
from Spain and Asia Minor, but on account of a certain bitterness is
unsuited for use as a sweetmeat.

=Chemical Composition=—Hard extract of liquorice, such as that just
described, is essentially different in composition and properties from
the Extract of Liquorice (_Extractum Glycyrrhizæ_) of the _British
Pharmacopœia_.[736] The latter is a soft, hygroscopic substance,
entirely soluble in cold water, whereas the so-called _Spanish Juice_
when treated with cold water leaves a large residue undissolved.

It has been sometimes supposed that the presence of this residue
indicates adulteration, but such is far from being the fact, as was
conclusively shown by the researches of a French Commission appointed
to investigate the process recommended by Delondre.[737] This
commission subjected liquorice root to the successive action of cold
water, boiling water, and lastly of steam. By the first menstruum 15
per cent., and by the second an additional 7½ per cent., were obtained
of a hygroscopic extract much more soluble than commercial liquorice,
and totally unsuitable for being moulded into sticks. The residue
having been then exhausted by steam, 16 per cent. was obtained of an
extract differing entirely from those of the previous operations.
It was a dry friable substance, cracking and falling to pieces in
the drying stove, having a sweet taste without acridity, not readily
dissolving in the mouth, and very imperfectly soluble in cold water.
This then was the substance required to give firmness to the more
soluble matter, and to render possible the preparation of an extract
possessing that degree of solubility and hardness which would render it
an agreeable sweetmeat, as well as a permanent and stable commodity. In
fact, by treating the root at once with steam according to Delondre’s
process, the experimenters obtained 42 to 45 per cent. of extract
having all the qualities desired in good Italian or Spanish Juice.

When the latter substance is suspended in water undisturbed, the
soluble matter may be dissolved out, the stick still retaining its
original form. Glycyrrhizin, which is but slightly soluble in cold
water, remains to some extent in the residue, and by an alkaline
solution may be afterwards extracted together with colouring matter and
probably also pectin. The proportion of soluble matter which the best
varieties of liquorice juice yield to cold water varies from about 60
to 70 per cent. A sample of Solazzi Juice recently examined by one of
us, lost 8·4 per cent. when dried at 100° C.; it was then exhausted
by 60 times its weight of cold water used in successive quantities,
by which means 66·8 per cent. of soluble matter were removed. The
residue consisted of minute starch granules, fragments of the root, and
colouring matter partially soluble in ammonia. Small shreds of copper
were also visible to the naked eye. The dried juice yielded 6·3 per
cent. of ash.

[736] Made by treating the crushed root with cold water.

[737] _Journ. de Pharm._ xxx. (1856) 428; an abstract by Redwood in
_Pharm. Journ._ xvi. (1857) 403.

Corigliano liquorice treated in the same manner gave 71·2 per cent. of
extract soluble in cold water; Barracco liquorice 64·9.

The small liquorice lozenges known as _Pontefract Cakes_ (Dunhill’s),
not previously dried, gave 71 per cent. of matter soluble in cold water.

=Commerce=—The value of the imports of Liquorice into the United
Kingdom has been for the last five years as follows:—

      1868      1869       1870       1871       1872
    £89,482   £83,832    £70,165    £55,129    £75,991

The last named sum represents a quantity of 28,000 cwt., of which
11,170 cwt. were furnished by Italy, and the remainder by Turkey,
France, Spain and other countries.

The total exports of Liquorice Paste from Smyrna were estimated in 1872
as 1,200 to 1,400 tons (24,000 to 28,000 cwt.) per annum.

=Uses=—Stick liquorice is sucked as a remedy for coughs, and by
children as a sweetmeat. It is also used in lozenges, and in some
pharmacopœias is admitted as the raw material from which to prepare
soft extract of liquorice.

The block liquorice, of which a large quantity is imported, is chiefly
used in the manufacture of tobacco for smoking and chewing.


OLEUM ARACHIS.

_Ground-nut oil_, _Earth-nut oil_, _Pea-nut oil_, _Arachis oil_; F.
_Huile d’Arachide ou de Pistache de terre_; G. _Erdnussöl_.

=Botanical Origin=—_Arachis hypogæa_ L., a diffuse herbaceous annual
plant, having stems a foot or two long, and solitary axillary flowers
with an extremely long filiform calyx-tube. After the flower withers,
the torus supporting the ovary becomes elongated as a rigid stalk,
which bends down to the ground and forces into it the young pod, which
matures its seeds some inches below the surface. The ripe pod is
oblong, cylindrical, about an inch in length, indehiscent, reticulated,
and contains one or two, or exceptionally even four irregularly ovoid
seeds.

The plant is cultivated for the sake of its nutritious oily seeds in
all tropical and subtropical countries, but especially on the west
coast of Africa. It is unknown in the wild state. De Candolle[738]
regards it as a native of Brazil, to which region the other species
of the genus exclusively belong. But the opinion of one of us[739]
is strongly in favour of the plant being indigenous to Tropical
Africa, and so is that also of Schweinfurth. Arachis is one of the
most universally cultivated plants throughout Tropical Africa, from
Senegambia to lake Tanganyika. In Europe it has not proved remunerative.

[738] _Géographie Botanique_, ii. (1855) 963.

[739] Flückiger, _Ueber die Erdnuss—Archiv der Pharmacie_, 190. (1869)
70-84, with figure.

=History=—The first writer to notice Ground-Nut appears to be
Fernandez de Oviedo y Valdes, who lived in Hayti from A.D. 1513 to
1525; he mentions in his _Cronica de las Indias_[740] that the Indians
cultivated very much the fruit _Mani_, a name still used for Arachis
in Cuba and in South America. A little later, Monardes,[741] described
a nameless subterraneous fruit, found about the river Maranon and
held in great esteem by both Indians and Spaniards. But before, the
French colonists sent in 1555 by Admiral Coligny to the Brazilian coast
had become acquainted with the “Mandobi,” which Jean de Léry[742]
described quite unmistakably. Good accounts and figures of it were
given in the following century by Johannes de Laet (1625),[743] and
by Marcgraf,[744] who calls it by its Brazilian name of _Mundubi_. It
is enumerated by Stisser among the rare plants cultivated by him at
Helmstedt (Brunswick), about the year 1697.[745]

It is only in very recent times that the value of the Ground-Nut has
been recognized in Europe. Jaubert, a French colonist at Gorée near
Cape Verde, first suggested about 1840 its importation as an oil-seed
into Marseilles, where it now constitutes one of the most important
articles of trade.[746]

=Description=—The fat oil of _Arachis_, as obtained by pressure without
heat, is almost colourless, of an agreeable faint odour and a bland
taste resembling that of olive oil. An inferior oil is obtained by
warming the seeds before pressing them. The best oil has a sp. gr. of
about 0·918; it becomes turbid at 3° C., concretes at -3° to -4°, and
hardens at -7°. On exposure to air it is but slowly altered, being one
of the non-drying oils. At length it thickens considerably, and assumes
even in closed vessels a disagreeable rancid smell and taste.

=Chemical Composition=—The oil consists of the glycerides of four
different fatty acids. The common _Oleic Acid_, C₁₈H₃₄O₂, that is to
say its glycerin compound, is the chief constituent of Arachis oil.
_Hypogæic Acid_, C₁₆H₃₀O₂, has been pointed out by Gössmann and Scheven
(1854) as a new acid, whereas it is thought by other chemists to agree
with one of the fatty acids obtained from whale oil. The melting point
of this acid from Arachis oil is 34-35° C. The third acid afforded by
the oil is ordinary _Palmitic Acid_, C₁₆H₃₂O₂, with a fusing point of
62° C. _Arachic Acid_, C₂₀H₄₀O₂, the fourth constituent, has also been
met with among the fatty acids of butter and olive oil, and, according
to Oudemans (1866), in the tallow of _Nephelium lappaceum_ L., an
Indian plant of the order _Sapindaceæ_.

When ground-nut oil is treated with hyponitric acid, which may be most
conveniently evolved by heating nitric acid with a little starch, a
solid mass is obtained, which yields by crystallization from alcohol
_Elaïdic_ and _Gæidinic_ acids, the former isomeric with oleic, the
latter with hypogæic acid.

=Production and Commerce=—The pods are exported on an immense and ever
increasing scale from the West Coast of Africa. From this region,
not less than 66 millions of kilogrammes, value 26 millions of
francs (£1,040,000), were imported in 1867, almost exclusively into
Marseilles. From the French possessions on the Senegal, 24 millions of
kilogr. were exported in 1876.

[740] Lib. vii. cap. 5. Fol. 1074 f. (1547), as quoted by C. Ph. von
Martius in _Gelehrte Anzeigen der bayerischen Akademie_, 1839. 969.

[741] _Las Cosas que se traen de nuestras Indias Occidentales_,
Sevilla, 1569, part 2.

[742] _Histoire d’un voyage faict en la Terre du Bresil, autrement dite
Amérique_, 1586. 204 (first edition _La Rochelle_, 1578).

[743] _Histoire du Nouveau Monde_, Leyde, 1640. 503.

[744] _Hist. Rerum Nat. Brasil_. 1648. 37.

[745] _Botanica curiosa_, Helmst. 1697. 38.

[746] Duval, _Colonies et politique coloniale de la France_, 1864.
101.—Mavidal, _Le Sénégal, son état présent, son avenir_, Paris, 1863.
171.—Carrère et Holle, _La Sénégambie Française_, 1855. 84.—Poiteau, in
_Annales des Sciences nat., Botanique_, xix. (1853) 268.

The oil is exported from India where the ground-nut is also cultivated,
though not on so large a scale as in Western Africa. In Europe it
is manufactured chiefly at Marseilles, London, Hamburg and Berlin.
The yield of the seeds varies from 42 to nearly 50 per cent. The
softness of the seeds greatly facilitates their exhaustion, whether
by mechanical power or by the action of bisulphide of carbon or other
solvent.

=Uses=—Good arachis oil may be employed in pharmacy in the same way as
olive oil, for which it is a valuable substitute, though more prone to
rancidity. It has been introduced into the _Pharmacopœia of India_,
and is generally used instead of olive oil in the Indian Government
establishments. Its largest application is for industrial purposes,
especially in soap-making.


RADIX ABRI.

_Indian Liquorice_; F. _Liane à réglisse_, _Réglisse d’Amérique_.

=Botanical Origin=—_Abrus precatorius_ L., a twining woody shrub[747]
indigenous to India, but now found in all tropical countries.

=History=—The plant is mentioned in the Sanskrit medical writings of
Susruta, whence we may infer that it has long been employed in India.
Its resemblance to liquorice was remarked by Sloane (1700), who called
it _Phaseolus glycyrrhites_. As a substitute for liquorice, the root
has been often employed by residents in the tropical countries of both
hemispheres. It was introduced into the _Bengal Pharmacopœia_ of 1844,
and into the _Pharmacopœia of India_ of 1868.

The seeds, of the size of a small pea, well known for their polish and
beautiful black and red colours, have given their name of _Retti_ to a
weight (= 2³/₁₆ grains) used by Hindu jewellers and druggists.

=Description=—The root is long, woody, tortuous and branching. The
stoutest piece in our possession is as thick as a man’s finger, but
most of it is much more slender. The cortical layer is extremely thin
and of a light brown or almost reddish hue. The woody part breaks with
a short fibrous fracture exhibiting a light yellow interior. The root
has a peculiar, disagreeable odour, and a bitterish acrid flavour
leaving a faintly sweet after-taste. When cut into short lengths it has
a slight resemblance to liquorice, but may easily be distinguished by
means of the microscope.

Mr. Moodeen Sheriff,[748] who says he has often examined the root of
_Abrus_ both fresh and dried, remarks that it is far from abounding in
sugar as generally considered;—that it does not possess any sweetness
at all until it attains a certain size, and that even then its sweet
taste is not always well marked. As it is often mixed in the Indian
bazaars with true liquorice, he thinks the latter may have sometimes
been mistaken for it.

[747] Fig. in Bentley and Trimen, _Medicinal Plants_, part 25 (1878).

[748] _Supplement to the Pharmacopœia of India_, Madras, 1869. 16.—The
author has kindly sent us specimens of the root. We are also indebted
for authentic samples to Mr. Thwaites of the Royal Botanical Garden,
Ceylon, and to Mr. Prestoe of the Botanical Garden, Trinidad. The last
named gentleman remarks—“I do not find any liquorice property in the
root, even fresh, but it is very strong in the green leaves.”

=Microscopic Structure=—On a transverse section the bark exhibits some
layers of cork-cells, loaded with brown colouring matter, and then,
within the middle zone of the bark, a comparatively thick layer of
sclerenchymatous tissue. Strong liber-fibres are scattered through
the interior of the cortical tissue, but are not distributed so as to
form wedge-shaped rays as met with in liquorice. In the latter the
sclerenchyme (thick-walled cells) is wanting. These differences are
sufficient to distinguish the two roots.

=Chemical Composition=—The concentrated aqueous infusion of the root of
Abrus has a dark brown colour and a somewhat acrid taste accompanied
by a faint sweetness. When it is mixed with an alkaline solution of
tartrate of copper, red cuprous oxide is deposited after a short
time: hence we may infer that the root contains sugar. One drop of
hydrochloric or other mineral acid mixed with the infusion produces a
very abundant flocculent precipitate, which is soluble in alcohol. If
the infusion of Abrus root is mixed with a very little acetic acid,
an abundant precipitate is likewise obtained, but is dissolved by an
excess. This behaviour is similar to that of glycyrrhizin (see p. 181).

Berzelius observed, so long ago as 1827, that the _leaves_ of Abrus
contain a sweet principle similar to that of liquorice.

=Uses=—The root has been used in the place of liquorice, for which it
is in our opinion a very bad substitute.


SETÆ MUCUNÆ.

_Dolichi pubes vel setæ_; _Cowhage_, _Cow-itch_[749]; F. _Pois à
gratter_, _Pois pouillieux_; G. _Juckborsten_.

=Botanical Origin=—_Mucuna pruriens_ DC. (_Dolichos pruriens_ L.,
_Stizolobium pruriens_ Pers., _Mucuna prurita_ Hook.), a lofty climbing
plant[750] with large, dark purple papilionaceous flowers, and downy
legumes in size and shape not unlike those of a sweet pea, common
throughout the tropical regions of both Africa, India and America.

=History=—The earliest notice we have found of this plant is that of
Parkinson, who in his _Theater of Plants_, published in 1640, names it
“_Phaseolus siliquâ hirsutâ_, the Hairy Kidney-Beane called in Zurrate
[Surat] where it groweth, _Couhage_” It was subsequently described by
Ray (1686), who saw the plant raised from West Indian seeds, in the
garden of the Hatton family in Holborn.[751] Rheede figured it in the
_Hortus Malabaricus_,[752] and it was also known to Rumphius and the
other older botanists. We find it even in the pharmaceutical tariff of
the county of Nürnberg, A.D. 1714.[753]

[749] These names and the following are also applied to the entire
pods, or even to the plant.

[750] Fig. in Bentley and Trimen, _Med. Plants_, part 13 (1876).

[751] _Hist. Plant._ i. 887.

[752] Tom. viii. (1700) tab. 35, sub nom. _Nāi Corana_.

[753] Flückiger, _Documente zur Geschichte der Pharmacie_, Halle, 1876.
84.

The employment of cowhage as a vermifuge originated in the West Indies,
and is quite unknown in the East. In England the drug began to attract
attention in the latter part of the last century, when it was strongly
recommended by Bancroft in his _Natural History of Guiana_ (1769),
and by Chamberlaine, a surgeon of London, who published an essay[754]
descriptive of its effects which went through many editions. It was
introduced into the Edinburgh Pharmacopœia of 1783, and into the
London Pharmacopœia of 1809. At the present day it has been almost
discarded from European medicine, but has been allowed a place in the
_Pharmacopœia of India_ (1868).

The name _Cowhage_ is Hindustani, and in the modern way is written
_Kiwânch_, which is generally derived from the Sanskrit _Kapi-Kachchu_,
monkey’s itch (Dr. Rice); the corruption into _Cow-itch_ is absurd.
_Mucuna_ is the Brazilian name of another species mentioned in 1648 by
Marcgraf.[755]

=Description=—The pods are 2 to 4 inches long, about ⁴/₁₀ of an inch
wide, and contain 4 to 6 seeds; they are slightly compressed and of a
dark blackish brown. Each valve is furnished with a prominent ridge
running from the apex nearly to the base, and is densely covered with
rigid, pointed, brown hairs, measuring about ⅒ of an inch in length.
The hairs are perfectly straight and easily detached from the valves,
out of the epidermis of which they rise. If incautiously touched, they
enter the skin and occasion an intolerable itching.

=Microscopic Structure=—Under the microscope the hairs are seen to
consist of a single, sharply pointed, conical cell, about ¹/₄₀ of an
inch in diameter at the base, with uniform brownish walls 5 mkm. thick,
which towards the apex are slightly barbed. Occasionally a hair shows
one or two transverse walls. Most of the hairs contain only air; others
show a little granular matter which acquires a greenish hue on addition
of alcoholic solution of perchloride of iron. If moistened with chromic
acid, no structural peculiarity is revealed that calls for remark.
The walls however are somewhat separated into indistinct layers, the
presence of which is confirmed by the refractive power displayed by the
hairs in polarized light.

=Chemical Composition=—The hairs when treated with sulphuric acid and
iodine assume a dark brown colour. Boiling solution of potash does not
considerably swell or alter them. They are completely decolorized by
concentrated nitric acid.

=Uses=—Cowhage is administered for the expulsion of intestinal worms,
especially _Ascaris lumbricoides_ and _A. vermicularis_, which it
effects by reason of its mechanical structure. It is given mixed with
syrup or honey in the form of an electuary.

The root and seeds are reputed medicinal by the natives of some part of
India. The pods when young and tender may be cooked and eaten.

[754] _On the efficacy of Stizolobium or Cowhage_, Lond. 2nd ed. 1784.

[755] _Hist. Nat. Brasil._ 18.


SEMEN PHYSOSTIGMATIS.

_Faba Calabarica_, _Faba Physostigmatis_; _Calabar Bean_, _Ordeal Bean
of Old Calabar_, _Eseré Nut_, _Chop-nut_; F. _Fève de Calabar_; G.
_Calabarbohne_.

=Botanical Origin=—_Physostigma venenosum_ Balfour, a perennial plant
resembling the common Scarlet Runner (_Phaseolus multiflorus_ Lam.)
of our gardens, but having a woody stem often an inch or two thick,
climbing to a height of 50 feet or more. It grows near the mouths of
the Niger and the Old Calabar River in the Gulf of Guinea.

The imported seeds germinate freely, but the plant, though it thrives
vigorously in a hothouse, has not yet, we believe, flowered in Europe.
It has already been introduced into India and Brazil. In the latter
country Dr. Peckolt, late of Cantagallo, has raised plants which have
blossomed abundantly, producing racemes of about 30 flowers each,
pendent from the axils of the ternate leaves.

The flower, which is fully an inch across and of a purplish colour, has
the form of _Phaseolus_, but is distinguished from that genus by two
special characters, namely that it has the style developed beyond the
stigma backwards as a broad, flat, hooked appendage,[756] and the seeds
half surrounded by a deeply grooved hilum.

=History=—The pagan tribes of Tropical Western Africa compel persons
accused of witchcraft to undergo the ordeal of swallowing some
vegetable poison. One of the substances employed in this horrid custom
is the seed under notice, which is administered in substance or in
the form of emulsion, or even as a clyster. It was first made known
in England by Dr. W. F. Daniell about the year 1840, and subsequently
alluded to in a paper read by him before the Ethnological Society in
1846.[757] The highly poisonous effects of the bean were observed in
1855 by Christison[758] in his own person, and in 1858 by Sharpey, who
administered it to frogs.

Before the seed became an object of commerce, it was regarded by the
natives with some mystery and was reluctantly parted with to Europeans.
It was moreover customary in Old Calabar to destroy the plant whenever
found, a few only being reserved to supply seeds for judicial purposes,
and of these seeds the store was kept in the custody of the native
chief. In 1859, the Rev. W. C. Thomson, a missionary on the West Coast
of Africa, forwarded the plant to Professor Balfour of Edinburgh, who
figured and described it as a type of a new genus.[759]

[756] The name of the genus, from ϕύσα, a bladder, was formed under the
notion that this appendage is _hollow_, which is not the fact.—Mucuna
cylindrosperma Welwitsch, from Angola, is probably the same plant. See
Holmes, _Pharm. J._ ix. (1879) 913.

[757] Edinb. _New Phil. J._ xl. (1846) 313.

[758] _Edinb. Journ. of Medical Science_, xx. (1855) 193; _Pharm.
Journ._ xiv. (1855) 470.

[759] _Trans. Roy. Soc. of Edinb._ xxii. (1861) 305. t. 16-17; see also
Baillon, _Hist. des Plantes_, ii. 206. figg. 153-155, and Bentley and
Trimen, _Med. Plants_, part 6 (1876).

Fraser of Edinburgh (about 1863 or earlier) discovered the specific
power of the seed in contracting the pupil, when the alcoholic extract
is applied to the eye. These myotic effects, counteracting those
of atropine and hyoscyamine, were further examined by many other
experimenters on mammals or birds. The action of the poison when taken
internally was found rapidly to affect the cardiac contractions and
finally to paralyze the heart.

=Description=—The fruit of _Physostigma_ is a dehiscent, oblong legume
about 7 inches in length, containing 2 or 3 seeds. The latter, commonly
known as _Calabar Beans_, are 1 to 1⅜ inches long, about ⁶/₈ of an inch
broad, and ⁴/₈ to ⅝ of an inch in thickness, weighing on an average
twenty seeds, 67 grains each.

They have an oblong, subreniform outline, one side being straight or
but slightly incurved, the other boldly arched. The latter is marked
by a broad furrow, ⅛ of an inch wide, bordered with raised edges, and
running from the micropyle, which is a small funnel-shaped depression,
quite round the opposite end of the seed. In the middle of this
remarkable furrow the raphe is seen as a long raised suture running
from end to end. The surface of the seed is somewhat rough, but has a
dull polish; it is of a deep chocolate-brown, passing into a lighter
tint on the ridges bordering the furrow. The latter is black, dull, and
finely rugose.

When the seed is broken the cotyledons are found adherent to the
testa, with a large cavity between them. The air thus included causes
the seeds to float on water, but they sink immediately when broken.
After digestion for some hours in warm water, the testa having been
previously cracked, the whole seed softens and swells so that its
structure may be easily studied. Each cotyledon is then seen to be
marked on the hilum-side by a long shallow furrow, at one end of
which, just below the micropyle, lies the plumule and radicle. A dark
brown inner membrane, constituting part of the testa, surrounds the
cotyledons.

The seeds have scarcely any taste, or not more than an ordinary bean;
nor in the dry state have they any odour. After being boiled, or when
their alcoholic tincture is evaporated, an odour suggesting cantharides
is developed.

=Microscopic Structure=—The cotyledons are built up of large globular
or ovoid cells, those of the outermost layer being smaller and of
rather cubic form. This parenchyme is loaded with starch granules,
frequently as much as 50 mkm. in diameter. Their interior part is less
distinctly stratified than the outer; the hollow centre radiates in
various directions around the axis of the ovate granule. Polarized
light does not show a cross as in other more globular starch granules,
but two elliptic curves approaching one another near the axis of the
granule. Similar starch granules are commonly met with in the seeds of
_Leguminosæ_.

In the Calabar seeds the starch is accompanied by numerous particles
of albuminous matter becoming distinctly perceptible by addition of
iodine, which imparts to them an orange colouration.

The shell of the seed is built up of four different layers; the
prevailing layer consists of very long, simply cylindrical cells,
densely packed so as to form only one radial row. Tison[760] has
endeavoured to ascertain in what region of the seed the active
principle is lodged; and he has arrived at the conclusion that its seat
is the granular protoplasmic particles, which alone acquire an orange
tint by the action of weak caustic alkalis.

[760] _Histoire de la Fève de Calabar_, Paris, 1873. 38.

=Chemical Composition=—Jobst and Hesse[761] proved in 1863 that the
poisonous nature of Calabar bean depends upon an alkaloid, to which
they gave the name _Physostigmine_. It is obtained by the method
generally adopted for extracting analogous substances, that is, by
precipitating one of its salts from an aqueous solution by bicarbonate
of sodium, and dissolving out the base with ether or benzol. As
extracted by these chemists, physostigmine is an amorphous mass of
decidedly alkaline reaction, soluble in much water and in acids.
On exposure to the air the solution soon becomes red, or sometimes
intensely blue, a partial decomposition of the alkaloid taking place.
The red coloration may even be observed in the aqueous infusion of a
few cotyledons. It disappears by sulphuretted hydrogen or sulphurous
acid, but returns if these reducing agents are allowed to evaporate.

Hesse[762] ascertained (1867) that physostigmine consists of
C₃₀H₂₁N₃O₄; he now obtained it perfectly colourless and tasteless,
softening at 40° C., fusing at 45°, but not supporting a heat of 100°
C., without decomposition, which is manifested by a red coloration.

In 1865 Vée and Leven,[763] by treating the powdered unpeeled seed in
nearly the same way, prepared an alkaloid which they called _Eserine_.
It differs from Hesse’s physostigmine in that it forms colourless,
rhomboidal, tabular crystals of a bitter taste, melting at 90° C. It
dissolves easily in ether, alcohol, or chloroform, but very sparingly
in water. The last named solution is alkaline, and reddens by exposure
to the air.

It is assumed by some writers, as Tison,[764] that eserine is only the
pure form of physostigmine; but at present we feel hardly warranted in
admitting the identity of the two substances.

Harnack and Witkowski in 1876 ascertained the presence of another
alkaloid in the seed, which they called _Calabarine_. It is nearly
insoluble in ether and also very different from physostigmine in its
physiological action, but somewhat similar to strychnine. Calabarine
is consequently not to be found in those preparations of calabar bean
which have been obtained or purified by means of ether.

Hesse (1878) exhausted the cotyledons of Physostigma with petroleum
ether, and obtained crystals of a new indifferent substance C₂₆H₄₄+OH₂,
which he called _Phytosterin_. It is closely allied to Cholesterin,
but, in its solution in chloroform, devoid of rotatory power and
melting at 133°. Cholesterin melts at 145°, and deviates, in its
ethereal solution, the ray of polarized light to the left. Phytosterin
also occurs in peas; Hesse suggests that the crystallized appearance
of alkaloids as prepared by former observers was perhaps due to
phytosterin.

From the cotyledons _per se_, cold water extracts mucilage,
precipitable by neutral acetate of lead. The watery infusion contains
also albumin, which may be coagulated by heat or by alcohol. The
infusion is colourless, does not redden litmus, nor does it contain
sugar in appreciable proportion; a few drops of solution of potash
cause it to assume an orange colour. An infusion of the shell of the
seed is already of this colour, but the tint is intensified by caustic
alkali.

[761] Liebig’s _Annalen der Chem. u. Pharm._ 129 (1864) 115.

[762] _Ibid._ 141 (1867) 82; _Chem. News_, 22 March 1867, 149.

[763] _Comptes Rendus_, lx. (1865) 1194.

[764] _Op. cit._ chap. 2.

The cotyledons yield to boiling ether ½ to ⅓ per cent. of fatty oil,
and after exhaustion by ether and alcohol, afford to cold water 12 per
cent. of albuminous and mucilaginous constituents. The proportion of
starch according to Teich[765] amounts to 48 per cent., the albuminous
matter to 23 per cent. The entire seed furnishes 3 per cent. of ash,
chiefly phosphate of potash. These constituents do not widely differ
in proportion from those found in the common bean, which yields 23 to
25 per cent. of albuminous matters, and 32 to 38 per cent. of starch,
besides 1 to 3 per cent. of oil.

[765] _Chemische Untersuchung der Calabarbohne_.—Inauguralschrift, St.
Petersburg, 1867. We calculate the albuminous matters with reference to
_Teich’s_ analysis, which proved the kernels to contain 3·65 per cent.
of nitrogen.

The shells of Calabar bean are stated by Fraser to be by no means
devoid of active principle.

Vée asserts that if to a solution of eserine, a little potash, lime,
or carbonate of sodium be added, there is developed a red colour which
rapidly increases in intensity. This colour is transient, passing into
yellow, green and blue. If chloroform is shaken with such coloured
solution, it takes up the colour; ether on the other hand remains
uncoloured.

=Uses=—Calabar has been hitherto chiefly employed as an ophthalmic
medicine, for the purpose of contracting the pupil. It has however been
occasionally administered in tetanus and in neuralgic, rheumatic, and
other diseases.

=Adulteration=—Other seeds are sometimes fraudulently mixed with
Calabar beans. We have noticed in particular those of a _Mucuna_ and
of the Oil Palm, _Elæis guineensis_ Jacq. The slightest examination
suffices for their detection.


KINO.

_Kino_, _Gum Kino_, _East Indian Kino_; F. and G. _Kino_.

=Botanical Origin=—_Pterocarpus Marsupium_ Roxb., a handsome tree 40 to
80 feet high, frequent in the central and southern parts of the Indian
Peninsula and also in Ceylon, and affording a valuable timber. In the
Government forests of the Madras Presidency, it is one of the _reserved
trees_, the felling of which is placed under restrictions.

_Pt. indicus_ Willd., a tree of Southern India, the Malayan Peninsula
and the Indian and Philippine Islands, is capable of yielding kino, and
is the source of the small supplies of that drug that were formerly
shipped from Moulmein.

Several other plants afford substances bearing the name of _Kino_,
which will be noticed at the conclusion of the present article.

=History=—The introduction of kino into European medicine is due to
Fothergill, an eminent physician and patron of economic botany of
the last century. The drug which Fothergill examined was brought from
the river Gambia in West Africa as a rare sort of Dragon’s Blood, and
was described by him in 1757[766] under the name of _Gummi rubrum
astringens Gambiense_. It had been noticed at least twenty years before
as a production of the Gambia, by Moore, factor to the Royal African
Company, who says that the tree yielding it is called in the Mandingo
language _Kano_.[767] Specimens of this tree were sent to England in
1805 by the celebrated traveller Mungo Park, and recognized some years
later as identical with the _Pterocarpus erinaceus_ of Poiret.

It seems probable that African kino continued to reach England for some
years, for we find “_Gummi rubrum astringens_” regularly valued in the
stock of a London druggist[768] from 1776 to 1792.

Duncan in the _Edinburgh Dispensatory_ of 1803, while asserting
that “_kino is brought to us from Africa_,” admits that some, not
distinguishable from it, is imported from Jamaica. In a later edition
of the same work (1811), he says that the African drug is no longer
to be met with, and alludes to its place being supplied by other
kinds, as that of Jamaica, that imported by the East India Company,
and that of New South Wales derived from _Eucalyptus resinifera_ Sm.
It will thus be seen that at the commencement of the present century
several substances, produced in widely distant regions, bore the name
of _Kino_. That however which was principally used in the place of
the old African drug, was _East Indian_ Kino, the botanical origin of
which was shown by Wight and by Royle[769] (1844-46) to be _Pterocarpus
Marsupium_ Roxb.,—a tree which, curiously enough, is closely allied to
the kino tree of Tropical Africa.

This is the drug which is recognized as legitimate kino in all the
principal pharmacopœias of Europe. It appears to have been first
prepared for the European market in the early part of the present
century, on a plantation of the East India Company called Anjarakandy,
a few miles from Tellicherry on the Malabar Coast; but as we learn from
our friend Dr. Cleghorn, it was not grown there but on the ghats a
short distance inland.

=Extraction=—Kino is the juice of the tree, dried without artificial
heat.[770] As it exudes, it has the appearance of red currant
jelly, but hardens in a few hours after exposure to the air. In the
Government forests of the Malabar Coast whence the supplies are
obtained, permission to collect the drug is granted on payment of a
small fee, and on the understanding that the tapping is performed
skilfully and without damage to the timber. The method pursued is
this:—A perpendicular incision with lateral ones leading into it, is
made in the trunk, at the foot of which is placed a vessel to receive
the outflowing juice. This juice soon thickens, and when sufficiently
dried by exposure to the sun and air, is packed into wooden boxes for
exportation.

=Description=—Malabar kino[771] consists of dark, blackish-red,
angular fragments rarely larger than a pea, easily splitting into
still smaller pieces, which are seen to be perfectly transparent, of a
bright garnet hue, and amorphous under the microscope. In cold water
they sink, but partially dissolve by agitation, forming a solution
of very astringent taste, and a pale flocky residue. The latter is
taken up when the liquid is made to boil, and deposited on cooling in
a more voluminous form. Kino dissolves almost entirely in spirit of
wine (·838), affording a dark reddish solution, acid to litmus paper,
which by long keeping sometimes assumes a gelatinous condition. It is
readily soluble in solution of caustic alkali, and to a large extent in
a saturated solution of sugar.

[766] _Medical Observations and Inquiries_, i. (1757) 358.

[767] _Travels into the Inland Parts of Africa_, by Francis Moore,
Lond. 1737. pp. 160. 209. 267.

[768] J. Gurney Bevan, Plough Court, Lombard Street.—The drug was
priced in 1787 as having cost 16_s._, and in 1790-92, 21_s._ per lb.

[769] _Pharm. Journ._ v. (1846) 495.

[770] Cleghorn, _Forests and Gardens of South India_, 1861. 13.—Also
from information communicated by him orally.

[771] Our sample obtained from _Pt. Marsupium_ Roxb. on the Sigúr Ghat,
Feb. 1868, was kindly submitted to us by Mr. McIvor of Ootacamund.—We
find it to agree with commercial East Indian Kino.

=Chemical Composition=—Cold water forms with kino a reddish solution,
which is at first not altered if a fragment of ferrous sulphate is
added. But a violet colour is produced as soon as the liquid is
cautiously neutralized. This can be done by diluting it with common
water (containing bicarbonate of calcium) or by adding a drop of
solution of acetate of potassium. Yet the fact of kino developing an
intense violet colour in presence of a proto-salt of iron, may most
evidently be shown by shaking it with water, and iron reduced by
hydrogen. The filtered liquid is of a brilliant violet, and may be
evaporated at 100° without turning green; the dried residue even again
forms a violet solution with water. By long keeping the violet liquid
gelatinizes. It is decolorized by acids, and turns red on addition
of an alkali, whether caustic or bicarbonated. Catechu, as well as
crystallized catechin, show the same behaviour, but these solutions
quickly turn green on exposure to air.

Solutions of acids, of metallic salts, or of chromates produce copious
precipitates in an aqueous solution of kino. Ferric chloride forms a
dirty green precipitate, and is at the same time reduced to a ferrous
salt. Dilute mineral acids or alkalis do not occasion any decided
change of colour, but the former give rise to light brownish-red
precipitates of _Kino-tannic Acid_. By boiling for some time an aqueous
solution of kino-tannic acid, a red precipitate, _Kino-red_, is
separated.

Kino in its general behaviour is closely allied to Pegu catechu,
and yields by similar treatment the same products, that is to say,
it affords _Pyrocatechin_ when submitted to dry distillation, and
_Protocatechuic Acid_ together with _Phloroglucin_ when melted with
caustic soda or potash.

Yet in catechu the tannic acid is accompanied by a considerable amount
of catechin, which may be removed directly by exhaustion with ether.
Kino, on the other hand, yields to ether only a minute percentage
of a substance, whose scaly crystals display under the microscope
the character of _Pyrocatechin_, rather than that of catechin, which
crystallizes in prisms. The crystals extracted from kino dissolve
freely in cold water, which is not the case with catechin, and this
solution assumes a fine green if a very dilute solution of ferric
chloride is added, and turns red on addition of an alkali. This is the
behaviour of catechin as well as of pyrocatechin; but the difference
in solubility speaks in favour of the crystals afforded by kino being
pyrocatechin rather than catechin.

We thought pyrocatechin must also occur in the mother plant of kino,
but this does not prove to be the case, no indication of its presence
being perceptible either in the fresh bark or wood.[772]

Etti (1878) extracted from kino colourless prisms of _Kinoïn_ by
boiling the drug with twice its weight of hydrochloric acid, about 1·03
sp. gr. On cooling, kino-red separates, very little of it remaining in
solution together with kinoïn. The latter is extracted by exhausting
the liquid with ether, which by evaporation affords crystals of kinoïn.
They should be recrystallized from boiling water; they agree with the
formula C₁₄H₁₂O₆, which is to be regarded as that of a methylated
gallic ether of pyrocatechin, viz., C₆H₄ (OCH₃) C₇H₅O₅.

Kinoïn by heating it to 130° C. gives off water and turns red:

    2 C₁₄H₁₂O₆ = OH₂ · C₂₈H₂₂O₁₁.

The latter product is an amorphous mass agreeing with kino-red; by
heating it at 160-170° it again loses water, thus affording another
anhydride.

Etti succeeded in preparing methylic chloride, pyrocatechin CH₄(OH)₂ as
well as gallic acid C₇H₆O₅, by decomposing kinoïn.

We have prepared kinoïn from _Australian kino_ (see page 198), but
failed in obtaining it from Malabar kino, which however Etti states to
have used. Kino affords about 1½ per cent. of kinoïn.

The solutions of kinoïn turn red on addition of ferric salts.

Commercial kino yielded us 1·3 per cent. of ash.

=Commerce=—The quantity of true kino collected in the Madras forests is
comparatively small, probably not exceeding a ton or two annually. The
drug is often shipped from Cochin.

=Uses=—Kino is administered as an astringent. It is said to be used in
the manufacture of wines, and it might be employed if cheap enough in
tanning and dyeing.

Other sorts of Kino.

1. _Butea Kino_, _Butea Gum_, _Bengal Kino_, _Palas or Pulas Kino_,
_Gum of the Palas or Dhak Tree_.

This is an exudation from _Butea frondosa_ Roxb. (_Leguminosæ_), a
tree of India and Burma, well known under the name of _Palas_ or
_Dhak_, and conspicuous for its splendid, large, orange, papilionaceous
flowers.[773] According to Roxburgh it flows during the hot season from
natural fissures or from wounds made in the bark, as a red juice which
soon hardens into a ruby-coloured, brittle, astringent gum.

[772] We have to thank Mr. Broughton, late of the Cinchona Plantations,
Ootacamund, for determining this point. In the bark almost saturated
with fresh liquid kino, he utterly failed to obtain any indication of
pyrocatechin by the tests which he found to render it easily evident in
dry kino.

[773] See Nees von Esenbeck, _Plantæ medicinales_, Düsseldorf, iii.
(1833) tab. 79.

Authentic specimens of this kino have been placed at our disposal by
Mr. Moodeen Sheriff of Madras and by Dr. J. Newton of Bellary. That
received from the first-named gentleman consists of flattish, angular
fragments (the largest about ½ an inch across) and small drops or
tears of a very dark, ruby-coloured gum, which when held to the light
is seen to be perfectly transparent. The flat pieces have been mostly
dried on leaves, an impression of the veins of which they retain on
one side, while the other is smooth and shining. The substance has a
pure astringent taste, but no odour. It yielded us 1·8 per cent. of ash
and contained 13·5 per cent. of water. Ether removes from it a small
quantity of _pyrocatechin_. Boiling alcohol dissolves this kino to the
extent of 46 per cent.; the solution which is but little coloured,
produces an abundant greyish-green precipitate with perchloride of
iron, and a white one with acetate of lead. It may be hence inferred
that a tannic acid, probably kino-tannic acid, constitutes about half
the weight of the drug, the remainder of which is formed of a soluble
mucilaginous substance which we have not isolated in a state of purity.
By submitting the Butea kino of Mr. Moodeen Sheriff to dry distillation
we obtained pyrocatechin.

The sample from Dr. Newton is wholly in transparent drops and
stalactitic pieces, considerably paler than that just described, but of
the same beautiful ruby tint. The fragments dissolve freely and almost
completely in cold water, the solution being neutral and exhibiting the
same reactions as the former sample.

Butea kino, which in India is used in the place of Malabar kino, was
long confounded with the latter by European pharmacologists, though
the Indian names of the two substances are quite different. It is not
obtained exclusively from _B. frondosa_, the allied _B. superba_ Roxb.
and _B. parviflora_ Roxb. affording a similar exudation.

2. _African or Gambia Kino._—Of this substance we have a specimen
collected by Daniell[774] in the very locality whence it was obtained
by Moore in 1733 (see p. 195), and by Park at the commencement of the
present century. The tree yielding it, which still bears the Mandingo
name _Kano_, and grows to a height of 40 to 50 feet, is _Pterocarpus
erinaceus_ Poiret, a native of Tropical Western Africa from Senegambia
to Angola. The juices exude naturally from crevices in the bark, but
much more plentifully by incisions; it soon coagulates, becoming deep
blood-red and remarkably brittle. That in our possession is in very
small, shining, angular fragments, which in a proper light appear
transparent and of a deep ruby colour. In solubility and chemical
characters, we can trace no difference between it and the kino of the
allied _Pt. Marsupium_ Roxb. This kino does not now find its way to
England as a regular article of trade. From the statement of Welwitsch,
it appears that the Portuguese of Angola employ it under the name of
_Sangue de Drago_.[775]

3. _Australian, Botany Bay, or Eucalyptus Kino._—For some years past,
the London drug market has been supplied with considerable quantities
of kino from Australia; in fact at one period this kino was the only
sort to be purchased.

[774] See his paper _On the Kino Tree of West Africa, Pharm. Journ._
xiv. (1855) 55.

[775] _Madeiras e Drogas medicinaes de Angola_, Lisboa, 1862, 37.

As it is the produce of numerous species of _Eucalyptus_, it is not
surprising that it presents considerable diversity of appearance. The
better qualities closely agree with Pterocarpus kino. They are in
dark reddish-brown masses or grains, which when in thin fragments are
seen to be transparent, of a garnet red hue and quite amorphous. The
substance is mostly collected by the sawyers and wood-splitters. It is
found within the trunks of trees of all sizes, in flattened cavities of
the otherwise solid wood which are often parallel to the annual rings.
In such place the kino, which is at first a viscid liquid, becomes
inspissated and subsequently hard and brittle. It may also be obtained
in a liquid state by incisions in the stems of growing trees: such
liquid kino has occasionally been brought into the London market; it is
a viscid treacle-like fluid, yielding by evaporation about 35 per cent.
of solid kino.[776]

Authentic specimens of the kino of 16 species of _Eucalyptus_ sent
from Australia by F. von Müller, have been examined by Wiesner of
Vienna.[777] He found the drug to be in most cases readily soluble in
water or in spirit of wine, the solution being of a very astringent
taste. The solution gave with sulphuric acid a pale red, flocculent
precipitate of _Kino-tannic Acid_; with perchloride of iron (as in
common kino) a dusky greenish precipitate,—except in the case of the
kino of _E. obliqua_ L’Hér. (Stringy-bark Tree), the solution of which
was coloured dark violet.

Wiesner further states, that Eucalyptus kino affords a little
_Catechin_[778] and _Pyrocatechin_. It contains no pectinous matter,
but in some varieties a gum-like that of _Acacia_. In one sort, the
kino of _E. gigantea_ Hook,[779] gum is so abundant that the drug is
nearly insoluble in spirit of wine.

By Etti’s process, as given at page 197, we obtained kinoïn from an
Australian Kino, which contained numerous fragments of the wood. We
noticed that both Australian and Malabar kino emitted a somewhat
balsamic odour, when they were treated with hydrochloric acid.

From this examination, it is evident that the better varieties of
Eucalyptus kino, such for instance as those derived from _E. rostrata_
Schlecht. (_Red_ or _White Gum_, or _Flooded Gum_ of the colonists),
_E. corymbosa_ Sm. (_Blood-wood_) and _E. citriodora_ Hook., possess
the properties of Pterocarpus kino and might with no disadvantage be
substituted for it.

[776] Victoria Exhibition, 1861.—Jurors’ Report on Class 3. p. 59.

[777] _Zeitschrift des österreich. Apotheker-Vereines_ ix. (1871) 497;
_Pharm. Journ._ Aug. 5, 1871. 102.

[778] In our opinion this is doubtful.

[779] Bentham unites this species to _E. obliqua_ L’Hér (_Flor. Austr._
iii. 204).


LIGNUM PTEROCARPI.

_Lignum Santalinum rubrum_, _Santalum rubrum_; _Red Sanders Wood_,
_Ruby Wood_; F. _Bois de Santal rouge_; G. _Rothes Sandelholz_,
_Caliaturholz_.

=Botanical Origin=—_Pterocarpus santalinus_ Linn. fil.—A small tree not
often exceeding 3½ to 4 feet in girth, and 20 to 25 feet in height;
it is closely related to _Pt. Marsupium_ Roxb., from which it differs
chiefly in having broader leaflets always in threes. It is a native
of the southern part of the Indian Peninsula, as Canara, Mysore,
Travancore and the Coromandel Coast, but also occurs in Mindanao, in
the southern Philippines. In India the districts in which the wood is
at present chiefly obtained are the forests of the southern portion of
the Kurnool Hills, Cuddapah and North Arcot (W. and N.W. of Madras).
The tree is now being raised in regular plantations.[780]

The wood is a staple article of produce, and the felling of the trees
is strictly controlled by the forest inspectors. The fine trunk-wood
is highly valued by the natives for pillars in their temples and other
buildings, as well as for turnery. The stumps and roots are exported to
Europe as a dye-stuff, mostly from Madras.

=History=—It is difficult to tell whether the appellation _Red_
Sandal-wood used in connexion with _Yellow_ and _White_ Sandal-wood
by some of the earlier writers on drugs, was intended to indicate
the inodorous dyewood under notice or the aromatic wood of a species
of _Santalum_. Yet when Marco Polo[781] alludes to the sandal-wood
imported into China, and to the _red_ sandal (“_Cendal vermeil_”) which
grows in the island of Necuveran (Nicobar), it is impossible to doubt
that he intended by this latter name some such substance as that under
notice.

Garcia de Orta, who wrote at Goa in the middle of the 16th century,
clearly distinguished the fragrant sandal of Timor from the red
inodorous wood of Tenasserim and the Coromandel Coast. It is remarkable
that the wood of _Pt. santalinus_ is distinguished to the present
day in all the languages of India by names signifying _red-coloured
sandal-wood_, though it has none whatever of the peculiarities of the
odorous wood of _Santalum_. Red Sanders Wood was formerly supposed to
possess medicinal powers: these are now disregarded, and it is retained
in use only as a colouring agent.

During the middle ages, it was used as well as alkanet for culinary
purposes, such as the colouring of sauces and other articles of food.
The price in England between 1326 and 1399 was very variable, but on an
average exceeded 3_s._ per lb.[782] Many entries for the purchase of
Red Sanders along with spices and groceries, occur in the accounts of
the Monastery of Durham, A.D. 1530-34.[783]

=Description=—The wood found in English commerce is mostly that of the
lower parts of the stem and that of the thickest roots. It appears
in the market in ponderous, irregular logs, rarely exceeding the
thickness of a man’s thigh and commonly much smaller, 3, 4 or 5 feet in
length; they are without bark or sapwood, and are externally of a dark
colour. The internal wood is of a deep, rich, blood-red, exhibiting in
transverse section zones of a lighter tint, and taking a fine polish.

At the present day, druggists generally buy the wood rasped into small
chips, which are of a deep reddish-brown hue, tasteless and nearly
without odour.


[780] (Beddome), _Report of the Conservator of Forests_, for 1869-70,
Madras, 1870, pp. 3. 39. 123; for figure of the tree, see _Flora
Sylvatica of Southern India_ of the same author, tab. xxii.

[781] Pauthier, _Livre de Marco Polo_, 580—_Pt. indicus_ Willd. grows
in the adjacent Andaman Islands.

[782] Rogers, _Agriculture and Prices in England_, 1866, i. 631, ii.
545, &c.—The average price of a sheep during the same period was about
1_s._ 6_d._

[783] _Durham Household Book_, Surtees Soc. 1844. 215; also Pegge,
_Form of Cury_, Lond. 1780. p. xv.

=Microscopic Structure=—The wood is built up for the greater part
of long pointed cells, having thick walls (libriform). Through this
ligneous tissue, there are scattered small groups of very large
vessels. In a direction parallel to the circumference of the stem,
there are less coloured small parenchymatous layers, running from one
vascular bundle to another. The whole tissue is finally traversed by
very narrow medullary rays, which are scarcely perceptible to the
unaided eye. The parenchymatous cells are each loaded with one crystal
of oxalate of calcium, which are so large that, in a piece of the wood
broken longitudinally, they may be distinguished without a lens. The
colouring matter is contained especially in the walls of the vessels
and the ligneous cells.

=Chemical Composition=—Cold water or fatty oil (almond or olive)
abstracts scarcely anything from the wood, and hot water but very
little. On the other hand, ether, spirit of wine, alkaline solutions,
or concentrated acetic acid, readily dissolves out the colouring
matter. Essential oils of bitter almond or clove take up a good deal
of the red substance; that of turpentine none at all. This resinoid
substance, termed _Santalic Acid_ or _Santalin_,[784] is said to form
microscopic prismatic crystals of a fine ruby colour, devoid of odour
and taste, fusing at 104° C., insoluble in water but neutralizing
alkalis and forming with them uncrystallizable salts.

Weidel (1870) exhausted the wood with boiling water, containing a
little potash, and obtained by means of hydrochloric acid a red
precipitate, which was redissolved in boiling alcohol and then
furnished _colourless_ crystals of _Santal_, C₈H₆O₃. They are devoid of
odour or taste, not soluble in water, benzol, chloroform, bisulphide of
carbon, and but sparingly in ether. Santal yields with potash a faintly
yellow solution which soon turns red and green. The wood afforded
Weidel not more than 3 per mille of santal.

Cazeneuve (1874)[785] mixed 4 parts of the wood with 1 part of slaked
lime, and exhausted the dried powder with ether containing a little
alcohol. After the evaporation of the ether, a small amount of
colourless crystals of _Pterocarpin_ was obtained, which were purified
by recrystallization from boiling alcohol. They melt at 83° C., and are
abundantly soluble in chloroform, in bisulphide of carbon, very little
in cold alcohol, not at all in water. Pterocarpin agrees with the
formula C₁₇H₁₆O₅. It yields a red solution with concentrated sulphuric
acid, and a green with nitric acid 1·4 sp. gr. By submitting it to
destructive distillation pyrocatechin appears to be formed.

Franchimont (1879) assigns the formula C₁₇H₁₆O₆ to another principle
of Red Sanders Wood, which he isolated by means of alcohol. It is
an amorphous substance, melting at 105°. By extracting the wood
with a solution of carbonate of sodium, Hagenbach (1872) obtained a
fluorescent solution. Red Sanders Wood yielded us of ash only 0·8 per
cent.

=Commerce=—In the official year 1869-70, Red Sanders Wood produced to
the Madras Government a revenue of 26,015 rupees (£2,601). The quantity
taken from the forests was reported as 1,161,799 lb.

[784] Gmelin, _Chemistry_, xvi. (1864) 259; the formula assigned to
santalic acid (C₁₅H₁₄O₅) appears to be doubtful. Weidel in proposing
the formula C₁₄H₁₂O₄ points out that it may be allied to alizarin,
C₁₄H₈O₄.

[785] See _Dictionnaire de Chimie_, art. _Santaline_, p. 1434, and for
particulars: Cazeneuve, _Recherche et extraction des alcaloïdes_, etc.
Paris, 1875. 66. It would appear that the author obtained about 4 per
_mille_ of pterocarpin from the wood.

=Uses=—Red Sanders Wood is scarcely employed in pharmacy except for
colouring the Compound Tincture of Lavender; but it has numerous uses
in the arts. The latter applies also to the wood of _Pterocarpus
angolensis_ DC., which is largely exported from the French colony of
Gaboon; it is the “Santal rouge d’Afrique of the French,” or Barwood of
the English commerce.


BALSAMUM TOLUTANUM.

_Balsam of Tolu_; F. _Baume de Tolu_; G. _Tolubalsam_.

=Botanical Origin=—_Myroxylon Toluifera_ H B K. (_Toluifera Balsamum_
Miller, _Myrospermum toluiferum_ A. Rich.),[786] an elegant and lofty
evergreen tree with a straight stem, often as much as 40 to 60 feet
from the ground to the first branch. It is a native of Venezuela, and
New Granada,—probably also of Ecuador and Brazil.

=History=—The first published account of Balsam of Tolu, is that of the
Spanish physician Monardes, who in his treatise on the productions of
the West Indies, which in its complete form first appeared at Seville
in 1574,[787] relates how the early explorers of South America observed
that the Indians collected this drug by making incisions in the trunk
of the tree. Below the incisions they affixed shells of a peculiar
black wax to receive the balsam, which being collected in a district
near Cartagena called _Tolu_, took its name from that place. He adds
that it is much esteemed both by Indians and Spaniards, that the latter
buy it at a high price, and that they have lately brought it to Spain,
where it is considered to be as good as the famous Balsam of Mecca.

Francisco Hernandez, who lived in 1561-1577 in Mexico, stated[788] that
the balsam of the province of Tolu was thought to be quite as useful
as, if not superior to, “balsamum indicum,” _i.e._ peruvianum.

A specimen agreeing with this description was given to Clusius[789]
in 1581 by Morgan, apothecary to Queen Elizabeth, but the drug was
certainly not common till a much later period. In the price-list of
drugs of the city of Frankfort of 1669, _Balsamus tolutanum_ (sic)
is expressly mentioned,[790] but there can be but little doubt
that _Balsamum Americanum resinosum_[791] or _siccum_ or _durum_
as occurring in many other tariffs of the 17th century, printed in
Germany, was also the balsam under notice;[792] in a similar list
emanating from the city of Basle in 1646,[793] we noticed _B. indicum
album_, _B. peruvianum_ and _B. siccum_,—the last with the explanatory
words, “_trockner Balsam in der Kürbsen_” (_i.e._ in gourds), meaning
probably balsam of Tolu.

[786] Fig. in Bentley and Trimen, _Med. Plants_, part 23 (1877)
under the name of _Toluifera Balsamum_. Though the change of names
may be justified by the strict rules of priority, we are of opinion
that at present it would be fraught with more of inconvenience than
advantage.—_Myroxylon punctatum_ Klotzsch, a tree stated to grow nearly
all over the northern part of South America, is referred to the same
species by Bentley and Trimen.

[787] _Historia de las cosas que se traen de nuestras Indias
occidentales_, cap. del Balsamo de Tolu.

[788] _Nova Plantarum, animal. et mineral. mexicanorum. Historia_,
Reccho’s edition, Romæ, 1651. fol. 53.

[789] _Exoticor._ etc. 1605. lib. x. fol. 305.

[790] _Pharm. Journ._ vi. (1876) 102.

[791] Pharmaceutical tariff (“Taxa”) of the city of Wittenberg 1632 (in
the Hamburg library).

[792] Flückiger, _Documente zur Geschichte der Pharmacie_, Halle, 1876.
49. 50. 53.—Balsamum _Peruvianum_ first occurs in the tariff of the
city of Worms of 1609.—_Documente_, p. 39; _Pharm. Journ. l. c._

[793] Contained in the _Medicine Tariffs_, in the library of the
British Museum, bound together in one volume ({777. c.}/5). They
include Schweinfurt 1614, Bremen 1644, Basle 1647, Rostock 1659,
Quedlinburg 1665, Frankfort on Main 1669 (quoted above).

As to the tree, of which Monardes figured a broken pod, leaflets of it,
marked 1758, exist in Sloane’s herbarium. Humboldt and Bonpland saw
it in several places in New Granada during their travels (1799-1804),
but succeeded only in gathering a few leaves. Among recent collectors,
Warszewicz, Triana, Sutton Hayes, and Seemann were successful only in
obtaining leaves. Weir in 1863 was more happy, for by causing a large
tree of nearly 2 feet diameter to be felled, he procured good herbarium
specimens including pods, but no flowers. Owing to this tree having
been much wounded for balsam, its foliage and fruits were singularly
small and stunted, and its branches overgrown with lichens.

That which botanists had failed to do, has been accomplished by an
ornithologist, Mr. Anton Goering, who, travelling in Venezuela to
collect birds and insects, made it a special object, at the urgent
request of one of us (H.), to procure complete specimens of the
Balsam of Tolu tree. By dint of much perseverance and by watching for
the proper season, Mr. Goering obtained in December 1868 excellent
flowering specimens and young fruits, and subsequently mature seeds
from which plants have been raised in England, Ceylon and Java.

=Extraction=—The most authentic information we possess on this
subject is derived from Mr. John Weir, plant collector to the Royal
Horticultural Society of London, who when about to undertake a journey
to New Granada in 1863, received instructions to visit the locality
producing Balsam of Tolu. After encountering considerable difficulties,
Mr. Weir succeeded in observing the manner of collecting the balsam in
the forest near Plato, on the right bank of the Magdalena. Mr. Weir’s
information[794] may be thus summarized:—

The balsam tree has an average height of 70 feet with a straight trunk,
generally rising to a height of 40 feet before it branches. The balsam
is collected by cutting in the bark two deep sloping notches, meeting
at their lower ends in a sharp angle. Below this =V=-shaped cut, the
bark and wood is a little hollowed out, and a calabash of the size and
shape of a deep tea-cup is fixed. This arrangement is repeated, so that
as many as twenty calabashes may be seen on various parts of the same
trunk. When the lower part has been too much wounded to give space for
any fresh incisions, a rude scaffold is sometimes erected, and a new
series of notches made higher up. The balsam-gatherer goes from time to
time round the trees with a pair of bags of hide, slung over the back
of a donkey, and empties into them the contents of the calabashes. In
these bags the balsam is sent down to the ports where it is transferred
to the cylindrical tins in which it reaches Europe. The bleeding of
the trees goes on for at least eight months of the year, causing them
ultimately to become much exhausted, and thin in foliage.

In some districts, as we learn from another traveller, it is customary
to let the balsam flow down the trunk into a receptacle at its base,
formed of the large leaf of a species of _Calathea_.

[794] _Journ. of the R. Hort. Soc._, May 1864; _Pharm. Journ._ vi.
(1865) 60.

From the observations of Mr. Weir, it appears that the balsam tree is
plentifully scattered throughout the Montaña around Plato and other
small ports on the right bank of the Magdalena. He states that he saw
at least 1,500 lb. of the drug on its way for exportation. From another
source, we know that it is largely collected in the valley of the
Sinu, and in the forests lying between that river and Cauca. None is
collected in Venezuela.

=Description=—Balsam of Tolu freshly imported is a light brown,
slow-flowing resin, soft enough to be impressible with the finger,
but viscid on the surface.[795] By keeping, it gradually hardens so
as to be brittle in cold weather, but it is easily softened by the
warmth of the hand. Thin layers show it to be quite transparent and
of a yellowish brown hue. It has a very agreeable and delicate odour,
suggestive of benzoin or vanilla, especially perceptible when the resin
is warmed, or when its solution in spirit is allowed to evaporate
on paper. Its taste is slightly aromatic with a barely perceptible
acidity, though its alcoholic solution decidedly reddens litmus.

In very old specimens, such as those which during the last century
reached Europe in little calabashes[796] of the size and shape of an
orange, the balsam is brittle and pulverulent, and exhibits when broken
a sparkling, crystalline surface. This old balsam is of a fine deep
amber tint and superior fragrance.

When Balsam of Tolu is pressed between two warmed plates of glass so
as to obtain it in a thin even layer, and then examined with a lens,
it exhibits an abundance of crystals of cinnamic acid. Balsam of Tolu
dissolves easily and completely in glacial acetic acid, acetone,
alcohol, chloroform or solution of caustic potash; it is less soluble
in ether, scarcely at all in volatile oils, and not in benzol or
bisulphide of carbon. The solution in acetone is devoid of rotatory
power in polarized light.

=Chemical Composition=—The balsam consists partly of an _amorphous
resin_, not soluble in bisulphide of carbon, which is supposed to be
the same as the dark resin precipitated by the bisulphide from balsam
of Peru. Scharling (1856) assigned the formula C₁₈H₂₀O₅ to that part of
the balsam which is soluble in potash.

If Tolu balsam is boiled with water, it yields to it cinnamic and
benzoic acid, which we have (1877) perfectly succeeded in separating by
repeated recrystallization from water; we have before us good specimens
of either, showing not only different melting points (133° C. and 121°
C.), but as to our crystals of benzoïc acid, isolated from the balsam
as stated above, we find that they also do _not_ evolve bitter almond
oil when mixed with sulphuric acid and chromate of potassium. The acids
may also be removed by boiling bisulphide of carbon.

Busse[797] showed that _benzylic_ ethers of both benzoic and cinnamic
acid are also constituents of the balsam, the cinnamate of benzyl being
present in larger quantity.

Upon distilling the balsam with water, it affords 1 per cent. of
_Tolene_, C₁₀H₁₆, boiling at about 170° C. This liquid rapidly absorbs
oxygen from the air. By destructive distillation, the balsam affords
the same substances as those obtainable from balsam of Peru, among
which _Phenol_ and _Styrol_ have been observed.

[795] I have seen it imported very fluid into London by way of New
York.—Sept. 1878.—F. A. F.

[796] The gourds, “Kürbsen,” of the list of Basle of 1647.

[797] _Berichte der Deutschen Chemischen Gesellschaft_, 1876. 833.

=Commerce=—The balsam is exported from New Granada, packed in
cylindrical tins holding about 10 lb. each. The quantity shipped from
Santa Marta in 1870 was 2,002 lb.; in 1871, 2,183 lb.; in 1872, 1,206
lb. In 1876 from the port of Savanilla 27,180 kilogrammes are stated to
have been exported.

=Uses=—Balsam of Tolu has no important medicinal properties. It is
chiefly used as an ingredient in a pleasant-tasting syrup and in
lozenges.

=Adulteration=—We have twice met with spurious Balsam of Tolu, but in
neither instance did the fraudulent drug bear any great resemblance to
the genuine.

Colophony, which might be mixed with the balsam, can be detected by
warm bisulphide of carbon which dissolves it, but removes from the pure
drug almost exclusively cinnamic and benzoic acid.


BALSAMUM PERUVIANUM.

_Balsam umindicum nigrum_; _Balsam of Peru_; F. _Baume de Pérou, Baume
de San Salvador_; G. _Perubalsam_.

=Botanical Origin=—_Myroxylon Pereiræ_ Klotzsch (_Myrospermum Pereiræ_
Royle), a tree attaining a height of about 50 feet, and throwing out
spreading, ascending branches at 6 to 10 feet from the ground.[798]

It is found in a small district of the State of Salvador in Central
America (formerly part of Guatemala), lying between 13°·35 and 14°·10
N. lat., and 89° and 89°·40 W. long., and known as the _Costa del
Balsamo_ or Balsam Coast. The trees grow naturally in the dense
forests; those from which the balsam is obtained are, if in groups,
sometimes enclosed, in other cases only marked, but all have their
distinct owners. They are occasionally rented for a term of years, or a
contract is made for the produce of a certain number.

The principal towns and villages around which balsam is produced, are
the following:—Juisnagua, Tepecoyo or Coyo, Tamanique, Chiltiuapan,
Talnique, Jicalapa, Teotepeque, Comasagua and Jayaque. All the lands on
the Balsam Coast are _Indian Reservation Lands_.

The Balsam of Peru tree was introduced in 1861 into Ceylon, where it
flourishes with extraordinary vigour.

[798] We are not yet prepared to accept the opinion of Baillon, that
_M. Pereiræ_ is specifically identical with _M. Toluifera_, though we
admit they are very closely related. According to our observations, the
two trees exhibit the following differences:—

           _M. Toluifera._       |    _M. Pereiræ._
                                 |
    Trunk tall and bare,         | Trunk throwing off
    branching at 40 to 60 feet   | ascending branches
    from the ground, and forming | at 6 to 10 feet from
    a roundish crown of foliage. | the ground.
                                 |
    Calyx rather tubular.        |  Calyx widely cup-shaped, shallow.
                                 |
    Racemes dense,               |  Racemes loose,
    3 to 4½ inches long.         |  6 to 7 inches long.
                                 |
    Legume scarcely narrowed     |  Legume much narrowed
    towards the  stalk-end.      |  towards the stalk-end.

See also Bentley and Trimen, _Medicinal Plants_, part 10 (1876),
_Toluifera Pereiræ_.

=History=—As in the case of Balsam of Tolu, it is to Monardes of
Seville that we are indebted for the earliest description of the drug
under notice. In a chapter headed _Del Balsamo_,[799] he states that
at the time he wrote (1565) the drug was not new, for that it had been
received into medicine immediately after the discovery of New Spain. As
the conquest of Guatemala took place about 1524, we may conclude that
the balsam was introduced into Europe soon afterwards.

Monardes further adds, that the balsam was in such high estimation
that it sold for 10 to 20 ducats (£4 10_s._ to £9) the ounce; and that
when taken to Rome, it fetched even 100 ducats for the same quantity.
The inducement of such enormous prices brought plenty of the drug to
Europe, and its value, as well as its reputation, was speedily reduced.

The description given by Monardes of extracting the balsam by boiling
the chopped wood of the trunk and branches, raises a doubt as to
whether the drug he had in view was exactly that now known; but he
never was in America, and may have been misinformed. Evidence that
our drug was in use, is afforded by Diego Garcia de Palacio, who, in
his capacity of Auditor of the Royal Audiencia of Guatemala, wrote
an account to Philip II., king of Spain, describing the geography
and productions of this portion of his majesty’s dominions. In this
interesting document, which bears date 1576 and has only recently been
published,[800] Palacio tells the king of the great balsam trees of
Guaymoco and of the coasts of Tonala,[801] and of the Indian method of
promoting the exudation of the balsam by scorching the trunk of the
tree. Prior to the conquest of the country by the Spaniards and for a
short time after, balsam formed part of the tribute paid to the Indian
chiefs of Cuscatlan, to whom it was presented in curiously ornamented
earthen jars.

The idea of great virtues attaching to the balsam is shown by the fact
that, in consequence of representations made by missionary priests in
Central America, Pope Pius V. granted a faculty to the Bishops of the
Indies, permitting the substitution of the balsam of Guatemala for that
of Egypt, in the preparation of the chrism used in the Roman Catholic
Church. This document, bearing date August 2, 1571, is still preserved
in the archives of Guatemala.[802]

In the 16th century, the balsam tree grew in the warm regions of Panuco
and Chiapan in Mexico, whence it was introduced into the famous gardens
of Hoaxtepec near the city of Mexico, described by Cortes in his letter
to Charles V. in 1552.[803]

A rude figure of the tree, certainly a _Myroxylon_ and probably the
species under notice, was published in the _Thesaurus Rerum Medicarum
Novæ Hispaniæ_ of Hernandez,[804] who also says that it had been
transferred to the “Hoaxtepecences hortos” of the Mexican kings
“delitiarum et magnificentiæ gratia.”

[799] Occurring in the first book of the work quoted in the Appendix,
which was published separately at Seville in 1565.

[800] Squier, _Documents and Relations concerning the Discovery and
Conquest of America_, New York, 1859.—Frantzius, _San Salvador und
Honduras im Jahre_ 1576. Berlin, 1873.

[801] The ancient name of the Balsam Coast; Guaymoco is a village
between Sonsonate and San Salvador. The pillars of wood of _Myroxylon_
in the church are, perhaps, says Squier, the very same as those
mentioned with admiration by Palacio.

[802] It may be found _in extenso_ in the original Latin in _Pharm.
Journ._ ii. (1861) 447 as well as in Hanbury’s _Science Papers_, 1876.
294.

[803] Clavigero, _Hist. of Mexico_, English trans. i. (1787) pp. 32.
379.

[804] Rome, 1628; 2nd ed. 1651. fol. 51; the book written in the town
of Mexico, bears at the same time also the title given in the Appendix.

Balsam of Peru was well known in German pharmacy in the beginning of
the 17th century (see article _Balsamum Tolutanum_).

The exports of Guatemala being shipped chiefly at Acajutla, were
formerly carried to Callao, the port of Lima, whence they were
transmitted to Spain. This circumstance led to the balsam acquiring
the misleading name of _Peru_, and in part to the notion that it was a
production of South America.

The history of Balsam of Peru was much amplified by a communication
of the late Dr. Charles Dorat, of Sonsonate, Salvador, in 1860 to
the _American Journal of Pharmacy_, and by still further information
accompanied by drawings and specimens, transmitted to one of us in
1863.[805] These statements have lastly been confirmed again on the
spot by Mr. Theophilus Wyss, a Swiss apothecary, established in San
Miguel la Union, San Salvador.[806]

=Extraction of the Balsam=—Early in November or December, or after the
last rains, the stems of the balsam trees are beaten with the back of
an axe, a hammer or other blunt instrument, on four sides, a similar
extent of bark being left unbruised between the parts that are beaten.
The bark thus injured soon cracks in long strips, and may be easily
pulled off. It is sticky as well as the surface below it, and there is
a slight exudation of fragrant resin, but not in sufficient quantity to
be worth collecting. To promote an abundant flow, it is customary, five
or six days after the beating, to apply lighted torches or bundles of
burning wood to the injured bark, whereby the latter becomes charred.
About a week later, the bark either drops or is taken off, and the stem
commences to exude the balsam. This is collected by placing rags (of
any kind or colour), so as entirely to cover the bare wood. As these
rags in the course of some days become saturated with the exudation,
they are collected, thrown into an earthen vessel of water, and
gently boiled and stirred until they appear nearly clean, the balsam
separating and sinking to the bottom. This process goes on for some
hours, the exhausted rags being from time to time taken out, and fresh
ones thrown in. As the rags are removed they are wrung out in a sort
of rope bag, and the balsam so saved is added to the stock. When the
boiler has cooled, the water is decanted, and the balsam is poured into
_tecomates_ or gourds, ready for the market.

The balsam prepared by means of rags is termed “balsamo de trapo;” a
little balsam of inferior quality is also produced, according to Wyss,
by boiling the bark with water. This method affords “Tacuasonte” or
“balsamo de cascara,” which is sometimes mixed with the balsamo de
trapo. Tacuasonte means prepared without fire.

[805] Hanbury in _Pharm. Journ._ v. (1864) 241. 315; also _Science
Papers_, 294-309.

[806] See my paper, with map, in _Schweizerische Wochenschrift für
Pharmacie_, 1878. 219 (Library of the Pharm. Soc., London).—In the
Catalogue of the contributions of San Salvador to the Paris exhibition,
p. 33, Dr. D. J. Guzman gives: “Détails sur le moyen, d’extraire
et travailler le _Balsamo negro_ du Salvador,” which are far from
satisfactory.—F. A. F.

The Indians work a tree a second year, by bruising the bark that was
left untouched the previous year. As the bark is said to be renewed in
the short space of two years, it is possible to obtain from the same
tree an annual yield of about 2 lb. of balsam for many years, provided
a few years of rest be occasionally allowed. Clay or earth is sometimes
smeared over the bare wood.

The trees sometimes exude spontaneously a greenish gum-resin of
slightly bitter taste, but totally devoid of balsamic odour. It has
been analyzed by Attfield (see opposite page).

=Secretion of the Balsam=—No observations have yet been made as to the
secretion of the balsam in the wood, or the part that is played by the
operation of scorching the bark. Neither the unscorched bark nor the
wood, as we have received them, possess any aromatic odour.

The old accounts speak of a very fragrant resin, far more valuable
than the ordinary balsam, obtained by incisions. We have made many
inquiries for it, but without the least success. Such a resin is easily
obtainable from the trunk of _M. Toluifera_.

=Description=—Balsam of Peru is a liquid having the appearance of
molasses, but rather less viscid. In bulk it appears black, but when
examined in a thin layer, it is seen to be of a deep orange-brown and
perfectly transparent. It has a balsamic, rather smoky odour, which is
fragrant and agreeable when the liquid is smeared on paper and warmed.
It does not much affect the palate, but leaves a disagreeable burning
sensation in the fauces.

The balsam has a sp. gr. of 1·15 to 1·16. It may be exposed to the air
for years without undergoing alteration or depositing crystals. It is
not soluble in water, but yields to it a little cinnamic and traces of
benzoic acid; from 6 to 8 parts of crystallized carbonate of sodium are
required to neutralize 100 parts of the balsam. It is but partially
and to a small extent dissolved by dilute alcohol, benzol, ether or
essential or fatty oils, not at all by petroleum ether. The balsam
mixes readily with glacial acetic acid, anhydrous acetone, absolute
alcohol or chloroform. Its rotatory power is very insignificant.

=Chemical Composition=—The peculiar process by which balsam of Peru is
obtained, causes it to contain a variety of substances not found in
the more natural resin of _Myroxylon Toluifera_; hence the two drugs,
though derived from plants most closely allied, possess very different
properties.

Three parts of the balsam mix readily with one part of bisulphide of
carbon, yet a further addition of the latter will cause the separation
of a brown flocculent resin. If the balsam be mixed with thrice
its weight of bisulphide, a coherent mass of dark resin, sometimes
amounting to about 38 per cent. of the balsam, is precipitated. The
bisulphide of carbon forms then a perfectly transparent brown liquid.
If this solution is shaken with water, the latter removes _Cinnamic_
and _Benzoic_ acids. To separate them, ammonia is cautiously added,
yet not in excess.[807] The solution of cinnamate and benzoate thus
obtained and duly concentrated, yields both these acids in white
crystals on addition of acetic or hydrochloric acid.

[807] By saturating the acid aqueous liquid with ammonia, it assumes a
transient bright yellow hue; an excess of ammonia transforms the whole
mixture into an emulsion, from which the cinnameïn again separates but
imperfectly.

The resin separated by means of bisulphide of carbon as above stated,
is a black brittle amorphous mass, having no longer the specific odour
of the balsam. It is soluble in caustic alkalis, also in alcohol; the
solution in the latter which may be considerably purified by charcoal,
reddens litmus, and is abundantly precipitated by an alcoholic solution
of neutral acetate of lead. Kachler (1869) by melting this resin with
potash obtained about ⅔ of its weight of protocatechuic acid.[808] By
destructive distillation, it furnishes benzoic acid, styrol, C₈H₈, and
toluol, C₇H₈.

As to the solution obtained with bisulphide of carbon, it forms, after
the bisulphide has evaporated, a brownish aromatic liquid of about
1·1 sp. gr., termed _Cinnameïn_. This substance may also be obtained
by distillation, yet less easily, on account of its very high boiling
point, about 300° C.

Cinnameïn, C₁₆H₁₄O₂, is resolved by concentrated caustic lye into
benzylic alcohol, C₇H₁₄O₂, and cinnamic acid, C₉H₈O₂, whence it follows
that cinnameïn is _Benzylic Cinnamate_. This is, according to Kraut
(1858, 1869, 1870) and to Kachler (1869, 1870), the chief constituent
of the balsam. The former chemist obtained from it nearly 60 per cent.
cinnameïn. Kachler assigns to the balsam the following composition: 46
per cent. of cinnamic acid, 32 of resin, 20 of benzylic alcohol. These
latter figures however are not quite consistent: 46 parts of cinnamic
acid (molecular weight = 148) would answer to 73 parts of benzylic
cinnamate; and 20 parts of benzylic alcohol require on the other hand
only (mol. weight = 108) 27·4 parts of cinnamic acid in order to form
benzylic cinnamate (mol. = 238).

Benzylic cinnamate, prepared as above stated, is a thick liquid,
miscible both with ether or alcohol, not concreting at -12° C., boiling
at 305° C., yet under ordinary circumstances not without decomposition.
By exposure to air, it slowly acquires an acid reaction; by prolonged
action of potash, especially in an alcoholic solution, toluol is
also formed. In this process, cinnamate of potassium finally forms a
crystalline mass, while an oily mixture of benzylic alcohol and toluol,
the so-called “_Peruvin_” constitutes the liquid part of the whole.

Grimaux (1868) has artificially prepared benzylic cinnamate by heating
an alkaline cinnamate with benzylic chloride. Thus obtained, that
substance forms crystals, which melt at 39° C., and boil at 225 to 235°
C. They consequently differ much from cinnameïn.

Delafontaine (1868) is of the opinion, that cinnameïn contains besides
benzylic cinnamate, cinnamylic cinnamate, C₃₆H₃₂O₄, the same substance
as described under the name of styracin in the article _Styrax
liquida_. He states that he obtained benzylic and cinnamylic alcohol
when he decomposed cinnameïn by an alkali. The two alcohols however
were separated only by fractional distillation.

From the preceding investigations it must be concluded, that the bark
of the tree contains resin and probably benzylic cinnamate. The latter
is no doubt altered by the process of collecting the balsam, which is
followed on the Balsam Coast. To this are probably due the free acids
in the balsam and its dark colour.

Another point of considerable interest is the fact, that the tree
exudes a gum-resin, containing according to Attfield 77·4 per cent.
of resin,[809] which is non-aromatic and devoid of cinnamic acid, and
therefore entirely distinct from balsam of Peru. The leaves of the tree
contain a fragrant oil.

[808] Numerous resins as benzoin, guaiacum, dragon’s blood, myrrh,
etc., and many other substances are capable of affording the same acid.

[809] _Pharm. Journ._ v. (1864) 248.

=Commerce=—The balsam is shipped chiefly at Acajutla. It used formerly
to be packed in large earthenware jars, said to be Spanish wine-jars,
which, wrapped in straw, were sewed up in raw hide. These packages have
of late been superseded by metallic drums, which have the advantage
of being much less liable to breakage. We have no exact statistics as
to the quantity exported from Central America. In the catalogue of
San Salvador (quoted above, page 207, note 2) p. 39, the value of the
balsam exported in 1876 from that country is stated to have been 78,189
dollars. The value of tobacco amounted to 69,717 dollars, that of
coffee to 1⅓ millions of dollars, indigo to 2¼ millions.

=Uses=—Occasionally prescribed in the form of ointment as a stimulating
application to old sores, sometimes internally for the relief of asthma
and chronic cough. It is said to be also employed for scenting soap.

=Adulteration=—We have before us a sample of an adulterated balsam,
which, we are told, is largely prepared at Bremen. It is less aromatic,
less rich in acids, and contains usually much less than 38 per cent. of
resin separable, as above stated, by means of bisulphide of carbon. At
first sight however the adulterated drug is not so easily recognized.

Other sorts of Balsam of Peru.

The value anciently set upon balsam for religions and medicinal uses,
led to its being extracted from the pods and also from trees no longer
employed for the purpose; and many of the products so obtained have
attracted the attention of pharmacologists.[810] Parkinson writing in
1640 observes that—“there have been divers other sorts of liquours,
called _Balsamum_ for their excellent vertues, brought out of the West
Indies, every one of which for a time after their first bringing was of
great account with all men and bought at great prices, but as greater
store was brought, so did the prices diminish and the use decay ...”

In Salvador, the name _Balsamo blanco_ (White Balsam) is applied to the
soft resin contained in the large ducts of the legume of _Myroxylon
Pereiræ_. This, when pressed out, forms a golden yellow, semi-fluid,
granular, crystalline mass, hardening by age, having a rather
unpleasant odour suggestive of melilot. Stenhouse (1850) obtained from
it the neutral resin _Myroxocarpin_, C₂₄H₃₄O₃, in thin colourless
prisms, an inch or more in length. We have succeeded in extracting
it directly from the pods. This White Balsam, which is distinctly
mentioned in the letter of Palacio in 1576 (see p. 206), is a scarce
and valuable article, never prepared for the market. A large jar of it
was sent to Pereira in 1850;[811] Guzman[812] and Wyss state that it is
known in the country as “Balsamito,” or “Balsamo _catolico_ or Virgin
Balsam.”

[810] Guibourt, _Hist. des Drog._ iii. (1850) 440.

[811] _Pharm. Journ._ x. (1851) 286.

[812] In the Catalogue alluded to, page 207, note 2.

A fragrant balsamic resin is collected, though in but very small
quantity, from _Myroxylon peruiferum_ Linn. f., a noble tree of New
Granada, Ecuador, Peru, Bolivia, and Brazil. A fine sample of this
substance, accompanied by herbarium and other specimens, was presented
to one of us (H.) by Mr. J. Correa de Méllo of Campinas (Brazil); it is
a resin having a general resemblance to Balsam of Tolu, but of somewhat
deeper and redder tint, and greater hardness. Pressed between two slips
of warmed glass, it does not exhibit any crystals.

In a treatise on Brazil written by a Portuguese friar about
1570-1600,[813] mention is made of the “_Cabueriba_” (_Cabure-iba_),
from which a much-esteemed balsam was obtained by making incisions in
the stem, and absorbing the exudation with cotton wool, somewhat in the
same way as Balsam of Peru is now collected in Salvador. This tree is
_Myrocarpus frondosus_ Allem., now called _Cabriuva preta_. The genus
is closely allied to _Myroxylon_.

Another fragrant oleo-resin, which has doubtless been confounded with
that of a _Myroxylon_, is obtained in Central America from _Liquidambar
styraciflua_ L., either by incision or by boiling the bark.


SEMEN BONDUCELLÆ.

_Semen Guilandinæ_; _Bonduc Seeds_, _Grey Nicker Seeds or Nuts_; F.
_Graines de Bonduc ou du Cniquier_, _Pois Quéniques_, _Pois Guénic_.

=Botanical Origin=—_Cæsalpinia Bonducella_ Roxb. (_Guilandina
Bonducella_ L.), a prickly, pubescent, climbing shrub[814] of wide
distribution, occurring in Tropical Asia, Africa and America,
especially near the sea. The compressed, ovate, spiny legume is 2 to 3
inches long, and contains one or two, occasionally three or four, hard,
grey, globular seeds.

The plant is often confounded with _C. Bonduc_ Roxb., a nearly allied
but much rarer species, distinguished by being nearly glabrous, having
leaflets very unequal at the base, no stipules, erect bracts, and
yellow seeds.

=History=—“_Pūti-Karanja_” stinking Karanja, in Susruta (I.223,
1) is the plant under notice. The word _Bunduk_, occurring in the
writings of the Arabian and Persian physicians, also in Constantinus
Africanus, mostly signifies _hazel-nut_.[815] One of these authors, Ibn
Baytar,[816] who flourished in the 13th century, further distinguished
a drug called _Bunduk Hindi_ (Indian hazel-nut), giving a description
which indicates it plainly as the seed under notice. Both _Bunduk_
and _Bunduk Hindi_ are enumerated in the list of drugs of Noureddeen
Mohammed Abdullah Shirāzy,[817] physician to the Mogul emperor Shah
Jehan, A.D. 1628-1661.

The pods of _C. Bonducella_ were figured by Clusius in 1605, under
the name of _Lobus echinodes_, and the plant both by Rheede[818] and
Rumphius. Piso and Marcgraf (1648) noticed it in Brazil and gave some
account of it with a bad woodcut, under the designation of _Inimbóy_
(now _Inimboja_), or in Portuguese _Silva do Praya_.

[813] Purchas, _His Pilgrimes_, iv. (1625) 1308.

[814] Fig. in Bentley and Trimem, _Med. Plants_, part 24 (1877).

[815] The word also means _a little ball_ or _a round stone_. Bunduk
Hindi is frequently used by Arabic authors to denote also Areca nut.

[816] Sontheimer’s translation, i. 177.

[817] _Ulfaz Udwiyeh_, translated by Gladwin, 1793. No. 543. 551.

[818] _Hort. Malab._ ii. (1679) tab. 22, sub nom. _Caretti_.

In recent times, Bonduc seeds have been employed on account of their
tonic and antiperiodic properties by numerous European practitioners in
the East, and have been included in the _Pharmacopœia of India_, 1868.

=Description=—The seeds are somewhat globular or ovoid, a little
compressed, ⁴/₁₀ to ⁸/₁₀ of an inch in diameter and weighing 20 to 40
grains. They are of a bluish or greenish grey tint, smooth, yet marked
by slightly elevated horizontal lines of a darker hue. The umbilicus
is surrounded by a small, dark brown, semilunar blotch opposite the
micropyle. The hard shell is from ¹/₂₅ to ²/₂₅ of an inch thick, and
contains a white kernel; representing from 40 to 50 per cent. of the
weight of the seed. It separates easily from the shell, and consists of
the two cotyledons and a stout radicle. When a seed is soaked for some
hours in cold water, a very thin layer can be peeled from the surface
of the testa. The kernel is bitter, but with the taste that is common
to most seeds of the family _Leguminosæ_.

=Microscopic Structure=—The outer layer of the testa, the epidermis
above alluded to, is composed of two zones of perpendicular, closely
packed cells, the outer measuring about 130 mkm., the inner 100 mkm. in
length and only 5 to 7 mkm. in diameter. The walls of these cylindrical
cells are thickened by secondary deposits, which in transverse section
show usually four or more channels running down nearly perpendicularly
through the whole cell.

The spongy parenchyme, which is covered by this very distinct outer
layer, is made up of irregular, ovate, subglobular or somewhat
elongated cells with large spaces between them, loaded with brown
masses of tannic matter, assuming a blackish hue when touched with
perchloride of iron. The thick walls of these cells frequently exhibit,
chiefly in the inner layers, undulated outlines. The tissue of the
cotyledons is composed of very large cells, swelling considerably in
water, and containing some mucilage (as may be ascertained when thin
slices are examined in oil), small starch granules, fatty oil, and a
little albuminous matter.

=Chemical Composition=—According to the medical reports alluded to in
the _Pharmacopœia of India_ (1868), Bonduc seeds, and still more the
root of the plant, act as a powerful antiperiodic and tonic.

The active principle has not yet been adequately examined. It may
perhaps occur in larger proportion in the bark of the root, which
is said to be more efficacious than the seeds in the treatment of
intermittent fever.[819]

In order to ascertain the chemical nature of the principle of the
seeds, one ounce of the kernels[820] was powdered and exhausted with
slightly acidulated alcohol. The solution after the evaporation of the
alcohol was made alkaline with caustic potash, which did not produce a
precipitate. Ether now shaken with the liquid, completely removed the
bitter matter, and yielded it in the form of an amorphous white powder,
devoid of alkaline properties. It is sparingly soluble in water, but
readily in alcohol, forming intensely bitter solutions; an aqueous
solution is not precipitated by tannic acid. It produces a yellowish
or brownish solution with concentrated sulphuric acid, which acquires
subsequently a violent hue. Nitric acid is without manifest influence.
From these experiments, we may infer that the active principle of the
Bonduc seed is a bitter substance not possessing basic properties.

[819] Waring, _Bazaar Medicines_, Travancore, 1860. 18.

[820] Kindly furnished us by Dr. Waring.

=Uses=—The powdered kernels either _per se_, or mixed with black pepper
(_Pulvis Bonducellæ compositus_ Ph. Ind.), are employed in India
against intermittent fevers and as a general tonic.

The fatty oil of the seeds is sometimes extracted and used in India; it
was shown at the Madras Exhibitions of 1855 and 1857.


LIGNUM HÆMATOXYLI.

_Lignum Campechianum v. Campescanum_; _Logwood_, _Peachwood_; F. _Bois
de Campèche_, _Bois d’Inde_; G. _Campecheholz_, _Blauholz_.

=Botanical Origin=—_Hæmatoxylon campechianum_ L., a spreading tree[821]
of moderate size, seldom exceeding 40 feet in height, native of the
bay of Campeachy, Honduras and other parts of Central America. It
was introduced into Jamaica by Dr. Barham[822] in 1715, and is now
completely naturalized in that and other of the West Indian Islands.

=History=—Hernan Cortes in his letter to the Emperor Charles V., giving
an account of his expedition to Honduras in 1525,[823] refers to the
Indian towns of Xiculango and Tabasco as carrying on a trade in cacao,
cotton cloth, and _colours for dyeing_,—in which last phrase there may
be an allusion to logwood. We have sought for some more definite notice
of the wood in the _Historia de las Indias_ of Oviedo,[824] the first
chronicler of America, but without much success.

Yet the wood must have been introduced into England in the latter
half of the 16th century, for, in 1581, an Act of Parliament[825]
was passed, abolishing its use and ordering that any found should be
forfeited and burned. In this Act the obnoxious dye is described as “a
certain kind of ware or stuff called _Logwood_ alias _Blockwood_ ... of
late years ... brought into this realm of England.” The object of this
measure was to protect the public against the bad work of the dyers,
who, it seems, were unable at that period to obtain durable colours by
the use of logwood. Eighty years later the art of dyeing had so far
improved that logwood was again permitted,[826] the colours produced by
it being declared as lasting and serviceable as those made by any other
sort of dyewood whatsoever.

The wood is mentioned by De Laet (1633) as deriving its name from the
town of Campeachy, whence, says he, it is brought in great plenty to
Europe.[827]

[821] Fig. in Bentley and Trimen, _Med. Plants_, part 5 (1876).

[822] _Hortus Americanus_, Kingston, Jamaica, 1794. 91.

[823] _Fifth Letter of Hernan Cortes to the Emperor Charles V._, Lond.
(Hakluyt Society) 1868. 43.

[824] The first edition bears date 1535. We have used the modern one of
Madrid, 1851-55, 4to., and may refer in particular to tom. i. lib. ix.
c. 15, iii. lib. xxxi. c. 8 and c. 11.—See Appendix: Fernandez.

[825] 23 Eliz. c. 9.

[826] 13-14 Car. ii. c. 11. sect. 26 (A.D. 1662), by which the Act of
Elizabeth was repealed.

[827] _Novus Orbis_, 1633. 274 and 265.

As a medicine, logwood was not employed until shortly before the year
1746, when it was introduced into the London Pharmacopœia under the
name of _Lignum tinctile Campechense_.

=Description=—The tree is fit to be felled when about ten years old;
the dark bark and the yellowish sapwood are chipped off, the stems
cut into logs about three feet long, and the red heartwood alone
exported. By exposure to air and moisture, the wood acquires externally
a blackish-red colour; internally it remains brownish red. It splits
well, although of a rather dense and tough texture.

The transverse section of a piece of logwood exhibits to the naked eye
a series of very narrow concentric zones, formed by comparatively large
pores, and of small parenchymatous circles separated by the larger and
darker rings of the proper woody tissue. The numerous medullary rays
are visible only by means of a lens. The wood has a pleasant odour.

For use in pharmacy, logwood is always purchased in the form of chips,
which are produced by the aid of powerful machinery. The chips have a
feeble, seaweed-like odour, and a slightly sweet, astringent taste,
better perceived in a watery decoction than by chewing the dry wood,
which however quickly imparts to the saliva its brilliant colour.

=Microscopic Structure=—Under a high magnifying power, the concentric
zones are seen to run not quite regularly round the centre, but in a
somewhat undulating manner, because they do not correspond, as in our
indigenous woods, to regular periods of annual growth. The vascular
bundles contain only a few vessels, and are transversely united by
small lighter parenchymatous bands. The latter are made up of large,
cubic, elongated or polygonal cells, each loaded with a crystal of
oxalate of calcium. The large punctuated vessels having frequently
150 mkm. diameter, are surrounded by this woody parenchyme, while
the prevailing tissue of the wood is composed of densely packed
prosenchyme, consisting of long cylindrical cells (_libriform_) with
thick, dark red-brown walls having small pores.

The medullary rays are of the usual structural character, running
transversely in one to three straight rows; in a longitudinal
section, the single rays show from 4 to 40 rows succeeding each other
perpendicularly. No regular arrangement of the rays is obvious in a
longitudinal section made in a tangential direction. The colouring
matter is chiefly contained in the walls of the ligneous tissue and the
vessels, and sometimes occurs in crystals of a greenish hue within the
latter, or in clefts of the wood.

=Chemical Composition=—Logwood was submitted to analysis by Chevreul as
early as the year 1810,[828] since which period all contributions to
a knowledge of the drug refer exclusively to its colouring principle
_Hæmatoxylin_, which Chevreul obtained in a crystallized state and
called _Hématine_. The very interesting properties of this substance
have been chiefly examined by Erdmann (1842) and by O. Hesse (1858-59).

[828] _Annals de Chimie_, lxxxi. (1812) 128.

Erdmann obtained from logwood 9 to 12 per cent. of crystallized
hæmatoxylin, which he showed to have the formula C₁₆H₁₄O₆. In a pure
state it is colourless, crystallizing with 1 or with 3 equivalents
of water, and is readily soluble in hot water or in alcohol, but
sparingly in cold water or in ether. It has a persistent sweet taste
like liquorice. The crystals of hæmatoxylin acquire a red colour by
the action of sunlight, as likewise their aqueous solution. They are
decomposed by ozone but not by pure and dry oxygen. In presence of
alkalis, hæmatoxylin exposed to the air quickly yields dark purplish
violet solutions, which soon acquire a yellowish or dingy brownish
colour; hence in analytical chemistry hæmatoxylin is used as a test for
alkalis.

By the combined action of ammonia and oxygen, dark violet crystalline
scales of _Hæmateïn_, C₁₆H₁₄O₆ + 3 OH₂, are produced.[829] They show a
fine green hue, which is also very commonly observable on the surface
of the logwood chips of commerce. Hæmateïn may again be transformed
into hæmatoxylin by means of hydrogen or of sulphurous acid.

Hæmatoxylin separates protoxide of copper from an alkaline solution
of the tartrate, and deviates the ray of polarized light to the right
hand. It is not decomposed by concentrated hydrochloric acid; by
melting hæmatoxylin with potash, pyrogallol (pyrogallic acid, C₆H₆O₃)
is obtained. Alum and the salts of lead throw down precipitates from
solutions of hæmatoxylin, the latter being of a bluish-black colour.
Logwood affords upon incineration 3·3 per cent. of ash.

The colouring matter being abundantly soluble in boiling water, an
_Extract of Logwood_ is also prepared on a large scale. It occurs in
commerce in the form of a blackish brittle mass, taking the form of
the wooden chest into which it is put while soft. The extract shares
the chemical properties of hæmatoxylin and hæmateïn: whether it also
contains gum requires investigation.

=Production and Commerce=—The felling and shipping of logwood in
Central America have been described by Morelet,[830] who states that in
the woods of Tabasco and Yucatan the trade is carried on in the most
irrational and reckless manner. By advancing money to the natives, or
by furnishing them with spirits, arms, or tools, the proprietors of
the woods engage them to fell a number of trees in proportion to their
debts. This is done in the dry season, the rainy period being taken
for the shipment of the logs, which are conveyed chiefly to the island
of Carmen in the Laguna de Terminos in South-western Yucatan, and to
Frontera on the mouths of the Tabasco river, at which places European
ships receive cargoes of the wood.

In 1877 the export of Laguna de Terminos amounted to 528,605 quintals
(one quintal = 46 kilogrammes), that from Port-au-Prince, Hayti, in
1872, nearly to 90,000 tons.

Four sorts of logwood are found in the London market, namely
_Campeachy_, quoted[831] at £8 10_s._ to £9 10_s._ per ton; _Honduras_,
£6 10_s._ to £6 15_s._; _St. Domingo_, £5 15_s._ to £6; _Jamaica_,
£5 2_s._ 6_d._ to £5 10_s._ The imports into the United Kingdom were
valued in 1872 at £233,035. The quantities imported during that and the
previous three years were as follows:—

        1869         1870          1871         1872
    50,458 tons.  62,187 tons.  39,346 tons.  46,039 tons.

[829] Benedikt, in 1875, assigned them the formula C₄₈H₃₉O₁₈N + 9 OH₂.

[830] _Voyage dans l’Amérique centrale, l’île de Cuba et le Yucatan_,
Paris, 1857.

[831] _Public Ledger_, 28 Feb. 1874.

In 1876 the import was 64,215 tons, valued at £415,857. The largest
quantity is supplied by the British West India Islands. Hamburg also
imports annually about 20,000 tons of logwood.

=Uses=—Logwood in the form of decoction is occasionally administered
in chronic diarrhœa, and especially in the diarrhœa of children. Cases
have occurred in which its use has been followed by phlebitis. Its
employment in the art of dyeing is far more important.

=Adulteration=—The woods of several species of _Cæsalpinia_ imported
under the name of _Brazil Wood_ and used for dyeing red, bear an
external resemblance to logwood, with which it is said they are
sometimes mixed in the form of chips. They contain a crystallizable
colouring principle called _Brasilin_, C₂₂H₂₀O₇, or, according to
Liebermann and Burg (1876), C₁₆H₁₄O₅, which affords with alkalis _red_
and not bluish or purplish solutions, and yields trinitrophenol,
C₆H₂(NO₂) 3OH (picric acid), when boiled with nitric acid, while
hæmatoxylin yields oxalic acid only. The best source for brasilin is
the wood of _Cæsalpinia Sappan_ L., a tree of the East Indies, well
known as _Bakam_, _Brazil Wood_, _Lignum Brasile_, _Verzino_ of the
Italians, an important object of commerce during the middle ages.[832]


FOLIA SENNÆ.

_Senna Leaves_; F. _Feuilles de Séné_; G. _Sennesblätter_.

=Botanical Origin=—The Senna Leaves of commerce are afforded by two
species of _Cassia_[833] belonging to that section of the genus which
is distinguished by having leaves without glands, axillary racemes
elongating as inflorescence advances, membranaceous bracts which in the
young raceme conceal the flower buds but drop off during flowering, and
a short, broad, flat legume.

The senna plants are low perennial bushy shrubs, 2 to 4 feet high,
having pari-pinnate leaves with leaflets unequal at the base, and
yellow flowers. The pods contain 6 or more seeds in each, suspended
on alternate valves by long capillary funicles. These run towards the
pointed end of the seed, but are curved at their attachment to the
hilum just below. The seeds are compressed and of an obovate-cuneate or
oblong form, beaked at the narrower end.[834]

The species in question are the following:—

1. _Cassia acutifolia_ Delile[835]—a shrub about 2 feet high, with
pale subterate or obtusely angled, erect or ascending branches,
occasionally slightly zigzag above, glabrous at least below. Leaves
usually 4-5-jugate; leaflets oval or lanceolate, acute, mucronate,
usually more or less distinctly puberulous or at length glabrous,
pale or subglaucous at least beneath, subsessile. Stipules subulate,
spreading or reflexed, 1-2 lines long. Racemes axilliary, erect, rather
laxly many-flowered, usually considerably exceeding the subtending
leaf. Bracts membranous, ovate or obovate, caducous. Pedicels at length
2-3 lines. Sepals obtuse, membranous. Two of the anterior anthers much
exceeding the rest of the fertile stamens. Legume flat, very broadly
oblong, but slightly curved upwards, obliquely stipitate, broadly
rounded at the extremity with a minute or obsolete mucro indicating the
position of the style on the upper edge; 1½-2¼ inches long, ¾-1 inch
broad; valves chartaceous, obsoletely or thinly puberulous, faintly
transverse-veined, unappendaged. Seeds obovate-cuneate, compressed;
cotyledons plane, extending the large diameter of the seed in
transverse section.[836]

[832] See Yule, _Marco Polo_, ii. (1874). 369.

[833] Some writers have removed these plants from _Cassia_ to a
separate genus named _Senna_, but such subdivision is repudiated by the
principal botanists. The intricate synonymy of the senna plants has
been well worked out by J. B. Batka in his memoir entitled _Monographie
der Cassien-Gruppe Senna_ (Prag, 1866), of which we have made free
use. We have also had the advantage of the recent _Revision of the
Genus Cassia_ by Bentham (_Linn. Trans._, xxvii. 1871. 503) and of
the labours of Oliver on the same subject in his _Flora of Tropical
Africa_, ii. (1871) 268-282.

[834] On the structure of the seed, see Batka, _Pharm. Journ._ ix.
(1850) 30.

[835] _Synonyms_—_C. Senna_ β. Linn.; _C. lanceolata_ Nectoux; _C.
lenitiva_ Bisch.; _Senna acutifolia_ Batka.

[836] We borrow the above description from Prof. Oliver.

The plant is a native of many districts of Nubia (as Sukkot, Mahas,
Dongola, Berber), Kordofan and Sennaar; grows also in Timbuktu and
Sokoto, and is the source of _Alexandrian Senna_.

2. _C. angustifolia_ Vahl[837]—This species is closely related to the
preceding, the general description of which is applicable to it with
the following exceptions. In the present plant the leaflets, which are
usually 5-8-jugate, are narrower, being oval-lanceolate, tapering from
the middle towards the apex; they are larger, being from one to nearly
2 inches long, and are either quite glabrous or furnished with a very
scanty pubescence. The legume is narrower (7-8 lines broad), with the
base of the style distinctly prominent on its upper edge.

The plant abounds in Yemen and Hadramaut in Southern Arabia; it is also
found on the Somali coast, in Sind and the Punjab. In some parts of
India it is now cultivated for medicinal use.

The uncultivated plant of Arabia supplies the so-called _Bombay Senna_
of commerce, the true _Senna Mekki_ of the East. The cultivated and
more luxuriant plant, raised originally from Arabian seeds, furnishes
the _Tinnevelly Senna_ of the drug market.

=History=—According to the elaborate researches of Carl Martius,[838] a
knowledge of senna cannot be traced back earlier than the time of the
Elder Serapion, who flourished in the 9th or 1Oth century; and it is
in fact to the Arabian physicians that the introduction of the drug to
Western Europe is due. Isaac Judæus,[839] who wrote probably about A.D.
850-900 and who was a native of Egypt, mentions senna, the best kind of
which he says is that brought from Mecca.

Senna (as _Ssinen_ or _Ssenen_) is enumerated among the commodities
liable to duty at Acre in Palestine at the close of the 12th
century.[840] In France in 1542, a pound of senna was valued in an
official tariff[841] at 15 sols, the same price as pepper or ginger.

The Arabian and the mediæval physicians of Europe used both the pods
and leaves, preferring however the former. The pods (_Folliculi Sennæ_)
are still employed in some countries.

[837] _Synonyms_—_C. lanceolata_ Roxb.; _C. elongata_ Lem. Lis.; _Senna
officinalis_ Roxb.; _S. angustifolia_ Batka.

[838] _Versuch einer Monographie der Sennesblätter_, Leipz. 1867.

[839] _Opera Omnia_, Lugd. 1515, lib. 2. Practices, c. 39.

[840] _Recueil des Historiens des Croisades, Lois_, ii. (1843) 177.

[841] Fontanon, _Edicts et Ordonnances des Roys de France_, éd. 2, ii.
(1585) 349.

_Cassia obovata_ Coll.[842] was the species first known to botanists,
and it was even cultivated in Italy for medicinal use during the first
half of the 16th century. Hence the term _Italian Senna_ used by
Gerarde and others. In the records of the “Cinque savii alla mercanzia”
at Venice we found an order bearing date 1526 to the effect that Senna
leaves of Tuscany were inadmissible; the same was applied in 1676 to
the drug from Tripoli in Barbaria, that from Cairo being exclusively
permitted.

=Production=—According to Nectoux,[843] whose observations relate to
Nubia at the close of the last century, the peasants make two senna
harvests annually, the first and more abundant being at the termination
of the rains,—that is in September; while the other, which in dry
seasons is almost _nil_, takes place in April.

The gathering consists in simply cutting down the shrubs, and exposing
them on the rocks to the burning sun till completely dry. The drug is
then packed in bags made of palm leaves holding about a quintal each,
and conveyed by camels to Es-souan and Darao, whence it is transported
by water to Cairo. By many travellers it is stated that _Senna jebeli_,
i.e. _mountain senna_ (_C. acutifolia_), finds its way to the ports of
Massowhah and Suakin, and thence to Cairo and Alexandria.

_Cassia obovata_, which is called by the Arabs _Senna baladi_, i.e.
_indigenous_ or _wild senna_, grows in the fields of durra (_Sorghum_)
at Karnak and Luxor, and in the time of Nectoux was held in such small
esteem that it fetched but a quarter the price of the _Senna jebeli_
brought by the caravans of Nubia and the Bisharrin Arabs. It is not now
collected.

=Description=—Three kinds of senna are distinguished in English
commerce:—

1. _Alexandrian Senna_—This is furnished by _Cassia acutifolia_ and
is imported in large bales. It used formerly always to arrive in a
very mixed and dirty state, containing, in addition to leaflets of
senna, a variable proportion of leafstalks and broken twigs, pods and
flowers; besides which there was almost invariably an accompaniment of
the leaves, flowers and fruits of _Solenostemma Argel_ Hayne (p. 220),
not to mention seeds, stones, dust and heterogeneous rubbish. Such a
drug required sifting, fanning and picking, by which most of these
impurities could be separated, leaving only the senna contaminated with
leaves of argel. But Alexandrian Senna has of late been shipped of much
better quality. Some we have recently seen (1872) was, as taken from
the original package, wholly composed of leaflets of _C. acutifolia_ in
a well-preserved condition; and even the lower qualities of senna are
never now contaminated with argel to the extent that was usual a few
years ago.

[842] It is a glaucous shrub with obovate leaflets, broadly rounded and
mucronulate, reniform legume terminated by persistent style, and marked
along the middle of each valve by a series of crest-shaped ridges
corresponding to the seeds. It is more widely distributed in the Nile
region than the other species, and is also found in Sindh and Gujerat
and (naturalized) in the West Indies. Its leaflets (also pods) may
occasionally be picked out of Alexandrian Senna.

[843] _Voyage dans la Haute Egypte ... avec des observations sur les
diverses espèces de Séné qui sont répandues dans le commerce_, Paris,
1808. fol.

The leaflets, the general form of which has already been described (p.
216), are ¾ to 1¼ inches long, rather stiff and brittle, generally a
little incurled at the edges, conspicuously veined, the midrib being
often brown. They are covered with a very short and fine pubescence
which is most dense on the midrib. The leaves have a peculiar opaque,
light yellowish green hue, a somewhat agreeable tea-like odour, and
a mucilaginous, not very marked taste, which however is sickly and
nauseous in a watery infusion.

2. _Arabian Moka, Bombay or East Indian Senna_—This drug is derived
from _Cassia angustifolia_, and is produced in Southern Arabia. It is
shipped from Moka, Aden and other Red Sea ports to Bombay, and thence
reaches Europe.

Arabian senna is usually collected and dried without care, and is
mostly an inferior commodity, fetching in London sometimes as low a
price as ½_d._ to ¼_d._ per lb. Yet so far as we have observed, it is
never adulterated, but consists wholly of senna leaflets, often brown
and decayed, mixed with flowers, pods, and stalks. The leaflets have
the form already described (p. 217); short adpressed hairs are often
visible on their under surface.

3. _Tinnevelly Senna_—Derived from the same species as the last, but
from the plant cultivated in India, and in a state of far greater
luxuriance than it exhibits in the drier regions of Arabia where
it grows wild. It is a very superior and carefully collected drug,
consisting wholly of the leaflets. These are lanceolate, 1 to 2 inches
in length, of a yellowish green on the upper side, of a duller tint on
the under, glabrous or thinly pubescent on the under side with short
adpressed hairs. The leaflets are less rigid in texture than those of
Alexandrian senna, and have a tea-like, rather fragrant smell, with but
little taste.

Tinnevelly senna has of late fallen off in size, and some importations
in 1873 were not distinguishable from Arabian senna, except from having
been more carefully prepared. The drug is generally shipped from
Tuticorin in the extreme south of India.

=Chemical Composition=—The analysis of senna with a view to the
isolation of its active principle has engaged the attention of numerous
chemists, but as yet the results of their labours are not quite
satisfactory.

Ludwig (1864) treated an alcoholic extract of senna with charcoal,
and obtained from the latter by means of boiling alcohol two bitter
principles, _Sennacrol_, soluble in ether, and _Sennapicrin_, not
dissolved by ether.

Dragendorff and Kubly (1866) have shown the active substance of senna
to be a colloid body, easily soluble in water but not in strong
alcohol. When a syrupy aqueous extract of senna is mixed with an equal
volume of alcohol, and the mucilage thus thrown down has been removed,
the addition of a further quantity of alcohol occasions the fall of
a dark brown, almost tasteless, easily alterable substance, which
is indued with purgative properties. It was further shown that this
precipitate was a mixture of calcium and magnesium salts of phosphoric
acid and a peculiar acid. The last named, separated by hydrochloric
acid, has been called _Cathartic Acid_; it is a black substance which
in the mouth is at first insipid, but afterwards tastes acid and
somewhat astringent. In water or strong alcohol it is almost insoluble,
and entirely so in ether or chloroform; but it dissolves in warm dilute
alcohol. From this solution it is precipitable by many acids, but not
by tannic.

Groves[844] in 1868, unaware of the researches of Dragendorff and
Kubly, arrived at similar results as these chemists, and proved
conclusively that a cathartate of ammonia possesses in a concentrated
form the purgative activity of the original drug.

The exactness of the chief facts relative to the solubility in
weak alcohol of the active principle of senna set forth by the
said chemists, was also remarkably supported by the long practical
experience of T. and H. Smith of Edinburgh.[845]

When cathartic acid is boiled with alcohol and hydrochloric acid, it is
resolved into sugar and _Cathartogenic Acid_.

The alcoholic solution from which the cathartates have been separated
contains a yellow colouring matter which was called _Chrysoretin_ by
Bley and Diesel (1849), but identified as _Chrysophan_[846] by Martius,
Batka and others. Dragendorff and Kubly regard the identity of the two
substances as doubtful.

The same alcoholic solution which contains the yellow colouring matter
just described, also holds dissolved a sugar which has been named
_Catharto-mannite_. It forms warty crystals, is not susceptible of
alcoholic fermentation, and does not reduce alkaline cupric tartrate.
The formula assigned to it is C₄₂H₄₄O₃₈.

Senna contains tartaric and oxalic acids with traces of malic acid.
The large amount of ash, 9 to 12 per cent., consisting of earthy and
alkaline carbonates, also indicates the presence of a considerable
quantity of organic acids.

=Commerce=—Alexandrian Senna, the produce of Nubia and the regions
further south, was formerly a monopoly of the Egyptian Government,
the enjoyment of which was granted to individuals in return for a
stipulated payment: hence it was known in continental trade as _Séné de
la palte_, while the depots were termed _paltes_ and those who farmed
the monopoly _paltiers_.[847] All this has long been abolished, and the
trade is now free, the drug being shipped from Alexandria.

Arabian senna is brought into commerce by way of Bombay. The quantity
of senna imported thither from the Red Sea and Aden in the year 1871-72
was 4,195 cwt., and the quantity exported during the same period, 2,180
cwt.[848]

=Uses=—Senna leaves are extensively employed in medicine as a purgative.

=Adulteration=—The principal contamination to which senna is at present
liable arises from the presence of the leaves of _Solenostemma Argel_
Hayne, a plant of the order _Asclepiadeæ_, 2 to 3 feet high, growing in
the arid valleys of Nubia. Whether these leaves are used for the direct
purpose of adulteration, or under the notion of _improving_ the drug,
or in virtue of some custom or prejudice, is not very evident. It is
certain however that druggists have been found who _preferred_ senna
that contained a good percentage of argel.

[844] _Pharm. Journ._ x. (1869) 196.

[845] _Ibid._ 315.

[846] See Art. _Radix Rhei_.

[847] From Italian _appaltare_, to let or farm.

[848] _Statement of the Trade and Navigation of the Presidency of
Bombay for_ 1871-72, pt. ii. 21. 98.

Nectoux, to whom we owe the first exact account of the argel or hárgel
plant,[849] describes it as never gathered with the senna by accident
or carelessness, but always separately. In fact he saw, both at Esneh
and Phile, the original bales of argel as well as those of senna: and
at Boulak near Cairo, at the beginning of the present century, the
argel used to be regularly mixed with senna in the proportion of one to
four.

The leaves of argel after a little practice are very easily recognized;
but their complete separation from senna by hand-picking is a tedious
operation. They are lanceolate, equal at the base, of the same size as
senna leaflets but often larger, of a pallid, opaque, greyish-green,
rigid, thick, rather crumpled, wrinkled and pubescent, not distinctly
veined. They have an unmistakeably bitter taste. The small, white,
star-like flowers, or more often the flower buds, in dense corymbs
are found in plenty in the bales of Alexandrian senna. The slender,
pear-shaped follicles, when mature 1½ inches long, with comose seeds
are less frequent. It has been shown by Christison[850] that argel
leaves administered _per se_ have but a feeble purgative action, though
they occasion griping. It is plain therefore that their admixture with
senna should be deprecated.

The leaves or leaflets of several other plants were formerly mixed
occasionally with senna, as those of the poisonous _Coriaria
myrtifolia_ L., a Mediterranean shrub, of _Colutea arborescens_ L., a
native of Central and Southern Europe, and of the Egyptian _Tephrosia
Apollinea_ Delile. We have never met with any of them.[851]


FRUCTUS CASSIÆ FISTULÆ.

_Cassia Fistula_; _Purging Cassia_; F. _Casse Canefice_, _Fruit du
Caneficer_; G. _Röhrencassie_.

=Botanical Origin=—_Cassia Fistula_ L. (_Cathartocarpus Fistula_
Pers., _Bactyrilobium Fistula_ Willd.) a tree indigenous to India,
ascending to 4000 feet in the outer Himalaya, but now cultivated or
subspontaneous in Egypt, Tropical Africa,[852] the West Indies and
Brazil. It is from 20 to 30 feet high (in Jamaica even 50 feet) and
bears long pendulous racemes of beautiful fragrant, yellow flowers.
Some botanists have established for this tree and its near allies a
separate genus, on account of its elongated, cylindrical indehiscent
legume, but by most it is retained in the genus _Cassia_.

[849] _Op. cit._ (See p. 218).

[850] _Dispensatory_, ed. 2. 1848. 850.

[851] The reader will find figures of these leaves contrasted with
Senna in Pereira’s _Elem. of Mat. Med._ ii. part ii (1853) 1866.

[852] Schweinfurth found it in 6° N. lat. and 28-29° E. long., in the
country of the Dor, where the tree may also be indigenous.

=History=—The name _Casia_ or _Cassia_ was originally applied
exclusively to a bark related to cinnamon which, when rolled into a
tube or pipe, was distinguished in Greek by the word σῦριγζ, and in
Latin by that of _fistula_. Thus Scribonius Largus,[853] a physician
of Rome during the reigns of Tiberius and Claudius, with the latter of
whom he is said to have visited Britain, A.D. 43, uses the expression
“_Casiæ rufæ fistularum_” in the receipt for a collyrium. Galen[854]
describing the different varieties of cassia, mentions that called
_Gizi_[855] (γίζεις) as being quite like cinnamon or even better; and
also names a well-known cheaper sort, having a strong taste and odour
which is called _fistula_, because it is rolled up like a tube.

Oribasius, physician to the Emperor Julian in the latter half of the
4th and beginning of the 5th century, describes _Cassia fistula_ as
a _bark_ of which there are several varieties, having pungent and
astringent properties (“_omnes cassiæ fistulæ vires habent acriter
exalfacientes et stringentes_”), and sometimes used in the place of
cinnamon.[856]

It is doubtless the same drug which is spoken of by Alexander
Trallianus[857] as Κασίας σῦριγζ (_casia fistula_) in connexion with
costus, pepper and other aromatics; and named by other Greek writers as
Κασία συριγγώδης (_casia fistularis_). Alexander still more distinctly
calls it also Κασία αἰγυπτία.[858]

The tree under examination and its fruit were exactly described in the
beginning of the 13th century by Abul Abbâs Annâbatî of Sevilla;[859]
the fruit, the Cassia Fistula of modern medicine, is noticed by Joannes
Actuarius, who flourished at Constantinople towards the close of the
13th century; and as he describes it with particular minuteness,[860]
it is evident that he did not consider it well known. The drug is also
mentioned by several writers of the school of Salernum. The tree would
appear to have found at an early period its way to America, if we are
correct in referring to it the Cassia Fistula enumerated by Petrus
Martyr among the valuable products of the New World.[861] The drug was
a familiar remedy in England in the time of Turner, 1568.[862]

The tree was figured in 1553 by the celebrated traveller Belon who met
with it in the gardens of Cairo, and in 1592 by Prosper Alpinus who
also saw it in Egypt.

=Description=—The ovary of the flower is one-celled with numerous
ovules, which as they advance towards maturity become separated by
the growth of intervening septa. The ripe legume is cylindrical, dark
chocolate-brown, 1½ to 2 feet long by ¾ to 1 inch in diameter, with
a strong short woody stalk, and a blunt end suddenly contracted into
a point. The fibro-vascular column of the stalk is divided into two
broad parallel seams, the dorsal and ventral sutures, running down
the whole length of the pod, The sutures are smooth, or slightly
striated longitudinally; one of them is formed of two ligneous bundles
coalescing by a narrow line. If the legume is curved, the ventral
suture commonly occupies its inner or concave side. The valves of the
pods are marked by slight transverse depressions (more evident in
small specimens) corresponding to the internal divisions, and also by
inconspicuous transverse veins.

[853] _Compositiones Medicamentorum_, cap. 4. sec. 36.

[854] _De Antidot._ i. c. 14.

[855] Noticed likewise among the commodities liable to duty at
Alexandria in the 2nd century.—Vincent, _Commerce of the Ancients_, ii.
712.

[856] _Physica Hildegardis_, Argent. 1533. 227.

[857] Libri xii. J. Guinterio interprete, Basil., 1556. lib. vii. c. 8.

[858] Puschmann’s edition (quoted in the appendix) i. 435.

[859] Meyer, _Geschichte der Botanik_, iii. (1856). 226.

[860] “Quemadmodum si ventrem mollire fuerit animus, pruna, et præcipué
Damascena adjicimus, atque quippiam feré nigræ nominatæ casiæ. Est
autem fructus ejus fistulus et oblongus, nigrum intus humorem concretum
gestans, qui haudquaquam una continuitate coaluit, sed ex intervallo
tenuibus lignosisque membranulis dirimitur, habens ad speciei
propagationem, grana quædam seminalia, siliquæ illi quæ nobis innotuit,
adsimilia.”—_Methodus Medendi_, lib. v. c. 2.

[861] _De nuper sub D. Carolo repertis insulis_, Basil. 1521.

[862] _Herball_, part. 3. 20.

Each of the 25 to 100 seeds which a legume contains, is lodged in a
cell formed by very thin woody dissepiments. The oval, flattish seed
from ³/₁₀ to ⁴/₁₀ of an inch long, of a reddish-brown colour, contains
a large embryo whose yellowish veined cotyledons cross diagonally, as
seen on transverse section, the horny white albumen. One side is marked
by a dark line (the raphe). A very slender funicle attaches the seed to
the ventral suture.

In addition to the seeds, the cells contain a soft saccharine pulp
which in the recent state fills them up, but in the imported pods
appears only as a thin layer, spread over the septum, of a dark viscid
substance of mawkish sweet taste. It is this pulp which is made use of
in pharmacy.

=Microscopic Structure=—The bands above described running along the
whole pod, are made up of strong fibro-vascular bundles mixed with
sclerenchymatous tissue. The valves consist of parenchymatous cells,
and the whole pod is coated with an epidermis exhibiting small tabular
cells, which are filled with dark granules of tannic matter. A few
stomata are also met with. The thin brittle septa of the pod are
composed of long ligneous cells, enclosing here and there crystals of
oxalate of calcium.

The pulp itself, examined under water, is seen to consist of loose
cells, not forming a coherent tissue. They enclose chiefly granules of
albuminoid matters and stellate crystals of oxalate of calcium. The
cell-wall assumes, on addition of iodine, a blue hue if they have been
previously washed by potash lye. The seeds are devoid of starch, but
yield a copious amount of thick mucilage, which surrounds them like a
halo if they are macerated in water.

=Chemical Composition=—No peculiar principle is known to exist either
in the woody or the pulpy portion of cassia fistula. The pulp contains
sugar in addition to the commonly occurring bodies noticed in the
previous section.

=Uses=—The pulp separated from the woody part of the pods by crushing
the latter, digesting them in hot water, and evaporating the strained
liquor, is a mild laxative in common domestic use in the South of
Europe,[863] but in England scarcely ever now administered except in
the form of the well-known _Lenitive Electuary_ (_Confectio sennæ_) of
which it is an ingredient.

=Commerce=—Cassia fistula is shipped to England from the East and
West Indies, but chiefly from the latter. The pulp _per se_ has been
occasionally imported, but it should never be employed when the legumes
for preparing it can be obtained.

=Substitutes=—The pods of some other species of _Cassia_ share the
structure above described and have been sometimes imported.

[863] Thus there were imported into Leghorn in 1871, 103 tons of
_Cassia Fistula_ and Tamarinds.—_Consular Reports_, 1873, part i.

Those of _C. grandis_ L. f. (_C. brasiliana_ Lamarck), a tree of
Central America and Brazil, are of much larger size, showing when
broken transversely an elliptic outline, whose longer diameter exceeds
an inch. The valves have very prominent sutures and transverse
branching veins. The pulp is bitter and astringent.

The legumes of _Cassia moschata_ H B K.,[864] a tree 30 to 40 feet
high, growing in New Granada and known there as _Cañafistola de
purgar_, bear a close resemblance to those of _Cassia Fistula_ L.,
except that they are a little smaller and rather less regularly
straight. They contain a sweetish astringent pulp of a bright brown
hue. When crushed and exposed to the heat of a water-bath, they emit
a pleasant odour like sandal-wood. The pulp is coloured dark blackish
green by perchloride of iron.


TAMARINDI PULPA.

_Tamarindus_, _Fructus Tamarindi_; _Tamarinds_; F. _Tamarins_; G.
_Tamarinden_.

=Botanical Origin=—_Tamarindus indica_ L.—The tamarind is a large
handsome tree, growing to a height of 60 to 80 feet, and having
abruptly pinnate leaves of 10 to 20 pairs of small oblong leaflets,
constituting an abundant and umbrageous foliage. Its purplish flower
buds and fragrant, red-veined, white blossoms, ultimately assuming a
yellowish tinge, contribute to its beautiful aspect and cause it to be
generally cultivated in tropical countries.

_T. indica_ appears to be truly indigenous to Tropical Africa between
12° N. and 18° S. lat. It grows not only in the Upper Nile regions
(Sennaar, Kordofan, Abyssinia), but also in some of the remotest
districts visited by Speke, Grant, Kirk, and Stanley, and as far south
as the Zambesi. According to F. von Müller,[865] it occurs in Tropical
Australia.

It is found throughout India, and as it has Sanskrit names it may even
be really wild in at least the southern parts of the peninsula. It
grows in the Indian islands, and Crawfurd[866] has adduced reasons to
show that it is probably a true native of Java. The mediæval Arabian
authors describe it as growing in Yemen, India, and Nigritia.

The tamarind has been naturalized in Brazil, Ecuador and Mexico.
Hernandez,[867] who resided in the latter country from 1571 to 1575,
speaks of it as “_nuper ... ad eas oras translata_.” It abounds in
the West Indies where it was also introduced together with ginger by
the Spaniards at an early period. The tree found in these islands
bears shorter and fewer-seeded pods than that of India, and hence was
formerly regarded as a distinct species, _Tamarindus occidentalis_
Gärtn.

[864] Hanbury in _Linn. Trans._ xxiv. 161. p. 26; _Pharm. Journ._ v.
(1864) 348; _Science Papers_, p. 318.

[865] Exposition intercoloniale,—_Notes sur la Végétation de
l’Australie_, Melb., 1866. 8.

[866] _Dict. of Indian Islands_, 1856. 425.

[867] _Nova plantarum, animalium et mineralium historia_, Romæ, 1651.
83.

=History=—The tamarind was unknown to the ancient Greeks and Romans;
nor have we any evidence that the Egyptians were acquainted with
it,[868] which is the more surprising considering that the tree appears
indigenous to the Upper Nile countries, and that its fruit is held in
the greatest esteem in those regions.[869]

The earliest mention of tamarind occurs in the ancient Sanskrit
writings where it is spoken of under several names.[870] From the
Hindus, it would seem that the fruit became known to the Arabians,
who called it _Tamare-hindi_, i.e. _Indian Date_. Under this name it
was mentioned by Isaac Judæus,[871] Avicenna,[872] and the Younger
Mesue,[873] and also by Alhervi,[874] a Persian physician of the 10th
century who describes it as black, of the flavour of a Damascene plum,
and containing fibres and stones.

It was doubtless from the Arabians that a knowledge of the tamarind,
as of so many other eastern drugs, passed during the middle ages into
Europe through the famous school of Salernum. _Oxyphœnica_ (Ὀζυϕοίνικα)
and _Dactyli acetosi_ are names under which we meet with it in the
writings of Matthæus Platearius and Saladinus, the latter of whom, as
well as other authors of the period, considered tamarinds as the fruit
of a wild palm growing in India.

The abundance of tamarinds in Malabar, Coromandel, and Java was
reported to Manuel, king of Portugal, in the letter of the apothecary
Pyres[875] on the drugs of India, written in Cochin, January 27th,
1516. A correct description of the tree was given by Garcia de Orta
about fifty years later.

=Preparation=—Tamarinds undergo a certain preparation before being
brought into commerce.

In the West Indies, the tree matures its fruit in June, July and
August, and the pods are gathered when fully ripe, which is known by
the fragility of the outer shell. This latter, which easily breaks
between the finger and thumb, is then removed, and the pods deprived
of shelly fragments are placed in layers in a cask, and boiling syrup
is poured over them till the cask is filled. When cool, the cask is
closed and is then ready for sale. Sometimes layers of sugar are placed
between the fruits previous to the hot syrup being added.[876]

East Indian tamarinds are also sometimes preserved with sugar, but
usually they are exported without such addition, the outer shell being
removed and the fruits being pressed together into a mass.

[868] Sir Gardner Wilkinson (_Ancient Egyptians_, i. 1841, 78) says
that tamarind stones have been found in the tombs of Thebes; but on
consulting Dr. Birch and the collections in the British Museum we have
obtained no confirmation of the fact.

[869] Barth speaks of it as _an invaluable gift of Providence_: _Reisen
und Entdeckungen in Nord-und Centralafrica_, Gotha, 1858. i. 614; iii.
334. 400; iv. 173.—The same says Rohlfs, _Reisen durch Nordafrica_,
Gotha (1872) 23.

[870] _Susrutas Ayurvedas_, ed. Hessler, i. (1844) 141, iii. (1850) 171.

[871] _Opera Omnia_, Lugd. 1515, lib. ii. Practices, c. 41.

[872] _Opera_, Venet. 1564. ii. 339.

[873] _Opera_, Venet. 1561. 52.

[874] _Fundamenta Pharmacologiæ_, ed. Seligmann, Vindob. 1830, 49.

[875] _Journ. de Soc. Pharm. Lusit._ ii. (1838) 36.—See also Appendix.

[876] Lunan, _Hortus Jamaicensis_, ii. (1814) 224; Macfadyen, _Flora of
Jamaica_, 1837. 335.

In the Upper Nile regions (Darfur, Kordofan, Sennaar) and in Arabia,
the softer part of tamarinds is, for the sake of greater permanence
and convenience of transport, kneaded into flattened round cakes, 4 to
8 inches in diameter and an inch or two thick, which are dried in the
sun. They are of firm consistence and quite black, externally strewn
with hair, sand, seeds and other impurities; they are largely consumed
in Egypt and Central Africa, and sometimes find their way to the south
of Europe as _Egyptian Tamarinds_.

=Description=—The fruit is an oblong, or linear-oblong, strictly
compressed, curved or nearly straight, pendulous legume, of the
thickness of the finger and 3 to 6 inches in length, supported by a
woody stalk. It has a thin but hard and brittle outer shell or epicarp,
which does not split into valves or exhibit any very evident sutures.
Within the epicarp is a firm, juicy pulp, on the surface of which and
starting from the stalk are strong woody ramifying nerves; one of these
extends along the dorsal (or concave) edge, two others on either side
of the ventral (or convex) edge, while between these two there are
usually 2, 3, or 4 less regular and more slender nerves,—all running
towards the apex and throwing out branching filaments. The brownish or
reddish pulp has usually an acid taste, though there are also sweetish
varieties.

The seeds, 4 to 12 in number, are each of them enclosed in a tough,
membraneous cell (endocarp), surrounded by the pulp (sarcocarp). They
are flattened and of irregular outline, being roundish, ovate, or
obtusely four-sided, about ⁶/₁₀ of an inch long by ³/₁₀ thick, with the
edge broadly keeled or more often slightly furrowed. The testa is of
a rich brown, marked on the flat sides of the seed by a large scar or
oreole, of rather duller polish than the surrounding portion which is
somewhat radially striated. The seed is exalbuminous, with thick hard
cotyledons, a short straight included radicle, and a plumule in which
the pinnation of the leaves is easily perceptible.

Tamarinds are usually distinguished in trade as _West Indian_ and _East
Indian_, the former being preserved with sugar, the latter without.

1. _West Indian Tamarinds_, _Brown or Red Tamarinds._—A bright
reddish-brown, moist, saccharine mass consisting of the pulpy internal
part of the fruit, usually unbroken, mixed with more or less of syrup.
It has a very agreeable and refreshing taste, the natural acidity of
the pulp being tempered by the sugar. It is this form of tamarinds that
is usually found in the shops.

2. _East Indian Tamarinds_, _Black Tamarinds._—These differ from the
last described in that they are preserved without the use of sugar.
They are found in the market in the form of a firm, clammy, black mass,
consisting of the pulp mixed with the seeds, stringy fibres, and some
remains of the outer shell. The pulp has a strong acid taste.

Notwithstanding the rather uninviting appearance of East Indian
tamarinds, they afford a good pulp, which may be satisfactorily used
in making the _Confectio Sennæ_ of pharmacy. In fact, on the continent
this sort of tamarind alone is employed for medicinal purposes.

=Microscopic Structure=—The soft part of tamarind consists of a tissue
of thin-walled cells of considerable size, which is traversed by long
fibro-vascular bundles. In the former a few very small starch granules
are met with, and more numerous crystals, which are probably bitartrate
of potassium.

=Chemical Composition=—Water extracts from unsweetened tamarinds,
sugar together with acetic, tartaric and citric acids, the acids
being combined for the most part with potash. The neutralized
solution reduces alkaline cupric tartrate after a while without heat,
and therefore probably contains grape sugar. On evaporation, cream
of tartar and sugar crystallize out. The volatile acids of the fatty
series, the presence of which in the pulp has been pointed out by
Gorup-Besanez, have not been met with by other chemists. Tannin is
absent as well as oxalic acid. We have ascertained that in East Indian
tamarinds, citric acid is present in but small quantity. No peculiar
principle to which the laxative action of tamarinds can be attributed
is known.

The fruit-pulp diffused in water forms a thick, tremulous, somewhat
glutinous and turbid liquid. It was examined as early as the year 1790
by Vauquelin under the name of “_vegetable jelly_,”—the first described
among the pectic class of bodies.

The hard _seeds_ have a testa which abounds in tannin, and after long
boiling is easily separated, leaving the cotyledons soft. These latter
have a bland mucilaginous taste, and are consumed in India as food
during times of scarcity.

=Commerce=—Tamarinds are shipped in comparatively small quantities from
several of the West Indian islands, and also from Guayaquil.

The export from the Bombay Presidency in the year 1871-72 was 6286
cwt., which quantity was shipped chiefly to the Persian Gulf, Sind, and
ports of the Red Sea.[877] 128,144 centners were re-exported in 1877
from Trieste.

=Uses=—In medicine, tamarinds are considered to be a mild laxative;
they are sometimes used to make a refrigerant drink in fever. In hot
countries, especially the interior of Africa, they are regarded as of
the highest value for the preparation of refreshing beverages. The
_Black Tamarinds_ are said to be used in the manufacture of tobacco.

[877] _Statement of the Trade and Navigation of the Presidency of
Bombay_, 1871-72, pt. ii. 65.


BALSAMUM COPAIBA.

_Copaiba_; _Balsam of Copaiba or Copaiva_, _Balsam Capivi_; F. _Baume
ou Oléo-résine de Copahu_; G. _Copaivabalsam_.

=Botanical Origin=—The drug under notice is produced by trees belonging
to the genus _Copaifera_, natives of the warmer countries of South
America. Some are found in moist forests, others exclusively in dry
and elevated situations. They vary in height and size, some being
umbrageous forest trees, while others have only the dimension of
shrubs; it is from the former alone that the oleo-resin is obtained.

The following are reputed to furnish the drug, but to what extent each
contributes is not fully known.

1. _Copaifera officinalis_ L. (_C. Jacquini_ Desf.), a large tree
of the hot coast region of New Granada as far north as Panama, of
Venezuela and the island of Trinidad.

2. _C. guianensis_ Desf., a tree of 30 to 40 feet high, very closely
related to the preceding, native of Surinam, Cayenne, also of the Rio
Negro between Manaos and Barcellos (Spruce). According to Bentham it
seems to be the same species as the _C. bijuga_ of Hayne.[878]

3. _C. coriacea_ Mart. (_C. cordifolia_ Hayne), a large tree found in
the _caatingas_ or dry woods of the Brazilian provinces of Bahia and
Piauhy.

4. _C. Langsdorffii_ Desf.[879] (_C. nitida_ Hayne, _C. Sellowii_
Hayne,? _C. Jussieui_ Hayne), a polymorphous species, varying in the
form and size of leaflets, and also in dimensions, being either a
shrub, a small bushy tree, or a large tree of 60 feet high. Bentham
admits, besides the type, three varieties:—β. _glabra_ (_C. glabra_
Vogel), γ. _grandifolia_, δ. _laxa_ (_C. laxa_ Hayne). The tree grows
on dry _campos_, _caatingas_ and other places in the provinces of
S. Paulo, Minas Geraes, Goyaz, Mato Grosso, Bahia and Ceará; it is
therefore distributed over a vast area. According to Gardner,[880] the
Brazilian traveller, it yields an abundance of balsam.

In addition to these species, must be mentioned a tree described by
Hayne and commonly cited under the name of _Copaifera multijuga_, as a
special source of the drug shipped from Pará.[881] As its name implies,
it is remarkable for the number of leaflets (6 to 10 pairs) on each
leaf. But it is only known from some leaves in the herbarium of Martius
which Bentham, who has examined them, informs us are unlike those
of any _Copaifera_ known to him, though certainly the leaflets are
dotted with oil-vessels as in some species. In the absence of flowers
and fruits, there is no sufficient evidence to prove that it belongs
even to the genus _Copaifera_. It is not mentioned by Martius in his
_Systema Materiæ Medicæ Brasiliensis_ (1843) as a source of the drug.

=History=—Among the early notices of Brazil is a treatise by a
Portuguese friar who had resided in that country from 1570 to 1600.
The manuscript found its way to England, was translated, and was
published by Purchas[882] in 1625. Its author notices many of the
natural productions of the country, and among others _Cupayba_ which
he describes as a large tree from whose trunk, when wounded by a deep
incision, there flows in abundance a clear oil much esteemed as a
medicine.

Balsam. _Copæ. yvæ_ is already enumerated in the 6th edition of the
Pharmacopœa of Amsterdam, A.D. 1636.[883]

Father Cristoval d’Acuña,[884] who ascended the Amazon from Pará,
arriving at Quito in 1638, mentions that the country affords very
large Cassia fistula, excellent sarsaparilla, and the oils of Andirova
(_Carapa guianensis_ Aublet, _Meliaceæ_), and _Copaiba_, as good as
balsam for curing wounds.

Piso and Marcgraf,[885] who in 1636 accompanied the Count of Nassau
to the Dutch establishments in Brazil, each give an account of the
_Copaiba_ and the method of obtaining its oleo-resin. The former states
that the tree grows in Pernambuco and the island of Maranhon, whence
the balsam is conveyed in abundance to Europe.

[878] Hayne (1827) enumerated and figured 15 species, some of
them founded on very imperfect materials. Bentham in the _Flora
Brasiliensis_ of Martius and Endlicher (fasc. 50, _Leguminosæ_, ii.
1870. pp. 239-244) admits only 11, one of which is doubtful as to the
genus.

[879] Fig. in Bentley and Trimen, _Med. Plants_, part 32 (1878);
Langsdorffii, not Lansdorffi, is to be written; see _Pharm. Journ._ ix.
(1879) 773.

[880] MS. attached to specimens in the Kew Herbarium.

[881] “Alle Arten geben mehr oder weniger Balsam, und den meisten giebt
die in der Provinz Para vorkommende _Copaifera multijuga_.”—Hayne,
_Linnæa_, i. (1826) 429.

[882] _Pilgrimes and Pilgrimage_, Lond. iv. (1625) 1308.

[883] _Pharm. Journ._ vi. (1876) 1021.

[884] _Nuevo Descubrimiento del gran Rio de las Amazonas_, Madrid,
1641, No. 30.

[885] _Hist. Nat. Brasiliæ_:, 1648, Piso, 56, Marcgraf, 130.

The drug was formerly brought into European commerce by the Portuguese,
and used to be packed in earthen pots pointed at the lower end;
it often arrived in a very impure condition.[886] In the London
Pharmacopœia of 1677, it was called _Balsamum Capivi_, which is still
its most popular name.

=Secretion=—Karsten states that he observed resiniferous ducts,
frequently more than an inch in diameter, running through the whole
stem. He is of the opinion that the cell-walls of the neighbouring
parenchyme are liquefied and transformed into the oleo-resin.[887] We
are not able to offer any argument in favour of this opinion.

In the vessels already alluded to, the balsam sometimes collects in
so large a quantity, that the trunk is unable to sustain the inward
pressure, and _bursts_. This curious phenomenon is thus referred to
in a letter addressed to one of us by Mr. Spruce:—“I have three or
four times heard what the Indians assured me was the bursting of an
old capivi-tree, distended with oil. It is one of the strange sounds
that sometimes disturb the vast solitudes of a South American forest.
It resembles the boom of a distant cannon, and is quite distinct
from the crash of an old tree falling from decay which one hears not
unfrequently.”

A similar phenomenon is known in Borneo. The trunks of aged trees of
_Dryobalanops aromatica_ contain large quantities of oleo-resin or
Camphor Oil,[888] which appears to be sometimes secreted under such
pressure that the vast trunk gives way. “There is another sound,” says
Spenser St. John,[889] “only heard in the oldest forests, and that is
as if a mighty tree were rent in twain. I often asked the cause, and
was assured it was the camphor tree splitting asunder on account of the
accumulation of camphor in some particular portion.”

=Extraction=—Balsam Capivi is collected by the Indians on the banks
of the Orinoco and its upper affluents, and carried to Ciudad Bolivar
(Angostura); some of this balsam reaches Europe by way of Trinidad. But
it is obtained much more largely on the tributaries of the Caisquiari
and Rio Negro (the Siapa, Içanna, Uaupés, etc.) and is sent down to
Pará. Most of the northern tributaries of the Amazon, as the Trombetas
and Nhamundá, likewise furnish a supply. According to Spruce, in
the Amazon valley it is the tall virgin forest, _Caaguaçú_ of the
Brazilians, _Monte Alto_ of the Venezuelans, that yields most of the
oils and gum-resins, and not the low, dry _caatingas_, or the riparial
forests. The same observant traveller tells us that in Southern
Venezuela, capivi is known only as _el Aceite de palo_ (_wood-oil_),
the name _Balsamo_ being that of the so-called _Sassafras Oil_,
obtained from a species of _Nectandra_.

[886] Valmont de Bomare, _Dict. d’Hist. Nat._ i. (1775) 387.

[887] _Botanische Zeitung_, xv. (1857) 316.

[888] Motley in Hooker’s _Journ. of Botany_, iv. (1852) 201.

[889] _Life in the Forests of the Far East_, ii. (1862) 152.

Balsam Copaiba is also largely exported from Maracaibo where, according
to Engel,[890] it is produced by _C. officinalis_, the Canime of the
natives.

The finest sort, called by the collectors white copaiba, is met with in
the province of Pará, where Cross[891] saw a tree of a circumference
of more than 7 feet at 3 feet from the ground. Its trunk was clear of
branches to a height of at least 90 feet. The collector commenced the
work by hewing out with his axe a hole or chamber in the trunk about
a foot square, at a height of two feet from the ground. The base or
floor of the chamber should be carefully and neatly cut with a gentle
upward slope, and it should also decline to one side, so that the
balsam on issuing may run in a body until it reaches the outer edge.
Below the chamber a pointed piece of bark is cut and raised, which,
enveloped with a leaf, serves as a spout for conveying the balsam from
the tree to the tin.[892] The balsam, continues Cross, came flowing in
a moderate sized cool current, full of air bubbles. At times the flow
stopped for several minutes, when a singular gurgling noise was heard,
after which followed a rush of balsam. When coming most abundantly a
pint jug would have been filled in the space of one minute. The whole
of the wood cut through by the axeman was bedewed with drops of balsam;
the bark is apparently devoid of it. Trees of the largest size in
good condition will sometimes yield four “potos,” equal to 84 English
imperial pints.

=Description=—Copaiba is more or less viscid fluid, varying in tint
from a pale yellow to a light golden brown, of a peculiar aromatic,
not unpleasant odour, and a persistent, acrid, bitterish taste. Pará
copaiba newly imported is sometimes nearly colourless and almost as
fluid as water.[893] The balsam is usually quite transparent, but
there are varieties which remain always opalescent. Its sp. gr. varies
from 0·940 to 0·993, according as the drug contains a greater or less
proportion of volatile oil. Copaiba becomes more fluid by heat; if
heated in a test tube to 200° C. for some time, it does not lose its
fluidity on cooling. It is sometimes slightly fluorescent, it dissolves
in several times its weight of alcohol 0·830 sp. gr., and generally in
all proportions in absolute alcohol,[894] acetone, or bisulphide of
carbon, and is perfectly soluble in an equal volume of benzol. Glacial
acetic acid readily dissolves the resin but not the essential oil.

Copaiba that is rich in resin of an acid character, unites with the
oxides of baryum, calcium, or magnesium, to form a gradually hardening
mass, provided a small proportion of water is present. Thus 8 to 16
parts of balsam will combine as a stiff compound when gently warmed
with 1 part of moistened magnesia; and still more easily with lime or
baryta.

[890] _Zeitschrift der Gesellschaft für Erdkunde zu Berlin_, v. (1870)
435.

[891] Report to the Under Secretary of State for India, on the
investigation and collecting of plants and seeds of the india-rubber
trees of Pará and Ceara, and Balsam of Copaiba. March 1877,—8.

[892] See figure in the above Report.

[893] We saw such as this which had been imported into London in 1873;
though regarded by the dealers with suspicion, we are not of opinion
that it was sophisticated.

[894] Such is the case with some very authentic specimens collected
for one of us in Central America by De Warszewicz, but other samples
which we had up reason to suppose adulterated, left a certain amount of
white residue when treated with _twice their weight_ of alcohol sp. gr.
0·796.

Buignet has first shown (1861) that copaiba varies in its optical
power. A sample from Trinidad examined by one of us was strongly
dextrogyre, and also several samples imported in 1877 from Maturin
(near Aragua, Venezuela), and Maracaibo into Hamburg, whereas we found
Pará balsam to be levogyre.[895]

The Pará and Maranham balsams are regarded in wholesale trade as
distinct sorts, and experienced druggists are able to distinguish
them apart by odour and appearance, and especially by the greater
consistence of the Maranham drug. Maracaibo balsam is reckoned as
another variety, but is now rarely seen in the English market. West
Indian copaiba is usually said to be of inferior quality, but except
that it is generally opalescent, we know not on what precise grounds.

=Chemical Composition=—The balsam is a solution of resin in volatile
oil; the latter constitutes about 40 to 60 per cent. of the
balsam,[896] according to the age of the latter and its botanical
origin. The oil has the composition C₁₅H₂₄; its boiling point is 245°
C. or even higher. It smells and tastes like the balsam, and dissolves
in from 8 to 30 parts of alcohol 0·830 sp. gr. The oil exhibits several
modifications differing in optical as well as in other physical
properties, but numerous samples of the drug, either _dextrogyre_ or
levogyre, invariably afforded us essential oils deviating to the left;
their sp. gr. varies from about 0·88 to 0·91.

After the oil of copaiba has been removed by distillation, there
remains a brittle amorphous resin of an acid character soluble both in
benzol and amylic alcohol, and yielding only amorphous salts. Sometimes
copaiba contains a small amount of crystallizable resin-acid, as
first pointed out in 1829 by Schweitzer. By exposing a mixture of 9
parts of copaiba and two parts of aqueous ammonia (sp. gr. 0·95) to a
temperature of-10° C., Schweitzer obtained crystals of the acid resin
termed _Copaivic Acid_. They were analysed in 1834 by H. Rose, and
exactly measured and figured by G. Rose. Hess (1839) showed that Rose’s
and his own analyses assign to copaivic acid the formula C₂₀H₃₂O₂. It
agrees with Maly’s abietic acid from colophony in composition, but not
in any other way. Copaivic acid is readily soluble in alcohol, and
especially in warmed copaiba itself; much less in ether. We have before
us crystals, no doubt of copaivic acid, which have been spontaneously
deposited in an authentic specimen of the oleo-resin of _Copaifera
officinalis_ from Trinidad, which we have kept for many years. The
crystals may be easily dissolved by warming the balsam; on cooling the
liquid, they again make their appearance after the lapse of some weeks.
After recrystallization from alcohol they fuse at 116-117 C°., forming
an amorphous transparent mass which quickly crystallizes if touched
with alcohol.

An analogous substance, _Oxycopaivic Acid_, C₂₀H₂₈O₃, was examined in
1841 by H. von Fehling, who met with it as a deposit in Pará Copaiba.
And lastly Strauss (1865) extracted _Metacopaivic Acid_, C₂₂H₃₄O₄, from
the balsam imported from Maracaibo. He boiled the latter with soda-lye,
which separated the oil; the heavier adjacent liquid was then mixed
with chloride of ammonium, which threw down the salts of the amorphous
resin-acid, leaving in solution those of the metacopaivic acid. The
latter acid was separated by hydrochloric acid and recrystallization
from alcohol. We succeeded in obtaining metacopaivic acid by washing
the balsam with a dilute solution of carbonate of ammonium, and
precipitating by hydrochloric acid. The precipitate dissolved in dilute
alcohol yields the acid in small crystals, but to the amount of only
about one per cent.

[895] Flückiger in Wiggers and Husemann’s _Jahresbericht_ for 1867.
162, and for 1868. 140.

[896] Or 18 to 65 per cent., sp. gr. 0·915 to 0·995, according to
Siebold (1877).

These resin-acids have a bitterish taste and an acid reaction; their
salts of lead and silver are crystalline but insoluble; metacopaivate
of sodium may be crystallized from its watery solution.

=Commerce=—The balsam is imported in barrels direct from Pará and
Maranham, sometimes from Rio de Janeiro, and less often from Demerara,
Angostura, Trinidad, Maracaibo, Savanilla, and Cartagena. It often
reaches England by way of Havre and New York. In 1875 there were
exported 10,150 kilogrammes from Savanilla, 99,800 lb. from Ciudad
Bolivar (Angostura), and 65,243 kilos. from Pará.

=Uses=—Copaiba is employed in medicine on account of its stimulant
action on the mucous membranes, more especially those of the
urino-genital organs.

=Adulteration=—Copaiba is not unfrequently fraudulently tampered
with before it reaches the pharmaceutist; and owing to its naturally
variable composition, arising in part from its diverse botanical
origin, its purity is not always easily ascertained.

The oleo-resin usually dissolves in a small proportion of absolute
alcohol: should it refuse to do so, the presence of some fatty oil
other than castor oil may be surmised. To detect an admixture of this
latter, one part of the balsam should be heated with four of spirit
of wine (sp. gr. 0·838). On cooling, the mixture separates into two
portions, the upper of which will contain any castor oil present,
dissolved in alcohol and the essential oil. On evaporation of this
upper layer, castor oil may be recognized by its odour; but still more
positively by heating it with caustic soda and lime, when œnanthol will
be formed, the presence of which may be ascertained by its peculiar
smell. By the latter test an admixture of even one per cent. of castor
oil can be proved.

The presence of fatty oil in any considerable quantity is likewise made
evident by the greasiness of the residue, when the balsam is deprived
of its essential oil by prolonged boiling with water.

The admixture of some volatile oil with copaiba can mostly be detected
by the odour, especially when the balsam is dropped on a piece of
warmed metal. Spirit of wine may also be advantageously tried for
the same purpose. It dissolves but very sparingly the volatile oil
of copaiba: the resins of the latter are also not abundantly soluble
in it. Hence, if shaken with the balsam, it would remove at once the
larger portion of any essential oil that might have been added. For the
recognition of Wood Oil if mixed with copaiba, see page 233, note 1.

=Substitutes=—Under this head two drugs deserve mention, namely
_Gurjun Balsam_ or _Wood Oil_, described at p. 88, and _Oleo-resin of
Hardwickia pinnata_ Roxb.—The tree, which is of a large size, belongs
to the order _Leguminosæ_ and is nearly related to _Copaifera_.
According to Beddome,[897] it is very common in the dense moist forests
of the South Travancore Ghats, and has also been found in South Canara.
The natives extract the oleo-resin in exactly the same method as that
followed by the aborigines of Brazil in the case of copaiba,—that is to
say, they make a deep notch reaching to the heart of the trunk, from
which after a time it flows out.

[897] _Flora Sylvatica for Southern India_, Madras, part 24 (1872),
255.

This oleo-resin, which has the smell and taste of copaiba, but a
much darker colour, was first examined by one of us in 1865, having
been sent from the India Museum as a sample of Wood Oil; it was
subsequently forwarded to us in more ample quantity by Dr. Bidie of
Madras. It is a thick, viscid fluid, which, owing to its intense
tint, looks black when seen in bulk by reflected light; yet it is
perfectly transparent. Viewed in a thin layer by transmitted light, it
is light _yellowish-green_, in a thick layer _vinous-red_,—hence is
dichromic. It is not fluorescent, nor is it gelatinized or rendered
turbid by being heated to 130° C., thus differing from Wood Oil.[898]
Broughton[899] obtained by prolonged distillation with water an
essential oil to the extent of 25 per cent. from an old specimen,
and of more than 40 per cent. from one recently collected. The oil
was found to have the same composition as that of copaiba, to boil
at 225° C., and to rotate the plane of polarization to the left. The
resin[900] is probably of two kinds, of which one at least possesses
acid properties. Broughton made many attempts, but without success, to
obtain from the resin crystals of copaivic acid.

The balsam of _Hardwickia_ has been used in India for gonorrhœa, and
with as much success as copaiba.


GUMMI ACACIÆ.

_Gummi Arabicum_; _Gum Arabic_; F. _Gomme Arabique_; G. _Arabisches
Gummi_, _Acacien-Gummi_, _Kordofan-Gummi_.

=Botanical Origin=—Among the plants abounding in mucilage, numerous
Acaciæ of various countries are in the first line. The species
particularly known for affording the largest quantities of the finest
gum arabic is _Acacia Senegal_[901] Willdenow (syn. _Mimosa Senegal_
L., _A. Verek_ Guillemin et Perrottet), a small tree not higher than
20 feet, growing abundantly on sandy soils in Western Africa, chiefly
north of the river Senegal, where it constitutes extensive forests. It
is called by the negroes _Verek_. The same tree is likewise found in
Southern Nubia, Kordofan, and in the region of the Atbara in Eastern
Africa, where it is known as _Hashab_. It has a greyish bark, the inner
layers of which are strongly fibrous, small yellowish flowers densely
arranged in spikes 2 to 3 inches long, and exceeding the bipinnate
leaves, and a broad legume 3 to 4 inches in length containing 5 to 6
seeds.

[898] It may be further distinguished from Wood Oil as well as from
copaiba, if tested in the following simple manner:—Put into a tube
19 drops of bisulphide of carbon and one drop of the oleo-resin, and
shake them together. Then add one drop of a mixture of equal parts of
strong sulphuric and nitric (1·42) acids. After a little agitation the
appearance of the respective mixtures will be as follows:—

_Copaiba_—Colour faint reddish-brown, with deposit of resin on sides of
tube.

_Wood Oil_—Colour intense purplish-red, becoming violet after some
minutes.

_Oleo-resin of Hardwickia_—No perceptible alteration; the mixture pale
greenish yellow.

By this test the presence in copaiba of one-eighth of its volume of
Wood Oil may be easily shown.

[899] Beddome, _op. cit._

[900] See also Hazlett, _Madras Monthly Journ. of Med. Science_, June
1872.

[901] Figures in Guillemin and Perrottet _Floræ Senegamb. tent._ 1830,
p. 246, tab. 56; also Bentley and Trimen, _Med. Plants_, part 17
(1877).

According to Schweinfurth,[902] it is this tree exclusively that yields
the fine white gum of the countries bordering the Upper Nile, and
especially of Kordofan. He states that only brownish or reddish sorts
of gum are produced by the Talch, Talha or Kakul, _Acacia stenocarpa_
Hochstetter, by the Ssoffar, _A. fistula_ Schweinf. (_A. Seyal_ Delile,
var. _Fistula_), as well as by the Ssant or Sont, _A. nilotica_ Desfont
(_A. arabica_ Willd.). These trees grow in north-eastern Africa; the
last named is, moreover, widely distributed all over tropical Africa
as far as Senegambia,[903] Mozambique and Natal, and also extends to
Sindh, Gujarat[904] and Central India. We find even the first sort,
“Karami,” of gum exported from the Somali coast,[905] to be inferior
to good common Arabic gum. Hildebrandt (1875) mentions that gum is
there largely collected from _Acacia abyssinica_ Hochst. and _A.
glaucophylla_ Steudel.

=History=—The history of this drug carries us back to a remote
antiquity. The Egyptian fleets brought gum from the gulf of Aden as
early as the 17th century B.C. Thus in the treasury of king Rhampsinit
(Ramses III.) at Medinet Abu, there are representations of gum-trees,
together with heaps of gum. The symbol used to signify _gum_, is read
_Kami-en-punt_. i.e. _gum_ from the country of Punt. This, in all
probability, includes both the Somali coast as well as that of the
opposite parts of Arabia (see article Olibanum, p. 136). Thus, gum is
of frequent occurrence in Egyptian inscriptions; sometimes mention is
made of gum from Canaan. The word _kami_ is the original of the Greek
κόμμι, whence through the Latin our own word _gum_.[906]

The Egyptians used gum largely in painting; an inscription exists which
states that in one particular instance a solution of _Kami_ (gum) was
used to render adherent the mineral pigment called _chesteb_,[907] the
name applied to lapis lazuli or to a glass coloured blue by cobalt.

Turning to the Greeks, we find that Theophrastus in the 3rd and 4th
century B.C. mentioned Κόμμι as a product of the Egyptian Ἂκανθα, of
which tree there was a forest in the Thebaïs of Upper Egypt. Strabo
also, in describing the district of Arsinöe, the modern Fayûm, says
that gum is got from the forest of the Thebaïc _Akanthe_.

Celsus in the 1st century mentions _Gummi acanthinum_; Dioscorides
and Pliny also describe Egyptian gum, which the latter values at 3
_denarii_ [2_s._] per lb.

In those times gum no doubt used to be shipped from north-eastern
Africa to Arabia; there is no evidence showing that Arabia itself had
ever furnished the chief bulk of the drug. The designation gum _arabic_
occurs in Diodorus Siculus (2, 49) in the first century of our era,
also in the list of goods of Alexandria mentioned in our article on
Galbanum.

[902] _Aufzählung und Beschreibung der Acacien-Artendes
Nilgebiets.—Linnæa_, i. (1867) 308-376, with 21 plates. Schweinfurth’s
observations are strongly confirmed by an account of the commerce of
Khartum in the _Zeitschrift für Erdkunde_, ii. (1867, Berlin) 474.

[903] The _A. Adansonii_ Guill. et Perr. is the same tree.

[904] The “_Kikar_” of the Punjaub, or “_Babul_” or “_Babur_” of
Central India.

[905] As presented to me by Capt. Hunter of Aden, July 1877.—F. A. F..

[906] We have to thank Professor Dümichen for most of the information
relating to Egypt, which may be partly found in his own works, and
partly in those of Brugsch, Ebers, and Lepsius.

[907] Lepsius, _Abhandl. der Akademie der Wissensch. zu Berlin_ for
1871, p. 77. 126. Metalle in den Aegyptischen Inschriften.

Gum was employed by the Arabian physicians and by those of the school
of Salerno, yet its utility in medicine and the arts was but little
appreciated in Europe until a much later period. For the latter purpose
at least the gummy exudations of indigenous trees were occasionally
resorted to, as distinctly pointed out about the beginning of the 12th
century, by Theophilus or Rogker:[908] “gummi quot exit de arbore
ceraso vel pruno.“

During the middle ages, the small supplies that reached Europe were
procured through the Italian traders from Egypt and Turkey. Thus
Pegolotti,[909] who wrote a work on commerce about A.D. 1340, speaks of
gum arabic as one of the drugs sold at Constantinople by the _pound_
not by the _quintal_. Again, in a list of drugs liable to duty at Pisa
in 1305,[910] and in a similar list relating to Paris in 1349,[911] we
find mention of gum arabic. It is likewise named by Pasi,[912] in 1521,
as an export from Venice to London.

Gum also reached Europe from Western Africa, with which region the
Portuguese had a direct trade as early as 1449.

=Production=—Respecting the origin of gum in the tribe _Acaciæ_,
no observations have been made similar to those of H. von Mohl on
tragacanth.[913]

It appears that gum generally exudes from the trees spontaneously,
in sufficient abundance to render wounding the bark superfluous. The
Somali tribes of East Africa, however, are in the habit of promoting
the outflow by making long incisions in the stem and branches of the
tree.[914] In Kordofan the lumps of gum are broken off with an axe, and
collected in baskets.

The most valued product, called _Hashabi_ gum, from the province of
Dejara in Kordofan, is sent northward from Bara and El Obeid to Dabbeh
on the Nile, and thence down the river to Egypt; or it reaches the
White Nile at Mandjara.

A less valuable gum, known as _Hashabi el Jesire_, comes from Sennaar
on the Blue Nile; and a still worse from the barren table-land of
Takka, lying between the eastern tributaries of the Blue Nile and the
Atbara and Mareb; and from the highlands of the Bisharrin Arabs between
Khartum and the Red Sea. This gum is transported by way of Khartum or
El Mekheir (Berber), or by Suakin on the Red Sea. Hence, the worst kind
of gum is known in Egypt as _Samagh Savakumi_ (_Suakin Gum_).

According to Munzinger,[915] a better sort of gum is produced along
the Samhara coast towards Berbera, and is shipped at Massowa. Some of
it reaches Egypt by way of Jidda, which town being in the district of
Arabia called the Hejaz, the gum thence brought receives the name of
_Samagh Hejazi_; it is also called _Jiddah_ or _Gedda Gum_. The gums
of Zeila, Berbera and the Somali country about Gardafui, are shipped
to Aden, or direct to Bombay. A little gum is collected in Southern
Arabia, but the quantity is said to be insignificant.[916]

[908] _Schedula diversarum artium_, Ilg’s edition in Eitelberger’s
_Quellenschriften für Kunstgeschichte_, vii. (1874) 60.

[909] _Della Decima e di varie altre gravezze imposte dal commune di
Firenze_, iii. (1766) 18.

[910] Bonaini, _Statuti inediti della città di Pisa_, Firenze, iii.
(1857) 106. 114.

[911] _Ordonnances des Rois de France_, ii. (1729) 310.

[912] _Tariffa de pesi e misure_, Venet. 1521. 204. First edition, 1503.

[913] See, however, Möller, Academy of Vienna, _Sitzungsberichte_, June
1875.

[914] Vaughan (Drugs of Aden), _Pharm. Journ._ xii. (1853) 226.

[915] Private information to F. A. F..

[916] Vaughan, _l.c._

In the French colony of Senegal, gum, which is one of its principal
productions, is collected chiefly in the country lying north of the
river, by the Moors who exchange it for European commodities. The
gathering commences after the rainy season in November when the wind
begins to set from the desert, and continues till the month of July.
The gum is shipped for the most part to Bordeaux. The quantity annually
imported into France since 1828 from Senegal is varying from between 1½
to 5 millions of kilogrammes.

=Description=—Gum arabic does not exhibit any very characteristic
forms like those observable in gum tragacanth. The finest white gum
of Kordofan, which is that most suitable for medicinal use, occurs in
lumps of various sizes from that of a walnut downwards. They are mostly
of ovoid or spherical form, rarely vermicular, with the surface in the
unbroken masses, rounded,—in the fragments, angular. They are traversed
by numerous fissures, and break easily and with a vitreous fracture.
The interior is often less fissured than the outer portion. At 100° C.
the cracks increase, and the gum becomes extremely friable. In moist
air, it slowly absorbs about 6 per cent. of water.

The finest gum arabic is perfectly clear and colourless; inferior
kinds have a brownish, reddish or yellowish tint of greater or
less intensity, and are more or less contaminated with accidental
impurities such as bark. The finest white gum turns black and assumes
an empyreumatic taste, when it is kept for months at a temperature of
about 98° C., either in an open vessel, or enclosed in a glass tube,
after having been previously dried over sulphuric acid or not.

An aqueous solution of gum deviates the plane of polarization 5° to the
left in a column 50 mm. long; but after being long kept, it becomes
strongly acid, the gum having been partly converted into sugar, and its
optical properties are altered. An alkaline solution of cupric tartrate
is not reduced by solution of gum even at a boiling heat, unless it
contains a somewhat considerable proportion of sugar, extractable by
alcohol, or a fraudulent admixture of dextrin.

We found the sp. gr. of the purest pieces of colourless gum dried in
the air at 15° C., to be 1·487; but it increases to 1·525, if the gum
is dried at 100°.

The foregoing remarks apply chiefly to the fine white gum of Kordofan,
the _Picked Turkey Gum_ or _White Sennaar Gum_ of druggists. The other
sorts which are met with in the London market are the following:—

1. _Senegal Gum_—As stated above, this gum is an important item of the
French trade with Africa, but is not much used in England. Its colour
is usually yellowish or somewhat reddish, and the lumps, which are of
large size, are often elongated or vermicular. Moreover Senegal gum
never exhibits the numerous fissures seen in Kordofan gum, so that the
masses are much firmer and less easily broken. In every other respect,
whether chemical or optical, we find[917] Senegal gum and Kordofan
gum to be identical; and the two, notwithstanding their different
appearance, are produced by one and the same species of _Acacia_,
namely _Acacia Senegal_.

2. _Suakin Gum, Talca_ or _Talha Gum_, yielded by _Acacia
stenocarpa_, and by _A. Seyal_ var. _Fistula_, is remarkable for its
brittleness, which occasions much of it to arrive in the market in a
semi-pulverulent state. It is a mixture of nearly colourless and of
brownish gum, with here and there pieces of a deep reddish-brown. Large
tears have a dull opaque look, by reason of the innumerable minute
fissures which penetrate the rather bubbly mass. It is imported from
Alexandria.

3. _Morocco, Mogador_ or _Brown Barbary Gum_—consists of tears of
moderate size, often vermiform, and of a rather uniform, light, dusky
brown tint. The tears which are internally glassy become cracked on the
surface and brittle if kept in a warm room; they are perfectly soluble
in water. The above mentioned _Acacia nilotica_ is supposed to be the
source of the gum exported from Morocco, and also from Fezzan.

Gums of various kinds, including the resin Sandrac, were exported from
Morocco in the year 1872 to the extent of 5110 cwt., a quantity much
below the average.[918]

4. _Cape Gum_—This gum, which is uniformly of an amber brown, is
produced in plenty in the Cape Colony, as a spontaneous exudation of
_Acacia horrida_ Willd. (_A. Karroo_ Hayne, _A. capensis_ Burch.), a
large tree, the _Doornboom_, _Wittedoorn_ or _Karródoorn_ of the Cape
colonists, the commonest tree of the lonely deserts of South Africa.
The _Blue Book_ of the Cape Colony, published in 1873, states the
export of gum in 1872 as 101,241 lb.

5. _East India Gum_—The best qualities consist of tears of various
sizes, sometimes as large as an egg, internally transparent and
vitreous, of a pale amber or pinkish hue, completely soluble in water.
This gum is largely shipped from Bombay, but is almost wholly the
produce of Africa; the imports into Bombay from the Red Sea ports, Aden
and the African Coast in the year 1872-73, were 14,352 cwt. During the
same year the shipments from Bombay to the United Kingdom amounted to
4,561 cwt.[919]

6. _Australian Gum, Wattle Gum_—This occurs in large hard globular
tears and lumps, occasionally of a pale yellow, yet more often of an
amber or of a reddish-brown hue. It is transparent and entirely soluble
in water; the mucilage is strongly adhesive, and said to be less
liable to crack when dry than that of some other gums. The solution,
especially that of the darker and inferior kinds, contains a little
tannin, evidently derived from the very astringent bark which is often
attached to the gum.

_A. pycnantha_ Benth.; _A. decurrens_ Willd. (_A. mollissima_ Willd.,
_A. dealbata_ Link), _Black_ or _Green Wattle-tree_ of the colonists,
and _A. homalophylla_ A. Cunn., are the trees which furnish the gum
arabic of Australia.[920]

[917] Flückiger, in the _Jahresbericht_ of Wiggers and Husemann, 1869.
149.

[918] _Consular Reports_, August, 1873. 917.

[919] _Statement of the Trade and Navigation of the Presidency of
Bombay for_ 1872-73, pt. ii. 34. 77.

[920] P. von Müller, _Select Plants for industrial culture in
Victoria_. 1876; 2. 4.

=Chemical Characters and Composition=—At ordinary temperatures gum
dissolves very slowly and without affecting the thermometer in an
equal weight of water, forming a thick, glutinous, slightly opalescent
liquid, having a mawkish taste and decidedly acid reaction. At higher
temperatures the dissolution of gum is but slightly accelerated, and
water does not take up a much larger quantity even at 100°. The finest
gum dried at 100° C. forms with two parts of water a mucilage of sp.
gr. 1·149 at 15° C.

This solution mixes with glycerine, and the mixture may be evaporated
to the consistence of a jelly without any separation taking place.
Solid gum in lumps, on the contrary, is but little affected by
concentrated glycerine. In other liquids, gum is insoluble or only
slightly soluble, unless there is a considerable quantity of water
present. Thus 100 parts of spirit of wine containing 22 volumes per
cent. of alcohol, dissolve 57 parts of gum; spirit containing 40 per
cent. of alcohol takes up 10 parts, and spirit of 50 per cent. only 4
parts. Aqueous alcohol of 60 per cent. no longer dissolves gum, but
extracts from it a small quantity (⅓ to ½ per cent. according to the
variety) of resin colouring matter, glucose, calcium chloride, and
other salts.

Neutral acetate of lead does not precipitate gum arabic mucilage; but
the basic acetate forms, even in a very dilute solution, a precipitate
of definite constitution.

Soluble silicates, borates, and ferric salts render gum solution
turbid, or thicken it to a jelly. It is not a compound of gum with any
of these substances which is formed, but in the cases of the first,
basic silicates separate. No alteration is produced by silver salts,
mercuric chloride or iodine. Ammonium oxalate throws down the lime
contained in a solution of gum. Gum dissolves in an ammoniacal solution
of cupric oxide. Acted upon by nitric acid, mucic acid is produced.

Small, air-dried lumps of gum lose by desiccation over concentrated
sulphuric acid (or by heating them in the water-bath) 12 to 16 per
cent. of water. If gum independently of its amount of lime, be
presented by the formula C₁₂H₂₂O₁₁ + 3H₂O, the loss of 3 molecules
of water will correspond to a decrease in weight of 13·6 per cent.;
in carefully selected colourless pieces, we have found it to amount
to 13·14 per cent. At a temperature of about 150° C., gum parts with
another molecule of water, and partly loses its solubility and assumes
a brownish hue and empyreumatic taste. Gum already by keeping it for
a week at a temperature not exceeding 95° C. gradually acquires a
decidedly empyreumatic taste. We have also observed, on the other hand,
a fine white gum affording an imperfect solution which was _glairy_,
like the mucilage of marshmallow, but in no other respect could we find
that it differed from ordinary gum. On exposing it for some days to a
temperature of 95° C., it afforded a solution of the usual character.

When gum arabic is dissolved in cold water and the solution is slightly
acidulated with hydrochloric acid, alcohol produces it in a precipitate
of _Arabin_ or _Arabic Acid_. It may be also prepared by placing a
solution of gum (1 gum + 5 water), acidulated with hydrochloric acid,
on a dialyser, when the calcium salt will diffuse out, leaving behind a
solution of arabin.

Solution of arabin differs from one of gum in not being precipitated by
alcohol. Having been dried, it loses its solubility, merely swelling
in water, but not dissolving even at a boiling heat. If an alkali is
added, it forms a solution like ordinary gum. Neubauer who observed
these facts (1854-57) showed that gum arabic is essentially an acid
calcium salt of arabic acid.

_Arabic Acid_ dried at 100° C. has the composition C₁₂H₂₂O₁₁, and gives
up H₂O when it unites with bases. It has however a great tendency to
form salts containing a large excess of acid. An acid calcium arabate
of the composition (C₁₂H₂₁O₁₁)₂Ca + 3 (C₁₂H₂₂O₁₁ + 5 OH) would afford
by incineration 4·95 per cent. of calcium carbonate. Nearly this
amount of ash is in fact sometimes yielded by gum. The most carefully
selected colourless pieces of it yield from 2·7 to 4 per cent. of ash,
consisting mainly of calcium carbonate, but containing also carbonates
of potassium and magnesium. Phosphoric acid appears never to occur in
gums.

Natural gum may therefore be regarded as a salt of arabic acid having a
large excess of acid, or perhaps as a mixture of such salts of calcium,
potassium and magnesium. It is to the presence of these bases, which
are doubtless derived from the cell-wall from which the gum exuded,
that gum owes its solubility.

It still remains unexplained why certain gums, not unprovided with
mineral constituents, merely swell up in water without dissolving, thus
materially differing from gum arabic. There is also a marked difference
between gum arabic and many other varieties of gum or mucilage, which
immediately form a plumbic compound if treated with neutral acetate
of lead. The type of the swelling, but not really soluble gums, is
Tragacanth, but there are a great many other substances of the same
class, some of them perfectly resembling gum arabic in external
appearance. The name of _Bassora gum_ has also been applied to the
latter kinds.

=Commerce=—The imports of Gum Arabic into the United Kingdom have been
as follows:—

          1871                1872
       76,136 cwt.          42,837 cwt.
    value £250,088.      value £123,080.

The country whence by far the largest supplies are shipped, is Egypt.

=Uses=—Gum is employed in medicine rather as an adjuvant than as
possessing any remedial powers of its own.

=Substitutes=—A great number of trees are capable of affording gums
more or less similar to gum arabic. There is to be mentioned for
instance _Prosopis glandulosa_ Torrey, a tree growing from 30 to 40
feet in height, occurring very abundantly in Texas, and extending as
far west as the Colorado and the gulf of California. It is universally
known by its Mexican name _Mesquite_. It belongs to the same suborder
of the Mimosæ like the Acaciæ tribe of the Adenanthereæ. _Mesquite gum_
agrees not with the fine description, but with the inferior sorts of
gum arabic, and is sometimes used in America,[921] since 1854, in the
manufacture of confectionery and the arts.

_Feronia Gum_, or _Wood Apple Gum_. This is the produce of _Feronia
Elephantum_ Correa, a spiny tree, 50 to 60 feet high, of the order of
_Aurantiaceæ_, common throughout India from the hot valleys of the
Himalaya to Ceylon, and also found in Java. There exudes from its bark
abundance of gum, which appears not to be collected for exportation
_per se_, but rather to be mixed indiscriminately with other gum, as
that of _Acacia_.

[921] See _Proceedings of Am. Pharm. Assoc._ 1875. 647; _Am. Journ. of
Pharm._ 1878. 480.

Feronia gum sometimes forms small roundish transparent, almost
colourless tears, more frequently stalactitic or knobby masses, of a
brownish or reddish colour, more or less deep. In an authentic sample,
for which we are indebted to Dr. Thwaites of Ceylon, horn-shaped pieces
about ½ an inch thick and two inches long also occur.

Dissolved in two parts of water, it affords an almost tasteless
mucilage, of much greater viscosity than that of gum arabic made in
the same proportions. The solution reddens litmus, and is precipitated
like gum arabic by alcohol, oxalate of ammonium, alkaline silicates,
perchloride of iron, but not by borax. Moreover, the solution of
Feronia gum is precipitated by neutral acetate of lead or caustic
baryta, but not by potash. If the solution is completely precipitated
by neutral acetate of lead, the residual liquid will be found to
contain a small quantity of a different gum, identical apparently with
gum arabic, inasmuch as it is not thrown down by acetate of lead.
If the lime is precipitated from the Feronia mucilage by oxalate of
potassium, the gum partially loses its solubility and forms a turbid
liquid.

From the preceding experiments, it follows that a larger portion of
Feronia gum is by no means identical with gum arabic. The former, when
examined in a column of 50 mm. length, deviates the rays of polarized
light 0°·4 to the right,—not to the _left_ as gum arabic. This was, we
believe, the first instance of a dextrogyre gum;[922] Scheibler has
afterwards shown (1873) that there are also dextrogyre varieties among
the African gum from Sennar. Gum arabic may be combined with oxide of
lead; the compound (arabate of lead) contains 30·6 per cent. of oxide
of lead, whereas the plumbic compound of Feronia gum, dried at 110° C.,
yielded us only 14·76 per cent. of PbO. The formula (C₁₂H₂₁O₁₁)₂Pb +
2(C₁₂H₂₂O₁₁) supposes 14·2 per cent. of oxide of lead.

Feronia gum repeatedly treated with fuming nitric acid produces
abundant crystals of mucic acid. We found our sample of the gum to
yield 17 per cent. of water, when dried at 110° C. It left 3·55 per
cent. of ash.


CATECHU.

_Catechu nigrum_; _Black Catechu_, _Pegu Catechu_, _Cutch_, _Terra
Japonica_; F. _Cachou_, _Cachou brun ou noir_; G. _Catechu_.

=Botanical Origin=—The trees from which this drug is manufactured are
of two species, namely:—

1. _Acacia Catechu_ Willd. (_Mimosa Catechu_ L. fil., _M. Sundra_
Roxb.[923]), a tree 30 to 40 feet high, with a short, not very straight
trunk4 to 6 feet in girth, straggling thorny branches, light feathery
foliage, and dark grey or brown bark, reddish and fibrous internally.

[922] Flückiger, _Pharm. Journ._ x. (1869). 641.

[923] Some Indian botanists, as Beddome, regard _Mimosa (Acacia)
Sundra_ as distinct from _A. Catechu._—Fig. in Bentley and Trimen, part
17.

It is common in most parts of India and Burma, where it is highly
valued for its wood, which is used for posts and for various domestic
purposes, as well as for making catechu and charcoal, while the
astringent bark serves for tanning. It also grows in the hotter and
drier parts of Ceylon. _A. Catechu_ abounds in the forests of Tropical
Eastern Africa; it is found in the Soudan, Sennaar, Abyssinia, the Noer
country, and Mozambique, but in none of these regions is any astringent
extract manufactured from its wood.

2. _A. Suma_ Kurz[924] (_Mimosa Suma_ Roxb.), a large tree with a red
heartwood, but a white bark, nearly related to the preceding but not
having so extensive a geographical range. It grows in the South of
India (Mysore), Bengal and Gujerat. The bark is used in tanning, and
catechu is made from the heartwood.

The extract of the wood of these two species of _Acacia_ is _Catechu_
in the true and original sense of the word, a substance not to be
confounded with _Gambier_, which, though very similar in composition,
is widely diverse in botanical origin, and always regarded in commerce
as a distinct article.

=History=—Barbosa in his description of the East Indies in 1514[925]
mentions a drug called _Cacho_ as an article of export from Cambay to
Malacca. This is the name for _Catechu_ in some of the languages of
Southern India.[926]

About fifty years later, Garcia de Orta gave a particular account of
the same drug[927] under its Hindustani name of _Kat_, first describing
the tree and then the method of preparing an extract from its wood.
This latter substance was at that period made up with the flour of
a cereal (_Eleusine coracana_ Gärtn.) into tablets or lozenges, and
apparently not sold in its simple state: compositions of this kind are
still met with in India. In the time of Garcia de Orta the drug was an
important article of traffic to Malacca and China, as well as to Arabia
and Persia.

Notwithstanding these accounts, catechu remained unknown in Europe
until the 17th century, when it began to be brought from Japan, or
at least said to be exported from that country. It was known about
1641 to Johannes Schröder,[928] and is quoted at nearly the same time
in several tariffs of German towns, being included in the samples of
mineral origin.[929]

[924] Brandis, _Forest Flora of North-Western and Central India_, Lond.
1874. 187, from which excellent work we also borrow the description of
_A. Catechu._

[925] Published by the Hakluyt Society, Lond. 1866. p. 191.

[926] As Tamil and Canarese, in which according to modern spelling
the word is written _Káshu_ or _Káchu_.—Moodeen Sheriff, _Suppl. to
Pharmacopœia of India_, 1879. 96.

[927] _Aromatum Historia_, ed. Clusius, 1574. 44.—He writes the word
_Cate_.

[928] _Pharmacopœia medico-physica_, Ulmæ, 1649. lib. iii. 516. “Est et
genus terræ exoticæ, colore purpureum, punctulis albis intertextum, ac
si situm contraxisset, sapore austeriusculum, masticatum liquescens,
subdulcemque post se relinquens saporem, _Catechu_ vocant, seu _Terram
japonicam_.... Particulam hujus obtinui a Pharmacopœo nostrate
curiosissimo Dn. Matthia Bansa.” The preface is dated Frankfurt A.D.
1641.

[929] _Pharm. Journ._ vi. (1876) 1022.

In 1671, catechu was noticed as a useful medicine by G. W. Wedel of
Jena,[930] who also called attention to the diversity of opinion as
to its mineral or vegetable nature. Schröck[931] in 1677 combated the
notion of its mineral origin, and gave reasons for considering it a
vegetable substance. A few years later, Cleyer,[932] who had a personal
knowledge of China, pointed out the enormous consumption of catechu for
mastication in the East,—that it is imported into Japan,—that the best
comes from Pegu, but some also from Surat, Malabar, Bengal, and Ceylon.

Catechu was received into the London Pharmacopœia of 1721, but was even
then placed among “_Terræ medicamentosæ_.”

The wholesale price in London in 1776 was £16 16_s._ per cwt.; in
1780 £20; in 1793 £14 14_s._, from which it is easy to infer that the
consumption could only have been very small.[933]

=Manufacture=—Cutch, commonly called in India _Kát_ or _Kut_, is
an aqueous extract made from the wood of the tree. The process for
preparing it varies slightly in different districts.

The tree is reckoned to be of proper age when its trunk is about a foot
in diameter. It is then cut down, and the whole of the woody part,
with the exception of the smaller branches and the bark, is chopped
into chips. Some accounts state that only the darker heartwood is thus
used. The chips are then placed with water in earthen jars, a series
of which is arranged over a mud-built fireplace, usually in the open
air. Here the water is made to boil, the liquor as it becomes thick and
strong being decanted into another vessel, in which the evaporation is
continued until the extract is sufficiently inspissated, when it is
poured into moulds made of clay, or of leaves pinned together in the
shape of cups, or in some districts on to a mat covered with the ashes
of cow-dung, the drying in each case being completed by exposure to the
sun and air. The product is a dark brown extract, which is the usual
form in which cutch is known in Europe.

In Kumaon in the north of India,[934] a slight modification of
the process affords a drug of very different appearance. Instead
of evaporating the decoction to the condition of an extract, the
inspissation is stopped at a certain point and the liquor allowed to
cool, “coagulate,” and crystallize over twigs and leaves thrown into
the pots for the purpose. How this drug is finished off we do not
exactly know, but we are told that by this process there is obtained
from each pot about 2 lb. of “_Kath_” or catechu, of an ashy whitish
appearance, which is quite in accordance with the specimens we have
received and of which we shall speak further on.

In Burma the manufacture and export of cutch form, next to the sale
of timber, the most important item of forest revenue. According to a
report by the Commissioner of the Prome Division, the trade returns
of 1869-70 show that the quantity of cutch exported from the province
during the year was 10,782 tons, valued at £193,602, of which nearly
one-half was the produce of manufactories situated in the British
territory. Vast quantities of the wood are consumed as fuel, especially
for the steamers on the Irrawadi.[935]

[930] _Usus novus Catechu seu Terræ Japonicæ,—Ephemerides Nat. Cur._
Dec. i. ann. 2 (1671) 209.

[931] _Ibid._ Dec. i. ann. 8 (1677) 88.

[932] _Ibid._ Dec. ii. ann. 4 (1685) 6.

[933] Pegu Cutch is quoted in a London price current, March 1879, £1.
2_s._ per cwt.

[934] Madden in _Journ. of Asiat. Soc. of Bengal_, xvii. part i. (1848)
565; also private communication accompanied by specimens of tree, wood,
and extract from Mr. F. E. G. Matthews, of the Kumaon Iron Works, Nynee
Tal.

[935] Pearson (G. F.) _Report of the Administration of the Forest
Department in the several provinces under the Government of India_,
1871-72, Calcutta, 1872, part 5. p. 22.

=Description=—Cutch is imported in mats, bags, or boxes. It is a dark
brown, extractiform substance, hard and brittle on the surface of the
mass, but soft and tenacious within, at least when newly imported. The
large leaf of _Dipterocarpus tuberculatus_ Roxb., the _Ein_ or _Engben_
of the Burmese, is often placed outside the blocks of extract.

Cutch when dry breaks easily, showing a shining but bubbly and slightly
granular fracture. When it is soft and is pulled out into a thin film,
it is seen to be translucent, granular and of a bright orange-brown.
When further moistened and examined under the microscope, it exhibits
an abundance of minute acicular crystals, precisely as seen in gambier.
We have observed the same in numerous samples of the dry drug when
rendered pulpy by the addition of water, or moistened with glycerin and
viewed by polarized light.

The pale cutch referred to as manufactured in the north of India, is
in the form of irregular fragments of a cake an inch or more thick,
which has a laminated structure and appears to have been deposited
in a round-bottomed vessel. It is a porous, opaque, earthly-looking
substance of a pale pinkish-brown, light, and easily broken. Under the
microscope it is seen to be a mass of needle-shaped crystals exactly
like gambier, with which in all essential points it corresponds. We
have received from India the same kind of cutch made into little
round cakes like lozenges, with apparently no addition. The taste of
cutch is astringent, followed by a sensation of sweetness by no means
disagreeable.

=Chemical Composition=—Extractiform cutch, such as that of Pegu, which
is the only sort common in Europe, when immersed in cold water turns
whitish, softens and disintegrates, a small proportion of it dissolving
and forming a deep brown solution. The insoluble part is _Catechin_
in minute acicular crystals. If a little of the thick chocolate-like
liquid made by macerating cutch in water, is heated to the boiling
point, it is rendered quite transparent (mechanical impurities being
absent), but becomes turbid on cooling. Ferric chloride forms with this
solution a dark green precipitate, immediately changing to purple if
common water or a trace of free alkali be used.

Ether extracts from cutch, catechin. This substance has been
investigated by many chemists, but as yet with discrepant results. It
agrees, according to Etti (1877), with the formula C₁₉H₁₈O₈, when dried
at 80° C. By gently heating catechin, _Catechu-tannic acid_, C₃₈H₃₄O₁₅,
is produced:

    2(C₁₉H₁₈O₈)-OH₂ = C₃₆H₃₄O₁₅.

This is an undoubted acid, readily soluble in water, of decidedly
tanning properties, precipitating also the alkaloids and albumin.
Catechu-tannic acid being the first anhydride of catechin, there
are several more substances of that class; one of them is called
_Catechuretin_. This blackish brown almost insoluble substance is
obtained by heating catechin with concentrated hydrochloric acid at
180°:

    2(C₁₉H₁₈O₈)-4 OH₂ = C₃₈H₂₈O₁₂.
Catechin, by melting it with caustic potash, affords Protocatechuic
acid, C₆H₃(OH)₂COOH, and Phloroglucin, C₆H₃(OH)₃:

    C₁₉H₁₈O₈ + 2 OH₂ = 4 H · C₇H₆O₄ · 2 C₆H₆O₃.

Gautier (1877) also obtained the two latter products, but he is of the
opinion that they are due to a somewhat different reaction, the formula
of catechin, as derived from his analyses, being C₂₁H₁₈O₈. He also
asserts that the so-called catechin from Uncaria (see Gambier) is not
identical with the substance under notice, nor with that found in the
Mahogan wood, to which Gautier assigns the formula C₄₂H₃₄O₁₆.

Crystallized deposits of catechin are sometimes met with in fissures of
the trunk of Acacia Catechu, and used medicinally in India under the
name _Keersal_.[936]

Löwe (1873), by exhausting cutch with cold water and then agitating
the solution with ether, obtained upon the evaporation of the latter a
yellow crystalline substance which he ascertained to be _Quercetin_,
C₂₇H₁₈O₁₂. Its solubility in water is probably favoured by the presence
of catechin, water having but very little action upon pure quercetin.
The amount of quercetin in cutch is exceedingly small.

When either cutch or gambier is subjected to dry distillation it
yields, in common with many other substances, _Pyrocatechin_, C₆H₄(OH)₂.

=Commerce=—The importations of cutch into the United Kingdom from
British India (excluding the Straits Settlements and Ceylon) were as
under, almost the whole being from Bengal and Burma:—

        1869       1870       1871       1872
    2257 tons.  5252 tons.  4335 tons.  5240 tons.

The total value of the cutch imported in 1872 was estimated at £124,458.

=Uses=—Cutch under the name of _Catechu_, which name it shares with
gambier, is employed in medicine as an astringent.

=Analogous Products=—See our articles Semen Arecæ and Gambier.




ROSACEÆ.


AMYGDALÆ DULCES.

_Sweet Almonds_; F. _Amandes douces_; G. _Süsse Mandeln_.

=Botanical Origin=—_Prunus Amygdalus_ Baillon[937] var. β. _dulcis_
(_Amygdalus communis_ L. var. β. _dulcis_ DC.)—The native country of
the almond cannot be ascertained with precision. A. de Candolle,[938]
after reviewing the statements of various authors concerning the
occurrence of the tree in an apparently wild state, arrives at the
conclusion that its original area possibly extended from Persia,
westward to Asia Minor and Syria, and even to Algeria. The tree
is found ascending to 4000 feet in the Antilebanon, to 3000 in
Mesopotamia, and even to 9000 feet in the Avroman range, not far from
Sulemānia, Southern Kurdistan.[939]

[936] Dymock, _Ph. Journ._ vii. (1876) 109.

[937] _Hist. des Plantes_ (_Monogr. des Rosacées_, 1869) i. 415.

[938] _Géographie Botanique_, ii. (1855) 888.

[939] Boissier, _Flora Orientalis_, ii. (1872) 641.

At an early period the tree was spread throughout the entire
Mediterranean region, and in favourable situations, far into the
continent of Europe. It was apparently introduced into Italy from
Greece, where according to Heldreich,[940] the bitter variety is truly
wild. The almond-tree matures its fruit in the south of England, but is
liable to destruction by frost in many parts of central Europe.

=History=—The earliest notice of the almond extant is that in the Book
of Genesis,[941] where we read that the patriarch Israel commanded
his sons to carry with them into Egypt a present consisting of the
productions of Palestine, one of which is named as _almonds_.

From the copious references to the almond in the writings of
Theophrastus, one cannot but conclude that in his day it was familiarly
known.

In Italy, M. Porcius Cato[942] mentions towards the middle of the
2nd century B.C. _Avellanæ Græcæ_ which we know from later authors
signified _almonds_. Columella, who wrote about A.D.. 60, calls them
_Nuces Græcæ_. Bitter almonds (“_Amygdali amari_”) are named about this
latter period by Scribonius Largus.

As to more northern Europe, almonds are mentioned together with other
groceries and spices as early as A.D. 716, in a charter granted
by Chilperic II., King of France, to the monastery of Corbie in
Normandy.[943] In 812 Charlemagne ordered the trees (_Amandalarii_)
to be introduced on the imperial farms. In the later middle ages,
the cultivation of the almond was carried on about Speier and in the
Rhenish Palatinate. We learn from Marino Sanudo[944] that in the
beginning of the 14th century, almonds had become an important item of
the Venetian trade to Alexandria. They were doubtless in large part
produced by the islands of the Greek Archipelago, then under Christian
rule. In Cyprus for instance, the Knights Templar levied tithes in 1411
of _almonds_, honey, and sesamé seed.[945]

The consumption of almonds in mediæval cookery was enormous. An
inventory made in 1372 of the effects of Jeanne d’Evreux, queen of
France, enumerates only 20 lb. of sugar, but 500 lb. of almonds.[946]

In the _Form of Cury_, a manuscript written by the master cooks of King
Richard II., A.D. 1390, are receipts for “_Creme of Almand_, _Grewel of
Almand_, _Cawdel of Almand Mylke_, _Jowt of Almand Mylke_,” &c.[947]

Almonds were sold in England by the “_hundred_” _i.e._ 108 lb.
Rogers[948] gives the average price between 1259 and 1350 as 2d., and
between 1351 and 1400 as 3⅛d. per lb.

[940] _Nutzpflanzen Griechenlands_, Athen, 1862. 67.

[941] Ch. xliii. v. 11; Num. xvii. 8.

[942] _De Re Rustica_, cap. viii.

[943] Pardessus, _Diplomata Chartæ_, etc., Paris, 1849. ii. 309.

[944] _Liber Secretorum Fidelium_, ed. Bongars, 1611. 24.

[945] De Mas Latrie, _Hist. de l’île de Chypre_, ii. (1852) 500.

[946] Leber, _Appréciation de la fortune privée au moyen-âge_, éd. 2,
Paris, 1847. 95.

[947] Published by Pegge, Lond. 1780.—Boorde in his _Dyetary of Helth_,
1542, mentions _Almon Mylke_ and _Almon Butter_, the latter “_a
commendable dysshe, specyallye in Lent_.”

[948] _Agriculture and Prices in England_, i. (1866) 641.

=Description=—The fruit of the almond tree is a drupe, with a velvety
sarcocarp which at maturity dries, splits, and drops out leaving bare
and still attached to the branch, an oblong, ovate pointed stone,
pitted with irregular holes. The seed, about an inch in length, is
ovate or oblong, more or less compressed, pointed at the upper, blunt
at the lower end, coated with a scurfy, cinnamon-brown skin or testa.
It is connected with the stone or putamen by a broad funicle, which
runs along its edge for more than a third of its length from the apex;
hence the raphe passes downwards to the rounded end of the seed, where
a scar marks the chalaza. From this, a dozen or more ramifying veins
run up the brown skin towards the pointed end. After an almond has been
macerated in warm water, the skin is easily removed, bringing with it
the closely attached translucent inner membrane or endopleura. As the
seed is without albumen, the whole mass within the testa consists of
embryo. This is formed of a pair of plano-convex cotyledons, within
which lie the flat leafy plumule and thick radicle, the latter slightly
projecting from the pointed or basal end of the seed.

Almonds have a bland, sweet, nutty flavour. When triturated with water,
they afford a pure white, milk-like emulsion of agreeable taste.

=Varieties=—The different sorts of almond vary in form and size, and
more particularly in the firmness of the shell. This in some varieties
is tender and easily broken in the hand, in others so hard as to
require a hammer to fracture it. The form and size of the kernel
likewise exhibit some variation. The most esteemed are those of Malaga,
known in trade as _Jordan Almonds_. They are usually imported without
the shell, and differ from all other sorts in their oblong form and
large size. The other kinds of sweet almonds known in the London market
are distinguished in the order of value as _Valencia_, _Sicily_, and
_Barbary_.[949]

=Microscopic Structure=—Three different parts are to be distinguished
in the brown coat of an almond. First, a layer of very large (as much
as ⅓ mm. in diameter) irregular cells, to which the scurfy surface is
due. If these brittle cells are boiled with caustic soda, they make
a brilliant object for microscopic examination in polarized light.
The two inner layers of the skin are made up of much smaller cells,
traversed by small fibro-vascular bundles. The brown coat assumes a
bluish hue on addition of perchloride of iron, owing to the presence of
tannic matter.

The cotyledons consist of thin-walled parenchyme, fibro-vascular
bundles being not decidedly developed. This tissue is loaded with
granular albuminous matter, some of which exhibits a crystalloid
aspect, as may be ascertained in polarized light. Starch is altogether
wanting in almonds.

=Chemical Composition=—The sweet almond contains fixed oil extractable
by boiling ether to the extent of 50 to 55 per cent. A produce of 50
per cent. by the hydraulic press is by no means uncommon.

The oil (_Oleum Amygdalæ_) is a thin, light yellow fluid, of sp. gr.
0·92, which does not solidify till cooled to between -10 and-20° C.
When fresh, it has a mild nutty taste, but soon becomes rancid by
exposure to the air; it is not, however, one of the drying oils. It
consists almost wholly of the glycerin compound of _Oleic Acid_,
C₁₈H₃₄O₂.

[949] To be consulted for further information: Bianca, _G. Manuale
della Cultivazione del Mandorlo in Sicilia_, Palermo, 1874 (444 pages).

Almonds easily yield to cold water a sugar tasting like honey, which
reduces alkaline cupric tartrate even in the cold, and is therefore in
part grape sugar. Pelouze however (1855) obtained from almonds 10 per
cent. of cane-sugar. The amount of gum appears to be very small; Fleury
(1865) found that the _total amount_ of sugar, dextrin and mucilage was
altogether only 6·29 per cent.

If almonds are kept for several days in alcohol, crystals of asparagine
(see article Rad. Althææ, p. 93) make their appearance, as shown by
Henschen (1872), and by Portes (1876).

The almond yields 3·7 per cent. of nitrogen, corresponding to about 24
per cent. of albuminoid matters. These have been elaborately examined
by Robiquet (1837-38), Ortloff (1846), Bull (1849), and Ritthausen
(1872).[950] The experiments tend to show that there exist in the
almond two different protein substances; Robiquet termed one of these
bodies _Synaptase_, while others applied to it the name _Emulsin_.[951]
Commaille (1866) named the second albuminous substance _Amandin_; it
is the _Almond-legumin_ of Gmelin’s _Chemistry_, the _Conglutin_ of
Ritthausen. Emulsin has not yet been freed from earthly phosphates
which, when it is precipitated by alcohol from any aqueous solution,
often amount to a third of its weight. Amandin may be precipitated
from its aqueous solution by acetic acid. According to Ritthausen,
these bodies are to be regarded as modifications of one and the same
substance, namely vegetable casein.

Blanched almonds comminuted yield, when slightly warmed with dilute
potash, a small quantity of hydrocyanic acid and of ammonia; the former
may be made manifest by means of Schönbein’s test pointed out at p. 250.

The ash of almonds, amounting to from 3 to nearly 5 per cent., consists
chiefly of phosphates of potassium, magnesium and calcium.

=Production and Commerce=—The quantity of almonds imported into the
United Kingdom in 1872 was 70,270 cwt., valued at £204,592. Of this
quantity, Morocco supplied 33,500 cwt., and Spam with the Canary
Islands 22,000 cwt., the remainder being made up by Italy, Portugal,
France, and other countries. The imports into the United Kingdom in
1876 were 77,169 cwt., valued at £244,078. Almonds are largely shipped
from the Persian Gulf: in the year 1872-73, there were imported thence
into Bombay, 15,878 cwt., besides 3,049 cwt. from other countries.[952]

=Uses=—Sweet almonds may be used for the extraction of almond oil, yet
they are but rarely so employed (at least in England) on account of the
inferior value of the residual cake. The only other use of the sweet
almond in medicine is for making the emulsion called _Mistura Amygdalæ_.


AMYGDALÆ AMARÆ.

_Bitter Almonds_; F. _Amandes amères_; G. _Bittere Mandeln_.

=Botanical Origin=—_Prunus Amygdalus_ Baillon var. _a. amara_
(_Amygdalus communis_ L. var. _a. amara_ DC.). The Bitter Almond
tree is not distinguished from the sweet by any permanent botanical
character, and its area of growth appears to be the same (see p. 244).

[950] _Die Eiweisskörper der Getreidearten, Hülsenfrüchte und
Oelsamen_, Bonn, 1872. 199.

[951] Gmelin, _Chemistry_, xviii. (1871) 452.

[952] _Statement of the Trade and Navigation of Bombay for_ 1872-73,
pt. ii. 31.

=History=—(See also preceding article.) Bitter almonds and their
poisonous properties were well known in the antiquity, and used
medicinally during the middle ages. Valerius Cordus prescribed them as
an ingredient of trochisci.[953]

As early as the beginning of the present century, it was shown by the
experiments of Bohm, a pharmaceutical assistant of Berlin, that the
aqueous distillate of bitter almonds contains hydrocyanic acid and a
peculiar oil which cannot be obtained from sweet almonds. It was then
inferred that hydrocyanic acid itself might be poisonous, a fact which,
strange to say, had not been noticed by Scheele, when he discovered
that acid in 1782, as obtained by distilling potassium ferrocyanate
with sulphuric acid. The dangerous action of hydrocyanic was then
ascertained in 1802 and 1803 by Schaub and Schrader.[954]

=Description=—Bitter almonds agree in outward appearance, form, and
structure with sweet almonds; they exist under several varieties,
but there is none so far as we know that in size and form resembles
the long sweet almond of Malaga.[955] In general, bitter almonds are
of smaller size than sweet. Triturated with water, they afford the
same white emulsion as sweet almonds, but it has a strong odour of
hydrocyanic acid and a very bitter taste.

=Varieties=—These are distinguished in their order of goodness, as
French, Sicilian, and Barbary.

=Microscopic Structure=—In this respect, no difference between sweet
and bitter almonds can be pointed out. If thin slices of the latter are
deprived of fat oil by means of benzol, and then kept for some years in
glycerin, an abundance of crystals is slowly formed, of what we suppose
to be amygdalin.

=Chemical Composition=—Bitter almonds, when comminuted and mixed with
water, immediately evolve the odour of bitter almond oil. The more
generally diffused substances are the same in both kinds of almond, and
the fixed oil in particular of the bitter almond is identical with that
of the sweet. Bitter almonds however contain on an average a somewhat
lower proportion of oil than the sweet. In one instance that has come
to our knowledge in which 28 cwt. of bitter almonds were submitted
to pressure, the yield of oil was at the rate of 43·6 per cent. Mr.
Umney, director of the laboratory of Messrs. Herrings and Co., where
large quantities of bitter almonds are submitted to powerful hydraulic
pressure, gives 44·2 as the average percentage of oil obtained during
the years 1871-2.

[953] _Dispensator_., Paris, 1548. 336. 337. 343.

[954] J. B. Richter, _Neuere Gegenstände der Chymie_, Breslau, xi.
(1802) 65. J. B. Trommsdorffs _Journ. d. Pharm._ xi. (Leipzig, 1803)
262. Preyer, _Die Blausäure_, Bonn, 1870. 152.

[955] Hence to avoid bitter almonds being used instead of sweet, the
_British Pharmacopœia_ directs that _Jordan Almonds_ alone shall be
employed for Confection of Almonds.

Robiquet and Boutron-Charland in 1830 prepared from bitter almonds a
crystalline substance, _Amygdalin_, and found that bitter almond oil
and hydrocyanic acid can no longer be obtained from bitter almonds,
the amygdalin of which has been removed by alcohol. Liebig and Wöhler
in 1837 showed that it is solely the decomposition of this body (under
conditions to be explained presently), that occasions the formation of
the two compounds above named. Disregarding secondary products (ammonia
and formic acid), the reaction takes place as represented in the
following equation:

    C₂₀H₂₇NO₁₁ + 3 OH₂ = OH₂ · 2 (C₆H₁₂O₆) · NCH · C₇H₆O.
    Crystallized               Anhydrous  Hydro- Bitter
     Amygdalin.                 Dextro-  cyanic  Almond
                                glucose.   Acid.   Oil.

This memorable investigation first brought under notice a body of the
glucoside class, now so numerous.

Amygdalin may be obtained crystallized when almonds deprived of their
oil are boiled with alcohol of 84 to 94 per cent. The product amounts
at most to 2½ or 3 per cent. Amygdalin _per se_ dissolves in 15 parts
of water at 8-12° C., forming a neutral, bitter, inodorous liquid,
quite destitute of poisonous properties.

It would appear from the investigations of Portes (1877) that in young
almonds, amygdalin is formed before the emulsin.

When bitter almonds have been freed from amygdalin and fixed oil, cold
water extracts from the residue chiefly emulsin and another albuminoid
matter separable by acetic acid. The emulsin upon addition of alcohol
falls down in thick flocks, which, after draining, form with cold
water a slightly opalescent solution. This liquid added to an aqueous
solution of amygdalin, renders it turbid, and developes in it bitter
almond oil. The reaction takes place in the same manner, if the emulsin
has not been previously purified by acetic acid and alcohol, or if
an emulsion of sweet almonds used. But after boiling, an emulsion of
almonds is no longer capable of decomposing amygdalin.

What alteration the emulsin itself undergoes in this reaction, or
whether it suffers any alteration at all, has not been clearly made
out. The reaction does not appear to take place necessarily in atomic
proportions; it does not cease until the emulsin has decomposed
about three times its own weight of amygdalin, provided always that
sufficient water is present to hold all the products in solution.

The leaves of _Prunus Lauro-cerasus_ L., the bark of _P. Padus_ L., and
the organs of many allied plants, also contain emulsin or a substance
analogous to it, not yet isolated. In the seeds of various plants
belonging to natural orders not botanically allied to the almond, as
for example in those of mustard, hemp, and poppy, and even in yolk
of egg, albuminous substances occur which are capable of acting upon
amygdalin in the same manner. Boiling dilute hydrochloric acid induces
the same decomposition, with the simultaneous production of formic acid.

The distillation of bitter almonds is known to offer some difficulties
on account of the large quantity present of albuminous substances,
which give rise to bumping and frothing. Michael Pettenkofer (1861) has
found that these inconveniences may be avoided by immersing 12 parts
of powdered almonds in boiling water, whereby the albuminous matters
are coagulated, whereas the amygdalin is dissolved. On then adding
an emulsion of only 1 part of almonds (sweet or bitter), the emulsin
contained in it will suffice to effect the required decomposition at a
temperature not exceeding 40° C. In this manner, Pettenkofer obtained
in some experiments performed with small quantities of almonds, as
much as 0·9 per cent. of essential oil. In the case alluded to on
the opposite page, in which 28 cwt. of almonds were treated, the
yield of essential oil amounted to 0·87 per cent. From data obligingly
furnished to us by Messrs. Herrings and Co. of London, who distill
large quantities of almond cake, it appears that the yield of essential
oil is very variable. The yearly averages as taken from the books of
this firm, show that it may be as low as 0·74, or as high as 1·67 per
cent., which, assuming 57 pounds of cake as equivalent to 100 pounds of
almonds, would represent a percentage from the latter of 0·42 and 0·95
per cent. respectively. Mr. Umney explains this enormous variation as
due in part to natural variableness in the different kinds of bitter
almond, and in part to their admixture with sweet almonds. He also
states that the action of the emulsin on the amygdalin when in contact
with water, is extremely rapid, and that 200 pounds of almond marc are
thoroughly exhausted by a distillation of only three hours.

In the distillation, the hydrocyanic acid and bitter almond oil unite
into an unstable compound. From this, the acid is gradually set
free, and partly converted into cyanide of ammonium and formic acid.
Supposing bitter almonds to contain 3·3 per cent. of Amygdalin, they
must yield 0·2 per cent. of hydrocyanic acid. Pettenkofer obtained by
experiment as much as 0·25 per cent., Feldhaus (1863) 0·17 per cent.

Some manufacturers apply bitter almond oil deprived of hydrocyanic
acid, but such purified oil is very prone to oxidation, unless
carefully deprived of water by being shaken with fused chloride of
calcium. The sp. gr. of the original oil is 1·061-1·065; that of the
purified oil (according to Umney) 1·049. The purification by the action
of ferrous sulphate and lime, and re-distillation, as recommended by
Maclagan (1853), occasions, we are informed, a loss of about 10 per
cent.

Bitter almond oil, C₆H₅(COH), being the aldehyde of benzoic acid,
C₆H₅(COOH), is easily converted in that acid by spontaneous or
artificial oxidation. The oil boils at 180°C. and is a little soluble
in water; 300 parts of water dissolve one part of the oil.

There are a great number of plants which if crushed, moistened with
water, and submitted to distillation, yield both bitter almond oil and
hydrocyanic acid. In many instances the amount of hydrocyanic acid is
so extremely small, that its presence can only be revealed by the most
delicate test,—that of Schönbein.[956]

Among plants capable of emitting hydrocyanic acid, probably always
accompanied with bitter almond oil, the tribes _Pruneæ_ and _Pomeæ_ of
the rosaceous order may be particularly mentioned.

The farinaceous rootstocks of the Bitter Cassava, _Manihot utilissima_,
Pohl, of the order _Euphorbiaceæ_, the source of tapioca in Brazil,
have long been known to yield hydrocyanic acid.

A composite, _Chardinia xeranthemoides_ Desf., growing in the Caspian
regions, has been shown by W. Eichler also to emit hydrocyanic
acid.[957] The same has been observed by the French in Gaboon[958] with
regard to the fruits of _Ximenia americana_ L. of the order _Olacineæ_,
and the fact has been confirmed by Ernst of Caracas,[959] near which
place the plant abounds. Mr. Prestoe of the Botanical Garden, Trinidad,
informs us (1874) that in that island a convolvulaceous plant, _Ipomœa
dissecta_ Willd., contains a juice with a strong prussic acid odour.
According to Lösecke, a common mushroom, _Agaricus oreades_ Bolt.,
emits hydrocyanic acid.[960]

[956] Applied in the following manner:—Let bibulous paper be imbued
with a fresh tincture of the wood or resin of guaiacum, and after
drying, let it be moistened with a solution composed of one part of
sulphate of copper in 2000 of water. Such paper moistened with water
will assume an intense blue coloration in the presence of hydrocyanic
acid.

[957] _Bull. de la Soc. imp. des nat. de Moscou_, xxxv. (1862) ii. 444.

[958] Exposition Univers. de 1867.—_Produits des Colonies Françaises_,
92.

[959] _Archiv der Pharmacie_, 181 (1867) 222.

[960] _Jahresbericht_ of Wiggers and Husemann for 1871. 11.

This acid is consequently widely diffused throughout the vegetable
kingdom. Yet amygdalin has thus far only been isolated from a few
plants belonging to the genus _Prunus_ or its near allies.[961] In
all other plants in which hydrocyanic acid has been met with, we know
nothing as to its origin. Ritthausen and Kreusler (1871) have proved
the _absence_ of amygdalin in the seeds of a _Vicia_, which yield
bitter almond oil and hydrocyanic acid. These chemists followed the
process which in the case of bitter almonds easily affords amygdalin.

=Commerce=—See preceding article.

=Uses=—Bitter almonds are used almost exclusively for the manufacture
of _Almond Oil_, while from the residual cake is distilled _Bitter
Almond Oil_. An emulsion of bitter almonds is sometimes prescribed as a
lotion.

=Adulteration=—The adulteration of bitter almonds with sweet is a
frequent source of loss and annoyance to the pressers of almond oil,
whose profit largely depends on the amount of volatile oil they are
able to extract from the residual cake.


FRUCTUS PRUNI.

_Prunes_; F. _Pruneaux à médecine_.

=Botanical Origin=—_Prunus domestica_ L., var. ζ. _Juliana_ DC.—It is
from this tree, which is known as _Prunier de St. Julien_,[962] that
the true _Medicinal Prunes_ of English pharmacy are derived. The tree
is largely cultivated in the valley of the Loire in France, especially
about Bourgueil, a small town lying between Tours and Angers.

=History=—The plum-tree (_P. domestica_ L.) from which it is supposed
the numerous cultivated varieties have descended, is believed to occur
in a truly wild state in Greece, the south-eastern shores of the Black
Sea (Lazistan), the Caucasus, and the Elburz range in Northern Persia,
from some of which countries it was introduced into Europe long before
the Christian era. In the days of Pliny, numerous species of plum were
already in cultivation, one of which afforded a fruit having laxative
properties.

Dried prunes, especially those taking their name from Damascus (_Pruna
Damascena_), are frequently mentioned in the writings of the Greek
physicians, by whom as well as at a later period by the practitioners
of the Schola Salernitana, they were much employed.

[961] Gmelin, _Chemistry_, vii. 389; xv. 422.

[962] Loiseleur-Deslongchamps et Michel, _Nouveau Duhamel, ou Traité
des arbres et arbustes que l’on cultive en France_, v. (1812) 189, pl.
54. fig. 2, pl. 56. fig. 9.

In the older London pharmacopœias, many sorts of plum are enumerated,
but in the reformed editions of 1746, 1788, and 1809, the French Prune
(_Prunum Gallicum_) is specially ordered, its chief use being as an
ingredient of the well-known _Lenitive Electuary_; and this fruit
is still held by the grocers to be the legitimate _prune_. The same
variety is regarded in France as the prune of medicine.

=Description=—The prune in its fresh state is an ovoid drupe of a deep
purple hue, not depressed at the insertion of the stalk, and with
a scarcely visible suture, and no furrow. The pulp is greenish and
rather austere, unless the fruit is very ripe; it does not adhere to
the stone. The stone is short (⁷/₁₀ to ⁸/₁₀ of an inch long, ⁵/₁₀ to
⁶/₁₀ broad), broadly rounded at the upper end and slightly mucronulate,
narrowed somewhat stalk-like at the lower, and truncate; the ventral
suture is broader and thicker than the dorsal.

The fruit is dried partly by solar and partly by fire-heat, that is to
say, it is exposed alternately to the heat of an oven and to the open
air. Thus prepared, it is about 1¼ inches long, black and shrivelled,
but recovers its original size and form by digestion in warm water.
The dried pulp or sarcocarp is brown and tough, with an acidulous,
saccharine, fruity taste.

=Microscopic Structure=—The skin of the prune is formed of small,
densely packed cells, loaded with a dark solid substance; the pulp
consists of larger shrunken cells, containing a brownish amorphous mass
which is probably rich in sugar. This latter tissue is traversed by a
few thin fibro-vascular bundles, and exhibits here and there crystals
of oxalate of calcium. By perchloride of iron, the cell-walls, as well
as the contents of the cells, acquire a dingy greenish hue.

=Chemical Composition=—We are not aware of any analysis having been
made of the particular sort of plum under notice, nor that any attempt
has been made to discover the source of the medicinal property it is
reputed to possess. Some nearly allied varieties have been submitted
to analysis in the laboratory of Fresenius, and shown to contain
saccharine matters to the extent of 17 to 35 per cent., besides malic
acid, and albuminoid and pectic substances.[963]

=Uses=—The only pharmaceutical preparation of which the pulp of prunes
is an ingredient, is _Confectio Sennæ_, the _Electuarium lenitivum_ of
the old pharmacopœias. The fruit stewed and sweetened is often used as
a domestic laxative.

=Substitute=—When French prunes are scarce, a very similar fruit,
known in Germany as _Zwetschen_ or _Quetschen_, is imported as a
substitute.[964] It is the produce of a tree which most botanists
regard as a form of _Prunus domestica_ L., termed by De Candolle var.
_Pruneauliana_. K. Koch,[965] however, is decidedly of opinion that it
is a distinct species, and as such he has revived for it Borkhausen’s
name of _Prunus œconomica_. The tree is widely cultivated in Germany
for the sake of its fruit, which is used in the dried state as an
article of food, but is not grown in England.

[963] Liebig’s _Ann. der Chemie_, ci. (1857) 228.

[964] This was especially the case in the winter of 1873-74.

[965] _Dendrologie_, part i. (1869) 94.

The dried fruit differs slightly from the ordinary prune in being
rather larger and more elongated, and having a thicker skin; also
in the stone being flatter, narrower, pointed at either end, with
the ventral suture much more strongly curved than the dorsal. The
fruits seem rather more prone to become covered with a saccharine
efflorescence.


CORTEX PRUNI SEROTINÆ.

_Cortex Pruni Virginianæ_; _Wild Black Cherry Bark_.

=Botanical Origin=—_Prunus serotina_ Ehrhart (_P. virginiana_ Miller
non Linn., _Cerasus serotina_ DC.)—A shrub or tree, in favourable
situations growing to a height of 60 feet, distributed over an immense
extent of North America. It is found throughout Canada as far as 62°
N. lat., and from Newfoundland and Hudson’s Bay in the east, to the
valleys west of the Rocky Mountains.[966] It is also common in the
United States.

The tree is often confounded with _P. virginiana_ L., from which,
indeed, it seems to be separated by no fixed character, though American
botanists hold the two plants as distinct. It is also nearly allied to
the well-known _P. Padus_ L. of Europe, the bark of which had formerly
a place in the Materia Medica.

=History=—Experiments on the medicinal value of Wild Cherry Bark were
made in America about the end of the last century, at which time
the drug was supposed to be useful in intermittent fevers.[967] The
bark was introduced into the _United States Pharmacopœia_ in 1820.
An elaborate article by Bentley[968] published in 1863 contributed
to bring it into notice in this country, but it is still much more
employed in America than with us.

=Description=—The inner bark of the root or branches is said to be the
most suitable for medicinal use. That which we have seen is evidently
from the latter; it is in flattish or channelled pieces, ⅒ to ¹/₂₀ of
an inch in thickness, ½ an inch to 2 inches broad, and seldom exceeding
5 inches in length. From many of the pieces, the outer suberous coat
has been shaved off, in which case the whole bark is of a deep cinnamon
brown; in others the corky layer remains, exhibiting a polished satiny
surface, marked with long transverse scars. The inner surface is finely
striated, or minutely fissured and reticulated. The bark breaks easily
with a short granular fracture; it is nearly without smell, but if
reduced to coarse powder and wetted with water it evolves a pleasant
odour of bitter almonds. It has a decided but transient bitter taste.

The bark freshly cut from the stem is quite white, and has a strong
odour of bitter almonds and hydrocyanic acid.

[966] Hooker, _Flora Boreali-Americana_, i. (1833) 169.

[967] Schöpf, _Materia Medica Americana_, Erlangæ 1787; 77.—Also
Barton, _Collections for Mat. Med. of U.S._, Philad. 1798. 11.

[968] _Pharm. Journ._ v. (1864) 67.—Also Bentley and Trimen, _Med.
Plants_, part 3; (1878).

=Microscopic Structure=—The chief mass of the tissue is made up of
hard, thick-walled, white cells, the groups of which are separated
by a brown fibrous prosenchyme. The liber is crossed in a radial
direction by numerous broad medullary rays of the usual structure. The
parenchymatous portion is loaded both with very large single crystals,
and crystalline tufts of calcium oxalate. There is also an abundance
of small starch granules, and brown particles of tannic matters.
Thin slices of the bark moistened with perchloride of iron, assume a
blackish coloration.

=Chemical Composition=—The bitterness and odour of the fresh bark
depend no doubt on the presence of a substance analogous to amygdalin,
which has not yet been examined. Hydrocyanic acid and essential oil are
produced when the bark is distilled with water, and must be due to the
mutual action of that substance alluded to, and some principle of the
nature of emulsin. From the fact that an extract of the bark remained
bitter although the whole of the essential oil and hydrocyanic acid had
been removed, Proctor inferred the existence of another substance to
which the tonic properties of the bark are perhaps due.

The fresh bark was found by Perot[969] to yield ½ per mille of
hydrocyanic acid in April, 1 per mille in June, and 1·4 in October. The
best time for collecting the bark is therefore the autumn.

=Uses=—In America, wild cherry bark is held in high estimation for
its mildly tonic and sedative properties. It is administered most
appropriately in the form of cold infusion or syrup, the latter being
a strong cold infusion, sweetened; a fluid extract and a dry resinoid
extract are also in use. The bark is said to deteriorate by keeping,
and should be preferred when recently dried.


FOLIA LAURO-CERASI.

_Common Laurel or Cherry-laurel Leaves_; F. _Feuilles de
Laurier-cerise_; G. _Kirschlorbeerblätter_.

=Botanical Origin=—_Prunus Lauro-cerasus_ L., a handsome evergreen
shrub, growing to the height of 18 or more feet, is a native of the
Caucasian provinces of Russia (Mingrelia, Imeritia, Guriel), of the
valleys of North-western Asia Minor, and Northern Persia. It has been
introduced as a plant of ornament into all the more temperate regions
of Europe, and flourishes well in England and other parts, where the
winter is not severe and the summer not excessively hot and dry.

=History=—Pierre Belon, the French naturalist, who travelled in
the East between 1546 and 1550, is stated by Clusius[970] to have
discovered the cherry-laurel in the neighbourhood of Trebizond. Thirty
years later, Clusius himself obtained the plant through the Imperial
ambassador at Constantinople, and distributed it from Vienna to the
gardens of Germany. Since it is mentioned by Gerarde[971] as a choice
garden shrub, it must have been cultivated in England prior to 1597.
Ray,[972] who like Gerarde calls the plant _Cherry-bay_, states that it
is not known to possess medicinal properties.

[969] _Pharm. Journ._ xviii (1852) 109.

[970] _Rariorum Plantarum Historia_, 1601. 4.

[971] _Herball_ (1636) 1603.

[972] _Hist. Plant._ ii. (1693) 1549.

In 1731, Madden of Dublin drew the attention of the Royal Society of
London[973] to some cases of poisoning that had occurred by the use of
a distilled water of the leaves. This water he states had been for many
years in frequent use in Ireland among cooks, for flavouring puddings
and creams, and also much in vogue with dram drinkers as an addition to
brandy, without any ill effects from it having been noticed. The fatal
cases thus brought forward occasioned much investigation, but the true
nature of the poison was not understood till pointed out by Schrader in
1803 (see art. Amygdalæ amaræ, p. 248, note 2). Cherry-laurel water,
though long used on the Continent, has never been much prescribed in
Great Britain, and had no place in any British Pharmacopœia till 1839.

=Description=—The leaves are alternate, simple, of leathery texture
and shining upper surface, 5 to 6 inches long by 1¾ to 2 inches wide,
oblong or slightly obovate, attenuated towards either end. The thick
leafstalk, scarcely half an inch in length, is prolonged as a stout
midrib to the recurved apex. The margin, which is also recurved, is
provided with sharp but very short serratures, and glandular teeth,
which become more distant towards the base. The under side, which is of
a paler colour and dull surface, is marked by 8 or 10 lateral veins,
anastomosing towards the edge. Below the lower of these and close to
the midrib, are from two to four shallow depressions or _glands_, which
in spring exude a saccharine matter, and soon assume a brownish colour.
By the glands with which the teeth of the serratures are provided, a
rather resinous substance is secreted.[974]

The fresh leaves are inodorous until they are bruised or torn, when
they instantly emit the smell of bitter almond oil and hydrocyanic
acid. When chewed they taste rough, aromatic and bitter.

=Microscopic Structure=—The upper surface of the leaf is constituted of
thin cuticle and the epidermis made up of large, nearly cubic cells.
The middle layer of the interior tissue exhibits densely packed small
cells, whereas the prevailing part of the whole tissue is formed of
larger, loose cells. Most of them are loaded with chlorophyll; some
enclose crystals of oxalate of calcium.

=Chemical Composition=—The leaves when cut to pieces and submitted to
distillation with water, yield _Bitter Almond Oil_ and _Hydrocyanic
Acid_, produced by the decomposition of _Laurocerasin_. This is
an amorphous yellowish substance isolated by Lehmann (1874) in
Dragendorff’s laboratory. He extracted the leaves with boiling alcohol,
and purified the liquid by gently warming it with hydroxide of lead.
From the liquid, crude laurocerasin was precipitated on addition of
ether; it was again dissolved repeatedly in alcohol and precipitated
by ether. The yield of the leaves is about 1⅓ per cent. Laurocerasin
is readily soluble in water, the solution deviates the plane of
polarization to the left, yet not to the same amount as amygdalin. The
molecule of laurocerasin, C₄₀H₆₇NO₃₀, would appear to include those of
amygdalin, C₂₀H₂₇NO₁₁, amygdalic acid, C₂₀H₂₆O₁₂ and 7 OH₂.

[973] _Phil. Trans._ xxxvii. (for 1731-32) 84.

[974] Reinke, in Pringsheim’s _Jahrbücher für wissenschaftliche
Botanik_, x. (1875) 129.

The proportion of hydrocyanic acid in the distilled water of the leaves
has been the subject of many researches. Among the later are those of
Broeker (1867), who distilled a given weight of the leaves grown in
Holland under precisely similar circumstances, in each month of the
year. The results proved that the product obtained during the winter
and early spring was weaker in the acid in the proportion of 17 to
24, 28, or 30, the strongest water being that distilled in July and
August. This chemist found that a stronger product was got when the
leaves were chopped fine, than when they were used whole. According
to Christison,[975] the buds and very young leaves yield ten times as
much essential oil as the leaves one year old. We have ascertained that
leaves collected in January when they were thoroughly frozen yielded a
distillate containing about ten times less of hydrocyanic acid than in
summer. The product obtained from the leaves collected in January, but
previously dried for several days at 100° C. (212° F.), still proved to
contain both essential oil and hydrocyanic acid.

The unwounded leaves of the cherry-laurel in vigorous vegetation have
been shown by our friend Prof. Schaer, not to evolve naturally a trace
of hydrocyanic acid, though they yield it on the slightest puncture.
We are ignorant of the mode of distribution in the living tissue of
the laurocerasin, and of the substances causing its decomposition, and
how these two bodies are packed so as to prevent the slightest mutual
reaction. The leaves may be even dried at 100° C. and powdered without
the evolution of any odour of hydrocyanic acid, but the latter is at
once developed by the addition of a little water; on distilling its
presence is proved by means of all the usual tests in the first drops
of the product.

Besides the substances concerned in the production of the essential
oil, the leaves contain sugar which reduces cupric oxide in the cold,
a small quantity of an iron-greening tannin, and a fatty or waxy
substance.

Schoonbroodt (1868) treated the aqueous extract of the fresh leaves
with alcoholic ether, which yielded ¼ per mille of bitter, acicular
crystals; these quickly reduced cupric oxide, losing their bitterness.

Bougarel (1877) isolated from the leaves under notice and several
others, _Phyllinic acid_, a crystalline powder melting at 170° C.

=Uses=—The leaves are only employed for making cherry-laurel water
(_Aqua Lauro-cerasi_), the use of which in England is generally
superseded by that of the more definite hydrocyanic acid.


FLORES KOSO.

_Flores Brayeræ_, _Cusso_, _Kousso_, _Kosso_.

=Botanical Origin=—_Hagenia abyssinica_ Willd. (_Brayera
anthelminthica_ Kunth), a handsome tree growing to a height of 60 feet,
found throughout the entire table-land of Abyssinia at an elevation of
3,000 to 8,000 feet above the sea-level.[976] We have never noticed
it growing in any botanic garden. The tree[977] is remarkable for its
abundant foliage and fine panicles of flowers, and is generally planted
about the Abyssinian villages.

[975] _Dispensatory_, 1842. 592.

[976] The French section of the International African Association
contributed Kousso from _Madagascar_ to the Paris Exhibition of 1878.

[977] Fig. in Bentley and Trimen, _Med. Plants_, part 5 (1876).

=History=—The celebrated Bruce[978] during his journey to discover
the source of the Nile, 1768-1773, found the koso tree in Abyssinia,
observed the uses made of it by the natives, and published a figure
of it in the narrative of his travels. It was also described in 1799
by Willdenow who called it _Hagenia_ in honour of Dr. K. G. Hagen of
Königsberg.

The anthelmintic virtues of koso were investigated by Brayer, a French
physician of Constantinople, to which place parcels of the drug are
occasionally brought by way of Egypt, and he published a small pamphlet
on the subject.[979] Several scattered notices of koso appeared in
1839-41, but no supply of it reached Europe until about 1850, when a
Frenchman who had been in Abyssinia obtained a large stock (1,400 lb.,
it was said), a portion of which he endeavoured to sell in London at
35_s._ _per ounce_! The absurd value set upon the drug produced the
usual result: large quantities were imported, and the price gradually
fell to 3_s._ or 4_s._ per lb. Koso was admitted a place in the British
Pharmacopœia of 1864.

=Description=—The flowers grow in broad panicles, 10 to 12 inches in
length. They are unisexual, but though male and female occur on the
same tree, the latter are chiefly collected. The panicles are either
loosely dried, often including a portion of stalk and sometimes a leaf,
or they are made into cylindrical rolls, kept in form by transverse
ligatures. Very often the panicles arrive quite broken up, and with
the flowers in a very fragmentary state. They have a herby, somewhat
tea-like smell, and a bitterish acrid taste.

The panicle consists of a zigzag stalk, which with its many branches
is clothed with shaggy simple hairs, and also dotted over with minute
stalked glands; it is provided at each ramification with a large
sheathing bract. At the base of each flower are two or three rounded
veiny membranous bracts, between which is the turbinate hairy calyx,
having ten sepals arranged in a double series. In the male, the outer
series consists of much smaller sepals than the inner; in the female,
the outer in the ultimate development become enlarged, obovate and
spreading, so that the whole flower measures fully ½ an inch across.
In both, the sepals are veiny and leaf-like. The petals are minute and
linear, inserted with the stamens in the throat of the calyx. These
latter are 10 to 25 in number, with anthers in the female flower,
effete. The carpels are two, included in the calycinal tube; and each
surmounted by a hairy style. The fruit is an obovate one-seeded nut.

Koso as seen in commerce has a light brown hue, with a reddish tinge
in the case of the female flowers, so that panicles of the latter are
sometimes distinguished as _Red Koso_.

[978] Travels, v. (1790) 73.

[979] _Notice sur une nouvelle plante de la famille des Rosacées,
employée contre le Tænia_, Paris, 1822. The reader should also consult
the excellent notice by Pereira written when the drug was first
offered for sale in London. _Pharm. Journ._ x. (1851) 15; reprinted
in Pereira’s _Elem. of Mat. Med._ ii. part 2 (1853) 1815.—Also
Meyer-Ahrens, _Die Blüthen des Kossobaumes_, Zürich, 1851. 90 pp.

=Chemical Composition=—Wittstein (1840) found in koso, together with
the substances common to most vegetables (wax, sugar, and gum), 24 per
cent. of tannin, and 6·25 of an acrid bitter resin, which was observed
by Harms (1857) to possess acid properties.

The researches of Pavesi (1858), and still more those of Bedall[980]
have made us acquainted with the active principle of the drug, which
has been named _Koussin_ or _Kosin_. It may be obtained by mixing the
flowers with lime, exhausting them with alcohol and then with water;
the solutions mixed, concentrated, and treated with acetic acid,
deposit the kosin. We are indebted to Dr. Bedall for a specimen of it,
which we find to consist chiefly of an amorphous, resinoid substance,
from which we got a few yellow crystals by means of glacial acetic acid.

Mr. Merck favoured us with kosin prepared in his laboratory at
Darmstadt. It is a tasteless substance of a yellow colour, forming fine
crystals of the rhombic system,—readily soluble in benzol, bisulphide
of carbon, chloroform or ether, less freely in glacial acetic acid,
and insoluble in water. We found a solution of kosin in 20 parts of
chloroform to be destitute of rotatory power. Of alcohol, sp. gr.
0·818, 1000 parts dissolve at 12° C. only 2·3 parts of this kosin.
It is abundantly soluble in alkalis, caustic or carbonated, yet has
nevertheless no acid reaction, and may be precipitated from these
solutions by an acid without having undergone any alteration. It is
then however a white amorphous mass, which yields the original yellow
crystals by re-solution in boiling alcohol, in which it dissolves
readily. The analysis which we have performed of kosin assigns it the
formula C₃₁H₃₈O₁₀.

Kosin fuses at 142° C., and remains after cooling an amorphous,
transparent yellow mass; but if touched with alcohol, it immediately
assumes the form of stellate tufts of crystals. This may be repeated at
pleasure, kosin not being altered by cautious fusion.

Kosin is not decomposed by boiling dilute acids. It dissolves in strong
sulphuric acid, giving a yellow solution which becomes turbid by the
addition of water, white amorphous kosin being thrown down. At the
same time a well-marked odour exactly like that of Locust Beans, due
to isobutyric acid, CH₃·CH₃·CH·COOH, is evolved. It would thus appear
that in all probability kosin is a compound ether of that acid. It is
very remarkable that the active principle of fern root, the filicic
acid (see Rhizoma Filicis), by decomposition yields butyric acid. If
the sulphuric solution of kosin is allowed to stand for a week, it
gradually assumes a fine red; and then yields, on addition of much
water, an amorphous red mass which after drying is not soluble in
bisulphide of carbon, and may thus be purified. We have not succeeded
in obtaining this red derivative of kosin in a crystalline state.[981]

In its anthelmintic action, kosin is nearly allied with filicic
acid.[982]

Distillation with water separates from the flowers of koso a
stearoptene-like oil having the odour of koso, and traces of valerianic
and acetic acid. No such body as the _Hagenic Acid_ of Viale and Latini
(1852) could be detected by Bedall.

=Commerce=—Koso is brought to England by way of Aden or Bombay; some
appears also to reach Leghorn, probably carried thither direct from
Egypt.

[980] Wittstein’s _Vierteljahresschrift für prakt. Pharm._ viii. (1859)
481; xi. (1862) 207.

[981] Flückiger and Buri, _Yearbook of Ph._ 1875. 19.

[982] Buchheim, _Archiv der Pharmacie, 208_ (1876) 417.

=Uses=—The drug is employed solely as a vermifuge, and is effectual for
the expulsion both of _Tænia solium_ and of _Bothriocephalus latus_.
The Abyssinian practice is to administer the flowers in substance in
a very ample dose, which is sometimes attended with alarming and even
fatal results.

The notion that the action of the drug is partially mechanical and
due to the hairs of the plant, prevails in England, and has led to
the use of an _unstrained_ infusion of the coarsely powdered flowers.
This remedy, from the quantity of branny powder (2 to 4 drachms) that
has to be swallowed, is far from agreeable; and as it occasions strong
purgation and sometimes vomiting, it is not often prescribed.[983]

The fruit of the koso tree, a small indehiscent achene, is stated by
M. Th. von Heuglin[984] to act even more powerful than the flowers;
he calls it (or the seed?) Kosála. It would appear that the fruits
have been used as an anthelmintic two centuries ago in Abyssinia.[985]
Dragendorff (1878) found them to be rich in fatty matters, but devoid
of an alkaloid.


PETALA ROSÆ GALLICÆ.

_Flores Rosæ rubræ_; _Red Rose Petals_, _Rose Leaves_, _True Provins
Roses_; F. _Pétales de Roses rouges_, _Roses de Provins_; G.
_Essigrosenblätter_.

=Botanical Origin=—_Rosa gallica_ L., a low-growing bush, with a
creeping rhizome throwing up numerous stems. The wild form with single
flowers occurs here and there in the warmer parts of Europe,[986]
including Central and Southern Russia, and Greece; also in Asia Minor,
Armenia, Kurdistan, and the Caucasus. But the plant passes into so many
varieties, and has from a remote period been so widely cultivated, that
its distribution cannot be ascertained with any exactness. As a garden
plant it exists under a multitude of forms.

=History=—The use in medicine of the rose dates from a very remote
period. Theophrastus[987] speaks of roses being of many kinds,
including some with double flowers which were the most fragrant; and
he also alludes to their use in the healing art. Succeeding writers
of every age down to a recent period have discussed the virtues of
the rose,[988] which however is scarcely now admitted to possess any
special medicinal property.

[983] Johnston in his _Travels in Southern Abyssinia_ (1844), speaking
of koso, says its effects are “_dreadfully severe_.”—Even in Abyssinia,
he adds, it is barely tolerated, and if any other remedy equally
efficient for dislodging tapeworm were to be introduced, koso would be
soon abandoned.

[984] _Reise nach Abessinien_, etc. Jena, 1868. 322.

[985] Jobi Ludolfi _Historia æthiopica_, Francofurti, 1681. lib. i.
cap. ix.

[986] It has been found in _quasi_-wild state at Charlwood in
Surrey.—_Seemann’s Journ. of Bot._ ix. (1871) 273.

[987] _Hist. Plant._ lib. vi. c. 6.

[988] Consult in particular the learned essay of D’Orbessan contained
in his _Mélanges historiques_, ii. (1768) 297-337.

One of the varieties of _R. gallica_ is the _Provins Rose_, so called
from having been long cultivated at Provins, a small town about 60
miles south-east of Paris, where it is said to have been introduced
from the East by Thibaut VI., Count of Champagne, on his return
from the Crusades, A.D. 1241. But it appears that he went then to
Navarre and in later times never resided in the Champagne. Be this as
it may, Provins became much celebrated not only for its dried rose
petals, but also for the conserve, syrup and honey of roses made
from them,—compositions which were regarded in the light of valuable
medicines.[989]

It is recorded that when, in A.D. 1310, Philippe de Marigny, archbishop
of Sens, made a solemn entry into Provins, he was presented by the
notables of the town with wine, spices, and _Conserve of Roses_; and
presents of dried roses and of the conserve were not considered beneath
the notice of Catherine de Medicis, and of Henry IV.[990]

We find that Charles Estienne, in 1536, mentions both the _Rosæ
purpureæ odoratissimæ_, which he says are called _Provinciales_, and
those known to the druggists as _incarnatæ_,—the latter we presume a
_pale_ rose.[991] _Rosæ rubeæ_ are named as an ingredient of various
compound medicines by Valerius Cordus.[992]

=Production=—The flowers are gathered while in bud and just before
expansion, and the petals are cut off near the base, leaving the paler
claws attached to the calyx. They are then carefully and rapidly dried
by the heat of a stove, and having been gently sifted to remove loose
stamens, are ready for sale. In some districts the petals are dried
entire, but the drug thus produced is not so nice.

In England, the Red Rose is cultivated at Mitcham, though now only to
the extent of about 10 acres. It is also grown for druggists’ use in
Oxfordshire and Derbyshire. At Mitcham, it is now called _Damask Rose_,
which is by no means a correct name. The English dried roses command a
high price.

There is a much more extensive cultivation of this rose on the
continent at Wassenaar and Noordwijk in Holland; in the vicinity of
Hamburg and Nuremberg in Germany, and in the villages round Paris and
Lyons. Roses are still, we believe, grown for medicinal use at Provins,
but are no longer held in great esteem.

There appears to be a considerable production of dried roses in Persia,
judging from the fact that in the year 1871-72, 1163 cwt. were exported
from the Persian Gulf to Bombay.[993]

=Description=—The petals adhere together loosely in the form of little
cones, or are more or less crumpled and separate. When well preserved,
they are crisp and dry, with a velvety surface of an intense purplish
crimson, a delicious rosy odour, and a mildly astringent taste. The
white basal portion of the petals should be nearly absent. For making
the confection, the petals are required in a fresh state.

=Chemical Composition=—Red rose petals impart to ether, without losing
their colour, a soft yellow substance, which is a mixture of a solid
fat and _Quercitrin_. Filhol has shown (1864) that it is the latter
body, and not tannic acid, of which the petals contain but a trace,
that produces the dark greenish precipitate with ferric salts. The same
chemist found in the petals 20 per cent. (?) of glucose which, together
with colouring matter and gallic acid, is extracted by alcohol after
exhaustion by ether. According to Rochleder (1867), the gallic acid in
red roses is accompanied by querci-tannic acid.

[989] Pomet, _Hist. des Drogues_, 1694, part i. 174-177, speaks of the
roses of Provins being “hautes en couleur, c’est à dire d’un rouge
noir, velouté ... très astringentes.”

[990] Assier, _Légendes, curiosités et traditions de la Champagne et de
la Brie_, Paris. 1860. 191.

[991] Stephanus (Carolus), _De re hortens libellus_, Paris, 1536. 29
(in Brit. Mus.).

[992] _Dispensatorium_, 1548. 39. 52.

[993] _Statement of the Trade and Navigation of the Presidency of
Bombay for_ 1871-72, pt. ii. 43.

The colouring matter which is so striking a constituent of the petals,
is according to Senier an acid, which appears to form crystallizable
salts with potassium and sodium.[994] An infusion of the petals is pale
red, but becomes immediately of a deep and brilliant crimson if we add
to it an acid, such as sulphuric, hydrochloric, acetic, oxalic, or
tartaric. An alkali changes the pale red, or the deep crimson in the
case of the acidulated infusion, to bright green.

=Uses=—An infusion of red rose petals, acidulated with sulphuric acid
and slightly sweetened, is a very common and agreeable vehicle for some
other medicines. The confection made by beating up the petals with
sugar, is also in use.


PETALA ROSÆ CENTIFOLIÆ.

_Flores Rosæ pallidæ v. incarnatæ_; _Provence Rose_, _Cabbage Rose_; F.
_Pétales de Roses pâles_; G. _Centifolienrosen_.

=Botanical Origin=—_Rosa centifolia_ L.—This rose grows in a wild state
and with single flowers in the eastern part of the Caucasus.[995]
Cultivated and with flowers more or less double, it is found under an
infinity of varieties in all the temperate regions of the globe. The
particular variety which is grown in England for medicinal use, is
known in English gardens as the _Cabbage Rose_, but other varieties are
cultivated for similar purposes on the Continent.

_R. centifolia_ L. is very closely allied to _R. gallica_ L.; though
Boissier maintains the two species, there are other botanists who
regard them as but one. The rose cultivated at Puteaux near Paris
for druggists’ use, and hence called _Rose de Puteaux_, is the _Rosa
bifera_ of Redouté, placed by De Candolle though doubtfully under _R.
damascena_.

=History=—We are unable to trace the history of the particular variety
of rose under notice. That it is not of recent origin, seems evident
from its occurrence chiefly in old gardens. The _Rosa pallida_ of the
older English writers on drugs[996] was called _Damask Rose_, but that
name is now applied at Mitcham to _Rosa gallica_ L., which has very
deep-coloured flowers.

=Production=—The Cabbage Rose is cultivated in England to a very small
extent, rose water, which is made from its flowers, being procurable
of better quality and at a lower cost in other countries, especially
in the south of France. At Mitcham, whence the London druggists have
long been supplied, there are now (1873) only about 8 acres planted
with this rose, but a supply is also derived from the market gardens of
Putney, Hammersmith and Fulham.

[994] _Yearbook of Pharm._ 1877. 63; also Filhol in _Journ. de Pharm._
xxxviii. (1860) 21; Gmelin, _Chemistry_, xvi. (1864) 522.

[995] Boissier, _Flora Orientalis_, ii. (1872) 676.

[996] As Dale, _Pharmacologia_, 1693. 416.

=Description=—The Cabbage Rose is supplied to the druggists in the
fresh state, full blown, and picked off close below the calyx. A
complete description is scarcely required: we need only say that it
is a large and very double rose, of a beautiful pink colour and of
delicious odour. The calyx is covered with short setæ tipped with a
fragrant, brown, viscid secretion. The petals are thin and delicate
(not thick and leathery as in the Tea Roses), and turn brown on drying.

In making rose water, it is the custom in some laboratories to strip
the petals from the calyx and to reject the latter; in others, the
roses are distilled entire, and so far as we have observed, with
equally good result.

=Chemical Composition=—In a chemical point of view, the petals of _R.
centifolia_ agree with those of _R. gallica_, even as to the colouring
matter. Enz in 1867 obtained from the former, malic and tartaric acid,
tannin, fat, resin, and sugar.

In the distillation of large quantities of the flowers, a little
essential oil is obtained. It is a butyraceous substance, of weak
rose-like, but not very agreeable odour. It contains a large proportion
of inodorous stearoptene. For further particulars see remarks under the
head _Attar of Rose_.

=Uses=—Cabbage roses are now scarcely employed in pharmacy for any
other purpose than making rose water. A syrup used to be prepared from
them, which was esteemed a mild laxative.


OLEUM ROSÆ.

_Attar or Otto[997] of Rose_, _Rose Oil_; F. _Essence de Roses_; G.
_Rosenöl_.

=Botanical Origin=—_Rosa damascena_ Miller, var.—This is the rose
cultivated in Turkey for the production of attar of rose; it is a tall
shrub with semi-double, light-red (rarely white) flowers, of moderate
size, produced several on a branch, though not in clusters. Living
specimens sent by Baur[998] which flowered at Tübingen, were examined
by H. von Mohl and named as above.[999]

_R. damascena_ is unknown in a wild state. Koch[1000] asserts that
it was brought in remote times to Southern Italy, whence it spread
northward. In the opinion of Baker[1001] Rosa damascena is to be
referred to Rosa gallica (see p. 259 above); it must be granted that
the Rose mentioned in footnote 2, as grown with one of us, approaches
very much to Rosa gallica.

=History=—Much as roses were prized by the ancients, no preparation
such as rose water or attar of rose was obtained from them. The
liquid that bore the name of _Rose Oil_ (ῤόδινον ἔλαιον) is stated by
Dioscorides[1002] to be a fatty oil in which roses have been steeped.
In Europe a similar preparation was in use down to the last century,
_Oleum rosarum_, _rosatum_ or _rosaceum_, signifying an infusion of
roses in olive oil in the _London Pharmacopœia_ of 1721.

[997] _Attar_ or _Otto_ is from the word _itr_ signifying _perfume_ or
_odour_; the oil is called in Turkish _Itr-yàghi_ i.e. _Perfume-oil_,
and also _Ghyùl-yàghi_ i.e. _Rose oil_.

[998] A living plant followed by excellent herbarium specimens has been
kindly given to me by Dr. Baur of Blaubeuren, the father of Dr. Baur of
Constantinople—D. H.

[999] Wiggers u. Husemann, _Jahresbericht_ for 1867. 350.

[1000] _Dendrologie_, i. (1869) 250.

[1001] _Journ. of Botany_, Jan. 1875. 8.

[1002] Lib. i. c. 53.

The first allusion to the distillation of roses we have met with, is in
the writings of Joannes Actuarius,[1003] who was physician to the Greek
emperors at Constantinople towards the close of the 13th century. Rose
water was distilled at an early date in Persia; and Nisibin, a town
north-west of Mosul, was famous for it in the 14th century.[1004]

Kämpfer speaks[1005] with admiration of the roses he saw at Shiraz
(1683-4), and says that the water distilled from them is exported
to other parts of Persia, as well as to all India; and he adds as a
singular fact, that there separates from it a certain fat-like butter,
called _Ættr gyl_, of the most exquisite odour, and more valuable even
than gold. The commerce to India, though much declining, still exists;
and in the year 1872-73, 20,100 gallons of rose water, valued at 35,178
rupees (£3,517), were imported into Bombay from the Persian Gulf.[1006]
Rose oil itself is no longer exported from Persia, as it still used to
be from Shiraz in the time of Niebuhr (1778).

Rose water was much used in Europe during the middle ages, both in
cookery and at the table. In some parts of France, vassals were
compelled to furnish to their lords so many bushels of roses, which
were consumed in the distillation of rose water.[1007]

The fact that a butyraceous oil of delicious fragrance is separable
from rose water, was noticed by Geronimo Rossi[1008] of Ravenna in
1582 (or in 1574?) and by Giovanni Battista Porta[1009] of Naples in
1589; the latter in his work on distillation says—“Omnium difficillime
extractionis est rosarum oleum atque in minima quantitate sed
suavissimi odoris.”[1010] The oil was also known to the apothecaries
of Germany in the beginning of the 17th century, and is quoted in
official drug-tariffs of that time.[1011] Angelus Sala, about 1620, in
describing the distillation of the oil speaks of it as being of “ ...
candicante pinguedine instar Spermatis Ceti.” In Pomet’s time (1694) it
was sold in Paris, though, on account of its high price, only in very
small quantity. The mention of it by Homberg[1012] in 1700, and in a
memoir by Aublet[1013] (1775) respecting the distillation of roses in
the Isle of France, shows that the French perfumers of the last century
were not unacquainted with true rose oil, but that it was a rare and
very costly article.

The history of the discovery of the essence in India, is the subject
of an interesting and learned pamphlet by Langlès,[1014] published
in 1804. He tells us on the authority of oriental writers, how on
the occasion of the marriage of the Mogul emperor Jehan Ghir with
Nur-jehan, A.D. 1612, a canal in the garden of the palace was filled
with rose water, and that the princess observing a certain scum on the
surface, caused it to be collected and found it of admirable fragrance,
on which account it received the name of _Atar-jehanghiri_, i.e.
_perfume of Jehan Ghir_. In later times, Polier[1015] has shown that
rose oil is prepared in India by simple distillation of the flowers
with water. But this Indian oil has never been imported into Europe as
an article of trade.

[1003] “ ... stillatitii rosarum liquoris libra una.” _De Methodo
Medendi_, lib. v. c. 4.

[1004] _Voyage d’Ibn Batoutah_, trad. par Defrémery, ii. (1854) 140.

[1005] _Amœnitates_, 1712. 373.

[1006] _Statement of the Trade and Navigation of the Presidency of
Bombay_ for 1872-73, part ii. 52.

[1007] Le Grand d’Aussy, _Hist. de la vie privée des François_, ii.
(1815) 250.

[1008] Hieronymi Rubei Rav. _De Destillatione_, Ravennæ, 1582. 102.

[1009] _Magiæ Naturalis libri xx_, Neap. 1589. 188.

[1010] _De Distillatione_, Romæ (1608) 75.

[1011] Flückiger, _Documente zur Geschichte der Pharm._ Halle, 1876.
37. 38. 40.

[1012] _Observations sur les huiles des plantes—Mém. de l’Acad. des
Sciences_, 1700. 206.

[1013] _Hist. des Plantes de la Guiane françoise_, ii. Mémoires, p. 125.

[1014] _Recherches sur la découverie de l’Essence de Rose_, Paris, 1804.

[1015] _Asiatick Researches_, i. (1788) 332.

As already stated, the supplies at present come from European Turkey;
but at what period the cultivation of the rose and manufacture of its
oil were then introduced, is a question on which we are quite in the
dark. There is no mention of attar in the account given by Savary[1016]
in 1750 of the trade of Constantinople and Smyrna, but in the first
years of the present century some rose oil was obtained in the Island
of Chios as well as in Persia.[1017]

In English commerce, attar of rose was scarcely known until the
commencement of the present century. It was first included in the
British tariff in 1809, when the duty levied on it was 10_s._ per
ounce. In 1813 the duty was raised to 11_s._ 10½_d._; in 1819 it
was 6_s._, and in 1828, 2_s._ per ounce. In 1832 it was lowered to
1_s._ 4_d._ per lb., in 1842 to 1_s._ and in 1860 it was altogether
removed.[1018]

On searching a file of the _London Price Current_, the first mention of
“_Otto of Rose_” is in 1813, from which year it is regularly quoted.
The price (in bond) from 1813 to 1815, varied from £3 to £5 5_s._ per
ounce. The earliest notice of an importation is under date 1-8 July,
1813, when duty was paid on 232 ounces, shipped from Smyrna.

=Production=—The chief locality for attar of rose, and that by which
European commerce is almost exclusively supplied, is a small tract of
country on the southern side of the Balkan mountains, the “Tekne” of
Kazanlik or Kisanlik, an undulated plain famous for its beauty, as
picturesquely sketched by Kanitz[1019] and many other travellers. The
principal seat of the trade is the town of Kizanlik, in the valley of
the Tunja. The other important districts are those of Philippopli,
Eski Zaghra, Yeni Zaghra, Tchirpan, Giopca, Karadsuh-Dagh, Kojun-Tepe,
Pazandsik. North of the Balkans, there is only Travina to be mentioned
as likewise producing attar. All these places with Kizanlik were
estimated in 1859 to include 140 villages, having 2,500 stills.

The rose is cultivated by peasants in gardens and open fields, in
which it is planted in rows as hedges, 3 to 4 feet high. The best
localities are those occupying southern or south-eastern slopes.
Plantations in high mountainous situations generally yield less, and
the oil is of a quality that easily congeals. The flowers attain
perfection in April and May, and are gathered before sunrise; those
not wanted for immediate use are spread out in cellars, but are always
used for distilling the same day. The apparatus is a copper still of
the simplest description, connected with a straight tin tube, cooled
by being passed through a tub fed by a stream of water. The largest
establishment, “Fabrika,” at Kizanlik has 14 such stills. The charge
for a still is 25 to 50 lb. of roses, from which the calyces are not
removed. The first runnings are returned to the still; the second
portion, which is received in glass flasks, is kept at a temperature
not lower than 15° C. for a day or two, by which time most of the oil,
bright and fluid, will have risen to the surface. From this, it is
skimmed off by means of a small tin funnel having a fine orifice, and
provided with a long handle. There are usually several stills together.

[1016] _Dict. de Commerce_, iv. 548.

[1017] Oliver, _Voyage dans l’Empire Othoman_, etc. ii. (Paris, An 9)
139, v. (1807) 367.

[1018] Information obligingly communicated by Mr. Seldon of the
Statistical Office of the Custom-house.

[1019] _Donau-Bulgarien_, ii. (1877) 103-123.—A figure of a still is
given, p. 123. A good map of the Tekne of Kizanlik and environs will
be found in _Zeitschrift der Gesellschaft für Erdkunde zu Berlin_, xi.
(1876) Taf. 2.

The produce is extremely variable. According to Baur,[1020] whose
interesting account of attar of rose is that of an eye-witness, it
may be said to average 0·04 per cent. Another authority estimates the
average yield as 0·037 per cent.

The harvest during the five years 1867-71 was reckoned to average
somewhat below 400,000 _meticals_,[1021] or 4226 lb. avoirdupois; that
of 1873, which was good, was estimated at 500,000 _meticals_, value
about £70,000.[1022]

Roses are cultivated to a considerable extent about Grasse, Cannes
and Nice in the south of France; and besides much rose water, which
is largely exported to England, a little oil is produced. The latter,
which commands a high price, fuses less easily than the Turkish.

There is a large cultivation of the rose for the purpose of making
rose water and attar, at Ghazipur on the Ganges, Lahore, Amritsar
and other places in India, but the produce is wholly consumed in the
country. The species thus cultivated is stated by Brandis[1023] to be
_R. damascena_. Medinet Fayum, south-west of Cairo, supplies the great
demand of Egypt for rose vinegar and rose water.

Tunis has also some celebrity for similar products, which however do
not reach Europe. A recent traveller[1024] states that the rose grown
there, and from which attar is obtained, is _Rosa canina_ L., which
is extremely fragrant; 30 lb. of the flowers afford about 1½ drachms,
worth 15_s._ When at Genoa, in 1874, one of us (F.) had the opportunity
of ascertaining that excellent oil of rose is occasionally imported
there from Tunis.

The butyraceous oil which may be collected in distilling roses in
England for rose water is of no value as a perfume.

=Description=—Oil of rose is a light yellow liquid, of sp. gr. 0·87
to 0·89. By a reduction of temperature, it concretes owing to the
separation of light, brilliant, platy crystals of a stearoptene, the
proportion of which differs with the country in which the roses have
been grown, the state of the weather during which the flowers were
gathered, and other circumstances less well ascertained. The oil
produced in the Balkans solidifies, according to Baur, at from 11
to 16° C. In some experiments made by one of us[1025] in 1859, the
_fusing_ point of true Turkish attar was found to vary from 16 to 18°;
that of a sample from India was 20° C.; of oil distilled in the south
of France, 21 to 23°, of an oil produced in Paris, 29°; of oil obtained
in distilling roses for rose water in London, 30 to 32° C.

[1020] _Pharm. Journ._ ix. (1868) 286.

[1021] _Consular Reports presented to Parliament, May_, 1872.—The
_metical_, _miskal_ or _midkal_ is equal to about 3 dwt. troy=4794
grammes.

[1022] _Consular Reports presented to Parliament_, Aug. 1873. 1090.

[1023] _Forest Flora of North-western and Central India_, 1874. 200.—D.
Forbes Watson, Catal. of the Indian Department, Vienna exhibition,
1873. 98.

[1024] Von Maltzan, _Reise in den Regentschaften Tunis und Tripolis_,
Leipzig, 1870.

[1025] Hanbury, _Pharm. Journ._ xviii. (1859). 504-509. _Science
Papers_, 172.

From these data, it appears that a cool northern climate is not
conducive to the production of a highly odorous oil; and even in
Bulgaria experience shows that the oil of the mountain districts holds
a larger proportion of stearoptene than that of the lowlands.

Turkish oil of rose is stated by Baur to deviate a ray of polarized
light 4° to the right, when examined in a column of 100 mm. The oil
from English roses which we examined exhibited no rotation.

=Chemical Composition=—Rose oil is a mixture of a liquid constituent
containing oxygen, to which it owes its perfume, and the solid
hydrocarbon or stearoptene already mentioned, which is entirely
destitute of odour. The proportion which these bodies bear to each
other is extremely variable. From the Turkish oil, it may be obtained
to the extent of 18 per cent., and from French and English to 35, 42,
60 or even 68 per cent.

Though the stearoptene can be entirely freed from the oxygenated
oil, no method is known for the complete isolation of the latter. As
obtained by Gladstone[1026], it had a sp. gr. of 0·881 and a boiling
point of 216° C.

With regard to the stearoptene of rose oil, the analyses of Théodore de
Saussure (1820) and Blanchet (1833) long since showed its composition
to accord with the formula CₙH₂ₙ. The experiments of one of us[1027]
confirm this striking fact, which assigns to the stearoptene in
question a very exceptional place among the hydrocarbons of volatile
oils, all of which are less rich in hydrogen.

Rose stearoptene separates when attar of roses is mixed with alcohol.
We have isolated it also from oil obtained from Mitcham roses, by
diluting the oil with a little chloroform and precipitating with
glacial acetic acid or spirit of wine, the process being several times
repeated. The stearoptene was lastly maintained for some days at
100° C.; thus obtained, it is inodorous, but when heated evolves an
offensive smell like that of heated wax or fat. At 32·5° it melts; at
150° vapour is evolved; at 272° C. it begins to boil, soon after which
it turns brown and then blackish. Stains of the stearoptene on paper
do not disappear by the heat of the water-bath and the relapse of some
days.

If cautiously melted by the warmth of the sun, the stearoptene forms
on cooling microscopic crystals of very peculiar shape. Most of them
have the form of truncated hexahedral pyramids, not however belonging
to the rhombohedric system, as the angles are evidently not equal;
many of them are oddly curved, thus §. Examined under the polarizing
microscope, these crystals from their refractive power make a brilliant
object.

Rose stearoptene is a very stable body, yet by boiling it for some days
with fuming nitric acid, it is slowly dissolved, and converted into
various acids of the homologous series of fatty acids, and into oxalic
acid. Among the former, we detected butyric and valerianic. The chief
product is however succinic acid, which we obtained in pure crystals,
showing all the well-known reactions.

[1026] _Journ. of Chem. Soc._ x. (1872) 12.

[1027] Flückiger, _Pharm. Journ._ x. (1869) 147.

The same products are obtained even much easier by treating paraffin
with nitric acid; it yields however less of succinic acid. The general
behaviour and appearance of paraffin is in fact nearly the same as
that of rose stearoptene. But what is called _paraffin_, is a series
of extremely similar hydrocarbons, answering to the general formula
CₙH₍₂ₙ₊₂₎ (_n_ being equal to more than 16), the separation of which
has not yet been thoroughly effected. The fusion point of the different
kinds of paraffin generally ranges from 42 to 60° C., yet one sort from
the bituminous shale of Autun, prepared and examined by Laurent,[1028]
melts at 33° C., and in this respect agrees with our stearoptene. It
is therefore possible that the latter actually belongs to the paraffin
series.

We have not ascertained the correctness of Baur’s strange experiments
(1872, _Jahresbericht der Pharm._ p. 460), by which he believes to have
converted the liquid part of rose oil into the stearoptene by means of
a current of hydrogen.

=Commerce=—Formerly attar of rose came into commerce by way of
Austria; it is now shipped from Constantinople. From the interior,
it is transported in flattened round tin bottles called _kunkumas_,
holding from 1 to 10 lb., which are sewed up in white woollen cloth.
These sometimes reach this country, but more commonly the attar is
transferred at Constantinople to small white glass bottles, ornamented
with gilding, imported from Germany.

=Uses=—Attar of rose is of no medicinal importance, but serves
occasionally as a scent for ointments. Rose water is sometimes made
with it, but is not so good as that distilled from the flowers. Attar
is much used in perfumery, but still more in the scenting of snuff.

=Adulteration=—No drug is more subject than attar of rose to
adulteration, which is principally effected by the addition of the
volatile oil of an Indian grass, _Andropogon Schœnanthus_ L. This
oil, which is called in Turkish _Idris yàghi_, and also _Entershah_,
and is more or less known to Europeans as _Geranium Oil_, is imported
into Turkey for this express purpose, and even submitted to a sort
of purification before being used.[1029] It was formerly added to
the attar only in Constantinople, but now the mixing takes place
at the seat of the manufacture. It is said that in many places the
roses are absolutely sprinkled with it before being placed in the
still. As grass oil does not solidify by cold, its admixture with
rose oil renders the latter less disposed to crystallize. Hence
arises a preference among the dealers in Turkey for attar of the
mountain districts, which, having a good proportion of stearoptene,
will bear the larger dilution with grass oil without its tendency to
crystallize becoming suspiciously small. Thus, in the circular of a
commercial house in Constantinople, dated from Kizanlik, occur the
phrases—“_Extra strong oil_,”—“_Good strong congealing oil_,”—“_Strong
good freezing oil_;”—while the 3rd quality of attar is spoken of as
a “_not congealing oil_.” The same circular states the belief of the
writers, that in the season in which they wrote, “_not a single metical
of unadulterated oil_” would be sent away.

The chief criteria, according to Baur, for the purity of rose oil
are:—1. _Temperature at which crystallization takes place_: a good
oil should congeal well in five minutes at a temperature of 12·5° C.
2. _Manner of crystallizing._—The crystals should be light, feathery,
shining plates, filling the whole liquid. Spermaceti, which has been
sometimes used to replace the stearoptene, is liable to settle down in
a _solid cake_, and is easily recognizable. Furthermore, it melts at
50° C. and so do most varieties of paraffin. The microscopic crystals
of the latter are somewhat similar to those of rose stearoptene, yet
they may be distinguished by an attentive comparative examination.

[1028] _Ann. de Chim. et de Phys._ liv. (1833) 394.

[1029] For particulars, see Baur (p. 262, note 3).


FRUCTUS ROSÆ CANINÆ.

_Cynosbata_; _Fruit of the Dog-rose_, _Hips_; F. _Fruits de
Cynorrhodon_; G. _Hagebutten_.

=Botanical Origin=—_Rosa canina_ L., a bush often 10 to 12 feet high,
found in hedges and thickets throughout Europe except Lapland and
Finland, and reaching the Canary Islands, Northern Africa, Persia and
Siberia; universally dispersed throughout the British Islands.[1030]

=History=—The fruits of the wild rose, including other species besides
_R. canina_ L., have a scanty, orange, acid, edible pulp, on account
of which they were collected in ancient times when garden fruits were
few and scarce. Galen[1031] mentions them as gathered by country people
in his day, as they still are in Europe. Gerarde in the 16th century
remarks that the fruit when ripe—“maketh most pleasant meats and
banqueting dishes, as tarts and such like.“ Though the pulp of hips
preserved with sugar which is here alluded to, is no longer brought to
table, at least in this country,[1032] it retains a place in pharmacy
as a useful ingredient of pill-masses and electuaries.

=Description=—The fruit of a rose consists of the bottle-shaped calyx,
become dilated and succulent by growth, and sometimes crowned with 5
leafy segments, enclosing numerous dry carpels or achenes, containing
each one exalbuminous seed. The fruit of _R. canina_ called a _hip_, is
ovoid, about ¾ of an inch long, with a smooth, red, shining surface. It
is of a dense, fleshy texture, becoming on maturity, especially after
frost, soft and pulpy, the pulp within the shining skin being of an
orange colour, and of an agreeable sweetish subacid taste. The large
interior cavity contains numerous hard achenes, which, as well as the
walls of the former, are covered with strong short hairs.

For medicinal use, the only part required is the soft orange pulp,
which is separated by rubbing it through a hair sieve.

=Microscopic Structure=—The epidermis of the fruit is made up of
tabular cells containing red granules, which are much more abundant
in the pulp. The latter, as usual in many ripe fruits, consists of
isolated cells no longer forming a coherent tissue. Besides these
cells, there occur small fibro-vascular bundles. Some of the cells
enclose tufted crystals of oxalate of calcium; most of them however
are loaded with red granules, either globular or somewhat elongated.
They assume a bluish hue on addition of perchloride of iron, and are
turned blackish by iodine. The later colouration reminds one of that
assumed by starch granules under similar circumstances; yet on addition
of a very dilute solution of iodine, the granules always exhibit a
_blackish_, not a blue tint, so that they are not to be considered
as starch granules. The hairs of the pulp are formed of a single,
thick-walled cell, straight or sometimes a little crooked.

[1030] Baker, _Journ. of Linn. Soc._ Bot. xi. (1869) 226.

[1031] _De Alimentorum facultatibus_, ii. c. 14. In the Amur country a
much larger and better fruit is afforded by _R. acicularis_ Lindl. and
_R. cinnamomea_ L.—Maximowicz, _Primitiæ Floræ Amurensis_, 1859. 100.
453.

[1032] In Switzerland and Alsace a very agreeable _confiture_ of hips
is still in use.

=Chemical Composition=—The pulp examined by Biltz (1824) was found to
afford nearly 3 per cent. of citric acid, 7·7 of malic acid, besides
citrates, malates and mineral salts, 25 per cent. of gum, and 30 of
uncrystallizable sugar.

=Uses=—Hips are employed solely on account of their pulp, which mixed
with twice its weight of sugar, constitutes the _Confectio Rosæ caninæ_
of pharmacy.


SEMEN CYDONIÆ.

_Quince Seeds_, _Quince Pips_; F. _Semences ou Pepins de Coings_; G.
_Quittensamen_.

=Botanical Origin=—_Pirus Cydonia_ L. (_Cydonia vulgaris_ Pers.), the
quince tree, is supposed to be a true native of Western Asia, from
the Caucasian provinces of Russia to the Hindu Kush range in Northern
India. But it is now apparently wild also in many of the countries
which surround the Mediterranean basin.

In a cultivated state, it flourishes throughout temperate Europe,
but is far more productive in southern than in northern regions.
Quinces ripen in the south of England, but not in Scotland, nor in St.
Petersburg, or in Christiana.

=History=—The quince was held in high esteem by the ancients, who
considered it an emblem of happiness and fertility; and, as such, it
was dedicated to Venus, whose temples it was used to decorate. Some
antiquarians maintain that quinces were the _Golden Apples_ of the
Hesperides. The name Cydonia alludes to the town of Kydon, now Canea,
in Creta; in the Talmud quinces are called Cretan apples.

Porcius Cato in his graphic description of the management of a Roman
farmhouse, alludes to the storing of quinces both cultivated and wild;
and there is much other evidence to prove that from an early period the
quince was abundantly grown throughout Italy. Charlemagne, A.D. 812,
enjoined its cultivation in central Europe.[1033] At what period it
was introduced into Britain is not evident, but we have observed that
_Baked Quinces_ are mentioned among the viands served at the famous
installation feast of Nevill, archbishop of York in 1466.[1034]

The use of mucilage of quince seeds has come to us through the
Arabians; it is still met with in Turkestan.

=Description=—The quince is a handsome fruit of a golden yellow, in
shape and size resembling a pear. It has a very agreeable and powerful
smell, but an austere, astringent taste, so that it is not eatable in
the raw state. In structure, it differs from an apple or a pear in
having many seeds in each cell, instead of only two.

[1033] Pertz, _Monumenta Germaniæ historica_, Legum, i. (1835) 187.

[1034] Leland, _De rebus Britannicis Collectanea_, vi. (1774) 5.

The fruit is, like an apple, 5-celled, with each cell containing a
double row of closely-packed seeds, 8 to 14 in number, cohering by a
soft mucilaginous membrane with which each is surrounded. By drying,
they become hard, but remain agglutinated as in the cell. The seeds
have an ovoid or obconic form, rather flattened and 3-sided by mutual
pressure. From the hilum at the lower pointed end, the raphe passes as
a straight ridge to the opposite extremity, which is slightly beaked
and marked with a scar indicating the chalaza. The edge opposite
the raphe is more or less arched according to the position of the
individual seed in the cell. The testa encloses two thick, veined
cotyledons, having a straight radicle directed towards the hilum.

Quince seeds have a mahogany-brown colour, and when unbroken a simply
mucilaginous taste. But the kernels have the odour and taste of bitter
almonds, and evolve hydrocyanic acid when comminuted and mixed with
water.

=Microscopic Structure=—The epidermis of the seed consists of one row
of cylindrical cells, the walls of which swell up in the presence of
water and are dissolved, so as to yield an abundance of mucilage.
This process can easily be observed, if thin sections of the seed are
examined under glycerine, which acts on them but slowly.

=Chemical Composition=—The mucilage of the epidermis is present in such
quantity, that the seed easily coagulates forty times its weight of
water. By complete exhaustion, the seeds afford about 20 per cent. of
dry mucilage, containing considerable quantities of calcium salts and
albuminous matter, of which it is not easily deprived. When treated
with nitric acid, it yields oxalic acid. After a short treatment with
strong sulphuric acid it is coloured blue by iodine. Tollens and
Kirchner (1874) assign to it the formula C₁₈H₂₈O₁₄, regarding it as a
compound of gum, C₁₂H₂₀O₁₀, and cellulose, C₆H₁₀O₅, less one molecule
of water.

Quince mucilage has but little adhesive power, and is not thickened by
borax. That portion of it which is really in a state of solution and
which may be separated by filtration, is precipitable by metallic salts
or by alcohol. The latter precipitate after it has been dried is no
longer dissolved by water either cold or warm. Quince mucilage is, on
the whole, to be regarded as a soluble modification of cellulose.

The seeds on distillation with water afford a little hydrocyanic acid,
and, probably, bitter almond oil.

=Commerce=—Quince seeds reach England from Hamburg; and are frequently
quoted in Hamburg price-currents as _Russian_; they are also brought
from the south of France and from the Cape of Good Hope. They are
largely imported into India from the Persian Gulf, and by land from
Afghanistan.

=Uses=—A decoction of quince seeds is occasionally used as a demulcent
external application in skin complaints. It is also sometimes added to
eye-lotions. Quince seeds are in general use among the natives of India
as a demulcent tonic and restorative. They have been found useful by
Europeans in dysentery.




HAMAMELIDEÆ.


STYRAX LIQUIDUS.[1035]

_Balsamum Styracis_; _Liquid Storax_; F. _Styrax liquide_; G.
_Flüssiger Storax_.

=Botanical Origin=—_Liquidambar orientalis_ Miller (_L. imberbe
Aiton_), a handsome, umbrageous tree resembling a plane, growing to
the height of 30 to 40 feet or more,[1036] and forming forests in the
extreme south-western part of Asia Minor. In this region the tree
occurs in the district of Sighala near Melasso, about Budrum (the
ancient Halicarnassus) and Moughla, also near Giova and Ullà in the
Gulf of Giova, and lastly near Marmorizza and Isgengak opposite Rhodes.
It also grows in the valley of the El-Asi (the ancient Orontes), as
proved by a specimen in the Vienna herbarium, collected by Gödel,
Austrian Consul at Alexandretta. In this locality it was seen by
Kotschy in 1835, but mistaken for a plane. The same traveller informed
one of us that he believed it to occur at Narkislik, a village near
Alexandretta.

The tree is not known to grow in Cyprus, Candia, Rhodes, Kos, or indeed
in any of the islands of the Mediterranean.[1037]

=History=—Two substances of different origin have been known from a
remote period under the name of _Styrax_ or _Storax_, namely the resin
of _Styrax officinalis_ L. (see further on), and that of _Liquidambar
orientalis_ Miller, the latter commonly distinguished as _Liquid
Storax_.

According to Krinos of Athens, who has carefully investigated the
history of the drug,[1038] the earliest allusions to Liquid Storax
occur in the writings of Aëtius and of Paulus Ægineta,[1039] who
name both _Storax_ and _Liquid Storax_ (πύρα ζυγρὸς). Of these Greek
physicians, who lived respectively in the 6th and 7th centuries, the
second also mentions the resin of Ζυγία, which is regarded by Krinos as
synonymous with the latter substance.[1040]

[1035] The feminine gender of Styrax has been in use for a long time.
In Greek it denotes the tree, as also does sometimes the masculine
gender, the _neutral_ being reserved to the resin. In Latin the resin
is masculini generis (Dr. Rice).

[1036] For a good figure of _L. orientalis_, see Hooker’s _Icones
Plantarum_ (3rd series, 1867) pl. 1019, or Hanbury, _Science Papers_,
1876. 140; also Bentley and Trimen, _Medicinal Plants_, part 27 (1877).

[1037] The fine old trees existing at the convent of Antiphoniti on the
north coast of Cyprus, and at that of Neophiti near Papho, specimens
of which were distributed by Kotschy as _Liquidambar imberbis_ Ait.,
agree in all points with the American _L. stryaciflua_ L., and not with
the Asiatic plant. Kotschy has told me that they have _certainly been
planted_, and that no other examples exist in the island.—D. H. The
same opinion is adopted by Boissier, _Flora Orientalis_, ii. (1872)
8319.

[1038] Περί Στύακοτ δίατριβὴ ϕαρμακογραϕικὴ ἐν Ἀθῆναιπ, 1862.—This
pamphlet is also the subject of a paper of Prof. Planchon, _Journ. de
Pharm._ 24 (1876) 172. 243.

[1039] _Medicæ Artis Principes post Hippocratem et Galenum_, Par.
1567.—Aëtii tetr. 4. serm. 4. c. 122; P. Ægineta, _De re med._ vii. 20.

[1040] The foliage of the Liquidambar much resembles that of the common
maple (_Acer campestre_ L.); hence the two trees as well as the plane
(_Platanus orientalis_ L.) are confounded under one name,—Ζυγὸς or
Ζυγίᾳ. So _Styrax officinalis_ L., from the resemblance of its leaves
to those of _Pirus Cydonia_ L., is known in Greece as Ζυγὸς κυδωνήα
kydônêa, i.e. _wild quince_.

We find in fact the term _Sigia_ frequently mentioned by Rhazes (10th
century) as signifying Liquid Storax. This and other Arabian physicians
were also familiar with the same substance under the name of _Miha_
(_may’a_), and also knew how and whence it was obtained.[1041]

A curious account of the collecting of Liquid Storax from the tree
_Zygia_, and from another tree called _Stourika_, is given in the
travels through Asia Minor to Palestine of the Russian abbot of Tver in
A.D. 1113-1115.[1042]

The wide exportation and ancient use of Liquid Storax are very
remarkable: even in the first century, as appears by the author of the
Periplus of the Erythrean Sea, Storax, by which term there can be but
little doubt _Liquid Storax_ was intended, was exported by the Red
Sea to India. Whether the _Storax_ and _Storax Isaurica_ offered to
the Church of Rome under St. Silvester, A.D. 314-335, by the emperor
Constantine,[1043] was Liquid Storax or the more precious resin of
_Styrax officinalis_ L., is a point we cannot determine. That the
Chinese used the drug was a fact known to Garcia de Orta (1535-63):
Bretschneider[1044] has shown from Chinese sources that, together with
olibanum and myrrh, it was imported by the Arabs into China during
the Ming dynasty, A.D. 1368-1628. This trade is still carried on: the
drug is conveyed by way of the Red Sea to Bombay, and thence shipped
to China. Official returns show that the quantity thus exported from
Bombay in the year 1856-57 was 13,328 lb. In the time of Kämpfer
(1690-92), Liquid Storax was one of the most profitable articles of
shipment to Japan.[1045]

Liquid Storax is known in the East, at least in the price-currents and
trade statistics of Europeans, by the strange-sounding name of _Rose
Malloes_ (_Rosa Mallas_, _Rosum Alloes_, _Rosmal_), a designation for
it in use in the time of Garcia de Orta. Clusius[1046] considered it to
be Arabic, which, however, the scholars whom we have consulted do not
allow. Others identify it with _Rasamala_, the Malay name for _Altingia
excelsa_. (See further on.)

The botanical origin of Liquid Storax was long a perplexing question
to pharmacologists. It was correctly determined by Krinos, but his
information on the subject published in a Greek newspaper in 1841, and
repeated by Kosté in 1855,[1047] attracted no attention in Western
Europe. The question was also investigated by one of the authors
of the present work, whose observations, together with a figure of
_Liquidambar orientalis_ Miller, were published in 1857.[1048]

[1041] _Ibn Baytar_, Sontheimer’s transl. ii. 539.

[1042] Noroff, _Pèlerinage en Terre Sainte de l’Igoumène russe Daniel_,
St. Pétersb. 164.4°.—The passage has been kindly abstracted for us by
Prof. Heyd of Stuttgart.

[1043] Vignolius, _Liber Pontificalis_, Romæ, i. (1724) 94.—The ancient
Isauria was in Cilicia, the country of _Styrax officinalis_ L.

[1044] _On the knowledge possessed by the Chinese of the Arabs_, etc.,
Lond. 1871. 19.

[1045] _Hist. of Japan_, ed. Scheuchzer, i. 353.

[1046] _Exoticorum Libri_, 245.

[1047] Ἐγχειρίδιον Φαρμακολογίας, ύπὸ Ν. Κωστῆ, 1855. 356.

[1048] Hanbury, _Pharm. Journ._ xvi. (1857) 417. 461, and iv. (1863)
436; _Science Papers_, 127-150.

=Method of Extraction=—The extraction of Liquid Storax is carried on
in the forests of the south-west of Asia Minor, chiefly by a tribe of
wandering Turcomans called _Yuruks_. The process has been described
on the authority of Maltass and McCraith of Smyrna, and of Campbell,
British Consul at Rhodes.[1049] The outer bark is said to be first
removed from the trunk of the tree and rejected; the inner is then
scraped off with a peculiar iron knife or scraper, and thrown into pits
until a sufficient quantity has been collected. It is then boiled with
water in a large copper, by which process the resin is separated, so
that it can be skimmed off. This seems to be performed with sea water;
some chloride of sodium can therefore be extracted from the drug. The
boiled bark is put into hair bags and squeezed under a rude lever, hot
water being added to assist in the separation of the resin, or as it
is termed _yagh_, i.e. _oil_. Maltass states that the bark is pressed
in the first instance _per se_, and afterwards treated with hot water.
In either case the products obtained are the opaque, grey, semi-fluid
resin known as _Liquid Storax_, and the fragrant cakes of foliaceous,
brown bark, once common[1050] but now rare in European pharmacy, called
_Cortex Thymiamatis_.

We are indebted to M. Felix Sahut of Montpellier for a specimen of
the bark of _Liquidambar orientalis_, cut from the trunk of a fine
tree on his property at the neighbouring village of Lattes. The bark
which is covered with a very thick corky layer and soaked in its own
fragrant resin, shows no tendency to exfoliate. The investigations
of Unger[1051] in Cyprus are consequently to us inexplicable; he
asserts that the bark scales off, like that of the plane, by continued
exfoliation, which is not the case with that of M. Sahut’s tree.

[1049] Hanbury, _l.c._

[1050] It is no doubt the “_Cortex Olibani_” met with in the tariff of
1571, in Flückiger, _Documente zur Geschichte der Pharmacie_, 26.

[1051] Unger u. Kotschy, _Die Insel Cypern_. Wien, 1865. 410.

=Description=—Liquid Storax is a soft viscid resin, usually of the
consistence of honey, heavier than water, opaque and greyish brown. It
always contains water, which by long standing rises to the surface.
In one sample that had been kept more than 20 years, the resin at the
bottom of the bottle formed a transparent layer of a pale golden brown.
When liquid storax is heated, it becomes by the loss of water dark
brown and transparent, the solid impurities settling to the bottom.
Spread out in a very thin layer, it partially dries, but does not
wholly lose its stickiness. When free from water (which reddens litmus)
it dissolves in alcohol, spirit of wine, chloroform, ether, glacial
acetic acid, bisulphide of carbon, and most of the essential oils, but
not in the most volatile part of petroleum (“petroleum ether”). It has
a pleasant balsamic smell, especially after it has been long kept; when
recent, it is contaminated with an odour of bitumen or naphthalene
that is far from agreeable. Its taste is sharply pungent, burning and
aromatic.

When the opaque resin is subjected to microscopic examination, small
brownish granules are observed in a viscid, colourless, transparent
liquid, besides which large drops of a mobile watery liquid may
be distinguished. In polarized light, numerous minute crystalline
fragments with a few larger tabular crystals are obvious. But when
thin layers of the resin are left on the object glass in a warm
place, feathery or spicular crystals (styracin) shoot out on the
edge of the clear liquid, while in the large, sharply-defined drops
above mentioned, rectangular tables and short prisms (cinnamic acid)
make their appearance. On applying more warmth after the water is
evaporated, all the substances unite into a transparent, dark brown,
thick liquid, which exhibits no crystalline structure on cooling, or
only after a very long time. Among the fragments of the bark occurring
in the crude resin, liber-fibres are frequently observable.

=Chemical Composition=—The most abundant constituent of Styrax is
probably the _Storesin_, C₃₆H₅₅(OH)₃, discovered in 1877 by W. von
Miller, or rather cinnamic ethers of it and of an isomeric substance.
Storesin is an amorphous substance melting at 168° C., readily soluble
in petroleum ether. Several other compound ethers have also been
observed in the drug, as for instance _cinnamic ether of phenylpropyl_,
_cinnamic ether of ethyl_, cinnamic ether of benzyl, and especially
cinnamate of cinnamyl, C₉H₇O₂·C₉H₉, the so-called _Styracin_. This
substance, discovered by Bonastre in 1827, can be removed by ether,
benzol or alcohol, after the separation from the resin of the cinnamic
acid; it is insoluble in water, and volatile only in super-heated
steam. It crystallizes in tufts of long rectangular prisms, which
melt at 38° C., but it frequently does not solidify in a crystalline
form, or only after a long time, or remains as an oily liquid. In its
pure state it is inodorous and tasteless. By concentrated solution
of potash, it is resolved into a cinnamate, and cinnamic alcohol
(_Styrone_) C₉H₁₀O, which latter is not present in Liquid Storax. The
_cinnamic acid_ may be extracted to a small extent by boiling water,
more completely by means of a boiling solution of carbonate of sodium,
as it is present in the drug partly in the free state. Its compound
ethers may be decomposed by caustic lye. The yield of cinnamic acid
accordingly varies from 6 to 12 per cent.—or even, according to Löwe,
as much as 23 per cent. of crystallized cinnamic acid can be obtained.
The acid dissolves abundantly in ether, alcohol, or hot water, slightly
in cold water; it is inodorous, but has an acrid taste. It fuses at
133° C., and boils at 290° C.; at a dull red heat it is resolved into
carbonic acid and styrol, which latter is therefore related to it in
the same manner as benzol (benzene) to benzoic acid. Liquid styrax is
in fact the best source of cinnamic acid.

Another constituent of styrax is a fragrant substance, perhaps
_ethylvanillin_, occurring in but small quantity.

Laubenheimer (1872) has shown that probably _Benzylic Alcohol_, C₇H₈O,
boiling at 206° C., likewise occurs in Liquid Storax; it has not been
found by Miller. The latter chemist also showed that water removes from
the drug a little _benzoïc acid_; he observed moreover a substance
similar to _caoutchouc_ among the constituents of liquid styrax.

There is further to be mentioned as having been met with in Liquid
Storax a hydrocarbon, C₈H₈, first prepared by Simon in 1839, which
exists in the resin as a liquid, and also in a polymeric form as a
solid. The former called _Styrol_, _Cinnamene_, or _Cinnamol_, has a
sp. gr. of 0·924, and a boiling point of 146° C. It is a colourless,
mobile liquid which may be obtained by distilling with water liquid
storax, the odour and burning taste of which it possesses. When heated
for a considerable time to 100°, or for a shorter period to 200° C.,
it is converted without change of composition into the colourless,
transparent solid _Metastyrol_, which, unlike styrol, is not soluble
in alcohol or ether. It has a sp. gr. of 1·054, and may be cut with
a knife. By prolonged heating, it can be converted into its original
liquid form.

Styrol is to be regarded as phenylated ethylene; it can be
artificially obtained by shaking powdered cinnamic acid with saturated
hydrobromic acid, when crystalline hydrobromated cinnamic acid,
C₆H₅·CH₂·CHBr·COOH, is formed. One part of the latter, 10 parts of
water, and a little more carbonate of sodium than the quantity required
for saturation are mixed. The bromhydrocinnamate of sodium partly
splits up immediately, even at 0°, according to the following equation

    C₆H₅·CH₂·CHBr·COONa = CO₂ + NaBr + C₆H₅·CH·CH₂.
    Bromhydrocinnamate                 Styrol.
       of sodium.

24 parts of bromhydrocinnamic acid, recrystallized from boiling
bisulphide of carbon, yield about 7 parts of styrol; no other method
affords as much as this.

Styrol has been discovered in Styrax, but is not regularly, and at all
events to a minute amount only, found in the drug of the present day.
We have no explanation for the strange fact that it was apparently more
abundantly met with in former times.

Lastly there has been found in Liquid Storax, by J. H. van t’Hoff
(1876), about 0·4 per cent. of an _essential oil_, probably C₁₀H₁₆O;
Miller also pointed out a compound ether of probably the same
(alcoholic) substance as occurring in styrax.

By the action of oxidizing agents, as nitric or chromic acids, or
peroxide of lead, the cinnamyl compounds are easily reduced, carbonic
acid and water being evolved; and at the same time benzoic acid, bitter
almond oil, and hydrocyanic acid are produced. These compounds are in
fact abundantly evolved when 6 parts of Liquid Storax are gently warmed
with 1 p. of caustic soda, and then mixed with 3 p. of permanganate of
potassium dissolved in 20 p. of water.

We have examined several samples of Liquid Storax of average quality,
and found by exposure of small quantities to the heat of the steam
bath, that it lost from 10 to 20 per cent. of water. The remainder
treated with alcohol yielded a residue amounting to 13 to 18 per cent.,
consisting chiefly of fragments of bark and inorganic impurities.
The percentage of the drug soluble in alcohol, to which is due its
therapeutic value, thus amounts to 56 to 72. This part, as may be
inferred from the foregoing statements, consists chiefly of storesin,
the various compound ethers above mentioned, of cinnamic acid and of
styracin, no doubt in greatly varying proportions.

=Commerce=—The annual production of Liquid Storax was estimated by
Campbell in 1855 as about 490 cwt. for the districts of Giova and Ullá,
and 300 cwt. for those of Marmorizza and Isgengak. The drug is exported
in barrels to Constantinople, Smyrna, Syra and Alexandria. Some is also
packed with a certain proportion of water in goatskins, and sent either
by boats or overland to Smyrna, where it is transferred to barrels and
shipped mostly to Trieste.

The chief consumption of Liquid Storax would appear to be in India and
China. In the fiscal year 1866-67, Bombay imported 319 cwt. from the
Red Sea. Liquid Storax is seldom seen in the London drug-sales.

=Uses=—Liquid Storax, which the _British Pharmacopœia_ directs to be
purified by solution in spirit of wine, is an ingredient in a few
old-fashioned preparations but is hardly ever prescribed on its own
account. It is stated to be expectorant and stimulant, and useful in
chronic bronchial affections. It has been recommended by Pastau, Berlin
(1865), as an external application for the cure of scabies, for which
purpose it is mixed with linseed oil and now largely used.

=Adulteration=—The drug is occasionally mixed with sand, ashes, and
other substances; these would be detected by solution in spirit of
wine, as well as by the microscope.

Allied Substances.

_Styrax Calamita_ (_Storax en pain_ Guibourt)—The substance that now
bears this name is by no means the _Styrax Calamita_ of ancient times,
but is an artificial compound made by mixing the residual Liquidambar
bark called _Cortex Thymiamatis_ (p. 273), coarsely powdered, with
Liquid Storax in the proportions of 3 to 2. It is at first a clammy
mass, acquiring after a few weeks an appearance of mouldiness, due to
minute silky crystals of styracin. It is usually imported in wooden
drums, and has a very sweet smell. When the bark is scarce, common
sawdust is substituted for it, while qualities still inferior are made
up with the help of olibanum, honey, and earthy substances. This drug
is manufactured at Trieste, Venice and Marseilles.

Several other odoriferous compounds, of which Liquid Storax appears to
be the chief ingredient, are made in the East and may still be found in
old drug warehouses.[1052]

_Resin of Styrax officinalis_ L.; =_True Storax_=—This was a solid
resin somewhat resembling benzoin, of fragrant, balsamic odour,
held in great estimation from the time of Dioscorides and Pliny
down to the close of the last century. It was perhaps the “storace
odorifero” exported in the 12th century from Pantellaria[1053] and
Sicily. The drug was obtained from the stem of _Styrax officinalis_ L.
(_Styraceæ_), a native of Greece, Asia Minor and Syria, now found also
in Italy and Southern France. This plant when permitted to grow freely
for several years, forms a small tree, in which state alone it appears
to be capable of affording a fragrant resin. But in most localities it
has been reduced by ruthless lopping to a mere bush, the young stems
of which yield not a trace of exudation. True storax has thus utterly
disappeared.

Professor Krinos of Athens has informed us (1871) that about Adalia
on the southern coast of Asia Minor, a sort of solid storax obtained
from _S. officinalis_ is still used as incense in the churches and
mosques. The specimen of it which he has been good enough to send us,
is not however resin, but _sawdust_; it is of a pale cinnamon-brown,
and pleasant balsamic odour. By keeping, it emits an abundance of
minute acicular crystals (styracin?). The substance is interesting
in connection with the statement of Dioscorides, that the resin of
_Styrax_ is adulterated with the _sawdust of the tree itself_, and the
fact that the region where this sawdust is still in use is one of the
localities for the drug (Pisidia) which he mentions.

[1052] The _Storax noir_ of Guibourt is one of these.

[1053] Quoted before, p. 163, note 3; in the same book “_cotone storace
e corallo_“ occur as articles of export from Sicily.

_Resin of Liquidambar styraciflua_ L.—a large and beautiful tree,
native of North America from Connecticut and Illinois southward to
Mexico and Guatemala. In the United States, where it is called _Sweet
Gum_, the tree yields from natural fissures or by incision, small
quantities of a balsamic resin, which is occasionally used for chewing.
We have before us an excellent sample of it collected for Messrs.
Wallace Brothers of Statesville, N. Carolina.[1054]

In Central America this exudation is far more freely produced;
an authentic specimen from Guatemala in our possession is a pale
yellow, opaque resin of honey-like consistence, becoming transparent,
amber-coloured and brittle by exposure to the air. It has a rather
terebinthinous, balsamic odour. In the mouth it softens like benzoin
or mastich, and has but little taste. Another specimen also from
Guatemala, a thick, fluid oleo-resin, of a golden brown hue, was
contributed to the Paris Exhibition in 1878.

The resin of _L. styraciflua_ L. has been ascertained by Procter[1055]
to contain cinnamic, but not benzoic acid. Harrison[1056] found it to
contain styracin and essential oil (styrol?).

_Resin of Liquidambar formosana_ Hance—This tree, which we suppose
may be the _Styrax liquida folio minore_, which Ray names[1057] as
occurring in a collection of plants from Amoy, is a native of Formosa
and Southern China, where it affords a dry terebinthinous resin,
of agreeable fragrance when heated. Of this resin, which is used
by the Chinese, a specimen collected in Formosa by Mr. Swinhoe has
been presented to us by Dr. Hooker. A tree figured under the name of
_Fung-heang_ in the _Pun-tsao_[1058] is, we presume, this species.

_Resin of Altingia excelsa_ Noronha (_Liquidambar Altingiana_ Bl.)
=_Rasamala_= of the Javanese and Malays—The _Rasamala_ is a magnificent
tree of the Indian Archipelago, Burma and Assam. In Java it yields by
incisions in the trunk an odorous resin, yet only very slowly and in
very small quantity; this resin is not, or at least not regularly,
collected. In Burma, on the other hand, the tree affords a fragrant
balsam, of which according to Waring[1059] there are two varieties,
the one pellucid and of a light yellowish colour, obtained by simple
incision; the other thick, dark, opaque, and of terebinthinous odour,
procured by boring the stem and applying fire around the trunk.




MYRTACEÆ.


OLEUM CAJUPUTI.

_Oil of Cajuput_, _Kayu-puti Oil_; F. _Essence de Cajuput_; G.
_Cajeputöl_.

=Botanical Origin=—_Melaleuca Leucadendron_ L., a tree often attaining
a considerable size, with a thick spongy bark peeling off in layers,
and slender, often pendulous branches. It is widely spread, and
abundant in the Indian Archipelago and Malayan peninsula, and is also
found in Northern Australia, Queensland, and New South Wales.

[1054] Obligingly presented to me by our friend, Dr. Squibb, Brooklyn
(1879).—F. A. F.

[1055] _Proceedings of the Am. Pharm. Asso._ 1865. 160.

[1056] _Am. Journ. of Pharm._ 1874. 161.—In the same periodical (1876,
335) 300 lbs. are stated to have been collected at Dyersburg, Tenn.

[1057] _Hist. Plant._ iii. (1704), appendix p. 233.

[1058] Chap. 34. sec. 5. § 1. _Aromatic Trees._ For a modern fig., see
Hooker’s _Icones Plant._ 3rd series, i. tab. 1020.

[1059] _Pharm. of India_, 1868. 88.

The tree, according to Bentham,[1060] varies exceedingly in the size,
shape, and texture of the leaves, in the young shoots being silky,
and the spikes silky-villous or woolly, or the whole quite glabrous,
in the short and dense, or long and interrupted spikes, in the size
of the flower, and in the greenish yellow, whitish, pink, or purple
stamens, so that it is difficult to believe all can be forms of a
single species. Yet upon examination, none of these variations are
sufficiently constant or so combined, as to allow of the definition of
distinct races.

The variety growing in Bouro, where the oil of cajuput has been
distilled ever since the time of Rumphius, and known as _M. minor_
Smith, is described by Lesson, who visited the island in 1823, as a
tree resembling an aged olive, with flowers in little globose white
heads, and a trunk the stout bark of which is composed of numerous
satiny layers.

=History=—Rumphius, who passed nearly fifty years in the Dutch
possessions in the East Indies and died at Amboyna in 1702, is the
first to give an account of the oil under notice, and of the tree
from which it is obtained.[1061] From what he says, it appears that
the aromatic properties of the tree are well known to the Malays and
Javanese, who were in the habit of steeping its leaves in oil which
they then impregnated with the smoke of benzoin and other aromatics, so
obtaining an odorous liquid for anointing their heads. They likewise
used cushions stuffed with the leaves, and also laid the latter in
chests to keep away insects.

The fragrance of the foliage having thus attracted the attention of
the Dutch, probably suggested submitting the leaves to distillation.
Rumphius narrates how the oil was obtained in very small quantities,
and was regarded as a powerful sudorific.

In Europe it appears to have been first noticed by J. M. Lochner,[1062]
of Nürnberg, physician to the German Emperor. About the same time
(1717), a ship’s surgeon, returning from the east, sold a provision
of the oil to the distinguished apothecary Johann Heinrich Link at
Leipzig, who published a notice on it and sold it.[1063] It began
then to be quoted in the tariffs of other German apothecaries,[1064]
although it was still reputed a very rare article in 1726.[1065]
Somewhat larger quantities appear to have been soon imported by
Amsterdam druggists.[1066] In Germany the oil took the name of _Oleum
Wittnebianum_, from the recommendations bestowed on it by M. von
Wittneben, of Wolfenbüttel, who was much engaged in natural sciences
and long resident in Batavia.[1067] In France and England, it was
however scarcely known till the commencement of the present century,
though it had a place in the Edinburgh Pharmacopœia of 1788. In the
_London Price Current_, we do not find it quoted earlier than 1813,
when the price given is 3_s._ to 3_s._ 6_d._ per ounce, with a duty of
2_s._ 4½_d._ per ounce.

[1060] _Flora Australiensis_, iii. (1866) 142.

[1061] _Herb. Amboinense_, ii. (1741) cap. 26.

[1062] _Acad. Nat. Curios. Ephemerid. Cent._ v. vi. (Nürnberget, 1717)
157.

[1063] _Sammlung von Natur und Medicin ... Geschichten_, Leipzig, 1719.
257.

[1064] _Pharm. Journ._ vi. (1876) 1023.

[1065] Vater, _Catalog. varior. exoticor. rarissimor...._ Wittenbergæ,
1726.

[1066] Schendus van der Beck, _De Indiæ rarioribus, Act. Nat. Cur._ i.,
appendix (1725) 123.

[1067] Goetz, _Olei Caieput historia—Commercium Litterarium_, 1731. 3;
Martini, _De Oleo Wittnebiano dissertatio_, 1751.

=Manufacture=—In the island of Bouro, in the Molucca Sea, the leaves of
the _Kayu-puti_ or Aij-puti, _i.e._ _White-wood_ trees, are submitted
to distillation with water, the operation being conducted in the
most primitive manner, as already witnessed, about the year 1792, by
Labillardière in his celebrated voyage with Lapérouse. Bickmore,[1068]
an American traveller who passed three months in the island in 1865,
states that it produces about 8,000 bottles of the oil annually, and
that this is almost its only export. The Trade Returns of the Straight
Settlements published at Singapore, show that the largest quantity is
shipped from Celebes, the great island lying west of Bouro.

[1068] _Travels in the East Indian Archipelago_, Lond. 1868. 282.

=Description=—Oil of Cajuput is a transparent mobile fluid, of a
light bluish-green hue, a fragrant camphoraceous odour, and bitterish
aromatic taste. It has a sp. gr. of 0·926, and remains liquid even at
(8°·6 F.)-13° C. It deviates the ray of polarized light to the left. On
diluting it with bisulphide of carbon it becomes turbid.

=Chemical Composition=—The researches of Schmidl (1860) and of
Gladstone (1872) have shown that cajuput oil consists chiefly of
_Hydrate of Cajuputene_ or _Cajuputol_, C₁₀H₁₆, H₂O, which may be
obtained from the crude oil by fractional distillation at 174° C. If it
is repeatedly distilled from anhydrous phosphoric acid, _Cajuputene_,
C₁₀H₁₆, passes over at 160-165° C.; it has an agreeable odour of
hyacinths. After the cajuputene, _Isocajuputene_ distils at 177°,
and _Paracajuputene_ at 310-316°, both agreeing in composition with
cajuputene.

Like most essential oils having the formula C₁₀H₁₆, crude cajuput oil
is capable of forming the crystallized compound C₁₀H₁₆, 3OH₂. This
we have abundantly obtained by mixing 4 parts of the oil with 1 of
alcohol 0·830 sp. gr., and one part of nitric acid 1·20 sp. gr.; the
mixture should be allowed to stand in shallow dishes. By adding 1 vol.
of absolute alcohol to 3 vol. of cajuput oil, and saturating it with
anhydrous hydrochloric gas, crystals of the compound C₁₀H₁₆(HCl)₂ may
be obtained. By vapour of bromine the oil acquires a beautiful green
colour.

If 1 part of iodine be gradually dissolved in cajuput oil, the
temperature being maintained at 50° C., fine green crystals of
(C₁₀H₁₆HI)₂OH₂ are formed. They may be recrystallized from very little
glacial acetic acid, but will not keep for more than a few weeks.

The green tint of the oil is due to copper, a minute proportion of
which metal is usually present in all that is imported. It may be
made evident by agitating the oil with water acidulated by a little
hydrochloric acid. The compounds of copper with inorganic acids being
comparatively of a fainter colour than the cupric salts of organic
acids, the aqueous solution of chloride of copper now formed displays
no longer the fine green tint. To the solution, after it has been
put into a platinum capsule, a little zinc should be added, when the
copper will be immediately deposited on the platinum. The liquid may be
then poured off and the copper dissolved and tested. When the oil is
rectified, it is obtained colourless, but it readily becomes green if
in contact for a short time with metallic copper. The presence of the
metal in the oil may also be shown at once by a scrap of paper which
has been impregnated with fresh tincture of guaiacum wood and dried. If
it is then moistened with water containing 1 per cent. of sulphocyanate
of potassium, the paper turns intensely blue by the contact with the
oil provided the latter contains copper.

Guibourt[1069] has however proved by experiment that the volatile
oil obtained by the distillation of the leaves of several species of
_Melaleuca_, _Metrosideros_ and _Eucalyptus_, has naturally a fine
green hue. It is not improbable that this hue is transient, and that
the contamination with copper is intentional in order to obtain a
permanent green.

=Commerce=—The oil is imported from Singapore and Batavia, packed in
glass beer or wine bottles. From official statements[1070] it appears
that the imports into Singapore during 1871 were as under:—

    From Java            445 gallons
      ”  Manilla         200    ”
      ”  Celebes       3,895    ”
      ”  other places    350    ”
                       -----
               Total   4,890    ”
                       -----

Of this large quantity, the greater portion was re-shipped to Bombay,
Calcutta, and Cochin China.

=Uses=—Cajuput oil is occasionally administered internally as a
stimulant, antispasmodic and diaphoretic: externally as a rubefacient
it is in frequent use.

=Substitutes=—The oil of _Eucalyptus oleosa_ F. Muell. has, we find,
the odour of cajuput; and according to Gladstone it agrees, as well
as the oils of _Melaleuca ericifolia_ Sm. and _M. linariifolia_ Sm.,
almost entirely with cajuput oil, except in optical properties. The
same is probably the case with the oil of _Eucalyptus globulus_ Labill,
which Cloez (1870) states to be dextrogyre. These oils are shipped to
some extent from Australia to Europe, probably as adulterants of other
essential oils.


CARYOPHYLLI.

_Cloves_; F. _Girofles_, _Clous de Girofles_; G. _Gewürznelken_.

=Botanical Origin=—_Eugenia caryophyllata_ Thunberg (_Caryophyllus
aromaticus_ L.), a beautiful evergreen tree, 30 to 40 feet high,
resembling a gigantic myrtle, bearing numerous flowers grouped in small
terminal tricotomous cymes. The flower has an inferior ovary about ½ an
inch long, cylindrical, of a crimson colour, dividing at the top into 4
sepals; and 4 round concave petals larger than the calyx, imbricated in
the bud like a globe, but at length spreading and soon dropping off.

The clove-tree is said to be strictly indigenous only in the five
small islands constituting the proper Moluccas, namely Tarnati, Tidor,
Mortir, Makiyan and Bachian.[1071] These form a chain on the west side
of the large island of Jilolo, where, strange to say, the tree appears
not to exist in a wild state (Crawfurd). According to Rumphius, it
was introduced into Amboyna before the arrival of the Portuguese, and
is still cultivated there and in the neighbouring islands of Haruku,
Saparua and Nusalaut, also in Sumatra and Penang. It is likewise now
found in Malacca, the Mascarene Islands, the islands of Zanzibar and
Pemba on the eastern coast of Africa, and the West Indies.

[1069] _Hist. des Drog._ iii. (1869) 278.

[1070] _Blue Book of the Colony of the Straits Settlements_ for 1871,
Singapore, 1872.

[1071] Though these are the original Moluccas or Clove Islands, the
name has been extended to all islands east of Celebes and west of New
Guinea.

The tree which is grown for the spice appears to be a cultivated
variety, of lower stature and more aromatic than the wild form.

=History=[1072]—The Greek name Καρυόϕυλλον is supposed to refer to
the ball-like _petals_ of the bud, which, as above described, might
be compared to a small nut (κάρυον). But the name is very variably
written, as γαροῦμϕουλ, καρϕούϕουλ, γαρόϕαλα,[1073] whence it becomes
probable that it is not really Greek, but an Asiatic word hellenized.

Cloves have been long known to the Chinese. Mr. Mayers, late Chinese
Secretary to the British Legation at Pekin, has communicated to us the
interesting fact that they are mentioned by several Chinese writers as
in use under the Han dynasty, B.C. 266 to A.D. 220, during which period
it was customary for the officers of the court to hold the spice in the
mouth before addressing the sovereign, in order that their breath might
have an agreeable odour.[1074]

The Sanskrit name is “_Lavanga_,” whence the vernacular Hindustani
“_Laung_.”

The first European author to mention _Caryophyllon_ is Pliny, who
describes it, after _pepper_, as a grain resembling that spice but
longer and more brittle, produced in India, and imported for the sake
of its odour. It is doubtful whether this description really refers to
cloves.

By the 4th century, cloves must have become well known in Europe,
if credence can be placed in a remarkable record preserved by
Vignoli,[1075] which states that the emperor Constantine presented to
St. Silvester, bishop of Rome, A.D. 314-335, numerous vessels of gold
and silver, incense and spices, among which last were 150 pounds of
_Cloves_—a vast quantity for the period.

Kosmas Indicopleustes,[1076] in his _Topographia Christiana_ written
about A.D. 547, states in the account of Taprobane (Ceylon) that silk,
aloes [-wood], cloves (Καρυόϕυλλον) and sandal-wood, besides other
productions, are imported thither from China, and other emporia, and
transmitted to distant regions. Alexander Trallianus,[1077] who was
a friend of Kosmos and a pupil of his father, prescribed in several
receipts 5 or 8 cloves, καρυοϕυλλου κόκκους, from which fact it may be
inferred that at his time (at Rome?) cloves were a very rare article.
A century later, Paulus Ægineta[1078] distinctly described cloves as
_Caryophyllon_—_ex India, veluti flores cujusdam arboris.. odorati,
acres_ ... and much used for a condiment and in medicine.

[1072] For the history of the oil see our article Cortex Cinnamon,
chemical composition.

[1073] Langkavel, _Botanik der späteren Griechen_, Berlin, 1866. 19.

[1074] At this period, the clove was called _Ki shêh hiang_, i.e.
_fowl’s tongue spice_. The modern name _Ting hiang_, i.e. _nail-scent_
or-_spice_, was in use in the 5th or 6th century of our era.

[1075] _Liber Pontificalis, seu de Gestis Romanorum Pontificum_, Romæ,
i. (1724) 94.

[1076] Migne, _Patrologiæ Cursus_, series Græca, lxxxviii. (1860) 446.

[1077] Puschman’s edition (quoted in the appendix) i. 435. 580.
Alexander dedicated his work to his teacher, the father of Cosmas.

[1078] _De re medica_, lib. vii. c. 3.

In the beginning of the 8th century, the same spice is noticed
by Benedictus Crispus,[1079] archbishop of Milan, who calls it
_Cariophylus ater_; and in A.D. 716, it is enumerated with other
commodities in the diploma granted by Chilperic II. to the monastery of
Corbie in Normandy.[1080]

We find cloves among the wares on which duty was levied at Acon (the
modern Acre) in Palestine at the end of the 12th century, at which
period that city was a great emporium of Mediterranean trade.[1081]
They are likewise enumerated in the tariff of Marseilles of A.D.
1228,[1082] in that of Barcelona of 1252[1083] and of Paris, 1296.[1084]

These facts show that the spice was a regular object of commerce at
this period. But it was very costly: the Household Book of the Countess
of Leicester, A.D. 1265,[1085] gives its price as 10_s._ to 12_s._ per
lb., exactly the same as that of saffron. Several other examples of the
high cost of the spice might be adduced.

Of the place of growth of cloves, the first distinct notice seems to be
that of the Arabian geographer Ibn Khurdádbah,[1086] A.D. 869-885, who
names the spice, with cocoa-nuts, sugar, and sandal-wood as produced in
Java. Doubtless he was misinformed, for the clove-tree had not come so
far west at that period. Marco Polo[1087] made the same mistake four
centuries later: finding the spice in Java, he supposed it the growth
of the island.

Nicolo Conti,[1088] a Venetian merchant who lived from A.D. 1424 to
1448 in the Indian Archipelago, learned that cloves are brought to
Java from the island of Banda, fifteen days’ sail further east. With
the arrival of the Portuguese at the commencement of the 16th century,
more accurate accounts of the Spice Islands began to reach Europe;
and Pigafetta,[1089] the companion of Magellan, gave a very good
description of the clove-tree as he observed it in 1521.

The Portuguese had the principal share in the clove trade for nearly a
century. In 1605 they were expelled by the Dutch, who took exclusive
possession of the Moluccas and adopted extraordinary measures for
keeping the traffic in their own hands. Yet notwithstanding this, large
supplies of cloves reached England direct. In 1609 a ship of the East
India Company called the _Consent_ arrived with 112,000 lb., the duty
on which amounted to £1400 and the impost to as much more. The spice
ungarbled was sold at 5_s._ 6_d._ and 5_s._ 9_d._ per lb.—of course, in
bond.[1090]

[1079] _Poematium Medicum_—Migne, _Patrologiæ Cursus_, lxxxix. (1850)
374.

[1080] Pardessus, _Diplomata, Chartæ_, etc., ii. (1849) 309.

[1081] _Recueil des Historiens des Croisades, Lois_, (1843) 173.

[1082] _Méry et Guindon, Hist. des Actes ... de la municipalité de
Marseille_, 1841. 373.

[1083] Capmany, _Memorias sobre la marina etc. de Barcelona_, iii. 170.

[1084] Douet d’Arcq, _Revue archéologique_, ix. (1852) 213.

[1085] _Manners and Household Expenses in England_ (Roxburgh Club),
1841. lii.

[1086] _Le Livre des routes et des provinces_, traduit par C. Barbier
de Meynard, _Journ. Asiat._ sér. 6. tome v. (1865) 227.

[1087] Yule, _Marco Polo_, ii. (1871) 217.—It should however be borne
in mind that the name Java was applied in a general sense by the Arab
geographers to the islands of the Archipelago.

[1088] Kunstmann, _Die Kenntniss Indiens im XVᵗᵉⁿ Jahrhundert_,
München, 1863. 46.

[1089] Ramusio, _Delle navigationi et viaggi_, Venetia, 1554, fol. 404b.

[1090] _Calendar of State Papers, Colonial series, East Indies_, 1862.
181.

To effect their purpose, the Dutch endeavoured to extirpate the
clove-tree from its native islands, and even instituted periodical
expeditions for the purpose of destroying any young trees that might
have accidentally sprung up. This policy, the object of which was to
confine the growth of the spice to a group of small islands of which
Amboyna is the largest, has but very recently been abandoned: though
the cultivation of the spice was free in all other localities, the
_clove parks_ of the Amboyna islands remained the property of the Dutch
Government. The original Moluccas or Clove Islands now produce no
cloves at all.

The enterprise of Poivre, the French governor of Mauritius and
Bourbon, so far eluded the vigilance of the Dutch, that both clove and
nutmeg-trees were introduced into those islands in the year 1770.[1091]
The clove-tree was carried thence to Cayenne in 1793, and to Zanzibar
about the end of the century.

Crawfurd,[1092] in an excellent article of which we have made free use,
aptly remarks that it is difficult to understand how the clove first
came to the notice of foreign nations, considering the well ascertained
fact that it has never been used as a condiment or in any other way by
the inhabitants of the islands of which it is a native. We may observe
however that there were some singular superstitions among the islanders
with regard to the so-called _Royal Clove_ (p. 287), a tree of which on
the island of Makiyan was long supposed to be unique.

=Collection=—The flower-buds of the clove-tree when young are nearly
white, but afterwards become green and lastly bright red, when they
must at once be gathered. This in Zanzibar is done by hand; each clove
is picked singly, a moveable stage the height of the tree being used
to enable the labourers to reach the upper branches. The buds are then
simply dried in the sun, by which they acquire the familiar dark brown
tint of the commercial article. The gathering takes place twice a year;
in the Moluccas where the harvest occurs in June and December, the
cloves are partly gathered by hand, and partly beaten off the tree by
bamboos on to cloths spread beneath. The annual yield of a good tree is
about 4½ pounds, but sometimes reaches double that quantity.

=Description=—Cloves are about ⁶/₁₀ of an inch in length, and consist
of a long cylindrical calyx dividing above into 4 pointed spreading
sepals which surround 4 petals, closely imbricated as a globular bud
about ²/₁₀ of an inch in diameter.

The petals which are of lighter colour than the rest of the drug and
somewhat translucent from numerous oil-cells, spring from the base of
a 4-sided epigynous disc, the angles of which are directed towards the
lobes of the calyx. The stamens which are very numerous, are inserted
at the base of the petals and are arched over the style. The latter
which is short and subulate, rises from a depression in the centre of
the disc. Immediately below it and united with the upper portion of
the calyx is the ovary, which is 2-celled and contains many ovules.
The lower end of the calyx (_hypanthium_) has a compressed form; it
is solid but has its internal tissue far more porous than the walls.
The whole calyx is of a deep rich brown, has a dull wrinkled surface,
a dense fleshy texture, and abounds in essential oil which exudes on
simple pressure with the nail. Cloves have an agreeable spicy odour,
and a strong biting aromatic taste.

[1091] Tessier, _Sur l’importation du Giroflier des Moluques aux
Isles de France, de Bourbon et de Sechelles, et de ces isles à
Cayenne_.—_Observations sur la physique_, Paris, Juillet, 1779.

[1092] _Dictionary of the Indian Islands_, 1856, article _Clove_.

The varieties of cloves occurring in commerce do not exhibit any
structural differences. Inferior kinds are distinguished by being less
plump, less bright in tint, and less rich in essential oil. In London
price-currents, cloves are enumerated in the order of value thus:
Penang, Bencoolen, Amboyna, Zanzibar.

=Microscopic Structure=—A transverse section of the lower part of a
clove shows a dark rhomboid zone, the tissue on either side of which
is of a lighter hue. The outer layer beneath the epidermis exhibits a
large number of oil-cells, frequently as much as 300 mkm. in diameter.
About 200 oil-cells may be counted in one transverse section, so that
the large amount of essential oil in the drug is well shown by its
microscopic characters. The above-mentioned zone is chiefly made up of
about 30 fibro-vascular bundles, another stronger bundle traversing the
centre of the clove. The fibro-vascular bundles, as well as the tissue
bordering the oil-cells, assume a greenish black hue by alcoholic
perchloride of iron. Oil-cells are also largely distributed in the
leaves, petals and even the stamens of Eugenia.

=Chemical Composition=—Few plants possess any organ so rich in
essential oil as the drug under consideration. The oil known in
pharmacy as _Oleum Caryophylli_, which is the important constituent
of cloves, is obtainable to the extent of 16 to 20 per cent. But to
extract the whole, the distillation must be long continued, the water
being returned to the same material.

The oil is a colourless or yellowish liquid with a powerful odour
and taste of cloves, sp. gr. 1·046 to 1·058. It is a mixture of a
hydrocarbon, and an oxygenated oil called _Eugenol_, in variable
proportions. The former which is termed _light oil of cloves_ and comes
over in the first period of the distillation, has the composition
C₁₅H₂₄, a sp. gr. of 0·918 and boils at 251° C. It deviates the plane
of polarization slightly to the left, and is not coloured on addition
of ferric chloride; it is of a rather terebinthinaceous odour.

Eugenol, sometimes called _Eugenic Acid_, has a sp. gr. of 1·087 at 0°
C., and possesses the full taste and smell of cloves. Its boiling point
is 247°·5 C. With alkalis, especially ammonia and baryta, it yields
crystallizable salts. Eugenol may therefore be prepared by submitting
the crude oil of cloves to distillation with caustic soda; the “light
oil” distils then, the eugenol, being now combined with sodium, remains
in the still. It will be obtained on addition of an acid and again
distilling. Eugenol is devoid of rotatory power, whence the crude oil
of cloves, of which eugenol is by far the prevailing constituent, is
optically almost inactive. The constitution of eugenol is given by the

                   {OCH₃
    formula C₆H₃   {OH        .
                   {CH·CH·CH₃

It belongs to the phenol class, and has also been met with in the
fruits of Pimenta officinalis (see next article), in the Bay leaves, in
Canella bark (see page 75), in the leaves and flower buds of Cinnamomum
zeilanicum and in Brazilian clove-bark (_Dicypellium caryophyllatum_
Nees).

Eugenol can be converted into _Vanillin_ (see Fructus Vanillæ).

The water distilled from cloves is stated to contain, in addition to
the essential oil, another body, _Eugenin_, which sometimes separates
after a while in the form of tasteless, crystalline laminæ, having the
same composition as eugenol.[1093] We have never met with it.

According to Scheuch (1863), oil of cloves also (sometimes) contains a
little _Salicylic acid_,

         {OH
    C₆H₄ {     ,
         {COOH

which may be removed by shaking the oil with a solution of carbonate of
ammonium.

_Caryophyllin_, C₂₀H₃₂O, is a neutral, tasteless, inodorous substance,
crystallizing in needle-shaped prisms. We have obtained it in small
quantity, by treating with boiling ether cloves, which we had
previously deprived of most of their essential oil by small quantities
of alcohol. E. Mylius (1873) obtained from it by nitric acid, crystals
of _Caryophyllinic Acid_, C₂₀H₃₂O₆.

_Carmufellic Acid_ obtained in colourless crystals, C₁₂H₂₀O₁₆, in 1851
by Muspratt and Danson after digesting an aqueous extract of cloves
with nitric acid, is a product of this treatment and not a natural
constituent of cloves.

Cloves contain a considerable proportion of gum; also a tannic acid not
yet particularly examined.

=Production and Commerce=—Of late years the principal locality for
the production of cloves has been the islands of Zanzibar and Pemba
on the east coast of Africa, which until very recently were capable
of producing a maximum crop of 10½ millions of pounds in a single
season. On the 15th April 1872, Zanzibar was visited by a hurricane of
extraordinary violence, by which about five-sixths of the clove-trees
in the island were destroyed; and although the plantations are being
renewed, many years must elapse before the crop can resume its
former importance. Pemba, which is distant from Zanzibar 25 miles,
and produced about half as much of the spice as that island, did not
appreciably suffer from the storm.

The crop on these islands fluctuates, a good year alternating with a
bad one. This is partly shown in the imports of Bombay, the great mart
of Zanzibar produce, which have been as follows:—

      1869-70       1870-71       1871-72       1872-73
    45,642 cwt.   21,968 cwt.   43,891 cwt.   25,185 cwt.

The quantity of cloves shipped from Bombay to the United Kingdom is
comparatively small, being in 1871-72, 3279 cwt.; in 1872-73, 3271 cwt.

The imports of cloves to the United Kingdom are from one million to
four million pounds annually.

Cloves are also largely shipped direct from Zanzibar to the United
States and Hamburg. A small amount is taken in native vessels to the
Red Sea ports; these are packed in raw hides. Those for the European
and American markets are shipped in mat bags made of split cocoa-nut
leaf.

[1093] Gmelin, _Chemistry_, xiv. (1860) 201.

The clove trade of the Moluccas has been for many years in the hands
of the Dutch Government, which, by its restrictive policy, assumed
practically the position of growers, disposing of their produce through
the Netherlands Trading Company at auctions held in Holland twice a
year. This system having been abolished in 1872, has proved disastrous
to the trade it was designed to protect, and to such a degree that the
produce of cloves in the Moluccas is but a tenth of what it was in
the early days of their intercourse with Europe. The crop of the four
islands, Amboyna, Haruku, Saparua, and Nusalaut, the only Moluccas in
which the tree is cultivated, was reckoned in 1854 as 510,912 lb.

The export of cloves from Java in 1871 was 1397 peculs[1094] (186,226
lb.). The French island of Réunion which from 1825 to 1849 used to
produce annually as much as 800,000 kilogrammes (1,764,571 lb.), now
yields almost none, owing chiefly to the frequent hurricanes.

=Uses=—As a remedy, cloves are unimportant, though in the form of
infusion or distilled water they are useful in combination with other
medicines. The essential oil which sometimes relieves toothache is a
frequent ingredient of pill-masses. The chief consumption of cloves is
as a culinary spice.

=Substitutes=—1. _Clove Stalks_—_Festucœlvel Stipites Caryophylli_, in
French _Griffes de Girofle_, in German _Nelkenstiele_, were an article
of import into Europe during the middle ages, when they were chiefly
known by their low Latin name of _fusti_, or the Italian _bastaroni_.
Thus under the statutes of Pisa,[1095] A.D. 1305, duty was levied not
only on cloves (_garofali_), but also on _Folia et fusti garofalorum_.
Pegolotti[1096] a little later names both as being articles of trade at
Constantinople. Clove _Leaves_ are enumerated[1097] as an import into
Palestine in the 12th century; they are also mentioned in a list of the
drugs sold at Frankfort[1098] about the year 1450; we are not aware
that they are used in modern times.

As to Clove Stalks, they are still a considerable object of trade,
especially from Zanzibar, where they are called by the natives
_Vikunia_. They taste tolerably aromatic, and yield 4 to 6·4 per cent.
of volatile levogyre oil; they are used for adulterating the _Ground
Cloves_ sold by grocers. Such an admixture may be detected by the
microscope, especially if the powder after treatment with potash be
examined in glycerin. If clove stalks have been ground, thick-walled
or stone-cells will be found in the powder; such cells do not occur in
cloves. Powdered allspice is also an adulterant of powdered cloves; it
also contains stone-cells, but in addition numerous starch granules
which are entirely wanting in cloves.

2. _Mother Cloves, Anthophylli_—are the _fruits_ of the clove-tree,
and are ovate-oblong berries about an inch in length and much less
rich in essential oil than cloves. Though occasionally seen in the
London drug sales in some quantity, they are not an article of regular
import.[1099] As they contain very large starch granules, their
presence as an adulteration of ground cloves would be revealed by the
microscope.

[1094] _Consular Reports_, Aug. 1873. 952.

[1095] Bonaini, _Statuti inediti della città di Pisa dal xii. al xiv.
secolo_, iii. (1857) 106.

[1096] See p. 235, note 2.

[1097] _Recueil des Historiens des Croisades, Lois_, ii. (1843) 173.

[1098] Flückiger, _Die Frankfurter Liste_, Halle, 1873. 11. 38.

[1099] We find in the fortnightly price current of a London drug-broker
under date Nov. 27, 1873, the announcement of the sale of 1,050 bags
of Mother Cloves at 2_d._ to 3_d._ per lb., besides 4,200 packages of
Clove Stalks at 3_d._ to 4_d._ per lb.

3. _=Royal Cloves=_—Under this name or _Caryophyllum regium_, a curious
monstrosity of the clove was formerly held in the highest reputation,
on account of its rarity and the strange stories told respecting
it.[1100] Specimens in our possession show it to be a very small
clove, distinguished by an abnormal number of sepals and large bracts
at the base of the calyx-tube, the corolla and internal organs being
imperfectly developed.


FRUCTUS PIMENTÆ.

_Semen Amomi_; _Pimento_, _Allspice_, _Jamaica Pepper_; F. _Poivre de
la Jamaïque_, _Piment des Anglais_, _Toute-épice_; G. _Nelkenpfeffer_,
_Nelkenköpfe_, _Neugewürz_.

=Botanical Origin=—_Pimenta officinalis_ Lindley[1101] (_Myrtus
Pimenta_ L., _Eugenia Pimenta_ DC.), a beautiful evergreen tree,
growing to about 30 feet in height, with a trunk 2 feet in
circumference, common throughout the West India Islands. In Jamaica, it
prefers limestone hills near the sea, and is especially plentiful on
the north side of the island.

=History=—The high value placed on the spices of India sufficiently
explains the interest with which aromatic and pungent plants were
regarded by the early explorers of the New World; while the eager
desire to obtain these lucrative commodities is shown by the names
_Pepper_, _Cinnamon_, _Balsam_, _Melegueta_, _Amomum_, bestowed on
productions totally distinct from those originally so designated.

Among the spices thus brought to the notice of Europe were the
little dry berries of certain trees of the myrtle tribe, which had
some resemblance in shape and flavour to peppercorns, and hence were
named _Pimienta_,[1102] corrupted to _Pimenta_ or _Pimento_. It was
doubtless a drug of this kind, if not our veritable allspice, that
was given to Clusius in 1601 by Garret, a druggist of London, and
described and figured by the former in his _Liber Exoticorum_.[1103]
A few years later it began to be imported into England, being, as
Parkinson[1104] says, “obtruded for _Amomum_” (_Round Cardamom_), so
that “some more audacious than wise ... put it in their compositions
instead of the right.” Francesco Redi mentioned the fruits as
_Pimienta de Chapa_; Chiapas, now the south-eastern department of
Mexico, bordering Guatemala. Redi states that the spice was also
called _Pimienta de Tavasco_ from the adjoining department of Tabasco.
According to Sloane[1105] (1691) it was commonly sold by druggists for
_Carpobalsamum_. Ray (1693) distinguished the spice as a production of
Jamaica under the name of _Sweet-scented Jamaica Pepper_ or _Allspice_,
and states it to be abundantly imported into England, and in frequent
use as a condiment, though not employed in medicine. The spice had a
place in the London Pharmacopœia as early as 1721.

[1100] Rumphius in his letter from Amboina, Sept. 20, 1696, to Dr.
Schröck, in _Ephemerides Acad. Cæs. Leopold. Decur._ iii. Frankfurt
and Leipzig. 1700. p. 308, with figure.—Also Rumphius, _Herb. Amb._
ii. (1742) 11. tab. 2.—See also Hasskarl, _Neuer Schlüssel zu Rumph’s
Herb. Amb._, Halle, 1866; Berg, _Linnæa_, 1854. 137; Valmont de Bomare,
_Dict. d’Hist. Nat._ iii. (1775) 70.

[1101] Fig. in Bentley and Trimen, _Med. Plants_, part 20 (1877).

[1102] _Pimienta_, the Spanish for _pepper_, is derived
from _pigmentum_, a general name in mediæval Latin for
_spicery_.—_Malaguetta_ (see article Grana Paradisi) is also a name
which has been transferred by the Spaniards and Portuguese to the drug
under notice.

[1103] Lib. i. c. 17.

[1104] _Theatrum Botanicum_ (1640) 1567.

[1105] _Description of the Pimienta or Jamaica Pepper-tree._—_Phil.
Trans._ xvii. No. 191.

The consumption of Pimento has been enormous. In the year 1804-5,
the quantity shipped from the British West Indies was 2,257,000 lb.,
producing on import duty a net revenue of £38,063.[1106]

=Production and Commerce=—The spice found in commerce is furnished
wholly by the island of Jamaica. A plantation, there called a _Pimento
walk_, is a piece of natural woodland stocked with the trees, which
require but little attention. The flowers appear in June, July, and
August, and are quickly succeeded by the berries, which are gathered
when of full size but still unripe. This is performed by breaking off
the small twigs bearing the bunches. These are then spread out, and
exposed to the sun and air for some days, after which the stalks are
removed, and the berries are fit for being packed.

By an official document[1107] it appears that, in the year 1871, the
amount of land in Jamaica cropped with pimento was 7,178 acres. In that
year the island exported of the spice 6,857,838 lb., value £28,574. Of
this quantity Great Britain took 4,287,551 lb., and the United States
2,266,950 lb. In 1875 the export was 57,500 cwts., valued at £40,250,
of which 10,894 cwts. only went to the United States.

[1106] _Parliamentary Return_, March 1805, quoted in Young’s _West
India Commonplace Book_, 1807. 79.

[1107] _Blue Book_ for Jamaica, printed 1872.

=Description=—Allspice is a small, dry globular berry, rather variable
in size, measuring ³/₁₀ to less than ²/₁₀ of an inch in diameter. It is
crowned by a short style, seated in a depression, and surrounded by 4
short thick sepals; generally however the latter have been rubbed off,
a scar-like raised ring marking their former position. The berry has a
woody shell or pericarp, easily cut, of a dark ferruginous brown, and
rugose by reason of minute tubercles filled with essential oil. It is
two-celled, each cell containing a single, reniform, exalbuminous seed,
having a large spirally curved embryo. The seed is aromatic, but less
so than the pericarp.

Allspice has an agreeable, pungent, spicy flavour, much resembling that
of cloves.

=Microscopic Structure=—The outer layer of the pericarp, immediately
beneath the epidermis, contains numerous large cells filled with
essential oil. The parenchyme further exhibits thick-walled cells
loaded with resin, and smaller cells enclosing crystals of oxalate of
calcium. The whole tissue is traversed by small fibro-vascular bundles.
The seeds are also provided with a small number of oil-cells, and
contain starch granules.

=Chemical Composition=—The composition of pimento resembles in many
points that of cloves. The berries yield to the extent of 3 to 4½
per cent. a volatile oil, sp. gr. 1·037 (Gladstone), having the
characteristic taste and odour of the spice, and known in the shops as
_Oleum Pimentæ_. We have found it to deviate the ray of polarized light
2° to the left, when examined in a column of 50 mm.

Oeser (1864), whose experiments have been confirmed by Gladstone
(1872), has shown that oil of pimento has substantially the same
composition as oil of cloves; salicylic acid has not been found.
Pimento is rich in tannin, striking with a persalt of iron an inky
black. Its decoction is coloured deep blue by iodine, showing the
presence of starch. Dragendorff (1871) pointed out the existence in
allspice of an extremely small quantity of an alkaloid, having somewhat
the odour of coniine.

=Uses=—Employed as an aromatic clove; a distilled water (_Aqua
Pimentæ_) is frequently prescribed. The chief use of pimento is as a
culinary spice.

=Substitute=—The Mexican spice called _Pimienta de Tabasco_ (_Piment
Tabago_ Guibourt) is somewhat larger and less aromatic than Jamaica
allspice. Analogous products are afforded by _Pimenta acris_
Wight[1108] (_Myrcia acris_ DC, _Amomis acris_ Berg), the _Bay-berry_
tree, and _P. Pimento_ Griseb. The oil of bay-berry consists of eugenol
and a hydrocarbon, possibly identical with the “light oil of cloves”
(p. 284), but present in a larger amount. _Bay rum_, much used in the
United States by the perfumers, is an alcoholic tincture flavoured with
oil of bay-berry.




GRANATEÆ.


CORTEX GRANATI FRUCTUS.

_Cortex Granati_; _Pomegranate Peel_; F. _Ecorce de Grenades_; G.
_Granatschalen_.

=Botanical Origin=—_Punica Granatum_ L., a shrub or low tree, with
small deciduous foliage and handsome scarlet flowers. It is indigenous
to North-western India, and the counties south and south-west of the
Caspian to the Persian Gulf and Palestine, and grows wild in the hills
of Western Sindh in elevations of 4000 feet, in Balutchistan to 6000
feet, also in the east flank of Soliman range. The trunk is short,
rarely over 20 feet high. The tree has long been cultivated, and is
now found throughout the warm parts of Europe, and in the subtropical
regions of both hemispheres.

=History=—The pomegranate has been highly prized by mankind from
the remotest antiquity, as is shown by the references to it in the
Scriptures,[1109] and by the numerous representations of the fruit in
the sculptures of Persepolis and Assyria,[1110] and on the ancient
monuments of Egypt.[1111] It was probably introduced into the south
of Italy by Greek colonists, and is named as a common fruit-tree by
Porcius Cato[1112] in the 3rd century B.C. The peel of the fruit was
recognized as medicinal by the ancients, and among the Romans was in
common use for tanning leather,[1113] as it still is in Tunis.

[1108] Figured in Bentley and Trimen, part 20.—The fruit of this
species is easily distinguished, being crowned by 5-calyx lobes.

[1109] _Exodus_ xxviii. 33, 34; _Numbers_ xx. 2; _Deut._ viii 8;
_Cant._ iv. 13; viii. 2.

[1110] Layard, _Nineveh and its Remains_, ed. 5, ii. (1849) 296.

[1111] Wilkinson, _Ancient Egyptians_, ii. (1837) 142.

[1112] Nisard’s edition, Paris, 1877, capp. 7. 127. 133.

[1113] See also Hehn, _Kulturpflanzen_, Berlin, 1877, 206.

=Description=—The fruit of the pomegranate tree is a spherical,
somewhat flattened and obscurely six-sided berry, the size of a common
orange and often much larger, crowned by the thick, tubular, 5-to
9-toothed calyx. It has a smooth, hard, coriaceous skin, which when the
fruit is ripe, is of a brownish yellow tint, often finely shaded with
red. Membranous dissepiments, about 6 in number meeting in the axis of
the fruit, divide the upper and larger portion into equal cells. Below
these a confused conical diaphragm separates the lower and smaller
half, which in its turn is divided into 4 or 5 irregular cells. Each
cell is filled with a large number of grains, crowded on thick spongy
placentæ, which in the upper cells are parietal but in the lower appear
to be central. The grains, which are about ½ an inch in length, are
oblong or obconical and many-sided, and consist of a thin transparent
vesicle containing an acid, saccharine, red, juicy pulp, surrounding an
elongated angular seed.

The only part of the fruit used medicinally is the peel, _Cortex
Granati_ of the druggists, which in the fresh state is leathery. When
dry as imported, it is in irregular, more or less concave fragments,
some of which have the toothed, tubular calyx still enclosing the
stamens and style. It is ⅒ to ¹/₂₀ of an inch thick, easily breaking
with a short corky fracture; externally it is rather rough, of a
yellowish-brown or reddish colour. Internally it is more or less brown
or yellow, and honey-combed with depressions left by the seeds. It has
hardly any odour, but has a strongly astringent taste.

=Microscopic Structure=—The middle layer of the peel consists of large
thin-walled and elongated, sometimes even branched cells, among which
occur thick-walled cells and fibro-vascular bundles. Both the outer
and the inner surface are made up of smaller, nearly cubic and densely
packed cells. Small starch granules occur sparingly throughout the
tissue, as well as crystals of oxalate of calcium.

=Chemical Composition=—The chief constituent is tannin, which in an
aqueous infusion of the dried peel produces with perchloride of iron
an abundant dark blue precipitate. The peel also contains sugar and a
little gum. Dried at 100° C. and incinerated, it yielded us 5·9 per
cent. of ash.

=Uses=—Pomegranate peel is an excellent astringent, now almost obsolete
in British medicine. Waring[1114] asserts that when combined with opium
and an aromatic, as cloves, it is a most useful remedy in the chronic
dysentery of the natives of India, as well as in diarrhœa.

[1114] _Pharm. of India_, 1868. 93. 447.


CORTEX GRANATI RADICIS.

_Pomegranate-root Bark_; F. _Ecorce de racine de Grenadier_; G.
_Granatwurzelrinde_.

=Botanical Origin=—_Punica Granatum_ L., see page 289.

=History=—In addition to the particulars regarding the pomegranate
tree given in the preceding article, the following which concern the
drug under notice may be stated.

A decoction of the root of the pomegranate was recommended by
Celsus,[1115] Dioscorides,[1116] and Pliny[1117] for the expulsion
of tapeworm; but the remedy had fallen into complete oblivion, until
its use among the Hindus attracted the notice of Buchanan[1118] at
Calcutta about the year 1805. This physician pointed out the efficacy
of the root-bark, which was further shown by Fleming and others.
Pomegranate-root is known to have been long used for a similar purpose
by the Chinese.[1119]

Though the medicine is admitted to be efficient, and is employed with
advantage in India where it is easily procured both genuine and fresh,
it is hardly ever administered in England, the extract of male-fern
being generally preferred; but it has a place in several continental
pharmacopœias.

=Description=—The bark occurs in rather thin quills or fragments, 3
to 4 inches long. Their outer surface is yellowish-grey, sometimes
marked with fine longitudinal striations or reticulated wrinkles, but
more often furrowed by bands of cork, running together in the thickest
pieces into broad flat conchoidal scales. The inner surface, which is
smooth or marked with fine striæ and is of a greyish yellow, has often
strips of the tough whitish wood attached to it. The bark breaks short
and granular; it has a purely astringent taste, but scarcely any odour.

=Microscopic Structure=—On a transverse section, the liber is seen to
be the prevailing part of the cortical tissue. The former consists of
alternating layers of two kinds of cells—one of them loaded with tufted
crystals of oxalate of calcium, the other filled with starch granules
and tannic matter. The bark is traversed by narrow medullary rays, and
very large sclerenchymatous cells are scattered through the liber.
Touched with a dilute solution of a persalt of iron, the bark assumes a
dark blackish blue tint.

=Chemical Composition=—The bark contains, according to Wackenroder
(1824), more than 22 per cent. of tannic acid, which Rembold (1867)
has ascertained to consist for the most part of a peculiar variety
called _Punico-tannic Acid_, C₂₀H₁₆O₁₃; when boiled with dilute
sulphuric acid, it is resolved into _Ellagic Acid_, C₁₄H₈O₉, and sugar.
Punico-tannic acid is accompanied by common tannic acid, yielding,
by means of sulphuric acid, gallic acid, which appears sometimes
to pre-exist in the bark. If a decoction of pomegranate bark is
precipitated by acetate of lead, and the lead is separated from the
filtered liquid, the latter on evaporation yields a considerable amount
of mannite. This is probably the _Punicin_ or _Granatin_ of former
observers.

[1115] _De Medicina_, lib. iv. c. 17.

[1116] Lib. i. c. 153.

[1117] Lib. xxiii. c. 60.

[1118] _Edinb. Med. and Surg. Journ._, iii. (1807) 22.

[1119] Debeaux, _Pharmacie et Mat. Méd. des Chinois_, 1865. 70.

The tænicide power is due, according to Tanret (1878) to
_Pelletierine_, C₈H₁₅NO, a liquid dextrogyre alkaloid, boiling at 180°
to 185° C. It can be obtained colourless by evaporating its ethereal
solution in a vacuum, but in the open air becomes yellow. Pelletierine,
so called in honour of Pelletier, is readily soluble in water, alcohol
or chloroform, and has a somewhat aromatic odour. Several of its
salts are crystallizable, yet extremely hygroscopic. The yield of the
root-bark was about ½ per cent. of the alkaloid, or about 2 per cent.
of crystallized sulphate from trees grown near Troyes, in the Champagne.

=Uses=—A decoction, followed by a purgative, is stated by Waring[1120]
and others to be most efficient for the expulsion of the tapeworm. The
_fresh_ bark is said to be preferable to the dried.

=Adulterations=—The commercial drug frequently consists partly or
entirely of the bark of the stem or branches, characterized by its less
abundant cork-formation, which exhibits longitudinal bands or ridges
of light brownish cork, but not conchoidal exfoliations. The middle
cortical layer is somewhat more developed, and contains in the outer
cells deposits of chlorophyll. The cambial zone is not distinctly
observable. Such bark is reputed to be less active than that of the
root, but we are not aware that the fact has ever been proved.

The bark of _Buxus sempervirens_ and of _Berberis vulgaris_ are
somewhat similar to the drug under notice, but their decoctions are not
affected by salts of iron.




CUCURBITACEÆ.


FRUCTUS ECBALLII.

_Fructus Elaterii_; _Elaterium Fruit_, _Squirting Cucumber_, _Wild
Cucumber_; F. _Concombre purgatif ou sauvage_; G. _Springgurke_.

=Botanical Origin=—_Ecballium[1121] Elaterium_ A. Richard (_Momordica
Elaterium_ L.), a coarse, hispid, fleshy, decumbent plant without
tendrils, having a thick white perennial root. It is common throughout
the Mediterranean region, extending eastward as far as Southern Russia
and Persia, and westward to Portugal. It succeeds well in Central
Europe, and is cultivated to a small extent for medicinal use at
Mitcham and Hitchin in England.

=History=—Theophrastus mentions the plant under notice by the name
of Σίκυος ἄγριος. It is also particularly noticed by Dioscorides,
who explicitly describes the singular process for making elaterium
(ἐλατήριον), which was almost exactly like that followed at the present
day.

The Wild or Squirting Cucumber was well known and cultivated in gardens
in England as early as the middle of the 16th century.[1122]

[1120] _Indian Annals of Med. Science_, vi. (1859); _Pharmacopœia of
India_, 1868. 93.

[1121] _Ecballium_ from ἐκβάλλω, I expel, in allusion to the expulsion
of the seeds: often erroneously written _Ecbalium_.

[1122] Turner’s _Herball_, 1568, part i. 180.

=Description=—The fruit is ovoid-oblong, nodding, about 1½ inch long,
hispid from numerous short fleshy prickles terminating in white
elongated points. It is attached by a long scabrous peduncle, is fleshy
and green while young, becoming slightly yellowish when mature; it is
3-celled and contains numerous oblong seeds lodged in a very bitter
succulent pulp. The fruit when ripe separates suddenly from the stalk,
and at the same moment the seeds and juice are forcibly expelled
from the aperture left by the detached peduncle. This interesting
phenomenon[1123] is due to the process of exosmosis, by which the juice
of the outer part of the fruit gradually passes through the strong
contractile tissue which lines the central cavity, until the pressure
becomes so great that the cell gives way at its weakest point. This
point is that at which the peduncle is articulated with the fruit; and
it is the sudden and powerful contraction of the elastic tissue when
relieved from pressure that occasions the violent expulsion of the
contents of the central cavity.

For the preparation of the officinal elaterium, the fruit has to be
employed while still somewhat immature, for the simple reason that it
would be impossible to gather it so as to retain its all-important
juice if left till quite ripe. When it is sliced longitudinally as
in making elaterium, some of the juice is expelled by virtue of the
endosmotic action already described, as can easily be seen on examining
the contracted lining of the sliced fruit.

Pereira observes[1124] that if the juice of a fruit is received on a
plate of glass, it is seen to be nearly colourless and transparent.
In a few minutes however, by exposure to the air, it becomes slightly
turbid, and small white coagula are formed in it. By slow evaporation,
minute rhomboidal crystals make their appearance: these are _elaterin_.

Hot, dry weather favours the development of the active principle of the
drug.[1125]

=Microscopic Structure=—The middle layer of the fruit is built up of
large somewhat thick-walled cells, traversed by a few fibro-vascular
bundles. The former abound in small starch grains, and also contain
granules of albuminous matter.

=Chemical Composition=—The experiments of Clutterbuck (1819) proved
that the active properties of the elaterium plant reside chiefly,
though not exclusively, in the juice that surrounds the seeds; and it
is to this juice and to the medicinal product which it yields, that the
attention of chemists has been hitherto directed.

The juice obtained by lightly pressing the sliced fruits is at first
greenish and slightly turbid. After having been set aside a few hours,
it yields a deposit, which has to be collected on calico, rapidly
drained with gentle pressure between layers of bibulous paper and
porous bricks, and dried in a warm place. The substance thus obtained
is the _Elaterium_ of pharmacy.[1126] The method recommended by
Clutterbuck[1127] involves no pressing. The juice of the sliced fruit
is saved, and the pulp, scooped out by the thumb of the operator, is
thrown on a sieve and slightly washed with pure water. From these
liquors, elaterium is deposited.

[1123] I have not yet seen Yule’s paper on the dehiscence of this fruit
in the _Journ. of Anat. and Physiology_, 1877. The structure of the
testa of the seed is explained by Fickel, in the _Botanische Zeitung_,
1876. 774.—F. A. F..

[1124] _Elem. of Mat. Med._ ii. (1853) 1745.

[1125] Having had to procure elaterium fruits at Mitcham in the very
fine summer of 1868, I was told that the people occupied in slicing
the fruits had never suffered so severely from their work as in that
year.—D. H.

[1126] There is a genus of _Cucurbitaceæ_ founded by Linnæus, also
called _Elaterium_.

[1127] _Lond. Med. Repository_, xii. (1820) 1.

Elaterium occurs in irregular cake-like fragments, light, friable, and
opaque; when new, of a bright pale green, becoming by age greyish and
exhibiting minute crystals on the surface. It has a herby tea-like
odour and a very bitter taste. The produce is extremely small: 240 lb.
of fruit gathered at Mitcham, 1Oth August 1868, yielded 4⅝ ounces of
elaterium = 0·123 per cent.

Elaterium consists, according to Pereira, of _Elaterin_, to which the
activity of the drug is due, contaminated with green colouring matter,
cellular tissue, and starch, together with a little of the residue of
the bitter liquor from which these substances were deposited. Yet, in
our opinion, this description is not applicable to the best varieties
of elaterium. We have examined elaterium carefully prepared in the
laboratory of Messrs. Allen and Hanburys, London, and a fine specimen
imported from Malta. Both are devoid of starch, as well as of cellular
tissue, but were seen to be largely made up of crystals. The first
sample contained 12 per cent. of water, and yielded after drying, 8·4
per cent. of ash.

The most interesting principle of elaterium is _Elaterin_, C₂₀H₂₈O₅,
discovered about the year 1831 by Morries, and independently by
Hennell. The best method of obtaining it, according to our experience,
is to exhaust elaterium with chloroform. From this solution, a white
crystalline deposit of elaterin is immediately separated by addition
of ether. It should be washed with a little ether, and recrystallized
from chloroform. We have thus obtained 33·6 per cent. of pure elaterin
from the above-mentioned elaterium of London, and 27·6 per cent. from
that of Malta. Elaterin crystallizes in hexagonal scales or prisms; it
has an extremely bitter, somewhat acrid taste. It is readily soluble in
boiling alcohol, amylic alcohol, bisulphide of carbon, or chloroform.
Its alcoholic solutions are neutral and are not precipitated by tannin,
nor by any metallic solution. It is but very little coloured by cold
concentrated sulphuric acid.

Elaterin is the drastic principle of _Ecballium_; if to its boiling
alcoholic solution, solid caustic potash is added, the liquid thus
obtained is stated by Buchheim (1872) to be no longer precipitable by
water. The elaterin is then in fact converted into an acid body, which
may be separated by supersaturating the solution with a mineral acid.
The principle thus obtained has been found by Buchheim to be devoid of
drastic power.

The fresh juice of the fruits was found by Köhler (1869) to contain
95 per cent. of water, 3 to 3·5 of organic and 1 to 1·6 of inorganic
constituents. The same chemist observed that the percentage of elaterin
gradually diminished as the season advanced, until in the month of
September he was unable to obtain any of it whatever.

Walz (1859) found in the juice of the fruits and herb of _Ecballium_,
as well as in that of _Cucumis Prophetarum_ L., a second crystallizable
bitter principle, _Prophetin_, and the amorphous substances _Ecballin_
or _Elateric Acid_, _Hydro-elaterin_, and _Elateride_, all of which
require further examination.[1128] Prophetin is a glucoside,—not so
the other principles. The four together constitute, according to Walz,
8·7 per cent. of elaterium, which moreover contains about the same
percentage of pectic matter.

[1128] Gmelin’s _Chemistry_, xvii. (1866) 335-367.

=Uses=—Squirting cucumbers are only employed for making elaterium,
which is a very powerful hydragogue cathartic.[1129] Elaterin is not
employed in medicine, but seeing how much elaterium is liable to vary
from climate or season, it might probably be introduced into use with
advantage.


FRUCTUS COLOCYNTHIDIS.

_Colocynth_, _Coloquintida_, _Bitter Apple_; F. _Coloquinte_; G.
_Coloquinthe_.

=Botanical Origin=—_Citrullus Colocynthis_ Schrader (_Cucumis
Colocynthis_ L.)—The colocynth gourd is a slender scabrous plant with a
perennial root, native of warm and dry regions in the Old World, over
which it has an extensive area.

Commencing eastward, it occurs in abundance in the arid districts
of the Punjab and Sind, in sandy places on the Coromandel coast, in
Ceylon, Persia as far north as the Caspian, in Arabia (Aden), Syria,
and in some of the Greek islands. It is found in immense quantities
in Upper Egypt and Nubia, spreading itself over sand hillocks of the
desert after each rainy season. It further extends throughout North
Africa to Morocco and Senegambia, in the Cape de Verd Islands, and on
maritime sands in the south-east of Spain and Portugal. Finally, it is
said to have been collected in Japan.

=History=—Colocynth was familiar to the Greek and Roman, as well as
to the Arabian physicians; it also occurs in Susruta (“Indravārunī”);
and if we may judge by the mention of it in an Anglo-Saxon herbal of
the 11th century,[1130] was not then unknown in Britain. The drug was
collected in Spain at an early period, as is evident from an Arabic
calendar of A.D. 961.[1131]

The plant has been long cultivated in Cyprus, and its fruit is
mentioned in the 14th century as one of the more important products of
the island.[1132] Tragus (1552) figured the plant, and stated that the
fruit is imported from Alexandria.

=Description=—The colocynth plant bears a gourd of the size and shape
of an orange, having a smooth, marbled-green surface. It is sometimes
imported simply dried, in which case it is of a brown colour; but
far more usually it is found in the market peeled with a knife and
dried. It then forms light, pithy, nearly white balls, which consist
of the dried internal pulp of the fruit with the seeds imbedded in
it. This pulp is nearly inodorous, but has an intensely bitter taste,
perceptible by reason of its dust when the drug is slightly handled.
The balls are generally more or less broken; when dried too slowly they
have a light brown colour.

[1129] Clutterbuck says ⅛ of a grain purges violently.

[1130] Cockayne, _Leechdoms_, etc., i. (1865) 325.

[1131] _Le Calendrier de Cordoue_, publié par R. Dozy, Leyde, 1873. 92.

[1132] De Mas Latrie, _Hist. de l’ile de Chypre_, iii. (1852-61) 498.

The seeds are disposed in vertical rows on 3 thick parietal placentæ,
which project to the centre of the fruit, then divide and turn back,
forming two branches directed towards one another. Owing to this
structure, the fruit easily breaks up vertically into 3 wedges in each
of which are lodged 2 rows of dark brown seeds. The seeds, of which a
fruit contains from 200 to 300, are of flattened ovoid form, ³/₁₀ of
an inch long by ²/₁₀ broad, not bordered. The testa which is hard and
thick, having its surface minutely granulated, is marked on each side
of its more pointed end by two furrows directed towards the hilum. The
seed, as in other _Cucurbitaceæ_, is exalbuminous, and has thick oily
cotyledons, enclosing an embryo with short straight radicle directed
towards the hilum.

Colocynth fruits are mostly supplied by wholesale druggists, broken
up and having the seeds removed, the drug in such case being called
_Colocynth Pulp_ or _Pith_.

=Microscopic Structure=—The pulp is made up of large thin-walled
parenchymatous cells, their outer layer consisting of rows of smaller
cells more densely packed. The tissue is irregularly traversed by
fibro-vascular bundles, and also exhibits numerous large intercellular
spaces. The cells contain but an insignificant amount of minute
granules, to which neither iodine nor a persalt of iron imparts any
coloration. The tissue is not much swollen by water, although one part
of the pulp easily retains from 10 to 12 parts of water like a sponge.

=Chemical Composition=—The bitter principle has been isolated in 1847
by Hübschmann.[1133] He observed that alcohol removes from the fruit a
large amount of _resin_. By submitting this solution to distillation,
the bitter principle remains partly in the aqueous liquid, partly
in the resin, from which the “_Colocynthin_” is to be extracted by
boiling water. The whole solution was then concentrated and mixed
with carbonate of potassium, when a thickish viscid liquid separated.
Hübschmann dried it and redissolved it in a mixture of 1 part of strong
alcohol and 8 parts of ether. After treatment with charcoal, the
solvents were distilled and the remaining bitter principle removed by
means of water. This on evaporating afforded 2 per cent. of the pulp of
a yellow extremely bitter powder, readily soluble in water or alcohol,
not in pure ether. Colocynthin is precipitated from its aqueous
solution by carbonate of potassium. Colocynthin was further extracted
by Lebourdais (1848) by evaporating the aqueous infusion of the fruit
with charcoal, and exhausting the dried powder with boiling alcohol.

[1133] _Schweizerische Zeitschrift für Pharmacie_, 1858. 216.

Again, another method was followed by Walz (1858). He treated alcoholic
extract of colocynth with water, and mixed the solution firstly with
neutral acetate of lead, and subsequently with basic acetate of
lead. From the filtered liquid the lead was separated by means of
sulphuretted hydrogen, and then tannic acid added to it. The latter
caused the colocynthin to be precipitated; the precipitate washed and
dried was decomposed by oxide of lead, and finally the colocynthin was
dissolved out by ether.

Walz thus obtained about ¼ per cent. of a yellowish mass or tufts,
which he considered as possessing crystalline structure and to which he
gave the name _Colocynthin_. He assigns to it the formula C₅₆H₈₄O₂₃,
which in our opinion requires further investigation. Colocynthin is
a violent purgative; it is decomposed according to Walz by boiling
dilute hydrochloric acid, and then yields _Colocyntheïn_, C₄₄H₆₄O₁₃,
and grape sugar. The same chemist termed _Colocynthitin_ that part of
the alcoholic extract of colocynth which is soluble in ether but not in
water. Purified with boiling alcohol, colocynthitin forms a tasteless
crystalline powder.

The pulp perfectly freed from seeds and dried at 100° C., afforded us
11 per cent. of ash; the seeds alone yield only 2·7 per cent. They
have, even when crushed, but a faint bitter taste, and contain 17 per
cent. of fat oil.

The fresh leaves of the plant if rubbed emit a very unpleasant smell.

=Commerce=—The drug is imported from Mogador, Spain and Syria.

=Uses=—In the form of an extract made with weak alcohol, and combined
with aloes and scammony, colocynth is much employed as a purgative. The
seeds, roasted or boiled, are the miserable food of some of the poorest
tribes of the Sahara.[1134]

The people of the Berber upon the Nile make a curious application
for the tar they obtain from the fruit. The latter is heated in an
earthen vessel with a hole in it; the tar drips through to another
vessel and is fit for smearing leather water-bags. The bad smell of
the tar (and of the leaves) prevents the camels from cutting open the
water-bags.[1135]

=Substitutes=—_Cucumis trigonus_ Roxb. (_C. Pseudo-colocynthis_ Royle),
a plant of the plains of Northern India, with spherical or elongated,
sometimes obscurely trigonous, bitter fruits, prostate _rooting_ stems,
and deeply divided leaves, resembles the colocynth gourd and has been
mistaken for it. Another species named by Royle _C. Hardwickii_, and
known to the natives of India as _Hill Colocynth_, has oval oblong
bitter fruits, but leaves entirely unlike those of the _Citrullus
Colocynthis_.




UMBELLIFERÆ.


HERBA HYDROCOTYLES.

_Indian Hydrocotyle_, _Indian Pennywort_; F. _Bevilacqua_.

=Botanical Origin=—_Hydrocotyle asiatica_ L., a small creeping
herb,[1136] with slender jointed stems, common in moist places
throughout tropical Asia and Africa, ascending in Abyssinia to
elevations of 6,000 feet. It also occurs in America from South Carolina
to Valdivia, in the West Indies, the islands of the Pacific, New
Zealand, and Australia.

=History=—Hydrocotyle is called in Sanskrit _mandūka-parnī_, in Hindi
_khulakhudi_. The former name denotes various plants, but is thought
to refer in Susruta to the plant under notice (Dr. Rice). It was known
to Rheede[1137] by its Malyalim name of _Codagam_ (or _Kutakan_),
and also to Rumphius.[1138] It has been long used medicinally by the
natives of Java and of the Coromandel coast. In 1852, Boileau, a French
physician of Mauritius, pointed out its virtues in the treatment of
leprosy,[1139] for which disease it was largely tried in the hospitals
of Madras by Hunter[1140] in 1855. It has since been admitted to a
place in the _Pharmacopœia of India_.

[1134] See my paper on _Cucumis Colocynthis_ considered as a nutritive
plant in the _Archiv der Pharmacie_, 201 (1872) 235.—F. A. F.

[1135] Col. Grant, Botany of the Speke and Grant expedition, _Journ.
Linn. Soc._ xxix. pt. 2 (1873) 77.

[1136] Fig. in Bentley and Trimen. _Med. Plants_, pt. 24, 1877.

[1137] _Hort. Mal._ x. tab. 46.

[1138] _Herb. Amboin._ v. 169.

[1139] Bouton, _Med. Plants of Mauritius_, 1857. 73-83.

[1140] _Medical Reports_, Madras, 1855. 356.

=Description=[1141]—The peduncles and petioles are fasciculed; the
latter are frequently 2½ inches long; the peduncles are shorter and
bear a 3-or 4-flowered simple umbel with very short rays. The leaves
are reniform, crenate, ½ to 2 inches in longest diameter, 7-nerved,
glabrous, or when young somewhat hairy on the under side. The fruit
is laterally compressed, orbicular, acute on the back; the mericarps
reticulated, sometimes a little hairy, with 3 to 5 curved ribs; they
are devoid of vittæ. The main root is an inch or two long, but roots
are also thrown out by the procumbent stem.

When fresh, the herb is said to be aromatic and of a disagreeable
bitter and pungent taste; but these qualities appear to be lost in
drying.

=Chemical Composition=—An analysis of hydrocotyle has been made by
Lépine, a pharmacien of Pondicherry,[1142] who found it to yield a
somewhat peculiar body which he called _Vellarin_, from _Valālrai_,
the Tamil name of the plant, and regarded as its active principle.
Vellarin, which is said to be obtainable from the dry plant to the
extent of 0·8 to 1·0 per cent., is an oily, non-volatile liquid with
the smell and taste of fresh hydrocotyle, soluble in spirit of wine,
ether, caustic ammonia, and partially also in hydrochloric acid.
These singular properties do not enable us to rank vellarin in any
well-characterized class of organic compounds.

By exhausting 3 ounces of the dried herb with rectified spirit, we did
not obtain any thing like vellarin, but simply a green extract almost
entirely soluble in warm water, and containing chiefly tannic acid,
which produced an abundant green precipitate with salts of iron. With
caustic potash, neither the herb nor its extract evolved any nauseous
odour. The dried plant afforded Lépine 13 per cent. of ash.

=Uses=—As an alterative tonic, hydrocotyle is allowed to be of some
utility, but the power claimed for it by Boileau of curing leprosy is
generally denied. Dorvault[1143] regards it as belonging to the class
of narcotico-acrid poisons such as hemlock, but we see no evidence to
warrant such an opinion. Besides being administered internally, it is
sometimes locally applied in the form of a poultice. Boileau says that
the entire plant is preferable to the leaves alone.[1144]

=Substitutes (?)=—_H. rotundifolia_ Roxb., another species common in
India, may be known from _H. asiatica_ by having 10 or more flowers
in an umbel and much smaller fruits. The European _H. vulgaris_ L.,
easily distinguishable from the allied tropical species just described,
by having its leaves orbicular and peltate (not reniform), is said to
possess deleterious properties.

[1141] Drawn up from Indian specimens.

[1142] _Journ. de Pharm._ xxviii. (1855) 47.

[1143] _L’Officine_ (1872) 554.

[1144] It is probably by oversight that the _leaves alone_ are ordered
in the _Pharmacopœia of India_.


FRUCTUS CONII.

_Hemlock fruits_; F. _Fruits de Ciguë_; G. _Schierlingsfrucht_.

=Botanical Origin=—_Conium maculatum_ L., an erect biennial herbaceous
plant, flourishing by the sides of fields and streams, and in neglected
spots of cultivated ground, throughout temperate Europe and Asia.
It occurs in Asia Minor and the Mediterranean islands, and has been
naturalized in North and South America. But the plant is very unevenly
distributed, and in many districts is entirely wanting. It is found in
most parts of Britain from Kent and Cornwall to the Orkneys.

=History=—Κώνειον, occurring as early as the fourth or fifth century
B.C. in the Greek literature, was the plant under notice, at least in
most cases. The famous hemlock potion of the Greeks by which criminals
were put to death[1145] was essentially composed of the juice of this
plant. The old Roman name of Conium was _Cicuta_; it prevails in the
mediæval Latin literature, but was applied, about 1541, by Gesner
(and probably before him by others) to _Cicuta virosa_ L., another
umbelliferous plant which is altogether wanting in Greece and in
Southern Europe generally, and does not contain any poisonous alkaloid.
To avoid the confusion arising from the same appellation given to
these widely different and quite dissimilar plants, Linnæus, in 1737,
restoring the classical Greek name, called it Conium maculatum.[1146]

Hemlock was used in Anglo-Saxon medicine. It is mentioned as early as
the 1Oth century in the vocabulary of Alfric, archbishop of Canterbury,
as “_Cicuta_, hemlic,”[1147] and also in the Meddygon Myddfai. Hemlock
is derived from the Anglo-Saxon words “hem,” border, shore, and “leác”
leek. Its use in modern medicine is due chiefly to the recommendation
of Störck of Vienna, since whose time (1760) the plant has been
much employed. The extreme uncertainty and even inertness of its
preparations, which had long been known to physicians and had caused
its rejection by many, have been recently investigated by Harley.[1148]
The careful experiments of this physician show what are the real powers
of the drug, and by what method its active properties may be utilized.

=Description=—The fruit has the structure usual to the order; it is
broadly ovoid, somewhat compressed laterally, and constricted towards
the commissure, attenuated towards the apex, which is crowned with a
depressed stylopodium. As met with in the shops, it consists of the
separated mericarps which are about ⅛ of an inch long. The dorsal
surface of these has 5 prominent longitudinal ridges, the edges of
which are marked with little protuberances giving them a jagged or
crenate outline, which is most conspicuous before the fruits are fully
ripe. The furrows are glabrous but slightly wrinkled longitudinally;
they are devoid of vittæ. When a mericarp is cut transversely, the seed
exhibits a reniform outline, due to a deep furrow in the albumen on the
side of the commissure.

[1145] See Imbert-Gourbeyre, _De la mort de Socrate par la Ciguë_,
Paris, 1876.

[1146] An extensive paper has been devoted by Albert Regel to the
_History of Conium_ and _Cicuta_ in the _Bulletin de la Soc. imp. des
Naturalistes de Moscou_, tome li. (1876, first part) 155-203 and lii.
(1877) first part, 1-52.

[1147] _Volume of Vocabularies_, edited by Wright, 1857. 31.

[1148] _Pharm. Journ._ viii. (1867) 460-710; ix. (1868) 53.

The fruits of hemlock are dull greenish grey, and have but little taste
and smell; but when triturated with a solution of caustic alkali they
evolve a strong and offensive odour.

=Microscopic Structure=—Hemlock fruits differ from other fruits of
the order by the absence of vittæ.[1149] In the endocarp, there is a
peculiar layer of small nearly cubic cells surrounding the albumen. The
cells of the endocarp are loaded with a brown liquid consisting chiefly
of conine and essential oil.

=Chemical Composition=—The most important constituent of the fruits of
hemlock _Conine_ or _Conia_, C₈H₁₄NH, a limpid colourless oily fluid,
0·846 sp. gr. at 12°·5 C. It has a strong alkaline reaction, and boils
at 170° C. in an atmosphere devoid of oxygen, without decomposition. It
was first observed by Giseke at Eisleben, Saxony, in 1827, recognized
as an alkaloid by Geiger in 1831, and more amply studied by Wertheim
in 1856 and 1862. To obtain it, an alcoholic extract is submitted
to distillation with a little slaked lime. The product should be
neutralized with oxalic acid, and the oxalate of conine removed by
absolute alcohol mixed with a little ether, oxalate of ammonium being
insoluble. The oxalate of the alkaloid shaken with caustic lye and
ether, affords the conine, on evaporating the solvent and distilling
the alkaloid in a current of dry hydrogen. In the plant it is combined
with an acid (malic?), and accompanied by ammonia, as well as by a
second, less poisonous crystallizable base, called _Conhydrine_,
C₈H₁₇NO, which may be converted into conine by abstraction of the
elements of water. From these alkaloids a liquid non-poisonous
hydrocarbon, _Conylene_, C₈H₁₄, has been separated by Wertheim. Even in
nature one hydrogen atom of conine is frequently replaced by methyl,
CH₃; and commercial conine commonly contains, as shown by A. von Planta
and Kekulé, methyl-conine, C₈H₁₄NCH₃. Lastly there is present in
hemlock fruits a third alkaloid having probably the composition C₇H₁₃N.

As to the yield of conine, it varies according to the development
of the fruits, but it is at best only about ⅕ per cent. According
to Schroff (1870), the fruits are most active just before maturity,
provided they are gathered from the biennial plant. At a later stage,
conine is probably partly transformed into conhydrine, which however is
present in but very small proportion,—about 1¼ per mille at most.

In its deleterious action, conine resembles nicotine, but is much less
powerful.

Schiff (1871-1872) has artificially produced an alkaloid partaking of
the general properties of conine, and having the same composition; but
it is optically indifferent. Conine, on the other hand, we find turns
the plane of polarization to the right.

The fruits of hemlock contain also a volatile oil which appears devoid
of poisonous properties; it exists in but small quantity and has not
yet been fully examined.

[1149] See _Moynier de Villepoix_, _Annales des Sciences naturelles_,
Botanique, v. (1878) 348.

=Uses=—The fruits of hemlock are the only convenient source of the
alkaloid conine. They were introduced into British medicine in 1864,
as a substitute for the dried leaf in making the tincture. But it has
been shown that a tincture, whether of leaf or fruit, is a preparation
of very small value, and that it is far inferior to the preserved juice
of the herb. It has however been pointed out by W. Manlius Smith,[1150]
and his observations have been confirmed by Harley,[1151] that the
_green unripe fruits_ possess more than any other part the peculiar
energies of the plant, and that they may even be dried without loss of
activity. A medicinal fluid extract of considerable power has been made
from them by Squibb of New York.


FOLIA CONII.

_Hemlock Leaves_; F. _Feuilles de Ciguë_; G. _Schierlingsblätter_.

=Botanical Origin=—_Conium maculatum_ L., see p. 299.

=History=—See p. 299.

=Description=—Hemlock in its first year produces only a tuft of leaves;
but in its second a stout erect stem which often grows to the height
of 5 or 9 feet, is much branched in its upper part, and terminates in
small umbels, each having about 12 rays. The lower leaves, often a foot
in length, have a triangular outline, and a hollow stalk as long as the
lamina, clasping the stem at its base with a membranous sheath. Towards
the upper portion of the plant, the leaves have shorter stalks, are
less divided, and are opposite or in cohorts of 3 to 5. The involucral
bracts are lanceolate, reflexed, and about a ¼ of an inch long. Those
of the partial umbel are turned towards the outside, and are always 3
in number. The larger leaves are twice or thrice pinnate, the ultimate
segments being ovate-oblong, acute, and deeply incised.

The stem is cylindrical and hollow, of a glaucous green, generally
marked on its lower part with reddish-brown spots. The leaves are of a
dull dark green, and like the rest of the plant quite glabrous. They
have when bruised a disagreeable fœtid smell.

For medicinal purposes the plant should be taken when in full
blossom.[1152]

=Chemical Composition=—The leaves of hemlock contain, though in
exceedingly small proportion, the same alkaloids as the fruits. Geiger
obtained from the fresh herb not so much as one ten-thousandth part
of conine. It is probable however that the active constituents vary
in proportion considerably, and that a dry and sunny climate promotes
their development.

The same observer, as well as Pereira, has pointed out that hemlock
leaves when dried are very frequently almost devoid of conine, and
the observation is supported by the more recent experiments of Harley
(1867). It has also been shown by the last named physician, that the
inspissated juice known in pharmacy as _Extractum Conii_ usually
contains but a mere trace of alkaloid, the latter having in fact been
dissipated by the heat employed in reducing the juice to the required
consistence. On the other hand, Harley has proved that the juice of
fresh hemlock preserved by the addition of spirit of wine, as in the
_Succus Conii_ of the Pharmacopœia, possesses in an eminent degree the
poisonous properties of the plant.

[1150] _Trans. of the New York State Medical Society_ for 1867.

[1151] _The old Vegetable Neurotics_, Lond. 1869.

[1152] The London herbalists often collect it while much of the
inflorescence is still in bud, in which state it affords far more of
leaf than when well matured; but it is in the latter condition that the
plant is to be preferred.

The entire amount of nitrogen in dried hemlock leaves was estimated by
Wrightson (1845) at 6·8 per cent.; the ash at 12·8 per cent. The latter
consists mainly of salts of potassium, sodium, and calcium, especially
of sodium chloride and calcium phosphate.

A ferment-oil may be obtained from _Conium_; it is stated to have an
odour unlike that of the plant and a burning taste, and not to be
poisonous.[1153]

[1153] Gmelin, _Chemistry_, xiv. 405.

=Uses=—Hemlock administered in the form of _Succus Conii_, has a
peculiar sedative action on the motor nerves, on account of which it
is occasionally prescribed. It was formerly much more employed than at
present, although the preparations used were so defective that they
could rarely have produced the specific action of the medicine.

=Plants liable to be confounded with Hemlock=—Several common plants of
the order _Umbelliferæ_ have a superficial resemblance to _Conium_, but
can be discriminated by characters easy of observation. One of these is
_Æthusa Cynapium_ L. or _Fool’s Parsley_, a common annual garden weed,
of much smaller stature than hemlock. It may be known by its primary
umbel having no involucre, and by its partial umbel having an involucel
of 2 or 3 linear pendulous bracts. The ridges of its fruit moreover are
not wavy or crenate as in hemlock, nor is its stem spotted.

_Chærophyllum Anthriscus_ L. (_Anthriscus vulgaris_ Pers.) and two
or three other species of _Chærophyllum_ have the lower leaves not
unlike those of hemlock, but they are _pubescent_ or _ciliated_. The
fruits too are _linear-oblong_, and thus very dissimilar from those of
_Conium_.

The latter plant is in fact clearly distinguished by its smooth spotted
stem, the character of its involucral bracts and fruit, and finally by
the circumstance that when triturated with a few drops of solution of
caustic alkali, it evolves conine (and ammonia), easily observable as
a white fume when a rod moistened with strong acetic acid is held over
the mortar.


FRUCTUS AJOWAN.

_Semen Ajavæ vel Ajouain_; _Ajowan_, _True Bishop’s weed_.

=Botanical Origin=—_Carum Ajowan_ Bentham et Hooker (_Ammi copticum_
L. _Ptychotis coptica_ et _Pt. Ajowan_ DC.)—an erect annual herb,
cultivated in Egypt and Persia, and especially in India where it is
well known as _Ajvan_ or _Omam_.

=History=—The minute spicy fruits of the above-named plant have been
used in India from a remote period, as we may infer from their being
mentioned in Sanskrit writings, as, for instance, by the grammarian
Pānini, in the third century B.C. (or later?), and in Susruta.

Owing to their having been confounded with some other very small
umbelliferous fruits, it is difficult to trace them precisely in many
of the older writers on materia medica. It is however probable that
they are the _Ammi_ which Anguillara[1154] met with in 1549 at Venice,
where it had then, exceptionally, been imported in small quantity from
Alexandria. It is also, we suppose, the _Ammi perpusillum_ of Lobel
(1571), in whose time the drug was likewise imported from Egypt, as
well as the _Ammi alterum parvum_, the seed of which Dodonæus (1583)
mentions as being “minutissimum, acre et fervidum.” Dale,[1155] who
says it is brought from Alexandria, reports it as very scarce in the
London shops. Under the name of _Ajave Seeds_, the drug was again
brought into notice in 1773 by Percival,[1156] who received a small
quantity of it from Malabar as a remedy for colic; and still more
recently, it has been favourably spoken of by Fleming, Ainslie,
Roxburgh, O’Shaughnessy, Waring and other writers who have treated of
Indian materia medica.

=Description=—Ajowan fruits, like those of other cultivated
_Umbelliferæ_, vary somewhat in size and form. The largest kind much
resemble those of parsley, being of about the same shape and weight.
The length of the large fruits is about ⅒, of the smaller form scarcely
¹/₁₆ of an inch. The fruits are greyish brown, plump, very rough on the
surface, owing to numerous minute tubercles (_fructus muriculatus_).
Each mericarp has five prominent ridges, the intervening channels being
dark brown, with a single vitta in each. The commissural side bears two
vittæ. The fruits when rubbed exhale a strong odour of thyme (_Thymus
vulgaris_ L.), and have a biting aromatic taste.

=Microscopic Structure=—The oil-ducts of ajowan are very large, often
attaining a diameter of 200 mkm. The ridges contain numerous spiral
vessels; the blunt tubercles of the epidermis are of the same structure
as those in anise, but comparatively larger and not pointed. The tissue
of the albumen exhibits numerous crystalloid granules of albuminous
matter (aleuron), distinctly observable in polarized light.

=Chemical Composition=—The fruits on an average afford from 4 to
4·5 per cent. of an agreeable aromatic, volatile oil; at the same
time there often collects on the surface of the distilled water a
crystalline substance, which is prepared at Oojein and elsewhere in
Central India, by exposing the oil to spontaneous evaporation at a low
temperature. This stearoptene, sold in the shops of Poona and other
places of the Deccan, under the name of _Ajwain-ka-phul_, i.e. _flowers
of ajwain_, was showed by Stenhouse (1855) and by Haines (1856) to be
identical with

                 {OH
    Thymol, C₆H₃ {CH₃, as contained in Thymus vulgaris.
                 {C₃H₇

We obtained it by exposing oil of our own distillation, first rectified
from chloride of calcium, to a temperature of 0° C., when the oil
deposited 36 per cent. of thymol in superb tabular crystals, an inch
or more in length. The liquid portion, even after long exposure to a
cold some degrees below the freezing point, yielded no further crop.
We found the thymol thus obtained began to melt at 44° C., yet using
somewhat larger quantities, it appeared to require fully 51° C. for
complete fusion. On cooling, it continues fluid for a long time, and
only recrystallizes when a crystal of thymol is projected into it.

[1154] _Semplici_, Vinegia, 1561. 130.

[1155] _Pharmacologia_, 1693. 211.

[1156] _Essays, Medical and Experimental_, ii. (1773) 226.

Thymol is more conveniently and completely extracted from the oil by
shaking it repeatedly with caustic lye, and neutralizing the latter.

The oil of ajowan, from which the thymol has been removed, boils
at about 172°, and contains cymene (or cymol), C₁₀H₁₄, which, with
concentrated sulphuric acid, affords cymen-sulphonic acid, C₁₀H₁₃SO₂OH.
The latter is not very readily crystallizable, but forms crystallized
salts with baryum, calcium, zinc, lead, which are abundantly soluble
in water. In the oil of ajowan no constituent of the formula C₁₀H₁₆
appears to be present; mixed with alcohol and nitric acid (see p. 279)
it at least produces no crystals of terpin.

The residual portions of the oil, from which the cymene has been
distilled, contains another substance of the phenol class different
from thymol.

We have found that neither the thymol nor the liquid part of ajowan oil
possesses any rotatory power.

=Uses=—Ajowan is much used by the natives of India as a
condiment.[1157] The distilled water which has been introduced into
the _Pharmacopœia of India_, is reputed to be carminative, and a good
vehicle for nauseous medicines. It has a powerful burning taste, and
would seem to require dilution. The volatile oil may be used in the
place of oil of thyme, which it closely resembles.

Ajowan seeds are largely imported into Europe since thymol has been
universally introduced into medical practice (see Folia Thymi). They
have proved much more remunerative for the manufacture of thymol than
Thymus vulgaris. The largest quantities, we believe, of thymol have
been made from ajowan at Leipzig.

=Substitutes=—Under the name _Semen Ammi_, the very small fruits of
_Ammi majus_ L. and of _Sison Amomum_ L. have been often confounded
with those of Ajowan; but the _absence of hairs_ on the two former,
not to mention some other differences, is sufficient to negative any
supposition of identity.

The seeds of _Hyoscyamus niger_ L. being called in India
_Khorāsāniajwān_, a confusion might arise between them and true
ajowan; though the slightest examination would suffice to show the
difference.[1158]

[1157] Roxburgh, _Flor. Ind._ ii. (1832) 91.

[1158] To such a mistake may probably be referred the statement of
Irvine (_Account of the Mat. Med. of Patna_, 1848, p. 6) that the seeds
of henbane are “used in food as carminative and stimulant”!


FRUCTUS CARUI.

_Semen Carui vel Carvi_; _Caraway Fruits_, _Caraway Seeds_, _Caraways_;
F. _Fruits ou Semences de Carvi_; G. _Kümmel_.

=Botanical Origin=—_Carum Carvi_ L., an erect annual or biennial plant
not unlike a carrot, growing in meadows and moist grassy land over the
northern and midland parts of Europe and Asia, but to what extent truly
wild cannot be always ascertained.

It is much cultivated in Iceland, and is also apparently wild.[1159]
It grows throughout Scandinavia, in Finland, Arctic, Central, and
Southern Russia, Persia, and in Siberia. It appears as a wild plant
in many parts of Britain (Lincolnshire and Yorkshire), but is also
cultivated in fields, and may not be strictly indigenous. The caraway
is found throughout the eastern part of France, in the Pyrenees,
Spain, Central Europe, Armenia, and the Caucasian provinces; and it
grows wild largely in the high alpine region of Lahul, in the Western
Himalaya.[1160]

[1159] Babington in _Journ. of Linn. Soc._, Bot. xi. (1871) 310.

[1160] Aitchison in _Journ. of Linn. Soc._, Bot., x. (1869) 76. 94.

But the most curious fact in the distribution of _Carum Carvi_ is its
occurrence in Morocco, where it is largely cultivated about El Araiche,
and round the city of Morocco.[1161] The plant differs somewhat from
that of Europe; it is an annual with a single erect stem, 4 feet high.
Its foliage is more divided, and its flowers larger, with shorter
styles and on more spreading umbels than the common caraway, and its
fruit is more elongated.[1162]

=History=—The opinion that this plant is the Κάρος of Dioscorides,
and that, as Pliny states, it derived its name from Caria (where it
has never been met with in modern times) has very reasonably been
doubted.[1163]

Caraway fruits were known to the Arabians, who called them _Karawya_,
a name they still bear in the East, and the original of our words
_caraway_ and _carui_, as well as of the Spanish _alcarahueya_. In the
description of Morocco by Edrisi,[1164] 12th century, it is stated that
the inhabitants of Sidjilmâsa (the south-eastern province) cultivate
cotton, _cumin_, _caraway_, henna (_Lawsonia alba_ Lamarck). In the
Arab writings quoted by Ibn Baytar,[1165] himself a Mauro-Spaniard of
the 13th century, caraway is compared to cumin and anise. The spice
probably came into use about this period. It is not noticed by St.
Isidore, archbishop of Seville in the 7th century, though he mentions
fennel, dill, coriander, anise, and parsley; nor is it named by St.
Hildegard in Germany in the 12th century. Neither have we found any
reference to it in the Anglo-Saxon _Herbarium of Apuleius_, written
_circa_ A.D. 1050,[1166] or in other works of the same period, though
cumin, anise, fennel, and dill are all mentioned.

On the other hand, in two German medicine-books of the 12th and 13th
centuries[1167] there occurs the word _Cumich_, which is still the
popular name of caraway, in Southern Germany; and _Cumin_ is also
mentioned. In the same period the seeds appear to have been used by
the Welsh physicians of Myddvai.[1168] Caraway was certainly in use in
England at the close of the 14th century, as it figures with coriander,
pepper and garlick in the _Form of Cury_, a roll of ancient English
cookery compiled by the master-cooks of Richard II. about A.D. 1390.

[1161] Leared in _Pharm. Journ._ Feb. 8, 1873. 623.

[1162] I have cultivated the Morocco plant in 1872 and 1873 by the side
of the common form.—D. H.

[1163] Dierbach, _Flora Apiciana_, 1831. 53.

[1164] _Description de l’Afrique et de l’Espagne trad. par Dozy et M.
J. de Goeje_, Leyde, 1866, 75. 97. 150.

[1165] Sontheimer’s translation, ii. 368.

[1166] _Leechdoms, etc. of Early England_, i. (1864).

[1167] Pfeiffer, _Zwei deutsche Arzneibücher aus dem xii. und xiii.
Jahrhundert_, Wien 1863. 14.

[1168] _Meddygon Myddfai_, 158. 354.

The oriental names of caraway show that as a spice it is not a
production of the East:—thus we find it termed _Roman_ (i.e.
_European_), _Armenian_, _mountain_, or _foreign Cumin_; _Persian_ or
_Andalusian_ _Caraway_; or _foreign Anise_. And though it is now sold
in the Indian bazaars, its name does not occur in the earlier lists of
Indian spices.

=Cultivation=[1169]—In England, the caraway is cultivated exclusively
in Kent and Essex, on clay lands. It was formerly sown mixed with
coriander and teazel seed, but now with the former only. The plant,
which requires the most diligent and careful cultivation, yields in its
second year a crop which is ready for harvesting in the beginning of
July. It is cut with a hook at about a foot from the ground, and a few
days afterwards may be thrashed. The produce is very variable, but may
be stated at 4 to 8 cwt. per acre.

=Description=—The fruits, which in structure correspond to those of
other plants of the order, are laterally compressed and ovate. The
mericarps which hang loosely suspended from the arms of the carpophore,
are in the English drug about ⅙ of an inch in length and ¹/₂₀ in
diameter, subcylindrical, slightly arched, and tipped with the conical,
shrivelled stylopodium. They are marked with five pale ridges, nearly
half as broad as the shining, dark brown furrows, each of which is
furnished with a conspicuous vitta; a pair of vittæ separated from each
other by a comparatively thin fibro-vascular bundle, occurs on the
commissure.

Caraways are somewhat horny and translucent; when bruised, they evolve
an agreeable fragrance resembling that of dill, and they have a
pleasant spicy taste. In the London market, they are distinguished as
_English_, _Dutch_, _German_, and _Mogador_, the first sort fetching
the highest price. The fruit varies in size, tint and flavour; the
English is shorter and plumper than the others; the Mogador is paler,
stalky, and elongated—often ³/₁₀ of an inch in length.

=Microscopic Structure=—Caraways are especially distinguished by their
enormous vittæ, which in transverse section display a triangular
outline, the largest diameter, _i.e._ the base of the triangle, often
attaining as much as 300 mkm. Even those of the commissure are usually
not smaller.

=Chemical Composition=—Caraways contain a volatile oil, which the Dutch
drug affords to the extent of 5·5 per cent., that grown in Germany to
the amount of 7 per cent.[1170]; in Norway 5·8 per cent. have also been
obtained from indigenous caraways.[1171] The position and size of the
vittæ account for the fact that comminution of the fruits previous to
distillation, does not increase the yield of oil.

Völckel (1840) showed that the oil is a mixture of a hydrocarbon
C₁₀H₁₆, and an oxygenated oil, C₁₀H₁₄O. Berzelius subsequently termed
the former _Carvene_ and the latter _Carvol_.

Carvene, constituting about one-third of the crude oil, boils at 173°
C., and forms with dry hydrochloric gas crystals of C₁₀H₁₆ + 2HCl.
It has been ascertained by us that carvene, as well as carvol, has a
dextrogyrate power, that of carvene being considerably the stronger;
there are probably not many liquids exhibiting a stronger dextrogyrate
rotation. Carvene is of a weaker odour than carvol, from which it has
not yet been absolutely deprived; perfectly pure carvene would no
doubt prove no longer to possess the specific odour of the drug. By
distilling it over sodium it acquires a rather pleasant odour; its
spec. gr. at 15° C. is equal to 0·861.

[1169] Morton, _Cyclop. of Agriculture_, i. (1855) 390.

[1170] Information obligingly supplied by Messrs. Schimmel & Co.,
Leipzig.

[1171] Schübeler, _Pflanzenwelt Norwegens_. Christiania, 1863-1875. 85.

Carvol at 20° C. has a sp. gr. of 0·953; it boils at 224° C.; the same
oil appears to occur in dill (see Fructus Anethi), and an oil of the
same percental constitution is yielded by the spearmint. The latter
however deviates the plane of polarization to the left. If 4 parts of
carvol, either from caraways, dill, or spearmint, are mixed with 1 part
of alcohol, sp. gr. 0·830, and saturated with sulphuretted hydrogen,
crystals of (C₁₀H₁₄C)₂SH₂ are at once formed as soon as a little
ammonia is added.[1172]

Oil of caraway of inferior quality is obtained from the refuse of the
fruit; we find it less dextrogyrate than the oil from the fruits alone;
this is due to the admixture of oil of turpentine before distilling.

If the carvol is distilled there remains in the still a thickish
residue, from which a substance of the phenol class may be extracted by
caustic lye.

Oil of caraway distilled in England from home-grown caraways is
preferred in this country. On the Continent, that extracted from the
caraways of Halle and Holland is considered to be of finer flavour than
the oil obtained from those of Southern Germany.

The immature fruit of caraway is rich in tannic matter, striking blue
with a salt of iron. It occurs abundantly in the tissue around the
oil-ducts, where the presence of sugar may be also detected by alkaline
tartrate of copper. Sugar occurs likewise in the embryo, but not in the
albumen, in which latter protein substances predominate.

=Production and Commerce=—Caraways are exported from Finmark, the most
northerly province of Norway; from Finland and Russia. In Germany, the
cultivation, recommended by Gleditsch in 1776, is now largely carried
on in Moravia, and in Prussia, especially in the neighbourhood of
Halle. The districts of Erfurt and Merseburg, also in Prussia, are
stated to yield annually about 30,000 cwt. Dutch caraways are produced
in the provinces of North Holland, Gelderland and North Brabant, in the
latter two from wild plants.[1173] Caraways are frequently shipped from
the ports of Morocco; the quantity exported thence in 1872 was 952 cwt.
and 288 cwt. in 1875.[1174]

The import of caraways into the United Kingdom in 1870 amounted to
19,160 cwt., almost all being from Holland.

The essential oil is manufactured on a large scale. According to
a statement of the Chamber of Commerce of Leipzig,[1175] four
establishments of that district produced in 1872 no less a quantity
than 30,955 kilo. (68,277 lb.), valued at £24,000.

=Uses=—Caraway in the form of essential oil or distilled water is used
in medicine as an aromatic stimulant, or as a flavouring ingredient.
But the consumption in Europe is far more important as a spice, in
bread, cakes, cheese, pastry, confectionary, sauces, etc., or in the
form of oil as an ingredient of alcoholic liquors. The oil is also used
for the scenting of soap.

[1172] _Pharm. Journ._ vii. (1876) 75.

[1173] Oudemans, _Aanteekeningen_, etc., Rotterdam, 1854-1856. 351.

[1174] _Consular Reports_, 1873 and 1876.

[1175] _Pharmaceutische Zeitung_, 15th April 1874.


FRUCTUS FŒNICULI.

_Fennel Fruits_, _Fennel Seeds_; F. _Fruits de Fenouil_; G. _Fenchel_.

=Botanical Origin=—_Fœniculum vulgare_ Gärtn. (_Anethum Fœniculum_
L.), an erect, branching plant with an herbaceous stem and perennial
rootstock, growing to the height of 3 or 4 feet, having leaves 3 or 3
times pinnate with narrow linear segments. In allusion to the latter
the plant had also been named _Fœniculum capillaceum_ by Gilibert.

It appears to be truly indigenous to the countries extending from the
Caspian regions (or even China?) to the Mediterranean and the Greek
Peninsula, but is a doubtful native in many parts of Central and
Southern Russia. The plant on the other hand is also found apparently
wild, over a large portion of Western Europe as far as the British
Isles, especially in the vicinity of the sea.

Fennel is largely cultivated in the central parts of Europe, as Saxony,
Franconia and Wurtemberg, also in the South of France about Nîmes, and
in Italy. It is extensively grown in India and China. The Indian plant
is an annual of somewhat low stature.[1176]

The plant varies in stature, foliage, and in the size and form of its
fruits; but all the forms belong apparently to a single species.

=History=—Fennel was used by the ancient Romans, as well for its
aromatic fruits, as for its edible succulent shoots. It was also
employed in Northern Europe at a remote period, as it is constantly
mentioned in the Anglo-Saxon medical receipts, which date as early
at least as the 11th century. The diffusion of the plant in Central
Europe was stimulated by Charlemagne, who enjoined its cultivation on
the imperial farms. Fennel shoots (_turiones fœnuculi_), fennel water,
and fennel seed, as well as anise, are all mentioned in an ancient
record[1177] of Spanish agriculture dating A.D. 961.

=Description=—The fennel fruits of commerce, commonly called _Fennel
Seeds_, are of several kinds and of very different pecuniary value. The
following are the principal sorts:—

1. _Sweet Fennel_,—known also as _Roman Fennel_, is cultivated in the
neighbourhood of Nîmes in the south of France. The plant is a tall
perennial with large umbels of 25 to 30 rays.[1178] As the plants grow
old, the fruits of each succeeding season gradually change in shape
and diminish in size, till at the end of 4 or 5 years they are hardly
to be distinguished from those of the wild fennel growing in the same
district. This curious fact, remarked by Tabernæmontanus (1588), was
experimentally proved by Guibourt.[1179]

[1176] It is an annual even in England, ripening seeds in its first
year, and then dying.

[1177] _Le Calendrier de Cordoue de l’année_, 961, publié par R. Dozy,
Leyde, 1873.

[1178] The Nîmes fennel has been usually referred to _Fœniculum dulce_
DC., but that plant has the stem compressed at the base, and only 6 to
8 rays in the umbel; and is the fennel which is eaten as a vegetable or
as a salad.

[1179] _Hist. des Drogues_, iii. (1869) 233.

The fruits of Sweet Fennel as found in the shops are oblong,
cylindrical, about ⁴/₁₀ of an inch in length by ⅒ in diameter, more or
less arched, terminating with the two-pointed base of the style, and
smooth on the surface. Each pericarp is marked by 5 prominent ridges,
the lateral being thicker than the dorsal. Between the ridges lie
vittæ, and there are two vittæ on the commissural surface,—all filled
with dark oily matter. The fruits seen in bulk have a pale greenish
hue; their odour is aromatic, and they have a pleasant, saccharine,
spicy taste.

2. _German Fennel_, _Saxon Fennel_, produced especially near
Weissenfels in the Prussian province of Saxony; the fruits are ²/₁₀
to ¼ of an inch long, ovoid-oblong, a little compressed laterally,
slightly curved, terminating in a short conical stylopodium; they are
glabrous, of a deep brown, each mericarp marked with 5 conspicuous pale
ridges, of which the lateral are the largest. Seen in bulk, the fruits
have a greenish brown hue; they have an aromatic saccharine taste, with
the peculiar smell of fennel.

3. _Wild or Bitter Fennel_ (_Fenouil amer_), collected in the south of
France, where the plant grows without cultivation. They are smaller
and broader than those of the German Fennel, being from ⅕ to ⅙ of an
inch long by about ¹/₁₅ of an inch wide. They have less prominent
ridges and at maturity are a little scurfy in the furrows and on the
commissure. Their taste is bitterish, spicy, and strongly fennel-like.
The essential oil (_Essence de Fenouil amer_) is distilled from the
entire herb.

4. _Indian Fennel._—A sample in our possession from Bombay resembles
Sweet Fennel, but the fruits are not so long, and are usually straight.
The mother plant of this drug is _F. Panmorium_ DC., now regarded as a
simple variety of _F. vulgare_ Gärtn.

=Microscopic Structure=—The most marked peculiarity of fennel is
exhibited by the vittæ, which are surrounded by a brown tissue. The
latter is made up of cells resembling the usual form of cork-cells. In
Sweet Fennel the vittæ are smaller than in the German fruit; in the
transverse section of the latter, the largest diameter of these ducts
is about 200 mkm.

=Chemical Composition=—The most important constituent of fennel fruits
is the volatile oil, which is afforded both by the Sweet and the German
fennel to the extent of about 3½ per cent.

Oil of fennel, from whatever variety of the drug obtained, consists of
_Anethol_ (or Anise-camphor)

         {OCH₃
    C₆H₄ {           ,
         {CH·CH·CH₃

and variable but less considerable proportions of an oil, isomeric with
oil of turpentine. Anethol is obtainable from fennel in two forms, the
solid and the liquid; crystals of the former are deposited when the
oil is subjected to a somewhat low temperature; the liquid anethol may
be got by collecting the portion of the crude oil passing over at 225°
C. The crystals of anethol fuse between 16 and 20°; the liquid form of
anethol remains fluid even at -10° C. By long keeping, the crystals
slowly become liquid and lose their power of reassuming a crystalline
form.

Three varieties of oil of fennel are found in commerce, namely the oils
of _Sweet Fennel_ and _Bitter Fennel_ offered by the drug-houses of
the south of France; their money value is as 3 to 1, the oil of sweet
fennel, which has a decidedly _sweet_ taste, being by far the most
esteemed. The third variety is obtained from Saxon fennel, especially
by the manufacturers of Dresden and Leipzig.[1180] We have been
supplied with type-specimens of the first two oils by the distillers,
Messrs. J. Sagnier, fils, & Cie., Nîmes; a specimen of the third has
been distilled in the laboratory of one of ourselves.

Oil of fennel differs from that of anise by displaying a considerable
rotatory power. We found the above-mentioned specimens, examined in a
column 50 mm. long, to deviate the ray of polarized light to the right
thus:—

    Oil of Sweet Fennel   29°·8
      ”    Bitter  ”       4°·8
      ”    German  ”       9°·1

The rotatory power is due to the hydrocarbon contained in the oil; we
ascertain that anethol from oil of anise is devoid of it.

Fennel fruits contain sugar, yet their sweetness or bitterness depends
on the essential oil rather than on the presence of that body. The
albumen of the seed contains fixed oil, which amounts to about 12 per
cent. of the fruit.

=Uses=—Fennel fruits are used in medicine in the form of distilled
water and volatile oil, but to no considerable extent. The chief
consumption is in cattle medicines, and of the oil in the manufacture
of cordials.


FRUCTUS ANISI.

_Anise_, _Aniseed_; F. _Fruits d’Anis vert_; G. _Anis_.

=Botanical Origin=—_Pimpinella Anisum_ L., an annual plant, is
indigenous to Asia Minor, the Greek Islands and Egypt, but nowhere to
be met with undoubtedly growing wild. It is now also cultivated in many
parts of Europe where the summer is hot enough for ripening its fruits,
as well as in India and South America. It is not grown in Britain.

=History=—Anise, which the ancients obtained chiefly from Crete
and Egypt, is among the oldest of medicines and spices.[1181] It
is mentioned by Theophrastus, by the later writers Dioscorides and
Pliny, as well as by Edrisi,[1182] who enumerates anise “sorte de
graine douce” among the products of Tunisia. In Europe we find that
Charlemagne (A.D. 812) commanded that anise should be cultivated on the
imperial farms in Germany. The Anglo-Saxon writings contain frequent
allusions to the use of dill and cumin, but we have failed to find in
them any reference to anise, nor in the _Meddygon Myddfai_.

The Patent of Pontage granted by Edward I. in 1305 to raise funds for
repairing the Bridge of London,[1183] enumerates _Anise_ (_anisium_)
among the commodities liable to toll. There are entries for it under
the name of _Annis vert_ in the account of the expenses of John, king
of France, during his abode in England, 1359-60;[1184] and it is one of
the spices of which the Grocers’ Company of London had the weighing and
oversight from 1453.[1185] By the _Wardrobe Accounts_ of Edward IV.,
A.D. 1480,[1186] it appears that the royal linen was perfumed by means
of “lytill bagges of fustian stuffed with ireos and _anneys_.”

[1180] The Leipzig Chamber of Commerce reports the quantity made by
four establishments in 1872, as 4350 kilo. (9594 lb.).

[1181] On the _Anise_ of the Bible, see note in our article Fructus
Anethi.

[1182] Page 150 of the “_Description_,” etc., quoted in the article
Fructus Carui, p. 305, note 5.

[1183] (Thomson, R.), _Chronicles of London Bridge_, 1827. 156.

[1184] Doüet d’Arcq, _Comptes de l’Argenterie des Rois de France_,
1851. 206. 220.

[1185] Herbert, _Hist. of the twelve Great Livery Companies of London_,
1834, 310.

[1186] Edited by N. H. Nicolas, Lond. 1830. 131.

Anise seems to have been grown in England as a potherb prior to 1542,
for Boorde in his _Dyetary of Helth_, printed in that year,[1187] says
of it and fennel,—“these herbes be seldom vsed, but theyr seedes be
greatly occupyde.”

In common with all other foreign commodities, anise was enormously
taxed during the reign of Charles I., the duties levied upon it
amounting to 75_s._ per 112 lb.[1188]

=Description=—Anise fruits, which have the usual characters of the
order, are about ²/₁₀ of an inch in length, mostly undivided and
attached to a slender pedicel. They are of ovoid form, tapering towards
the summit, which is crowned by a pair of short styles rising from a
thick stylopode; they are nearly cylindrical, but a little constricted
towards the commissure. Each fruit is marked by 10 light-coloured
ridges which give it a prismatic form; these as well as the rest of
the surface of the fruit, are clothed with short rough hairs. The drug
has a greyish brown hue, a spicy saccharine taste, and an agreeable
aromatic smell.

=Microscopic Structure=—The most striking peculiarity of anise fruit
is the large number of oil-ducts or vittæ it contains; each half of
the fruit exhibits in transverse section nearly 30 oil-ducts, of which
the 4 to 6 in the commissure are by far the largest. The hairs display
a simple structure, inasmuch as they are the elongated cells of the
epidermis a little rounded at the end.

=Chemical Composition=—The only important constituent of anise is the
essential oil (_Oleum Anisi_), which the fruits afford to the extent
of 3 per cent. from the best Moravian sort; Russian anise yields from
2·5 to 2·7 per cent., the German 2·3 per cent.[1189] This oil is a
colourless liquid, having an agreeable odour of anise and a sweetish
aromatic taste; its sp. gr. varies from 0·977 to 0·983. At 10° to 15°
C., it solidifies to a hard crystalline mass, which does not resume its
fluidity till the temperature rises to about 17° C.

Oil of anise resembles the oils of fennel, star-anise, and tarragon,
in that it consists almost wholly of _Anethol_ or _Anise-camphor_
described in the previous article (p. 309). This fact explains the
rotatory power of oil of anise being inferior to that of fennel. Oil
of German anise, distilled by one of us, examined under the conditions
stated, page 310, deviated only 1°·7, but to the left. _Franck_ (1868)
found oil of Saxon anise deviating 1°·1 to the right.

=Production and Commerce=—Anise is produced in Malta, about Alicante in
Spain, in Touraine and Guienne in France, in Puglia (Southern Italy),
in several parts of Northern and Central Germany, Bohemia and Moravia.
The Russian provinces of Orel, Tula and Woronesh, south of Moscow, also
produce excellent anise, and in Southern Russia, Charkow is likewise
known for the production of this drug. In Greece, anise is largely
cultivated under the name of γλυάισον, and it is much grown in Northern
India. Considerable quantities are also now imported from Chili. The
drug is, on the whole, always of a remarkably uniform appearance.

[1187] Reprinted for the Early English Text Society, 1870. 281.

[1188] _Rates of Marchandizes_, 1635.

[1189] Laboratory notes obligingly furnished by Messrs. Schimmel & Co.,
Leipzig. (1878).

=Uses=—Anise is an aromatic stimulant and carminative, usually
administered in the form of essential oil as an adjunct to other
medicines. It is also used as a cattle medicine. The essential oil is
largely consumed in the manufacture of cordials, chiefly in France,
Spain, Italy, and South America.

=Adulteration=—The fruits of anise are sometimes mixed with those of
hemlock, but whether by design or by carelessness we know not. Careful
inspection with a lens will reveal this dangerous adulteration. We have
known _powdered_ anise also to contain hemlock, and have detected it
by trituration in a mortar with a few drops of solution of potash, a
sample of pure anise for comparison being tried at the same time.

The essential oil of aniseed may readily be confounded with that of
Star-anise, which is distilled from the fruits of the widely different
_Illicium anisatum_. As stated at p. 22, these oils agree so closely
in their chemical and optical properties, that no scientific means are
known for distinguishing them.


RADIX SUMBUL.

_Sumbul Root_; F. _Racine de Sumbul_, _Sambola ou Sambula_; G.
_Moschuswurzel_.

=Botanical Origin=—_Ferula Sumbul_ Hooker fil. (_Euryangium Sumbul_
Kauffmann[1190]), a tall perennial plant discovered in 1869 by a
Russian traveller, Fedschenko, in the mountains of Maghian near
Pianjakent, in the northern part of the Khanat of Bukhara, nearly 40°
N. lat., and 68° to 69° E. long. From Wittmann’s statements (1876) it
would appear that the Sumbul plant abounds far east from that country,
in the coast province of the Amoor. A living plant transmitted from the
former district to the Botanical Garden of Moscow flowered there in
1871, another in 1875 at Kew, where the plant died after flowering.

[1190] _Nouv. Mém. de la Soc. imp. des Nat. de Moscou_, xii. (1871)
253. tabb. 24. 25.—Also figured in Bentley and Trimen, _Med. Plants_,
part 20 (1877).

=History=—The word _sumbul_, which is Arabic and signifies _an ear_
or _spike_, is used as the designation of various substances, but
especially of _Indian Nard_, the rhizome of _Nardostachys Jatamansi_
DC. Under what circumstances, or at what period, it came to be applied
to the drug under notice, we know not. Nor are we better informed as to
the history of sumbul root, which we have been unable to trace by means
of any of the works at our disposal. All we can say is, that the drug
was first introduced into Russia about the year 1835 as a substitute
for musk, that it was then recommended as a remedy for cholera, and
that it began to be known in Germany in 1840, and ten years afterwards
in England. It was admitted into the _British Pharmacopœia_ in 1867.

=Description=—The root as found in commerce consists of transverse
slices, 1 to 2 inches, rarely as much as 5 inches in diameter, and
an inch or more in thickness; the bristly crown, and tapering lower
portions, often no thicker than a quill, are also met with. The outside
is covered by a dark papery bark; the inner surface of the slices is of
a dirty brown, marbled with white, showing when viewed with a lens an
abundant resinous exudation, especially towards the circumference. The
interior is a spongy, fibrous, farinaceous-looking substance, having a
pleasant musky odour and a bitter aromatic taste.

=Microscopic Structure=—The interior tissue of sumbul root is very
irregularly constructed of woody and medullary rays, while the cortical
part exhibits a loose spongy parenchyme. The structural peculiarity of
the root becomes obvious, if thin slices are moistened with solution
of iodine, when the medullary rays assume by reason of the starch they
contain an intense blue. The structure of the root differs from the
usual arrangement by the formation of independent secondary cambial
zones with fibro-vascular bundles within the original cambium. Similar
peculiarities are also displayed by the roots of Myrrhis odorata,
Convolvulus Scammonia, Ipomœa Turpethum and others.[1191] Large
balsam-ducts are also observable in Sumbul as well as in the roots of
many other Umbelliferæ.[1192]

=Chemical Composition=—Sumbul root yields about 9 per cent. of a soft
balsamic resin soluble in ether, and ⅓ per cent. of a dingy bluish
essential oil. The resin has a musky smell, not fully developed until
after contact with water. According to Reinsch (1848), it dissolves in
strong sulphuric acid with a fine blue colour, but in our experience
with a crimson brown. The same chemist states that when subjected to
dry distillation, it yields a blue oil.

Solution of potash is stated to convert the resin of sumbul into a
crystalline potassium salt of _Sumbulamic Acid_, which latter was
obtained in a crystalline state by Reinsch in 1843, but has not been
further examined. Sumbulamic acid, which smells strongly of musk,
appears to be a different substance from _Sumbulic_ or _Sumbulolic
Acid_, the potassium salt of which may be extracted by water from the
above-mentioned alkaline solution. Ricker and Reinsch (1848), assert
that the last-mentioned acid, of which the root contains about ¾ per
cent., is none other than _Angelic Acid_, accompanied, as in angelica
root, by a little valerianic acid. All these substances require
further investigation, as well as the body called _Sumbulin_, which
was prepared by Murawjeff (1853), and is said to form with acids,
crystalline salts.

Sommer has shown (1859) that by dry distillation, sumbul resin
yields _Umbelliferone_, which substance we shall further notice when
describing the constituents of galbanum.

=Uses=—Prescribed in the form of tincture as a stimulating tonic.

[1191] See A. de Bary, _Anatomie_, 1877. 623.

[1192] The structure and growth of Sumbul root have been elaborately
studied by Tchistiakoff, of whose observations, first published in
Russian in 1870, an Italian translation with two plates has appeared in
the _Nuovo Giornale Botanico_ for Oct. 1873. 298.

=Adulteration=—_Bombay Sumbul_, or “_Boi_,” is the root of Dorema
Ammoniacum (see article Ammoniacum, p. 324), which is largely
imported into Bombay, being used there in the Parsee fire temples as
an incense.[1193] The largest roots, for which we are indebted to
Professor Dymock, are three inches in diameter at the crown, by 8
inches in length. They are easily distinguished from the Sumbul by
their decidedly yellowish hue as well as by the absence of any musky
odour. We extracted by alcohol, from the root dried at 100° C., 26 per
cent. of a resin identical with that afforded by commercial Ammoniacum.

Bombay Sumbul agrees with the _Indian Sumbul_ as described by
Pereira.[1194]


ASAFŒTIDA.

_Gummi-resina Asafœtida vel Assafœtida_; _Asafœtida_; F. _Asafœtida_;
G. _Asant_, _Stinkasant_.

=Botanical Origin=—Two perennial umbelliferous plants are now generally
cited as the source of this drug; but though they are both capable
of affording a gum-resin of strong alliaceous odour, it has not been
proved that either of them furnishes the asafœtida of commerce. The
plants in question are:—

1. _Ferula Narthex_ Boiss. (_Narthex Asafœtida_ Falconer), a gigantic
herbaceous plant, having a large root several inches in thickness, the
crown of which is clothed with coarse bristly fibres; it has an erect
stem attaining 10 feet in height, throwing out from near its base
upwards a regular series of branches bearing compound umbels, each
branch proceeding from the axil of a large sheathing inflated petiole,
the upper of which are destitute of lamina. The radical leaves, 1½ feet
long, are bipinnate with broadly ligulate obtuse lobes. It has a large
flat fruit with winged margin. When wounded, the plant exudes a milky
juice having a powerful smell of asafœtida. It commences to grow in
early spring, rapidly throwing up its foliage, which dies away at the
beginning of summer. It does not flower till the root has acquired a
considerable size and is several years old.

_F. Narthex_, which now exists in several botanic gardens and has
flowered twice in that of Edinburgh, was discovered by Falconer in
1838, in the valley of Astor or Hasora (35° N. lat., 74°·30 E. long.
north of Kashmir).[1195]

2. _Ferula Scorodosma_ Bentham et Hooker (_Scorodosma fœtidum_ Bunge;
_Ferula Assa fœtida_ L. in Boissier, Flora orientalis ii. 994)—In form
of leaf, in the bristly summit of the root, and in general aspect, this
plant resembles the preceding; but it has the stem (5 to 7 feet high)
nearly naked, with the umbels, which are very numerous, collected at
the summit; and the few stem-leaves have not the voluminous sheathing
petioles that are so striking a feature in _Narthex_. In _Narthex_,
the vittæ of the fruit are conspicuous,—in _Scorodosma_ almost
obsolete; but the development of these organs in feruloid plants varies
considerably, and has been rejected by Bentham and Hooker as affording
no important distinctive character. _Scorodosma_ is apparently more
pubescent than _Narthex_.

[1193] _Pharm. Journ._ vi. (1875) 321.

[1194] Elements of _Mat. Med._ ii. p. 2 (1857) 208; also Bentley,
_Pharm. Journ._ ix. (1878) 479.

[1195] We refrain from citing localities in Tibet, Beluchistan and
Persia, where plants supposed to agree with that of Falconer have been
found by other collectors.

_F. Scorodosma_ was discovered by Lehmann in 1841, in the sandy deserts
eastwards of the Sea of Aral, and also on the hills of the Karatagh
range south of the river Zarafshan,—that is to say, south-east of
Samarkand. In 1858-59, it was observed by Bunge about Herat. At nearly
the same period, it was afresh collected between the Caspian and Sea of
Aral, and in the country lying eastward of the latter, by Borszczow,
a Russian botanist, who has made it the subject of an elaborate and
valuable memoir.[1196]

The most detailed account of the asafœtida plant we possess is that
of the German traveller Engelbert Kämpfer, who in 1687 observed it in
the Persian province of Laristan, between the river Shúr and the town
of Kongún, also in the neighbourhood of the town of Dusgan or Disgun,
in which latter locality[1197] alone he saw the gum-resin collected.
He states that he found the plant also growing near Herat. Kämpfer has
given figures of his plant which he calls _Asa fœtida Disgunensis_, and
his specimens consisting of remnants of leaves, a couple of mericarps
(in a bad state) and a piece of the stem a few inches long, are still
preserved in the British Museum.

These materials have been the subject of much study, in order to
determine which of the asafœtida plants of modern botanists should be
identified with that of Kämpfer. Falconer and Borszczow have arrived
in turns at the conclusion that his own plant accords with Kämpfer’s.
But Kämpfer’s figures agree well neither with _Narthex_ nor with
_Scorodosma_. The plant they represent does not form, it would seem,
the branching pyramid of the _Narthex_ (as it flowered at Edinburgh),
nor has it the multitude of umbels seen in Borszczow’s figure of
_Scorodosma_.[1198]

Whether Kämpfer’s plant is really identical with either of those we
have noticed, and whether the discrepancies observable are due to
careless drawing, or to actual difference, are points that cannot be
settled without the examination of more ample specimens.

Great allowance must be made for the period of growth at which these
plants have been observed. Kämpfer saw his plant when quite mature, and
not when its stem was young and flowering. _Narthex_ is scarcely known
except from specimens grown at Edinburgh, those obtained by Falconer
in Tibet having been gathered when dry and withered. Even Borszczow’s
plant appears never to have been seen by any botanist while its
flower-stem was in a growing state.

History—Whether the substance which the ancients called _Laser_ was
the same as the modern _Asafœtida_ is a question that has been often
discussed during the last three hundred years, and it is one upon which
we shall attempt to offer no further evidence. Suffice it to say that
_Laser_ is mentioned along with products of India and Persia, among
the articles on which duty was levied at the Roman custom-house of
Alexandria in the 2nd century.

“_Hingu_,” doubtless meaning Asafœtida, occurs in many Sanskrit works,
especially in epic poetry, but also in Susruta.

[1196] _Die Pharmaceutisch-wichtigen Ferulaceen der Aralo-Caspischen
Wüste_, St. Petersb. 1860, pp. 40, eight plates.—In the _Medicinal
plants_ of Bentley and Trimen, Narthex is figured in part 29 and
Scorodosma in part 24.

[1197] Which we cannot find on any map.

[1198] Kämpfer figures his plant with about 6 umbels on a stalk, while
_Scorodosma_, as represented by Borszczow, has at least 25.

Asafœtida was certainly known to the Arabian and Persian geographers
and travellers of the middle ages. One of these, Ali Istakhri, a native
of Istakir, the ancient Persepolis, who lived in the 10th century,
states[1199] that it produced abundantly in the desert between Sistan
and Makran, and is much used by the people as a condiment. The region
in question comprises a portion of Beluchistan.

The geographer Edrisi,[1200] who wrote about the middle of the 12th
century, asserts that asafœtida, called in Arabic _Hiltit_, is
collected largely in a district of Afghanistan near Kaleh Bust, at the
junction of the Helmand with the Arghundab, a locality still producing
the drug. Other Arabian writers as quoted by Ibn Baytar,[1201] describe
asafœtida in terms which show it to have been well known and much
valued.

Matthæus Platearius, who flourished in the second half of the 12th
century, mentions asafœtida in his work on simple medicines, known as
_Circa instans_, which was held in great esteem during the middle ages.
It is also named a little later by Otho of Cremona,[1202] who remarks
that the more fœtid the drug, the better its quality. Like other
productions of the East, asafœtida found its way in European commerce
during the middle ages through the trading cities of Italy. It is
worthy of remark that it is much less frequently mentioned by the older
writers than galbanum, sagapenum and opopanax. In the 13th century, the
“Physicians of Myddfai” in Wales,[1203] considered asafœtida as one of
the substances which every physician “ought to know and use.”

=Collection=—The collecting of asafœtida on the mountains about Dusgun
in Laristan in Persia, as described by Kämpfer,[1204] is performed
thus:—

The peasants repair to the localities where the plants abound, about
the middle of April, at which time the latter have ceased growing, and
their leaves begin to show signs of withering. The soil surrounding the
plant is removed to the depth of a span, so as to bare a portion of the
root. The leaves are then pulled off, the soil is replaced, and over
it are laid the leaves and other herbage, with a stone to keep them in
place, the whole being arranged in this way to prevent injury to the
root by the heat of the sun.

[1199] _Buch der Länder_, translated by Mordtmann, Hamburg, 1845. 111.

[1200] _Géographie d’Edrisi_, traduite par Jaubert, i. (1836) 450.

[1201] Sontheimer’s transl. i. (1840) 84.

[1202] Choulant, _Macer Floridus_, Lips. 1832. 159.

[1203] _Meddygon Myddfai._ 282. 457 (see bibliographical notices at the
end).

[1204] _Amœnitates Exoticæ_, Lemgoviæ, 1712. 535-552.

About forty days later, that is towards the end of May, the people
return, the men being armed with knives for cutting the root, and broad
iron spatulas for collecting the exuded juice. Having first removed
the leaves and earth, a thinnish slice is taken from the fibrous crown
of the root, and two days later the juice is scraped from the flat cut
surface. The root is again sheltered, care being taken that nothing
rests on it. This operation is repeated twice in the course of the next
few days, a very thin slice being removed from the root after each
scraping. The product got during the first cutting is called _shīr_,
i.e. _milk_, and is thinner and more milky and less esteemed than
that obtained afterwards. It is not sold in its natural state, but is
mixed with soft earth (_terra limosa_) which is added to the extent of
an equal, or even double, weight of the gum-resin, according to the
softness of the latter.

After the last cutting, the roots are allowed to rest 8 or 10 days,
when a thicker exudation called _pispaz_, more esteemed than the first,
is obtained by a similar process carried on at intervals during June
and July, or even later, until the root is quite exhausted.

The only recent account of the production of asafœtida that we have
met with, is that of Staff-surgeon H. W. Bellew, who witnessed the
collection of the drug in 1857 in the neighbourhood of Kandahar.[1205]
The frail withered stem of the previous year with the cluster of
newly-sprouted leaves, is cut away from the top of the root, around
which a trench of 6 inches wide and as many deep, is dug in the earth.
Several deep incisions are now made in the upper part of the root, and
this operation is repeated every 3 or 4 days as the sap continues to
exude, which goes on for a week or two according to the strength of the
plant. The juice collects in tears about the top of the root, or when
very abundant flows into the hollow around it. In all cases as soon as
incisions are made, the root is covered with a bundle of loose twigs
or herbs, or even with a heap of stones, to protect it from the drying
effects of the sun. The quantity of gum-resin obtained is variable;
some roots yield scarcely half an ounce, others as much as two pounds.
Some of the roots are no larger than a carrot, others attain the
thickness of a man’s leg. The drug is said to be mostly adulterated
before it leaves the country, by admixture of powdered gypsum or flour.
The finest sort, which is generally sold pure, is obtained solely “from
the node or leaf-bud in the centre of the root-head.” At Kandahar, the
price of this superior drug is equivalent to from 2_s._ 8_d._ to 4_s._
8_d._ per lb, while the ordinary sort is worth but from 1_s._ to 2_s._

During a journey from North-western India to Teheran in Persia, through
Beluchistan and Afghanistan, performed in the spring of 1872, the
same traveller observed the asafœtida plant in great abundance on
many of the elevated undulating pasture-covered plains and hills of
Afghanistan, and of the Persian province of Khorassan. He states that
the plant is of two kinds, the one called _Kamá-i-gawí_ which is grazed
by cattle and used as a potherb, and the other known as _Kamá-i-angúza_
which affords the gum-resin of commerce. The collecting of this last
is almost exclusively in the hands of the western people of the Kákarr
tribe, one of the most numerous and powerful of the Afghan clans, who,
when thus occupied, spread their camps over the plains of Kandahar to
the confines of Herat.[1206]

Wood, in his journey to the source of the Oxus, found asafœtida to
be largely produced in a district to the north of this, namely the
mountains around Saigan or Sykan (lat. 35° 10, long. 67° 40), where,
says he, the land affording the plant is as regularly apportioned out
and as carefully guarded as the cornfields on the plain.[1207]

[1205] _Journal of a Mission to Afghanistan_, Lond. 1862. 270.

[1206] Bellew, _From the Indus to the Tigris_, London. 1874. 101. 102.
286. 321. &c.

[1207] Wood, _Journey to the Source of the River Oxus_, new ed. 1872,
131.

=Description=—The best asafœtida is that consisting chiefly of slightly
or not agglutinated tears. This is the _Kandahari-Hing_ of the Bombay
market, which is not always to be met with in Bombay, and even there
is only used by wealthy people as a condiment. It is not exported to
Europe. The best sort shipped to Europe is the _Anguzeh-i-Lari_, coming
from Laristan by way of Afghanistan and the Bolan Pass to Bombay. It
shows agglutinated tears, or when freshly imported, it forms a clammy
yet hard yellowish-grey mass, in which opaque, white or yellowish milky
tears, sometimes an inch or two long, are more or less abundant.

Sometimes asafœtida is imported as a fluid honey-like mass, apparently
pure. We presume that such is that of the first gathering, which
Kämpfer says is called _milk_. The drug is often adulterated with
earthy matter which renders it very ponderous; it must be granted that
an addition of such matters may often be necessary in order to enable
the drug to be transported. This earthy or stony asafœtida constitutes
at Bombay a distinct article of commerce under the name of _Hingra_.

By exposure to air, asafœtida acquires a bright pink and then a brown
hue. The perfectly pure tears display when fractured a conchoidal
surface, which changes from milky white to purplish pink in the course
of some hours. If a tear is touched with nitric acid sp. gr. 1·2, it
assumes for a short time a fine green colour.

When asafœtida is rubbed in a mortar with oil of vitriol, then diluted
with water and neutralized, the slightly coloured solution exhibits
a bluish fluorescence. The same will be observed, to some extent, if
tears of the drug are immersed in water and a little ammonia is added.
The tears of asafœtida when warmed become adhesive, but by cold are
rendered so brittle that they may be powdered. With water they easily
form a white emulsion.

The drug has a powerful and persistent alliaceous odour and a bitter
acrid alliaceous taste.

=Chemical Composition=—Asafœtida consists of resin, gum and essential
oil, in varying proportions, but the resin generally amounting to more
than one-half.

As to the oil, we have repeatedly obtained from 6 to 9 per cent. by
distilling it from common copper stills. It is light yellow, has a
repulsive, very pungent odour of asafœtida, tastes at first mild, then
irritating, but does not stimulate like oil of mustard when applied to
the skin. It is neutral, but after exposure to the air acquires an acid
reaction and different odour; it evolves sulphuretted hydrogen. In the
fresh state, the oil is free from oxygen; it begins to boil at 135° to
140° C., but with continued evolution of hydrogen sulphide, so that we
did not succeed in preparing it of constant composition, the amount of
sulphur varying from 20 to 25 per cent. We found it to have a sp. gr.
of 0·951 at 25°, and a strong dextrogyrate power. If one drop of it is
allowed to float on water it assumes a fine violet hue by vapours of
bromine.

The essential oil of asafœtida submitted to fractional distillation
yielded us, at 300°, a considerable proportion of a most _beautifully
blue coloured_ oil. By very cautiously oxidizing the crude oil, we
obtained a small amount of extremely deliquescent crystals of a
sulphonic acid. Sodium or potassium decomposes the oil with evolution
of gas, forming potassium sulphide; the residual oil is found to have
the odour of cinnamon.

The resin of asafœtida is not wholly soluble in ether or in chloroform,
but dissolves with decomposition in warm concentrated nitric acid. It
contains a little _Ferulaic Acid_,

    C₆H₃(OCH₃)CH·CH·COOH,
        (OH )

discovered by Hlasiwetz and Barth in 1866, crystallizing in iridescent
needles soluble in boiling water; it is homologous with _Eugetic Acid_,

    C₆H₂(OCH₃)COOH,
        (OH )CH·CH·CH₃,

which is to be obtained by adding CO₂ to the molecule of eugenol (page
284).

Ferulaic acid may be obtained from vanillin,

         {OCH₃
    C₆H₃ {OH          (see article Vanilla).
         {CHO

Fused with potash, ferulaic acid yields oxalic and carbonic acids,
several acids of the fatty series, and protocatechuic acid. The resin
itself treated in like manner after it has been previously freed from
gum, yields resorcin; and by dry distillation, oils of a green, blue,
violet or red tint, besides about ¼ per cent. of _Umbelliferone_,
C₉H₆O₃.

The mucilaginous matter of asafœtida consists of a smaller part soluble
in water and an insoluble portion. The former yields a neutral solution
which is not precipitated by neutral acetate of lead. The insoluble
part is readily dissolved by caustic lye and again separates on
addition of acids.

=Commerce=—The drug is at the present day produced exclusively in
Afghanistan. Much of it is shipped in the Persian Gulf for Bombay,
whence it is conveyed to Europe; it is also brought into India by way
of Peshawur, and by the Bolan pass in Beluchistan.

In the year 1872-73, there were imported into Bombay by sea, chiefly
from the Persian Gulf, 3367 cwt. of asafœtida, and 4780 cwt. of the
impure form of the drug called _Hingra_. The value of the latter is
scarcely a fifth that of the genuine kind. The export of asafœtida from
Bombay to Europe is very small in comparison with the shipments to
other ports of India.

=Uses=—Asafœtida is reputed stimulant and antispasmodic. It is in great
demand on the Continent, but is little employed in Great Britain. Among
the Mahommedan as well as Hindu population of India, it is generally
used as a condiment, and is eaten especially with the various pulses
known as _dāl_. In regions where the plant grows, the fresh leaves are
cooked as an article of diet.

=Adulteration=—The systematic adulteration, chiefly with earthy matter
already pointed out, may be estimated by exhausting the drug with
alcohol and incinerating the residue.

Allied Substances.

_Hing from Abushahir_, also in Bombay simply called _Hing_.

Among the natives of Bombay, a peculiar form of asafœtida is in
use that commands a much higher price than those just described;
it is also the only kind admitted there in the government sanitary
establishmente. This is the _Abushaheree Hing_, imported from Abushir
(Bender Bushehr) and Bender Abassi on the Persian Gulf. It is the
product of _Ferula alliacea_ Boiss.[1208] (_F. Asafœtida_ Boiss. et
Buhse, non Linn.) discovered in 1850 by Buhse, and observed in 1858-59
by Bunge in many places in Persia. This Hing is collected near Yezd in
Khorassan, and also in the province of Kerman, the plant being known as
_angúza_, the same name that is applied to _Scorodosma_.

Abushaheree Hing is never brought into European trade.[1209] It
forms an almost blackish brown, originally _translucent_, brittle
mass, of extremely fœtid alliaceous odour, containing many pieces of
the stem with no admixture of earth. Guibourt, by whom it was first
noticed,[1210] was convinced that it had not been obtained from the
root, but had been _cut from the stem_. He remarks that Theophrastus
alludes to asafœtida (as he terms the _Silphium_[1211] of this author)
as being of two kinds,—the one of the stem, the other of the root; and
thinks the former may be the sort under notice. Vigier,[1212] who calls
it _Asafœtida nauséeux_, found it to contain in 100 parts, of resin and
essential oil 37·5, and gum 23·7.

We find the odour of the Hing much more repulsive than that of common
Asafœtida. The former yields an abundance of essential oil, which
differs by its reddish hue from that of asafœtida. The oil of Hing,
as distilled by one of us (1877) has also a higher specific gravity,
namely, 1·02 at 25° C. We find also its rotatory power stronger;
it deviated 38°·8 to the right, when examined in a column of 100
millimetres in length. The oil of common asafœtida deviated 13°·5 under
the same conditions.

By gently warming the Abushaheree Hing with concentrated hydrochloric
acid, about 1·12 sp. gr., it displays simply a dingy brown hue. By
shaking it with water and a little ammonia no fluorescence is produced.
In all these respects there is consequently a well-marked difference
between the drug under examination and common asafœtida.

_F. teterrima_ Kar. et Kir., a plant of Soungaria, is likewise
remarkable for its intense alliaceous smell; but the plant is not known
as the source of any commercial product.[1213]


GALBANUM.

_Gummi-resina Galbanum_; _Galbanum_; F. _Galbanum_; G. _Mutterharz_.

=Botanical Origin=—The uncertainty that exist as to the plants which
furnish asafœtida, hangs over those which produce the nearly allied
drug _Galbanum_. Judging from the characters of the latter, it can
scarcely be doubted that it is yielded by umbelliferous plants of at
least two species, which are probably the following:[1214]—

[1208] _Flora Orientalis_, ii. (1872) 995.

[1209] A large specimen of it was kindly presented to one of us (H.)
by Mr. D. S. Kemp of Bombay. We have also examined the same drug in
the Indian Museum, and further received good specimens by the kindness
of Professor Dymock. See his notes _Pharm. Journ._ v. (1875) 103, and
viii. (1877) 103.

[1210] _Hist. des Drogues_, iii. (1850) 223.

[1211] _Hist. Plantarum_, 1. vi. c. 3.

[1212] _Gommes-résines des Ombellifères_ (thèse), Paris, 1869. 32.

[1213] Borszczow, _op. cit._ 13-14.

[1214] The following in addition have at various times been supposed
to afford galbanum:—_Ferulago galbanifera_ Koch, a native of the
Mediterranean region and Southern Russia; _Opoidia galbanifera_ Lindl.,
a Persian plant of doubtful genus; _Bubon Galbanum_ L., a shrubby
umbellifer of South Africa.

1. _Ferula galbaniflua_ Boiss. et Buhse,[1215]—a plant with a tall,
solid stem, 4 to 5 feet high, greyish, tomentose leaves, and thin flat
fruits, 5 to 6 lines long, 2 to 3 broad, discovered in 1848 at the
foot of Demawend in Northern Persia, and on the slopes of the same
mountain at 4,000 to 8,000 feet, also on the mountains near Kushkäk
and Churchurä (Jajarúd?). Bunge collected the same plant at Subzawar.
Buhse says that the inhabitants of the district of Demawend collect
the gum-resin of this plant which is _Galbanum_; the tears which exude
spontaneously from the stem, especially on its lower part and about
the bases of the leaves, are at first milk-white, but become yellow
by exposure to light and air. It is not the practice, so far as he
observed, to wound the plant for the purpose of causing the juice to
exude more freely, nor is the gathering of the gum in this district
any special object of industry.[1216] The plant is called in Persian
_Khassuih_, and the Mazanderan dialect _Boridsheh_.

2. _F. rubricaulis_ Boiss.[1217] (_F. erubescens_ Boiss. ex parte,
Aucher _exsicc._ n. 4614, Kotschy n. 666).—This plant was collected
by Kotschy in gorges of the Kuh Dinar range in Southern Persia, and
probably by Aucher-Eloy on the mountain of Dalmkuh in Northern Persia.
Borszczow,[1218] who regards it as the same as the preceding (though
Boissier[1219] places it in a different section of the genus), says,
on the authority of Buhse, that it occurs locally throughout the whole
of Northern Persia, is found in plenty on the slopes of Elwund near
Hamadan, here and there on the edge of the great central salt-desert
of Persia, on the mountains near Subzawar, between Ghurian and Kháf,
west of Herat, and on the desert plateau west of Kháf. He states,
though not from personal observation, that its gum-resin, which
constitutes _Persian Galbanum_, is collected for commercial purposes
around Hamadan. _F. rubricaulis_ Boiss. has been beautifully figured by
Berg[1220] under the name of _F. erubescens_.

=History=—Galbanum, in Hebrew _Chelbenah_, was an ingredient of the
incense used in the worship of the ancient Israelites,[1221] and
is mentioned by the earliest writers on medicine as Hippocrates
and Theophrastus.[1222] Dioscorides states it to be the juice of a
_Narthex_ growing in Syria, and describes its characters, and the
method of purifying it by hot water exactly as followed in modern
times. We find it mentioned in the 2nd century among the drugs on which
duty was levied at the Roman custom-house at Alexandria.[1223] Under
the name of _Kinnah_ it was well known to the Arabians, and through
them to the physicians of the school of Salerno.

[1215] _Aufzählung der in einer Reise durch Transkaukasien und Persien
gesammelten Pflanzen._—_Nouv. Mém. de la Soc. imp. des Nat. de Moscou_,
xii. (1860) 99.—Fig. in Bentley and Trimen, _Med. Plants_, part 16.

[1216] Buhse, _l.c._; also _Bulletin de la Soc. imp. des Nat. de
Moscou_, xxiii. (1850) 548.

[1217] _Diagnoses Plantarum novarum præsertim orientalium_, ser. ii.
fasc. 2 (1856) 92.

[1218] _Op. cit._ 36 (see p. 315, note 1).

[1219] _Flora Orientalis_, ii. (1872) 995.

[1220] Berg u. Schmidt, _Offizinelle Gewächse_, iv. (1863) tab. 31 _b_.

[1221] Exodus xxx. 34.—_Jes. Sirach_ xxiv. 18.—In imitation of the
ancient Jewish custom, Galbanum is a component of the incense used in
the Irvingite chapels in London.

[1222] Χαλβάνη—Theophr. _Hist. Plant._ ix. c. 1.

[1223] Vincent, _Commerce of the Ancients_, ii. (1807) 692.

In the journal of expenses of John, king of France, during his
captivity in England, A.D. 1359-60, there is an entry for the purchase
of 1 lb. of Galbanum which cost 16_s._, 1 lb. of Sagapenum (_Serapin_)
at the same time costing only 2_s._[1224] In common with other products
of the East, these drugs used to reach England by way of Venice, and
are mentioned among the exports of that city to London in 1503.[1225]

An edict of Henry III. of France promulgated in 1581, gives the prices
per lb. of the gum-resins of the _Umbelliferæ_ as follows:—Opopanax,
32 sols, Sagapenum 22 sols, Asafœtida 15 sols, Galbanum 10 sols,
Ammoniacum 6 sols 6 deniers.[1226]

=Description=—Galbanum is met with in drops or tears, adhering _inter
se_ into a mass, usually compact and hard, but sometimes found so soft
as to be fluid. The tears are of the size of a lentil to that of a
hazel-nut, translucent, and of various shades of light brown, yellowish
or faintly greenish. The drug has a peculiar, not unpleasant, aromatic
odour, and a disagreeable, bitter, alliaceous taste.

In one variety, the tears are dull and waxy, of a light yellowish
tint when fresh, but becoming of an orange-brown by keeping; they are
but little disposed to run together, and are sometimes quite dry and
loose, with an odour that somewhat reminds one of savine. In recent
importations of this form of galbanum, we have noticed a considerable
admixture of thin transverse slices of the root of the plant, an inch
or more in diameter.

=Chemical Composition=—Galbanum contains volatile oil, resin and
mucilage. The first, of which 7 per cent. may be obtained by
distillation with water, is a colourless or slightly yellowish liquid,
partly consisting of a hydrocarbon, C₁₀H₁₆, boiling at from 170° to
180°. This oil affords easily crystals of terpin, C₁₀H₁₆ + 3OH₂, if it
is treated as mentioned in the article Oleum Cajuputi; it also affords
the crystallized compound C₁₀H₁₆ + HCl. But the prevailing part of oil
of galbanum consists of hydrocarbons of a much higher boiling point.
The crude oil has a mild aromatic taste, and deviates the ray of
polarized light to the right.

The resin, which we find to constitute about 60 per cent. of the drug,
is very soft, and dissolves in ether or in alkaline liquids, even
in milk of lime, but only partially in bisulphide of carbon. When
heated for some time at 100° C. with hydrochloric acid, it yields
_Umbelliferone_, C₉H₆O₃, which may be dissolved from the acid liquid
by means of ether or chloroform; it is obtained on evaporation in
colourless acicular crystals. Umbelliferone is soluble in hot water;
its solution exhibits, especially on addition of an alkali, a brilliant
blue fluorescence which is destroyed by an acid. If a small fragment
of galbanum is immersed in water, the fluorescence is immediately
produced by a drop of ammonia.[1227] The same phenomenon takes place
with asafœtida, not at all with ammoniacum; it is probably due to
traces of Umbelliferone pre-existing in the former drugs. By boiling
the umbelliferone with concentrated caustic lye, it splits up into
resorcin, carbonic acid and formic acid.

[1224] Doliet d’Arcq, _Comptes de l’Argenterie des Rois de France_
(1851) 236.—The prices must be multiplied by 3 to give a notion of
present value.

[1225] Pasi, _Tariffa de Pesi e Misure_, Venet. 1521. 204 (1st edition,
1503).

[1226] Fontanon, _Edicts et Ordonnances des Rois de France_, ii. (1585)
388.

[1227] This property of Umbelliferone may be beautifully shown by
dipping some bibulous paper into water which has stood for an hour or
two on lumps of galbanum, and drying it. A strip of this paper placed
in a test tube of water with a drop of ammonia, will give a superb blue
solution, instantly losing its colour on the addition of a drop of
hydrochloric acid.

Umbelliferone is also produced from many other aromatic umbelliferous
plants, as _Angelica_, _Levisticum_ and _Meum_, when their respective
resins are submitted to dry distillation. According to Zwenger (1860)
it may be likewise obtained from the resin of _Daphne Mezereum_ L. The
yield is always small; it is highest in galbanum, but even in this does
not much exceed 0·8 per cent. reckoned on the crude drug.

By submitting galbanum-resin to dry distillation, there will be
obtained a thick oil of an intense and brilliant blue,[1228] which was
noticed as early as about the year 1730 by Caspar Neumann of Berlin.
It is a liquid having an aromatic odour and a bitter acrid taste; in
cold it deposits crystals of umbelliferone, which can be extracted by
repeatedly shaking the oil with boiling water. A small amount of fatty
acids is also removed at the same time. Submitted to rectification
the crude oil at first yields a greenish portion and then the superb
blue oil. Kachler (1871) found that it could be resolved by fractional
distillation into a colourless oil having the formula C₁₀H₁₆, and a
blue oil to which he assigned the composition C₁₀H₁₆O, boiling at
289° C. As to the hydrocarbon, it boils at 240° C., and therefore
differs from the essential oil obtained when galbanum is distilled
with water. The blue oil, after due purification, agrees, according to
Kachler, with the blue oil of the flowers of _Matricaria Chamomilla_
L. Each may be transformed by means of potassium into a colourless
hydrocarbon, C₁₀H₁₆; or by anhydride of phosphoric acid into another
product, C₁₀H₁₄, likewise colourless. The latter, as well as the former
hydrocarbon, if diluted with ether, and bromine be added, assumes for a
moment a fine blue tint; the colourless oil as afforded by the drug on
distillation with water assumes also the same coloration with bromine.

[1228] We have found it best to mix the galbanum-resin with coarsely
powdered pumice-stone; the oil is then easily and abundantly obtainable.

By fusing galbanum-resin with potash, Hlasiwetz and Barth
(1864) obtained crystals (about 6 per cent.) of _Resorcin_ or
_Meta-Dioxybenzol_, together with acetic and volatile fatty acids. The
name of this remarkable substance alludes to Orcin, which had been
extracted in 1829 by Robiquet from lichens. The formula of Resorcin,
C₆H₄(OH)₂, shows at once its relations to Orcin, C₆H₃CH₃(OH)₂.
Resorcin has been ascertained to be frequently produced by melting
other resins with potash; it has also been prepared on a large scale
for the manufacture of the brilliant colouring matter called _Eosin_.
Galbanum-resin treated with nitric acid yields Trinitroresorcin
C₆H(NO₂)₃(OH)₂, the so-called _Styphnic Acid_.

If galbanum, or still better its resin, is very moderately warmed with
concentrated hydrochloric acid, a red hue is developed, which turns
violet or bluish if spirit of wine is slowly added. Asafœtida treated
in the same way assumes a dingy greenish colour, and _ammoniacum is
not altered_ at all. This test probably depends upon the formation of
resorcin, which in itself is not coloured by hydrochloric acid, but
assumes a red or blue colour if sugar or mucilage or certain other
substances are present. It is remarkable that ammoniacum, though
likewise yielding resorcin when fused with potash, assumes no red
colour when warmed with hydrochloric acid. The mucilage of galbanum has
not been minutely examined.

=Commerce=—Galbanum is, we believe, brought into commerce chiefly from
Eastern Europe. It is stated that considerable quantities reach Russia
by way of Astrachan and Orenburg.

=Uses=—Galbanum is administered internally as a stimulating
expectorant, and is occasionally applied in the form of plaster to
indolent swellings.

Allied Substances.

_Sagapenum_—This is a gum-resin which, when pure, forms a tough
softish mass of closely agglutinated tears. It differs from asafœtida
in forming brownish (not milk-white) tears, which when broken do not
acquire a pink tint; also in not having an alliaceous odour. A good
specimen presented to us by Professor Dymock of Bombay (1878) reminds
in that and other respects rather of galbanum. We find this sagapenum
to be devoid of sulphur but containing umbelliferone; it is extremely
remarkable for the intense and permanent purely blue colour it
acquires in cold when the smallest fragment of the drug is immersed in
hydrochloric acid 1·13 sp. gr.

Sagapenum, which in mediæval pharmacy was often called _Serapinum_, is
so frequently mentioned by the older writers that it must have been a
plentiful substance. At the present day it can scarcely be procured
genuine even at Bombay, whither it is sometimes brought from Persia.
The botanical origin of the drug is unknown.


AMMONIACUM.

_Gummi-resina Ammoniacum_; _Ammoniacum or Gum Ammoniacum_; F.
_Gomme-résine Ammoniaque_; G. _Ammoniak-gummiharz_.

=Botanical Origin=—Dorema Ammoniacum, Don, a perennial plant,[1229]
with a stout, erect, leafless flower-stem, 6 to 8 feet high, dividing
towards its upper part into numerous ascending branches, along
which are disposed on thick short stalks, ball-like simple umbels,
scarcely half an inch across, of very small flowers. The aspect of
the full-grown plant is therefore very unlike that of _Ferula_. The
_Dorema_ has large compound leaves with broad lobes. The whole plant
in its young state is covered with a tomentum of soft, stellate hairs,
which give it a greyish look, but which disappear as it ripens its
fruits. The withered stems long remain erect, and occurring in immense
abundance and overtopping the other vegetation of the arid desert,
having a striking appearance.[1230] The root is described in the
article on Sumbul, p. 313.

The plant occurs over a wide area of the barren regions of which Persia
is the centre. According to Bunge and Bienert, its north-western limit
appears to be Shahrud (S.E. of Asterabad), whence it extends eastwards
to the deserts south of the Sea of Aral and the Sir-Daria. The most
southern point at which the plant has been observed is Basiran, a
village of Southern Khorassan in N. lat. 32°, E. long. 59°.

[1229] Fig. in Bentley and Trimen, _Medic. Plants_, part 33 (1878).

[1230] Fraser, _Journey into Khorasān_, 1825. 118; Polak, _Persien, das
Land und seine Leute_, ii. (1865) 282.

Of the three or four other species of _Dorema_, _D. Aucheri_
Boiss.[1231] affords very good ammoniacum, as we know by an ample
specimen of the gum deposited together with the plant in the British
Museum by Mr. W. K. Loftus, who in 1751 collected both at Kirrind
in Western Persia, where the plant is called in Kurdish _Zuh_.
Boissier[1232] includes as _D. Aucheri_ another plant, called by Loftus
_D. robustum_, the gum of which is certainly different from ammoniacum.
Of the plant itself there are only _fruits_ in the British Museum.

=History=—The first writer to mention ammoniacum is Dioscorides, who
states it to be the juice of a _Narthex_ growing about Cyrene in Libya,
and that it is produced in the neighbourhood of the temple of Ammon.
He says it is of two sorts, the one like frankincense in pure, solid
tears, the other massive, and contaminated with earthy impurities.
Pliny gives essentially the same account.

The succeeding Greek and Latin authors on medicine throw but little
light on the drug, which however is mentioned by most of them as used
in fumigation. Hence we find such terms as _Ammoniacum thymiama_,[1233]
_Ammoniacum suffimen_, _Thus Libycum_.

The African origin assigned to the drug by Dioscorides, has long
perplexed pharmacologists; but it is now well ascertained that in
Morocco a large species of _Ferula_ yields a gum-resin having some
resemblance to ammoniacum, and still an object of traffic with
Egypt and Arabia, where it is employed, like the ancient drug, _in
fumigations_. There can be but little doubt we think, that the
ammoniacum of Morocco is identical with the ammoniacum of the ancients;
it may well have been imported by way of Cyrene from regions lying
further westward.[1234]

Persian ammoniacum or the ammoniacum of European commerce may also have
been known in very remote times, though we are unable to trace it back
earlier than the 10th century, at which period it is mentioned by Isaac
Judæus[1235] and by the Persian physician Alhervi.[1236] Both these
writers designate it _Ushak_, a name which it bears in Persia to the
present day.

=Collection=—The stem of the plant abounds in a milky juice which flows
out on the slightest puncture. The agent which occasions the exudation
is a beetle, multitudes of which pierce the stem. The gum, the drops
of which speedily harden, partly remains adherent to the stem and
partly falls to the ground; it is gathered about the end of July by
the peasants, who sell it to dealers for conveyance to Ispahan or the
coast.[1237]

[1231] Fig. in Bentley and Trimen, part 4.

[1232] _Flora Orientalis_, ii. (1872) 1009.

[1233] Alexander Trallianus in _Puschmann’s_ edition (see appendix)
581. 588.

[1234] Hanbury, _Pharm. Journ._ March 22, 1873. 741; or _Science
Papers_, 375.

[1235] _Opera Omnia_, Lugd. 1515, lib. ii. Practices c. 44.

[1236] Seligmann, _Liber Fundamentorum Pharmacologiæ_, Vindob. 1830. 35.

[1237] Johnson, _Journey from India to England through Persia_, etc.,
1818. 93. 94; Hart, quoted by Don, _Linn. Trans._ xvi. (1833) 605.

Young roots 3 to 4 years old are, according to Borszczow, extremely
rich in milky juice which sometimes exudes into the surrounding soil in
large drops; there is also an exudation from the fibrous crown of the
root of a dark inferior sort of ammoniacum. The gum-resin appears to be
collected in quantity only in Persia. One of the chief localities for
it are the desert plains about Yezdikhast, between Ispahan and Shiraz.

=Description=—Ammoniacum occurs in dry grains or tears of roundish
form, from the size of a small pea to that of a cherry, or in nodular
lumps. They are externally of a pale creamy yellow, opaque and
milky-white within. By long keeping, the outer colour darkens to a
cinnamon-brown. Ammoniacum is brittle, showing when broken a dull waxy
lustre, but it easily softens with warmth. It has a bitter acrid taste,
and a peculiar, characteristic, non-alliaceous odour. It readily forms
a white emulsion when triturated with water. It is coloured yellow by
caustic potash. Hypochlorites, as common bleaching powder, give it a
bright orange hue, while they do not affect the Morocco drug.

Ammoniacum is obtained from the mature plant, the ripe mericarps of
which, ⅜ of an inch in length, are often found sticking to the tears.
By pressure the tears agglutinate into a compact mass, which is the
_Lump Ammoniacum_ of the druggists. It is generally less pure than the
detached grains, and fetches a lower price.

=Chemical Composition=—Ammoniacum is a mixture of volatile oil with
resin and gum. We obtained only ⅓ per cent. of oil which we find to
be dextrogyrate; we failed in obtaining terpin (see Galbanum, p. 322)
from it. The oil has the precise odour of the drug, contains, according
to our experiments, no sulphur; a similar observation was made by
Przeciszewski[1238]. Vigier[1239] asserts that it blackens silver, and
that after oxidation with nitric acid, he detected in it sulphuric
acid. He states that, with hydrochloric acid, the oil acquires a fine
violet tint passing by all shades to black; we failed in obtaining this
coloration. By diluting the oil with bisulphide of carbon, and then
adding mineral acids, we observed only yellow colorations. The oil
diluted with alcohol acquires a reddish hue by ferric chloride.

The resin ammoniacum usually amounts to about 70 per cent.
Przeciszewski asserts that the indifferent resin when heated yields
sulphuretted hydrogen. Our own experiments failed to show the presence
of sulphur in the _crude_ drug; and the same negative result has been
more recently obtained in some careful experiments by Moss[1240]. Water
when boiled with the resin acquires a yellow hue and slightly acid
reaction; the liquid assumes an intense red coloration on addition of
ferric chloride.

Unlike the gum-resin of allied plants, ammoniacum yields no
umbelliferone. When melted with caustic potash it affords a little
resorcin.

The mucilaginous matter of the drug consists of a gum readily soluble
in water and a smaller quantity of about ¼ of an insoluble part, no
doubt identical with that occurring in asafœtida and galbanum. The
aqueous solution of the gum of ammoniacum is very slightly levogyre.

[1238] _Pharmakologische Untersuchungen über Ammoniacum, Sagapenum und
Opopanax_, Dorpat, 1861.

[1239] _Gommes-résines des Ombellifères_ (Thèse), Paris, 1869. 93.

[1240] _Pharm. Journ._ March 29, 1873. 761.

=Commerce=—Ammoniacum is shipped to Europe from the Persian Gulf by way
of Bombay. The exports from the latter place in the year 1871-72 were
453 cwt., all shipped to the United Kingdom. The quantity imported into
Bombay in 1872-73 was 1671 cwt., all from the Persian Gulf.[1241]

=Uses=—The drug is administered as an expectorant and is also used in
certain plasters.

Allied Gum-resins.

_African Ammoniacum._—This is according to Lindley[1242] the product of
_Ferula tingitana_ L., a species growing over all northern Africa as
far as Syria, Rhodus and Chios. It is called _Kelth_ in Morocco, its
product, _Fasay_, being shipped occasionally at Mazagan (el Bridja)
or also at Mogador. This gum-resin is in large, compact, dark masses,
formed of agglutinated tears having a whitish or pale greenish, or a
fawn colour. But there are also seen very impure masses. The weak odour
of the Moroccan drug is not suggestive of true ammoniacum. Moss (1873)
found in a specimen of the former 9 per cent. of gum and 67 per cent.
of resin. It yielded umbelliferone to Hirschsohn (1875), and by melting
it with potash Goldschmiedt (1878) obtained Resorcin and a peculiar
acid, C₁₀H₁₀O₆, which he failed to obtain from true ammoniacum.

_Opopanax_—A gum-resin occurring in hard, nodular, brittle,
earthy-looking lumps of a bright orange-brown hue, and penetrating
offensive odour, reminding one of crushed ivy-leaves. It is commonly
attributed to _Opopanax Chironium_ Koch, a native of Mediterranean
Europe. We have never seen a specimen known to have been obtained
from this plant; but can say that the gum-resin of the nearly
allied _Opopanax persicum_ Boiss., as collected by Loftus at
Kirrind in Western Persia in 1851, has neither the appearance nor
the characteristic odour of officinal opopanax. Powell,[1243] who
endeavoured to trace the origin of the drug, regards it as a product of
Persia.

Opopanax was very common in old pharmacy, but has fallen out of use,
and is now both rare and expensive.[1244]


FRUCTUS ANETHI.

_Semen Anethi_; _Dill Fruits_, _Dill Seeds_; F. _Fruits d’Aneth_; G.
_Dillfrüchte_.

=Botanical Origin=—_Anethum graveolens_ L., (_Peucedanum[1245]
graveolens_ Hiern) an erect, glaucous annual plant, with finely
striated stems, usually to 1 to 1½ feet high, pinnate leaves with
setaceous linear segments, and yellow flowers.

[1241] _Statement of the Trade and Navigation of the Presidency of
Bombay_, 1871-72, and 1872-73.

[1242] As stated by Pereira, _Mat. Medica_, ii. part 2 (1857) p. 186.
See also Hanbury, _Science Papers_, 1876. 376.

[1243] _Economic Products of the Punjab_, i. (1868) 402.

[1244] Further particulars regarding Opopanax and Sagapenum, may be
found in the theses of Przeciszewski (1861) and Vigier (1869), noticed
in our article on Ammoniacum, and Dragendorff’s _Jahresbericht_, 1875.
119. 120.

[1245] Bentham and Hooker (_Gen. Plant._ 919) suppress the genus
_Anethum_, uniting its one solitary species with _Peucedanum_.

It is indigenous to the Mediterranean region, Southern Russia and the
Caucasian provinces, but is found as a cornfield weed in many other
countries, and is frequently cultivated in gardens. It succeeds in
Norway as far north as Throndhjem.

Dill, under the Hindustani name of _Suvā_ or _Sōyah_, is largely grown
in various ports of India, where the plant though of but a few months’
duration, grows to a height of 2 to 3 feet. On account of a slight
peculiarity in the fruit, the Indian plant was regarded by Roxburgh and
De Candolle as a distinct species, and called _Anethum Sowa_, but it
possesses no botanical characters to warrant its separation from _A.
graveolens_.

=History=—Dill is commonly regarded to be the Ἄνηθον of Dioscorides,
the _Anethum_ of Palladius and other ancient writers, as well as of
the New Testament.[1246] In Greece the name Ἄνηθον is at present
applied[1247] to a plant of very similar appearance, _Carum Ridolfia_
Benth. et Hook (_Anethum segetum_ L.). By the later Greeks, the term
Ἄνηθον was also used for dill.[1248]

Dill, as well as coriander, fennel, cumin, and ammi, was in frequent
requisition in Britain in Anglo-Saxon times.[1249] The name is derived
according to Prior[1250] from the old Norse word _dilla_, to _lull_,
in allusion to the reputed carminative properties of the drug. However
this may be, we find the word occurring in the 10th century in the
Vocabulary of Alfric, archbishop of Canterbury.[1251] The words _dill_
and _till_, undoubtedly meaning this drug, were also used in Germany
and Switzerland as early as A.D. 1000.

=Description=—The fruit, which has the characters usual to
_Umbelliferæ_, is of ovoid form, much compressed dorsally, surrounded
with a broad flattened margin. The mericarps about ⅒ of an inch wide,
are mostly separate; they are provided with 5 equidistant, filiform
ridges, of which the two lateral lose themselves in the paler, broad,
thin margin. The three others are sharply keeled; the darkest space
between them is occupied by a vitta and two occur on the commissure.
In the Indian drug, the mericarps are narrower and more convex, the
ridges more distinct and pale, and the border less winged. In other
respects it accords with that of Europe. The odour and taste of dill
are agreeably aromatic.

=Microscopic Characters=—The pericarp is formed of a small number of
flattened cells, which in the inner layer are of a brown colour; the
ridges consist as usual of a strong fibro-vascular bundle. The vittæ
in a transverse section present an elliptic outline ¹/₁₄₀ of an inch
or less in diameter. The margin of the mericarp is built up of porous,
parenchymatous tissue. The albumen as in the seeds of all umbellifers,
consists of thick-walled, angular cells, loaded with fatty oil, and
globular grains of albuminous matters which present a dark cross when
examined by polarized light.

[1246] Matt. xxiii. 23,—where it has been rendered _anise_ by the
English translators from Wicklif (1380) downwards. But in other
versions, the word is correctly translated.

[1247] Heldreich, _Nutzpflanzen Griechenlands_ (1862) 40.

[1248] Langkavel, _Botanik d. späteren Griechen_, Berlin, 1866. 39.

[1249] _Leechdoms_, &c., edited by Cockayne, 1864-66,—see especially
_Herbarium Apuleii_, dating about A.D. 1050, in vol. i. pp. 219. 235.
237. 281. 293.

[1250] _Popular Names of British Plants_, 1870.

[1251] _Volume of Vocabularies_, edited by Wright, 1857. 30.

=Chemical Composition=—Dill fruit yields from 3 to 4 per cent. of an
essential oil, the largest proportion of which was found by Gladstone
(1864-1872) to be a hydrocarbon, C₁₀H₁₆, to which he gave the name
_Anethene_. This substance has a lemon-like odour, sp. gr. ·846, and
boils at 172° C. It deviates a ray of polarized light strongly to the
right. Nietzki (1874) ascertained that there is, moreover, present
another hydrocarbon, C₁₀H₁₆, in a very small proportion, which boils
at 155-160°. A third constituent of oil of dill is in all probability
identical with carvol (see page 307); we prepared from the former
immediately the crystals (C₁₀H₁₄O)₂SH₂.

=Uses=—The distilled water of dill is stomachic and carminative, and
frequently prescribed as a vehicle for more active medicines. The seeds
are much used for culinary and medicinal purposes by the people of
India, but are little employed in Continental Europe.


FRUCTUS CORIANDRI.

_Semen Coriandri_; _Coriander Fruits_, _Coriander Seeds_, _Corianders_;
F. _Fruits de Coriandre_; G. _Koriander_.

=Botanical Origin=—_Coriandrum sativum_ L., a small glabrous, annual
plant, apparently indigenous to the Mediterranean and Caucasian
regions, not known growing wild, but now found as a cornfield weed
throughout the temperate parts of the Old World. It is cultivated in
many countries, and has thus found its way even to Paraguay. In England
the cultivation of coriander has long been carried on, but only to a
very limited extent.

=History=—Coriander appears to occur in the famous Egyptian papyrus
Ebers; it is also mentioned, under the name of Kustumburu, in early
Sanskrit authors, and is also met with in the Scriptures.[1252]

The plant owes its names Κόριον, Κορίαννον, and Κοριάνδρον, or also
in the middle ages, Κλάνδρον, to the offensive odour it exhales when
handled, and which reminds one of bugs,—in Greek Κόρις. This character
caused it to be regarded in the middle ages as having poisonous
properties.[1253] The ripe fruits which are entirely free from the
fœtid smell of the growing plant, were used as a spice by the Jews
and the Romans, and in medicine from a very early period. Cato, who
wrote on agriculture in the 3rd century B.C., notices the cultivation
of coriander. Pliny states that the best is that of Egypt. It is of
frequent occurrence in the book “De opsoniis et condimentis” of Apicius
Cœlius, about the 3rd century of our era. Coriander is also included in
the list of Charlemagne, alluded to pages 92, 98, etc.

Coriander was well known in Britain prior to the Norman Conquest, and
often employed in ancient Welsh and English medicine and cookery.

[1252] Exod. xvi. 31; Num. xi. 7.

[1253] Petrus de Abbano, _Tract. de Venenis_, Venetiis, 1473. capp. 25.
46.

=Cultivation=—Coriander, called by the farmers _Col_, is cultivated in
the eastern counties of England, especially in Essex. It is sometimes
sown with caraway, and being an annual is gathered and harvested the
first year, the caraway remaining in the ground. The seedling plants
are hoed so as to leave those that are to remain in rows 10 to 12
inches apart. The plant is cut with sickles, and when dry the seed is
thrashed out on a cloth in the centre of the field. On the best land,
15 cwt. per acre is reckoned an average crop.[1254]

[1254] R. Baker, in Morton’s _Cyclopædia of Agriculture_, i. (1855) 545.

=Description=—The fruit of coriander consists of a pair of
hemispherical mericarps, firmly joined so as to form an almost regular
globe, measuring on an average about ⅕ of an inch in diameter, crowned
by the stylopodium and calycinal teeth, and sometimes by the slender
diverging styles. The pericarp bears on each half, 4 perfectly straight
sharpish ridges, regarded as secondary (_juga secundaria_); two other
ridges, often of darker colour, belonging to the mericarps in common,
the separation of which takes place in a rather sinuous line. The
shallow depression between each pair of these straight ridges is
occupied by a zigzag raised line (_jugum primarium_), of which there
are therefore 5 in each mericarp. It will thus be seen that each
mericarp has 5 (zigzag) so-called _primary ridges_, and 4 (keeled and
more prominent) _secondary_, besides the lateral ridges which mark the
suture or line of separation. There are no vittæ on the outer surface
of the pericarp. Of the 5 teeth of the calyx, 2 often grow into long,
pointed, persistent lobes; they proceed from the outer flowers of the
umbel.

Though the two mericarps are closely united, they adhere only by the
thin pericarp, enclosing when ripe a lenticular cavity. On each side
of this cavity, the skin of the fruit separates from that of the seed,
displaying the two brown vittæ of each mericarp. In transverse section,
the albumen appears crescent-shaped, the concave side being towards the
cavity. The carpophore stands in the middle of the latter as a column,
connected with the pericarp only at top and bottom.

Corianders are smooth and rather hard, in colour buff or light brown.
They have a very mild aromatic taste, and, when crushed, a peculiar
fragrant smell. When unripe, their odour, like that of the fresh plant,
is offensive. The nature of the chemical change that occasions this
alteration in odour has not been made out.

The Indian corianders shipped from Bombay are of large size and of
elongated form.

=Microscopic Structure=—The structural peculiarities of coriander fruit
chiefly refer to the pericarp. Its middle layer is made up of thick
walled ligneous prosenchyme, traversed by a few fibro-vascular bundles
which in the zigzag ridges vary exceedingly in position.

=Chemical Composition=—The essential oil of coriander has a composition
indicated by the formula C₁₀H₁₈O, and is therefore isomeric with
borneol. If the elements of water are abstracted by phosphoric
anhydride, it is converted, according to Kawalier (1852), into an oil
of offensive odour, C₁₀H₁₆.

The fruits yield of volatile oil from 0·7 to 1·1 per cent.; as the
vittæ are well protected by the woody pericarp, corianders should be
bruised before being submitted to distillation. Trommsdorff (1835)
found the fruits to afford 13 per cent. of fixed oil.

The fresh herb distilled in July when the fruits were far from ripe,
yielded to one of us (F.) from 0·57 to 1·1 per mille of an essential
oil possessing in a high degree the disagreeable odour already alluded
to. This oil was found to deviate the ray of polarized light 1·1° to
the right when examined in a column 50 mm. long. The oil distilled by
us from ripe commercial fruit deviated 5·1° to the right.

=Production and Commerce=—Coriander is cultivated in various parts
of Continental Europe, and, as already stated, to a small extent in
England. It is also produced in Northern Africa and in India. In
1872-73, the export of coriander from the province of Sind[1255]
was 948 cwt.; from Bombay[1256] in the same year 619 cwt. From
Calcutta[1257] there were shipped in 1870-71, 16,347 cwt.

=Uses=—Coriander fruits are reputed stimulant and carminative, yet are
but little employed in medicine. They are however used in veterinary
practice, and by the distillers of gin, also in some countries in
cookery.


FRUCTUS CUMINI.

    _Fructus vel Semen Cymini_; _Cumin or
        Cummin[1258] Fruits_, _Cummin Seeds_; F.
        _Graines de Cumin_; G. _Mutterkümmel_,
        _Kreuzkümmel_, _Langer oder Römischer
        Kümmel_, _Mohrenkümmel_.

=Botanical Origin.=—_Cuminum Cyminum_ L., a small annual plant,
indigenous to the upper regions of the Nile, but carried at an early
period by cultivation to Arabia, India and China, as well as to the
countries bordering the Mediterranean. The fruits of the plant ripen
as far north as Southern Norway; but in Europe, Sicily and Malta alone
produce them in quantity.

=History=—Cumin was well known to the ancients; it is alluded to by
the Hebrew prophet Isaiah,[1259] and is mentioned in the gospel of
Matthew[1260] as one of the minor titheable productions of the Holy
Land. Under the name Κύμινον, it is commended for its agreeable taste
by Dioscorides, in whose day it was produced on the coasts of Asia
Minor and Southern Italy. It is named as _Cuminum_ by Horace and
Persius; Scribonius Largus, in the first century of our era, mentions
Cuminum æthiopicum, silvaticum and thebaicum.

During the middle ages, cumin was one of the spices in most common
use. Thus in A.D. 716, an annual provision of 150 lb. of cumin for
the monastery of Corbie in Normandy, was not thought too large a
supply.[1261] Edrisi mentioned cumin as a product of Morocco (see
article Fructus Carui, p. 305), Algeria and Tunisia. It was in frequent
use in England, its average price between 1264 and 1400 being a little
over 2_d._ per lb.[1262] Cumin is enumerated in the _Liber albus_[1263]
of the city of London, compiled in 1419, among the merchandize on which
the king levied the impost called _scavage._ It is mentioned[1264]
in 1453 as one of the articles of which the Grocers’ Company had the
weighing and oversight, and was classed in 1484 in the same way in the
German warehouse in Venice.[1265]

[1255] _Statement of the Trade and Navigation of Sind for the year
1872-73_, Karachi, 1873. 36.

[1256] Ditto for Bombay, 1872-73. ii. 90.

[1257] _Annual Volume of Trade, etc. for the Bengal Presidency_,
1870-71. 121.

[1258] _Comyne_ in Wicklif’s Bible (1380), _Commen_ in Tyndale’s
(1534), _Commyn_ in Cranmer’s (1539), _Cummine_ in the Authorised
Version (1611), _Cumin_ in Gerarde’s _Herbal_ (1636) and Paris’s
_Pharmacologia_ (1822), _Cummin_, Ray (1693) and in modern trade-lists
and price-currents.

[1259] Ch. xxviii. 25-27.

[1260] Ch. xxiii. 23.

[1261] Pardessus, _Diplomata_, etc., Paris, 1849. ii. 309.

[1262] Rogers, _Hist. of Agriculture and Prices in England_, 1876. i.
631, ii. 543-547.

[1263] _Munimenta Gildhallæ Londoniensis_, edited by Riley, i. (1859)
224.

[1264] Herbert, _Hist. of the Great Livery Companies of London_, 1834.
114.

[1265] Thomas, _Fontego dei Todeschi in Venezia_, 1874. 252.

=Description=—The fruit, the colour of which is brown, has the usual
structure of the order; it is of an elongated ovoid form, tapering
towards each end, and somewhat laterally compressed. The mericarps,
which do not readily separate from the carpophore, are about ¼ of
an inch in length and ⅒ of an inch in greatest breadth. Each has 5
primary ridges which are filiform, and scabrous or muriculate, and 4
secondary covered with rough hairs. Between the primary ridges is a
single elongated vitta, and 2 vittæ occur on the commissural surface.
A transverse section of the seed shows a reniform outline. There is a
form of _C. Cyminum_ in cultivation, the fruit of which is perfectly
glabrous.

Cumin has a strong aromatic taste and smell, far less agreeable than
that of caraway.

=Microscopic Structure=—The hairs are rather brittle, sometimes ½ mm.
in length, formed of cells springing from the epidermis. The larger
consists of groups of cells, vertically or laterally combined, and
enclosed by a common envelope; the smaller of but a single cell ending
in a rounded point. The whole pericarp is rich in tannic matter,
striking with salts of iron a dark greenish colour.

The tissue of the seed is loaded with colourless drops of a fatty oil;
the vittæ with a yellowish-brown essential oil. But the most striking
contents of the parenchyme of the albumen consist of transparent,
colourless, spherical grains, 7 to 5 mkm. in diameter, several of which
are enclosed in each cell. Under a high magnifying power, they show a
central cavity with a series of concentric layers around it, frequently
traversed by radial clefts. Examined in polarized light, these grains
display exactly the same cross as is seen in granules of starch,
although their behaviour with chemical tests at once proves that they
are by no means that substance; in fact iodine does not render them
blue, but intensely brown. Grains of the same character, assuming
sometimes a crystalloid form, occur in most umbelliferous fruits,
and in many seeds of other orders. All these bodies are composed of
albuminous and fatty matters; the more crystalloid form as met with in
the seeds of _Ricinus_ and in the fruit of parsley, is the body called
by Hartig _Aleuron_.

=Chemical Composition=—Cumin fruits yielded to Bley (1829) 7 per cent.
of fat oil, 13 per cent. of resin (?), 8 of mucilage and gum, 15 of
albuminous matter, and a large amount of malates. Their peculiar,
strong, aromatic smell and taste, depend on the essential oil of which
they afford as much as 4 per cent. It contains about 56 per cent. of

    _Cuminol_ (or _Cuminaldehyde_), C₆H₄ {CHO,
                                         {C₃H₇

a liquid of sp. gr. 0·972, boiling point 237° C. It has also been met
with, in 1858, by Trapp in the oil of Cicuta virosa. By boiling cuminol
with potash in alcoholic solution,

    cuminalcohol, C₆H₄ {CH₂OH,
                       {C₃H₇

as well as the potassium salt of cuminic acid,

         {COOH
    C₆H₄ {        , are formed.
         {C₃H₇

The oil of cumin, secondly, contains a mixture of hydrocarbons. That
which constitutes about one-half of the crude oil has been first
obtained in 1841 by Gerhardt and Cahours, just from the oil under
notice, and therefore called _Cymene_ (or also _Cymol_). It is a liquid
of 0·873 sp. gr. at 0° (32° F.), boiling at 175°; neither cymene nor
cuminol have the same odour and taste as the crude oil. Many other
plants have been noticed as containing cymene among the constituents
of their essential oils. Thus for instance _Cicuta virosa_ L.,
_Carum Ajowan_ (page 304), _Thymus vulgaris_ (see art. Folia Thymi),
_Eucalyptus globulus_ Labill.

    Cymene, C₆H₄ {CH₃ (Propylmethyl-benzol),
                 {C₃H₇

may also be artificially obtained from a large number of essential oils
having the composition C₁₀H₁₆, or C₁₀H₁₄O, or C₁₀H₁₆O, or C₁₀H₁₈O. It
differs very remarkably from the oils of the formula C₁₀H₁₆, inasmuch
as cymene yields the crystallizable cymen-sulphonic acids when it is
warmed with concentrated sulphuric acid.

Lastly, there is present in the oil of cumin a small amount of a
terpene, C₁₀H₁₆, boiling at 155·8° C., as stated in 1865 by C. M.
Warren, and in 1873 by Beilstein and Kupffer.

The dextrogyrate power of cuminol is a little less strong than that of
cymene; artificial cymene is optically inert.

=Commerce=—Cumin is shipped to England from Mogador, Malta and Sicily.
In Malta there were in 1863, 140 acres under cultivation with this
crop; in 1865, 730 acres, producing 2766 cwt.[1266]

The export of cumin from Morocco[1267] in 1872 was 1657 cwt.; that from
Bombay in the year 1872-73 was 6766 cwt.;[1268] and 20,040 cwt. from
Calcutta[1269] in the year 1870-71.

=Uses=—Cumin is sold by druggists as an ingredient of curry powders,
but to a much larger extent for use in veterinary medicine.




CAPRIFOLIACEÆ.


FLORES SAMBUCI.

_Elder Flowers_; F. _Fleurs de Sureau_; G. _Holunderblüthe_,
_Fliederblumen_.

=Botanical Origin=—_Sambucus nigra_ L.—a large deciduous shrub or
small tree, indigenous to Southern and Central Europe (not in Russia),
Western Asia, the Crimea, the regions of the Caucasus and Southern
Siberia. It is believed to be a native of England and Ireland, but not
to be truly wild in Scotland. In other northern parts of Europe, as
Norway and Sweden, the elder appears only as a plant introduced there
during the middle ages by the monks.[1270]

[1266] _Statistical Tables relating to the Colonial and other
possessions of the United Kingdom_, xi. 618. 619.

[1267] _Consular Reports_, Aug. 1873, 917; in 1876 only 380 cwt.

[1268] _Statement of the Trade and Navigation of the Presidency of
Bombay for 1872-73._ pt. ii. 90.

[1269] _Annual Volume of Trade, etc. for the Bengal Presidency for
1870-71._ 121.

[1270] Schübeler, _Pflanzenwelt Norwegens_ (1873-75) 253.

=History=—The Romans, as we learn from Pliny, made use in medicine of
the plant under notice as well as of the _Dwarf Elder_ (_S. Ebulus_
L.) Both kinds were employed in Britain by the ancient English[1271]
and Welsh[1272] leeches, and in Italy in the medicine of the school of
Salernum.

=Description=—The elder produces in the early summer, conspicuous,
many-flowered cymes, 4 to 5 inches in diameter, of which the long
peduncle divides into 5 branches, which subdivide once or several
times by threes or fives, ultimately separating by repeated forking
into slender, furrowed pedicels about ¼ of an inch long, each bearing
a single flower. In the second or third furcations, the middle flower
remains short-stalked or sessile, and opens sooner than the rest. In
like manner, on the outermost small forks only one of the florets is
usually long-stalked. The whole of this inflorescence forms a flattish
umbelliform cyme, perfectly glabrous and destitute of bracts.

The calyx is combined with the ovary and bordered with 4 or 5 small
teeth. The corolla, which is of a creamy white, is monopetalous with
a very short tube and 5 spreading ovate lobes. The stamens which are
about as long as the divisions of the corolla and alternate with
them, are inserted in the tube of the latter. The yellow pollen which
thickly powders the flowers, appears under the microscope 3-pored. The
projecting ovary is crowned by a 2-or 3-lobed sessile stigma.

For use in pharmacy, the part of the flower most desirable is the
corolla, to obtain a good proportion of which the gathered cymes are
left for a few hours in a large heap; the mass slightly heats, the
corollas detach themselves, and are separated from the green stalks by
shaking, rubbing, and sifting; they require to be then rapidly dried.
This done, they become much shrivelled and assume a dull yellow tint.
When fresh, they have a sweet faint smell, which becomes stronger and
somewhat different by drying, and is quite unlike the repulsive odour
of the fresh leaves and bark. Dried elder flowers have a bitterish,
slightly gummy flavour. On the Continent they are sold with the stalks,
_i.e._ in entire cymes.

=Chemical Composition=—Elder flowers yield a very small percentage of a
butter-like essential oil, lighter than water, and smelling strongly of
the flowers; it is easily altered by exposure to the air.[1273] The oil
is accompanied by traces of volatile acids.

=Uses=—Elder flowers are only employed in British medicine for making
an aromatic distilled water, and for communicating a pleasant odour
to lard (_Unguentum Sambuci_). The flowers of _Sambucus canadensis_
L.[1274] indigenous in the United States, which are extremely similar
to those of our species, appear to be more fragrant. The _leaves_ of
the latter are sometimes used for giving a fine green tint to oil or
fat, as in the _Oleum viride_ and _Unguentum Sambuci foliorum_ of the
shops. The bark, once much employed, is now obsolete.

[1271] _Leechdoms, etc. of Early England_ edited by Cockayne, iii.
(1866) 324. 347. According to the Rev. Edward Gillett (p. xxxii.), _S.
Ebulus_ is believed to have been brought to England by the Danes and
planted on the battlefield and graves of their countrymen. In Norfolk
it still bears the name of _Danewort_ and _blood hilder_ (blood elder).

[1272] The Physicians of Myddfai (see Appendix) used sage, rue, mallow,
and _elder flowers_ as ingredients of a gargle. _Meddygon Myddvai_,
219. 403.

[1273] For further information, see Gmelin, _Chemistry_, xiv. (1860)
368.

[1274] Fig. in Bentley and Trimen, _Med. Plants_, part 21 (1877).




RUBIACEÆ.


GAMBIER.

    _Catechu pallidum_, _Extractum Uncariæ_;
        _Gambier_, _Pale Catechu_,
        _Gambier Catechu_, _Terra Japonica_;
        F. _Gambir_, _Cachou jaune_; G.
        _Gambir_.

=Botanical Origin=—1. _Uncaria Gambier_ Roxb. (_Nauclea Gambir_ Hunter)
a stout climbing shrub, supporting itself by means of its flower-stalks
which are developed into strong recurved hooks.[1275] It is a native of
the countries bordering the Straits of Malacca, and especially of the
numerous islands at their eastern end; but according to Crawfurd[1276]
it does not seem indigenous to any of the islands of the volcanic band.
It also grows in Ceylon, where however no use is made of it.

2. _U. acida_ Roxb.,[1277] probably a mere variety of the preceding,
and growing in the Malayan islands, appears to be used in exactly the
same manner.

=History=—Gambier is one of the substances to which the name of
_Catechu_ or _Terra Japonica_ is often applied; the other is
_Cutch_, which has been already described (p. 243). By druggists and
pharmaceutists the two articles are frequently confounded, but in the
great world of commerce they are reckoned as quite distinct. In many
price-currents and trade-lists, _Catechu_ is not found under that name,
but only appears under the terms _Cutch_ and _Gambier_.

Crawfurd asserts that gambier has been exported from time immemorial
to Java from the Malacca Straits. This statement appears highly
questionable. Rumphius, who resided in Amboyna during the second half
of the 17th century, was a merchant, consul and naturalist; and in
these capacities became thoroughly conversant with the products of the
Malay Archipelago and adjacent regions, as the six folio volumes of his
_Herbarium Amboinense_, illustrated by 587 plates, amply prove.

Among other plants, he figures[1278] _Uncaria Gambier_, which he terms
_Funis uncatus_, and states to exist under two varieties, the one with
broad, and the other with narrow leaves. The first form, he says, is
called in Malay _Daun Gatta Gambir_, on account of the bitter taste
of its leaves, which is perceptible in the lozenges (_trochisci_)
called _Gatta Gambir_, so much so that one might suppose they were made
from these leaves, which however is not the case. He further asserts
that the leaves have a detergent, drying quality by reason of their
bitterness, which is nevertheless not intense but quite bearable in
the mouth: that they are masticated instead of _Pinang_ [Betel-nut]
with _Siri_ [leaf of _Piper Betle_] and lime: that the people of Java
and Bali plant the first variety near their houses for the sake of its
fragrant flowers; but though they chew its leaves instead of _Pinang_,
it must not be supposed that it is this plant from which the lozenges
_Gatta_ are compounded, for that indeed is quite different.

[1275] Fig. in Bentley and Trimen, _Med. Plants_, part 7 (1876).

[1276] _Dictionary of the Indian Islands_, 1865. 142.

[1277] Beautifully figured in Berg und Schmidt, _Offizinelle Gewächse_,
xxx. c. 1863.

[1278] _Herb. Amb._ v. 63. tab. 34.

Thus, if we may credit Rumphius, it would seem that the important
manufacture of gambier had no existence at the commencement of the last
century. As to “_Gatta Gambir_,” his statements are scarcely in accord
with those of more recent writers. We may however remark that that name
is very like the Tamil _Katta Kāmbu_, signifying _Catechu_, which drug
is sometimes made into little round cakes, and was certainly a large
export from India to Malacca and China as early as the 16th century (p.
241).

That gambier was unknown to Europeans long after the time of Rumphius,
is evident from other facts. Stevens, a merchant of Bombay, in his
_Compleat Guide to the East India Trade_, published in 1766, quotes the
prices of goods at Malacca, but makes no allusion to gambier. Nor is
there any reference to it in Savary’s _Dictionnaire de Commerce_ (ed.
of 1750), in which Malacca is mentioned as the great entrepôt of the
trade of India with that of China and Japan.

The first account of gambier known to us, was communicated to the
Batavian Society of Arts and Sciences in 1780, by a Dutch trader named
Couperus. This person narrates[1279] how the plant was introduced into
Malacca from Pontjan in 1758, and how gambier is made from its leaves;
and names several sorts of the drug and their prices.

In 1807, a description of “the drug called _Gutta Gambeer_,” and of
the tree from which it is made, was presented to the Linnean Society
of London.[1280] The writer, William Hunter, well known for scientific
observations in connection with India, states that the substance is
made chiefly at Malacca, Siak and Rhio, that it is in the form of small
squares, or little round cakes almost perfectly white, and that the
finer sorts are used for chewing with betel leaf in the same manner as
catechu, while the coarser are shipped to Batavia and China for use in
tanning and dyeing.

=Manufacture=—The gambier plant is cultivated in plantations. These
were commenced in 1819 in Singapore, where there were at one time
800 plantations; but owing to scarcity of fuel, without an abundant
supply of which the manufacture is impossible, and dearness of labour,
gambier-planting was in 1866 fast disappearing from the island.[1281]
The official Blue Book, printed at Singapore in 1872, reports it as
“_much increased_.” It is largely pursued on the mainland (Johore),
and in the islands of the Rhio-Lingga Archipelago, lying south-east of
Singapore. On the island of Bintang, the most northerly of the group,
there were about 1,250 gambier-plantations in 1854.

The plantations are often formed in clearings of the jungle, where
they last for a few years and are then abandoned,[1282] owing to
the impoverishment of the soil and the irrepressible growth of the
_lalang_ grass (_Imperata Königii_ P. de B.), which is more difficult
to eradicate than even primæval jungle. It has been found profitable to
combine with the cultivation of gambier that of pepper, for which the
boiled leaves of the gambier form an excellent manure.

[1279] _Verhandelingen van het Bataviaasch Genootschap_, ii. (derde
druk) 217-234.

[1280] _Linn. Trans._ ix. (1808) 218-224.

[1281] Collingwood, _Journ. of Linn. Soc._, Bot., x. (1869) 52.

[1282] This abuse of land has been repressed in Singapore.

The gambier plants are allowed to grow 8 to 10 feet high, and as their
foliage is always in season, each plant is stripped 3 or 4 times in
the year. The apparatus and all that belongs to the manufacture of
the extract are of the most primitive description.[1283] A shallow
cast-iron pan about 3 feet across is built into an earthen fireplace.
Water is poured into the pan, a fire is kindled, and the leaves and
young shoots, freshly plucked, are scattered in, and boiled for about
an hour. At the end of this time they are thrown on to a capacious
sloping trough, the lower end of which projects into the pan, and
squeezed with the hand so that the absorbed liquor may run back into
the boiler. The decoction is then evaporated to the consistence of
a thin syrup, and baled out into buckets. When sufficiently cool it
is subjected to a curious treatment:—instead of simply stirring it
round, the workman pushes a stick of soft wood in a sloping direction
into each bucket; and placing two such buckets before him, he works a
stick up and down in each. The liquid thickens round the stick, and
the thickened portion being constantly rubbed off, while at the same
the whole is in motion, it gradually sets into a mass, a result which
the workman affirms would never be produced by simple stirring round.
Though we are not prepared to concur in the workman’s opinion, it is
reasonable to suppose that his manner of treating the liquor favours
the crystallization of the catechin in a more concrete form than it
might otherwise assume. The thickened mass, which is said by another
writer to resemble soft yellowish clay, is now placed in shallow square
boxes, and when somewhat hardened is cut into cubes and dried in the
shade. The leaves are boiled a second time, and finally washed in
water, which water is saved for another operation.

From informations obtained in 1878 it would appear that now the
prevailing part of gambier is made by means of pressure into blocks.

A plantation with five labourers contains on an average 70,000 to
80,000 shrubs, and yields 40 to 50 catties (1 catty = 1⅓ lb. = 604·8
grammes) of gambier daily.

=Description=—Gambier is an earthy-looking substance of light brown
hue, consisting of cubes about an inch each side, more or less
agglutinated, or it is in the form of entirely compact masses. The
cubes are externally of a reddish-brown and compact, internally of a
pale cinnamon hue, dry, porous, friable, devoid of odour, but with a
bitterish astringent taste, becoming subsequently sweetish. Under the
microscope, the cubes of gambier are seen to consist of very small
acicular crystals.

=Chemical Composition=—In a chemical point of view, gambier agrees with
cutch, especially with the pale variety made in Northern India (p.
242). Both substances consist mainly of _Catechin_,[1284] which may
be obtained in the hydrated state as slender colourless needles, by
exhausting gambier with cold water, and crystallizing the residue from
3 or 4 parts of hot water, which on cooling deposits nearly all the
catechin. Ferric chloride strikes with the solution of catechin, even
when much diluted, a green tint. If it is shaken with ferrous sulphate
and an extremely small quantity of bicarbonate of sodium, a violet
colour makes its appearance. The same reactions are produced by various
substances of the tannic class.

[1283] We borrow the following account, which is the best we have met
with, from Jagor’s _Singapore, Malacca, und Java_, Berlin, 1866. 64.

[1284] Gautier (1877) suggests that it is not identical with catechin
from Acacia Catechin (p. 244).

The yellowish colouring matter of gambier was determined by Hlasiwetz
(1867) and Löwe (1873) to be _Quercetin_, which is also a constituent
of cutch. Quercetin is but very sparingly soluble in water, yet it is
nevertheless found, in small quantity, in the aqueous extract of cutch,
from which it may be removed by means of ether. As many species of
_Nauclea_ contain, according to De Vry,[1285] _Quinovic Acid_, it is
probable that that substance may be detected in gambier.

Some fine gambier in regular cubes which we incinerated left 2·6 per
cent. of ash, consisting mainly of carbonates of calcium and magnesium.

=Commerce=—Singapore, which is the great emporium for gambier, exported
in 1871 no less than 34,248 tons, of which quantity 19,550 tons had
been imported into the colony chiefly from Rhio and the Malayan
Peninsula.[1286] In 1876 the export had increased to more than 50,000
tons of pressed block gambier and 2,700 tons of cubes. In 1877 it
diminished to 39,117 tons, owing to difficulties which had arisen
between the Chinese dealers, who supplied the drug in a rather wet
state, and the European exporters. Of the above quantity 21,607 tons
were shipped for London, 7,572 for Liverpool, 2,345 for Marseilles.
Gambier usually fetches a lower price[1287] in the London market than
cutch.

The quantity imported into the United Kingdom in 1872 was 21,155 tons,
value £451,737, almost the whole being from the Straits Settlements.

=Uses=—Gambier, under the name of _Catechu_, is used medicinally as an
astringent, but the quantity thus consumed is as nothing in comparison
with that employed for tanning and dyeing.

[1285] _Pharm. Journ._ vi. (1865) 18.

[1286] _Blue Book of the Colony of the Straits Settlements for 1871._

[1287] 17_s._ per cwt., March 1879; see Catechu, page 242, note 3.


CORTEX CINCHONÆ.

_Cortex Peruvianus_, _Cortex Chinæ_; _Cinchona Bark_, _Peruvian Bark_;
F. _Ecorce de Quinquina_; G. _Chinarinde_.

=Botanical Origin=—The genus _Cinchona_ constitutes together with
_Cascarilla_ (including _Buena_ and _Cosmibuena_), _Remijia_,
_Ladenbergia_, _Macrocnemum_, and about 30 other nearly allied genera,
the well-characterized tribe _Cinchoneæ_ of the order _Rubiaceæ_. This
tribe consists of shrubs or trees with opposite leaves, 2-celled ovary,
capsular fruit, and numerous minute, vertical or ascending, peltate,
winged, albuminous seeds.

(=A.=) _Remarks on the genus._—The genus _Cinchona_ is distinguished by
deciduous stipules, flowers in terminal panicles, 5-toothed superior
calyx, tubular corolla expanding into 5 lobes fringed at the margin.
The corolla is of an agreeable weak odour, and of a rosy or purplish
hue or white. The fruit is a capsule of ovoid or subcylindrical form,
dehiscing from the base (the fruit-stalk also splitting) into two
valves, which are held together at the apex by the thick permanent
calyx. The seeds, 30 to 40 in number, are imbricated vertically;
they are flat, winged all round by a broad membrane, which is very
irregularly toothed or lacerated at the edge.

The Cinchonas are evergreen, with finely-veined leaves, traversed by a
strong midrib. The thick leafstalk, often of a fine red, is sometimes a
sixth the length of the whole leaf, but usually shorter. The leaves are
ovate, obovate, or nearly circular; in some species lanceolate, rarely
cordate, always entire, glabrous or more rarely hirsute, often variable
as to size and form in the same species.

Among the valuable species, several are distinguished by small pits
called _scrobiculi_, situated on the under side of the leaf, in the
axils of the veins which proceed from the midrib. These pits sometimes
exude an astringent juice. In some species they are replaced by tufts
of hair. The young leaves are sometimes purplish on the under side; in
several species the full-grown foliage assumes before falling, rich
tints of crimson or orange.

The species of Cinchona are so much alike that their definition is
a matter of the utmost difficulty, and only to be accomplished by
resorting to a number of characters which taken singly are of no great
importance. Individual species are moreover frequently connected
together by well-marked and permanent intermediate forms, so that
according to the expression of Howard, the whole form a continuous
series, the terminal members of which are scarcely more sharply
separated from the allied genera, than from plants of their own series.

As to the number and value of the species known, there is some
diversity of view. Weddell, in 1870, enumerated 33 species and 18
sub-species, besides numerous varieties and sub-varieties. Bentham and
Hooker, in 1873, estimated the species as about 36.

Kuntze, in the book quoted at the end of the present article, proposed
to reduce all the species to the four following:

    1. _Cinchona Weddelliana_ O. Kuntze, nearly answering
        to _C. Calisaya_ Weddell.

    2. _C. Pavoniana_ O. Kuntze, including _C.
        micrantha_ Ruiz and _Pavon_ and several allied
        plants.

    3. _C. Howardiana_ O. Kuntze, constituted of _C.
        succirubra_ Pavon and a few other species of former
        authors.

    4. _C. Pahudiana_ Howard.

Kuntze, who has examined the living Cinchonæ as cultivated in India, is
of the opinion that all the numerous forms hitherto observed, both in
the wild plants and in cultivation, are merely either belonging to the
above four species or deriving from them chiefly by hybridation. Though
much in favour of a reduction of the species, we are not yet prepared
to accept Kuntze’s arrangement.

(=B.=) _Area, Climate and Soil._—The Cinchonas are natives of South
America, where they occur exclusively on the western side of the
continent between 10° N. lat. and 22° S. lat., an area which includes
portions of Venezuela, New Granada, Ecuador, Peru, and Bolivia.

The plants are found in the mountain regions, no species whatever
being known to inhabit the low alluvial plains. In Peru and Bolivia,
the region of the Cinchona forms a belt, 1300 miles in length,
occupying the eastern slope of the Cordillera of the Andes.[1288]
In Ecuador and New Granada, the tree is not strictly limited to the
eastern slopes, but occurs on other of the Andine ranges.

The average altitude of the cinchoniferous region is given by Weddell
as 5,000 to 8,000 feet above the sea-level. The highest limit, as noted
by Karsten, is 11,000 feet. One valuable species, _C. succirubra_,
occurs exceptionally as low as 2,600 feet. Generally, it may be said
that the altitude of the Cinchona zone decreases in proportion as it
recedes from the equator, and that the most valuable sorts are not
found lower than 5,000 feet.

The climate of the tropical mountain regions in which the Cinchonas
flourish, is extremely variable,—sunshine, showers, storms, and thick
mist, alternating in rapid succession, yet with no very great range
of temperature. A transient depression of the thermometer even to the
freezing point, and not unfrequent hail-showers, may be borne without
detriment by the more hardy species. Yet the mean temperature most
favourable for the generality of species, appears to be 12 to 20° C.
(54 to 68° F.)

Climatic agencies appear to influence the growth of Cinchona far more
than the composition of the soil. Though the tree occurs in a great
variety of geological formations, there is no distinct evidence that
these conditions control in any marked manner either the development
of the tree or the chemical constitution of its bark. Manure on the
other hand, though not increasing perceptibly luxuriance of growth,
has a decided effect in augmenting the richness of the bark in
alkaloids.[1289]

(=C.=) _Species yielding officinal barks._—The Cinchona Barks of
commerce are produced by about a dozen species; of these barks the
greater number are consumed solely in the manufacture of quinine. Those
admitted for pharmaceutical use are afforded by the following species:—

1. _Cinchona officinalis_ Hooker[1290]—A native of Ecuador and Peru,
existing under several varieties. It forms a large tree, having
lanceolate or ovate leaves, usually pointed, glabrous, and shining
on the upper surface, and scrobiculate on the under. The flowers are
small, pubescent and in short lax panicles, and are succeeded by oblong
or lanceolate capsules, ½ an inch or more in length.

2. _C. Calisaya_ Weddell—Discovered by Weddell in 1847,[1291] although
its bark had been an object of commerce since the latter half of the
previous century.

[1288] That is to say the _eastern_ Cordillera, the western and lower
range being called the _Cordillera of the Coast_; no Cinchonas grow on
the latter.

[1289] Broughton, in _Pharm. Journ._ Jan. 4, 1873. 521.

[1290] Figured in _Bot. Magazine_, vol. 89 (1863) tab. 5364, including
_C. Condaminea_ Humb. et Bonpl. and _C. Uritusinga_ Pavon.

[1291] _Ann. des Sciences nat._, Bot. x. (1848) 6, and _Hist. nat. des
Quinquinas_, 1849, tab. 3, figured in _Botanical Magazine_, 1873. 6052,
and 1879. 6434.

The tree inhabits the warmest woods of the declivities which border
the valleys of Bolivia and South-eastern Peru, at an altitude of 5000
to 6000 feet above the sea-level. More precisely, the chief localities
for the tree are the Bolivian provinces of Enquisivi, Yungas de la
Paz, Larecaja or Sorata, Caupolican or Apolobamba, and Muñecas: thence
it passes northward into the Peruvian province of Carabaya, suddenly
ceasing on the confines of the valley of Sandia, although, as Weddell
observed, the adjacent valleys are to all appearance precisely similar.

When well grown, _C. Calisaya_ has a trunk often twice as thick as a
man’s body, and a magnificent crown of foliage overtopping all other
trees of the forest. It has ovate capsules of about the same length (½
an inch) as the elegant pinkish flowers, which are in large pyramidal
panicles. The leaves are 3 to 6 inches long, of very variable form, but
usually oblong and obtuse, rarely acute.

A variety named after Joseph de Jussieu who first noticed it, β.
_Josephiana_, but known in the country as _Ichu-Cascarilla_ or
_Cascarilla del Pajonal_, differs from the preceding in that it is a
shrub, 6 to 10 feet high, growing on the borders of mountain meadows
and of thickets in the same regions as the larger form.

Other forms known in Bolivia as _Calisaya zamba_, _morada_, _verde_ or
_alta_, and _blanca_, have been distinguished by Weddell as varieties
of _C. Calisaya_.

Towards the middle of the year 1865, _Charles Ledger_, an English
traveller, obtained seeds of a superior Cinchona, which had been
collected near Pelechuco, eastwards of the lake Titicaca, about 68° W.
long. and 15° S. lat., in the Bolivian province of Caupolican. In the
same year the seeds arrived in England, but were subsequently sold to
the Dutch government, and raised with admirable success in Java, and
a little later also in private plantations in British India. The bark
of “_Cinchona Ledgeriana_” has since proved by far the most productive
in quinine of all Cinchona Barks. The tree is a mere form of C.
Calisaya.[1292]

3. _C. succirubra_ Pavon,[1293]—a magnificent tree, 50 to 80 feet high,
formerly growing in all the valleys of the Andes which debouch in the
plain of Guayaquil. The tree is now almost entirely confined to the
forests of Guaranda on the western declivities of Chimborazo, at 2,000
to 5,000 feet above the level of the sea.

The bark appears to have been appreciated in its native country at an
early period, if we may conclude that the _Red Bark_ mentioned by La
Condamine in 1737 was that under notice. It would seem, however, to
have scarcely reached Europe earlier than the second half of the last
century.[1294] The tree has broadly oval leaves, attaining about a foot
in length, nearly glabrous above, pubescent beneath, large terminal
panicles of rosy flowers, succeeded by oblong capsules 1 to 1¼ inches
long.

The other species of _Cinchona_, the bark of which is principally
consumed by the manufacturers of quinine, will be found briefly
noticed, together with the foregoing, in the conspectus at page 355.

=History=—The early native history of Cinchona is lost in obscurity. No
undoubted proofs have been handed down, to show that the aborigines of
South America had any acquaintance with the medicinal properties of the
bark. But traditions are not wanting.

[1292] Ledger’s Calisaya is beautifully figured and exactly described
in Howard’s _Quinology of the East Indian Plantations_, parts ii. and
iii.

[1293] Figured in Howard’s _Nueva Quinologia_, art. _Chinchona
succirubra_.

[1294] Howard, _l.c._ p. 9.

William Arrot,[1295] a Scotch surgeon who visited Peru in the early
part of the last century, states that the opinion then current at Loxa
was that the qualities and use of the barks of Cinchona were known to
the Indians before any Spaniard came among them. Condamine, as well as
Jussieu, heard the same statements, which appear to have been generally
prevalent at the close of the 17th century.

It is noteworthy, on the other hand, that though the Peruvians
tenaciously adhere to their traditional customs, they make no use at
the present day of Cinchona bark, but actually regard its employment
with repugnance.

Humboldt[1296] declares that at Loxa the natives would rather die than
have recourse to what they consider so dangerous a remedy. Pöppig[1297]
(1830) found a strong prejudice to prevail among the people of Huanuco
against Cinchona as a remedy for fevers, and the same fact was observed
farther north by Spruce[1298] in 1861. The latter traveller narrates,
that it was impossible to convince the _cascarilleros_ of Ecuador that
their _Red Bark_ could be wanted for any other purpose than dyeing
cloth; and that even at Guayaquil there was a general dislike to the
use of quinine.

Markham[1299] notices the curious fact that the wallets of the native
itinerant doctors, who from father to son have plied their art since
the days of the Incas, never contain cinchona bark.

Although Peru was discovered in 1513, and submitted to the Spanish
yoke by the middle of the century, no mention has been found of the
febrifuge bark with which the name of the country is connected, earlier
than the commencement of the 17th century.

Joseph de Jussieu,[1300] who visited Loxa in 1739, relates that the use
of the remedy was first made known to a Jesuit missionary, who being
attacked by intermittent fever, was cured by the bark administered to
him by an Indian cacique at Malacotas, a village near Loxa. The date
of this event is not given. The same story is related of the Spanish
corregidor of Loxa, Don Juan Lopez Canizares, who is said to have been
cured of fever in 1630.

Eight years later, the wife of the viceroy of Peru, Luis Geronimo
Fernandez de Cabrera y Bobadilla, fourth count of Chinchon, having
been attacked with fever, the same corregidor of Loxa sent a packet
of powdered bark to her physician Juan de Vega, assuring him of its
efficacy in the treatment of “_tertiana_.” The drug fully bore out its
reputation, and the countess Ana was cured.[1301] Upon her recovery,
she caused to be collected large quantities of the bark, which she
used to give away to those sick of fever, so that the medicine came to
be called _Polvo de la Condesa_, i.e. _The Countess’ Powder_. It was
certainly known in Spain the following year (1639), when it was first
tried at Alcala de Henares near Madrid.[1302]

[1295] _Phil Trans._ xl. for 1737-38. 81.

[1296] _Der Gesellsch. naturf. Freunde zu Berlin Magaz._ i. (1807) 60.

[1297] _Reise in Chile, Peru_, etc. ii. (1836) 222.

[1298] Blue Book—_East India Chinchona Plant_, 1863. 74. 75.

[1299] _Travels in Peru and India_, 1862. 2.

[1300] Quoted by Weddell in his _Hist. des Quinquinas_, p. 15, from De
Jussieu’s unpublished MS.—The town of Loxa or Loja was founded by the
Spaniards in 1546.

[1301] The circumstances are fully narrated by La Condamine (_Mém. de
l’Acad. royale des Sciences_, année 1738). But the cure of the countess
was known in Europe much before this, for it is mentioned by Sebastiano
Bado in his _Anastasis, Corticis Peruviæ, seu Chinæ Chinæ defensio_
published at Genoa in 1663. When Bado wrote, it was a debated question
whether the bark was introduced to Europe by the count of Chinchon or
by the Jesuit Fathers.

[1302] Villerobel, quoted by Bado, _op. cit._ 202.

The introduction of Peruvian Bark into Europe is described by
Chifflet, physician to the archduke Leopold of Austria, viceroy of the
Netherlands and Burgundy, in his _Pulvis Febrifugus Orbis Americani
ventilatus_, published at Brussels in 1653 (or 1651?). He says that
among the wonders of the day, many reckon the tree growing in the
kingdom of Peru, which the Spaniards call _Polo de Calenturas_, i.e.
_Lignum febrium_. Its virtues reside chiefly in the bark, which is
known as _China febris_, and which taken in powder drives off the
febrile paroxysms. He further states, that during the last few years
the bark has been imported into Spain, and thence sent to the Jesuit
Cardinal Joannes de Lugo at Rome.[1303] Chifflet adds, that it has
been carried from Italy to Belgium by the Jesuit Fathers going to the
election of a general, but that it was also brought thither direct from
Peru by Michael Belga, who had resided some years at Lima.

Chifflet, though candidly admitting the efficacy of the new drug when
properly used, was not a strong advocate for it; and his publication
started an acrimonious controversy, in which Honoratius Faber, a Jesuit
(1655), Fonseca, physician to Pope Innocent X., Sebastiano Bado[1304]
of Genoa (1656 and 1663), and Sturm (1659) appeared in defence of the
febrifuge; while Plempius (1655), Glantz, an imperial physician of
Ratisbon (1653), Godoy, physician to the king of Spain (1653), René
Moreau (1655), Arbinet and others contended in an opposite sense.

From one of these disputants, Roland Sturm, a doctor of Louvain, who
wrote in 1659,[1305] we learn that four years previously, some of the
new febrifuge had been sent by the archduke Leopold to the Spanish
ambassador at the Hague, and that he (Sturm) had been required to
report upon it. He further states, that the medicine was known in
Brussels and Antwerp as _Pulvis Jesuiticus_, because the Jesuit Fathers
were in the habit of administering it gratis to indigent persons
suffering from quartan fever; but that it was more commonly called
_Pulvis Peruanus_ or _Peruvianam Febrifugum_. At Rome it bore the name
of _Pulvis eminentissimi Cardinalis de Lugo_, or _Pulvis patrum_; the
Jesuits at Rome received it from the establishments of their order
in Peru, and used to give it away to the poor in Cardinal de Lugo’s
palace. In 1658 Sturm saw 20 doses sent to Paris which cost 60 florins.
He gives a copy of the handbill[1306] of 1651 which the apothecaries of
Rome used to distribute with the costly powder.

[1303] The cardinal belonged to a family of Seville, which town had the
monopoly of the trade with America.

[1304] Bado in his _Anastasis_, lib. 3, quotes the opinion of many
persons as coinciding with his own.

[1305] _Febrifugi Peruviani Vindiciarum pars prior—Pulveris Historiam
complectens ejusque vires et proprietates ...exhibens_, Delphis, 1669.
12°.

[1306] It is in these words:—_Modo di adoprare la Corteccia chiamata
della Febre_.—Questa Corteccia si porta dal Regno di Peru, e si chiama
China, o vero China della febre, laquale si adopra per la febre
quartans, e terzana, che venga con freddo: s’adropra in questo modo,
cioè:

Se ne piglia dramme due, e si pista fina, con passarla per setaccio; e
tre hore prima incirca, che debba venir la febre si mette in infusione
in un bicchiero di vino bianco gagliardissimo, e quando il freddo
commincia à venire, ò si sente qualche minimo principio, si prende
tutta la presa preparata, e si mette il patiente in letto.

Avertasi, si potrà dare detta Corteccia nel modo sudetto nella febre
terzana, quando quella sia fermata in stato di molti giorni.

L’esperienza continua, hà liberata quasi tutti quelli, che l’hanno
presa, purgato prima bene il corpo, e per quattro giorni doppo non
pigliar’ niuna sorte di medicamento, ma auvertasi di non darla se
non con licenza delli Sig. Medici, acciò giudicano se sia in tempo à
proposito di pigliarla.

The drug began to be known in England about 1655.[1307] The _Mercurius
Politicus_ one of the earliest English newspapers, contains in several
of its numbers for 1658,[1308] a year remarkable for the prevalence
in England of an epidemic remittent fever, advertisements offering
for sale—“_the excellent powder known by the name of the Jesuit’s
Powder_”—brought over by James Thomson, merchant of Antwerp.

Brady, professor of physic at Cambridge, prescribed bark about this
time; and in 1660, Willis, a physician of great eminence, reported it
as coming into daily use. This is also evidenced, with regard to the
continent, by the pharmaceutical tariffs of the cities of Leipzig and
Frankfurt of the year 1669, where “_China Chinæ_” has a place. ⅛ of an
ounce (a “quint”) is quoted in the latter at 50 kreuzers (about 1s.
6d.), whereas the same quantity of opium is valued at 4 kreuzers,[1309]
camphor 2 kreuzers, balsam of Peru 8 kreuzers.

Among those who contributed powerfully to the diffusion of the new
medicine, was Robert Talbor _alias_ Tabor. In his “Pyretologia” (see
Appendix, T.) he by no means intimates that his method of cure depends
on the use of bark. On the contrary, he cautions his readers against
the dangerous effects of Jesuit’s Powder when administered by unskilful
persons, yet admits that, properly given, it is a “noble and safe
medicine.”

Talbor’s reputation increasing, he was appointed in 1678 physician in
ordinary to Charles II., and in 1679, the king being ill of tertian
fever at Windsor, Talbor cured him by his secret remedy.[1310] He
acquired similar favour in France, and upon Talbor’s death (1681),
Louis XIV. ordered the publication of his method of cure, which
accordingly appeared by Nicolas de Blegny, surgeon to the king.[1311]
This was immediately translated into English, under the title of _The
English Remedy: or, Talbor’s Wonderful Secret for Cureing of Agues and
Feavers.—Sold by the Author Sir Robert Talbor to the most Christian
King and since his Death, ordered by his Majesty to be published in
French, for the benefit of his subjects, and now translated into
English for Publick Good_ (Lond. 1682).

Cinchona bark was now accepted into the domain of regular medicine,
though its efficacy was by no means universally acknowledged. It first
appeared in the London Pharmacopœia in 1677, under the name of _Cortex
Peruanus_.

[1307] So says Sir G. Baker, who has traced the introduction of
Cinchona in a very able paper published in the _Medical Transactions_
of the College of Physicians of London, iii. (1785) 141-216.

[1308] Namely No. 422. June 24-July 1; No. 426. July 22-29; No. 439.
Oct. 21-28. No. 545. Dec. 9-16.—We have examined the copy at the
British Museum.

[1309] Ph. Journ. vi. (1876) 1022.

[1310] In the _Recueil_ for 1680, p. 275 (see appendix, Talbor) the
king is said to have had another attack of fever at Windsor, for which
he took “_du Quinquina préparé_,” which again cured him.

[1311] _Le Remède anglais pour la guérison des fièvres, publié par
ordre du Roy, avec les observations de Monsieur le premier Médecin de
sa Majesté, sur la composition, les vertus, et l’usage de ce remède_,
par Nicolas de Blegny, Chirurgien ordinaire du corps de Monsieur, et
Directeur de l’Académie des nouvelles découvertes de Médecine, Paris,
1682. 12°.

For the first accurate information on the botany of Cinchona, science
is indebted to the French.[1312]

Charles-Marie de la Condamine, while occupied in common with Bouguer
and Godin, as an astronomer from 1736 to 1743, in measuring the
arc of a degree near Quito, availed himself of the opportunity to
investigate the origin of the famous Peruvian Bark. On the 3rd and 4th
of February, 1737, he visited the Sierra de Cajanuma, 2½ leagues from
Loxa, and there collected specimens of the tree now known as _Cinchona
officinalis_ var. _a. Condaminea_. At that period the very large
trees had already become rare, but there were still specimens having
trunks thicker than a man’s body. Cajanuma was the home of the first
cinchona bark brought to Europe; and in early times it enjoyed such a
reputation, that certificates drawn up before a notary were provided as
proof that parcels of bark were the produce of that favoured locality.

Joseph de Jussieu, botanist to the French expedition with which
La Condamine was connected, gathered, near Loxa in 1739, a second
_Cinchona_ subsequently named by Vahl _C. pubescens_, a species of no
medicinal value.

In 1742 Linnæus established the genus _Cinchona_,[1313] and in 1753
first described the species _C. officinalis_, recently restored and
exactly characterized by Hooker, aided by specimens supplied to him by
Mr. Howard.

The cinchona trees were believed to be confined to the region around
Loxa, until 1752 when Miguel de Santisteban, superintendent of the mint
at Santa Fé, discovered some species in the neighbourhood of Popayan
and Pasto.

In 1761 José Celestino Mutis, physician to the Marquis de la Vega,
viceroy of New Granada, arrived at Carthagena from Cadiz, and
immediately set about collecting materials for writing a _Flora_ of
the country. This undertaking he carried on with untiring energy,
especially from the year 1782 until the end of his life in 1808,—first
for seven years at Real del Sapo and Mariquita at the foot of the
Cordillera de Quindiu, and subsequently at Santa Fé de Bogotá. Mutis
gave up his medical appointment in 1772, for the purpose of entering a
religious order, and ten years later was entrusted by the Government
with the establishment and direction of a large museum of natural
history, first at Mariquita, afterwards at Santa Fé.

A position similar to that of Mutis in New Granada had also been
conferred in 1777 on the botanists Hipolito Ruiz and José Pavon with
regard to southern Peru, whence originated the well-known _Flora
Peruviana et Chilensis_,[1314] as well as most important direct
contributions to our knowledge on the subject of Cinchona.

About the same time (1776), Renquizo (Renquifo or Renjifo) found
cinchona trees in the neighbourhood of Huanuco, in the central tract of
Peru, whereby the monopoly of the district of Loxa was soon broken up.

[1312] _Sur l’arbre de Quinquina_ par M. de la Condamine—_Mém. de
l’Académie royale des Sciences pour l’année 1738_. pp. 226-243, with
two plates.

[1313] Markham has vigorously contended that the name _Cinchona_ should
be altered to _Chinchona_ as better commemorating the countess of
Chinchon. But the inconvenience of changing so well-established a name
and its many derivatives, has out-weighed these considerations.—See
list of works relating to Cinchona at the end of the present article.

[1314] Published at Madrid, 1798-1802, in 4 volumes folio, with 425
plates.

Numerous and important quinological discoveries were subsequently made
by Mutis, or rather by his pupils Caldas, Zea, and Restrepo,[1315]
as well as on the other hand by Ruiz and Pavon, and their successors
Tafalla and Manzanilla. Mutis did not bring his labours to any definite
conclusion, and his extensive botanical collections and 5,000 coloured
drawings, were sent to Madrid only in 1817, and there remained in a
lamentable state of neglect.

Some of his observations first appeared in print in 1793-94, under
the title of _El Arcano de la Quina_ in the _Diario_, a local paper
of Santa Fé, and were reprinted at Madrid in 1828 by Don Manuel
Hernandez de Gregorio. The botanical descriptions of the cinchonas
of New Granada, forming the fourth part of the _Arcano_, remained
forgotten and lost to science until rescued by Markham and published
in 1867.[1316] The drawings belonging to the descriptions were
photographed and engraved a little later, and form part of Triana’s
_Nouvelles Etudes sur les Quinquinas_, which appeared in 1870.

The two Peruvian botanists succeeded somewhat better in securing
their results. Ruiz in 1792, in his _Quinologia_,[1317] and in 1801
conjointly with Pavon in a supplement thereto, brought together a
portion of their important labours relating to cinchona. But an
essential part called _Nueva Quinologia_,[1318] written between 1821
and 1826, remained unpublished; and after an oblivion of over thirty
years, it came by purchase into the hands of Mr. John Eliot Howard, who
published it, and with rare liberality enriched it with 27 magnificent
coloured plates, mostly taken from the very specimens of Pavon lying in
the herbarium of Madrid.

Between the pupils of Mutis on the one hand, and those of Ruiz and
Pavon on the other, there arose an acrimonious controversy regarding
their respective discoveries, which has been equitably summarized by
Triana in the work just mentioned.

=Production=—The hardships of bark-collecting in the primeval forests
of South America are of the severest kind, and undergone only by
the half-civilized Indians and people of mixed race, in the pay of
speculators or companies located in the towns. Those who are engaged
in the business, especially the collectors themselves, are called
_Cascarilleros_ or _Cascadores_, from the Spanish word _Cascara_, bark.
A major-domo at the head of the collectors directs the proceedings of
the several bands in the forest itself, where provisions and afterwards
the produce are stowed away in huts of slight construction.

Arrot in 1736, and Weddell and Karsten in our own day, have given from
personal observation a striking picture of these operations.

[1315] “ ... Mutis n’avait qu’une notion inexacte et confuse du genre
_Cinchona_ et de ses véritables caractères; c’est en définitive
qu’aucune de ses espèces, dans le sens strict du mot, n’a été reconnue
ni découverte par lui.”—Triana, _Nouv. Etudes_, p. 8.

[1316] Markham, _Chinchona Species of New Granada_, Lond. 1867.

[1317] _Quinologia, ó tratado de árbol de la Quina, ó Cascarilla_,
Madrid, 1792. 4°. pp. 103.

[1318] _Supplemento á la Quinologia_, Madrid, 1801. 4°. pp. 154.

The cascarillero having found his tree, has usually to free its stem
from the luxuriant climbing and parasitic plants with which it is
encircled. This done, he begins in most cases at once to remove, after
a previous beating, the sapless layer of outer bark. In order to detach
the valuable inner bark, longitudinal and transverse incisions are made
as high as can be reached on the stem. The tree is then felled, and the
peeling completed. In most cases, but especially if previously beaten,
the bark separates easily from the wood. In many localities it has to
be dried by a fire made on the floor of a hut, the bark being placed
on hurdles above,—a most imperfect arrangement. In Southern Peru and
Bolivia however, according to Weddell, even the thickest Calisaya bark
is dried in the sun without requiring the aid of the fire.

The thinner bark as it dries rolls up into tubes or quills called
_canutos_ or _canutillos_, while the pieces stripped from the trunks
are made to dry flat by being placed one upon another and loaded with
weights, and are then known as _plancha_ or _tabla_. The bark of the
root was formerly neglected, but is now in several instances brought
into the market.

After drying, the barks are either assorted, chiefly according to
size, or all are packed without distinction in sacks or bales. In some
places, as at Popayan, the bark is even _stamped_, in order to reduce
its bulk as much as possible. The dealers in the export towns enclose
the bark in _serons_[1319] of raw bullock-hide, which, contracting as
it dries, tightly compresses the contents (100 lb. or more) of the
package. In many places however wooden chests are used for the packing
of bark.

=Conveyance to the Coast and Commercial Statistics=—The ports to which
bark is conveyed for shipment to Europe are not very numerous.

Guayaquil on the Pacific coast is the most important for produce of
Ecuador. The quantity shipped thence in 1871 was 7,859 quintals.[1320]
Pitayo bark is largely exported from Buenaventura in the Bay of Choco
further north.

Payta, the most northerly port of Peru, and Callao, the port of Lima,
likewise export bark, the latter being the natural outlet for the barks
of Central Peru from Huanuco to Cusco.

Islay, and more particularly Arica, receive the valuable barks of
Carabaya and of the high valleys of Bolivia. In 1877 the export of
Arica was equal to 5100 cwt.

The barks of Peru and Bolivia find an exceptional outlet also by the
Amazon and its tributaries, and are shipped to Europe from port of
Brazil. Howard[1321] has given an interesting account of one of the
first attempts to utilize this eastern route, made by Senr. Pedro Rada
in 1868.

There is a large export of the barks of New Granada, principally from
Santa Marta, whence the shipments[1322] in 1871 were 3,415,149 lb.; and
in 1872, 2,758,991 lb. From the neighbouring port of Savanilla, which
represents the city of Barranquilla, the sea-terminus of the navigation
of the Magdalena, the export of bark in 1871 was 1,043,835 lb., value
£38,715;[1323] it amounted to 2 millions of kilogrammes in 1877. All
Columbia is stated, in 1877, to have shipped 3½ millions of kilogrammes
of bark; yet a good deal of the excellent barks of the Columbian State
of Santander, especially those of the neighbourhood of Bucaramanga,
find their way to Maracaibo, taking the name of that place.

[1319] From _zurrón_, the Spanish name for a pouch or game-bag.

[1320] _Consular Reports_, presented to Parliament, July 1872.

[1321] Seemann’s _Journ. of Bot._ vi. (1868) 323.

[1322] _Consular Reports_, August 1873. 743.

[1323] _Ibid._ August 1872.

Some Cinchona bark is also shipped from Venezuela by way of Puerto
Cabello.

The quantity of bark appearing in the _Annual Statement of Trade_
as “Peruvian Bark” imported into the United Kingdom in 1872, was
28,451 cwt., valued £285,620; of which 11,843 cwt. was shipped from
New Granada, 4,668 cwt. from Ecuador, and 5,829 cwt. from Peru, the
remainder being entered as from the ports of Chili, Brazil, Central
America and other countries. The imports into the United Kingdom in
1876 were 26,021 cwt., valued at £272,154.

=Cultivation=—The reckless system of bark-cutting in the forests of
South America, which has resulted in the utter extermination of the
tree from many localities, has aroused the attention of the Old World,
and has at length prompted serious efforts to cultivate the tree on a
large scale in other countries.

The idea of cultivating Cinchonas out of their native regions was
advanced by Ruiz in 1792, and by Fée of Strassburg in 1824.[1324]
Royle[1325] pointed out in 1839 that suitable localities for the
purpose might be found in the Neilgherry Hills and probably in many
other parts of India, and argued indefatigably in favour of the
introduction of the tree.

The subject was also urged in reference to Java in 1837 by Fritze,
director of medical affairs in that island; in 1846 by Miquel, and
subsequently by other Dutch botanists and chemists.[1326]

Living Cinchonas had been taken to Algeria as early as 1849, by the
intervention of the Jesuits of Cusco, but their cultivation met with no
success.

Weddell in 1848 brought cinchona seeds from South America to France,
and strenuously insisted on the importance of cultivating the plant.
His seeds, especially those of _C. Calisaya_, germinated at the Jardin
des Plantes in Paris, and in June 1850, living seedlings were sent to
Algeria; and in April 1852, through the Dutch Government, to Java.

The first important attempts at cinchona cultivation were made by the
Dutch. Under the auspices of the Colonial Minister Pahud, afterwards
Governor-General of the Dutch East Indies, the botanist Hasskarl was
despatched to Peru for the purpose of obtaining seeds and plants. His
mission was so far successful, that a collection of plants contained in
21 Wardian cases, was shipped in August 1854 from Callao, in a frigate
sent expressly to receive them. Notwithstanding every care, the plants
did not reach Java in good condition; and when Hasskarl resigned his
appointment in 1856, he bequeathed to his successor Junghuhn only 167
young cinchonas, though 400 specimens had been shipped from South
America.

[1324] _Cours d’Hist. nat. pharmaceutique_, ii. (1828) 252.

[1325] _Illustrations of the Bot. of the Himalayan Mountains_, i.
(1839) 240.

[1326] According to K. W. van Gorkom, suggestions to the same end were
made to the Dutch Government as early as 1829 by Reinwardt.

An impulse to the project of cinchona-planting was given in 1852 by
Royle, in a report addressed to the East India Company, in which he
pointed out that the Government of India were then spending more than
£7,000 a year for Cinchona bark, in addition to about £25,000 for
quinine.[1327]

After some unsatisfactory endeavours on the part of the British
Government to obtain plants and seeds through the intervention of H.
M. Consuls in South America, Mr. Markham offered his services, which
were accepted. Markham, though not a professed botanist, was well
qualified for the task by a previous acquaintance with the country
and people of Peru and Bolivia, and by a knowledge of the Spanish
and Quichua languages,—and even more so by a rare amount of zeal,
intelligence, and forethought. Being fully aware of the difficulties of
the undertaking, he earnestly insisted that nothing should be neglected
which could ensure success; and in particular made repeated demands
for a steam-vessel to convey the young plants across the Pacific to
India, which unfortunately were not complied with. He further urged the
desirableness of not confining operations to a single district, but of
endeavouring to procure by different collectors all the more valuable
species.

The prudence of this latter suggestion was evident, and Markham was
enabled to engage the services of Richard Spruce, the distinguished
botanist, then resident in Ecuador, who expressed his readiness
to undertake a search for the Red Bark trees (_C. succirubra_) in
the forests of Chimborazo. He also secured the co-operation of G.
J. Pritchett for the neighbourhood of Huanuco, and of two skilful
gardeners, John Weir and Robert Cross. The last named was employed in
1861 to procure seeds of _C. officinalis_ from the Sierra de Cajanuma
near Loxa, and in 1868-64 those of _C. pitayensis_ from the province of
Pitayo in Ecuador.[1328]

Markham reserved for himself the border-lands of Peru and Bolivia, in
order to obtain _C. Calisaya_; and for this purpose started from Islay
in March 1860. Arriving in the middle of April by way of Arequipa and
Puno, at Curcero, the capital of the province of Carabaya, he made
his way to the village of Sandia, near which he met with the first
specimens of _Cinchona_ in the form of the shrubby variety of _C.
Calisaya_, termed _Josephiana_. He afterwards found the better variety
_a. vera_, and also _C. ovata_ R. et P., _C. micrantha_ R. et P., and
_C. pubescens_ Vahl. Of these sorts, but chiefly of the first three,
456 plants were shipped at Islay in June 1860.

In consequence of the hostile attitude of the people, and the jealousy
of the Bolivian Government, lest an important monopoly should be broken
up, added to the difficulties arising from insalubrious climate and the
want of roads, the obstacles encountered by Markham were very great,
and no attempt could be made to wait for the ripening of the seeds of
the Calisaya, which takes place in the month of August.[1329]

[1327] In 1870, the Indian Government purchased no less than 81,600
ounces of sulphate of quinine, besides 8,832 ounces of the sulphates
of cinchonine, cinchonidine and quinidine. The quantities bought in
subsequent years have been much smaller until the present year (1874).

[1328] _Report on the Expedition to procure seeds of C. Condaminea_
(1862); also _Report to the Under Secretary of State for India on the
Pitayo Chinchona_, by Robt. Cross, 1865.

[1329] Great difficulty was at first experienced in successfully
conveying living Cinchona plants to India, even in Wardian cases; and
the collections formed by Hasskarl, Markham, and Pritchett almost all
perished after reaching their destination (Markham’s letter, 26 Feb.
1861). But the propagation by seed has proved very rapid.

The expedition of Spruce was successful, but was also attended with
much difficulty and danger, of which there are vivid pictures in the
interesting narratives by himself and by Cross, published in the
Parliamentary Returns of 1863 and 1866.[1330]

The service entrusted, to Pritchett was also efficiently performed; and
he succeeded in bringing to Southampton six cases containing plants of
_C. micrantha_ and _C. nitida_, besides a large supply of seeds.

Some important supplies of plants and seed for British India have
likewise been obtained from the Dutch plantations in Java. Seeds of _C.
lancifolia_, the tree affording the valuable bark of New Granada, were
procured through Dr. Karsten.

Previously to the arrival in India of the first consignment of plants,
careful inquiries were instituted from a meteorological and geological
point of view, as to the localities most adapted for the cultivation.
This resulted in the selection for the first trial of certain spots
among the Neilgherry (or Nilgiri) Hills on the south-west coast of
India and in the Madras Presidency. Of this district, the chief town
is Ootocamund (or Utakamand), situated about 60 miles south of Mysore
and the same distance from the Indian Ocean. Here the first plantation
was established in a woody ravine, 7,000 feet above the sea-level, a
spot pronounced by Mr. Markham to be exceedingly analogous, as respects
vegetation and climate, to the Cinchona valleys of Carabaya. Other
plantations were formed in the same neighbourhood, and so rapid was the
propagation, that in September 1866, there were more than 1½ millions
of Cinchona plants on the Neilgherry Hills alone.[1331] The species
that grows best there is _C. officinalis_.

The number was stated to be in 1872, 2,639,285, not counting the trees
of private planters. The largest are about 30 feet high, with trunks
over 3 feet in girth. The area of the Government plantations on the
Neilgherry Hills is 950 acres.[1332]

Plantations have also been made in the coffee-producing districts of
Wynaad, and in Coorg, Travancore and Tinnevelly, in all instances, we
believe, as private speculations.

Cinchona plantations have been established by the Government of India
in the valleys of the Himalaya in British Sikkim,[1333] and some have
been started in the same region by private enterprise. In the former
there were on the 31st March 1870, more than 1½ millions of plants
permanently placed, the species growing best being _C. succirubra_
and _C. Calisaya_. The Cinchona plantation of Rungbi near Darjiling
(British Sikkim) covered in 1872 2,000 acres. In the Kangra valley of
the Western Himalaya, plantations have been commenced, as well as in
the Bombay Presidency, and in British Burma.

[1330] _Correspondence relating to the introduction of the Chinchona
Plant into India_, ordered by the House of Commons to be printed 20
March 1863 and 18 June 1866.

[1331] Blue Book (Chinchona Cultivation, 1870. p. 30).—A name that must
always be remembered in connection with the Neilgherry plantations,
is that of William Graham McIvor, who by his rare practical skill and
sagacity in the cultivation and management of the tree, has rendered
most signal services in its propagation in India.

[1332] _Moral and material progress and condition of India during
1871-72_, presented to Parliament 1873. p. 33.

[1333] The first annual Report dates from 1862 to 1863; I am indebted
to Dr. King for that of 1876-1877.—F. A. F.

Ceylon offers favourable spots for the cultivation of Cinchona, in
the mountain region which occupies the centre of the island, as
at Hakgalle, near Neuera-Ellia, 5,000 feet above the sea, where a
plantation was formed by Government in 1861. The production of bark has
been taken up with spirit by the coffee-planters of Ceylon.

The Government of India has acted with the greatest liberality in
distributing plants and seeds of Cinchona, and in promoting the
cultivation of the tree among the people of India; and it has freely
granted supplies of seed to other countries.

The plantations of Java commenced by Hasskarl, increased under
Junghuhn’s management to such an extent, that in December 1862 there
were 1,360,000 seedlings and young trees, among which however the more
valuable species, as _C. Calisaya_, _C. lancifolia_, _C. micrantha_
and _C. succirubra_, were by far the least numerous, whereas _C.
Pahudiana_, of which the utility was by no means well established,
amounted to over a million. The disproportionate multiplication of this
last was chiefly due to its quickly yielding an abundance of seeds, and
to its rapid and vigorous growth. Another defect in the early Dutch
System of cultivation arose from the notion that the Cinchona requires
to be grown in the shade of other trees, and to a less successful plan
of multiplying by cuttings and layers.

These and other matters were the source of animated and often bitter
discussions, which terminated on the one hand by the death of Junghuhn
in 1864, and on the other by the skilful investigations of De Vry. This
eminent chemist was despatched by the Government of Holland in 1857 to
Java, that he might devote his chemical knowledge to the investigation
of the natural productions of the island, including the then newly
introduced Cinchona. It was March 16th, 1859, when Dr. de Vry laid
before the governor-general, Mr. Pahud, the first crystals of sulphate
of quinine he had prepared from bark grown in that island.

Under K. W. van Gorkom, who was appointed superintendent in 1864, the
Dutch plantations have assumed a very prosperous state. J. C. Bernelot
Moens,[1334] the present director, stated that at the end of 1878 the
leading species was Calisaya in its various forms, including more than
400,000 plants of Ledger’s Calisaya. Numerous analyses of Bernelot
Moens show a percentage of from 4½ to 10·6 of quinine in the latter
variety. Some of them, however, in December 1878, afforded not more
than 0·64 per cent. of quinine and 1·26 of cinchonidine.

The regular shipments of the barks from Java to the Amsterdam market
are going on, and the barks are sold there with regard to the results
of the government chemist’s analyses.

Cinchona Bark from the Indian plantations began to be brought into the
London market in 1867,[1335] and now arrives in constantly increasing
quantities.

The history of the transplantation of the Cinchona down to the year
1867 has been made the subject of the report of Soubeiran and Delondre
mentioned at the end of the present article.

[1334] I am indebted to the Dutch administration for their interesting
statistical documents relating to Cinchona.—F. A. F.

[1335] When I was in London, in August 1867, I went to Finsbury Place,
to meet Mr. Spruce, and was happy enough to find there also Mr. Howard,
who presented Mr. S. and myself with market samples of the _first_
importation of _C. succirubra_, from Denison plantation, Ootacamund.—F.
A. F.

=Description=—(=A.=) _Of Cinchona Barks generally_—In the development
of their bark, the various species of Cinchona exhibit considerable
diversity. Many are distinguished from an early stage by an abundant
exfoliation of the outer surface, while in others this takes place
to a smaller degree, or only as the bark becomes old. The external
appearance of the bark varies therefore very much, by reason of the
greater or less development of the suberous coat. The barks of young
stems and branches have a greyish tint more or less intense, while the
outer bark of old wood displays the more characteristic shades of brown
or red, especially after removal of the corky layers.

In the living bark, these colours are very pale, and only acquire their
final hue by exposure to the air, and drying. Some of them however are
characteristic of individual species, or at least of certain groups,
so that the distinctions originated by the bark-collectors of _pale_,
_yellow_, _red_, etc.[1336] and adopted by druggists, are not without
reason.

In texture, the barks vary in an important manner by reason of
diversity in anatomical structure. Their fracture especially depends
upon the number, size, and arrangement of the liber-fibres, as will be
shown in our description of their microscopic characters.

The taste in all species is bitter and disagreeable, and in some there
is in addition a decided astringency. Most species have no marked
odour, at least in the dried state. But this is not the case in that of
_C. officinalis_, the smell of which is characteristic.

(=B.=) _Of the Barks used in pharmacy_—For pharmaceutical preparations
as distinguished from the pure alkaloids and their salts, the Cinchona
barks employed are chiefly of three kinds.

1. _Pale Cinchona Bark_, _Loxa Bark_, _Crown Bark_[1337]—This bark,
which previous to the use of Quinine and for long afterwards, was the
ordinary _Peruvian Bark_ of English medicine, is only found in the
form of quills, which are occasionally as much as a foot in length,
but are more often only a few inches or are reduced to still smaller
fragments. The quills are from ¾ down to an ⅛ of an inch in diameter,
often double, and variously twisted and shrunken. The thinnest bark
is scarcely stouter than writing paper; the thickest may be ⅒ of an
inch or more.[1338] The pieces have a blackish brown or dark greyish
external surface, variously blotched with silver-grey, and often beset
with large and beautiful lichens. The surface of some of the quills
is longitudinally wrinkled and moderately smooth; but in the majority
it is distinctly marked by transverse cracks, and is rough and harsh
to the touch. The inner side is closely striated and of a bright
yellowish-brown.

The bark breaks easily with a fracture which exhibits very short fibres
on the inner side. It has a well-marked odour _sui generis_, and an
astringent bitter taste. Though chiefly afforded by _C. officinalis_,
some other species occasionally contribute to furnish the Loxa Bark of
commerce as shown in the conspectus at p. 355.

[1336] The following are common terms in reference to the barks of
Peru:—_Amarilla_ (yellow), _blanca_ (white), _colorado_ or _roja_
(red), _naranjada_ (orange), _negrilla_ (brown).

[1337] _Cortex Cinchonæ pallidæ_; F. _Quinquina Loxa_; G. _Loxachina_.
The term _Crown Bark_ was originally restricted to a superior sort of
Loxa Bark, shipped for the use of the royal family of Spain.

[1338] In the old collections of the Royal College of Physicians, there
are specimens of very thick Loxa Bark, of a quality quite unknown there
at the present day. They are doubtless the produce of ancient trees,
such as were noticed by La Condamine.

2. _Calisaya Bark_, _Yellow Cinchona Bark_.[1339]—This bark, which is
the most important of those commonly used in medicine, is found in flat
pieces (α.), and in quills (β.), both afforded by _C. Calisaya_ Wedd.,
though usually imported separated.

α. _Flat Calisaya_—is in irregular flat pieces, a foot or more in
length by 3 to 4 inches wide, but usually smaller, and ²/₁₀ to ⁴/₁₀ of
an inch in thickness; devoid of suberous layers and consisting almost
solely of liber, of uniform texture, compact and ponderous. Its colour
is a rusty orange-brown, with darker stains on the outer surface. The
latter is roughened with shallow longitudinal depressions, sometimes
called _digital furrows_.[1340] The inner side has a wavy, close,
fibrous texture. The bark breaks transversely with a fibrous fracture;
the fibres of the broken ends are very short, easily detached, and with
a lens are seen to be many of them faintly yellowish and translucent.

A well-marked variety, known as _Bolivian Calisaya_, is distinguished
for its greater thinness, closer texture, and for containing numerous
laticiferous ducts which are wanting in common flat Calisaya bark.

β. _Quill Calisaya_—is found in tubes ¾ to 1½ inch thick, often rolled
up at both edges, thus forming double quills. They are always coated
with a thick, rugged, corky layer, marked with deep longitudinal and
transverse cracks, the edges of which are somewhat elevated. This
suberous coat, which is silvery white or greyish, is easily detached,
leaving its impression on the cinnamon-brown middle layer. The inner
side is dark brown and finely fibrous. The transverse fracture is
fibrous but very short. The same bark also occurs in quills of very
small size, and is then not distinguishable with certainty from Loxa
bark.

3. _Red Cinchona Bark._—Though still retaining a place in the British
Pharmacopœia, this is by far the least important of the Cinchona barks
employed in pharmacy. But as the tree yielding it (_C. succirubra_) is
now being cultivated on a large scale in India, the bark may probably
come more freely into use.

Red Bark of large stems, which is the most esteemed kind, occurs in
the form of flat or channelled pieces, sometimes as much as ½ an inch
in thickness, coated with their suberous envelope which is rugged and
warty. Its outermost layer in the young bark has a silvery appearance.
The inner surface is close and fibrous and of a brick-red hue. The bark
breaks with a short fibrous fracture.[1341]

(=C.=) _Of the Barks not used in pharmacy_—Among the non-officinal
barks, the most important are afforded by _Cinchona lancifolia_ Mutis
and _C. pitayensis_ Wedd., natives of the Cordilleras of Columbia.

These barks are largely imported and used for making quinine, the
former under the name of _Columbian_, _Carthagena_, or _Caqueta bark_.
It varies much in appearance, but is generally of an orange-brown;
the corky coat, which scales off easily, is shining and whitish. The
barks of _C. lancifolia_ often occur in fine large quills or thick
flattish pieces. Their anatomical structure agrees in all varieties
which we have examined, in the remarkable number of thick-walled and
tangentially-extended cells of the middle cortical layer and the
medullary rays. In percentage of alkaloids, Carthagena barks are liable
to great variation.

[1339] _Cortex Cinchonæ flavæ_, _Cortex Chinæ regius_; F. _Quinquina
Calisaya_; G. _Königschina_.

[1340] From the notion that they resemble the marks left by drawing the
fingers over wet clay.

[1341] Thick Red Bark that happens to have a very deep and brilliant
tint is eagerly bought at a high price for the Paris market.

The _Pitayo Barks_ are restricted to the south-western districts of
Columbia,[1342] and are usually imported in short flattish fragments,
or broken quills, of brownish rather than orange colour, mostly covered
with a dull greyish or internally reddish cork. The middle cortical
layer exhibits but few thick-walled cells; the liber is traversed by
very wide medullary rays, and is provided with but a small number of
widely scattered liber-fibres, which are rather thinner than in most
other Cinchona barks. The Pitayo barks are usually rich in alkaloids,
quinine prevailing. _Cinchona pitayensis_ is one of the hardiest
species of the valuable Cinchonas, and is therefore particularly
suitable for cultivation, which however has not yet been carried out as
largely as that of either _C. officinalis_ or _C. succirubra_.

In the Conspectus on the next page, we have arranged the principal
species of _Cinchona_, with short indications of the barks which some
of them afford.[1343]

=Microscopic Structure=—The first examination of the minute structure
of Cinchona barks is due to Weddell, whose observations have been
recorded in one of his beautiful plates published in 1849.[1344] Since
that time numerous other observers have laboured in the same field of
research.

_General Characters._—These barks, as contrasted with those of other
trees, do not exhibit any great peculiarities of structure; and
their features may be comprehended in the following statements. The
_epidermis_, in the anatomical sense, occurs only in the youngest
barks, which are not found in commerce. The _corky layer_, which
replaces the epidermis, is constructed of the usual tabular cells. In
some species as _C. Calisaya_, it separates easily, at least in the
older bark, whereas in others as _C. succirubra_, the bark even of
trunks is always coated with it. In several species the corky tissue is
not only found on the surface, but strips of it occur also in the inner
substance of the bark. In this case the portions of tissue external
to the inner corky layers or bands are thrown off as _bork-scales_
(_periderm_ of Weddell). This peculiar form of suberous tissue[1345]
was first examined (not in cinchona) in 1845 by H. von Mohl, who called
it _rhytidoma_ (_Borke_ of the Germans). In _C. Calisaya_ it is of
constant occurrence, but not so usually in _C. succirubra_ and some
others; the rhytidoma therefore affords a good means of distinguishing
several barks.

The inner portion of the bark exhibits a _middle_ or _primary layer_
(_mesophlœum_),[1346] made up of parenchyme; and a second inner layer
or _liber_ (_endophlœum_)[1347] displaying a much more complicated
structure. The primary layer disappears if rhytidoma is formed: barks
in which this is the case are therefore at last exclusively composed of
liber, of which Flat Calisaya Bark is a good example.

[1342] Pitayo is an Indian village eastward of Popayan; see map of the
country between Pasto and Bogotá in Blue Book (East India Chinchona
Plant) 1866. 257.

[1343] Two species included by Weddell in his _Notes sur les
Quinquinas_, namely _C. Chomeliana_ Wedd. and _C. barbacoensis_ Karst.,
have been omitted, as not in our opinion belonging to the genus.

[1344] _Hist. nat. des Quinquinas_, tab. ii.

[1345] Flückiger, _Grundlagen_, Berlin, 1872. 61. fig. 48.

[1346] _Enveloppe ou tunique cellulaire_ of Weddell; _Mittelrinde_ of
the Germans.

[1347] In German _Bast_, or _Phloëm_ of modern German botany.

                 CONSPECTUS OF THE PRINCIPAL SPECIES OF CINCHONA.

  ---------------------------------+----------------+-------------+------
   SPECIES (EXCLUDING SUB-SPECIES  |                |             | WHERE
           AND VARIETIES)          | WHERE FIGURED. |   NATIVE    | CULTI-
        ACCORDING TO WEDDELL.      |                |  COUNTRY.   | VATED.
  ---------------------------------+----------------+-------------+-------
  I. Stirps Cinchonæ officinalis   |                |             |
     1. Cinchona officinalis Hook  |Bot. Mag. 5804  |Ecuador      |India,
                                   |                | (Loxa)      |Ceylon,
                                   |                |             |Java.
     2.   ”  macrocalyx Pav.       |Howard N. Q.    |Peru         |
                                   |                |             |
     3.   ”  lucumæfolia Pav.      |  Do.           |Ecuador,     |
                                   |                |Peru.        |
     4.   ”  lanceolata R. et P.(?)|  Do.           |Peru         |
     5.   ”  lancifolia Mutis      |Karsten tab. 11.|New Granada  |India
                                   |             12.|             |
     6.   ”  amygdalifolia Wedd.   |Wedd. tab. 6.   |Peru, Bolivia|
                                   |                |             |
  II. Stirps Cinchonæ rugosæ       |                |             |
     7. Cinchona pitayensis Wedd.  |Karst. tab. 22. |New Granada  |India
                                   |(C. Trianæ).    |(Popayan)    |
     8.   ”  rugosa Pav.           |Howard N. Q.    |Peru         |
     9.   ”  Mutisii Lamb.         |  Do.           |Ecuador      |
    10.   ”  hirsuta R. et P.      |Wedd. tab. 21.  |Peru         |
    11.   ”  carabayensis Wedd.    |Wedd. tab. 19.  |Peru, Bolivia|
    12.   ”  Pahudiana How.        |Howard N. Q.    |Peru         |India,
                                   |                |             |Java
    13.   ”  asperifolia Wedd.     |Wedd. tab. 20.  |Bolivia      |
    14.   ”  umbellulifera Pav.    |Howard N. Q.    |Peru         |
    15.   ”  glandulifera R. et P. |  Do.           |Peru         |
    16.   ”  Humboldtiana Lamb.    |  Do.           |Peru         |
                                   |                |             |
  III. Stirps Cinchonæ micranthæ   |                |             |
    17. Cinchona australis Wedd.   |Wedd. tab. 8.   |South Bolivia|
    18.   ”  scrobiculata H. et B. |  Do.           |Peru         |
    19.   ”  peruviana How.        |Howard N. Q.    |Peru         |India
    20.   ”  nitida R. et P.       |  Do.           |Peru         |India
    21.   ”  micrantha R. et P.    |  Do.           |Peru         |India
                                   |                |             |
  IV. Stirps Cinchonæ Calisayæ     |                |             |
    22. Cinchona Calisaya Wedd.    |Wedd. tab. 9.   |Peru, Bolivia|India,
                                   |                |             |Ceylon,
                                   |                |             |Java,
                                   |                |             |Jamaica,
                                   |                |             |Mexico.
    23.   ”  elliptica Wedd.       |                |Peru         |
                                   |                | (Carabaya)  |
                                   |                |             |
  V. Stirps Cinchonæ ovatæ         |                |             |
    24. Cinchona purpurea R. et P. |Howard N. Q.    |Peru         |
                                   |                | (Huamalica) |
    25.   ”  rufinervis Wedd.      |  Do.           |Peru,        |
                                   |                |Bolivia      |
    26.   ”  succirubra Pav.       |  Do.           |Ecuador      |India,
                                   |                |             |Ceylon,
                                   |                |             |Java,
                                   |                |             |Jamaica.
    27.   ”  ovata R. et P.        |  Do.           |Peru,        |India(?),
                                   |                |Bolivia      |Java(?)
    28.   ”  cordifolia Mutis      |Karsten tab. 8. |New Granada, |
                                   |                |Peru         |
                                   |                |             |
    29.   ”  tucujensis Karst.     |Karsten tab. 9. |Venezuela    |
    30.   ”  pubescens Vahl        |Wedd. tab. 16.  |Ecuador,     |
                                   |                | Peru,       |
                                   |                |Bolivia      |
                                   |                |             |
    31.   ”  purpurascens Wedd.    |Wedd. tab. 18   |Bolivia      |
  ---------------------------------+----------------+-------------+

  ---------------------------------+------------------------------------
   SPECIES (EXCLUDING SUB-SPECIES  |
           AND VARIETIES)          |             PRODUCT
        ACCORDING TO WEDDELL.      |
  ---------------------------------+------------------------------------
  I. Stirps Cinchonæ officinalis   |
     1. Cinchona officinalis Hook  | Loxa or Crown Bark, Pale Bark.
                                   |
     2.   ”  macrocalyx Pav.       | Ashy Crown Bark. The sub-species
                                   | _C. Palton_ affords an important
                                   | sort called _Palton Bark_ much
                                   | used in the manufacture of quinine.
     3.   ”  lucumæfolia Pav.      |
                                   |
     4.   ”  lanceolata R. et P.(?)| Carthagena Bark, confounded with
                                   | Palton Bark, but is not so good.
     5.   ”  lancifolia Mutis      | Columbian Bark. Imported in large
                                   | quantities for manufacture of
                                   | quinine.The soft Columbian Bark is
                                   | produced by Howard’s var.
                                   | _oblonga_.
                                   |
     6.   ”  amygdalifolia Wedd.   | A poor bark, but not now imported.
                                   |
  II. Stirps Cinchonæ rugosæ       |
     7. Cinchona pitayensis Wedd.  | Pitayo Bark. Very valuable; used by
                                   | makers of quinine; it is the chief
                                   | source of quinidine.
                                   |
     8.   ”  rugosa Pav.           | Bark unknown, probably valueless.
     9.   ”  Mutisii Lamb.         | Bark not in commerce, contains only
                                   | aricine.
    10.   ”  hirsuta R. et P.      |
    11.   ”  carabayensis Wedd.    | Bark not collected.
    12.   ”  Pahudiana How.        | A poor bark, yet of handsome
                                   | appearance; propagation of tree
                                   | discontinued.
                                   |
    13.   ”  asperifolia Wedd.     | Bark not collected.
    14.   ”  umbellulifera Pav.    | Bark not known as a distinct sort.
    15.   ”  glandulifera R. et P. |   Do.
    16.   ”  Humboldtiana Lamb.    | False Loxa Bark, Jaen Bark. A very
                                   | bad bark.
                                   |
  III. Stirps Cinchonæ micranthæ   |
    17. Cinchona australis Wedd.   | An inferior bark, mixed with
                                   | Calisaya.
    18.   ”  scrobiculata H. et B. | Bark formerly known as _Red
                                   | Cusco Bark_ or _Santa Ana Bark_.
    19.   ”  peruviana How.        |
    20.   ”  nitida R. et P.       | Grey Bark, Huanuco or Lima Bark.
                                   | Chiefly consumed on the Continent.
    21.   ”  micrantha R. et P.    |
                                   |
  IV. Stirps Cinchonæ Calisayæ     |
    22. Cinchona Calisaya Wedd.    | Calisaya Bark, Bolivian Bark,
                                   | Yellow Bark. The tree exists under
                                   | many varieties, bark also very
                                   | variable.
                                   |
    23.   ”  elliptica Wedd.       | Carabaya Bark. Bark scarcely now
                                   | imported. _C. sunsura_ Miq.
                                   | (flower and fruit unknown)
                                   | may perhaps be this species.
                                   |
  V. Stirps Cinchonæ ovatæ         |
    24. Cinchona purpurea R. et P. | Huamalies Bark. Not now Imported.
                                   |
    25.   ”  rufinervis Wedd.      | Bark, a kind of light Calisaya.
                                   |
    26.   ”  succirubra Pav.       | Red Bark. Largely cultivated in
                                   | British India.
                                   |
    27.   ”  ovata R. et P.        | Inferior Brown and Grey Barks.
                                   |
    28.   ”  cordifolia Mutis      | Columbian Bark (in part). Tree
                                   | exists under many varieties; bark
                                   | of some used in manufacture of
                                   | quinine.
                                   |
    29.   ”  tucujensis Karst.     | Maracaibo Bark.
                                   |
    30.   ”  pubescens Vahl        | Arica Bark (Cusco Bark from var.
                                   | _Pelletieriana_). Some of the
                                   | varieties contain aricine.
                                   | _C. caloptera_ Miq. is probably
                                   | a var. of this species.
                                   |
    31.   ”  purpurascens Wedd.    | Bark unknown in commerce.
  ---------------------------------+-----------------------------------------

The liber is traversed by _medullary rays_, which in cinchona are
mostly very obvious, and project more or less distinctly into the
middle cortical tissue. The liber is separated by the medullary rays
into wedges,[1348] which are constituted of a parenchymatous part and
of yellow or orange fibres. The number, colour, shape, and size, but
chiefly the arrangement of these fibres, confer a certain character
common to all the barks of the group under consideration.

The liber-fibres[1349] are elongated and bluntly pointed at their ends,
but never branched, mostly spindle-shaped, straight or slightly curved,
and not exceeding in length 3 millimetres. They are consequently of
a simpler structure than the analogous cells of most other officinal
barks. They are about ¼ to ⅓ mm. thick, their transverse section
exhibiting a quadrangular rather than a circular outline. Their walls
are strongly thickened by numerous secondary deposits, the cavity
being reduced to a narrow cleft, a structure which explains the
brittleness of the fibres. The liber-fibres are either irregularly
scattered in the liber-rays, or they form radial lines transversely
intersected by narrow strips of parenchyme, or they are densely packed
in short bundles. It is a peculiarity of cinchona barks that these
bundles consist always of a few fibres (3 to 5 or 7), whereas in many
other barks (as cinnamon) analogous bundles are made up of a large
number of fibres. Barks provided with long bundles of the latter kind
acquire therefrom a very fibrous fracture, whilst cinchona barks from
their short and simple fibres exhibit a short fracture. It is rather
granular in Calisaya bark, in which the fibres are almost isolated by
parenchymatous tissue. In the bark of _C. scrobiculata_, a somewhat
short fibrous fracture[1350] is due to the arrangement of the fibres
in radial rows. In _C. pubescens_, the fibres are in short bundles and
produce a rather woody fracture.

Besides the liber-fibres, there are some other cells contributing to
the peculiarity of individual cinchona barks. This applies chiefly to
the _laticiferous ducts_ or _vessels_[1351] which are found in many
sorts; they are scattered through the tissue intervening between the
middle cortical layer and the liber, and consist of soft, elongated,
unbranched cells, mostly exceeding in diameter the neighbouring
parenchymatous cells.

As to the _contents of the tissue_ of cinchona barks, crystallized
alkaloids are not visible. Howard has published figures representing
minute rounded aggregations of crystalline matter in the cells, which
he supposes to be kinovates of the alkaloids; and also distinct
acicular crystals which he holds to be of the same nature. These
remarkable appearances are easily observable, yet only after sections
of the bark have been boiled for a minute in weak caustic alkali
and then washed with water; it may well be doubted whether they are
strictly natural. The liquids which are capable of dissolving the
alkaloids in the free state do not afford any if they are applied to
the barks. The alkaloids being contained in the bark in the form of
salts, the latter are decomposed by caustic lye, and the alkaloids set
at liberty assume the crystallized state. This is in our opinion the
origin of the crystals under notice.

[1348] _Baststrahlen_ or _Phloëmstrahlen_ of the Germans.

[1349] _Fibres corticales_ of Weddell; _Baströhren_ or _Bastzellen_ in
German.

[1350] _Fracture filandreuse_, Weddel; _fädiger Bruch_ of the Germans.

[1351] _Vaisseaux laticifères_ of Weddell; _Milchsaftschläuche_ in
German.

The greater number of the parenchymatous cells are loaded with small
starch granules, or in young and fresh barks with chlorophyll. In
several barks, as in that of _C. lancifolia_ Mutis, numerous cells of
the middle cortical layer and even of the medullary rays, are provided
with somewhat thick walls, and contain either a soft brown mass or
crystalline oxalate of calcium. These cells have therefore been called
_resin-cells_ and _crystal-cells_; they are mostly isolated, not
forming extensive groups or zones, and their walls are not strongly
thickened as in true sclerenchymatous tissue. If thin sections of
the barks are moistened with dilute alcoholic perchloride of iron,
the walls of the cells, except the fibres and the cork, assume a
blackish-green due to cincho-tannic acid; this applies even to the
starch granules.

_Characters of particular sorts._—The modifications of general
structure just described, are sufficient to impart a special character
to the bark of many species of Cinchona, provided the bark is examined
at its full development, the structural peculiarities being far from
well-marked in young barks.

Thus it is not possible to point out any distinctive features for
the _Loxa Bark_ of commerce, because it is mostly taken from young
wood. We may say of it, that neither resin-cells nor crystal-cells
occur in its middle layer, that its laticiferous vessels become soon
obliterated, and have indeed disappeared in the older quills; and that
the liber-fibres form interrupted, not very regular, radial rows.

The quills of _C. Calisaya_ display large laticiferous ducts, which
are wanting in the flat bark. There is a peculiar sort of the latter
called _Bolivian Calisaya_ (already mentioned at p. 353), the flat
pieces of which still possess very obvious laticiferous vessels. As to
the liber-fibres of Calisaya bark, they are, as before stated (p. 356),
scattered throughout the parenchymatous tissue or endophlœum. In the
bark of _C. scrobiculata_, which might at first sight be confounded
with Calisaya bark, the liber-fibres form radial, less interrupted
rows. The microscope affords therefore the means of distinguishing
these two barks.

The barks of _C. succirubra_ are particularly rich in laticiferous
ducts, mostly of considerable diameter, in which the formation of new
parenchyme may not unfrequently be observed. The orange liber-fibres
occurring in this bark are less numerous, more scattered, and of
smaller size than in Calisaya. The fracture of Red Bark, especially the
flat sort, is therefore more finely granular and not so coarse as that
of Calisaya.

The structural characters of Cinchona barks may lastly be fully
appreciated by examining barks of the allied genera _Buena_,
_Cascarilla_ and _Ladenbergia_, which were formerly known under
the name of _False Cinchona Barks_. The microscope shows that the
liber-fibres of the latter are soft, branched and long, densely
packed into large bundles, imparting therefore a well-marked fibrous
structure. The external appearance of these barks is widely different
from that of true cinchona barks; none of them it would appear is now
collected for the purpose of adulteration.

=Chemical Composition=—The most important and at the same time
peculiar principles of Cinchona bark are the _Alkaloids_,—enumerated in
the following table:—[1352]

    Cinchonine                                    C₂₀H₂₄N₂O.
                or, as proposed by Skraup (1878)  C₁₉H₂₂N₂O.
    Cinchonidine (_Quinidine_ of many writers)    same formula.
    Quinine                                       C₂₀H₂₄N₂O₂.
    Quinidine (_Conquinine_ of Hesse)             same formula.
    Quinamine                                     C₁₉H₂₄N₂O₂.
    Conquinamine (_Conchinamine_)                 same formula.

B. A. Gomes[1353] of Lisbon (1810) first succeeded in obtaining active
principles of cinchona, by treating an alcoholic extract of the bark
with water, adding to the solution caustic potash, and crystallizing
the precipitate from alcohol. The basic properties of the substance
thus obtained, which Gomes called _Cinchonino_, were observed in the
laboratory of Thénard by Houtou-Labillardière, and communicated to
Pelletier and Caventou.[1354] Shortly before that time, Sertürner had
asserted the existence of organic alkalis: and the French chemists,
guided by that brilliant discovery, were enabled to show that the
_Cinchonino_ of Gomes belonged to the same class of substances.
Pelletier and Caventou, however, speedily pointed out that it consisted
of two distinct alkaloids, one of which they named _Quinine_, the
other _Cinchonine_. In 1827 the Institut de France awarded to the two
chemists for their discovery the Montyon prize of 10,000 francs (see
page 57, note 4).

[1352] Hesse, in 1877, pointed out the existence of a series of
new alkaloids existing in Cinchona. We refrain from repeating his
statements, which will be found abstracted in the _Yearbook of Pharm._
1878. 63.

[1353] Ensaio sobre o Cinchonino, e sobre sua influencia na virtude da
quina e d’outras cascas.—_Mem. da Acad. R. das Sciencias de Lisboa_,
iii. (1812) 202-217.

[1354] _Ann. de Chim. et de Phys._ xv. (1820) 292.

_Cinchonidine_ (thus called by Pasteur in 1853) was first obtained and
characterized under the name of _Quinidine_ in 1847, by F. L. Winckler
of Darmstadt, from Maracaibo Bark (_C. tucujensis_ Karst.); and in
1852 it was more closely studied by Leers, still under the name of
_quinidine_.

_Cinchovatine_, formerly stated to be a peculiar alkaloid, has been
shown by Hesse in 1876 to agree with cinchonidine.

_Quinidine_ is the name applied by Henry and Delondre to an alkaloid
they obtained in 1833; its peculiar nature was not clearly proved
until 1853, when Pasteur examined it, and 1857 when De Vry showed its
identity with the _Beta-quinine_ extracted in 1849 by Van Heijningnen
from commercial quinoidin. The name _quinidine_ having been since
applied to different basic substances more or less pure, Hesse (1865)
has proposed to replace it by that of _Conquinine_ (Conchinin in
German). The alkaloid is especially characteristic of the Pitayo barks,
and also occurs in the Calisaya barks from Java.

_Quinamine_ was discovered in 1872 by Hesse, in bark of _C. succirubra_
cultivated at Darjiling in British Sikkim; it is also of common
occurrence in the barks collected in Java. _Conquinamine_ was extracted
in 1873 by Hesse from old barks from British India.

_Paricine_ is another basic substance discovered in 1845 by Winckler,
in the bark of _Buena hexandra_ Pohl. Hesse detected it along with
quinamine in the bark of _C. succirubra_; its composition is not yet
known.

_Aricine_, C₂₃H₂₆N₂O₄, and _Cusconine_, C₂₃H₂₆N₂O₄ + 2 OH₂, occur in
the so-called false Cinchona barks of not ascertained botanic origin.
These alkaloids differ in many respects from those of true Cinchona
barks.[1355]

_Pitoyine_ was pointed out by Peretti (1837), but Hesse has shown
(1873) that the bark called _China bicolorata Tecamez_[1356] or _Pitoya
Bark_ from which it was obtained, is altogether destitute of alkaloid.

Lastly may be mentioned _Paytine_, C₂₁H₂₄N₂O + OH₂, a crystallizable
alkaloid discovered in 1870 by Hesse in a white bark of uncertain
origin.[1357] It is allied to quinamine and quinidine, but has not been
met with in any known cinchona bark.

By heating for a length of time solutions of the cinchona alkaloids
with an excess of some mineral acid, Pasteur (1753) obtained amorphous
modifications of the natural bases. Quinine thus afforded _Quinicine_,
having the same composition; cinchonine and cinchonidine furnished
_Cinchonicine_, likewise agreeing in composition with the alkaloids
from which it originates. These amorphous products may also be obtained
by heating the natural bases in glycerin at 200° C., when a red
substance is also formed. In quinine manufactories, amorphous alkaloids
are constantly met with, being partly produced in the course of the
manipulations to which the materials are subjected. Yet cinchona barks
also afford _amorphous alkaloids_ at the very outset of analysis,
whence we must infer their existence in the living plant.

The name _Quinoidine_ (or rather “_Chinioïdin_”) was applied by
Sertürner (1829) to an uncrystallizable basic substance, which he
prepared from cinchona barks, and found to be a peculiar alkaloid. The
term has subsequently been bestowed upon a preparation which has found
its way into commerce and medical practice, in the form of a dark brown
brittle extractiform mass, softening below 100° C., and having usually
a slight alkaline reaction. It is obtained in quinine factories by
precipitating the brown mother-liquors with ammonia, and contains the
amorphous alkaloids naturally occurring in the barks. Quinoidin should
not be used unless, when previously dried at 100°, it proves to afford
at least 70 per cent. of alkaloids soluble in ether.

Quinine and the allied alkaloids have not been met with in any
appreciable amount in other parts of the cinchonas than the bark, nor
has their presence been ascertained in other plants than those of the
tribe _Cinchoneæ_.

[1355] _Yearbook of Pharm._ 1878. 59.

[1356] So called from Tecamez or Tacames, a small port of Ecuador
in about lat. 1° N. The bark which was first noticed in Lambert’s
_Description of the Genus Cinchona_, 1797. 30. tab. ii., is of unknown
botanical origin. In its external appearance, as well as in its
structure, this bark is widely different from any Cinchona bark.—See
also Vogl, in the second pamphlet quoted at page 391. 10; Oberlin and
Schlagdenhauffen, _Journ. de Pharm._ 28. (1878) 252.

[1357] Flückiger in Wiggers and Husemann, _Jahresbericht_ for 1872. 132.

Characters of the Cinchona Alkaloids.

1. _Quinine._—It is obtained from alcoholic solutions, in prisms of
the composition C₂₀H₂₄N₂O₂ + 3 OH₂, fusing at 57° C. The crystals may
be deprived of water by warming or exposure over oil of vitriol, and
they fuse at 177° C. The anhydrous alkaloid is likewise crystallizable;
it requires about 21 parts of ether for solution, but dissolves more
readily in chloroform or absolute alcohol. These solutions deviate the
ray of polarized light to the left, and so do likewise solutions of the
salts of quinine. Yet one and the same quantity of alkaloid exhibits
a very different rotatory power according to the solvent used, though
the volume of the solution remain the same. Even the common sulphate
differs in this respect from the two other sulphates of quinine. The
same remark applies to the optical power of the other alkaloids.

If ten volumes of a solution of quinine, or of one of its salts, are
mixed in a test tube with one volume of chlorine water, and a drop
of ammonia is added, a brilliant green colour makes its appearance.
In solutions rich in quinine, a green precipitate, _Thalleioquin_ or
_Dalleiochine_ is produced; in solutions containing less than ¹/₁₀₀₀
of quinine, no precipitate is formed, but the fluid assumes a green
even more beautiful than in a stronger solution. The test succeeds
with a solution containing only one part of quinine in 5,000, and in a
solution containing not more than ¹/₂₀₀₀ of quinine, if bromine is used
instead of chlorine.[1358]

The bitter taste of quinine is not appreciable in solutions containing
less than one part in 100,000. The blue fluorescence displayed by a
solution of quinine in dilute sulphuric acid is observable in solutions
containing much less than one part in 200,000 of water; yet it is not
apparent in very strong solutions.

Besides the _common medicinal_ sulphate, 2 C₂₀H₂₄N₂O₂ + SO₄H₂ + 8 OH₂,
quinine forms two other crystallizable sulphates, namely the sulphate,
C₂₀H₂₄N₂O₂ + SO₄H₂ + 7 OH₂, and a third having the composition
C₂₀H₂₄N₂O₂ + 2 SO₄H₂ + 7 OH₂.

Herapath, at Bristol, showed in 1852 that quinine forms with sulphuric
acid and iodine a peculiar compound, _Iodo-sulphate of Quinine_,
having the composition (C₂₀H₂₄N₂O₂)₄ + 3 (SO₄H₂) + 2 HI + 4 I + 3
OH₂. As this substance possesses optical properties analogous to
those of tourmaline, it was called by Haidinger, _Herapathite_. It
may be easily obtained by dissolving sulphate of quinine in 10 parts
of weak spirit of wine containing 5 per cent. of sulphuric acid, and
adding an alcoholic solution of iodine until a black precipitate is no
longer formed. This precipitate is collected on a filter and washed
with alcohol; then dissolved in boiling spirit of wine and allowed
to crystallize. The tabular crystals thus obtained are extremely
remarkable on account of their dichroism and polarizing power, as well
as for the sparing solubility, since they require 1000 parts of boiling
water for solution; their sparing solubility in cold alcohol may be
utilized for separating quinine from the other cinchona alkaloids and
estimating its quantity.

2. _Quinidine_ or _Conquinine_—forms crystals having the composition,
C₂₀H₂₄N₂O₂ + 2 OH₂; the anhydrous alkaloid melts at 168° C., and
requires about 30 parts of ether for solution. Its solutions are
strongly dextrogyre; it agrees with quinine as regards bitterness,
fluorescence and the thalleioquin test, and forms a neutral and an
acid sulphate. The most striking character of quinidine is afforded by
its hydriodate, the crystals of which require for solution at 15° C.,
1250 parts of water or 110 parts of alcohol sp. gr. ·834. Quinidine
may therefore be separated from the other alkaloids of bark by a
solution of iodide of potassium which will precipitate the hydriodate.
According to Hesse (1873), quinidine is further characterized by the
fact that its sulphate is soluble in 20 parts of chloroform at 15° C.,
the sulphates of the other cinchona alkaloids being far less soluble in
that liquid. The common medicinal sulphate of quinine, _e.g._, requires
for solution 1000 parts of chloroform.

[1358] _Pharm. Journ._, May 11, 1872. 901.

3. _Cinchonine._—This alkaloid forms crystals which are always
anhydrous; they fuse at 257° C., and require about 400 parts of ether
and 120 of spirit of wine for solution. Cinchonine further differs from
quinine by its dextrogyre power, its want of fluorescence, and its
non-susceptibility to the thalleioquin test. Its hydriodate is readily
soluble in water, and still more so in alcohol whether dilute or strong.

4. _Cinchonidine._—forms anhydrous crystals melting at 206° C., soluble
in 76 parts of ether, or 20 of spirit of wine, then affording levogyre
liquids, devoid of fluorescence, and not acquiring a green colour
(thalleioquin) by means of chlorine water and ammonia. Hydrochlorate of
cinchonidine forms pyramidal crystals of the monoclinic system, very
different from the hydrochlorates of the allied alkaloids.

5. _Quinamine._—The crystals are anhydrous, fuse at 172° C., and form
at a temp. of 20°, with 32 parts of ether or 100 parts of spirit of
wine, a dextrogyre solution. Quinamine is even to some extent soluble
in boiling water, and abundantly in boiling ether, benzol, or petroleum
ether. The solutions of quinamine do not stand the thalleioquin test,
nor do they display fluorescence; in acid solution, the alkaloid
is liable to be transformed into an amorphous state. Quinamine
moistened with concentrated nitric acid, assumes like paytine a yellow
coloration. Its hydriodate is readily soluble in boiling water, but
very sparingly in cold water, especially in presence of iodide of
potassium, in which respect it is allied to quinidine as well as to
paytine.

The more important properties of the Cinchona alkaloids may be
summarized as follows:—

    a.  _Hydrated_ crystals are formed by
                                   Quinine, Quinidine, (or Conquinine).
        _No hydrated_ crystals by
                                   Cinchonine, Cinchonidine, Quinamine.

    b.  _Abundantly_ soluble in ether
                                      Quinine, Quinidine, Quinamine,
                                      and the amorphous alkaloids.
        _Sparingly_ soluble in ether  Cinchonidine.
        _Almost insoluble_ in ether   Cinchonine.

    c.  _Levogyre_ solutions afforded by
                                      Quinine, Cinchonidine.
        _Dextrogyre_ solutions by
                            Cinchonine, Quinidine, Quinamine,
                            Conquinamine, and the amorphous alkaloids.

    d.  Thalleioquin is formed by
                             Quinine, Quinidine, and also by Quinicine.
        Thalleioquin cannot be obtained from
                                  Cinchonine, Cinchonidine, Quinamine,
                                  nor from Cinchonicine.

    e.  Fluorescence is displayed by solutions of Quinine, Quinidine.
        No fluorescence in solutions of pure Cinchonine, Cinchonidine,
             Quinamine.

=Proportion of Alkaloids in Cinchona Barks=—This is liable to very
great variation. We know from the experiments of Hesse (1871), that
the bark of _C. pubescens_ Vahl is sometimes devoid of alkaloid.[1359]
Similar observations made near Bogota upon _C. pitayensis_ Wedd., _C.
corymbosa_ Karst., and _C. lancifolia_ Mutis, are due to Karsten. He
ascertained[1360] that barks of one district were sometimes devoid of
quinine, while those of the same species from a neighbouring locality
yielded 3½ to 4½ per cent. of sulphate of quinine.

[1359] _Berichte der Deutschen Chem. Gesellschaft zu Berlin_, 1871. 818.

[1360] _Die medicinischen Chinarinden Neu-Granada’s_, 17. 20. 39.

Another striking example is furnished by De Vry[1361] in his
examination of quills of _C. officinalis_ grown at Ootacamund, which
he found to vary in percentage of alkaloids, from 11·96 (of which 9·1
per cent. was quinine) down to less than 1 per cent. An extremely
remarkable variation has also been displayed, as already alluded to at
p. 351, by Ledger’s Calisaya.

Among the innumerable published analyses of cinchona bark, there
are a great number showing but a very small percentage of the
useful principles, of which quinine, the most valuable of all, is
not seldom altogether wanting. The highest yield on the other hand
hitherto observed, was obtained by Broughton[1362] from a bark grown
at Ootacamund. This bark afforded not less than 13½ per cent. of
alkaloids, among which quinine was predominant. In Java too, Cinchona
Ledgeriana (see pp. 341, 351) has proved since to afford much more
alkaloid than any American barks; as much as 13·25 per cent. of quinine
have been observed in its bark.

The few facts just mentioned show that it is impossible to state even
approximately any constant percentage of alkaloids in any given bark.
We may however say that good _Flat Calisaya Bark_, as offered in the
drug trade for pharmaceutical preparations, contains at least 5 to 6
per cent. of quinine.

As to _Crown_ or _Loxa Bark_, the _Cortex Cinchonæ pallidæ_ of
pharmacy, its merits are, to say the least, very uncertain. On its
first introduction in the 17th century, when it was taken from the
trunks and large branches of full-grown trees, it was doubtless an
excellent medicinal bark; but the same cannot be said of much of that
now found in commerce, which is to a large extent collected from very
young wood.[1363] Some of the Crown Bark produced in India is however
of extraordinary excellence, as shown by the recent experiments of De
Vry.[1364]

As to _Red Bark_, the thick flat sort contains only 3 to 4 per cent. of
alkaloids, but a large amount of coloring matter. The quill Red Bark of
the Indian plantations is a much better drug, some of it yielding 5 to
10 per cent. of alkaloids, less than a third of which is quinine and a
fourth cinchonidine, the remainder being cinchonine and sometimes also
traces of quinidine (conquinine).

The variations in the amount of alkaloids relates not merely to their
total percentage, but also to the proportion which one bears to
another. Quinine and cinchonine are of the most frequent occurrence;
cinchonidine is less usual, while quinidine is still less frequently
met with and never in large amount. The experiments performed in
India[1365] have already shown that external influences contribute in
an important manner to the formation of this or that alkaloid; and
it may even be hoped that the cultivators of cinchona will discover
methods of promoting the formation of quinine and of reducing, if not
of excluding, that of the less valuable alkaloids.

[1361] _Pharm. Journ._ Sept. 6, 1873. 181.

[1362] Blue Book—“_East India Chinchona Plant_,” 1870. 282; _Yearbook
of Pharmacy_, 1871. 85.

[1363] See Howard’s analyses and observations, _Pharm. Journ._ xiv.
(1855) 61-63.

[1364] _Pharm. Journ._ Sept. 6, 1873. 184.

[1365] Blue Book, 1870. 116. 188. 205.

Most salts of the alkaloids of cinchona afford a beautiful purple tar
when they are heated in a test tube, and the same is also produced with
the powdered bark, provided alkaloids be present. No other bark, as
far as we know, yields a similar product of the dry distillation. It
is not observed even in using true Cinchona barks, which are devoid of
alkaloids. This method for ascertaining the presence of alkaloids in
Cinchona barks has been proposed in 1858 by Grahe of Kasan. Hesse has
improved Grahe’s test in the following way: he extracts the powdered
bark with slightly acidulated water and dries up the liquid with a
little of the powder. _Grahe’s test_ at once shows whether a given bark
contains Cinchona alkaloids or not.

=Acid principles of Cinchona Barks=—Count Claude de la Garaye[1366]
observed (1746) a crystalline salt deposited in extract of cinchona
bark, which salt was known for some time in France as _Sel essential
de la Garaye_. Hermbstädt at Berlin (1785) showed it to be a salt of
calcium, the peculiarity of whose acid was pointed out in 1790 by
C. A. Hoffmann,[1367] an apothecary of Leer in Hanover, who termed
it _Chinasäure_. The composition of this substance, which is the
_Kinic Acid_ of English chemists, was ascertained by Liebig in 1830
to be C₇H₁₂O₆, or now C₆H₇(OH)₄COOH. The acid forms large monoclinic
prisms, fusible at 162° C., of a strong and pure acid taste, soluble
in two parts of water, also in spirit of wine, but hardly in ether.
The solutions are levogyre. Kinic acid appears to be present in every
species, and also to occur in barks of allied genera; and in fact to
be of somewhat wide distribution in the vegetable kingdom. By heating
it or a kinate, interesting derivatives are obtained; thus, by means
of peroxide of manganese and sulphuric acid, we get yellow crystals
of _Kinone_ or _Quinone_, C₆H₄O₂,—a reaction which may be used for
ascertaining the presence of kinic acid. Kinic acid is devoid of any
noteworthy physiological action.

_Cincho-tannic Acid_—is precipitated from a decoction of bark by
acetate of lead, after the decoction has been freed from cinchona-red
by means of magnesia. Dr. de Vry informed us that the Indian barks
are usually richer in cincho-tannic acid; their cold infusion becomes
turbid on addition of hydrochloric acid, which forms an insoluble
compound with the former.

The cincho-tannate of lead decomposed by sulphuretted hydrogen, and
the solution cautiously evaporated _in vacuo_, yields the acid as an
amorphous, hygroscopic substance, readily soluble in water, alcohol, or
ether. The solutions, especially in presence of an alkali, are quickly
decomposed, a red flocculent matter, _Cinchona-red_, being produced.
Solutions of cincho-tannic acid assume a greenish colour on addition of
a ferric salt. By destructive distillation, cincho-tannic acid affords
pyrocatechin.

_Quinovic_ (or _Chinovic_) _Acid_, C₂₄H₃₈O₄, crystallizes in hexagonal
scales which are sparingly soluble in cold alcohol, more readily in
boiling alcohol, but not dissolved by water, ether, or chloroform. It
occurs in cinchona barks, and has been met with by Rembold (1868) in
the rhizome of _Potentilla Tormentilla_ Sibth.

[1366] _Chimie hydraulique_, Paris, 1746. 114.

[1367] Crell’s _Chem. Annalen_, 1790, ii. 314-317.

=Other Constituents of Cinchona Barks=—Quinovic acid is accompanied by
_Quinovin_ (or _Chinovin_), C₃₀H₄₈O₈, an amorphous bitter substance,
first obtained (1821) by Pelletier and Caventou under the name of
_Kinovic Acid_, from _China nova_,[1368] in which it occurs combined
with lime. Quinovin in alcoholic solution was shown in 1859 by
Hlasiwetz to be resolved by means of hydrochloric gas into quinovic
acid, C₂₄H₃₈O₄, and an uncrystallizable sugar, _Mannitan_, C₆H₁₂O₅,
with subtraction of H₂O. The formation of quinovic acid takes place
more easily, if quinovin is placed in contact with sodium amalgam and
spirit of wine, when, after 12 hours, mannitan and quinovate of sodium
are formed (Rochleder, 1867).

Quinovin, although an indifferent substance, may be removed from
cinchona barks by weak caustic soda, from which it is precipitable by
hydrochloric acid, together with quinovic acid and cinchona-red. Milk
of lime then dissolves quinovin and quinovic acid, but not the red
substance. Quinovic acid and quinovin again precipitated by an acid,
may be separated by chloroform in which the latter only is soluble, or
also by cold dilute alcohol sp. gr. about 0·926, quinovin being readily
removed by this liquid.

Quinovin dissolves in boiling water; its solutions, as well as those of
quinovic acid, are dextrogyre. Quinovin seems to be a constituent of
almost every part of the cinchonas and the allied _Cinchoneæ_, although
the amount of it in barks does not apparently exceed 2 per cent. It is
accompanied by quinovic acid: both substances are stated to have tonic
properties.

_Cinchona-red_, an amorphous substance to which the red hue of
cinchona barks is due, is produced as shown by Rembold (1867), when
cincho-tannic acid is boiled with dilute sulphuric acid, sugar
being formed at the same time. By fusing cinchona-red with potash,
protocatechuic acid, C₇H₆O₄, is produced. Cinchona-red is sparingly
soluble in alcohol, abundantly in alkaline solutions, but neither in
water nor in ether. Thick Red Bark in which it is abundant, affords it
to the extent of over 10 per cent.

The Cinchona barks yield but a scanty percentage of ash, not exceeding
3 per cent., a fact well according with the small amount they contain
of oxalate and kinate of calcium.

=Estimation of the Alkaloids in Cinchona Bark=—The microscope will
enable us, as already shown, to ascertain whether a given bark is
derived from _Cinchona_, but it can furnish no exact information as to
the actual value of such bark as a drug.

Yet there is a very simple test by which the presence of a
cinchona-alkaloid may be demonstrated. These alkaloids heated in a
glass tube in the presence of a volatile acid or of substances capable
of producing a volatile acid, evolve heavy vapours of a beautiful
crimson colour, as mentioned p. 363.

[1368] The bark of _Buena magnifolia_ Wedd., a tree with fragrant
flowers and magnificent foliage, figured in Howard’s “_Nueva Quinologia
of Pavon_” as Cinchona magnifolia. Its bark is destitute of alkaloids;
it also used to appear occasionally in the London market since about
the year 1820.—See also our article on _Cortex Cascarillæ_.

But to ascertain the real value of a cinchona bark, a quantitative
estimation of the alkaloids is necessary. A good process for this
operation has been given by De Vry.[1369] It is as follows:—Mix 20
grammes of powdered bark, dried at 100° C., with milk of lime (5 grm.
slaked lime to 50 grm. water), dry the mixture slowly; by stirring
it frequently, the cincho-tannic acid loses its solubility, being
gradually transformed into cinchona-red. Then boil the dry powder with
200 cubic centimetres of alcohol 0·830 sp. gr. Pour the liquid on to a
small filter, and afterwards the residual bark and lime mixed with 100
cub. cent. more alcohol. Wash the powder on the filter with 100 cub.
cent. of spirit From the mixed liquids, about 370 cub. cent., separate
the calcium by a few drops of weak sulphuric acid. Filter, distill off
the spirit and pour into a capsule the residual liquid,—to which add a
small quantity of spirit and water with which the distilling apparatus
has been rinsed out. Let the capsule be now heated on a water-bath
until all the spirit shall have been expelled; and let the remaining
liquor which contains all the alkaloids in the form of acid sulphates
be filtered. There will remain on the filter quinovic acid and fatty
substances, which must be washed with slightly acidulated water. The
filtrate and washings reduced to about 50 cub. cent., should be treated
while still warm with caustic soda in excess. After cooling, this is
decanted off from the precipitate, and then water added to it before
throwing it on to a filter. It is then to be washed with the smallest
quantity of water pressed between folds of blotting paper, removed
therefrom and dried. The weight multiplied by 5 will indicate the
percentage of _mixed_ alkaloids in the bark.

[1369] _Pharm. Journ._ iv. (1873) 241, and Dr. de Vry’s papers
mentioned at the end of the present article, p. 369; also private
communications.

To separate the alkaloids from each other, treat the powdered mass
with ten times its weight of ether. This will resolve it into two
portions—(a) _insoluble in ether_, (b) _soluble in ether_.

(a.) This should be converted into neutral acetates, and to the
solution there should be added iodide of potassium, which will possibly
separate a little _quinidine_. After removal of the latter (if
present), add solution of tartrate of potassium and sodium, which will
throw down in a crystalline form tartrate of _cinchonidine_; from the
mother-liquor, _cinchonine_ may be precipitated by caustic soda.

(b.) The ether having been evaporated, the residue is to be dried at
100° C. and weighed. It may in many cases practically be considered
as consisting of quinine only. If however the estimation of quinidine
(conquinine) and quinamine is required, the residue, or a determined
portion of it, should be dissolved in acetic acid just as much as
will be necessary for affording a neutral solution. From this the
hydroiodate of quinidine is precipitated by means of an alcoholic
solution of iodide of potassium. In the filtrate quinine may be
precipitated by adding a few drops of dilute sulphuric acid and an
alcoholic tincture of iodine. The herapathite thus formed (see p. 360)
is collected after a day, dried at 100° and weighed; it then contains
55 per cent. of quinine.

After adding a few drops of sulphurous acid, the alcohol should now be
evaporated from the fluid from which the crystals of herapathite have
been removed, and caustic lye added, by which the amorphous alkaloids
will be precipitated, including _quinamine_ if present.

=Uses=—Cinchona bark enjoys the reputation of being a most valuable
remedy in fevers. But the uncertainty of its composition and its
inconvenient bulk render it a far less eligible form of medicine than
the alkaloids themselves. It is nevertheless much used as a general
tonic in various pharmaceutical preparations.

As to the alkaloids, the only one which is in general use is _quinine_.
The neglect of the others is a regrettable waste, which the result of
recent investigations ought to obviate. In the year 1866 the Madras
Government appointed a Medical Commission to test the respective
efficacy in the treatment of fever, of Quinine, Quinidine, Cinchonine
and Cinchonidine. Of the sulphates of these alkaloids, a due supply,
specially prepared under Mr. Howard’s superintendence, was placed
at the disposal of the Commission. From the report[1370] it appears
that the number of cases of paroxysmal malarious fevers treated was
2472,—namely 846 with Quinine, 664 with Quinidine, 569 with Cinchonine,
and 403 with Cinchonidine. Of these 2472 cases, 2445 were cured, and
27 failed. The difference in remedial value of the four alkaloids, as
deduced from these experiments, may be thus stated:—

    Quinidine—ratio of failure per 1000 cases treated   6
    Quinine          ”           ”                       7
    Cinchonidine     ”           ”                      10
    Cinchonine       ”           ”                      23

The Indian Government, acting on the recommendation of Mr. Howard,
has officially advised (Dec. 16, 1873) the more free use India of
cinchona alkaloids other than quinine, and especially of _sulphate of
cinchonidine_, which is procurable in abundance from Red Bark.[1371]
Quinidine on the other hand, which has proved the most valuable of all,
is only obtainable from a few barks and in very limited amount.

Dr. de Vry since 1876 advocates the use of what he calls _Quinetum_.
This preparation is obtained by exhausting the barks with slightly
acidulated water, and precipitating the whole amount of alkaloids by
caustic soda. In India the remedy is known as “the Febrifuge.”[1372]

=Adulteration=—There is not now any frequent importation of _spurious_
cinchona barks, but the substitution of bad varieties for good is
sufficiently common. To discriminate these in a positive manner by
ascertaining the percentage of quinine, which is the chief criterion
of value, recourse must be had to chemical analysis, a method of
performing which has been described. Entirely worthless barks may be
easily recognized by means of Grahe’s test (p. 363).

[1370] Blue Book—_East India Cinchona Cultivation_, 1870. pp.
156-172.—The report contains very interesting and important medical
details. See also Dougal in _Edin. Med. Journ._ Sept. 1873.

[1371] We heard that the Government has purchased (April 1874) by
tender between 300 and 400 lb. of cinchonidine.

[1372] _Pharm. Journ._ viii. (1878) 1060.

Modern Works relating to Cinchona.

The following enumeration has been drawn up for the sake of those
desiring more ample information than is contained in the foregoing
pages, but it has no pretension to be a complete list of all
publications that have lately appeared on the subject.

    Berg (Otto), _Chinarinden der pharmakognostischen Sammlung
        zu Berlin_. Berlin, 1865, 4°. 48 pages and 10 plates
        showing the microscopic structure of barks.

    Bergen (Heinrich von), _Monographie der China_.
        Hamburg, 1826, 4°. 348 pages and 7 coloured plates
        representing the following barks:—China rubra, Huanuco,
        Calisaya, flava, Huamalies, Loxa, Jaen. An exhaustive
        work for its period in every direction.

    Blue books—_East India_ (_Chinchona Plant_). Folio.

      =a.= _Copy of Correspondence relating to the
          introduction of the Chinchona Plant into India, and
          to proceedings connected with its cultivation from
          March 1852 to March 1863._ Ordered by the House of
          Commons to be printed, 20 March 1863. 272 pages.

      Contains Correspondence of Royle, Markham, Spruce,
      Pritchett, Cross, McIvor, Andersen and others,
      illustrated by 5 maps.

      =b.= _Copy of further Correspondence relating to
          the introduction of the Chinchona Plant into India,
          and to proceedings connected with its cultivation,
          from April 1863 to April 1866._ Ordered by the
          House of Commons to be printed, 18 June 1866. 379
          pages.

      Contains Monthly Reports of the plantations on the
      Neilgherry Hills; Annual Reports for 1863-64, 1864-65,
      with details of method of propagation and cultivation,
      barking, mossing, attacks of insects, illustrated by
      woodcuts and 4 plates; report of Cross’s journey to
      Pitayo, with map; Cinchona cultivation in Wynaad,
      Coorg, the Pulney Hills and Travancore, with map;
      in British Sikkim, the Kangra, Valley (Punjab), the
      Bombay Presidency, and Ceylon.

      =c.= _Copy of all Correspondence between the
          Secretary of State for India and the Governor-General,
          and the Governors of Madras and Bombay, relating to
          the cultivation of Chinchona Plants, from April 1866
          to April 1870._ Ordered by the House of Commons to
          be printed, 9 August 1870. 285 pages.

      Contains reports on the Neilgherry and other plantations,
      with map; appointment of Mr. Broughton as analytical
      chemist, his reports and analyses; reports on the
      relative efficacy of the several cinchona alkaloids,
      on cinchona cultivation at Darjiling and in British Burma.

      =d.= _Copies of the Chinchona Correspondence (in
          continuation of return of 1870), from August 1870 to
          July 1875._ Ordered by the House of Commons to be
          printed, 21 June 1877. 190 pages.

      Contain also reports on the alkaloid manufactory in India,
      collection and shipment of barks, and analyses of barks.

    Delondre (Augustin Pierre) et Bouchardat (Apollinaire),
        _Quinologie_, Paris, 1854, 4°. 48 pages, and 23
        good coloured plates exhibiting all the barks then met
        with in commerce.

    Delondre (Augustin), see Soubeiran.

    Gorkom (K. W. van), _Die Chinacultur auf Java_,
        Leipzig, 1869, 61 pages. An account of the management of
        the Dutch plantation.

    Hesse (Oswald). This chemist has summarized his elaborate
        researches on Cinchona in the German Dictionary of
        Chemistry, articles Chinin, Cinchonin, etc. 1876-1877.

    Howard (John Eliot), _Illustrations of the Nueva
        Quinologia of Pavon_. London, 1862, folio, 163 pages
        and 30 beautiful coloured plates.—Figures of Cinchona
        mostly taken from Pavon’s specimens in the herbarium of
        Madrid, and three plates representing the structure of
        several barks.

    Howard (J. E.), _Quinology of the East India
        Plantations_. London, 1869, folio x. and 43
        pages, with 3 coloured plates exhibiting structural
        peculiarities of the barks of cultivated _Cinchonæ_.

    Howard (J. E.) The same, parts ii. and iii., Lond. 1876,
        folio xiv. and 74 p., with 2 views, 2 black plates
        and 13 coloured figures of _Cinchona Calisaya_
        (_Ledgeriana_), _C. officinalis_, _C.
        pitayensis_, and others.

    Karsten (Hermann), _Die medicinischen Chinarinden
        Neu-Granada’s_. Berlin, 1858, 8°. 71 pages, and 2
        plates showing microscopic structure of a few barks. An
        English translation prepared under the supervision of
        Mr. Markham, has been printed by the India Office under
        the title of _Notes on the Medicinal Cinchona Barks of
        New Granada by H. Karsten_, 1861. The plates have not
        been reproduced.

    Karsten (Hermann), _Floræ Columbiæ terrarumque adjacentium
        specimina selecta_. Berolini, 1858, folio. Beautiful
        coloured figures of various plants including Cinchona,
        under which name are several species usually referred to
        other genera. Only three parts have been published.

    King (George), _A Manual of Cinchona cultivation in
        India_. Calcutta, 1876, 80 pages, small folio.

    Kuntze (Otto), _Cinchona. Arten, Hybriden and Cultur der
        Chininbäume._ Leipzig, 1878. 124 pages and 3 plates.
        A review of this book will be found in the _Archiv der
        Pharmacie, 213_, (1878) 473-480.

    McIvor (W. G.) _Notes on the propagation and cultivation
        of the medicinal Cinchonas or Peruvian bark trees._
        Madras, 1867, 33 pages, 9 plates. The author explains
        the “motsing system” alluded to p. 362.

    McIvor (William Graham), _A letter on the cultivation of
        Chinchona on the Nilgiris_. Ootacamund, 1876, 27
        pages.

    Markham (Clements Robert), _The Chinchona Species of
        New Granada, containing the botanical descriptions of
        the species examined by Drs. Mutis and Karsten; with
        some account of those botanists, and of the results
        of their labours_. London, 1867, 8°. 139 pages and
        5 plates. The plates are not coloured, yet are good
        reduced copies of those contained in Karsten’s _Floræ
        Columbiæ_; they represent the following:—_Cinchona
        corymbosa_, _C. Trianæ_, _C. lancifolia_,
        _C. cordifolia_, _C. tucujensis_.

    Markham. _A Memoir of the Lady Ana de Osorio, Countess
        of Chinchon, vice-queen of Peru_ (A.D.
        1629-1639), _with a plea for the correct spelling of
        the Chinchona genus_. London, 1874, 4°. 99 pages,
        with a map, heraldic figures and views.

        See also Hanbury, _Science Papers_, 1876, p. 475.

    Miquel (Friedrich Anton Wilhelm), _De Cinchonæ speciebus
        quibusdam, adjectis iis quæ in Java coluntur.
        Commentatio ex Annalibus Musei Botanici Lugduno-Batavi
        exscripta._ Amstelodami, 1869,4°. 20 pages.

    Oudemans (Anthony Cornelis), _Sur le pouvoir rotatoire
        spécifique des principaux alcaloïdes du quinquina_.
        _Archives néerlandaises_, x. (1875), 193-268, and
        xii. (1877).

    Phoebus (Philipp), _Die Delondre-Bouchardat’schen
        China-Rinden_. Giessien, 1864, 8°. 75 pages and a
        table. The author gives a description without figures,
        of the microscopic structure of the type-specimens
        figured in Delondre and Bouchardat’s _Quinologie_.

    Planchon (Gustave), _Des Quinquinas_. Paris et
        Montpellier, 1864, 8°. 150 pages. A description of the
        cinchonas and their barks. An English translation has
        been issued under the superintendence of Mr. Markham by
        the India Office, under the title of _Peruvian Barks
        by Gustave Planchon_. London, printed by Eyre and
        Spottiswoode, 1866.

    Soubeiran (J. Léon) et Delondre (Augustin), _De
        l’introduction et de l’acclimation des Cinchonas
        dans les Indes néerlandaises et dans les Indes
        britanniques_. Paris, 1868, 8°. 165 pages.

    Triana (Josè), _Nouvelles études sur les Quinquinas_.
        Paris, 1870, folio, 80 pages, and 33 plates. An
        interesting account of the labours of Mutis, illustrated
        by uncoloured copies of some of the drawings prepared
        by him in illustration of his unpublished _Quinologia
        de Bogotá_, especially of the several varieties
        of _Cinchona lancifolia_; also an enumeration
        and short descriptions of all the species of
        _Cinchona_, and of New Granadian plants (chiefly
        _Cascarilla_) formerly placed in that genus.

        An abstract of the book will be found in Just’s
        _Botanischer Jahresbericht_ für 1873, 484-494.

    Vogl (August), _Chinarinden des Wiener Grosshandels und
        der Wiener Sammlungen_. Wien, 1867, 8°. 134 pages,
        no figures. A very exhaustive description of the
        microscopic structure of the barks occurring in the
        Vienna market, or preserved in the museums of that city.

    Vogl (A.), _Beiträge zur Kenntniss der sogenannten
        falschen Chinarinden_. Wien, 1876, 4°. 26 pages, 7
        microscopic sections.

    Vrij (John Eliza de), _Kinologische studiën_. More
        than 30 papers published since 1868 in the _Nieuw
        Tijdschrift voor de Pharmacie in Nederland_. They are
        chiefly devoted to the chemistry of the barks from Java
        and British India.

    Weddell (Hugh Algernon), _Histoire naturelle des
        Quinquinas, ou monographie du genre Cinchona, suivie
        d’une description du genre Cascarilla et de quelques
        autres plantes de la même tribu_. Paris, 1849, folio,
        108 pages, 33 plates, and map. Excellent uncoloured
        figures of Cinchona and some allied genera, and
        beautiful coloured drawings of the officinal barks.
        Plate I. exhibits the anatomical structure of the plant;
        Plate II. that of the bark.

    Weddell (H. A.), _Notes sur les Quinquinas, Extrait des
        Annales des Sciences naturelles_, 5ᵉ série, tomes
        xi. et xii. Paris, 1870, 8°. 75 pages. A systematic
        arrangement of the genus _Cinchona_, and
        description of its (33) species, accompanied by useful
        remarks on their barks. An English translation has been
        printed by the India Office with the title—_Notes
        on the Quinquinas by H. A. Weddell_, London, 1871,
        8°. 64 pages. A German edition by Dr. F. A Flückiger
        has also appeared under the title _Uebersicht der
        Cinchonen von H. A. Weddell_. Schaffhausen and
        Berlin, 1871, 8°. 43 pages, with additions and indexes.


RADIX IPECACUANHÆ.

_Ipecacuanha Root_, _Ipecacuan_; F. _Racine d’Ipécacuanha annelee_; G.
_Brechwurzel_.

=Botanical Origin=—_Cephaëlis[1373] Ipecacuanha_ A. Richard—This is a
small shrub, 8 to 16 inches high, with an ascending, afterwards erect,
simple stem, and somewhat creeping root, growing socially in moist
and shady forests of South America, lying between 8° and 22° S. lat.,
especially in the Brazilian provinces of Pará, Maranhão, Pernambuco,
Bahia, Espiritu Santo, Minas, Rio de Janeiro, and São Paulo. Within the
last half century, it has been discovered in the vast interior province
of Matto Grosso, chiefly in that part of it which forms the valley of
the Rio Paraguay. From information given to Weddell,[1374] it would
seem probable that the plant extends beyond the frontiers of Brazil to
the Bolivian province of Chiquitos.

The root which is brought into commerce is furnished chiefly by the
region lying between the towns of Cuyabá, Villa Bella, Villa Maria, and
Diamantina in the province of Matto Grosso; but to some extent also by
the woods in the neighbourhood of the German colony of Philadelphia on
the Rio Todos os Santos, a tributary of the Mucury, north of Rio de
Janeiro.

Prof. Balfour of Edinburgh, who has paid much attention to the
propagation of ipecacuanha, finds that the plant exists under two
varieties, of which he has published figures;[1375] they may be thus
distinguished:

      _a._ Stem woody, leaves of firm texture, elliptic
           or oval, wavy at the edges, with but few hairs on
           surface and margin. Long in cultivation: origin unknown.

      _b._ Stem herbaceous, leaves less firm in texture,
           more hairy on margin, not wavy. Grows in the neighbourhood
           of Rio de Janeiro.

The plant cultivated in India seems disposed to run into several
varieties, but according to the experience gained in Edinburgh, the
diversity of form apparent in young plants tends to disappear with age.

=History=—In an account of Brazil, written by a Portuguese friar, who,
it would seem, had resided in that country from about 1570 to 1600, and
published by Purchas,[1376] mention is made of three remedies for the
bloody flux, one of which is called _Igpecaya_ or _Pigaya_; the drug
here spoken of is probably that under notice.

[1373] I am informed by my friend Professor Müller of Geneva that in
describing the Rubiaceæ for the _Flora Brasiliensis_ he will include
Cephaëlis Ipecacuanha in the genus _Mapouria_.—F. A. F.. March 1879.

[1374] _Ann. des Sciences nat._ Bot. xi. (1849) 193-202.

[1375] _Trans. of Roy. Soc. of Edinb._ xxvi. (1872) 781. plates
31-32.—Fig. in Bentley and Trimen, _Med. Plants._ part 15 (1876).

[1376] Purchas, _His Pilgrimes_, Lond. iv. (1625),—a treatise of
Brasill, written by a Portugall which had long lived there, p. 1311.

Piso and Marcgraf[1377] in their scientific exploration of Brazil
met with two kinds of ipecacuanha; the one provided with a brown
root is Cephaëlis Ipecacuanha, which they figured. The root of the
other variety, which they called _Ipecacuanha blanca_, is that of
Richardsonia scabra (see page 376 below). Piso and Marcgraf described
the virtues of these roots, apparently supposing them to be much the
same as to their action. Although in common use in Brazil, ipecacuanha
was not employed in Europe prior to the year 1672. At that date, a
traveller named Legras brought from South America a quantity of the
root to Paris, some of which came into the possession of the “maître
appoticaire” Claquenelle.[1378] It would appear that the root was
prescribed from the latter by Legras (said to have been himself
acquainted with the practice of medicine[1379]), and also by Jean
Adrien Helvetius, a young Dutch physician, then living in Paris. Yet no
success at first was obtained, the drug being administered in too large
doses. In 1680, a merchant of Paris named Garnier became possessed of
150 lb. of ipecacuanha, the valuable properties of which in dysentery
he vaunted to his medical attendant Afforty, and to Helvetius. Garnier
on his convalescence[1380] made a present of some of the new drug to
Afforty, who attached to it but little importance. Helvetius, on the
other hand, was induced to prescribe the root in cases of dysentery,
which he did with the utmost success. It is stated by Eloy that
Helvetius even caused placards to be affixed to the corners of the
streets (about the year 1686), announcing his successful treatment
with the new drug, supplies of which he obtained through Garnier from
Spain, and sold as a secret medicine. The fame of the cures effected by
Helvetius reached the French Court, and caused some trials of the drug
to be made at the Hôtel Dieu. These having been fully successful, Louis
XIV. accorded to Helvetius the sole right of vending his remedy.[1381]
Subsequently several great personages, including the Dauphin of France,
having experienced its benefit, the king consulted his physician,
Antoine d’Aquin, and the well-known Jesuit Père François de Lachaise,
who had become the King’s confessor in 1675. Through them was chiefly
negotiated the purchase from Helvetius of his secret, for 1000 louis
d’or, and made public in 1688. The right of Helvetius to this payment
was disputed in law by Garnier, but maintained by a decision of the
Châtelet of Paris.[1382]

The botanical source of ipecacuanha was the subject of much dispute
until finally settled by Antonio Bernardino Gomez, a physician of the
Portuguese navy, who brought authentic specimens from Brazil to Lisbon
in the year 1800.[1383]

[1377] _Hist. nat. Brasil._ 1648. Piso, p. 101, Marcgraf, p. 17.

[1378] Pomet, _Histoire générale des Drogues_, i. (1694) 47.

[1379] Mérat and De Lens, _Dict. de Mat. Méd._ iii. (1831) 644, call
Legras a physician, and say that Garnier brought himself the 150 lb.
from abroad.

[1380] Eloy, _Histoire générale de la Médecine_. Mons. ii. (1778)
485, mentions a _sick druggist_, who presented Helvetius with
the ipecacuanha. Garnier, according to Eloy, was a “Marchand
chapelier.”—Leibnitz, in _Ephemerid. Academ. Cæsareo-Leopold_, 1696,
Appendix, p. 6, miscalled the merchant Grenier.

[1381] An abstract of the royal patent is given by Leibnitz, _l. c._ 20
(date not added).

[1382] On the history of ipecacuanha, consult also Sprengel,
_Geschichte der Arzneykunde_, iv. (1827) 542.—We have not seen the
pamphlet quoted by Haller, _Bibl. bot._ ii. 17: Helvetius, _Usage de
l’Hipecacoanha_. 4° (no date).

[1383] _Trans. of Linn. Soc._ vi. (1801) 137.

=Collection=[1384]—The ipecacuanha plant, _Poaya_ of the Brazilians,
grows in valleys, yet prefers spots which are rather too much raised
to be inundated or swampy. Here it is found under the thick shade of
ancient trees growing mostly in clumps. In collecting the root, the
_poayero_, for so the collector of _poaya_ is called, grasps in one
handful if he can, all the stems of a clump, pushing under it obliquely
into the soil a pointed stick to which he gives a see-saw motion. A
lump of earth enclosing the roots is thus raised; and, if the operation
has been well performed, those of the whole clump are got up almost
unbroken. The _poayero_ shakes off adhering soil, places the roots in a
large bag which he carries with him, and goes on to seek other clumps.
A good collector may thus get as much as 30 lb. of roots in the day;
but generally a daily gathering does not exceed 10 or 12 lb., and there
are many who scarcely get 6 or 8 lb. In the rainy season, the ground
being lighter, the roots are removed more easily than in dry weather.
The _poayeros_, who work in a sort of partnership, assemble in the
evening, unite their gatherings, which having been weighed, are spread
out to dig. Rapid drying is advantageous; the root is therefore exposed
to sunshine as much as possible, and if the weather is favourable, it
becomes dry in two or three days. But it has always to be placed under
cover at night on account of the dew. When quite dry, it is broken into
fragments, and shaken in a sieve in order to separate adherent sand and
earth, and finally it is packed in bales for transport.

The harvest goes on all the year round, but is relaxed a little during
the rains, on account of the difficulty of drying the produce. As
fragments of the root grow most readily, complete extirpation of the
plant in any one locality does not seem probable. The more intelligent
_poayeros_ of Matto Grosso are indeed wise enough intentionally to
leave small bits of root in the place whence a clump has been dug, and
even to close over the opening in the soil.

=Cultivation=—The importance in India of ipecacuanha as a remedy for
dysentery, and the increasing costliness of the drug,[1385] have
occasioned active measures to be taken for attempting its cultivation
in that country. Though known for several years as a denizen of
botanical gardens, the ipecacuanha plant has always been rare, owing to
its slow growth and the difficulty attending its propagation.

It was discovered in 1869 by McNab, curator of the Botanical Garden
of Edinburgh, that if the annulated part of the root of a growing
ipecacuanha plant be cut into short pieces even only ¹/₁₆ of an inch
thick, and placed in suitable soil, each piece will throw out a
leaf-bud and become a separate plant. Lindsay, a gardener of the same
establishment, further proved that the petiole of the leaf is capable
of producing roots and buds, a discovery which has been utilized in the
propagation of the plant at the Rungbi Cinchona plantation in Sikkim.

[1384] Abstracted from the interesting eye-witness account of Weddell,
_l. c._

[1385] The following are the average prices at which the drug was
purchased wholesale, in London during three periods of ten years each:—

10 years ending 1850, average price 2_s._ 9½_d._ per lb. 10 ” 1860, ”
6_s._ 11½_d._ ” 10 ” 1870, ” 8_s._ 8¼_ d._ ”

In 1871, well-formed fruits were obtained from the ipecacuanha
plants growing in the Edinburgh Botanical Garden: this was promoted
by artificial fertilization, especially when the flowers of a plant
producing _long styles_ were fertilized with the pollen of one having
_short_ styles,—for _Cephaëlis_ like _Cinchona_ has dimorphic flowers.

With regard to the acclimatization of the plant in India, much
difficulty has been encountered, and successful results are still
problematical. The first plant was taken to Calcutta by Dr. King in
1866, and by 1868 had been increased to nine; but in 1870-71, it
was reported that, notwithstanding every care, the plants could not
be made to thrive. Three plants which had been sent to the Rungbi
plantation in 1868, grew rather better; and by adopting the method of
root propagation, they were increased by August 1871, to 300. Three
consignments of plants, numbering in all 370, were received from
Scotland in 1871-72, besides a smaller number from the Royal Gardens,
Kew. From these various collections, the propagation has been so
extensive, that on 31 March 1873, there were 6,719 young plants in
Sikkim, in addition to about 500 in Calcutta, and much more in 1874.

The ipecacuanha plant in India has been tried under a variety of
conditions as regards sun and shade, but thus far with only a moderate
amount of success. The best results are those that have been obtained
at Rungbi, 3000 feet above the sea, where the plants, placed in
glazed frames, were reported in May 1873 as in the most healthy
condition.[1386]

=Description=—The stem creeps a little below the surface of the soil,
emitting a small number of slightly branching contorted roots, a few
inches long. These roots when young are very slender and thread-like,
but grow gradually knotty and become by degrees invested with a very
thick bark, transversely corrugated or ringed. Close examination of the
dry root shows that the bark is raised in narrow warty ridges, which
sometimes run entirely round the root, sometimes encircle only half
its circumference. The whole surface is moreover minutely wrinkled
longitudinally. The rings or corrugations of a full sized root number
about 20 in an inch; not unfrequently they are deep enough to penetrate
to the wood.

The root attains a maximum diameter of about ²/₁₀ of an inch; but as
imported, a large proportion of it is much smaller. The woody central
part is scarcely ¹/₂₀ of an inch in diameter, subcylindrical, sometimes
striated, and devoid of pith.

Ipecacuanha is of a dusky grey hue, occasionally of a dull ferruginous
brown. The root is hard, breaks short and granular (not fibrous),
exhibiting a resinous, waxy, or farinaceous interior, white or greyish.
The bark, which constitutes 75 to 80 per cent. of the entire root, may
be easily separated from the less brittle wood. It has a bitterish
taste and faint, musty smell; when freshly dried it is probably much
more odorous. The wood is almost tasteless. In the drug of commerce
the roots are always much broken, and there is often a considerable
separation of bark from wood; portions of the non-annulated, woody,
subterraneous stem are always present.

[1386] _Annual Report of the Royal Botanical Gardens_, Calcutta, 31 May
1873—from which we have abstracted many of the foregoing particulars.
The report for 1876-1877 is by no means favourable to the prospects of
Cephaëlis in India.

During the last few years there has been imported into London a
variety of ipecacuanha, distinguished as _Carthagena_ or _New Granada
Ipecacuanha_, and differing from the Brazilian drug chiefly in being of
larger size. Thus, while the maximum diameter of the annulated roots of
Brazilian ipecacuanha is about ²/₁₀ of an inch, corresponding roots of
the New Granada variety attain nearly ³/₁₀. The latter, moreover, has a
distinct radiate arrangement of the wood, due to a greater developement
of the medullary rays, and is rather less conspicuously annulated.
Lefort (1869) has shown that the New Granada drug is a little less rich
in emetine than the ipecacuanha of Brazil.

Mr. R. B. White, of Medellin in the valley of the Cauca, New Granada,
near which place the drug has been collected, has been good enough to
send us herbarium specimens of the plant with roots attached; they
agree entirely with _Cephaëlis Ipecacuanha_.

=Microscopic Structure=—The root is coated with a thin layer of brown
cork-cells; the interior cortical tissue is made up of a uniform
parenchyme, in which medullary rays cannot be distinguished. In the
woody column they are obvious; the prevailing tissue consists of short
pitted vessels. The cortical parenchyme and the medullary rays are
loaded with small starch granules. Some cells of the interior part of
the bark contain however only bundles of acicular crystals of oxalate
of calcium.

=Chemical Composition=—The peculiar principles of ipecacuanha are
_Emetine_ and _Ipecacuanhic Acid_, together with a minute proportion of
a fœtid volatile oil. The activity of the drug appears to be due solely
to the alkaloid, which taken internally is a potent emetic.

Emetine, discovered in 1817 by Pelletier and Magendie, is a bitter
substance with distinct alkaline reaction, amorphous in the free state
as well as in most of its salts; we have succeeded in preparing a
crystallized hydrochlorate.

The root yields of the alkaloid less than 1 per cent.; the numerous
higher estimates that have been given relate to impure emetine, or have
been arrived at by some defective methods of analysis.[1387]

[1387] See the results obtained by Richard and Barruel, by Magendie and
Pelletier, and by Attfield, as recorded by the last named chemist in
_Proceedings of the British Pharmaceutical Conference_ for 1869. 37-39.

The formula assigned to emetine by Reich (1863) was C₂₀H₃₀N₂O, that
given by Glénard (1875) C₁₅H₂₂NO₂, and lastly that found in 1877 by
Lefort and F. Würtz, C₂₈H₄₀N₂O₅.

The alkaloid may be obtained by drying the powdered bark of the root
with a little milk of lime, and exhausting the mixture with boiling
chloroform, petroleum-benzin or ether. It is a white powder turning
brown on exposure to light and softening at 70° C. Emetine assumes
an intense and permanent yellow colour with solution of chlorinated
lime and a little acetic acid, as shown by Power (1877). A solution
containing but ¹/₆₀₀₀ of emetine still displays that reaction. We
found the alkaloid to be destitute of rotatory power, at least in the
chloroform solution.

The above reactions may be easily shown thus:—Take 10 grains of
powdered ipecacuanha, and mix them with 3 grains of quicklime and a few
drops of water. Dry the mixture in the water bath and transfer it to a
vial containing 2 fluid drachms of chloroform: agitate frequently, then
filter into a capsule containing a minute quantity of acetic acid,
and allow the chloroform to evaporate. Two drops of water now added
will afford a nearly colourless solution of emetine, which, placed in
a watch-glass, will readily give amorphous precipitates upon addition
of a saturated solution of nitrate of potassium, or of tannic acid, or
of a solution of mercuric iodide in iodide of potassium. To the nitrate
Power’s test may be further applied.

If the _wood_ separated as exactly as possible from the bark is used,
and the experiment performed in the same way, the solution will reveal
only traces of emetine. By addition of nitrate of potassium, no
precipitate is then produced, but tannic acid or the potassico-mercuric
iodate afford a slight turbidity. This experiment confirms the
observation that the bark is the seat of the alkaloid, as might indeed
be inferred from the fact that the wood is nearly tasteless.

_Ipecacuanhic Acid_, regarded by Pelletier as gallic acid, but
recognised in 1850 as a peculiar substance by Willigk,[1388] is
reddish-brown, amorphous, bitter, and very hygroscopic. It is related
to caffetannic and kinic acids; Reich has shown it to be a glucoside.

Ipecacuanha contains also, according to Reich, small proportions of
resin, fat, albumin, and fermentable and crystallizable sugar; also gum
and a large quantity of pectin. The bark yielded about 30 per cent.,
and the wood more than 7 per cent. of starch.

=Commerce=—The imports of ipecacuanha into the United Kingdom in 1870
amounted to 62,952 lb., valued at £16,639.[1389]

=Uses=—Ipecacuanha is given as an emetic, but much more often in small
doses as an expectorant and diaphoretic. In India it has proved of
late a most important remedy for dysentery. Since the year 1858 when
the administration of ipecacuanha in large (30 grains) doses began to
be adopted, the mortality in the cases treated for this complaint has
greatly diminished.[1390]

=Adulteration and Substitutes=—It can hardly be said that ipecacuanha
as at present imported is ever adulterated. Although it may contain
an undue proportion of the woody stems of the plant, it is not
fraudulently admixed with other roots. But it very often arrives much
deteriorated by damp: we have the authority of an experienced druggist
for saying that at least three packages out of every four offered in
the London drug sales, have either been damaged by sea-water or by damp
during their transit to the coast.

Several roots have been described as _False Ipecacuanha_, but we know
not one that would not be readily distinguished at first sight by any
druggist of average knowledge and experience.

In Brazil the word _Poaya_ is applied to emetic roots of plants of at
least six genera, belonging to the orders _Rubiaceæ_, _Violarieæ_, and
_Polygaleæ_; while in the same country, the name _Ipecacuanha_ is used
for various species of _Ionidium_[1391] as well as for _Cephaëlis_.

[1388] Gmelin, _Chemistry_, xv. (1862) 523.

[1389] _Annual Statement of the Trade and Navigation of the U.K. for
1870._—The more recent issues of this return have been simplified to
such an extent that drugs are for the greater part included under one
head.

[1390] In the Madras Presidency, the death-rate from dysentery was
71 per 1000 cases treated: under the new method of treatment, it has
been reduced to 13·5. In Bengal it has fallen from 88·2 to 28·8 per
1000.—_Supplement to the Gazette of India_, January 23, 1869.

[1391] As _Ionidium Ipecacuanha_ Vent., _I. Poaya_ St. Hil., _I.
parviflorum_ Vent., the first of which affords the _Poaya branca_
or _White Ipecacuanha_ of the Brazilians.—See C.F.P. von Martius,
_Specimen Mat. Med. Bras._ 1824; A. de St. Hilaire, _Plantes usuelles
des Brésiliens_, 1827-28.

Some of these roots, which are occasionally brought to Europe under the
notion that they may find a market, have been described and figured by
pharmacologists. We shall notice only the following:—

1. _Large Striated Ipecacuanha_—This is the root of _Psychotria
emetica_ Mutis (_Rubiaceæ_), a native of New Granada. It is
considerably stouter than true ipecacuanha, but consists like the
latter of a woody column covered with a thick brownish bark. The
latter, though marked here and there with constrictions and fissures,
is not annulated like ipecacuanha, but has very evident longitudinal
furrows. But its most remarkable character is that it remains _soft and
moist, tough to the knife_, even after many years; and the cut surface
has a dull violet hue. The root has a sweetish taste and abounds in
sugar;[1392] its decoction is not rendered blue by iodine, nor is any
starch to be detected by means of the microscope. The drug occasionally
appears in the London market.

2. _Small Striated Ipecacuanha_—This drug in outward appearance closely
resembles the preceding, but is usually of smaller size, sometimes
much smaller and in short pieces tapering towards either end. It also
differs in being brittle, abounding in starch, and having its woody
column provided with numerous pores, easily visible under a lens. Prof.
Planchon[1393] of Paris, who has particularly examined both varieties
of Striated Ipecacuanha, is of opinion that the drug under notice may
be derived from some species of _Richardsonia_.

3. _Undulated Ipecacuanha_—The root thus called is that of _Richardia
scabra_ L. (_Richardsonia scabra_ St. Hilaire), a plant of the same
order as _Cephaëlis_, very common in Brazil, where it grows in
cultivated ground and sandy places, or by roadsides, and even in
the less frequented streets of Rio de Janeiro. Authentic specimens
have been forwarded to us by Mr. Glaziou of Rio de Janeiro, and Mr.
J. Correa de Méllo of Campinas; and we have also had ample supplies
of the plant cultivated by us near London and at Strassburg, where
Richardsonia succeeds in the open air.

The root in the fresh state is pure white, but by drying becomes of
a deep iron-grey. In the Brazilian specimens, there is a short crown
emitting as many as a dozen prostrate stems; below this there is
generally, as in true ipecacuanha, a naked woody portion, which extends
downwards into a thicker root, ²/₁₀ of an inch in diameter, and six
or more inches long. This part of the root is marked by deep fissures
on alternate sides, which give it a knotty, sinuous, or undulating
outline. It has a brittle, very thick bark, white and farinaceous
within, surrounding a strong flexible slender woody column. The root
has an earthy odour not altogether unlike that of ipecacuanha, and a
slightly sweet taste. It affords no evidence of emetine when tested
in the manners described at p. 374, and can therefore easily be
distinguished from the true drug.

[1392] Attfield in _Pharm. Journ._ xi. (1870) 140.

[1393] _Journ. de Pharm._ xvi. (1872) 405: xvii. 19.




VALERIANACEÆ.


RADIX VALERIANÆ.

_Valerian Root_; F. _Racine de Valériane_; G. _Baldrianwurzel_.

=Botanical Origin=—_Valeriana officinalis_ L., an herbaceous perennial
plant, growing throughout Europe from Spain to Iceland, the North Cape
and the Crimea, and extending over Northern Asia to the coasts of
Manchuria. The plant is found in plains and uplands, ascending even in
Sweden to 1200 feet above the sea-level.

In England, valerian is cultivated in many villages[1394] near
Chesterfield in Derbyshire, the wild plant which occurs in the
neighbourhood not being sufficiently plentiful to supply the demand.

In Vermont, New Hampshire and New York, as well as in Holland, the
plant is grown to some extent, but by far the largest supply would
appear to be grown in the environs of the German town Cölleda, not far
from Leipzig.

Valerian is propagated by separating the young plants which are
developed at the end of runners emitted from the rootstock.

The wild plant, according to the situation it inhabits, exhibits
several divergent forms. Among eight or more varieties noticed by
botanists,[1395] we may especially distinguish α. _major_ with a
comparatively tall stem and all the leaves toothed, β. _minor_ (_V.
angustifolia_ Tausch) with entire or slightly dentate leaves, and also
_V. sambucifolia_ Mikan, having only 4 or 5 pairs of leaflets.

=History=—The plant which the Greeks and Romans called Φοῦ or _Phu_,
and which Dioscorides and Pliny describe as a sort of wild nard, is
usually held to be some species of valerian.[1396]

The word _Valeriana_ is not found in the classical authors. We first
meet with it in the 9th or 10th century, at which period and for long
afterwards, it was used as synonymous with _Phu_ or _Fu_.

Thus in the writings of Isaac Judæus[1397] occurs the following:—“_Fu
id est valeriana, melior rubea et tenuis et quæ venit de Armenia et est
diversa in sua complexione_....”

Constantinus Africanus[1398]—“_Fu, id est valeriana. Naturam habet
sicut spica nardi_....”

The word _Valeriane_ occurs in the recipes of the Anglo-Saxon leeches
written as early as the 11th century.[1399] _Valeriana_, _Amantilla_
and _Fu_ are used as synonymous in the _Alphita_, a mediæval vocabulary
of the school of Salernum.[1400]

Saladinus[1401] of Ascoli directs (_circa_ A.D. 1450) the collection in
the month of August of “_radices fu id est valerianæ_.”

[1394] Namely Ashover, Woolley Moor, Morton, Stretton, Higham,
Shirland, Pilsley, North and South Wingfield, and Brackenfield. From
the produce of these villages, one wholesale dealer in Chesterfield
obtained in 1872 about 6 tons (13,440 lb.) of root.

[1395] Regel, _Tentamen Floræ Ussuriensis_, 1862 (_Mém. de l’Académie
de St. Pétersbourg_).

[1396] _V. officinalis_ L. and nine other species occur in Asia Minor
(Tehihatcheff).

[1397] _Opera Omnia_, Lugd. 1515, cap. 45.—It must be remembered that
this is a translation from the Arabic. How the word in question stands
in the original we have no means of knowing.

[1398] _De omnibus medico cognitu necessariis_, Basil. 1539. 348.

[1399] _Leechdoms, Wortcunning and Starcraft of early England_, iii.
(1866) 6. 136.

[1400] S. de Renzi, _Collectio Salernitana_, iii. (1854) 271-322.

[1401] _Compendium Aromatariorum_, Bonon. 1488.

Valerian was anciently called in English _Setwall_, a name properly
applied to _Zedoary_; and the root was so much valued for its medicinal
virtues, that as Gerarde[1402] (1567) remarks, the poorer classes
in the north of England esteemed “_no broths, pottage, or physicall
meats_” to be worth anything without it. Its odour, now considered
intolerable, was not so regarded in the 16th century, when it was
absolutely the custom to lay the root among clothes as a perfume[1403]
in the same way as those of _Valeriana celtica_ L. and the Himalayan
valerians are still used in the East.

Some of the names applied to valerian in Northern and Central Europe
are remarkable. Thus in Scandinavia we find _Velandsrot_, _Velamsrot_,
_Vandelrot_ (Swedish); _Vendelród_, _Venderód_, _Vendingsród_
(Norwegian); and _Velandsurt_ (Danish)—names all signifying _Vandels’
root_.[1404] Valerian is also called in Danish _Danmarks græs_. Among
the German-speaking population of Switzerland, a similar word to the
last, namely _Tannmark_, is applied to valerian. The _Denemarcha_
mentioned by St. Hildegard,[1405] about A.D. 1160, is the same. These
names seem to point to some connexion with Northern Europe which we are
wholly unable to explain.

Pentz, a pharmaceutical assistant at Pyrmont, was the first, in 1829,
to draw attention to the acid reaction of the distilled water of
valerian. Another German assistant, Grote, at Verden, showed in 1831
that the acidity was by no means due to acetic acid, but to a peculiar
kind of acid. The latter was identified in 1843 by Dumas with the acid
artificially obtained from amylic alcohol and that extracted in 1817 by
Chevreul from the fat of dolphins.

=Description=—The valerian root of the shops consists of an upright
rhizome of the thickness of the little finger, emitting a few short
horizontal branches, besides numerous slender rootlets.[1406] The
rhizome is naturally very short, and is rendered still more so by the
practice of cutting it in order to facilitate drying. The rootlets,
which are generally 3 to 4 inches long, attain ⅒ of an inch in
diameter, tapering and dividing into slender fibres towards their
extremities. They are shrivelled, very brittle, and, as well as the
rhizome, of a dull, earthy brown. When broken transversely, they
display a dark epidermis, forming part of a thick white bark which
surrounds a slender woody column. The interior of the rhizome is
compact, firm and horny, but when old becomes hollow, a portion of the
tissue remaining however in the form of transverse septa.

The drug has a peculiar, somewhat terebinthinous and camphor-like
odour, and a bitterish, aromatic taste. The root when just taken from
the ground has no distinctive smell, but acquires its characteristic
odour as it dries.

=Microscopic Structure=[1407]—In the rhizome as well as in the
rootlets, the cortical part is separated from the central column by a
dark cambial zone; the medullary rays are not distinctly obvious. In
old rootstocks, sclerenchymatous cells are met with in the cortical
tissue.

[1402] _Herball_, 1636. 1078.

[1403] Turner’s _Herball_, part 3 (1568) 76; Langham, _Garden of
Health_, 1633. 598.

[1404] H. Jenssen-Tusch, _Nordiske Plantenavne_, Kjöbenhavn, 1867. 258.

[1405] _Physica_, Argent. 1533. 62.

[1406] The morphological peculiarities of valerian root are well
explained in Irmisch, _Beitrag zur Naturgeschichte der einheimischen
Valeriana-Arten_, Halle, 1854, 44 pages, 4°, 4 plates.

[1407] The structure of the rhizomes and root of the different species
of valerian has been discussed by Joannes Chatin in his _Etudes sur les
Valérianées_, Paris, 1872, illustrated by 14 beautiful plates.

The parenchyme of the drug is loaded with small starch granules,
brownish grains of tannic matter and drops of essential oil. Numerous
oil ducts are met with in the outer layer of the tissue.

=Chemical Composition=—Volatile oil is contained in the dry root to
the extent of ½ to 2 per cent., yet on an average appears scarcely to
exceed ⁴/₅ per cent. This variation in quantity is partly explained by
the influence of locality, a dry, stony soil yielding a root richer in
oil than one that is moist and fertile. In the latter the plant may be
distinguished as the variety _sambucifolia_, which has a less vigorous
root, devoid of runners.

Schoonbroodt[1408] has shown that the most important influence is the
recent condition of the root. He states that if the root is submitted
to distillation when perfectly fresh, it yields a neutral water and
a large quantity of essential oil. The latter has but a very faint
odour, but by exposure to the air it slowly acidifies, especially if a
little alkali is added, and acquires a strong smell. _Valerianic Acid_
which is thus formed amounts to 6 per mille of the fresh root. The
dried root yields a distillate of decided valerian odour, containing
valerianic acid, but in proportion not exceeding 4 per mille of the
root calculated as fresh.

The oil of valerian is of a very peculiar yellowish or brownish,
sometimes even almost a little greenish hue, and possessing the
characteristic odour of the drug. We found it to deviate the plane
of polarization from 11° to 13° to the left when examined by Wild’s
Polaristrobometer in a column of 50 millimetres. By submitting it to
fractional distillation we noticed[1409] that it affords a magnificent
blue fraction. A superb violet or blue colour is produced if one drop
of the _crude oil_ dissolved in about 20 drops of bisulphide of carbon
is mixed with 1 drop of nitric acid 1·20 sp. gr. Other colorations are
produced if bromine or concentrated sulphuric acid are used;[1410] even
the tincture of valerian displays similar reactions.

Bruylants (1878) has isolated from oil of valerian—1st. A hydrocarbon,
C₁₀H₁₆, boiling at 157° C., yielding a crystallized compound with
HCl. 2nd. The liquid compound C₁₀H₁₈O, which by means of chromic acid
affords common camphor and formic, acetic and valerianic acids, which
are met with in old valerian root, owing no doubt to the slow oxidation
of the compound C₁₀H₁₈O. 3rd. There is also present a crystallizable
compound of the same composition, which is probably identical with
the camphor of Dryobalanops aromatica (see our article on Camphora).
It would appear that this substance is of alcoholic nature, being
combined in the root with the 3 organic acids mentioned under 2nd. On
distilling, these compound ethers are resolved partly into the alcohol
C₁₀H₁₈O (borneol) and the acids. This decomposition is fully performed,
if the root is macerated with alkaline water, and then, on distilling,
a slight excess of sulphuric acid is added. 4th. At about 300° a
greenish portion is coming over, which can be obtained colourless by
again rectifying it. This oil assumes intense colorations if it is
shaken with concentrated mineral acids; it becomes blue by distilling
it over potash.

[1408] _Journ. de Médecine de Bruxelles_, 1867 and 1868;
_Jahresbericht_ of Wiggers and Husemann, 1869. 17.

[1409] _Archiv der Pharmacie_, 209 (1876).

[1410] _Jahresbericht_ of Wiggers and Husemann, 1871. 462.

Valerianic acid as afforded by the root is not agreeing with normal
valerianic acid. It is, more exactly, _isovalerianic acid_, or
isopropyl-acetic acid: (CH₃)₂CH·CH₂COOH, which is produced by Valeriana
as well as by Archangelica officinalis and Viburnum Opulus. The same
acid also may be obtained from the fat of Dolphinus globiceps.

After the root has been submitted to the distillation of the oil, there
is found a strongly acid residue containing malic acid, resin, and
sugar,—the last capable, according to Schoonbroodt, of reducing cupric
oxide.

=Uses=—Valerian is employed as a stimulant and antispasmodic.

=Substitutes=—In the London market there has been offered “_Kesso_” the
root of _Patrinia scabiosaefolia_ Link,[1411] a Japanese herb of the
order Valerianaceæ. This drug consists of a very short rootstock giving
off a large number of rootlets about 5 inches long and ⅒ of an inch
in diameter. By the absence of a well-marked upright rhizome in this
_Japanese Valerian_ it is widely differing from our Valerian, although
at first sight it agrees to some extent with it. As to the odour and
taste we find Kesso almost identical with true Valerian.

The less aromatic and now disused root of _Valeriana Phu_ L. consists
of a thicker rhizome which lies in the earth obliquely; it is less
closely annulated and rooted at the bottom only. It resembles by no
means true Valerian.

[1411] According to Holmes, _Ph. J._ x. (1879) 22.




COMPOSITÆ.


RADIX INULÆ.

_Radix Enulæ_, _Radix Helenii_; _Elecampane_;[1412] F. _Racine
d’Aunée_; G. _Alantwurzel_.

=Botanical Origin=—_Inula Helenium_ L.—This stately perennial plant
is very widely distributed, occurring scattered throughout the
whole of central and southern Europe, and extending eastward to the
Caucasus, Southern Siberia and the Himalaya. It is found here and there
apparently wild in the south of England and Ireland, as well as in
Southern Norway and in Finland (Schübeler).

Elecampane was formerly cultivated in gardens as a medicinal and
culinary plant, and in this manner has wandered to North America. In
Holland and some parts of England and Switzerland, it is cultivated on
a somewhat larger scale, most largely probably near Cölleda (see p.
377).

[1412] A corruption of _Enula Campana_, the latter word referring to
the growth of the plant in Campania (Italy).

=History=—The plant was known to the ancient writers on agriculture
and natural history, and even the Roman poets were acquainted with it,
and mention Inula as affording a root used both as a medicine and a
condiment. Vegetius Renatus, about the beginning of the 5th century,
calls it Inula Campana, and St. Isidore in the beginning of the 7th
names it as _Inula_, adding—“quam _Alam_ rustici vocant.” It is
frequently mentioned in the Anglo-Saxon writings on medicine current
in England prior to the Norman Conquest; it is also the “marchalan” of
the Welsh Physicians[1413] of the 13th century and was generally well
known during the middle ages. Not only was its root much employed as a
medicine, but it was also candied and eaten as a sweetmeat.

=Description=—For pharmaceutical use, the root is taken from plants
two or three years old; when more advanced, it becomes too woody. The
principle mass of the root is a very thick short crown, dividing below
into several fleshy branches of which the larger are an inch or two
in diameter, covered with a pale yellow bark, internally whitish, and
juicy. The smaller roots are dried entire; the larger are variously
sliced, which occasions them to curl up irregularly. When dried, they
are of a light grey, brittle, horny, smooth-fractured. Cut transversely
the young root exhibits an indistinct radiate structure, with a
somewhat darker cambial zone separating the thick bark from the woody
nucleus. The pith is not sharply defined, and is often porous and
hollow. In the older roots the bark is relatively much thinner, and
the internal substance is nearly uniform. Elecampane root has a weak
aromatic odour suggestive of orris and camphor, and a slightly bitter,
not unpleasant, aromatic taste.

=Microscopic Structure=—The medullary rays, both of the woody
column and the inner part of the bark (_endophlœum_), exhibit large
balsam-ducts. In the fresh root they contain an aromatic liquid, which
as it dries deposits crystals of helenin, probably derived from the
essential oil. The parenchymatous cells of the drug are loaded with
inulin in the form of splinter-like fragments, devoid of any peculiar
structure.

=Chemical Composition=—It was observed by Le Febvre, as early as 1660,
that when the root of elecampane is subjected to distillation with
water a crystallizable substance collects in the head of the receiver
from which it speedily passes on as the operation proceeds. Similar
crystals may also be observed after carefully heating a thin slice
of the root, and are even found as a natural efflorescence on the
surface of root that has been long kept. They can be extracted from the
root by means of alcohol and precipitated with water. Kallen (1874,
1876) showed that the crystals chiefly consist of the _anhydride_,
C₁₅H₂₀O₂, of _alantic acid_, melting at 66° C. The anhydride, which is
very little aromatic, can easily be sublimed, although it begins to
boil only at 275°, yet not without decomposition. Alantic anhydride
dissolves in caustic lye, but on saturating the solution with an acid,
alantic acid, C₁₅H₂₂O₃, separates. It is not present in the root.

The anhydride is accompanied by a small quantity of _Helenin_, C₆H₈O,
and _Alantcamphor_ (i.e. Elecampane-camphor). The crystals of helenin
have a slightly (?) bitterish taste, but no odour, and melt at 110°.
The camphor, occurring in but very small amount, has not yet been
analyzed; it agrees probably with the formula C₁₀H₁₆O; it melts at
64° C., and in taste and smell is suggestive of peppermint. It is
very difficult entirely to remove helenin from alantcamphor, these
substances being soluble to nearly the same extent in alcohol or ether.
By distilling the second of them with pentasulphide of phosphorus,
_Cymene_, C₁₀H₁₄, was obtained.

[1413] _Meddygon Myddfai_, p. 61. 284. 311 (see Appendix).

By distilling the root under notice with water, the alantic anhydride
is chiefly obtained, but impregnated with _Alantol_, C₁₀H₁₆O
(probably). The latter can be removed from the crystals by pressing
them between folds of bibulous paper. On submitting this again to
distillation, alantol is obtained as an aromatic liquid, boiling at
200°.

The substance most abundantly contained in elecampane root is _Inulin_,
discovered in it by Valentine Rose at Berlin in 1804. It has the same
composition as starch, C₆H₁₀O₅, but stands to a certain extent in
opposition to that substance, which it replaces in the root-system of
_Compositæ_. In living plants, inulin is dissolved in the watery juice,
and on drying is deposited within the cells in amorphous masses, which
in polarized light are inactive, and are not coloured by iodine. There
are various other characters, by which inulin differs from starch. Thus
for instance, inulin readily dissolves in about 3 parts of boiling
water; the solution is perfectly clear and fluid, not paste-like; but
on cooling deposits nearly all the inulin. The solution is levogyre and
is easily transformed into uncrystallizable sugar. With nitric acid,
inulin affords no explosive compound as starch does.

Sachs showed in 1864 that by immersing the roots of elecampane, or
_Dahlia variabilis_ or of many other perennial _Compositæ_, in alcohol
or glycerin, inulin may be precipitated in a crystalline form. Its
globular aggregates of needle-shaped crystals (“sphæro-crystals”)
then exhibit under the polarizing microscope a cross similar to that
displayed by starch grains.

The amount of inulin varies according to the season, but is most
abundant in the autumn. Of the various sources for it, the richest
appears to be elecampane. Dragendorff, who has made it the subject of a
very exhaustive treatise,[1414] obtained from the root in October not
less than 44 per cent., but in spring only 19 per cent.

In the roots of the _Compositæ_ inulin is accompanied, according to
Popp,[1415] by two closely allied substances, _Synanthrose_, C₁₂H₂₂O₁₁
+ H₂O, and _Inuloïd_, C₆H₁₀O₅ + H₂O. Synanthrose is soluble in dilute
alcohol, devoid of any rotatory power, and deliquescent. Inuloïd is
much more readily soluble in water than inulin. Both these substances
are probably present in elecampane.

Inulin is widely distributed in the perennial roots of compositæ, and
has also been met with in the natural orders Campanulaceæ, Goodenovieæ
(or Goodeniaceæ), Lobeliaceæ, Stylidieæ, and lastly by Kraus (1879) in
the root of _Ionidium Ipecacuanha_ St. Hilaire, Violaceæ; the formerly
so-called _Ipecacuanha alba lignosa_ (see p. 375, note 4).

=Uses=—Elecampane is an aromatic tonic, but as a medicine is now
obsolete. It is chiefly sold for veterinary practice. In France
and Switzerland (Neuchâtel), it is employed in the distillation of
_Absinthe_.

=Substitutes=—Dioscorides in speaking of _Costus_ root states that it
is often mixed with that of elecampane of Kommagene (north-western
Syria). The former, derived from _Aplotaxis[1416] auriculata_ DC. (_A.
Lappa_ Decaisne, _Aucklandia Costus_ Falconer), is remarkably similar
to elecampane both in external appearance and structure. Costus is an
important spice, incense and medicine in the east from the antiquity
down to the present day;[1417] it would be of great interest to examine
it chemically with regard to elecampane.

[1414] _Materialien zu einer Monographie des Inulins_, St. Petersburg,
1870. 141 pages—See also _Prantl’s_ paper on Inulin, as abstracted in
_Pharm. Journ._ Sept. 1871. 262.

[1415] Wiggers and Husemann, _Jahresbericht_ for 1870. 68.

[1416] Bentham and Hooker unite this plant with _Saussurea_.

[1417] See Cooke, _Pharm. Journ._ viii. (1877) 41; Flückiger, _ibid._
121.


RADIX PYRETHRI.

_Pellitory Root_, _Pellitory of Spain_; F. _Pyrèthre-salivaire_; G.
_Bertramwurzel_.

=Botanical Origin=—_Anacylus Pyrethrum_ DC. (_Anthemis Pyrethrum_ L.),
a low perennial plant with small, much divided leaves, and a radiate
flower resembling a large daisy. It is a native of northern Africa,
especially Algeria, growing on the high plateaux that intervene between
the fertile coast regions and the desert.

=History=—The πύρεθρον of Dioscorides was an umbelliferous plant, the
determination of which must be left to conjecture. The pellitory of
modern times was familiar to the Arabian writers on medicine, one of
whom, Ibn Baytar, describes it very correctly from specimens gathered
by himself near the city of Constantine in Algeria. The plant, says
he, called by the Berbers _sandasab_, is found nowhere but in Western
Africa, from which region it is carried to other countries.[1418]

Pellitory root is a favourite remedy in the East, and has long been
an article of export by way of Egypt to India. An Arabic name for
it is _Aāqarqarhā_ or _Akulkara_[1419], a word which, under slight
variations, is found in the principal languages of India. In Germany,
pellitory was known as early as the 12th century; it is named in the
oldest printed works on materia medica. In the 13th century “pellitory
of _Spain_” (Pelydr ysbain) was a proved “remedy for the toothache”
with the Welsh physicians.[1420]

=Description=—The root as found in the shops is simple, 3 to 4 inches
long by ⅜ to ⁴/₈ of an inch thick, cylindrical, or tapering, sometimes
terminated at top by the bristly remains of leaves, and having only
a few hair-like rootlets. It has a brown, rough, shrivelled surface,
is compact and brittle, the fractured surface being radiate and
destitute of pith. The bark, at most ¹/₂₅ of an inch thick, adheres
closely to the wood, a narrow zone of cambium intervening. The woody
column is traversed by large medullary rays in which, as in the bark,
numerous dark resin-ducts are scattered. The root has a slight aromatic
smell, and a persistent, pungent taste, exciting a singular tingling
sensation, and a remarkable flow of saliva. The drug is very liable to
the attacks of insects.

=Microscopic Structure=—The cortical part of this root is remarkable on
account of its suberous layer, which is partly made up of sclerenchyme
(thick-walled cells). Balsam-ducts (oil-cells) occur as well in
the middle cortical layer as in the medullary rays. Most of the
parenchymatous cells are loaded with lumps of inulin; pellitory in fact
is one of those roots most abounding in that substance.

[1418] Sontheimer’s translation, ii. (1842) 179.

[1419] _Haq’recarcha_; see Steinschneider, in Rohlfs’ Archiv für
Geschichte der Medicin (1879) 342.

[1420] _Meddygon Myddfai_ (see Appendix) 184. 292. 374.

=Chemical Composition=—Pellitory has been analysed by several chemists,
whose labours have shown that its pungent taste is due in great part
to a resin, not yet fully examined. The root also contains a little
volatile oil besides, sugar, gum, and a trace of tannic acid. The
so-called _Pyrethrin_ is a mixed substance.

=Commerce=—The root is collected chiefly in Algeria and is
exported from Oran and to a smaller extent from Algiers. But from
the information we have received from Colonel Playfair, British
Consul-General for Algeria, and from Mr. Wood, British Consul at Tunis,
it appears that the greater part is shipped from Tunis to Leghorn
and Egypt. Mr. Wood was informed that the drug is imported from the
frontier town of Tebessa in Algeria into the regency of Tunis, to the
extent of 500 _cantars_ (50,000 lb.) per annum.

Bombay imported in the year 1871-72, 740 cwt. of this drug, of which
more than half was shipped to other ports of India.[1421]

=Uses=—Chiefly employed as a sialogogue for the relief of toothache,
occasionally in the form of tincture as a stimulant and rubefacient.

=Substitute=—In Germany, Russia and Scandinavia, African pellitory
is replaced by the root of _Anacyclus officinarum_ Hayne, an annual
herb long cultivated in Prussia and Saxony.[1422] Its root of a light
grey is only half as thick as that of _A. Pyrethrum_, and is always
abundantly provided with adherent remains of stalks and leaves. It is
quite as pungent as that of the perennial species.


FLORES ANTHEMIDIS.

_Chamomile Flowers_; F. _Fleurs de Camomille Romaine_; G. _Römische
Kamillen_.

=Botanical Origin=—_Anthemis nobilis_ L., the Common or Roman
Chamomile, a small creeping perennial plant, throwing up in the latter
part of the summer solitary flowerheads.

It is abundant on the commons in the neighbourhood of London, and
generally throughout the south of England; and extends to Ireland, but
is not a native of Scotland, except the islands of Bute and Cumbrae,
where Anthemis is stated to grow wild. It is plentiful in the west and
centre of France, Spain, Portugal, Italy, and Dalmatia; and occurs as a
doubtful native in Southern and Central Russia.

=History=—The identification of the chamomile in the classical and
other ancient authors seems to be impossible, on account of the large
number of allied plants having similar inflorescence.

The chamomile has been cultivated for centuries in English gardens, the
flowers being a common domestic medicine. The double variety was well
known in the 16th century.

The plant was introduced, according to Gesner, into Germany from
Spain about the close of the middle ages. Tragus first designated it
_Chamomilla nobilis_,[1423] and Joachim Camerarius (1598), who had
observed its abundance near Rome, gave it the name of _Roman Chamomile_.

[1421] _Statement of the Trade and Navigation of the Presidency of
Bombay_ in 1871-72, pt. ii. 19. 98.

[1422] For further information on the medicinal species of _Anacyclus_,
see a paper by Dr. P. Ascherson in _Bonplandia_, 15 April 1858.

[1423] _De Stirpium_ ..., 1552. 149.—In Germany the epithet _edel_ (=
_nobilis_) is frequently used in popular botany to designate useful or
remarkable plants. Tragus may have been induced to bestow it on the
species under notice, on account of its superiority to _Matricaria
Camomilla_, the so-called _Common Chamomile_ of the Germans.

Porta, about the year 1604,[1424] states that 100 pounds of _Flores
Chamœmeli_ yielded 2 drachmæ of a green volatile oil; we suppose he
distilled the flowers under notice.

=Production=—The camomile is cultivated at Mitcham, near London, the
land applied to this purpose being in 1864 about 55 acres, and the
yield reckoned at about 4 cwt. per acre. The flowers are carefully
gathered, and dried by artificial heat; and fetch a high price in the
market.[1425]

The plant is grown on a large scale at Kieritzsch, between Leipzig and
Altenburg, and near Zeiz and Borna, all in Saxony; and likewise to some
extent in Belgium and France.

=Description=—The chamomile flowers found in commerce are never those
of the wild plant, but are produced by a variety in which the tubular
florets have all, or for the greater part been converted into ligulate
florets. In the flowers of some localities this conversion has been
less complete, and such flowers having a somewhat yellow centre, are
called by druggists _Single Chamomiles_; while those in which all the
florets are ligulate and white, are known as _Double Chamomiles_.

Chamomile flowers have the general structure found in the order
_Compositæ_. They are ½ to ¾ of an inch across, and consist of a
hemispherical involucre about ⅜ of an inch in diameter, composed of a
number of nearly equal bracts, scarious at the margin. The receptacle
is solid, conical, about ¼ of an inch in height, beset with thin,
concave, blunt, narrow, chaffy scales, from the bases of which grow the
numerous florets. In the wild plant, the outer of these, to the number
of 12 or more, are white, narrow, strap-shaped, and slightly toothed
at the apex. The central or disc florets are yellow and tubular, with
a somewhat bell-shaped summit from which project the two reflexed
stigmas. In the cultivated plant, the ligulate florets predominate, or
replace entirely the tubular. The florets which are wholly destitute of
pappus are reflexed, so that the capitulum when dried has the aspect
of a little white ball. Minute oil-glands are sparingly scattered
over the tubular portion of the florets of either kind. The flowers
of chamomile, as well as the green parts of the plant, have a strong
aroma, and a very bitter taste.

In trade, dried chamomile flowers are esteemed in proportion as they
are of large size, very double, and of a good white—the last named
quality being due in great measure to fine dry weather during the
flowering period. Flowers that are buff or brownish, or only partially
double, command a lower price.

=Chemical Composition=—Chamomile flowers yield from 0·6 to 0·8 per
cent. of essential oil,[1426] which is at first of a pale blue, but
becomes yellowish-brown in the course of a few months.

At Mitcham, oil of chamomile is usually distilled from the _entire
plant_, after the best flowers have been gathered. The oil has a shade
of green, to remove which it is exposed to sunlight; it thus acquires a
brownish-yellow colour, at the same time throwing down a considerable
deposit.

[1424] _De distillatione_, Romæ, 1608. 83.

[1425] About £9 per cwt., Foreign Chamomiles being worth from £3 to £4.

[1426] Information obligingly given by Messrs. Schimmel & Co., Leipzig.
The oil distilled by them was examined in Prof. Fittig’s laboratory,
Strassburg.

The investigations of several chemists, performed in 1878-79 in
Fittig’s laboratory, have shown the oil to contain the following
constituents:—At 147-148° C. _isobutylic ethers_ and hydrocarbons
are distilling, at 177° _angelicate_ of _isobutyl_, at 200°-201°
_angelicate_ of _isamyl_, at 204°-205° _tiglinate_ of _isamyl_ (both
these compound ethers answering to the formula C₅H₇O·OC₅H₁₁). In the
residual portion hexylic alcohol, C₆H₁₃OH, and an alcohol of the
formula C₁₀H₁₆O, are met with, both probably occurring in the form
of compound ethers. By decomposing the angelicates and the tiglinate
above named with potash, angelic acid, C₅H₈O₂, and tiglinic (or
methylcrotonic) acid, isomeric to the former, are obtained to the
extent of about 30 or more per cent. of the crude oil. In the oil
examined by Fittig, angelic acid was prevailing; from another specimen
E. Schmidt (1879) obtained but very little of it, tiglinic acid was by
far prevailing (see also article Oleum Crotonis).

We have performed some experiments in order to isolate the _bitter
principle_, but have not succeeded in obtaining it in a satisfactory
state of purity; it forms a brown extract, apparently a glucoside. We
can also confirm the statement that no alkaloid is present.

=Uses=—An infusion or an extract of chamomile is often used as a bitter
stomachic and tonic.

=Adulteration and Substitution=—The flowerheads of _Matricaria
Chamomilla_ L., designated in Germany _Common Chamomiles_ (_gemeine
Kamillen_), are sometimes asked for in this country. In aspect as well
as in odour, they are very different from the chamomiles of English
pharmacy; they are quite single, not bitter, and have the receptacle
devoid of scales and hollow.

A cultivated variety of _Chrysanthemum Parthenium_ Pers., or Feverfew,
with the florets all ligulate, and some scales on the receptacle
(not having the receptacle _naked_, as in the wild form), common in
gardens,[1427] has flowerheads exceedingly like double chamomiles. But
they may be distinguished from the latter by their _convex_ or _nearly
flat_ receptacle, with the scales lanceolate and acute, and less
membranous.

The chamomiles of the Indian bazaars which are brought from Persia
and known as _Bābūnah_, are (as we infer from the statement of Royle)
the flowers of _Matricaria suaveolens_ L., a slender form of _M.
Chamomilla_, growing in Southern Russia, Persia, Southern Siberia, also
in North America.

The fresh wild plant of _Anthemis nobilis_ L., pulled up from the
ground, is sold in London for making extract, a proceeding highly
reprehensible supposing the extract to be sold for medicinal use.

[1427] Is not this plant the _Anthemis? parthenioides_ Bernh., of which
De Candolle says (_Prod._ vi. 7)—“ ... simillima _Mat. Parthenio_, sed
paleis inter flores instructa. Ferè semper plena in hortis occurrit,
et forte ideo paleæ receptaculi ex luxuriante statu ortæ ut in
_Chrysanthemi indico et sinensi_ ...”?


SANTONICA.

    _Flores Cinæ_, _Semen Cinæ_,[1428] _Semen
        Santonicæ_, _Semen Zedoariæ_, _Semen
        Contra_, _Semen Sanctum_; _Wormseed_; F.
        _Semen-contra_, _Semencine_, _Barbotine_;
        G. _Wurmsamen_, _Zitwersamen_.

=Botanical Origin=—_Artemisia maritima_, var. _a. Stechmanniana_
Besser[1429] (_A. Lercheana_ Karel. et Kiril, in Herbb. Kew, et Mus.
Brit.; _A. maritima_ var. _a. pauciflora_ Weber, quoad Ledebour, _Flor.
Ross._ ii. 570).

_Artemisiæ_ of the section _Seriphidium_ assume great diversity of
form:[1430] they have been the object of attentive study on the part
of the Russian botanists Besser (1834-35) and Ledebour (1844-46),
whose researches have resulted in the union of many supposed species,
under the head of the Linnæan _Artemisia maritima_. This plant has
an extremely wide distribution in the northern hemisphere of the old
world, occurring mostly in saltish soils. It is found in the salt
marshes of the British Islands, on the coasts of the Baltic, of France
and the Mediterranean, and on saline soils in Hungary and Podolia;
thence it extends eastward, covering immense tracts in Southern Russia,
the regions of the Caspian, and Central Siberia, to Chinese Mongolia.

The particular variety which furnishes at least the chief part of the
drug, is a low, shrubby, aromatic plant, distinguished by its very
small, erect, ovoid flowerheads, having oblong, obtuse, involucral
scales, the interior scales being scarious. The stem in its upper
half is a fastigiate, thyrsoid panicle, crowned with flowerheads. The
localities for the plant are the neighbourhood of the Don, the regions
of the lower Volga near Sarepta and Zaritzyn, and the Kirghiz deserts.

The drug, which consists of the minute, unopened flowerheads, is
collected in large quantities, as we are informed by Björklund (1867),
on the vast plains or steppes of the Kirghiz, in the northern part of
Turkestan. It was formerly gathered about Sarepta, a German colony in
the Government of Saratov, but from direct information we have (1872)
received, it appears to be obtained there no longer.

The emporium for wormseed is the great fair of Nishnei-Novgorod
(July 15th to Aug. 27th), whence the drug is conveyed to Moscow, St.
Petersburg, and Western Europe.

Wormseed is found in the Indian bazaars. A specimen received by us from
Bombay does not materially differ in form from the Russian drug, but is
slightly shaggy and mixed with tomentose stalks. It is probably brought
from Afghanistan and Cabul.[1431]

Wilkomm[1432] has described, as mother plant of wormseed, an
_Artemisia_ which he calls _A. Cina_. It was obtained in Turkestan
by Prof. Petzholdt, who received it from the people gathering the
drug. The specimen kindly communicated to us by Prof. Willkomm has
flowerheads which do not entirely resemble the wormseed of trade, in
that they have fewer scales, but their number may be somewhat varying.

[1428] From the Italian _semenzina_, the diminutive of _semenza_ (seed).

[1429] W. S. Besser in _Bulletin de la Soc. imp. des Naturalistes de
Moscou_, vii. (1834) 31.—A specimen of the plant in question labelled
in Besser’s handwriting, with a memorandum that it is collected for
medicinal use, is in the Herbarium of the Royal Gardens, Kew. It
completely agrees with the _Semen Cinæ_ of Russian and German commerce.
This remark also applies to a specimen of _A. Lercheana_ Karel. et
Kiril. in the same herbarium.

[1430] “Si aliæ Artemisiæ multùm variant, Seriphidia inconstantiâ
formarum omnes superant....”—Besser.

[1431] _Artemisia_ No. 3201, Herb. Griffith, Afghanistan, in the Kew
Herbarium has capitules precisely agreeing with this Bombay drug.

[1432] _Bot. Zeitung_, 1 März 1872. 130; _Pharm. Journ._ 23 March 1872.
772 (abstract).

=History=—Several species of _Absinthium_ are mentioned by Dioscorides,
one of which called Ἀψίνθιον Θαλάσσιον or Σέριϕον, having very small
seeds (capitules), and growing in Cappadocia, he states to be taken
in honey as a remedy for ascarides and lumbrici: one can hardly doubt
but that this is the modern wormseed. Another species is described by
the same author as being called Σαντόνιον, from its growing in the
country of the Santones in Gaul (the modern Saintonge); he asserts it
to resemble σέριϕον in its properties.

In an epistle on intestinal worms attributed to Alexander
Trallianus,[1433] who practised medicine with great success at Rome in
the 6th century, the use is recommended of a decoction of _Absinthium
marinum_ (θαλασσία ἀψίνθη) as a cure for ascarides and round worms.

_Semen sanctum vel Alexandrinum_ is mentioned as a vermifuge for
children by Saladinus about A.D. 1450, and by Ruellius, Dodonæus,
the Bauhins, and other naturalists of the 16th century. Tragus[1434]
mentions that it is imported by way of Genoa. Its ancient reputation
has been fully maintained in modern times, and in the form partly of
_Santonin_, the drug is still extensively employed.

=Description=—Good samples of the drug consist almost exclusively of
entire, unopened flowerheads or capitules, which are so minute that
it requires about 90 to make up the weight of one grain. In samples
less pure, there is an admixture of stalks, and portions of a small
pinnate leaf. The flowerheads are of an elliptic or oblong form, about
⅒ of an inch long, greenish yellow when new, brown if long kept; they
grow singly, less frequently in pairs, on short stalks, and are formed
of about 18 oblong, obtuse, concave scales, closely imbricated. This
involucre is much narrowed at the base in consequence of the lowermost
scales being considerably shorter than the rest. The capitule is
sometimes associated with a few of the upper leaves of the stem, which
are short, narrow, and simple. Notwithstanding its compactness, the
capitule is somewhat ridged and angular,[1435] from the involuclar
scales having a strong, central nerve or keel. The middle portion of
each scale is covered with minute, yellow, sessile glands, which are
wanting on the transparent scarious edge. The latter is marked with
extremely fine striæ and is quite glabrous; in the young state the
keel bears a few woolly colourless hairs, but at maturity the whole
flowerhead is shining and nearly glabrous.[1436] The florets number
from 3 to 5; they have (in the bud) an ovoid corolla, glandular in its
lower portion, a little longer than the ovary, which is destitude of
pappus.

[1433] Contained in a work by Hieronymus Mercurialis, entitled
_Variarum Lectionum libri quatuor_, Venet. 1570; also in Puschmann’s
edition of _Alexander_ (see Appendix), i. 238. 240.

[1434] In Brunfels (_De vera herbarum cognitione_), Argentorati, 1531.
196.

[1435] Maceration in water, which restores the natural shape of the
flowerheads, shows that this shrunken, angular form is not found in the
growing plant.

[1436] Yet too much stress must not be laid on this character, for
as Besser remarks—“_periclinii squamæ in uno loco tomento brevi plus
minusve canæ, in aliis nudæ, imo nitidæ_.”

Wormseed when rubbed in the hand exhales a powerful and agreeable
odour, resembling cajuput oil and camphor; it has a bitter aromatic
taste.

=Chemical Composition=—Wormseed yields from 1 to 2 per cent. of
essential oil, having its characteristic smell and taste. The oil
is slightly levogyrate and chiefly consists of the liquid C₁₀H₁₈O,
accompanied by a small amount of hydrocarbon. The former has the odour
of the drug, yet rather more agreeable; sp. gr. 0·913 at 20° C. It
boils without decomposition at 173°-174°, but in presence of P₂O₅ or
P₂S₅ abundantly yields cymol (see p. 333). The latter had already been
observed by Völckel (1854) under the name of _cinene_ or _cynene_, yet
he assigned to it the formula C₁₂H₉; Hirzel (1854) called it cinæbene.

The water which distills over carries with it volatile acids of the
fatty series, also _angelic acid_ (see pp. 313, 386).

The substance to which the remarkable action of wormseed on the human
body[1437] is due is _Santonin_, C₁₅H₁₈O₃. It was discovered in 1830 by
Kahler, an apothecary of Düsseldorf, who gave a very brief notice of
it in the _Archiv der Pharmacie_ of Brandes (xxxiv. 318). Immediately
afterwards Augustus Alms, a druggist’s assistant at Penzlin in the
grand duchy of Mecklenburg-Schwerin, knowing nothing of Kahler’s
discovery, obtained the same substance and named it _Santonin_. Alms
recommended it to the medical profession, pointing out that it is the
anthelminthic principle of wormseed.[1438] Santonin constitutes from 1½
to 2 per cent. of the drug, but appears to diminish in quantity very
considerably as the flowers open. It is easily extracted by milk of
lime, for, though not an acid and but sparingly soluble in water even
at a boiling heat, it is capable of combining with bases. With lime it
forms then santoninate of calcium, which is readily soluble in water.
On addition of hydrochloric acid, santoninic acid, C₁₅H₂₀O₄, separates,
but parts with OH₂, santonin being thus immediately reproduced. Similar
facts have been recorded with regard to alantic acid (see p. 381).

Santonin forms crystals of the orthorhombic system, melting at 170°,
which are inodorous, but have a bitter taste, especially when dissolved
in chloroform or alcohol.[1439] They are colourless, but when exposed
to daylight, or to the blue or violet rays, but not to the other
colours of the spectrum, they assume a yellow hue, and split into
irregular fragments. This change, which takes place even under water,
alcohol or ether, is not accompanied by any chemical alteration.
This behaviour of santonin when exposed to light, resembles that of
erythrocentaurin, C₂₇H₂₄O₈. The latter has been obtained by means of
ether, from the alcoholic extract of _Erythræa Centaurium_, and of
some other _Gentianaceæ_. Méhu (1866) has shown that the colourless
crystals of that substance when exposed to sunlight, assume a
brilliant red colour, _without_ undergoing any chemical alteration.
The _colourless_ solutions of this body in chloroform or alcohol yield
the original substance. Yet as to santonin, Sestini and Cannizzaro
(1876) have shown, that its dilute alcoholic solution, on long exposure
to sunlight, affords a compound ether of photosantonic acid, namely
C₁₅H₁₃O₄(C₂H₅)₂.

[1437] As the affected vision, so that objects appear as if seen
through a yellow medium. Other effects are recorded by Stillé
(_Therapeutics and Mat. Med._ ii. 641).

[1438] The paper of Alms being contained in the very same periodical
(p. 319) as that of Kahler (and further in vol. xxxix. 190), affords
additional evidence of the independence of the discovery.

[1439] Its ready solubility in 3 or 4 parts of chloroform renders its
estimation easy when mixed with sugar, as in a santonin lozenge.

Wormseed contains, in addition to the above described bodies, resin,
sugar, waxy fat, salts of calcium and potassium, and malic acid; when
carefully selected and dried, it yielded us 6·5 per cent. of ash, rich
in silica.

=Commerce=—Ludwig of St. Petersburg has stated that the imports of
wormseed into that city were about as follows:—In 1862, 7400 cwt.; in
1863, 10,500 cwt.; in 1864, 11,400 cwt. The drug was brought from the
Kirghiz steppes by Semipalatinsk and by Orenburg.

=Uses=—The drug is employed exclusively for its anthelminthic
properties, partly in the form of santonin. It proves of special
efficacy for the dislodgement of _Ascaris lumbricoides_.


RADIX ARNICÆ.

_Rhizoma Arnicæ_, _Arnica Root_; F. _Racine d’Arnica_; G.
_Arnicawurzel_.

=Botanical Origin=—_Arnica montana_ L., a perennial plant growing in
meadows throughout the northern and central regions of the northern
hemisphere, but not reaching the British Islands. In western and
central Europe it is an inhabitant of the mountains, but in colder
countries it grows in the plains.

In high latitudes, as in Arctic Asia and America, a peculiar form of
the plant distinguished by narrow, almost linear leaves has been named
_A. angustifolia_ Vahl; but numerous transitional forms prove its
identity with the ordinary _A. montana_ of Europe.

=History=—The older botanists as Matthiolus, Gesner, Camerarius,
Tabernæmontanus, and Clusius were acquainted with Arnica and had some
knowledge of its medicinal powers, which appear to have been expressly
recommended, towards the end of the 16th century, by Franz Joël,
professor of Greifswald, Germany.[1440] All parts of the plant were no
doubt popular remedies in Germany at an early period, but Arnica was
only introduced into regular medicine on the recommendation of Johann
Michael Fehr of Schweinfurt and of several other physicians.[1441] But
for enthusiastic laudation of the new remedy, all these writers fall
far short of Collin of Vienna, who imagined that in Arnica he had found
a European plant possessing all the virtues of Peruvian Bark.[1442] In
his hands fevers and agues gave way under its use, and more than 1000
patients in the Pazman Hospital were alleged to have been cured of
intermittents by an electuary of the flowers, between 1771 and 1774.
Such happy results were not obtained by other physicians.

[1440] Sprengel, _Geschichte der Arzneykunde_, iv. (1827) 546.

[1441] Fehr, _De Arnica lapsorum panacea, in Ephemerid. nat. cur._
Dec. 1, (1678, 1679) No. 2. p. 22 (“usus est in _radice_, _foliis_ et
_floribus_”).—G. A. de la Marche, _Dissertatio_, Halæ Magdeburg, 1744.

[1442] Heinrich Joseph Collin, _Heilkräfte des Wolverley_, Breslau,
1777 (translation); also _Arnicæ, in febribus et aliis morbis putridis
vires_,—in the _Anni Medici_ of Störck and Collin, ed. nov., Amstel.,
iii. (1779) 133.

Arnica (_herba_, _flos_, _radix_) had a place in the London
Pharmacopœia of 1788, but it soon fell out of notice, so that Woodville
writing in 1790, remarks that he had been unable to procure the
plant from any of the London druggists. Of late years it has gained
some popular notoriety as an application in the form of tincture,
for preventing the blackness of bruises, but in England it is rarely
prescribed internally.

=Description=—The arnic root of pharmacy consists of a slender,
contorted, dark brown rootstock, an inch or two long, emitting from its
under side an abundance of wiry simple roots, 3, 4 or more inches in
length; it usually bears the remains of the rosette of characteristic,
ovate, coriaceous leaves, which are 3-to 5-nerved, ciliated at the
margin, and slightly pubescent on their upper surface. It has a faintly
aromatic, herby smell, and a rather acrid taste.

=Microscopic Structure=—On a transverse section, the rootstock exhibits
a large pith surrounded by a strong woody ring. In the innermost part
of the cortical layer, large oil-ducts are found corresponding to the
fibro-vascular bundles. Neither starch granules, inulin, or oxalate
of calcium are visible in the tissue. The rootlets are of a different
structural character, but also contain oil-ducts.

=Chemical Composition=—Several chemists have occupied themselves
in endeavouring to isolate the active principle of arnica. Bastick
described (1851) a substance which he obtained in minute quantity from
the flowers and named _Arnicine_. He states it to possess alkaline
properties, to be non-volatile, slightly soluble in water, more so in
alcohol or ether; when neutralized with hydrochloric acid, it forms a
crystalline salt.

The _Arnicin_ extracted by Walz (1861) both from the root and flowers
of arnica is a different substance; it is an amorphous yellow mass of
acrid taste, slightly soluble in water, freely in alcohol or ether,
and dissolving also in alkaline solutions. It is precipitable from its
alcoholic solution by tannic acid or by water. Walz assigns to arnicin
the formula C₂₀H₃₀O₄; other chemists that of C₃₅H₅₄O₇. Arnicin has not
yet been proved a glucoside, although it is decomposed by dilute acids.

Sigel (1873) obtained from dried arnica root about ½ per cent.
of essential oil, and 1 per cent. from the fresh; the oil of the
latter had a sp. gr. of 0·999 at 18° C. The oil was found to be a
mixture of various bodies, the principle being _dimethylic ether of
thymohydroquinone_

           {OCH₃
    C₁₀H₁₂ {     , boiling at about 235°.
           {OCH₃

The water from which the oil separates contains _isobutyric acid_,
probably also a little _angelic_ and _formic acid_; but neither
capronic nor caprylic acid, which had been pointed out by Walz.

Arnica root contains _inulin_, which Dragendorff extracted from it to
the extent of about 10 per cent.

=Uses=—Arnica is used chiefly in the form of tincture as a popular
application to bruises and chilblains; internally it is occasionally
prescribed as a stimulant and diaphoretic.

=Adulteration=—Arnica root has been met with[1443] adulterated with
the root of _Geum urbanum_ L., a common herbaceous plant of the order
_Rosaceæ_. The latter is thicker than the rhizome of arnica, being
³/₁₀ to ⁴/₁₀ of an inch in diameter; it is a true _root_, furnished on
all sides with rootlets, and has an _astringent_ taste. The leaves of
_Geum_ are pinnate and quite unlike those of arnica.

[1443] Holmes in _Pharm. Journ._, April 11, 1874. 810.


FLORES ARNICÆ.

=Botanical Origin=—See preceding article.

=History=—The flowers probably in the first line attracted the
attention of popular medicine in Germany, as we pointed out, page 390.

=Description=—_Arnica montana_ produces large, handsome, orange-yellow
flowers, solitary at the summit of the stem or branches. The involucral
scales of the capitulum (20 to 24) are of equal length, but are
imbricated, forming a double row. They are very hairy, the shorter
hairs being tipped with viscid glands. The receptacle is chaffy, ¼ of
an inch in diameter, with about 20 ligulate florets, and of tubular
a much larger number. The ligulate florets, an inch in length, are
oblong, toothed at the apex, and traversed by about 10 parallel veins.
The achenes are brown and hairy, crowned by pappus consisting of a
single row of whitish barbed hairs.

The receptacle is usually inhabited by a fly, _Trypeta arnicivora_
Löw[1444]; the Pharmacopœia Germania (1872) therefore ordered the
florets to be deprived of the involucre and receptacle—“flosculi a
peranthodio liberati.” From a chemical point of view the usefulness of
this direction may be doubted.

[1444] Figured in Nees von Esenbeck’s _Plantæ medicinales_, Düsseldorf,
ii. (1833) fol. 39.

Arnica flowers have a weak, not unpleasant odour; they were formerly
used in making the tincture, but as the British Pharmacopœia now
directs that preparation to be made with the root, they have almost
gone out of use in Great Britain.

=Chemical Composition=—The flowers appear to be rather richer in
arnicin than the root, and are said to be equal if not superior to it
in medicinal powers; yet the essential oil they contain is not the
same. It is obtained in but extremely small amount and has a greenish
or blue coloration. Hesse (1864) has proved that the flowers are devoid
of a peculiar volatile alkaloid which had been supposed to be present
in them.


RADIX TARAXACI.

_Dandelion Root_, _Taraxacum Root_; F. _Pissenlit_; G.
_Löwenzahnwurzel_.

=Botanical Origin=—_Taraxacum officinale_ Wiggers _T. Dens-leonis_
Desf., _Leontodon Taraxacum_ L., a plant of the northern hemisphere,
found over the whole of Europe, Central and Northern Asia, and
North America, extending to the Arctic regions. It varies under a
considerable number of forms, several of which have been regarded as
distinct species. In many districts it is a troublesome weed.

=History=—Though the common Dandelion is a plant which must have been
well known to the ancients, no indubitable reference to it can be
traced in the classical authors of Greece and Italy; it is thought
that ἀθάκη of Theophrast and others means it. The word _Taraxacum_ is
however usually regarded as of Greek origin;[1445] we have first met
with as _Tarakhshagun_ in the works of the Arabian physicians, who
speak of it as a sort of _Wild Endive_. It is thus mentioned by Rhazes
in the 10th, and by Avicenna in the 11th century.

The name _Dens Leonis_, an equivalent of which is found in nearly
all the languages of Europe, is stated in the herbal of Johann von
Cube[1446] to have been bestowed on this plant by one Wilhelm, a
surgeon, who held it in great esteem; but of this personage and of the
period during which he lived we have sought information in vain, and we
may remember that Dens Leonis (“Dant y Llew”) is already met with in
the Welsh medicine of the 13th century.[1447]

Dandelion was also much valued as medicine in the time of Gerarde and
Parkinson, and is still extensively employed.

=Collection=—In England, taraxacum root is considered to be in
perfection for extract in the month of November, the juice at that
period affording an ampler and better product than at any other.
Bentley contends that it is more bitter in March, and most of all in
July, and that at the former period at least it should be preferred.

=Description=—The root is perennial, and tapering, simple, or slightly
branched, attaining in a good soil a length of a foot or more, and half
an inch to an inch in diameter. Old roots divide at the crown into
several heads. The root is fleshy and brittle; externally of a pale
brown, internally white, and abounding in an inodorous milky juice of
bitter taste. It shrinks very much in drying, losing in weight about 76
per cent.[1448]

Dried dandelion root is half an inch or less in thickness, dark
brown, shrivelled with wrinkles running lengthwise often in a spiral
direction; when quite dry, it breaks easily with a short corky
fracture, showing a very thick white bark, surrounding a woody column.
The latter is yellowish, very porous, without pith or rays. A rather
broad but indistinct cambium-zone separates the wood from the bark,
which latter exhibits numerous well-defined concentric layers. The root
has a bitterish taste.

=Microscopic Structure=—On the longitudinal section, especially
in a tangential direction, the brownish zones are seen to contain
laticiferous vessels, only about 2 mkm. in diameter. These traverse
their zones in a vertical direction, giving off numerous lateral
branches, which however remain always confined to their zone. Within
each of these zones, the lacticiferous vessels form consequently an
anastomosing net. We may say that the root is thus vertically traversed
by about 10 to 20 concentric rings of lacticiferous vessels.[1449] They
may be made beautifully evident by means of anilin-blue, with which
a thin longitudinal section of the fresh root may be moistened. The
root must be allowed to partially dry, but only till the milky juice
coagulates; the thin slice then energetically absorbs the colouring
matter.[1450]

[1445] Perhaps from τράζυνον or τρόξμνον signifying _Wild Lettuce_;
according to some, from τάραξις, a disease of the eye which the plant
was used to cure, or from the verb τάρασσω, _I disturb_.

[1446] _Herbarius zu teutsch und von aller handt kreuteren_, Augspurg,
1488. cap. clii.

[1447] The _Physicians of Myddvai_, 284 (see Appendix).

[1448] Thus 5496 lb. of the washed root afforded of dry only 1277
lb., or 23·2 per cent.—Information communicated by Messrs. Allen and
Hanburys, London.

[1449] For further particulars about them, see Vogl, _Sitzungsber.
der Wiener Akademie_, vi. (1863) 668 with plate; Hanstein,
_Milchsaftgefässe und verwandte Organe der Rinde_, Berlin, 1864. 72.
73. pl. ix.

[1450] The reader who is not familiar with this process may refer to a
paper by Pocklington in _Pharm. Journ._ April 13, 1872. 822.

The tissue of the dried root is loaded with inulin, which does not
occur in the solid form in the living plant. The woody part of
taraxacum root is made up of large scalariform vessels accompanied by
parenchymatous tissue, the former much prevailing.

=Chemical Composition=—The fresh milky juice of dandelion is bitter
and neutral, but it soon acquires an acid reaction and reddish brown
tint, at the same time coagulating with separation of masses of what
has been called by Kromayer (1861), _Leontodonium_. This chemist, by
treating this substance with hot water, obtained a bitter solution
yielding an active (?) principle to animal charcoal, from which it was
removed by means of boiling spirit of wine. After the evaporation of
the alcohol, Kromayer purified the liquid by addition of basic acetate
of lead, saturation of the filtered solution with sulphuretted hydrogen
and evaporation to dryness. The residue then yielded to ether an acrid
resin, and left a colourless amorphous mass of intensely bitter taste,
named by Kromayer _Taraxacin_. Polex (1839) obtained apparently the
same principle in warty crystals; he simply boiled the milky juice with
water and allowed the concentrated decoction to evaporate.

The portion of the “_Leontodonium_,” not dissolved by water, yields to
alcohol a crystalline substance, Kromayer’s _Taraxacerin_, C₈H₁₆O. It
resembles lactucerin and has in alcoholic solution an acrid taste. How
far the medicinal value of dandelion is dependent on the substances
thus extracted, is not yet known.

Dragendorff (1870) obtained from the root gathered near Dorpat in
October and dried at 100° C., 24 per cent. of _Inulin_ and some sugar.
The root collected in March from the same place yielded only 1·74 per
cent. of inulin, 17 of uncrystallizable sugar and 18·7 of _Levulin_.
The last named substance, discovered by Dragendorff, has the same
composition as inulin, but dissolves in cold water; the solution tastes
sweetish, and is devoid of any rotatory power. Inulin is often to be
seen as a glistening powder when extract of taraxacum is dissolved in
water.

T. and H. Smith of Edinburgh (1849) have shown that the juice of the
root by a short exposure to the air undergoes a sort of fermentation
which results in the abundant formation of _Mannite_, not a trace of
which is obtainable from the perfectly fresh root. Sugar which readily
underwent the vinous fermentation was found by the same chemists in
considerable quantity.

The leaves and stalks of dandelion (but not the roots) were found by
Marmé (1864) to afford the _Inosite_, C₆H₁₂O + 2 OH.

The root collected in the meadows near Bern immediately before
flowering, carefully washed and dried at 100° C., yielded us 5·24 per
cent. of ash, which we found to consist of carbonates, phosphates,
sulphates, and in smaller quantity also of chlorides.

=Uses=—Taraxacum is much employed as a mild laxative and tonic,
especially in hepatic disorders.

=Adulteration=—The roots of _Leontodon hispidus_ L. (Common Hawkbit)
have occasionally been supplied by fraudulent herb-gatherers in place
of dandelion. Both plants have runcinate leaves, but those of hawkbit
are hairy, while those of dandelion are smooth. The (fresh) root of the
former is tough, breaking with difficulty and rarely exuding any milky
juice.[1451]

The dried root of dandelion is exceedingly liable to the attacks of
maggots, and should not be kept beyond one season.


HERBA LACTUCÆ VIROSÆ.

_Prickly Lettuce_; F. _Laitue vireuse_; G. _Giftlattich_.

=Botanical Origin=—_Lactuca virosa_ L.,[1452] a tall herb occurring
on stony ground, banks and roadsides, throughout Western, Central and
Southern Europe. It is abundant in the Spanish Peninsula and in France,
but in Britain is only thinly scattered, reaching its northern limit in
the south-eastern Highlands of Scotland.

=History=—The introduction of this lettuce into modern medicine is due
to Collin (the celebrated physician of Vienna, mentioned in our article
on Rad. Arnicæ, p. 390), who about the year 1771 recommended the
inspissated juice in the treatment of dropsy. In long standing cases,
this extract was given to the extent of half an ounce a day.

The College of Physicians of Edinburgh inserted _Lactuca virosa_ L.
in their pharmacopœia of 1792, while in England its place was taken
by the Garden Lettuce, _L. sativa_ L. The Authors of the _British
Pharmacopœia_ of 1867 have discarded the latter, and directed that
_Extractum Lactucæ_ shall be prepared by inspissating the juice of _L.
virosa_.

=Description=—The plant is biennial, producing in its first year
depressed obovate undivided leaves, and in its second a solitary
upright stem, 3 to 5 feet high, bearing a pinacle of small, pale yellow
flowers, resembling those of the Garden Lettuce. The stem, which is
cylindrical and a little prickly below, has scattered leaves growing
horizontally; they are of a glaucous green, ovate-oblong, often
somewhat lobed, auricled, clasping, with the margin provided with
irregular spinescent teeth, and midrib white and prickly. The whole
plant abounds in a bitter, milky juice of strong, unpleasant, opiate
smell.

=Chemical Composition=—We are not aware of any modern chemical
examination having been made of _Lactuca virosa_. The more important
constituents of the plant are those found in _Lactucarium_, to the
article on which the reader is referred.

=Uses=—The inspissated expressed juice of the fresh plant is reputed
narcotic and diuretic, but is probably nearly inert.

[1451] Giles, _Pharm. Journ._ xi. (1851) 107.

[1452] Bentham unites this plant with _L. Scariola_ L., but in most
works on botany they are maintained as distinct species.


LACTUCARIUM.

_Lactucarium_, _Lettuce Opium_, _Thridace_;[1453] F. and G.
_Lactucarium_.

=Botanical Origin=—The species of _Lactuca_ from which lactucarium is
obtained, are three or four in number, namely—

1. _Lactuca virosa_ L., described in the foregoing article.

2. _L. Scariola_ L., a plant very nearly allied to the preceding
and perhaps a variety of it, but having the foliage less abundant,
more glaucous, leaves more sharply lobed, much more erect and almost
parallel with the stem. It has the same geographical range as _L.
virosa_.

3. _L. altissima_ Bieb., a native of the Caucasus, now cultivated in
Auvergne in France for yielding lactucarium. It is a gigantic herb,
having when cultivated a height of 9 feet and a stem 1½ inches in
diameter. Prof. G. Planchon believes it to be a mere variety of _L.
Scariola_ L.

4. _L. sativa_ L., the common Garden Lettuce.[1454]

=History=—Dr. Coxe of Philadelphia was the first to suggest that
the juice of the lettuce, collected in the same manner as opium is
collected from the poppy, might be usefully employed in medicine. The
result of his experiments on the juice which he thus obtained from
the garden lettuce (_L. sativa_ L.), and called _Lettuce Opium_, was
published in 1799.[1455]

The experiments of Coxe were continued some years later by Duncan,
Young, Anderson, Scudamore and others in Scotland, and by Bidault
de Villiers and numerous observers in France. The production of
lactucarium in Auvergne was commenced[1456] by Aubergier, pharmacien of
Clermont-Ferrand, about 1841.

=Secretion=—All the green parts of the plant are traversed by a
system of vessels, which when wounded, especially during the period
of flowering, instantly exude a white milky juice. The stem, at first
solid and fleshy but subsequently hollow, owes its rigidity to a circle
of about 30 fibro-vascular bundles, each of which includes a cylinder
of cambium. At the boundary between this tissue and the primary
cortical parenchyme, is situated the system of milk-vessels, exhibiting
on transverse section a single or double circle of thin-walled tubes,
the cavities of which contain dark brown masses of coagulated juice.
In longitudinal section, they appear branched and transversely bound
together, as in the milk-vessels of taraxacum. The larger of these
tubes, 35 mkm. in diameter, correspond pretty regularly in position
with the vascular bundles. Each of the latter is also separated from
the pith by a band or arch of cambium, in the circumference of which
isolated smaller milk-vessels occur.

The system of milk-vessels[1457] is therefore double, belonging to
the pith on the one side, and to the bark on the other, the two being
separated by juiceless wood. The milk-vessels of the bark are covered
by only 2 to 6 rows of parenchyme-cells of the middle bark, rapidly
decreasing in size from within outwards, and these are protected by a
not very thick-walled epidermis. Hence it is easy to understand how the
slightest puncture or incision may reach the very richest milk-cells.

[1453] The term Thridace is also applied to _Extract of Lettuce_.

[1454] The authors of the French _Codex_ of 1866 name as the source of
lactucarium that form of the garden lettuce which has been called by
DeCandolle _Lactuca capitata_. Maisch has obtained lactucarium from _L.
elongata_ Mühl. (_Am. Journ. of Pharm._ 1869. 148).

[1455] Inquiry into the comparative effects of the _Opium officinarum_,
extracted from the _Papaver somniferum_ or _White Poppy_ of Linnæus,
and that procured from the _Lactuca sativa_ or _Common cultivated
Lettuce_ of the same author.—_Transact. of the American Philosophical
Society_, iv. (1799) 387.

[1456] _Comptes Rendus_, xv. (1842) 923.

[1457] Beautifully delineated by Hanstein in the work referred to at p.
352, note 2; see also Trécul, _Ann. des Sciences nat. Bot._ v. (1866)
69; Dippel, _Entstehung der Milchsaftgefässe_, Rotterdam, 1865. tab. 1.
fig. 17.

The drops of milky juice, when exposed to the air, quickly harden to
small yellowish-brown masses, whitish within.

=Collection and Description=—Lactucarium has been especially collected
since about the year 1845, in the neighbourhood of the small town of
Zell on the Mosel between Coblenz and Trèves in Rhenish Prussia. The
introduction of this industry is due to Mr. Goeris, apothecary of that
place, to whom we are indebted for the following information, and for
some further particulars, to Mr. Meurer of Zell.

The plant is grown in gardens, where it produces a stem only in its
second year. In May just before it flowers, its stem is cut off at
about a foot below the top, after which a transverse slice is taken
off daily until September. The juice, which is pure white but readily
becomes brown on the surface, is collected from the wounded top by
the finger, and transferred to hemispherical earthen cups, in which
it quickly hardens so that it can be turned out. It is then dried in
the sunshine until it can be cut into four pieces, when the drying is
completed by exposure to the air for some weeks on frames.

At Zell, 300 to 400 kilogrammes (661 to 882 lb.) of lactucarium
are annually produced; the whole district furnishes at best but 20
quintals annually. The price the drug fetches on the spot varies from
4 to 10 thalers per kilogramme (about 6_s._ to 14_s._ per lb.) In the
Eifel district, where lactucarium was formerly collected, none is now
produced.

As found in trade, German lactucarium consists of angular pieces formed
as already described, but rendered more or less shrunken and irregular
by loss of moisture and by fracture. Externally they are of a dull
reddish-brown, internally opaque and wax-like, and when recent, of a
creamy white. By exposure to the air, this white becomes yellow and
then brown. Lactucarium has a strong unpleasant odour, suggestive of
opium, and a very bitter taste.

The lactucarium produced by Aubergier of Clermont-Ferrand is of
excellent quality, but does not appear to differ from that obtained
on the Mosel, except that it is in circular cakes about 1½ inches in
diameter, instead of in angular lumps.

Scotch lactucarium, which was formerly the only sort found in the
market, is still (1872) met with. Mr. Fairgrieve, who produces it in
the neighbourhood of Edinburgh, collects the juice into little tin
vessels, in which it quickly thickens; it is then turned out and dried
with a gentle heat, the drug being broken up as the process of drying
goes on. It is thus obtained in irregular earthy-looking lumps of a
deep brown hue, of which the larger may be about an inch in length. In
smell, it exactly resembles the drug collected on the Continent.[1458]

[1458] We are indebted to Mr. H. C. Baildon for a specimen of Scotch
lactucarium collected about the year 1844, and to Messrs. T. and H.
Smith for a sample of Mr. Fairgrieve’s article.

We have also before us Austrian lactucarium, prepared at Waidhofen on
the Thaya, where about 35 kilogrammes are annually produced. It is in
fine tears of vigorous smell.

We are unacquainted with Russian lactucarium, which has been quoted at
a very high price in some continental lists.

=Chemical Composition=—Lactucarium is a mixture of very different
organic substances, together with 8 to 10 per cent. of inorganic
matter. It is not completely taken up by any solvent, and when heated
merely softens but does not melt. Nearly half the weight of lactucarium
consists of a substance called _Lactucerin_ or _Lactucon_, which in our
opinion is closely allied to if not identical with similar substances
occurring in numerous milky juices. Lactucerin as afforded by the drug
under examination is probably a mixture of several bodies. It may be
obtained by exhausting lactucarium with boiling alcohol sp. gr. 0·830;
it is deposited in crystals, which when duly purified have the form of
slender colourless, microscopic needles. Lactucerin is an inodorous,
tasteless substance, insoluble in water, but dissolving in ether and in
oils both fixed and volatile, not quite so readily either in benzol, or
in bisulphide of carbon. We found it to melt at 232° C. and to agree
with the formula C₁₉H₃₀O; Franchimont (1879) assigns to it the formula
C₁₄H₂₄O, melting point 296°.

Euphorbon (see Euphorbium), echicerin (see Cortex Alstoniæ),
taraxacerin (p. 394), the cynanchol, C₁₅H₂₄O, extracted in 1875 by
Buttleroff from _Cynanchum acutum_ L., are remarkably analogous to
lactucerin.

In the lactucarium of Zell, we further met with a large amount of a
substance which is readily soluble in bisulphide of carbon. It is an
amorphous mass, melting below 100°, separating from alcohol as a syrupy
mass.

Cold alcohol, as well as boiling water, takes out of lactucarium
about 0·3 per cent. of a crystallizable bitter substance, _Lactucin_,
C₁₁H₁₂O₃H₂O, which although it reduces alkaline cupric tartrate, is
not a glucoside. It may be best obtained by means of dialyse. Lactucin
forms white pearly scales, readily soluble in acetic acid, but
insoluble in ether. It loses its bitterness when treated with an alkali.

From the mother-liquors that have yielded lactucin, Ludwig, in
1847, obtained _Lactucic Acid_, as an amorphous light yellow mass,
becoming crystalline after long standing. Lastly lactucarium has
further afforded in small quantity an amorphous substance named
_Lactucopicrin_, C₄₄H₆₄O₂₁, apparently produced from lactucin by
oxidation; it is stated by Kromayer (1862) to be soluble in water or
alcohol, and to be very bitter.

Of the widely diffused constituents of plants, lactucarium contains
caoutchouc (40-50 per cent.), gum, oxalic, citric, malic and succinic
acids, sugar, mannite, and asparagin, together with potassium, calcium
and magnesium salts of nitric and phosphoric acids. We obtained
crystals of nitrate of potassium by concentrating the aqueous decoction
of lactucarium. On distillation with water, a volatile oil having the
odour of lactucarium passes over in very small quantity.

=Uses=—The soporific powers universally ascribed in ancient times
to the lettuce are supposed to exist in a concentrated form in
lactucarium. Yet numerous experiments have failed to show that this
substance possesses more than very slight sedative properties, if
indeed it is not absolutely inert.[1459]




LOBELIACEÆ.


HERBA LOBELIÆ.

_Lobelia_, _Indian Tobacco_; F. _Lobelie enflée_; G. _Lobeliakraut_.

=Botanical Origin=—_Lobelia inflata_ L., an annual herb, 9 to 18
inches high, with an angular upright stem, simple or more frequently
branching near the top, widely diffused throughout the eastern part
of North America from Canada to the Mississippi, growing in neglected
fields, along roadsides, and on the edges of woods, and thriving well
in European gardens.

=History=—_Lobelia inflata_ was described and figured by Linnæus[1460]
from specimens cultivated by him at Upsala about 1741, but he does not
attribute to the plant any medicinal virtues.

The aborigines of North America made use of the herb, which from this
circumstance and its acrid taste, came to be called _Indian Tobacco_.
In Europe it was noticed by Schöpf,[1461] but with little appreciation
of its powers. In America it has long been in the hands of quack
doctors, but its value in asthma was set forth by Cutler in 1813. It
was not employed in England until about 1829, when, with several other
remedies, it was introduced to the medical profession by Reece.[1462]

=Description=—The leaves are 1 to 3 inches long, scattered, sessile,
ovate-lanceolate, rather acute, obscurely toothed, somewhat pubescent.
The edge of the leaf bears small whitish glands, and between them
isolated hairs which are more frequent on the under than on the upper
surface. They are usually in greater abundance on the lower and middle
portions of the stem.

The stem of the growing plant exudes when wounded a small quantity of
acrid milky juice, contained in laticiferous vessels running also into
the leaves. The inconspicuous blossoms are arranged in a many-flowered,
terminal, leafy raceme. The five-cleft, bilabiate corolla is bluish
with a yellow spot on the under lip, its tube being as long as the
somewhat divergent limb of the calyx.

The capsule is ovoid, inflated, ten-ribbed, crowned by five elongated
sepals which are half as long as the ripe fruit. The latter is
two-celled, and contains a large number of ovate-oblong seeds about
¹/₅₀ of an inch in length, having a reticulated, pitted surface.

The herb found in commerce is in the form of rectangular cakes, 1
to 1¾ inches thick, consisting of the yellowish-green chopped herb,
compressed as it would seem while still moist, and afterwards neatly
trimmed. The cakes arrive wrapped in paper, sealed up and bearing the
label of some American druggist or herb-grower.

[1459] Stillé, _Therapeutics and Mat. Med._ i. (1868) 756. Garrod
(_Med. Times and Gazette_, 26 March, 1864), gave lactucarium in drachm
doses, repeated 3 or 4 times a day, without being able to perceive that
it had any effect either as an anodyne or hypnotic.

[1460] _Acta Soc. Reg. Scient. Upsal._ 1746. 23.

[1461] _Mat. Med. Americana_, Erlangæ, 1787. 128.

[1462] _Treatise on the Bladder-podded Lobelia_, Lond. 1829.

Lobelia has a herby smell and, after being chewed, a burning acrid
taste resembling that of tobacco.

=Chemical Composition=—Lobelia has been examined by Procter, Pereira
(1842), Reinsch (1843), Bastick (1851), also by F. F. Mayer.[1463]
The first-named chemist[1464] traced the activity of the plant to
an alkaloid which he termed _Lobelina_, and his observations were
confirmed by the independent experiments of Bastick.[1465] Lewis (1878)
obtained it by mixing the drug with charcoal and exhausting the powder
with water containing a little acetic acid. The liquid is cautiously
evaporated to the consistency of an extract and triturated with
magnesia, from the excess of which the aqueous solution of lobeline is
separated by filtration. It is agitated with amylic alcohol (or ether),
which by spontaneous evaporation affords the alkaloid. The latter is
again dissolved in water and filtered through animal charcoal; from the
dried powder lobeline is to be removed by ether.

Lobeline is an oily, yellowish fluid with a strong alkaline reaction,
especially when in solution. In the pure state it smells slightly of
the plant, but more strongly when mixed with ammonia. Its taste is
pungent and tobacco-like, and when taken in minute doses, it exercises
in a potent manner the poisonous action of the drug. Lobeline is to
some extent volatile, but its decomposition begins when it is heated to
100° C. either pure or in presence of dilute acids or caustic alkalis.
Lobeline dissolves in water, but more readily in alcohol or ether, the
latter of which is capable of removing it from its aqueous solution.
It neutralizes acids, forming with some of them crystallizable salts,
soluble in water or alcohol.

The herb likewise contains traces of essential oil (the _Lobelianin_ of
Pereira?), resin and gum. The seeds afforded Procter about 30 per cent.
of fixed oil, sp. gr. 0·940, which was found to dry very rapidly. The
_Lobeliin_ of Reinsch appears to be an indefinite compound.

In 1871 Enders at our request performed some researches on Lobelia in
order to isolate the acrid substance to which the herb owes its taste.
He exhausted the drug with spirit of wine and distilled the liquid in
presence of charcoal, which then retained the acrid principle. The
charcoal was washed with water, and then treated with boiling alcohol.
This on evaporation yielded a green extract, which was further purified
by means of chloroform. Warty tufts were thus finally obtained, yet
always of a brownish colour. The tufts are readily soluble in ether and
chloroform, but only slightly in water; they possess the acrid taste of
lobelia. This substance, which we may term _Lobelacrin_, is decomposed
if merely boiled with water; by the influence of alkalis or acids it is
resolved into sugar and _Lobelic Acid_. The latter is soluble in ether,
water, and alcohol, and is non-volatile; it yields a soluble salt with
baryum oxide, whereas its plumbic salt is insoluble in water.

[1463] _American Journ. of Pharm._ xxxvii. (1866) 209; also
_Jahresbericht_ of Wiggers and Husemann, 1866. 252.

[1464] _Am. Journ. of Pharm._ iii. (1838) 98; vii. (1841) 1; _Pharm.
Journ._ x. (1851) 456.

[1465] _Pharm. Journ._ x. (1851) 270.

Lewis suggests that lobelacrin is nothing else than _lobeliate of
lobeline_, which he believes to exist ready formed in the plant. From
a decoction of the drug, on addition of sulphate of copper, lobeliate
of copper is precipitated. By decomposing the latter with sulphuretted
hydrogen, concentrating the solution and shaking it with warm ether,
Lewis obtained a yellow solution affording on evaporation a crystalline
mass of lobelic acid.

=Uses=—Lobelia is a powerful nauseating emetic; in large doses an
acro-narcotic poison. It is prescribed in spasmodic asthma.




ERICACEÆ.


FOLIA UVÆ URSI.

_Bearberry Leaves_; F. _Feuilles de Busserole_; G.
_Bärentraubenblätter_.

=Botanical Origin=—_Arctostaphylos Uva-ursi_ Sprengel (_A. officinalis_
Wimmer et Grabowsky, _Arbutus Uva-ursi_ L.), a small, procumbent,
evergreen shrub, distributed over the greater part of the northern
hemisphere. It occurs in North America, Iceland, Northern Europe, and
Russian Asia, and on the chief mountain chains of Central and Southern
Europe. In Britain it is confined to Scotland, the north of England,
and Ireland.

=History=—The bearberry was used in the 13th century by the Welsh
“Physicians of Myddfai,” described by Clusius in 1601, and recommended
for medicinal use in 1763 by Gerhard of Berlin and others.[1466] It had
a place in the London Pharmacopœia for the first time in 1788.

=Description=—The leaves are dark green, ¾ to 1 inch in length by ²/₈
to ⅜ of an inch in breadth, obovate, rounded at the end, gradually
narrowed into a short petiole. They are entire, with the margin a
little reflexed, and in the young state slightly pubescent, otherwise
the whole leaf is smooth, glabrous, and coriaceous; the upper surface
shining, deeply impressed with a network of veins; the under minutely
reticulated with dark veins.[1467] The leaves have a very astringent
taste, and when powdered a tea-like smell.

=Chemical Composition=—Kawalier (1852) has shown that a decoction
of bearberry treated with basic acetate of lead yields a gallate of
that metal, thus proving that gallic acid exists ready-formed in the
leaves. When the filtrate, freed from lead by sulphuretted hydrogen, is
properly concentrated, it deposits acicular crystals of _Arbutin_, a
bitter neutral substance, easily soluble in hot water, less so in cold,
dissolving in alcohol, but sparingly in ether.

By contact for some days with emuslin, or by boiling with dilute
sulphuric acid, arbutin is resolved, according to Hlasiwetz and
Habermann (1875), as follows:—

    C₂₅H₃₄O₁₄ + 2 OH₂ = C₆H₁₂O₆ · C₆H₄(OH)₂  ·  C₆H₄(OH·OCH₃)
     Arbutin.          Glucose.  Hydrokinone.  Methyl-hydrokinone.

Yet possibly arbutin is a mixture of the glucoside compounds of both
hydrokinone and methyl-hydrokinone.

[1466] Murray, _Apparatus Medicaminum_, ii. (1794) 64-81.

[1467] Microscopic structure of the leaves, see Pocklington, _Pharm.
Journ._ v. (1874) 301.

By heating arbutin with peroxide of manganese and dilute sulphuric
acid, on the other hand, _Kinone_, C₆H₄O₂, and formic acid are
produced. If a concentrated decoction of the leaves is allowed to stand
for some months, a decomposition of the arbutin takes place, and a
certain quantity of hydrokinone can be isolated by shaking the liquid
with ether.

Arbutin is apparently widely distributed among the plants belonging
to the order Ericaceæ. Maisch in 1874 showed it to occur in
_Arctostaphylos glauca_ Swindley, _Gaultheria procumbens_ L.
(Wintergreen) and several other allied American plants. Kennedy (1875)
isolated arbutin from _Kalmia latifolia_ L. (Spoonwood), where it
occurs in smaller quantity than in bearberry leaves.

Kinic acid (see p. 363) is probably absent in all these plants
containing arbutin.

Uloth (1859) had already noticed pyrocatechin (p. 244) and hydrokinone
among the products of the distillation of an aqueous extract of
bearberry leaves. Arbutin itself also yields hydrokinone by means of
dry distillation. Hydrokinone forms colourless crystals, melting at
169° C.

In the mother-liquor from which the arbutin has crystallized,
there remains a small quantity of the very bitter substance called
_Ericolin_, occurring in greater abundance in Calluna, Ledum,
Rhododendron, and other _Ericaceæ_. _Ericolin_ is an amorphous
yellowish mass, softening at 100° C. and resolved, when heated with
dilute sulphuric acid, into sugar and _Ericinol_, a colourless,
quickly resinifying oil of a peculiar, not disagreeable odour; its
composition[1468] agrees with the formula C₁₀H₁₆O. The same, or
C₂₀H₃₂O₂, is to be assigned to _Ursone_, which H. Trommsdorff, in
1854, obtained from bearberry leaves by exhausting them with ether (in
which however it is but slightly soluble). Ursone is a colourless and
tasteless crystallizable substance. It melts at 200° C., and sublimes
apparently unchanged. Tonner (1866) met with it in the leaves of an
Australian _Epacris_, a plant of the same order as the bearberry.

[1468] Gmelin, _Chemistry_, xvi. (1864). 28.

Lastly, tannic acid is present in the leaves under notice; their
aqueous infusion is nearly colourless, but assumes a violet hue on
addition of ferrous sulphate. After a short time a reddish precipitate
is produced, which quickly turns blue. By using ferric chloride, a
bluish black precipitate immediately separates.

=Adulteration=—The leaves of _Vaccinium Vitis-idæa_ L., called _Red
Whortleberry_ or _Cowberry_, have been confounded with those of
bearberry, which in form they much resemble. But they are easily
distinguished by being somewhat crenate towards the apex, dotted and
reticulate on the under surface and more revolate at the margin.

=Uses=—An astringent tonic used chiefly in affections of the bladder.




EBENACEÆ.


FRUCTUS DIOSPYRI.

_Indian Persimmon._

=Botanical Origin=—_Diospyros Embryopteris_ Pers. (_Embryopteris
glutinifera_ Roxb.), a middle-sized or large evergreen tree, native
of the western coast of India, Ceylon, Bengal, Burma, Siam, and also
Java.[1469]

=History=—The tree, which is mentioned in the earliest epic poems of
the Sanskrit literature under the name of _tinduka_,[1470] was also
known about the year 1680 to Rheede, and was figured in his _Hortus
Malabaricus_.[1471] The circumstance that the unripe fruit abounds in
an astringent viscid juice which is used by the natives of India for
daubing the bottoms of boats, was communicated by Sir William Jones to
Roxburgh in 1791. The introduction of the fruit into medicine, which is
due to O’Shaughnessy,[1472] has been followed by its admission to the
_Pharmacopœia of India_, 1868.

=Description=—The fruit is usually solitary, subsessile or pedunculate,
globular or ovoid, 1½ to 2 inches long, and as much as 1½ inch in
diameter, surrounded at the base by a large and deeply 4-lobed calyx.
It is of a yellowish colour, covered with a rusty tomentum; internally
it is pulpy, 6-to 10-celled, with thin flat solitary seeds. The
fruit is used only in the unripe and fresh state; the pulp is then
excessively astringent. At maturity, in the month of April near Bombay,
the fruit becomes eatable, but is very little appreciated.

=Chemical Composition=—No analysis has been made of this fruit, but
there can be no doubt that in common with that of other species of
_Diospyros_, it is, when immature, rich in tannic acid. Charropin
(1873),[1473] who has examined the fruit of the American _D.
virginiana_ L., found it to contain a tannic acid which he considered
identical with that of nutgalls, besides an abundance of pectin,
glucose, and a yellow colouring matter insoluble in water but
dissolving freely in ether.

=Uses=—The inspissated juice has been recommended as an astringent in
diarrhœa and chronic dysentery.

[1469] Fig. in Bentley and Trimen, _Med. Plants_, part 18 (1877).

[1470] As we learn from Dr. Rice.—Prof. Dymock (1876) gives _Timbooree_
as the Bombay name.

[1471] Tom. iii. tab. 41.

[1472] _Bengal Dispensatory_, Calcutta, 1842. 428.

[1473] _Etude sur le Plaqueminier_ (_Diospyros_), thèse, Paris, 1873.
28-30.




STYRACEÆ.


RESINA BENZOË.

_Benzoïnum_; _Benzoin_, _Gum Benjamin_; F. _Benjoin_; G.
_Benzoëharz_.[1474]

=Botanical Origin=—_Styrax Benzoin_ Dryander, a tree of moderate
height, with stem as thick as a man’s body and beautiful crown of
foliage, indigenous to Sumatra and Java, in the first of which islands
benzoin is produced.

[1474] _Benzoin_ in Malay and Javanese is termed _Kamâñan_, _Kamiñan_,
and _Kamayan_, abbreviated to _mâñan_ and _miñan_ (Crawfurd); it is
called in Siamese _kom-yan_ or _kan-yan_; in Chinese _ngán-si-hiáng_.

The name _Benzoin_ is also applied to the beautiful prisms C₁₄H₁₂O₂
obtained by treating Bitter Almond Oil with an alcoholic solution of
potash.

The tree yielding the superior benzoin of Siam, though commonly
referred to this species, has never been examined botanically, and is
actually unknown. The French expedition for the exploration of the
Mekong and Cochin China (1866-68), reported the drug to be produced
in the cassia-yielding forests on the eastern bank of the river in
question in about N. lat. 19°. Whether any benzoin is obtained from _S.
Finlaysoniana_ Wall, as conjectured by Royle, we know not.

=History=—There is no evidence that the Greeks and Romans,[1475] or
even the earlier Arabian physicians, had any acquaintance with benzoin;
nor is the drug to be recognized among the commodities which were
conveyed to China by the Arab and Persian traders between the 10th and
13th centuries, though the camphor of Sumatra is expressly named.

The first mention of benzoin known to us (disregarding the word
kalanusari, which in the St. Petersburg Dictionary is given as the old
Sanskrit name of benzoin) occurs in the travels of Ibn Batuta,[1476]
who having visited Sumatra during his journey through the East, A.D.
1325-49, notes that the island produces _Java Frankincense_ and
camphor. The word _Java_ was at that period a designation of Sumatra,
or was even used by the Arabs to signify the islands and productions
of the Archipelago generally.[1477] Hence came the Arabic name _Lubán
Jáwí_, i.e. _Java Frankincense_, corrupted into _Banjawi_, _Benjui_,
_Benzui_, _Benzoë_ and _Benzoïn_, and into the still more vulgar
English _Benjamin_.

We have no further information about the drug until the latter half of
the following century, when we find a record that in 1461 the sultan
of Egypt, Melech Elmaydi, sent to Pasquale Malipiero, doge of Venice,
a present of 30 _rotoli_ of _Benzoi_, 20 _rotoli_ of Aloes Wood, two
pairs of Carpets, a small flask of balsam (of Mecca), 15 little boxes
of Theriaka, 42 loaves of Sugar, 5 boxes of Sugar Candy, a horn of
Civet, and 20 pieces of Porcelain.[1478] Agostino Barberigo, another
doge of Venice, was presented in a similar manner in 1490 by the sultan
of Egypt with 35 _rotoli_ of Aloes Wood, the same quantity of _Benzui_
and 100 loaves of Sugar.[1479]

Among the precious spices sent from Egypt in 1476 to Caterina
Cornaro, queen of Cyprus, were 10 lb. of Aloes Wood and 15 lb. of
_Benzui_.[1480] These notices indicate the high value set upon the drug
when first brought to Europe.

The occurrence of benzoin in Siam is noticed in the journal of the
voyage of Vasco da Gama,[1481] where, in enumerating the kingdoms of
India, it is stated that Xarnaux (Siam[1482]) yields much benzoin worth
3 _cruzados_, and aloes worth 25 _cruzados_ per _farazola_. According
to the same record, the price of benzoin (_beijoim_) in Alexandria was
1 _cruzado_ per _arratel_, half the value of aloes wood.

[1475] Crawfurd suggests that the _Malabathrum_ of the ancients is
possibly _benzoin_.—_Dict. of Indian Islands_, 1856. 50.

[1476] _Voyages d’Ibn Batoutah_, traduit par Defrémery et Sanguinetti,
Paris, 1853-59. iv. 228. 240.

[1477] Yule, _Book of Ser Marco Polo_, ii. (1871) 228.

[1478] Muratori, _Rerum Italicarum Scriptores_, xxii. (1733) 1170.—100
_rotoli_ = 175 lb. avoirdupois.

[1479] L. de Mas Latrie, _Hist. de l’île de Chypre_, etc. iii. (1861)
483.

[1480] _Ibid._ iii. 406.

[1481] _Roteiro da Viagem de Vasco da Gama em 1497_, par Herculano e o
Barão Castello de Paiva, segunda edição, Lisboa, 1861. 109.

The Roteiro is also found in Flückiger, _Documente zur Geschichte der
Pharmacie_, Halle, 1876. 13.

[1482] Yule, _op. cit._ ii. 222.

The Portuguese traveller Barbosa[1483] visited in 1511 Calicut on the
Malabar Coast, and found _Benzui_ to be one of the more valuable items
of export, one _farazola_ (22 lb. 6 oz.) costing 65 to 70 _fanoes_;
camphor fetched nearly the same price, and mace only 25 to 30 _fanoes_.
From other sources we gather that benzoin was an article of Venetian
trade in the beginning of the 16th century.

Garcia de Orta, writing at Goa (1563), was the first to give a lucid
and intelligent account of benzoin, detailing the method of collection,
and distinguishing the drug of Siam and Martaban from that produced in
Java and Sumatra.

It began then to be regularly imported into Europe,[1484] being
frequently called _Asa dulcis_. The chemists of that time submitted
it, like many other substances, to dry distillation. Benzoic acid
occasionally separating from the oily products (“_oleum Benzoës_”) was
noticed already by Nostredame,[1485] Rosello,[1486] Liebaut,[1487]
Blaise de Vigenère,[1488] and others. It was a common pharmaceutical
preparation, under the name of _Flores Benzoës_, since the 17th
century.[1489]

In the early part of the 17th century, there was direct commercial
intercourse between England and both Siam and Sumatra, an English
factory existing at Ayuthia (Siam) until 1623; and benzoin was
doubtless one of the commodities imported. The import duties levied
upon it in England in 1635 amounted to 10_s._ per lb.[1490]

=Production=—Benzoin is collected in Northern and Eastern Sumatra,
especially in the Batta country, lying southward of the state of
Achin.[1491] The tree grows in plenty also in the highlands of
Palembang in the south and its resin is collected. It is chiefly on
the coast regions that considerable plantations are found. Teysmann
saw the cultivation in the tracts of the river Batang Leko, the trees
being planted about 15 feet apart. The benzoin from the interior is
mostly from wild trees, which occur at the foot of the mountains at an
elevation of 300 to 1000 feet.

The trees, which are of quick growth, are raised from seeds grown on
the [edges of?] rice-fields; they require no particular attention
beyond being kept clear of other plants, until about 6 or 7 years old,
when they have trunks 6 to 8 inches in diameter, and are capable of
yielding the resin. Incisions are then made in their stems, from which
there exudes a thick, whitish, resinous juice, which soon hardens by
exposure to the air, and is carefully scraped off with a knife.

[1483] Flückiger, _l.c._, page 14.

[1484] Cardanus, _Les livres de la subtilité_, Paris, 1556 (first
edition, 1550), page 160 _b._ states: “belzoi est de vil prix pour
l’abondance.”

[1485] _Excellent et moult utile opuscule à touts necessaire qui
desirent avoir cognoissance de plusieurs exquises receptes_, 1556.

[1486] Alexii Pedemontani (or Hieron. Rosello), _De secretis libri
vi._, Basil, 1560, page 107.

[1487] _Quatre livres de secrets de medecine et de la philosophie
chimique_, Paris, 1579, page 146.

[1488] _Traicté du feu et du sel_, Paris, 1622, page 99.—Vigenère
speaks distinctly of “filamens ou aiguilles,” i.e. crystals.—He died in
1596.

[1489] Flückiger, _Pharm. Journ._ vi. (1876) 1022.

[1490] _The Rates of Marchandizes_, London, 1635.

[1491] Miquel, _Prodromus Floræ Sumatranæ_, 1860. 72; Marsden, _Hist.
of Sumatra_, London, 1783. 123.—The latter author resided at Bencoolen,
as an official of the English Government.

The statement of Crawfurd, _l.c._, that benzoin is collected in
Borneo “_on the northern coast in the territory of Brunai_” is to us
inexplicable. Mr. St. John, British Consul in Borneo, in an official
report on the trade of Brunai, dated from that place 29 January 1858,
enumerates the various productions of the district, but does not name
benzoin.

The trees continue to yield at the rate of about three pounds per
annum for 10 or 12 years, after which period they are cut down. The
resin which exudes during the first three years is said to be fuller
of white tears, and therefore of finer quality, than that which issues
subsequently, and is termed by the Malays _Head Benzoin_. That which
flows during the next 7 or 8 years, is browner in colour and less
valuable, and is known as _Belly Benzoin_; while a third sort, called
_Foot_, is obtained by splitting the tree and scraping the wood; this
last is mixed with much bark and refuse.[1492]

Benzoin is brought for sale to the ports of Sumatra in large cakes
called _Tampangs_, wrapped in matting. These have to be broken, and
softened either by the heat of the sun or by that of boiling water, and
then packed into square cases which the resin is made to fill.

The only account of the collection of _Siam Benzoin_ is that given by
Sir R. H. Schomburgk, for some years British Consul at Bangkok.[1493]
He represents that the bark is gashed all over, and that the resin
which exudes, collects and hardens between it and the wood, the former
of which is then stripped off. This account is confirmed by the aspect
of some of the Siam benzoin of commerce as well as by that of pieces
of bark in our possession; but it is also evident that _all_ the Siam
drug is not thus obtained. Schomburgk adds, that the resin is much
injured and broken during its conveyance in small baskets on bullocks’
backs to the navigable parts of the Menam, whence it is brought down to
Bangkok.[1494]

Whether benzoin owes its original fluidity to a volatile oil holding
the resin in solution, and its solidification to the volatilization
of this oil, or whether the resin itself hardens by oxidation,—what
occasions the remarkable diversity of aspect between the opaque and
milk-like, and the completely transparent resin, are questions to be
investigated by some future observer.

=Description=—Benzoin (always termed in English commerce _Gum
Benjamin_) is distinguished as of two kinds, _Siam_ and _Sumatra_.
Each sort occurs in various degrees of purity, and under considerable
differences of appearance.

1. _Siam Benzoin_—The most esteemed sort is that which consists
entirely of flattened tears or drops, an inch or two long, of an
opaque, milk-like, white resin, loosely agglutinated into a mass.
More frequently the mass is quite compact, consisting of a certain
proportion of white tears of the size of an almond downwards, imbedded
in a deep, rich amber-brown, translucent resin. Occasionally the
translucent resin preponderates, and the white tears are almost
wanting. In some packages, the tears of white resin are very small,
and the whole mass has the aspect of a reddish-brown granite. There is
always a certain admixture of bits of wood, bark, and other accidental
impurities.

[1492] The terms _Head_, _Belly_ and _Foot_, equivalent to our
words _superior_, _medium_ and _inferior_, are used in the East to
distinguish the qualities of many other commodities, as Borneo Camphor,
Esculent Birds’-nests, Cardamoms, Galbanum, &c.

[1493] This account must have been derived from others, for Sir R. H.
Schomburgk never visited the region producing benzoin.

[1494] _Pharm. Journ._ iii. (1862) 126.

The white tears when broken, display a stratified structure with layers
of greater or less translucency. By keeping, the white milky resin
becomes brown and transparent on the surface.

Siam benzoin is very brittle, the opaque tears showing a slightly waxy,
the transparent a glassy fracture. It easily softens in the mouth and
may be kneaded with the teeth like mastich. It has a delicate balsamic,
vanilla-like, fragrance, but very little taste. When heated it evolves
a more powerful fragrance, together with the irritating fumes of
benzoic acid; its fusing point is 75° C. The presence of benzoic acid
may be shown by the microscopical examination of splinters of the resin
under oil of turpentine.

Siam benzoin is imported in cubic blocks, which takes their form from
the wooden cases in which they are packed while the resin is still soft.

2. _Sumatra Benzoin_—Prior to the renewal of direct commercial
intercourse with Siam in 1853, this was the sort of benzoin most
commonly found in commerce.

It is imported in cubic blocks exactly like the preceding, from which
it differs in its generally greyer tint. The mass however, when the
drug is of good quality, contains numerous opaque tears, set in a
translucent, greyish-brown resin, mixed with bits of wood and bark.
When less good, the white tears are wanting, and the proportion of
impurities is greater. We have even seen samples consisting almost
wholly of bark. In odour, Sumatra benzoin is both weaker and less
agreeable than the Siam drug, and generally falls short of it in
purity[1495] and handsome appearance, and hence commands a much lower
price. The greyish-brown portion melts at 95°, the tears at 85° C.

A variety of Sumatra benzoin is distinguished by the London
drug-brokers as _Penang Benjamin_ or _Storax-smelling Benjamin_. We
have seen it of very fine quality, full of white tears (some of them
two inches long), the intervening resin being greyish.[1496] The odour
is very agreeable, and perceptibly different from that of Siam benzoin,
or the usual Sumatra sort. Whether this drug is produced in Sumatra
and by _Styrax Benzoin_ we know not; but it is worthy of note that _S.
subdenticulata_ Miq., occurring in Western Sumatra, has the same native
name (_Kajoe Kĕminjan_) as _S. Benzoin_, and that Miquel remarks of
it—“_An etiam benzoiferum?_”[1497]

=Chemical Composition=—Benzoin consists mainly of amorphous resins
perfectly soluble in alcohol and in potash, having slightly acid
properties, and differing in their behaviour to solvents. If two parts
of the drug are boiled with one part of caustic lime and 20 parts of
water, benzoin acid is removed. From the residue the excess of lime is
dissolved by hydrochloric acid, and the remaining resins washed and
dried. About one-third of them will be found readily soluble in ether,
the prevailing portion dissolves in alcohol, and a small amount remains
undissolved.

[1495] In the _Public Ledger_, May 2, 1874, the prices are quoted
thus:—Siam Gum Benjamin, 1st and 2nd qualities, £10 to £28 per cwt.;
Sumatra, 1st and 2nd, £7 10_s._ to £12.

[1496] There were 8 cases of this drug offered at Public Sale, 13 April
1871.

[1497] _Prod. Floræ Sumatranæ_, 1860. 474.

By distilling the resin of benzoin with ten times its weight of zinc
dust, Ciamician (1878) chiefly obtained toluol, C₆H₅(CH₃).

Subjected to dry distillation, benzoin affords as chief product
_Benzoic Acid_, C₇H₆O₂, together with empyreumatic products, among
which Berthelot has proved the presence (in Siam benzoin) of _Styrol_
(p. 274). The latter has been obtained in 1874 by Theegarten from
Sumatra benzoë by distilling it with water. When the resin is fused
with potash, it is partly decomposed and then, according to Hlasiwetz
and Barth (1866), yields among other products, protocatechuic acid
(more than 5 per cent.), C₆H₃(OH)₂COOH, para-oxybenzoic acid,
C₆H₄(OH)COOH, and pyrocatechin, C₆H₄(OH)₂.

_Benzoic acid_ exists ready-formed in the drug to the extent of 14 to
18 per cent.[1498] Although the acid dissolves in 12 parts of boiling
water, the resin in which it is imbedded precludes its complete
extraction by this means. It is however easily accomplished by the
aid of an alkali, most advantageously by milk of lime, which does not
combine with the amorphous resins.

Benzoin is not manifestly acted on by bisulphide of carbon, but if kept
in contact with it for a month or two, very large colourless crystals
of benzoic acid make their appearance. Brought into a warm room, the
crystals quickly dissolve, but are easily reproduced by exposure to
cold.

Most pharmacopœias require not the inodorous acid obtained by a wet
process, but that afforded by sublimation, which contains a small
amount of fragrant empyreumatic products. The resin, when repeatedly
subjected to sublimation, affords as much as 14 per cent. of benzoic
acid. It has long been known that the opaque white tears of benzoin are
less rich in benzoic acid than the transparent brown resin in which
they lie. From the latter, S. W. Brown (1833) extracted 13 per cent.
of impure acid, but from the former scarcely 8½ per cent. We are by no
means sure that such difference is constant.

Bitter almond oil, which by oxidation yields benzoic acid, is wanting
in benzoin. Very little volatile oil is in fact to be got; half a pound
of the best Penang benzoin yielded us by distillation with water only a
few drops of an extremely fragrant oil (_styrol?_).

Ferric chloride imparts to an alcoholic solution of benzoin a dark
brownish green, which is not acquired under the same circumstances by
the aqueous decoction of the powdered resin. Benzoin dissolves in cold
oil of vitriol, forming a solution of splendid carmine hue, from which
water separates crystals of benzoic acid.

Kolbe and Lautemann in 1860 discovered in Siam and Penang benzoin
together with benzoic acid, an acid of different constitution, which in
1861 they recognized as _Cinnamic Acid_, C₉H₉O₂. Aschoff (1861) found
in a sample of Sumatra benzoin, cinnamic acid only, of which he got
11 per cent.; and in amygdaloid Siam and Penang benzoin only benzoic
acid. In some samples of the latter, one of us (F.) has likewise met
with cinnamic acid. On triturating this sort with peroxide of lead and
boiling the mixture with water, the odour of bitter almond oil, due to
the oxidation of cinnamic acid, is evolved.

[1498] Löwe (1870) and Rump (1878) attempted to prove that the acid is
partly present in the form of a compound, but they have not shown with
which substance it is combined in the drug.

The simultaneous occurrence of benzoic and cinnamic acids, or the
absence of one or other of them in benzoin, is due to circumstances at
present unexplained. Rump is of the opinion that the last named acid
exclusively is present in the Penang (or Sumatra) benzoin and that no
variety of the drug contains both those acids.

Rump (1878) treated Siam benzoic with caustic lime (see p. 407),
precipitated the benzoic acid with hydrochloric acid, and agitated the
liquid with ether. The latter on evaporating afforded a mixture of
benzoic acid and _Vanillin_ (see article Vanilla).

=Commerce=—The statistics of Singapore,[1499] the great emporium of the
commerce of the Indian Archipelago, show the imports of Gum Benjamin
in 1871 as 7442 cwt., of which quantity 6185 cwt. had been shipped
from Sumatra and 405 cwt. from Siam. In 1877 only 1871 peculs (2227
cwts.) were exported from Singapore. Penang, which is also a mart
for this drug was stated in 1871 to have received from Sumatra for
trans-shipment, 4959 cwt. of Gum Benjamin.

Padang in Sumatra exported in 1870, 4303 peculs (5122 cwt.); and in
1871, 4064 peculs (4838 cwt.) of benzoin.[1500]

The imports of Gum Benjamin into Bombay in the year 1871-72 were no
less than 5975 cwt., and the exports 1043 cwt.[1501]

=Uses=—Benzoin appears to be nearly devoid of medicinal properties, and
is but little employed. It is chiefly imported for use as incense in
the service of the Greek Church.




OLEACEÆ.


MANNA.

_Manna_; F. _Manne_; G. _Manna_.

=Botanical Origin=—_Fraxinus Ornus_ L. (_Ornus europæa_ Pers.), the
Manna-ash, is a small tree found in Italy, whence it extends northwards
as far as the Canton of Tessin in Switzerland and the Southern Tyrol.
It also occurs in Hungary (Buda) and the eastern coasts of the
Adriatic, in Greece, Turkey (Constantinople), in Asia Minor about
Smyrna and at Adalia on the south coast. It grows in the islands of
Sicily, Sardinia and Corsica, and is found in Spain at Moxente in
Valencia.[1502] As an ornamental tree it has been introduced into
Central Europe, where it is often seen of greater dimensions, sometimes
acquiring a height of about 30 feet. It blossoms in early summer,
producing numerous feathery panicles of dull white flowers which give
it a pleasing appearance. The foliage exhibits great variation in shape
of leaflets, even where the tree is uncultivated; and the fruits also
are very diverse in form.

In some districts of Sicily, a little manna is obtained from the Common
Ash, _F. excelsior_ L.

[1499] _Blue Book_ for the Colony of the Straits Settlements,
Singapore, 1872.

[1500] _Consular Reports_, August 1873. 953.

[1501] _Statement of the Trade and Navigation of the Presidency of
Bombay for 1871-72_, pt. ii. 26. 79.

[1502] _Fraxinus Bungeana_ DC., a tree of Northern China, appears to be
hardly distinct from _F. Ornus_.

=History=—The name _Manna_, though originally applied to the aliment
miraculously provided for the sustenance of the ancient Israelites
during their journey to the Holy Land, has been used to designate other
substances of distinct nature and origin. Of these, the best known and
most important is the saccharine exudation of _Fraxinus Ornus_ L.,
which constitutes the _Manna_ of European medicine.

It appears evident[1503] that previous to the 15th century, the manna
in Europe was imported from the East and was not that of the ash.
Raffaele Maffei, called also Volaterranus, a writer who flourished
in the second half of the 15th century, states that manna began to
be gathered in Calabria in his time, but that it was inferior to the
oriental.[1504] At this period the manna collected was that which
exuded spontaneously from the leaves of the tree, and was termed _Manna
di foglia_ or _Manna di fronda_: that which flowed from the stem bore
the name of _Manna di corpo_ and was less esteemed. All such manna was
very dear.

About the middle of the 16th century, the plan of making incisions in
the trunk and branches was resorted to, and although it was strenuously
opposed even by legislative enactment, the more copious supplies which
it enabled the collectors to obtain led it to being generally adopted.
The Ricettario Fiorentino of the year 1573[1505] states that the manna
“fatta con arte,” _i.e._ obtained by incisions, came from Cosenza in
Calabria and differed not little from Syrian “manna mastichina.”[1506]

_Manna di foglia_ became in fact utterly unknown, so that Cirillo
of Naples, writing in 1770, expresses doubt whether it ever had any
existence.[1507]

With regard to the history of manna-production in Sicily, there is
this curious fact, that near Cefalù there exists an eminence in the
Madonia range, called _Gebelman_ or _Gibelmanna_, which in Arabic
signifies _manna-mountain_. This name is not of modern origin, but is
found in a diploma of the year 1082, concerning the foundation of the
bishopric of Messina; and it has been held to indicate that manna was
there collected during the Saracenic occupation of Sicily, A.D. 827 to
1070. We have not been successful in finding any evidence whether this
supposition is well founded. On the other hand, it is remarkable that
no writer, so far as we know, mentions manna as a production of Sicily,
before Paolo Boccone of Palermo, who, after naming many localities
for the drug in continental Italy, states that it is also obtained in
Sicily.[1508]

Manna was also produced until recently in the Tuscan Maremma, but
neither from that locality, nor from the States of the Church, where it
was collected in the time of Boccone, is any supply now brought into
commerce, though the name of Tolfa, a town near Civita Vecchia, is
still used to designate an inferior sort of the drug.

The collection of manna in Calabria, which was imported up to the end
of last century, has now almost entirely ceased.[1509]

[1503] Hanbury, _Historical Notes on Manna_, _Pharm. Journ._ xi. (1870)
326; or _Science Papers_, 355.

[1504] _Commentarii Urbani_, Paris, 1515. lib. 38. f. 413.

[1505] P. 46; we have not seen the edition of 1498.

[1506] Mastichina alludes probably to the granular form of that
manna—perhaps it was that of Alhagi, which we shall mention further on,
p. 414.

[1507] _Phil. Trans._ lx. (1771) 233.

[1508] _Museo di Fisica_, Venet. 1697. Obs. xiv.-xv.

[1509] Hanbury in _Giornale Botanico Italiano_, Ottobre 1872. 267;
_Pharm. Journ._ Nov. 30. 1872. 421; _Science Papers_, 365.

=Production=—The manna of commerce is collected at the present day
exclusively in Sicily. The principal localities producing the drug
are the districts around Capaci, Carini, Cinisi, and Favarota, small
towns 20 to 25 miles west of Palermo near the shores of the bay of
Castellamare; also the townships of Geraci, Castelbuono, and other
places in the district of Cefalù, 50 to 70 miles eastward of Palermo.

The manna-ash, in the districts whence the best manna is obtained, does
not at the present day form natural woods, but is cultivated in regular
plantations called _frassinetti_. The trees, which attain a height of
from 10 to 20 feet, are planted in rows and stand about 7 feet apart,
the soil between being at times loosened, kept free from weeds, and
enriched by manure. After a tree is 8 years old and when its stem is at
least 3 inches in thickness, the gathering of manna may begin; and may
continue for 10 or 12 years, when the stem is usually cut down, and a
young one brought up from the same root takes its place. The same stump
thus has often two or three stems rising from it.

To obtain manna, transverse cuts from 1½ to 2 inches long and 1 inch
apart, are made in the bark, just reaching to the wood. One cut is made
daily, beginning at the bottom of the tree, the second directly above
the first, and so on while dry weather lasts. In the following year,
cuts are made in the untouched part of the stem, and in the same way
in succeeding seasons. When after some years the tree has been cut all
round and is exhausted, it is felled. Pieces of sticks or straws are
inserted in the incisions, and become encrusted with the very superior
manna, called _Manna a cannolo_, which however is unknown in commerce
as a special sort. The fine manna ordinarily seen appears to have
hardened on the stem of the tree. The manna which flows from the lower
incisions, and is often collected on tiles or on a cup-shaped piece of
the stem of the prickly pear (_Opuntia_), is less crystalline, and more
gummy and glutinous, and is regarded of inferior quality.

The best time for notching the stems is in July and August, when the
trees have ceased to push forth more leaves. Dry and warm weather is
essential for a good harvest. The manna after removal from the tree,
is laid upon shelves in order that it may dry and harden before it is
packed. The masses left adhering to the stem after the finer pieces
have been gathered, are scraped off and form part of the _Small Manna_
of commerce.[1510]

=Secretion=—We have examined microscopically the bark of stems of
_Fraxinus Ornus_ that had been incised for manna at Capaci. It exhibits
no peculiarity explaining the formation of manna, or any evidence that
the saccharine exudation is due to an alteration of the cell-walls
as in the case of tragacanth. The bark is poor in tannic matter; it
contains starch, and imparts to water a splendid fluorescence due to
the presence of _Fraxin_.

[1510] Our account of the production of manna has been derived from
the observations of Stettner, who visited Sicily in the summer of 1847
(_Archiv der Pharm._ iii. 194; also Wiggers’ _Jahresbericht_, 1848.
35; _Hooker’s Journ. of Bot._ i. 1849. 124), from those of Cleghorn
(_Trans. of the Bot. Soc. of Edinburgh_, x. 1868-69. 132), and from
personal investigations made by one of us in the neighbourhood of
Palermo in May 1872. See Hanbury, _Science Papers_, 367.

=Description=—Various terms have been used by pharmacological writers
to designate the different qualities of manna, but in English commerce
they are not now employed; and the better kinds of the drug are called
simply _Flake Manna_, while the smaller pieces, usually loosely
agglutinated and sold separately, are termed _Small Manna_ or _Tolfa
Manna_.

Owing to the gradual exudation of the juice and the deposition of one
layer over another, manna has a stalactitic aspect. The finest pieces
are mostly in the form of three-edged sticks, sometimes as much as 6
to 8 inches long and an inch or more wide, grooved on the inner side,
which is generally soiled by contact with the bark; of a porous,
crystalline, friable structure and of a pale brownish yellow tint,
becoming nearly pure white in those parts which have been most distant
from the bark of the tree. The pieces which are of deeper colour, and
of an unctuous or gummy appearance, are less esteemed. Good manna is
crisp and brittle, and melts in the mouth with an agreeable, honey-like
sweetness, not entirely devoid of traces of bitterness and acridity.
Its odour may be compared to that of honey or moist sugar.

Manna of the best quality dissolves at ordinary temperatures in about
six parts of water, forming a clear, neutral liquid. It contains
besides mannite, a small proportion of sugar and gum.

The manna which exudes from the older stems and from the lower parts
of even young trees, contains more or less considerable quantities
of gum and fermentable sugar, as well as extraneous impurities. The
less favourable weather of the later summer and autumn promotes an
alteration in the composition of the juice, and impairs its property of
concreting into a crystalline mass.

=Chemical Composition=—The predominant constituent of manna, at least
of the better sorts, is _Manna-sugar_ or _Mannite_, C₆H₈(OH)₆ which
likewise occurs, though in much smaller quantity, in many other plants
besides _Fraxinus_. Artificially, it is produced by treating glucose,
C₆H₁₂O₆, with sodium amalgam, and indirectly in the fermentation of
glucose or of cane-sugar. It is isomeric with dulcite or melampyrin;
crystallizes in shining prisms or tables, belonging to the rhombic
system; melts at 166° C., and in very small quantity may by careful
heating be sublimed and decomposed. It dissolves in 6·5 parts of water
at 16° C., less freely in aqueous alcohol, very sparingly in absolute
alcohol, and not in ether. The solution has an extremely weak rotatory
power, and is not altered by boiling with dilute acids or alkalis, or
with alkaline cupric tartrate.

Berthelot has shown that mannite is susceptible of fermentation, though
not so easily as sugars belonging to the group of carbo-hydrates. The
quantity of mannite in the best manna varies from 70 to 80 per cent.

When a solution of manna is mixed with alkaline cupric tartrate,
rapid reduction to cuprous hydrate takes place even in the cold. This
effect is due to the presence of a sugar which, according to Backhaus
(1860), consists of ordinary dextro-glucose. It may amount to as
much as 16 per cent., and is found in the best flake manna, but most
abundantly in the unctuous varieties. Buignet[1511] has pointed out
that the rotatory power of this sugar being inconsiderable, it probably
consists of a mixture of _Cane-sugar_ and _Levulose_. He found however
that an aqueous solution of manna deviates powerfully to the right, a
fact which he considers due to the presence of a large proportion of
_Dextrin_. The best kinds of manna, according to Buignet, contain about
20 per cent. of dextrin; the inferior much more.

[1511] _Journ. de Pharm._ vii. (1867) 401; viii. (1868) 5.

In our experiments we have not succeeded in isolating either dextrin or
cane-sugar. There is present, even in the finest manna, a small amount
of a dextrogyre mucilage, which is precipitated by neutral acetate of
lead, and yields mucic acid when boiled with concentrated nitric acid.

Ether extracts from an aqueous solution of manna a very small quantity
of red-brown resin, having an offensive odour and sub-acrid taste;
together with traces of an acid which reduces silver salts and appears
to be easily resinified. The quantity of water in the inferior kinds
of manna often amounts to 10 or 15 per cent. The finest manna affords
about 3·6 per cent. of ash.

The greenish colour of certain pieces of manna was formerly attributed
to the presence of copper, till Gmelin, on account of the fluorescence
of the solution, ascribed it to _Æsculin_. It is in reality produced by
a body much resembling æsculin, namely _Fraxin_, C₁₆H₁₈O₁₀, occurring
in the bark of the manna-ash and of the common ash, and together
with æsculin, in that of the horse-chestnut. Fraxin crystallizes in
colourless prisms, easily soluble in hot water and in alcohol, and
having a faintly astringent and bitter taste. By dilute acids, it is
resolved into _Fraxetin_, C₁₀H₈O₃, and _Glucose_, C₆H₁₂O₆. The presence
of fraxin in manna, especially in the inferior sorts, is made apparent
by the faint fluorescence of the alcoholic manna solution. The smallest
fragment of the bark of the ash or the manna-ash immersed in water
displays the same fluorescence.

=Commerce=—The exports of manna from Sicily[1512] (chiefly from
Palermo) have been as follows:—

       1869              1870              1871
     2546 cwt.,        1564 cwt.,        3038 cwt.,
    val. £15,972.     val. £10,220.     val. £19,528.

About half the quantity is sent to France. Italian commercial
statistics[1513] represent the export of manna in 1870 thus:—_in
canelli_ 58,691 kilo. (1155 cwt.), _in sorte_ 186,664 kilo. (3676
cwt.). The United Kingdom imported in the year 1870, 230 cwt. of manna,
valued at £4447.[1514]

[1512] _Report by Consul Dennis on the Commerce and Navigation of
Sicily in 1869, 1870 and 1871._

[1513] Direzione generale delle Gabelle—_Movimento commerciale del
regno d’Italia nel 1870_, Milano, 1871.

[1514] _Annual Statement of the Trade and Navigation of the U.K. for
1870_, p. 102.

In 1877 the exports of “canelli” from Messina were 4273 kilogrammes,
and of the drug “in sorte” 52,874 kilogr.; total value, 127,145 lire.

=Adulteration=—It can hardly be said that manna is subject to
adulteration, though attempts to introduce a spurious manna made of
glucose have been recorded. But considerable skill and ingenuity have
been expended in converting the inferior sorts of manna into what has
the aspect of fine natural Flake Manna, the manufacturers admitting
however the factitiousness of their product. The artificial Flake Manna
has the closest superficial resemblance to very fine pieces of the
natural drug, but differs in its more uniform colour, and in being
uncontaminated with the slight impurities, from which natural manna is
never wholly free. It differs also in that when broken, no crystals of
mannite are to be seen in the interstices of the pieces, and it wants
the peculiar odour and slightly bitter flavour of natural manna. If one
part of it is boiled with four of alcohol (0·838), a viscid honey-like
residue will be obtained, whereas natural manna leaves undissolved a
hard substance. Histed[1515] found it to afford about 40 per cent. of
mannite, while fine manna similarly treated yielded 70 per cent.

=Uses=—A gentle laxative, much less frequently employed in this country
than formerly, but still largely consumed in South America. Mannite,
which possesses similar properties, is often prescribed in Italy.

Other sorts of Manna.

Various plants besides _Fraxinus_ afford, under certain conditions,
saccharine exudations, some of which constituted the _Oriental Manna_
used in Europe in early times. So far as is known, they differ from
officinal manna in containing no mannite.

_Alhagi Manna_; _Turanjabín_ (Arabic); is afforded by _Alhagi
Camelorum_ Fisch. (Hedysarum Alhagi Pallas, non L.), a small spiny
plant of the order _Leguminosæ_ found in Persia, Afghanistan and
Beluchistan. It had already been noticed by Isztachri.[1516] Excellent
specimens of the manna, kindly obtained for us in the north-west of
India by Dr. E. Burton Brown and Mr. T. W. H. Tolbort, show it as a
substance in little roundish, hard, dry tears, varying from the size
of a mustard seed to that of a hemp seed, of a light brown colour,
agreeable saccharine taste, and senna-like smell. The leaflets, spines
and pods of the plant, mixed with the grains of this manna, are
characteristic and easily recognizable.

Villiers (1877) showed this manna to contain cane-sugar, a dextrogyrate
glucose, and _melezitose_ (see further on: Briançon manna, page 416).
Ludwig[1517] had also found some dextrin and mucilage.

Alhagi Manna is collected near Kandahar and Herat, where it is found
on the plants at the time of flowering. It is imported into India
from Kabul and Kandahar to the extent of about 25 _maunds_ (2000 lb.)
annually; its value is reckoned at 30 rupees per _secr_, = 30_s._ per
lb.[1518]

[1515] _On artificial Flake Manna_, in _Pharm. Journ._ xi. (1870) 629.

[1516] Tchihatcheff, _l’Asie mineure_, ii. (1856) 355.

[1517] _Archiv der Pharmacie_, 193 (1870) 32-52.

[1518] Stewart, _Punjab Plants_, Lahore (1869) p. 57; Davies, _Report
on the trade and resources of the countries on the N. W. boundary of
British India_, Lahore, 1862.

_Gaz-anjabin_ (Arabic); _Tamarisk Manna_ (in part)—In the months
of June and July, the shrubs of tamarisk (_Tamarix gallica_ var.
_mannifera_ Ehrenb.) growing in the valleys of the peninsula of Sinai,
especially in the Wady es Sheikh, exude from their slender branches, in
consequence of the puncture of an insect (_Coccus manniparus_ Ehrenb.)
little honey-like drops, which in the coolness of early morning are
found in a solid state. This substance is _Tamarisk Manna_: it is
collected by the Arabs, and by them sold to the monks of St. Katharine,
who dispose of it to the pilgrims visiting the convent. Tamarisk Manna
is also produced (but is perhaps no longer collected?) in Persia,
where it is called _Gaz-angabín_;[1519] and probably likewise in the
Punjab,[1520] from which regions it may have been brought to Europe in
ancient times.

A specimen of tamarisk manna brought from Sinai, examined in 1861 by
Berthelot, had the appearance of a thick yellowish syrup, contaminated
with vegetable remains. It was found to consist of cane-sugar, inverted
sugar (lævulose and glucose), dextrin and water, the last constituting
one-fifth of the whole.[1521]

Although the name _Gaz-angabín_ signifies _tamarisk-honey_, it is
used according to Haussknecht[1522] at the present time in Persia, to
designate certain round cakes, common in all the bazaars, of which the
chief constituent is a manna collected in the mountain districts of
Chahar-Mahal and Faraidan, and especially about the town of Khonsar,
south-west of Ispahan, from _Astragalus florulentus_ Boiss. et
Haussk. and _A. adscendens_ Boiss. et Haussk. The best sorts of this
manna, which are termed _Gaz Alefi_ or _Gaz Khonsari_, are obtained
in August by shaking it from the branches, the little drops finally
sticking together and forming a dirty, greyish-white, tough mass. The
commoner sort got by scraping the stem, is still more impure. The
specimen of it brought by Haussknecht yielded to Ludwig[1523] dextrin,
uncrystallizable sugar and organic acids.

_Shir-khist_—Ancient writers on materia medica as Garcia d’Orta (1563)
mention a sort of manna known by this name. The substance is still
found in the bazaars of North-western India, being imported in small
quantity from Afghanistan and Turkistan.[1524] Haussknecht in his paper
on Oriental Manna already quoted, states that it is the exudation
of _Cotoneaster nummularia_ Fisch. et Mey. (_Rosaceæ_), also of
_Atraphaxis spinosa_ L. (_Polygonaceæ_), and that it is brought chiefly
from Herat. We have to thank Dr. E. Burton Brown of Lahore, and Mr.
Tolbort for specimens of this manna, which, from fragments it contains,
is without doubt derived from a _Cotoneaster_. It is in irregular
roundish tears, from about ¼ up to ¾ of an inch in greatest length,
of an opaque dull white, slightly clammy, and easily kneaded in the
fingers. It has a manna-like smell, a pure sweet taste and crystalline
fracture. With water, it forms a syrupy solution with an abundant
residue of starch granules.

Shír-khist was found by Ludwig to consist of an exudation analogous
to tragacanth, but containing at the same time two kinds of gum, an
amorphous levogyre sugar, besides starch and cellulose.

_Oak Manna_—The occurrence of a saccharine substance on the oak is
noticed by both Ovid and Virgil, and it is also mentioned by the
Arabian physicians, as Ibn Baytar[1525] and Elluchasem Elimithar.[1526]
The last named, who died A.D. 1052, states that the exudation appears
upon the oaks in the region of Diarbekir. At the present day, it is
the object of some industry among the wandering tribes of Kurdistan,
who, according to Haussknecht, collect it from _Quercus Vallonea_
Kotschy and _Q. persica_ Jaub. et Spach. These trees are visited in the
month of August by immense numbers of a small white _Coccus_, from the
puncture of which a saccharine fluid exudes, and solidifies in little
grains. The people go out before sunrise, and shake the grains of manna
from the branches on to linen cloths, spread out beneath the trees. The
exudation is also collected by dipping the small branches on which it
is formed, into vessels of hot water, and evaporating the saccharine
solution to a syrupy consistence, which in this state is used for
sweetening food, or is mixed with flour to form a sort of cake.

[1519] Angelus, _Pharm. Persica_ (see appendix) p. 359.

[1520] Stewart, _op. cit._ p. 92.

[1521] _Comptes Rendus_, liii. (1861) 583; _Pharm. Journ._ iii. (1862)
274.

[1522] _Archiv d. Pharmacie_, 192 (1870) 246.

[1523] _Loc. cit._

[1524] Davies in the work quoted at page 414, note 4.

[1525] Ed. Sontheimer, i. (1840) 375.

[1526] _Tacuini Sanitatis_, Argentorati (1531) 24.

A fine specimen of the Oak Manna of Diarbekir was sent to the London
International Exhibition of 1862. It constituted a moist soft mass of
agglutinated tears, much resembling an inferior sort of ash-manna, and
had an agreeable saccharine taste.

A less pure form of this manna occurs as a compact, greyish, saccharine
mass, sometimes hard enough to be broken with a hammer. It consists
of sugary matter, mixed with abundance of small fragments of green
leaves, and has a herby smell and pleasant sweet taste. A sample of it
brought from Diarbekir, examined by one of us, yielded 90 per cent.
of dextrogyre sugar, which could not be obtained in a crystalline
state, though it exists in such condition in the crude drug. Starch and
dextrine were entirely wanting.[1527]

A specimen furnished to Ludwig[1528] by Haussknecht afforded much
mucilage, a small amount of starch, about 48 per cent. of dextrogyre
grape sugar, with traces of tannic acid and chlorophyll.

_Briançon Manna_—This is a white saccharine substance which, in the
height of summer and in the early part of the day, is found adhering in
some abundance to the leaves of the larch (_Pinus Larix_ L.), growing
on the mountains about Briançon in Dauphiny. It was formerly collected
for use in medicine, but only to a very limited extent, for it was
rare in Paris in the time of Geoffroy (1709-1731), and at the present
day has quite disappeared from trade, though still gathered by the
peasants. A specimen collected for one of us near Briançon in 1854,
consists of small, detached, opaque, white tears, many of them oblong
and channelled, and encrusting the needle-like leaf of the larch; they
have a sweet taste and slight odour.[1529] Under the microscope they
exhibit indistinct crystals.

Briançon manna has been examined in 1858 by Berthelot, who detected
in it a peculiar sugar termed _Melezitose_, answering to the formula
C₁₂H₂₂O₁₁ + OH₂.

Several other saccharine exudations have been observed by travellers
and naturalists; we shall simply enumerate the more remarkable,
referring the reader for further information to the original notices.

_Pirus glabra_ Boiss. affords in Luristan a substance which, according
to Haussknecht, is collected by the inhabitants, and is extremely like
Oak Manna. It is stated by the same traveller that _Salix fragilis_
L., and _Scrophularia frigida_ Boiss., likewise yield in Persia
saccharine exudations. A kind of manna was anciently collected from the
cedar, _Pinus Cedrus_ L.[1530] Manna is yielded in Spain by _Cistus
ladaniferus_ L.[1531] _Australian Manna_, which is in small rounded,
opaque, white, dry masses, is found on the leaves of _Eucalyptus
viminalis_ Labill. It contains a kind of sugar called _Melitose_,[1532]
has a sweet thistle, is devoid of medicinal properties and is not
collected for use.[1533]

[1527] Further particulars, see Flückiger, _Ueber die Eichenmanna von
Kurdistan_, in _Archiv der Pharmacie_, 200 (1872) 159.

[1528] _Loc. cit._ p. 35.

[1529] Hanbury, _Science Papers_, p. 438.

[1530] Geoffroy, _Mat. Med._ ii. (1741) 584.

[1531] Dillon, _Travels through Spain_ (1780) p. 127.

[1532] Gmelin, _Chemistry_, xv. 296.

[1533] _Pharm. Journ._ iv. (1863) 108.

The substance named _Tigala_ (corrupted into _Trehala_), from which a
peculiar sugar has been obtained,[1534] is the coccoon of a beetle, and
not properly a saccharine exudation.[1535]

The _Lerp Manna_ of Australia is also of animal origin.[1536] It
consists of water 14, white thread-like portion 33, sugar 53 parts.
The threads possess some of the characteristic properties of starch,
from which they differ entirely by their form and unalterability even
in boiling water. Yet in sealed tubes, they dissolve in 30 parts of
water at 135° C. The sugar is dextrogyre; it impregnates the threads
as a soft brown amorphous mass. In the purified state it does not
crystallize, even after a long time. By means of dilute sulphuric acid,
the threads are converted into crystalline grape sugar.


OLEUM OLIVÆ.

_Olive Oil_; _Salad Oil_; F. _Huile d’Olives_; G. _Olivenöl_; _Baumöl_;
_Provencer Oel_.

=Botanical Origin=—_Olea europæa_ L., an evergreen tree,[1537]
seldom exceeding 40 feet in height, yet attaining extreme old age,
abundantly cultivated in the countries bordering the Mediterranean,
up to an elevation of about 2000 feet above the sea-level.[1538]
_Olea ferruginea_ Royle (_O. cuspidata_ Wallich), a tree abundant in
Afghanistan, Beluchistan and Western Sind, has been supposed to be
a wild form of _O. europæa_, but is regarded by Brandis[1539] as a
distinct species. It is not known to have been ever cultivated, yet its
fruit, which is of a small size and but sparingly produced, is capable
of affording a good oil.

_History_—In ancient Egypt the olive was known by the term _bāk_; it
can be traced as far as the 17th century before our era.[1540]

According to the elaborate investigations of Ritter[1541] and of
A. De Candolle,[1542] the olive tree is a native of Palestine, and
perhaps of Asia Minor and Greece. Its original area also extends over
north-eastern Africa; Schweinfurth[1543] regards it as undoubtedly
wild on the mountains of Elbe and Soturba in lat. 22 N. on the
western shores of the Red Sea, a locality which he visited in 1868.
The olive tree has also been met with as far eastward as the country
of the Gallas, where it is much appreciated as affording excellent
timber.[1544] It is also stated by Theophrastus, that in his time the
tree was plentiful in the Cyrenaica, the modern Barca, in northern
Africa.

[1534] _Comptes Rendus_, xlvi. (1858) 1276; Gmelin, _Chemistry_, xv.
299.

[1535] Belon, _Singularitez_ (1554) l. 2. cap. 91; Guibourt, _Comptes
Rendus_ (1858) 1213; Hanbury, _Journ. Linn. Soc._, Zoology, iii. (1859)
178; also _Science Papers_, 158.

[1536] Dobson, _Proceedings of Royal Society of Van Diemen’s Land_, i.
(1851) 234; _Pharm. Journ._ iv. (1863) 108; Flückiger, _Wittstein’s
Vierteljahresschrift_, xvii. (1868) 161; _Archiv der Pharmacie_, 196
(1871) 7; abstracted in the _Yearbook of Pharmacy_, 1871. 188.

[1537] Readers desiring full information about the olive tree, its oil,
its history, etc., should refer to the extremely exhaustive work of
Coutance, _l’Olivier_, Paris, 1877, 456 pages, 120 figures.

[1538] Grisebach states the elevation above the sea of
olive-cultivation thus:—Portugal (Algarve) 1400 feet; Sierra Nevada
3000; do., southern slope 4200; Nice 2400; Etna 2200; Macedonia 1200;
Cilicia 2000.—_Die Vegetation der Erde nach ihrer klimatologischen
Anordnung_, i. (1872) 262. 283. 342.

[1539] _Forest Flora of North-western and Central India_, 1874, 307.

[1540] Brugsch-Bey, _Reise nach der grossen Oase Kargeh_, Leipzig,
1878. 80. etc.—See also _Journ. of Botany_, 1879. 52.

[1541] _Erdkunde von Asien_, vii. (part 2. 1844) 516-537.

[1542] _Géographique Botanique_ (1855) 912.

[1543] _Bot. Zeitung_, 1868. 860.

[1544] Arnoux, _Revue des Deux Mondes_, Janvier 1879. 381.

The olive would appear to have been introduced at a very remote period
into north-western Africa and Spain. Willkomm (1876) is of the opinion
that it was originally a native of the whole Mediterranean region.

At the present day it is largely cultivated in Algeria, Spain,
Portugal, Southern France, Italy, the Greek Peninsula and Asia Minor.
In the Crimea the tree grows well, but does not afford good fruit. It
was carried to Lima in Peru about 1560 and still flourishes there, and
in great plenty in the coast valleys further south as far as Santiago
in Chili.[1545]

Olive oil is mentioned in the Bible so frequently that it must have
been an important object with the ancient Hebrews. It held an equally
prominent place among the Greeks and Romans,[1546] whose writers on
agriculture and natural history treat of it in the most circumstantial
manner. Olive fruits preserved in brine were used by the Romans as an
article of food,[1547] and were an object of commerce with Northern
Europe as early as the 8th century.[1548]

=Production=—In common with many important cultivated plants, the
olive occurs under several varieties differing more or less from
the wild form, the finer of which are propagated by grafting. It is
also increased by the suckers which old trees throw up from their
naked roots, and which are easily made to develope into separate
plants.[1549] The fruit, an oval drupe, half an inch to an inch or more
in length, and of a deep purple, is remarkable for the large amount of
fat oil contained in its pulpy portion (sarcocarp). The latter is most
rich in oil when ripe, containing then nearly 70 per cent., besides 25
per cent. of water. The unripe fruit, as well as other parts of the
plant, abounds in mannite, which disappears in proportion as the oil
increases. The ripe olive contains no mannite, it having probably been
transformed into fatty oil.[1550]

[1545] Perez-Rosales, _Essai sur le Chili_, Hambourg, 1857. 133.

[1546] Hehn, _Kulturpflanzen und Hausthiere in ihrem Uebergange
aus Asien nach Griechenland und Italien_, Berlin, 1877. 88-142,—an
interesting account of the importance of the olive in ancient times.

[1547] Specimens may be seen among the antiquities found at Pompei.

[1548] Diploma of Chilperic, A.D. 716.—Pardessus, _Diplomata_,
_Chartæ_, etc., Paris, ii. (1849) 309.

[1549] Winter, in _Pharm. Journ._ Sept. 7, 1872.

[1550] De Luca in _Journ. de Pharm._ xlv. (1864) 65.—Some further
researches by Harz on the formation of olive oil may be found in the
_Jahresbericht_ of Wiggers and Husemann (1870) 392.

The process for extracting olive oil varies slightly in different
countries, but consists essentially in subjecting the crushed pulp of
the ripe fruit to moderate pressure. The olives, which are gathered
from the trees, or collected from the ground, in November, or during
the whole winter and early spring, are crushed under a millstone to
a pulpy mass. This is then put into coarse bags, which, piled upon
one another, are subjected to moderate pressure in a screw press.
The oil thus obtained is conducted into tubs or cisterns containing
water, from the surface of which it is skimmed with ladles. This is
called _Virgin Oil_. After it has ceased to flow, the contents of the
bags are shovelled out, mixed with boiling water, and submitted to
stronger pressure than before, by which a second quality of oil is got.
If the fruit is left for a considerable time in heaps it undergoes
decomposition, yielding by pressure a very inferior quality of oil
called in French _Huile fermentée_. The worst oil of all, obtained from
the residues, has the name of _Huile tournante_ or _Huile d’enfer_.

It is said that in some districts the millstones are so mounted as to
crush the pulp without breaking the olive-stones, and that thus the
oil of the pulp is obtained unmixed with that of the kernels.[1551]
We have made many inquiries in Italy and France as to this method of
oil-making, but cannot find that it is anywhere followed.

The fixed oil of the kernels of ripe olives has been extracted and
examined by one of us (F.). Though the kernels have a bitterish taste,
the oil they yield is quite bland; by exposure to the vapour of
hyponitric acid, it concretes like that of the pulp. If the whole of it
were extracted in making olive oil, it would only be about as 1 part of
oil of the _kernel_, to 40 parts of oil of the _pulp_.

=Description=—Olive Oil is a pale yellow or greenish yellow, somewhat
viscid liquid, of a faint agreeable smell and of a bland oleaginous
taste, leaving in the throat a slight sense of acridity.[1552] Its
specific gravity on an average is 0·916 at 17° C. In cold weather,
olive oil loses its transparency by the separation of a crystalline
fatty body. The deposition takes place at a few degrees above the
freezing point of water, and in some oils even at 10° C. (50° F.) If
the oil is allowed to congeal perfectly, and is then submitted to
strong pressure, about one-third of its weight of solid fat may be
separated. After repeated crystallizations, this fat melts at 20 to 28°
C. The fluid part or _Olein_, continues fluid at -4° to -10° C. Olive
oil belongs to the class of the less alterable, non-drying oils.

The foregoing description does not apply to the inferior sorts of oil,
which congeal more easily, are more or less deep-coloured, have a
disagreeable odour and taste, and quickly turn rancid. These inferior
oils have their special applications in the arts.

=Chemical Composition-=-The chief constituent of olive oil is _Olein_
or more correctly _Triolein_, C₃H₅(O·C₁₈H₃₃O)₃, identical so far as at
present ascertained with the fluid part of all oils of the non-drying
class. The proportion of olein in olive oil, as well as in other oils,
is liable to variation, the result partly of natural circumstances and
partly of the processes of manufacture. The best oils are rich in olein.

[1551] _The Grocer_, April 25, 1868, supplement; Pereira, _Elem. of
Mat. Med._ ii. (1850) 1505.

[1552] This according to our experience is the case even with oil as
it runs from the pulp and therefore in the freshest condition; but the
acrid after-taste is more perceptible in oil which has been long kept.

As to the solid part of olive oil, Chevreul believed it to be
constituted of _Margarin_, which he first examined in 1820. But
Heintz (1852 and later) showed margarin to be a mixture of palmitin
with other compounds of glycerin and fatty acids. Collett in 1854
isolated _Palmitic Acid_, C₁₆H₃₂O₂, from olive oil; and Heintz and Krug
(1857) further proved that _Tripalmitin_ is the chief of the solid
constituents of olive oil. They also met with an acid melting at 71°·4
C., which they regarded as _Arachic Acid_ (p. 187). As to stearic acid,
Heintz and Krug did not fully succeed in evidencing its presence in
olive oil.

Lastly, Benecke discovered in olive oil a small quantity of
_Cholesterin_, C₂₆H₄₄O. It may be removed by means of glacial acetic
acid or alcohol, which dissolve but very little of the oil.

=Commerce=—Various sorts of olive oil are distinguished in the English
market, as Florence, Gallipoli, Gioja, Spanish (Malaga and Seville),
Sicily, Myteline, Corfu and Mogador.

Olive oil was imported into the United Kingdom in the year 1872 to
the value of £1,193,064. Nearly half the quantity was shipped from
Italy, one-fifth from Spain, and the remainder from other Mediterranean
countries.

The average annual production in Italy is estimated at about 3 millions
of hectolitres (66 million gallons), but the quantity exported does not
reach half that amount.

The statistics of the French Government indicate the annual production
of olive oil in France to be not more than 250,000 hectolitres,
equivalent in value to 30 millions of francs (£1,200,000).[1553]

=Uses=—The uses of olive oil in medicine and its immense consumption in
the warmer parts of Europe as an article of food, are too well known to
require more than a passing allusion.

=Adulteration=—Olive Oil is the subject of various fraudulent
admixtures with less costly oils, the means of detecting which has
engaged much attention. Of the various methods by which chemists have
endeavoured to ascertain the purity of olive oil, the following are the
more noteworthy:—

=a.= Drying oils (such as the oils of poppy and walnut) may be
distinguished by their not being converted into solid crystallizable
elaidin by hyponitric acid or concentrated solution of nitrate of
protoxide of mercury. Olive oil which contains any considerable
proportion of one of these oils, no longer solidifies if exposed for a
moment to one of the above-mentioned reagents. This test however is not
of sufficient delicacy for small amounts of drying oils.

=b.= Olive oil being one of the lighter oils, the specific gravity may
to some degree indicate admixture with a heavier oil. To make use of
this fact, Gobley and other chemists have invented an instrument called
an _elaiometer_, for taking the specific gravity of oils.

=c.= Observation of the Cohesion-figure.—This test, proposed by
Tomlinson in 1864,[1554] depends on the forces of cohesion, adhesion,
and diffusion. Thus, if a drop of any oil hanging from the end of a
glass rod is gently deposited upon the surface of chemically clean
water, contained in a clean glass, a contest takes place between the
forces in question the moment the drop flattens down by its gravity
upon the surface of the water. The adhesion of the liquid surface tends
to spread out the drop into a film, the cohesive force of the particles
of the drop strives to prevent that extension, and the resultant of
these forces is a figure which Mr. Tomlinson believes to be definite
for every independent liquid. The figure thus produced is named the
_cohesion-figure_.

[1553] Exposition de 1867 à Paris, _Rapports du Jury International_,
xi. 108.—In the work of Coutance, quoted p. 417, note 7, nearly 400,000
hectolitres are calculated for the year 1866.

[1554] _Pharm. Journ._ v. (1864) 387. 495, with figures.

So far as our experience goes, the processes hitherto recommended for
testing olive oil (and there are several that we have not mentioned)
are only available in cases where the adulteration is considerable, and
are quite insufficient for discovering a small admixture of other oils.
How little they are appreciated, may be inferred from the fact that the
Chamber of Commerce of Nice[1555] offered a reward of 15,000 francs
(£600) for a simple and easy process for making evident an admixture
with olive oil of 5 per cent. at least of any seed-oil.




APOCYNEÆ.


=CORTEX ALSTONIÆ.=

_Cortex Alstoniæ scholaris_; _Dita Bark_;[1556] _Alstonia Bark_.

=Botanical Origin=—_Alstonia[1557] scholaris_ R. Brown (_Echites
scholaris_ L.), a handsome forest tree, 50 to 90 feet in height, common
throughout the Indian Peninsula from the sub-Himalayan region to Ceylon
and Burma; found also in the Philippines, Java, Timor and Eastern
Australia, likewise in Tropical Africa. It has oblong obovate leaves,
in whorls of 5 to 7, and slender pendulous pods a foot or more in
length.

=History=—Saptachhada and saptaparna (literally seven-leaf), occurring
in early Sanskrit epic poetry and also in Susruta, are ancient names
of Alstonia (Dr. Rice). Rheede[1558] in 1678 and Rumphius[1559] in
1741 described and figured the tree, and mentioned the use made of its
bark by the native practitioners. Rumphius also explained the trivial
name _scholaris_ as referring to slabs of the close-grained wood which
are used as school-slates, the letters being traced upon them in sand.
The tonic properties of the bark were favourably spoken of by Graham
in his _Catalogue of Bombay Plants_ (1839), and further recommended
by Dr. Alexander Gibson in 1853[1560]. The drug has a place in the
_Pharmacopœia of India_, 1868.

=Description=—The drug, as presented to one of us by the late Dr.
Gibson and by Mr. Broughton of Ootacamund, consists of irregular
fragments of bark, ⅛ to ½ an inch thick, of a spongy texture, easily
breaking with a short, coarse fracture. The external surface is very
uneven and rough, dark grey or brownish, sometimes with blackish spots;
the interior substance and inner surface (liber) is of a bright buff.
A transverse section shows the liber to be finely marked by numerous
small medullary rays. The bark is almost inodorous; its taste is purely
bitter and neither aromatic nor acrid.

[1555] _Annales de Chimie et de Physique_, March, 1869. 309.

[1556] From _Dita_, the name of the tree in the island of Luzon.

[1557] So named in honour of Charles Alston, Professor of Botany and
Materia Medica (1740-1760) in the University of Edinburgh.—The plant is
figured in Bentley and Trimen, _Med. Pl._ part 25 (1877).

[1558] _Hortus Malabaricus_, i. tab. 45.

[1559] _Herb. Amboin._ ii. tab. 82.

[1560] _Pharm. Journ._ xii. (1853) 422.

=Microscopic Structure=—The cortical tissue is covered with a thin
suberous coat; the middle layer of the bark is built up of a thin
walled parenchyme, through which enormous, hard, thick-walled cells
are scattered in great numbers and are visible to the naked eye, as
they form large irregular groups of a bright yellow colour. Towards the
inner part these stone-cells disappear, the tissue being traversed by
undulated medullary rays, loaded with very small starch grains; many of
the other parenchymatous cells of the liber contain crystals of calcium
oxalate. The longitudinal section of the liber exhibits large but not
very numerous laticiferous vessels, containing a brownish mass, the
concrete milk juice in which all parts of the tree abound.

=Chemical Composition=—The first attempts to isolate the active
principles of this bark were made by two apothecaries, Scharlée at
Batavia[1561] (1862) and Gruppe at Manila[1562] (1872).

In 1875 Jobst and Hesse exhausted the powdered bark with petroleum
ether, and then extracted, by boiling alcohol, the salt of an alkaloid,
which they called _Ditamine_. After the evaporation of the alcohol, it
is precipitated by carbonate of sodium and dissolved by ether, from
which it is removed by shaking it with acetic acid. Ditamine as again
isolated from the acetate forms an amorphous and somewhat crystalline,
bitterish powder of decidedly alkaline character; the barks yields
about 0·02 per cent. of it.

From the substances extracted by means of petroleum ether, as above
stated, Jobst and Hesse further isolated (1) _Echicaoutchin_, C₂₅H₄₀O₂,
an amorphous yellowish mass; (2) _Echicerin_, C₃₀H₄₈O₂, forming
acicular crystals, melting at 157° C.; (3) _Echitin_, C₃₂H₅₂O₂,
crystallized scales, melting at 170°; (4) _Echiteïn_, C₄₂H₇₀O₂, which
forms rhombic prisms, melting at 195°; (5) _Echiretin_, C₃₅H₅₆O₂, an
amorphous substance melting at 52° C.

Echicaoutchin may be written thus: (C₅H₈)₅O₂, echicerin (C₅H₈)₆O₂,
echiretin (C₅H₈)₇O₂; these formulæ at once point out how nearly the
three last named substances are allied. They are probably constituents
of the milky juice of the tree.

Lastly, Jobst and Hesse pointed out the existence of another alkaloid
in Dita bark.

Harnack (1877) on the other hand is of the opinion that it contains
only one alkaloid, which he terms _Ditaïne_. He used the alcoholic
extract of the bark which he treated with ether to which he added a
little ammonia. By this process ditamine of Jobst and Hesse would
have been removed, but Harnack suggests that only a little ditaïne is
dissolved by ether. He then mixed the extract with potash and exhausted
it with alcohol, which afforded crystals of ditaïne, answering to the
formula C₂₂H₃₀N₂O₄; its physiological action is nearly the same as
that of curare. Ditaïne is but sparingly soluble in ether or petroleum
ether, but dissolves readily in water, alcohol, or chloroform; it has a
decidedly alkaline reaction. It would appear that it is a glucoside.

[1561] Geneesk, _Tijdschr. Nederl. Indië_, x. (1863) 209; also _Archiv
der Pharmacie_, 212 (1878) 439.

[1562] _Jahresbericht_ of Wiggers and Husemann, 1873. 51.

Dita bark is stated[1563] to yield 5 per cent. of “ditaïne”; but this
probably refers not to the pure alkaloid.

=Uses=—The bark has been recommended as a tonic and antiperiodic, being
extravagantly praised as a substitute for quinine.




ASCLEPIADEÆ.


=RADIX HEMIDESMI.=

_Hemidesmus Root_, _Nunnari Root_, _Indian Sarsaparilla_.

=Botanical Origin=—_Hemidesmus indicus_ R. Brown (_Periploca indica_
Willd., _Asclepias Pseudo-sarsa_ Roxb.), a twining shrub, growing
throughout the Indian Peninsula and in Ceylon. The leaves are very
diverse, being narrow and lanceolate in the lower part of the plant,
and broadly ovate in the upper branches.[1564]

=History=—In the ancient Sanskrit literature the plant occurs
frequently under the name _Sārivā_, and its root under the name of
_Nannārī_ or _Ananta-mūl_ (_i.e._ endless root) has long been employed
in medicine in the southern parts of India.[1565] Ashburner in 1831
was the first to call the attention of the profession in Europe to
its medicinal value.[1566] In 1864 it was admitted to a place in the
_British Pharmacopœia_, but its efficiency is by no means generally
acknowledged.

=Description=[1567]—The root is in pieces of 6 inches or more in
length; it is cylindrical, tortuous, longitudinally furrowed, from
²/₁₀ to ⁷/₁₀ of an inch in thickness, mostly simple or provided with
a few thin rootlets emitting slender, branching woody aerial stems,
³/₀ of an inch or less thick. Externally it is dark brown, sometimes
with a slight violet-grey hue, which is particularly obvious in the
sunshine. The transverse section of the hard root shows a white mealy
or brownish or somewhat violet cortical layer, not exceeding ⅒ of an
inch in thickness, and a yellowish woody column, separated by a narrow
dark undulated cambial line. Neither the wood nor the cortical tissue
present a radiate structure in the stout pieces; in the thinner roots,
medullary rays are obvious in the woody part. The extremely thin corky
layer easily separates from the bark, which latter is frequently marked
transversely by large cracks. The root, whether fresh or dried, has
an agreeable odour resembling tonka bean or melilot. The dried root
has a sweetish taste with a very slight acidity. The stems are almost
tasteless and inodorous. The root found in the English market is often
of very bad quality.

[1563] _Yearbook of Pharm._ 1878. 624, from _Proc. of the American
Pharm. Association_, 1877.

[1564] Fig. in Bentley and Trimen, _Med. Plants_, part 6 (1876).

[1565] There is an Indian root figured as _Palo de Culebra_ by Acosta
(_Tractado de las Drogas ... de las Indias Orientales_, 1578, cap.
lv.) which is astonishingly like the drug in question. He describes
it moreover as having a sweet smell of melilot. The plant he says is
called in Canarese _Duda sali_. The figure is reproduced in Antoine
Colin’s translation, but not in that of Clusius.

[1566] _Lond. Med. and Phys. Journ._ lxv. 189.

[1567] Taken from excellent specimens obligingly sent to us from India
by Dr. L. W. Stewart and Mr. Broughton.

=Microscopic Structure=—All the proper cortical tissue shows a uniform
parenchyme, not distinctly separated into liber, medullary rays and
mesophlœum. On making a longitudinal section however, one can observe
some elongated laticiferous vessels filled with the colourless concrete
milky juice. In a transverse section, they are seen to be irregularly
scattered through the bark, chiefly in its inner layers, yet even
here in not very considerable number. They are frequently 30 mkm. in
diameter and not branched.

The wood is traversed by small medullary rays, which are obvious only
in the longitudinal section. The parenchymatous tissue of the root is
loaded with large, ovoid starch granules. Tannic matters do not occur
to any considerable amount, except in the outermost suberous layer.

=Chemical Composition=—The root has not been submitted to any adequate
chemical examination. Its taste and smell appear not to depend on the
presence of essential oil, so far as may be inferred from microscopic
examination; and it is probable the aroma is due to a body of the
cumarin class. According to Scott,[1568] the root yields by simple
distillation with water a stearoptene, which is probably the substance
obtained by Garden in 1837, and supposed to be a volatile acid.

=Uses=—The drug is reputed to be alterative, tonic, diuretic and
diaphoretic, but is rarely employed, at least in England.


CORTEX MUDAR.

_Cortex Calotropidis_; _Mudar_; F. _Ecorce de racine de Mudar_.

=Botanical Origin=—The drug under notice is furnished by two
nearly allied species of _Calotropis_, occupying somewhat distinct
geographical areas, but not distinguished from each other in the native
languages of India. These plants are:—

1. _Calotropis procera_ R. Brown (_C. Hamiltonii_ Wight), a large
shrub, 6 or more feet high, with dark green, oval leaves, downy
beneath, abounding in acrid milky juice.

It is a native of the drier parts of India, as the Deccan, the Upper
Provinces of Bengal, the Punjab and Sind, but is quite unknown in the
southern provinces; it also extends to Persia, Palestine, the Sinaitic
Peninsula, Arabia, Egypt, to the oasis Dachel, and other oases of the
Sahara, to Nubia, Abyssinia, the lake Tsad and through the Sudan.
Lastly it has been naturalized in the West Indies.

2. _C. gigantea_ R. Brown (_Asclepias gigantea_ Willd.), a large erect
shrub, 6 to 10 feet high, with stem as thick as a man’s leg,[1569] much
resembling preceding, indigenous to Lower Bengal and the southern parts
of India, Ceylon, the Malayan Peninsula, and the Moluccas.

Both species are extremely common in waste ground over their respective
areas.[1570]

[1568] _Pharm. of India_, 457; also _Chem. Gazette_, 1843. 378.

[1569] Hence the specific name _gigantea_.

[1570] The botanical distinctions between the two species may be stated
thus:—

_C. procera_, corolla cup-shaped, petals somewhat erect, flower-buds
spherical, appendages of corona with a blunt upward point. See Fig. in
Bentley and Trimen, _Med. Plants_, part 25 (1877).

_C. gigantea_, corolla opening flat, flower-buds bluntly conical or
oblong, appendages of corona rounded.

=History=—The ancient name of the plant, which occurs already in the
Vedic literature, was _Arka_ (wedge), alluding to the form of the
leaves which were used in sacrificial rites. From one of the Sanskrit
names of this plant, namely _Mandāra_, Mudar is a corruption;[1571] the
latter is frequently mentioned in the writings of Susruta.

The plant was likewise well known to the Arabian physicians.[1572]

_C. procera_ was observed in Egypt by Prosper Alpinus (1580-84), and
upon his return to Italy was figured, and some account given of its
medicinal properties.[1573] It is also the “Apocynum syriacum” figured
by Clusius.[1574]

_C. gigantea_ was figured by Rheede[1575] in 1679, and in our own day
by Wight.[1576]

The medicinal virtues of mudar, though so long esteemed by the natives
of India, were not investigated experimentally by Europeans until the
present century, when Playfair recommended the drug in elephantiasis,
and its good effects were afterwards noticed by Vos (1826), Cumin
(1827), and Duncan (1829). The last named physician also performed
a chemical examination of the root-bark, the activity of which he
referred to an extractive matter which he termed _Mudarine_.[1577]

=Description=—The root-bark of _C. procera_, as we have received
it,[1578] consists of short, arched, bent, or nearly flat fragments, ⅛
to ⅕ of an inch thick. They have outwardly a thickish, yellowish-grey,
spongy cork, more or less fissured lengthwise, frequently separating
from the middle cortical layer; the latter consists of a white mealy
tissue, traversed by narrow brown liber-rays. The bark is brittle and
easily powdered; it has a mucilaginous, bitter, acrid taste, but no
distinctive odour. The light yellow, fibrous wood is still attached to
many of the pieces.

The roots of _C. gigantea_ are clothed with a bark which seems to be
undistinguishable from that of _C. procera_ just described. The wood
of the root consists of a porous, pale yellow tissue, exhibiting large
vascular bundles, and very numerous small medullary rays, consisting of
1 to 3 rows of the usual cells.[1579]

[1571] Information for which we are indebted to Dr. Rice.

[1572] Ibn Baytar, translated by Sontheimer, ii. (1842) 193.

[1573] _De Plantis Ægypti_, Venet. 1592. cap. xxv.

[1574] _Rarior. plantar. hist._ ii. (1601) lxxxvii.

[1575] _Hortus Malabaricus_, ii. tab. 31.

[1576] _Illustrations of Indian Botany_, Madras, ii. (1850) tab.
155.—_C. procera_ is figured by the same author in his _Icones
Plantarum Indiæ Orientalis_, iv. tab. 1278.

[1577] _Edinb. Med. and Surg. Journ._ xxxii. (1829) 60.

[1578] We are indebted for an authentic specimen to Dr. E. Burton Brown
of Lahore.

[1579] Roots of _C. gigantea_ kindly supplied to us by Dr. Bidie of
Madras consist of light, woody truncheons, ½ to 2¼ inches in diameter.

=Microscopic Structure=—In the root-bark of _C. procera_, the suberous
coat is made up of large, thin-walled, polyhedral, or almost cubic
cells; the middle cortical layer, of a uniform parenchyme, loaded with
large starch granules, or here and there containing some thick-walled
cells (sclerenchyme) and tufts of oxalate of calcium. The large
medullary rays are built up of the usual cells, having porous walls and
containing starch and oxalate. In a longitudinal section, the tissue,
chiefly of the middle cortical layer, is found to be traversed by
numerous laticiferous vessels, containing the dry milk juice[1580] as a
brownish granular substance not soluble in potash.

The microscopic characters of the root-bark of _C. gigantea_ agree with
those here detailed of _C. procera_. The stems of _Calotropis_ are
distinguished by strong liber-fibres, which are not met with in the
roots.

=Chemical Composition=—By following the process of Duncan above
alluded to, 200 grammes of the powdered bark of _C. gigantea_ yielded
us nothing like his _Mudarine_, but 2·4 grammes of an acrid _resin_,
soluble in ether as well as in alcohol. The latter solution reddens
litmus; the former on evaporation yields the resin as an almost
colourless mass. If the aqueous liquid is separated from the crude
resin, and much absolute alcohol added, an abundant precipitate of
mucilage is obtained. The liquid now contains a bitter principle, which
after due concentration may be separated by means of tannic acid.

We obtained similar results by exhausting the bark of _C. procera_
with dilute alcohol. The tannic compound of the bitter principle was
mixed with carbonate of lead, dried and boiled with spirit of wine.
This after evaporation furnished an amorphous, very bitter mass, not
soluble in water, but readily so in absolute alcohol. The solution
is _not_ precipitated by an alcoholic solution of acetate of lead.
By purifying the bitter principle with chloroform or ether, it is at
last obtained colourless. This bitter matter is probably the active
principle of _Calotropis_; we ascertained by means of the usual tests
that no alkaloid occurs in the drug. The large juicy stem, especially
that of _C. gigantea_, ought to be submitted to an accurate chemical
and therapeutical examination.[1581]

=Uses=—Mudar is an alterative, tonic and diaphoretic,—in large doses
emetic. By the natives of India, who employ it in venereal and skin
complaints, almost all parts of the plant are used. According to
Moodeen Sheriff,[1582] the bark of the root and the dried milky juice
are the most efficient; the latter is however somewhat irregular and
unsafe in its action. The same writer remarks that he has found that
the older the plant, the more active is the bark in its effects. He
recommends that the corky outer coat, which is tasteless and inert,
should be scraped off before the bark is powdered for use: of a powder
so prepared, 40 to 50 grains suffice as an emetic.

The stems of _C. gigantea_ afford a very valuable fibre which can be
spun into the finest thread for sewing or weaving.[1583]

[1580] It is evidently with a view to the retention of this juice, that
the _Pharmacopœia of India_ orders the bark to be stripped from the
roots when the latter are half-dried. Moodeen Sheriff remarks of _C.
gigantea_, that although it is frequently used in medicine, no part
of it is sold in the bazaars,—no doubt from the circumstance that the
plant is everywhere found wild and can be collected as required.

[1581] List’s _Asclepione_ (Gmelin’s _Chemistry_, xvii. 368) might then
be sought for.

[1582] _Supplement to the Pharmacopœia of India_, Madras, 1869. 364;
for further information on the therapeutic uses of mudar, see also
_Pharm. of India_, 458.

[1583] Drury, _Useful Plants of India_, 2nd ed. 1873. 101.


FOLIA TYLOPHORÆ.

_Country or Indian Ipecacuanha_.

=Botanical Origin=—_Tylophora asthmatica_ Wight et Arnott (_Asclepias
asthmatica_ Roxb.), a twining perennial plant, common in sandy soils
throughout the Indian Peninsula and naturalized in Mauritius. It may be
distinguished from some of its congeners by its reddish or dull pink
flowers, with the scale of the staminal corona abruptly contracted into
a long sharp tooth.[1584]

=History=—The employment of this plant in medicine is well known to
the Hindus, who call it _Antamul_ and use it with considerable success
in dysentery, but we have not succeeded in tracing it in the ancient
Indian literature. During the last century it attracted the attention
of Roxburgh[1585] who made many observations on the administration of
the root, while physician to the General Hospital of Madras from 1776
to 1778. It was also used very successfully in the place of ipecacuanha
by Anderson, Physician-General to the Madras army.[1586] In more recent
times, the plant has been prescribed by O’Shaughnessy, who pronounced
the root an excellent substitute for ipecacuanha if given in rather
larger doses.[1587] Kirkpatrick[1588] administered the drug in at least
a thousand cases, and found it of the greatest value; he prescribed
the _dried leaf_, not only because superior to the root in certainty
of action, but also as being obtainable without destruction of the
plant. The drug has been largely given by many other practitioners in
India. _Tylophora_ is also employed in Mauritius, where it is known
as _Ipéca sauvage_ or _Ipéca du pays_. It has a place in the _Bengal
Pharmacopœia_ of 1844, and in the _Pharmacopœia of India_ of 1868.

=Description=[1589]—The leaves are opposite, entire, from 2 to 5 inches
long, ¾ to 2½ inches broad, somewhat variable in outline, ovate or
subrotund, usually cordate at the base, abruptly acuminate or almost
mucronate, rather leathery, glabrous above, more or less downy beneath
with soft simple hairs. The pedicel, which is channelled, is ½ to ¾ of
an inch in length. In the dry state the leaves are rather thick and
harsh, of a pale yellowish green; they have a not unpleasant herbaceous
smell, with but very little taste.[1590]

=Chemical Composition=—A concentrated infusion of the leaves has a
slightly acrid taste. It is abundantly precipitated by tannic acid, by
neutral acetate of lead or caustic potash, and is turned greenish-black
by perchloride of iron. Broughton of Ootacamund (India) has informed
us (1872) that from a large quantity of the leaves he obtained a small
amount of crystals,—insufficient for analysis. Dissolved and injected
into a small dog, they occasioned purging and vomiting.

[1584] Fig. in Bentley and Trimen, _Med. Plants_, part 29 (1878).

[1585] _Flora Indica_, ed. Carey, ii. (1832) 33.

[1586] Fleming, _Catalogue of Indian Plants and Drugs_, Calcutta, 1810.
8.

[1587] _Bengal Dispensatory_ (1842) 455.

[1588] _Catalogue of Madras Exhibition of 1855_,—list of Mysore drugs;
also _Pharm. of India_, 458.

[1589] Drawn up from an ample specimen kindly presented to us, together
with one of the root, by Mr. Moodeen Sheriff of Madras.

[1590] A figure of the leaves may be found in a paper on _Unto-mool_ by
M. C. Cooke, _Pharm. Journ._ Aug. 6, 1870. 105; and one of the whole
plant in Wight’s _Icones Plantarum Indiæ Orientalis_, iv. (1850) tab.
1277.

=Uses=—Employed in India, as already mentioned, as a substitute for
ipecacuanha, chiefly in the treatment of dysentery. The dose of the
powdered leaves as an _emetic_ is 25 to 30 grains, as a diaphoretic and
expectorant 3 to 5 grains.

_Radix Tylophoræ_—This root is met with in the Indian bazaars, and
has been employed, as before stated, as much or more than the leaf.
It consists of a short, knotty, descending rootstock, about ⅛ of an
inch in thickness, emitting 2 to 3 aerial stems, and a considerable
number of wiry roots. These roots are often 6 inches or more in length
by ½ a line in diameter, and are very brittle. The whole drug is of a
pale yellowish-brown; it has no considerable odour, but a sweetish and
subsequently acrid taste. In general appearance it is suggestive of
valerian, but is somewhat stouter and larger.

Examined microscopically, the parenchymatous envelope of the rootlets
is seen to consist of two layers, the inner forming a small nucleus
sheath. The outer portion is built up of large cells, loaded with
starch granules and tufted crystals of oxalate of calcium. Salts of
iron do not alter the tissue.




LOGANIACEÆ.


=NUX VOMICA.=

_Semen Nucis Vomicæ_; _Nux Vomica_; F. _Noix vomique_; G. _Brechnuss_.

=Botanical Origin=—_Strychnos Nux vomica_ L., a moderate sized tree
with short, thick, often crooked stem, and small, greenish-white,
tubular flowers ranged in terminal corymbs. It is indigenous to most
parts of India, especially the coast districts, and is found in Burmah,
Siam, Cochin China and Northern Australia.

The ovary of _S. Nux vomica_ is bilocular, but as it advances in growth
the dissepiment becomes fleshy and disappears. The fruit, which is an
indehiscent berry of the size and shape of a small orange, is filled
with a bitter, gelatinous white pulp, in which the seeds, 1 to 5 in
number, are placed vertically in an irregular manner. The epicarp forms
a thin, smooth, somewhat hard shell, which at first is greenish, but
when mature, of a rich orange-yellow. The pulp of the fruit contains
strychnine,[1591] yet it is said to be eaten in India by birds.[1592]
The wood, which is hard and durable, is very bitter.

[1591] Roxburgh’s assertion that the pulp “_seems perfectly innocent_,”
induced us to examine it chemically, which we were enabled to do
through the kindness of Dr. Thwaites, of the Royal Botanical Gardens,
Ceylon. The _inspissated pulp_ received from Dr. T., diluted with
water, formed a very consistent jelly having a slightly acid reaction
and very bitter taste. Some of it was mixed with slaked lime,
dried, and then exhausted by boiling chloroform. The liquid left on
evaporation a yellowish resinoid mass, which was warmed with acetic
acid. The colourless solution yielded a perfectly white, crystalline
residue, which was dissolved in water, and precipitated with bichromate
of potassium. The crystallized precipitate dried, and moistened with
strong sulphuric acid, exhibited the violet hue characteristic of
strychnine.

To confirm this experiment, we obtained through the obliging assistance
of Dr. Bidie of Madras, some of the white pulp taken with a spoon from
the interior of the ripe fruit, and at once immersed _per se_ in spirit
of wine. The alcoholic fluid gave abundant evidence of the presence of
strychnine.

[1592] According to Cleghorn by the hornbill (_Buceros malabaricus_);
according to Roxburgh by “many sorts of bird.” Beddome (_Flora
Sylvatica_, Madras, 1872. 243) says the pulp is quite harmless, and the
favourite food of many birds.

In Garnier, _Exploration en Indo-China_ ii. (Paris, 1873) 488, allusion
is made to a tree similar to that under notice having fruits which are
devoid of poison _before maturity_.

=History=—Nux Vomica, which was unknown to the ancients, is thought to
have been introduced into medicine by the Arabians. But the notices in
their writings which have been supposed to refer to it, are far from
clear and satisfactory. We have no evidence moreover that it was used
in India at an early period. Garcia de Orta, an observer thoroughly
acquainted with the drugs of the west coast of India in the middle of
the 16th century, is entirely silent as to nux vomica. Fleming,[1593]
writing at the beginning of the present century, remarks that nux
vomica is seldom, if ever, employed in medicine by the Hindus, but this
statement does not hold good now.

The drug was however certainly made known in Germany in the 16th
century. Valerius Cordus[1594] wrote a description of it about the year
1540, which is remarkable for its accuracy. Fuchs, Bauhin and others
noticed it as _Nux Metella_, a name taken from the _Methel_ of Avicenna
and other Arabian authors.[1595]

It was found in the English shops in the time of Parkinson (1640), who
remarks that its chief use is for poisoning dogs, cats, crows, and
ravens, and that it is rarely given as a medicine.

=Description=—Nux Vomica is the _seed_, removed from the pulp and
shell. It is disc-like, or rather irregularly orbicular, a little less
than an inch in diameter, by about a quarter of an inch in thickness,
slightly concave on the dorsal, convex on the ventral surface, or
nearly flat on either side, often furnished with a broad, thickened
margin so that the central portion of the seed appears depressed.
The outside edge is rounded or tapers into a keel-like ridge. Each
seed has on its edge a small protuberance, from which is a faintly
projecting line (raphe) passing to a central scar, which is the hilum
or umbilicus; a slight depression marks the opposite side of the seed.
The seeds are of a light greyish hue, occasionally greenish, and have a
satiny or glistening aspect, by reason of their being thickly covered
with adpressed, radiating hairs. Nux vomica is extremely compact and
horny, and has a very bitter taste.

After having been softened by digestion in water, the seed is easily
cut along its outer edge, then displaying a mass of translucent,
cartilaginous albumen, divided into two parts by a fissure in which
lies the embryo. This latter is about ³/₁₀ of an inch long, having
a pair of delicate 5-to 7-nerved, heart-shaped cotyledons, with a
club-shaped radicle, the position of which is indicated on the exterior
of the seed by the small protuberance already named.

[1593] _Catalogue of Indian Med. Plants and Drugs_, Calcutta, 1810. 37.

[1594] _Hist. Stirpium_, edited by C. Gesner, Argentorat. 1561. lib.
iv. c. 21.

[1595] Clusius and others held the opinion that the _Nux methel_ of
the Arabs was the fruit of a _Datura_, and an Indian species was
accordingly named by Linnæus _D. Metel_.

=Microscopic Structure=—The hairs of nux vomica are of remarkable
structure. They are formed as usual of the elongated cells of the
epidermis, and have their walls thickened by secondary deposits, which
are interrupted by longitudinally extended pores; they are a striking
object in polarized light. The albumen is made up of large cells,
loaded with albuminoid matters and oily drops, but devoid of starch.
In water the thick walls of this parenchyme swell up and yield some
mucilage; the cotyledons are built up of a narrow, much more delicate
tissue, traversed by small fibro-vascular bundles.

The alkaloids are not directly recognizable by the microscope; but if
very thin slices of nux vomica are kept for some length of time in
glycerin, they develop feathery crystals, doubtless consisting of these
bases.

=Chemical Composition=—The bitter taste and highly poisonous action
of nux vomica are chiefly due to the presence of _Strychnine_ and
_Brucine_. Strychnine, C₂₁H₂₂N₂O₂, was first met with in 1818 by
Pelletier and Caventou in St. Ignatius’ Beans, and immediately
afterwards in nux vomica. It crystallizes from an alcoholic solution
in large anhydrous prisms of the orthorhombic system. It requires
for solution about 6700 parts of cold or 2500 of boiling water; the
solution is of decidedly alkaline reaction, and an intensely bitter
taste which may be distinctly perceived though it contain no more than
¹/₆₀₀₀₀₀ of the alkaloid. The best solvents for strychnine are spirit
of wine or chloroform; it is but very sparingly soluble in absolute
alcohol, benzol, amylic alcohol, or ether. The alcoholic solution
deviates the ray of polarized light to the left.

Strychnine is not restricted to the fruit of the plant under notice,
but also occurs in the wood and bark.[1596] It is moreover found in
the wood of the root of _Strychnos colubrina_ L., and in the bark of
the root of _Strychnos Tieute_ Lesch., both species indigenous to the
Indian Archipelago.

The discovery of _Brucine_ was made in 1819 by the same chemists, in
nux vomica bark, then supposed to be derived from _Brucea ferruginea_
Héritier (_B. antidysenterica_ Miller), an Abyssinian shrub of the
order Simarubeæ. The presence of brucine in nux vomica and St.
Ignatius’ Bean was pointed out by them in 1824. Brucine, dried over
sulphuric acid, has the formula C₂₃H₂₆N₂O₄, but it crystallizes
from its alcoholic solution with 4 OH₂. In bitterness and poisonous
properties, as well as in rotatory power, it closely resembles
strychnine, differing however in the following particulars:—it is
soluble in about 150 parts of boiling water, melts without alteration a
little above 130° C. In common with its salts, it acquires a dark red
colour when moistened with concentrated nitric acid.

The proportion of strychnine in nux vomica appears to vary from ¼ to ½
per cent. That of brucine is variously stated to be 0·12 (Merck), 0·5
(Wittstein), 1·01 (Mayer) per cent.

A third crystallizable base, called _Igasurine_, was stated in 1853 by
Desnoix to occur in the liquors from which strychnine and brucine had
been precipitated by lime. Schützenberger’s investigations (1858) are
far from proving the existence of “igasurine.”[1597]

[1596] It is remarkable that parasitic plants of the order
_Loranthaceæ_ growing on _Strychnos Nux vomica_ acquire the poisonous
properties of the latter.—_Pharm. of India_, 1868. 108.

[1597] For further information on igasurine, consult Gmelin,
_Chemistry_, xvii. (1866) 589; Watts, _Dictionary of Chemistry_, iii.
(1865) 243; _Pharm. Journ._ xviii. (1859) 432.

In nux vomica, as well as in St. Ignatius’ Beans, the alkaloids,
according to their discoverers, are combined with _Strychnic_ or
_Igasuric Acid_; Ludwig (1873), who prepared this body from the latter
drug, describes it as a yellowish-brown amorphous mass, having a
strongly acid reaction and a sour astringent taste, and striking a
dark green with ferric salts. We have ascertained the correctness of
Ludwig’s observations.

Nux vomica dried at 100° C. yielded us when burnt with soda-lime 1·822
per cent. of nitrogen, indicating about 11·3 per cent. of protein
substances. By boiling ether, we removed from the seeds 4·14 per cent.
of fat; Meyer[1598] found it to yield butyric, capronic, caprylic,
caprinic and other acids of the series of the common fatty acids, and
also one acid richer in carbon than stearic acid. Nux vomica also
contains mucilage and sugar. The latter, which according to Rebling
(1855) exists to the extent of 6 per cent., reduces cupric oxide
without the aid of heat. When macerated in water, the seeds easily
undergo lactic fermentation, not however attended with decomposition of
the alkaloids. The stability of strychnine is remarkable, even after
ten years of contact with putrescent animal substances.

=Commerce=—Large quantities of nux vomica are brought into the London
market from British India.[1599] The export from Bombay in the year
1871-72 was 3341 cwt., all shipped to the United Kingdom.[1600] Madras
in 1869-70 exported 4805 cwt.; and Calcutta in 1865-66, 2801 cwt. The
quantity imported into the United Kingdom in 1870[1601] was 5534 cwt.

Nux vomica is stated by Garnier (_l.c._ page 429, note) to be largely
exported from Cambodja to China.

=Uses=—Tincture and extract of nux vomica, and the alkaloid strychnine,
are frequently administered as tonic remedies in a variety of disorders.


SEMEN IGNATII.

_Faba Sancti Ignatii_; _St. Ignatius’ Beans_; F. _Fèves de Saint
Ignace_, _Noix Igasur_; G. _Ignatiusbohnen_.[1602]

[1598] _Jahresbericht der Chemie_, 1875. 856.

[1599] We have seen 1136 packages offered in a single drug sale (30
March 1871).

[1600] _Statement of the Trade and Navigation of Bombay for 1871-72_,
pt. ii. 62.

[1601] No later returns are accessible.

[1602] The plant and seeds are known in the Bisaya language by the
names of _pangaguason_, _aguason_, _canlara_, _mananaog_, _dancagay_,
_catalonga_ or _igasur_; in the islands of Bohol and Çebu, where the
seeds are produced, by that of _coyacoy_, and by the Spaniards of the
Philippines as _Pepita de Bisaya_ or _Pepita de Catbalogan_ (Clain,
_Remedios Faciles_, Manila, 1857. p. 610). The name _St. Ignatius’
Bean_ applied to them in Europe, is employed in South America to
designate the seeds of several medicinal _Cucurbitaceæ_, as those of
_Fenillea trilobata_ L., _Hypanthera Guapeva_ Manso and _Anisosperma
Passiflora_ Manso.

=Botanical Origin=—_Strychnos Ignatii_ Bergius[1603] (_S. philippensis_
Blanco, _Ignatiana philippinica_ Loureiro), a large climbing shrub,
growing in Bohol, Samar, and Çebu, islands of the Bisaya group of the
Philippines, and according to Loureiro in Cochin China, where it has
been introduced. The inflorescence and foliage are known to botanists
only from the descriptions given by Loureiro[1604] and Blanco.[1605]
The fruit is spherical, or sometimes ovoid, 4½ inches in diameter by
6¾ long, as shown by Ray and Petiver’s figure. It has a smooth brittle
shell enclosing seeds to the number of about 24. G. Bennett,[1606] who
saw the fruits at Manila sold in the bazaar, says they contain from 1
to 12 seeds, imbedded in a glutinous blackish pulp.[1607] According to
Jagor[1608] the shrub is abundant near Basey, in the south-western part
of the island of Samar, on the straits of San Juanico; its seeds are
met with as a medicine in many houses in the Philippines.

=History=—It is stated by Murray[1609] and later writers that this seed
was introduced into Europe from the Philippines by the Jesuits, who,
on account of its virtues, bestowed upon it the name of Ignatius, the
founder of their order. However this may be, the earliest account of
the drug appears to be that communicated by Camelli, Jesuit missionary
at Manila, to Ray and Petiver, and by them laid before the Royal
Society of London in 1699.[1610] Camelli proclaimed the seed to be the
_Nux Vomica legitima_ of the Arabian physician Serapion, who flourished
in the 9th century; but in our opinion there is no warrant whatever
for supposing it to have been known at so remote a period.[1611]
_Sancti Ignatii_, is much esteemed as a remedy in various disorders,
though he was well aware of its poisonous properties when too freely
administered. In Germany, St. Ignatius’ Bean was made known about the
same period by Bohn of Leipzig.[1612]

The drug is found in the Indian bazaars under a name which is evidently
corrupted from the Spanish _pepita_. It is met with in the drugshops of
China as _Leu-sung-kwo_, i.e. _Luzon fruit_.

=Description=—St. Ignatius’ Beans are about an inch in length; their
form is ovoid, yet by mutual pressure it is rendered very irregular,
and they are 3-, 4-, or 5-sided, bluntly angular, or flattish, with a
conspicuous hilum at one end. In the fresh state, they are covered with
silvery adpressed hairs: portions of a shaggy brown epidermis are here
and there perceptible on those found in commerce, but in the majority
the seed shows the dull grey, granular surface of the albumen itself.

Notwithstanding the different outward appearance, the structure of St.
Ignatius’ Beans accords with that of nux vomica. The radicle however
is longer, thicker, and frequently somewhat bent, and the cotyledons
are more pointed. The horny brownish albumen is translucent, very hard,
and difficult to split. The whole seed swells considerably by prolonged
digestion in warm water, and has then a heavy, earthy smell. The beans
are intensely bitter and highly poisonous.

[1603] _Materia Medica_, Stockholm, 1778. i. 146.—We omit citing the
Linnean _Ignatia amara_, as it has been shown by Bentham that the plant
so named by the younger Linnæus is _Posoqueria longiflora_ Aubl. of the
order _Rubiaceæ_, a native of Guiana.

[1604] _Flora Cochinchinensis_, ed. Willd. i. (1793) 155.

[1605] _Flora de Filipinas_, ed. 2. 1845. 61.

[1606] _London Med. and Phys. Journ._ January 1832.

[1607] The only specimen of the fruit I have seen was in the possession
of my late friend Mr. Morson. It measured exactly 4 inches in diameter,
and when opened (15 January 1872) was found to contain 17 mature,
well-formed seeds, with remnants of dried pulp.—D. H. I have seen
another one in the Jardin des Plantes, Paris.—F. A. F..

[1608] _Reisen in den Philippinen_, Berlin, 1873. 213.

[1609] _Apparatus Medicaminum_, vi. (1792) 26.

[1610] _Phil. Trans._, xxi. (1699) 44. 87; Ray, _Hist. Plant._ iii.
lib. 31. 118.

[1611] The Philippines were unknown to the Europeans of the Middle
Ages. They were discovered by Magellan in 1521, but their conquest by
the Spaniards was not effectually commenced until 1565. Previous to
the Spanish occupation, they were governed by petty chiefs, and were
frequented for the purposes of commerce by Japanese, Chinese, and
Malays.

[1612] Martiny, _Encyklopädie der Rohwaarenkunde_, i. (1843) 576.

=Microscopic Structure=—The hairs of the epidermis are of an analogous
structure, but more simple than in nux vomica. The albumen and
cotyledons agree in structural features with those of the same parts in
nux vomica.

=Chemical Composition=—Strychnine exists to the extent of about 1·5
per cent.; the seeds also contain 0·5 per cent. of brucine. Dried over
sulphuric acid and burnt with soda-lime, it yielded us an average of
1·78 per cent. of nitrogen, which would answer to about 10 per cent. of
albuminoid matter.

=Commerce=—We have no information as to the collection of the drug. The
seeds are met with irregularly in English trade, being sometimes very
abundant, at others scarcely obtainable.

=Uses=—The same as those of nux vomica. When procurable at a moderate
price, the seeds are valued for the manufacture of strychnine.


RADIX SPIGELIÆ.

_Radix Spigeliæ Marilandicæ_; _Indian Pink Root_, _Carolina Pink Root_,
_Spigelia_.[1613]

=Botanical Origin=—_Spigelia marilandica_ L., an herbaceous plant
about a foot high, indigenous in the woods of North America, from
Pennsylvania to Wisconsin and southward. According to Wood and Bache,
it is collected chiefly in the Western and South-western States.

[1613] _Pink Root_ is sometimes erroneously latinized in price-lists,
“_Radix caryophylli_.”

=History=—The anthelminthic properties of the root, discovered by
the Indians, were brought to notice in Europe about the year 1754
by Linning, Garden, and Chalmers, physicians of Charleston, South
Carolina. The drug was admitted to the London Pharmacopœia in 1788.

=Description=—Pink root has a near resemblance to serpentary,
consisting of a short, knotty, dark brown rhizome emitting slender
wiry roots. It is quite wanting in the peculiar odour of the latter
drug, or indeed in any aroma; in taste it is slightly bitter and
acrid. Sometimes the entire plant with its quadrangular stems a foot
high is imported. It has opposite leaves about 3 inches long, sessile,
ovate-lanceolate, acuminate, smooth or pubescent.

=Microscopic Structure=—The transverse section of the rhizome, about
²/₁₀ of an inch in diameter, shows a small woody zone enclosing a large
pith of elliptic outline, consisting of thin-walled cells. Usually the
central tissue is decayed. In the roots, the middle cortical layer
predominates; it swells in water, after which its large cells display
fine spiral markings. The nucleus-sheath observable in serpentary is
wanting in spigelia.

=Chemical Composition=—Not satisfactorily known: the vessels of the
wood contain resin, the parenchyme starch; in the cortical part of the
rhizome some tannic matters occur, but not in the roots. Feneulle
(1823) asserts that the drug yields a little essential oil. The
experiments of Bureau[1614] show that spigelia acts on rabbits and
other animals as a narcotico-acrid poison.

=Uses=—Spigelia has long been reputed a most efficient medicine for the
expulsion of _Ascaris lumbricoides_, but according to Stillé,[1615]
its real value for this purpose has probably been over-estimated. This
author speaks of it as possessing alterative and tonic properties. In
England, it is rarely prescribed by the regular practitioner, but is
used as a household medicine in some districts. It is much employed in
the United States.




GENTIANEÆ.


RADIX GENTIANÆ.

_Gentian Root_; F. _Racine de Gentiane_; G. _Enzianwurzel_.

=Botanical Origin=—_Gentiana lutea_ L., a handsome perennial herb,
growing 3 feet high, indigenous to open grassy places on the mountains
of Middle and Southern Europe. It occurs in Portugal, Spain, the
Pyrenees, in the islands of Sardinia and Corsica, in the Apennines,
the mountains of Auvergne, the Jura, the Vosges, the Black Forest, and
throughout the chain of the Alps as far as Bosnia and the Danubian
Principalities. Among the mountains of Germany, it is found on the
Suabian Alps near Würzburg, and here and there in Thuringia, but not
further north, nor does it occur in the British Islands.

=History=—The name _Gentiana_ is said to be derived from Gentius, a
king of the Illyrians, living B.C. 180-167, by whom, according to both
Pliny and Dioscorides, the plant was noticed. Whether the species thus
named was _Gentiana lutea_ is doubtful. During the middle ages, gentian
was commonly employed for the cure of disease, and as an antidote to
poison. Tragus in 1552 mentions it as a means of diluting wounds, an
application which has been resorted to in modern medical practice.

=Description=—The plant has a cylindrical, fleshy, simple root, of pale
colour, occasionally almost as much as 4 feet in length by 1½ inches in
thickness, producing 1 to 4 aerial stems.

The dried root of commerce is in irregular, contorted pieces, several
inches in length, and ½ to 1 inch in thickness; the pieces are much
wrinkled longitudinally, and marked transversely, especially in their
upper portion, with numerous rings. Very often they are split to
facilitate drying. They are of a yellowish-brown; internally of a
more orange tint, spongy, with a peculiar, disagreeable, heavy odour,
and intensely bitter taste. The crown of the root, which is somewhat
thickened, is clothed with the scaly bases of leaves. The root is tough
and flexible,—brittle only immediately after drying. We found it to
lose in weight about 18 per cent.; by complete drying in a water-bath
it regained 16 per cent. by being afterwards exposed to the air.

[1614] _De la famille des Loganiacées_, 1856. 130.

[1615] _Therapeutics and Materia Medica_, Philadelphia, ii. (1868) 651.

=Microscopic Structure=—A transverse section shows the bark separated
by a dark cambial zone from the central column; the radial arrangement
of the tissues is only obvious in the latter part. In the bark,
liber-fibres are wanting; and in the centre there is no distinct
pith. The fibro-vascular bundles are devoid of thick-walled ligneous
prosenchyme; this may explain the consistence, and the short even
fracture of the root. It is moreover remarkable on account of the
absence both of starch and oxalate of calcium; the cells appear to
contain chiefly sugar and a little fat oil.

=Chemical Composition=—The bitter taste of gentian is due to a
substance called _Gentiopicrin_ or _Gentian-bitter_, C₂₀H₃₀O₁₂.
Several chemists, as Henry, Caventou, Trommsdorff, Leconte and Dulk
have described the bitter principle of gentian in an impure state,
under the name of _Gentianin_, but Kromayer in 1862 first obtained it
in a state of purity. Gentiopicrin is a neutral body crystallizing in
colourless needles, which readily dissolve in water. It is soluble
in spirit of wine, but in absolute alcohol only when aided by heat;
it does not dissolve in ether. A solution of caustic potash or soda
forms with it a yellow solution. Under the influence of a dilute
mineral acid, gentiopicrin is resolved into glucose, and an amorphous,
yellowish-brown, neutral substance, named _Gentiogenin_. Fresh gentian
roots yield somewhat more than ⅒ per cent. of gentiopicrin; from the
dried root it could not be obtained in a crystallized state. The
medicinal Tincture of Gentian, mixed with solution of caustic potash,
loses its bitterness in a few days, probably in consequence of the
destruction of the gentiopicrin.

Another constituent of gentian root is _Gentianin_ or _gentisin_

                                  {CH₃
    C₁₄H₁₀O₅ or (OH)₂C₆H₃·CO·C₆H₂  {O \.
                                  {O /

It forms tasteless yellowish prisms, sparingly soluble in alcohol,
requiring about 5000 parts of water for solution. With alkalis it
yields intensely yellow crystallizable compounds, which, however,
are easily decomposed already by carbonic acid. Gentianin may be
sublimed if carefully heated at 250° C. By melting it with caustic
potash, acetic acid, phloroglucin, C₆H₃(OH)₃, and oxysalicylic acid,
C₆H₃(OH)₂COOH, are produced, as shown in 1875 by Hlasiwetz and
Habermann. The name of _gentianic acid_ or _gentisinic acid_ had been
applied to the oxysalicylic acid obtained by the above decomposition
before it was identified with oxysalicylic acid from other sources.

Gentian root abounds in pectin; it also contains, to the extent of 12
to 15 per cent., an uncrystallizable sugar, of which advantage is taken
in Southern Bavaria and Switzerland for the manufacture by fermentation
and distillation of a potable spirit.[1616] This use of gentian and its
consumption in medicine have led to the plant being almost extirpated
in some parts of Switzerland where it formerly abounded.

The experiments of Maisch (1876) and Ville (1877) have shown tannic
matters to be absent from the root.

=Commerce=—Gentian root finds its way into English commerce through
the German houses; and some is shipped from Marseilles. The quantity
imported into the United Kingdom in 1870 was 1100 cwt.

[1616] Th. Martius, _Pharm. Journ._ xii. (1853) 371.

=Uses=—Gentian is much used in medicine as a bitter tonic. Ground to
powder, the root is an ingredient in some of the compositions sold for
feeding cattle.

=Substitutes=—It can hardly be said that gentian is adulterated, yet
the roots of several other species possessing similar properties are
occasionally collected; of these we may name the following:—

1. _Gentiana purpurea_ L.—This species is found in Alpine meadows
of the Apennines, Savoy and Switzerland, in Transylvania, and in
South-western Norway; a variety also in Kamtchatka.[1617] The root is
frequently collected;[1618] it attains at most 18 inches in length and
a diameter of about 1 inch at the summit, from which arise 8 to 10
aerial stems, clothed below with many scaly remains of leaves. The top
of the root has thus a peculiar branched appearance, never found in
the root of _G. lutea_, with which in all other respects that of _G.
purpurea_ agrees. The latter is perhaps even more intensely bitter.

2. _G. punctata_ L.—Nearly the same description applies to this
species, which is a native of the Alps of South-Eastern France, Savoy,
the southern parts of Switzerland, extending eastward to Austria,
Hungary and Roumelia.

3. _G. pannonica_ Scop.—a plant of the mountains of Austria, unknown
in the Swiss Alps, has a root which does not attain the length or the
thickness of the root of _G. purpurea_, with which it agrees in other
respects. It is officinal in the Austrian Pharmacopœia.

4. _G. Catesbœi_ Walter (_G. Saponaria_ L.)—indigenous in the United
States. Its root, usually not exceeding 3 inches in length by ⅓ inch in
diameter, has a very thin woody column within a spongy whitish cortical
tissue and a bright yellow epidermis. This root is less bitter than the
above enumerated drugs; the same remark applies also to those European
Gentianæ which like _G. Catesbœi_ are provided with blue flowers.


HERBA CHIRATÆ.

_Herba Chirettæ vel Chiraytæ_; _Chiretta or Chirayta_.

=Botanical Origin=—_Ophelia[1619] Chirata_ Grisebach (_Gentiana
Chirayita_ Roxb.), an annual herb of the mountainous regions of
Northern India from Simla through Kumaon to the Murung district in
South-eastern Nepal.

=History=—Chiretta has long been held in high esteem by the Hindus, and
is frequently mentioned in the writings of Susruta. It is called in
Sanscrit _Kirāta-tikta_, which means the _bitter plant of the Kirātus_,
the Kirātas being an outcast race of mountaineers in the north of
India. In England, it began to attract some attention about the year
1829; and in 1839 was introduced into the Edinburgh Pharmacopœia. The
plant was first described by Roxburgh in 1814.

[1617] Grisebach (_Die Vegetation der Erde_, i. 1872. 223) gives very
interesting particulars relating to the area of growth of _Gentiana
purpurea_, _G. punctata_ and _G. pannonica_. He is decidedly of the
opinion that they are distinct species.

[1618] In Norway it is, strange to say, called sweetroot, “_Sötrot_,”
according to Schübeler, _Pflanzenwelt Norwegens_, 1873-1875, p. 259.

[1619] Ὀϕέλλειν, to bless, in allusion to the medical virtues of the
herb.—Fig. in Bentley and Trimen, _Med. Plants_, part 7 (1876).

Chiretta was regarded by Guibourt as the _Calamus aromaticus_ of the
ancients, but the improbability of this being correct was well pointed
out by Fée[1620] and by Royle, and is now generally admitted.

=Description=—The entire plant is collected when in flower, or more
commonly when the capsules are fully formed, and tied up with a slip
of bamboo into flattish bundles of about 3 feet long,[1621] each
weighing when dry from 1½ to 2 lb. The stem, ²/₁₀ to ³/₁₀ of an inch
in thickness, is of an orange-brown, sometimes of a dark purplish
colour; the tapering simple root, often much exceeding the stem in
thickness, is 2 to 4 inches long and up to ½ an inch thick. It is
less frequently branched, but always provided with some rootlets.
In stronger specimens, the root is somewhat oblique or geniculate;
perhaps the stem is in this case the product of a second year’s growth
and the plant not strictly annual. Each plant usually consists of a
single stem, yet occasionally two or more spring from a single root.
The stem rises to a height of 2 to 3 feet, and is _cylindrical in its
lower and middle portion_, but bluntly quadrangular in its upper,
the four edges being each marked with a prominent decurrent line,
as in _Erythræa Centaurium_ and many other plants of the order. The
decussate ramification resembles that of other gentians; its stems
are jointed at intervals of 1½ to 3 or 4 inches, bearing opposite
semi-amplexicaul leaves on their cicatrices. The stem consists in its
lower portion of a large woody column, coated with a very thin rind,
and enclosing a comparatively large pith. The upper parts of the stem
and branches contain a broad ring of thick-walled woody parenchyme. The
numerous slender axillary and opposite branches are elongated, and thus
constitute a dense umbellate panicle. They are smooth and glabrous, of
a greenish or brownish grey colour.

The leaves are ovate-acuminate, cordate at the base, entire, sessile,
the largest 1 inch or more in length, 3-to 5-or 7-nerved, the midrib
being strongest. At each division of the panicle there are two small
bracts. The yellow corolla is rotate, 4-lobed, with glandular pits
above the base; the calyx is one-third the length of the petals, which
are about half an inch long. The one-celled, bivalved capsule contains
numerous seeds.

The flowers share the intense bitterness of the whole drug. The wood of
stronger stems is devoid of the bitter principles.

=Chemical Composition=—A chemical examination of chiretta has been made
at our request under the direction of Professor Ludwig of Jena, by his
assistant Mr. Höhn. The chief results of this careful and elaborate
investigation may be thus described.[1622]

Among the bitter principles of the drug, _Ophelic Acid_, C₁₃H₂₀O₁₀,
occurs in the largest proportion. It is an amorphous, viscid, yellow
substance, of an acidulous, persistently bitter taste, and a faint
gentian-like odour. With basic acetate of lead, it produces an abundant
yellow precipitate. Ophelic acid does not form an insoluble compound
with tannin; it dissolves in water, alcohol and ether. The first
solution causes the separation of protoxide of copper from an alkaline
tartrate of that metal.

[1620] _Cours d’Histoire nat. pharmaceutique_, ii. (1828) 395.

[1621] The other kinda of chiretta to be named presently are usually
much shorter.

[1622] For full details, see _Archiv der Pharmacie_, 189 (1869) 229.

A second bitter principle, _Chiratin_, C₂₆H₄₈O₁₅, may be removed by
means of tannic acid, with which it forms an insoluble compound.
Chiratin is a neutral, not distinctly crystalline, light yellow,
hygroscopic powder, soluble in alcohol, ether and in warm water. By
boiling hydrochloric acid, it is decomposed into _Chiratogenin_,
C₁₃H₂₄O₃, and ophelic acid. Chiratogenin is a brownish, amorphous
substance, soluble in alcohol but not in water, nor yielding a tannic
compound. No sugar is formed in this decomposition.

These results exhibit no analogy to those obtained in the analysis
of the European gentians. Finally, Höhn remarked in chiretta a
crystallizable, tasteless, yellow substance, but its quantity was so
minute that no investigation of it could be made.

The leaves of chiretta, dried at 100° C., afforded 7·5 per cent. of
ash; the stems 3·7; salts of potassium and calcium prevailing in both.

=Uses=—Chiretta is a pure bitter tonic, devoid of aroma and
astringency. In intense bitterness it exceeds gentian, _Erythræa_ and
other European plants of the same order. It is much valued in India,
but is not very extensively used in England, and not at all on the
Continent. It is said to be employed when cheap, in place of gentian,
to impart flavour to the compositions now sold as _Cattle Foods_.

=Substitutes and Adulteration=—Some other species of _Ophelia_, namely,
_O. angustifolia_ Don, _O. densifolia_ Griseb., _O. elegans_ Wight,
_O. pulchella_ Don, and _O. multiflora_ Dalz, two or three species of
_Exacum_, besides _Andrographis paniculata_ Wall., are more or less
known in the Indian bazaars by the name of _Chiretta_[1623] and possess
to a greater or less degree the bitter tonic properties of that drug.
Another _Gentianacea_, _Slevogtia orientalis_ Griseb., is called _Chota
Chiretta_, i.e. _small chiretta_. It would exceed due limits were we
to describe each of these plants: we have therefore given a somewhat
detailed description of the true chiretta, which will suffice for its
identification. We have frequently examined the chiretta found in the
English market, but have never met with any other than the legitimate
sort.[1624] Bentley noticed in 1874 the substitution of _Ophelia
angustifolia_, which he found to be by far less bitter than true
chiretta.




CONVOLVULACEÆ.


SCAMMONIUM.

_Scammony_; F. _Scammonée_; G. _Scammonium_.

=Botanical Origin=—_Convolvulus Scammonia_ L., a twining plant much
resembling the common _C. arvensis_ of Europe, but differing from it
in being of larger size, and having a stout tap-root. It occurs in
waste bushy places in Syria, Asia Minor, Greece, the Greek Islands,
extending northward to the Crimea and Southern Russia, but appears to
be wanting in Northern Africa, Italy, and in all the western parts of
the Mediterranean basin.

[1623] Moodeen Sheriff, _Suppl. to the Pharmacopœia of India_, 1869.
pp. 138. 189.—Consult also _Pharmacopœia of India_, 1868. pp. 148-9.

[1624] Mr. E. A. Webb has pointed out a case of false-packing in which
the roots of _Rubia cordifolia_ L. (_Munjit_) had been enclosed in the
bundles of chiretta.

=History=—The dried milky juice of the scammony plant has been known
as a medicine from very ancient times. Theophrastus in the 3rd century
B.C. was acquainted with it; it was likewise familiar to Dioscorides,
Pliny, Celsus, and Rufus of Ephesus, each of whom has given some
account of the manner in which it was collected. Scammony used then
also to be called _Diagrydion_, from the Greek word δάκρυ, tear. The
mediæval Arabian physicians also knew scammony and the plant from
which it is derived. The drug was used in Britain in the 10th and 11th
centuries, and would appear to be one of the medicines recommended
to King Alfred the Great, by Helias, patriarch of Jerusalem.[1625]
It is repeatedly named in the medical writings in use prior to the
Norman conquest (A.D. 1066), in one of which directions are given for
recognizing the goodness of the drug by the white emulsion it produces
when wetted.

The botanists of the 16th and 17th centuries, as Brunfels, Gesner,
Matthiolus, Dodonæus, and the Bauhins, described and figured the plant
partly under the name of _Scammonia syriaca_. The collecting of the
drug was well described by Russell, an English physician of Aleppo
(1752), whose account[1626] is accompanied by an excellent figure
representing the plant and the means of obtaining its juice.

[1625] Such is the opinion expressed by the Rev. O. Cockayne. The
letter of Helias to Alfred is imperfect, and mentions only balsam,
petroleum, theriaka, and a white stone used as a charm. But from
the reference to these four articles in another part of the MS., in
connection with scammony, ammoniacum, tragacanth, and galbanum, there
is ground for believing that the latter (Syrian and Persian) drugs were
included in the lost part of the patriarch’s letter.—See _Leechdoms,
Wortcunning and Starcraft of Early England_, edited by Cockayne (Master
of the Rolls Series), vol. ii. pages xxiv. 289. 175, also 273. 281.

[1626] _Medical Observations and Inquiries_, i. (1757) 12.

Scammony was formerly distinguished by the names _Aleppo_ and _Smyrna_,
the former sort being twice or thrice as costly as the latter; at the
present day Aleppo scammony has quite lost its pre-eminence.

=Localities producing the drug=—Scammony is collected in Asia Minor,
from Brussa and Boli in the north, to Macri and Adalia in the south,
and eastward as far as Angora. But the most productive localities
within this area are the valley of the Mendereh, south of Smyrna:
and the districts of Kirkagach and Demirjik, north of that town. The
neighbourhood of Aleppo likewise affords the drug. A little is obtained
further south in Syria, from the woody hills and valleys about the lake
of Tiberias and Mount Carmel.

=Production=—The scammony plant has a long woody root, which throws off
downwards a few lateral branches, and produces from its knotty summit
numerous twining stems which are persistent and woody at the base. In
plants of three or four years old, the root may be an inch or more in
diameter; in older specimens it sometimes acquires a diameter of three
or four inches. In length, it is from two to three feet, according to
the depth of soil in which it grows. When the root is wounded, there
exudes a milky juice which dries up to a golden-brown, transparent,
gummy-looking substance:—this is _pure scammony_.[1627]

The method followed in collecting scammony for use appears to be
nearly the same in all localities. It has been thus described to us by
two eye-witnesses, both long resident in the East.[1628] Operations
commence by clearing away the bushes among which the plant is commonly
found; the soil around the latter is then removed, so as to leave 4
or 5 inches of the root exposed. This is then cut off in a slanting
direction at 2 to 4 inches below the crown, and a mussel-shell is stuck
into it just beneath the lowest edge, so as to receive the milky-sap
which instantly flows out. The shells are usually left till evening,
when they are collected, and the cut part of the root scraped with
a knife, so as to remove any partially dried drops of juice. These
latter are called by the Smyrna peasants, _kaimak_ or cream, the softer
contents of the shell being called _gala_ or milk.

[1627] Named probably from Σκάυυα, a _trench_ or _pit_, in allusion to
the excavation made around the root.

[1628] The one was the late Mr. S. H. Maltass of Smyrna, whose
interesting paper may be found in _Pharm. Journ._ xiii. (1854) 264; the
other is Mr. Edward T. Rogers, formerly of Caiffa, now (1874) British
Consul at Cairo.

Sometimes the scammony is allowed to dry in the shell, and such must
be regarded as representing the drug in its utmost perfection. But
scammony in shells is not brought into commerce, though a little of it
is reserved by the peasants for their own use.

The contents of the shells and the scraped off drops are next emptied
into a covered copper pot or a leathern bag, carried home, made
homogenous by mixing with a knife, and at once allowed to dry. In this
way a form of scammony is obtained closely approaching that dried in
the shell. But it is a quality of exceptional goodness. Usually the
peasant does not dry off the juice promptly, but allows his daily
gatherings to accumulate; and when he has collected a pound or two, he
places it in the sunshine to soften, and then kneads it, sometimes with
the addition of a little water, into a plastic mass, which he lastly
allows to dry. By this long exposure to heat, and retention in a liquid
state, the scammony juice undergoes fermentation, acquires a strong
cheesy odour and dark colour, and when finally dried, exhibits a more
or less porous or bubbly structure, never observable in shell scammony.

Scammony is very extensively adulterated. The adulteration is often
performed by the peasants, who mix foreign substances into the drug
while it is yet soft; and it is also effected by the dealers, some of
whom purchase it of the peasants in a half-dried state. The substances
used for sophistication are numerous, the commonest and most easily
detected being, according to our experience, carbonate of lime and
flour. Woodashes, earth (not always calcareous), gum arabic, and
tragacanth are also employed; more rarely, wax, yolk of egg, pounded
scammony roots, rosin, or black-lead.

=Description=—The pure juice of the root, simply dried by exposure
to the sun and air, is an amorphous, transparent, brittle substance,
of resinous aspect, a yellowish-brown colour, and glossy fracture.
Scammony possessing these characters is occasionally met with in
the form of flattish irregular masses, about ½ to ¾ of an inch in
thickness, very brittle by reason of internal fissures, yet with but
few air-cavities. In mass, it is of a chesnut-brown, but in small
fragments it is seen to be very pale yellowish-brown and transparent,
with the freshly fractured surface vitreous and shining. When powdered
it is of a very light buff. Rubbed with the moistened finger it forms
a white emulsion. Treated with ether it yields 88 to 90 per cent. of
soluble matter, and a nearly colourless residuum. This scammony, as
well as the pure juice in the shell, is very liable to become mouldy;
but besides this, it throws out, if long kept, a white, mammillated,
crystalline efflorescence, the nature of which we have not been able to
determine. But if scammony is kept quite dry, neither mouldiness nor
efflorescence makes its appearance.

The ordinary fine scammony of commerce, known as _Virgin Scammony_, is
also in large flat pieces or irregular flattened lumps and fragments,
which in mass have a dark grey or blackish hue. Viewed in thin
fragments, it is seen to be translucent and of a yellowish-brown. It
is very easily broken, exhibits a shining fracture, gives an ashy-grey
powder, and has a peculiar cheesy odour. Some of the pieces have a
porous, bubbly structure, indicative of fermentation; the more solid
often show the efflorescence already mentioned. Scammony has not much
taste, but leaves an acrid sensation in the throat.

=Chemical Composition=—Scammony owes its active properties as a
medicine to a resin shown (1860) by Spirgatis to be identical with
that found in the root of the Mexican _Ipomœa orizabensis_, known in
commerce as _Male Jalap_: this resin called _Jalapin_ will be described
in the next article. The other constituents of pure scammony are not
well known. One of them is the substance which, as already stated,
makes its appearance as small masses of cauliflower crystals on the
surface of pure scammony, when the latter is kept in air not perfectly
dry.

Whether the odour observable in commercial scammony is due to a
volatile fatty acid developed by fermentation, is a question still to
be investigated.

=Commerce=—The export of scammony from Smyrna amounted in 1871 to 278
cases, valued at £8320; in 1872 to 185 cases, value £6100. According
to a report of Consul Skene on the trade of Northern Syria,[1629]
737 cases of scammony were exported from the province of Aleppo in
1872,—six-sevenths of the quantity being for England. In 1873 Aleppo
exported by way of Alexandretta to England 46,500 kilogrammes of
scammony root and 900 kilogrammes of the resin, the latter being valued
at 36,000 francs (£1444).

An establishment at Brussa, founded by Della Sudda, of Constantinople,
is stated to export since 1870 a very good scammony resin extracted by
alcohol.[1630]

=Uses=—Employed as an active cathartic, often in combination with
colocynth and calomel.

=Adulteration=—Scammony is very often imported in an adulterated
state, but the adulteration is so clumsily effected, and is so easily
discoverable by simple tests, or even by ocular examination, that
druggists have but little excuse for accepting a bad article.

[1629] Presented to Parliament, July 1873.

[1630] Dragendorff’s _Jahresbericht_, 1876. 158.

We have already named the substances used in the sophistication of
scammony: of these, the most frequent are carbonate of lime and
farinaceous matter. The first may generally be recognized by examining
the fractured surface of the drug with a good lens, when the white
particles of the carbonate will be perceived. If the surface is then
touched (while still _sub lente_) with hydrochloric acid, effervescence
will prove the presence of a carbonate. Other earthly adulterants can
be discovered by incineration, or by examining the residue of the
drug after treatment with ether. Starchy substances, the presence of
which may be surmised by the scammony being difficult to break, are
detectable by the microscope or by solution of iodine, a cold decoction
of scammony not being affected by that reagent. Scammony that is
ponderous, dull and clayey, not easily broken in the fingers, or which
when broken does not exhibit a clean, glossy surface, or which does
not afford at least 80 per cent. of matter soluble in ether, should be
rejected. That which is made up in the form of hard, dark, circular
cakes is widely different from pure scammony.

Scammony may be distinguished from _Resin of Scammony_ by its property
of forming an emulsion when wetted. The resin is also more glossy and
almost entirely soluble in ether.

Radix Scammoniæ.

The frauds commonly practised on the scammony of commerce have given
rise to various schemes for obtaining the drug in a purer form, as well
as at a more moderate price.[1631]

So far back as 1839, the Edinburgh College prescribed a _Resina
Scammonii_, which was prepared by exhausting scammony with a spirit of
wine, distilling off the spirit, and washing the residue with water.
Such an extract was manufactured by the late Mr. Maltass of Smyrna, and
occasionally shipped to London.

In consequence of a suggestion made by Mr. Clark, manufacturer of
liquorice at Sochia near Scala Nuova, south of Smyrna, a patent was
taken out (1856) by Prof. A. W. Williamson of London, for preparing
this resin directly from the dried root by means of alcohol. The same
chemist shortly afterwards devised an improved process, which consists
in boiling the roots first with water and then with dilute acid, so
as to deprive them of all matters soluble in those menstrua, and
afterwards extracting the resin by alcohol.

Resin of Scammony, obtained either from scammony or from the dried
root, is ordered in the _British Pharmacopœia_ of 1867, and is
manufactured by a few houses. It is a brown, translucent, brittle
substance of resinous fracture, entirely soluble in ether, and not
forming an emulsion when wetted with water.

Scammony root is occasionally brought into the London market, sometimes
in rather large quantity,[1632] but it is not generally kept by
druggists, nor do we find it quoted in price-currents. Its collection
is even opposed in some parts of Turkey by the local authorities.[1633]

[1631] Scammony was quoted in a London price current, April 1874, at
8_s._ to 36_s._ per lb., Resin of Scammony at 14_s._ per lb.

[1632] Thus 100 bales were offered in a drug sale, 3 July 1873.

[1633] Such was the case at Aleppo, as we know by a private letter from
Mr. Consul Skene.—D. H.

The root consists of stout, woody, cylindrical pieces, often spirally
twisted, 2 to 3 inches in diameter, covered with a rough, furrowed,
greyish-brown bark. They are internally pale brown, tough and resinous,
with a faint odour and taste resembling jalap. A good sample yielded us
5½ per cent. of resin; Kingzett and Farries (1877) showed the root to
be devoid of an alkaloid.


RADIX JALAPÆ.

_Tuber Jalapæ_; _Jalap_, _Vera Cruz Jalap_; F. _Racine de Jalap_; G.
_Jalape_.

=Botanical Origin=—_Ipomœa Purga_ Hayne (_Convolvulus Purga_ Wenderoth,
_Exogonium Purga_ Bentham), a tuberous-rooted plant, throwing out
herbaceous, twining stems, clothed with cordate-acuminate sharply
auricled leaves, and bearing elegant salver-shaped, deep pink flowers.
It grows naturally on the eastern declivities of the Mexican Andes,
at an elevation above the sea of 5000 to 8000 feet, especially about
Chiconquiaco and the adjacent villages, and also around San Salvador
on the eastern slope of the Cofre de Perote. In these localities where
rain falls almost daily, and where the diurnal temperature varies
from 15° to 24° C. (60° to 75° F.), the plant occurs in shady woods,
flourishing in a deep rich vegetable soil.

The jalap grows freely in the south of England, if planted in a
sheltered border, but its flowers are produced so late in autumn that
they rarely expand, and the tubers, which develope in some abundance,
are liable to be destroyed in winter unless protected from frost.

The plant has been introduced on the Neilgherry Hills in the south
of India; it succeeds there remarkably well,[1634] and might be
extensively propagated if there were any adequate inducement.

=History=—The use as a purgative of the tuber of a convolvulaceous
plant of Mexico, was made known by the early Spanish voyagers; and so
highly was the new drug esteemed that large quantities of it reached
Europe during the 16th century.

Monardes, writing in 1565, says the new drug was called _Ruybarbo de
las Indias_ or _Ruybarbo de Mechoacan_, the latter name being given
in allusion to the province of Michoacan whence the supplies were
derived. Some writers have advanced the opinion that mechoacan root was
the modern jalap, but in this we do not concur, for the description
given of mechoacan and the place of its production do not apply well
to jalap. Both drugs were moreover well known about 1610; they were
perfectly distinguished by Colin, an apothecary of Lyons (1619),
who mentions jalap (“_racine de Ialap_”) as then newly brought to
France.[1635] They were however often confounded, or at least only
distinguished by their difference of tint. Thus jalap, which at that
period used to be imported cut into transverse slices,[1636] was
termed, from its darker colour, _Black Mechoacan_; and on the other
hand, the paler mechoacan was in later times known as _White Jalap_.

[1634] Thus at Ootacamund, Mr. Broughton, in a letter to one of us (15
January 1870), speaks of receiving “a cluster of tubers” weighing over
9 lb., and remarks that the plant grows as easily as yam.

[1635] Monardes, _Hist. des Medicamens_, trad. par Colin, ed. 2.
16.—The first edition of this work seems to be unknown.

[1636] Hill, _History of the Mat. Med._ Lond. 1751. 549.

Mechoacan root is now known to consist (at least in part) of the large
thick tuber of _Ipomœa Jalapa_ Pursh (_Batatas Jalapa_ Choisy), a plant
of the Southern United States and Mexico. As a drug it has been long
obsolete in Europe, having given place to jalap, which is a more active
and efficient purgative.

The botanical source of jalap was not definitely ascertained until
about the year 1829, when Dr. Coxe of Philadelphia published a
description and coloured figure, taken from living plants sent to him
two years previously from Mexico.[1637]

=Manner of Growth=—Though we have cultivated the jalap plant for many
years, we have had no opportunity of examining the seedling, but
judging from analogy suppose that it has at first a small tap-root
which gradually thickens after the manner of a radish. A root of
jalap, called by some _tuber_ and by others _tubercule_, throws out in
addition to aerial stems, slender, prostrate, underground shoots which
emit roots at intervals. These roots while but an inch or two long
become thickened and carrot-shaped, gradually enlarging into napiform
tuber-like bodies, which emit a few rootlets from their surface and
taper off below in long, slender ramifications. The thickened roots
have no trace of leaf-organs; the aerial stems grow from the shoot from
which they originated.

Fresh jalap roots (tubers) are externally rough and dark brown,
internally white and fleshy.

=Collection=—Jalap is said to be dug up in Mexico during the whole
year.[1638] The smaller roots are dried entire; the larger are cut
transversely, or are gashed so that they may dry more easily. As drying
by sun-heat would be almost impracticable owing to the wetness of the
climate, the roots are placed in a net, and suspended over the almost
constantly burning hearth of the Indian’s hut, where they gradually
dry, and at the same time often contract a smoky smell. Much of the
jalap that has of late arrived has been more freely sliced than usual,
and has obviously been dried with less difficulty.

According to Schiede, whose account was written in 1829,[1639] the
Indians of Chiconquiaco were at that period commencing the cultivation
of jalap in their gardens.

=Description=—The jalap of commerce consists of irregular, ovoid
roots, varying from the size of an egg to that of a hazel-nut, but
occasionally as large as a man’s fist. They are usually pointed at the
lower end, deeply wrinkled, contorted and furrowed, and of a dark brown
hue, dotted over with numerous little, elongated, lighter coloured
scars, running transversely. The large roots are incised lengthwise, or
cut into halves or quarters, but the smaller are usually entire. Some
of the small roots are spindle-shaped or cylindrical; others can be
found which are nearly globular, smooth and pitchy-looking, but these
latter are seldom solid. Good jalap is ponderous, tough, hard and often
horny, becoming brittle when long kept, and breaking with a resinous
non-fibrous fracture; internally it is of a pale dingy brown or dirty
white. It has a faint smoky, rather coffee-like odour, and a mawkish
taste, followed by acridity.

[1637] _American Journal of Med. Sciences_, v. (1829) 300. pl. 1-2.

[1638] It is plain that such a proceeding is irrational. The roots
should be dug up when the aerial stems have died down.

[1639] _Linnæa_, iii. (1830) 473; _Pharm. Journ._ viii. (1867) 652.—We
are not aware of any more recent account.

=Microscopic Structure=—Seen in transverse section, jalap exhibits no
radiate structure, but numerous small concentric rings, which in many
pieces are very regularly arranged. They are due to the laticiferous
cells, differing from the surrounding parenchyme only by their contents
and rather large size. These laticiferous cells traverse the tissue in
a vertical direction, constituting vertical bands, as may be observed
on a longitudinal section; the single cells are simply placed one
on the other, and do not form elongated ducts as in _Lactuca_ or
_Taraxacum_.

The fibro-vascular bundles of jalap are neither numerous nor large;
they are accompanied by thin-walled cells, so that firm woody rays do
not occur. Parenchymatous cells are abundant, and, on a longitudinal
fracture especially, if subsequently moistened, are seen to constitute
concentric layers. The laticiferous cells are always found in the outer
part of each layer. The suberous coat with which the drug is covered is
made up of the usual tabular cells.

The parenchyme of jalap is loaded with starch grains; in the pieces
which have been submitted to heat in order to dry them, the starch
appears as an amorphous mass, and the drug then exhibits a horny
consistence and greyish fracture, instead of being mealy. Crystals of
calcium oxalate are frequently met with. The laticiferous cells contain
the resin of jalap in a semi-fluid state, even in the dry drug; drops
of the resinous emulsion flow out of the cells, if thin slices are
moistened by any watery liquid.

=Chemical Composition=—Jalap owes its medicinal efficacy to a resin,
which is extractable by exhausting the drug with spirit of wine,
concentrating the alcoholic solution to a small bulk, and pouring
it into water. The resin precipitated in this manner is then washed
and dried; it is contained in jalap to the extent of 12 to 18 per
cent.[1640]

From this crude resin, which is the _Resina jalapæ_ of the
pharmacopœias, ether or chloroform extracts 5 to 7 (12, Umney) per
cent. of a resin which, according to Kayser,[1641] partially solidifies
when in contact with water in crystalline needles. We can by no means
confirm Kayser’s statement. The residue (insoluble in ether) is one
of the substances to which the name _Jalapin_ has been applied.[1642]
W. Mayer, 1852-1855, who designated it _Convolvulin_,[1643] found it
to have the composition C₃₁H₅₀O₁₆. When purified, it is colourless;
it dissolves easily in ammonia as well as in the fixed alkalis, and
is not re-precipitated by acids, having been converted by assumption
of water into amorphous Convolvulic Acid, which is readily soluble in
water. Both convolvulin and _convolvulic acid_ are resolved by moderate
heating with dilute acids, or with emulsin, into crystallizable
_Convolvulinol_, C₂₆H₅₀O₇, and sugar. Convolvulinol in contact with
aqueous alkalis is converted into _Convolvulinolic Acid_, C₂₆H₄₈O₆,
which is slightly soluble in water and crystallizable.

[1640] Guibourt obtained of it 17 per cent., Umney 21·5, Squibb 11 to
16, T. and H. Smith “not more than 15,” D. Hanbury 11 to 15·8. Jalap
grown in Bonn afforded to Marquart 12 per cent.; a root cultivated at
Münich gave Widnmann 22 per cent.; from plants produced in Dublin W. G.
Smith got 9 to 12 per cent.; and fine tubers from Ootacamund in India
yielded to one of us 18 per cent. of resin. Broughton is of opinion
that exposure of the sliced tuber to the air in the process of drying,
favours the formation of resin, by the oxidation of a hydrocarbon.

[1641] Gmelin, _Chemistry_, xvi. (1864) 159.

[1642] As by Pereira, _Elem. of Mat. Med._ ii. (1850) 1463.

[1643] Gmelin, _op. cit._ xvi. 154.

When convolvulin or its derivatives is treated with nitric acid, it
yields several acids, one of which is the _Sebacic Acid_,

    C₈H₁₆ {COOH
          {COOH

which is to be obtained by treating castor oil or other fatty
substances in the same manner. Sebacic acid forms crystalline scales,
soluble in boiling water, melting at 128°. That from jalap was first
thought to be a peculiar acid, and therefore termed _ipomic_ or
_ipomœic acid_. Its identification is due to Neison and Bayne (1874).

Convolvulin (dry) melts at 150° C., but a small amount of water renders
it fusible below 100° C. It is insoluble in oil of turpentine and in
ammonia. It dissolves in dilute nitric acid without becoming coloured
or evolving gas. Convolvulin possesses in a high degree the purgative
property of jalap, but this is not the case with convolvulinol.

The other constituents of jalap include starch, uncrystallizable sugar,
gum, and colouring matter. The sugar, according to Guibourt, exists to
the extent of 19 per cent.

=Commerce=—We have no means of knowing to what extent jalap is produced
in Mexico. The imports of the drug into the United Kingdom amounted in
1870 to 169,951 lb. Very considerable quantities have of late (1873)
appeared in the London drug-sales.

=Uses=—Jalap is employed as a brisk cathartic.


Other kinds of Jalap.

Besides true jalap, the roots of certain other _Convolvulaceæ_ of
Mexico have been employed in Europe, either in the form of jalapin, or
as adulterants of the more costly, legitimate drug. The two following
have been extensively imported and have been traced to their botanical
source; but there are others, of more occasional occurrence, the origin
of which has not been ascertained.[1644]

1. _Light_, _Fusiform_, or _Woody Jalap_, _Male Jalap_, _Orizaba Root_,
_Jalap Tops_ or _Stalks_, _Purgo macho_ of the Mexicans.

This drug is derived from _Ipomœa orizabensis_ Ledanois,[1645] a
plant of Orizaba, which is but imperfectly known. It is described as
a pubescent climber, having a spindle-shaped root about two feet long
of woody and fibrous texture. The drug occurs in irregular rectangular
or block-like pieces, evidently portions of a very large root,
divided transversely and longitudinally. Sometimes it is more like
true jalap, being in entire roots, of smaller size, spindle-shaped,
not spherical. It has a somewhat lighter colour than jalap, and much
deeper longitudinal wrinkles. The larger pieces often exhibit deep
cuts from an axe or knife; transverse slices are of rare occurrence.
Although generally less ponderous than jalap, the Orizaba drug is
nevertheless of a compact and often horny texture. From jalap it is
easily distinguished by its radiated transverse section, and the
numerous thick bundles of vessels which project as woody fibres from
the fractured surface.

[1644] For information about some of these, consult Guibourt, _Histoire
des Drogues_, ii. (1869) 523.

[1645] _Journ. de Chimie méd._ x. (1834) 1-22. pl. 1. 2. (with
unsatisfactory figures).

In chemical constitution Orizaba root is closely parallel to jalap.
The resin was named by Mayer _Jalapin_; it is the _Jalapin_ of
Gmelin’s _Chemistry_ (xvi. 405), and perhaps the jalapin of English
pharmacy.[1646]

In the pure state it is a colourless amorphous translucent resin,
_dissolving perfectly in ether_,[1647] thus differing from convolvulin
the corresponding resin of jalap. We find that it is readily soluble
also in acetone, amylic alcohol, benzol and phenol, not in bisulphide
of carbon. It has the composition of C₃₄H₅₆O₁₆, so that it is
homologous with convolvulin; the decomposition-products of jalapin
obtained by similar treatment, namely jalapic acid, jalapinol, and
jalapinolic acid, are likewise homologous with the corresponding
substances obtained from convolvulin. All these bodies when treated
with nitric acid yield ipomœic acid. Jalapin has the same fusing point
as convolvulin, and behaves in the same manner with alkalis.

The root afforded us 11·8 per cent. of resin dried at 100° C. When
perfectly washed, decolorized and dissolved in two parts of alcohol,
this resin turned the plane of polarization of a ray of light 9·8°
to the left, in a column of 50 mm. long. Convolvulin under the same
conditions turned it only 5·8°. The resin of Orizaba root is held by
chemists to be identical with that of scammony, of which it has the
drastic action.

2. _Tampico Jalap_,—_Purga de Sierra Gorda_ of the Mexicans. The plant
which affords this drug has been described by one of us (1869) under
the name of _Ipomœa simulans_.[1648] It is closely related to _I.
Purga_ Hayne, from which by its foliage it cannot be distinguished,
but it has a _bell-shaped corolla_ and _pendulous flower-buds_, which
are very different. _I. simulans_ Hanbury grows in Mexico along the
mountain range of the Sierra Gorda in the neighbourhood of San Luis de
la Paz, from which town and the adjacent villages its roots are carried
down to Tampico. It has also been found on the lofty Cordillera near
Oaxaca, but whether there collected we know not.

The drug, to which in trade the name _Tampico Jalap_ is commonly
applied, has been imported during the last few years in considerable
quantities. In appearance it closely approaches true jalap, but the
roots are generally smaller, more elongated or finger-like, more
shrivelled and corky-looking, wanting in the little transverse scars
that are plentifully scattered over the roots of true jalap. Many
pieces occur however which it is impossible to distinguish by the eye
from true jalap, with which it agrees also in odour and taste.

Tampico jalap yielded to one of us 10 per cent. of _purified_ resin,
entirely soluble in ether. Umney[1649] obtained 12 to 15 per cent. of
resin almost wholly soluble in ether; Evans got 13 per cent., but found
only about half of this to be soluble in ether.[1650] According to
Andouard[1651] the resin of Tampico jalap is not deficient in purgative
powers.

[1646] The name is ill-chosen and misleading, but having been adopted
in standard works, it might occasion greater confusion to attempt to
supersede it, and its several derivatives.

[1647] It is at least a fact, that of numerous samples of jalapin that
we have examined (1871), every one is _completely soluble in ether_.

[1648] Hanbury, On a species of _Ipomœa_, affording Tampico Jalap,
_Journ. of Linn. Soc._, Bot. xi. (1871) 279, tab. 2; _Pharm. Journ._
xi. (1870) 848; _American Journ. of Pharm_., xviii. (1870) 330;
_Science Papers_, 1876. 349.

[1649] _Pharm. Journ._ ix. (1868) 282.

[1650] _Ibid._ ix. (1868) 330.

[1651] _Etude sur les Convolvulacées purgatives_ (thèse) Paris, 1864.
31.


SEMEN KALADANÆ.

_Semen Pharbitidis_; _Kaladana_.

=Botanical Origin=—_Ipomœa Nil_[1652] Roth (_Pharbitis Nil_ Choisy,
_Convolvulus Nil_ L.), a twining annual plant, with a large blue
corolla, much resembling the Major Convolvulus (_Pharbitis hispida_
Choisy) of English gardens, but having three-lobed leaves.[1653] It
is found throughout the tropical regions of both hemispheres, and is
common in India, ascending the mountains to a height of 5000 feet.

=History=—The seeds of this plant were employed in medicine by the
Arabian physicians under the name _Habbun-nil_; and they have probably
been long in use among the natives of Hindustan. In recent times
they have been recommended by O’Shaughnessy, Kirkpatrick, Bidie,
Waring[1654] and many other European practitioners in India as a safe
and efficient cathartic.

=Description=—The shape of the seeds is that which would result if a
nearly spherical body were divided perpendicularly around its axis into
6 or 8 almost equal segments, only that the back is less regularly
vaulted. The seeds are ¼ of an inch high and nearly as much broad; 100
of them weigh on an average about 6 grammes. There is a smaller variety
imported from Calcutta, of which 100 seeds weigh but little over 3
grammes; in every other respect the two sorts are identical. Both
are of a dull black, excepting at the umbilicus, which is brown and
somewhat hairy. The adjacent parts of the thin shell (testa) crack in
various directions, if the seed is kept for a short time in cold water.
If it is removed from the upper part of the vaulted back, the radicle
becomes visible, surrounded by the undulated folds of the cotyledons,
which join perpendicularly, but cannot be easily unfolded by reason
of the thin seminal integument. Cut transversely, the cotyledons show
the same curled structure. Throughout their tissue, small bright
glands in considerable number are observable, even without a lens. The
kernel, which is devoid of albumen, has at first a nutty taste, with
subsequently a disagreeable persistent acridity. When bruised in a
mortar, the seeds evolve a heavy earthy smell.

=Microscopic Structure=—The seed is covered with a dark blackish
cuticle, formed of a densely packed tissue, the cells of which show
zigzag outlines. The dark brown epidermis is composed of very close
cylindrical cells, about 70 mkm. in length and 5 to 7 mkm. in diameter;
they require to be treated with chromic acid in order that their
structure may be distinctly seen.

The tissue of the kernels is made up of thick-walled cells. Between
this tissue and the shell there is a colourless layer, about 70 mkm.
thick, of thin-walled corky parenchyme. The cotyledons contain in
their narrow tissue numerous granules of albuminous matter, mucilage,
a little tannic acid, crystals of oxalate of calcium, and a few starch
granules. The glands or hollows, before alluded to as occurring
throughout the tissue of the cotyledons, are about 70 mkm. in diameter,
and contain an oily liquid.

[1652] In Hindustani _Nil_ signifies _blue_, and _Kaladana_, black seed.

[1653] Fig. in Bentley and Trimen, _Med. Plants_, part 22 (1877).

[1654] _Pharm. Journ._ vii. (1866) 496.

=Chemical Composition=—By exhausting the seeds dried at 100° C. with
boiling ether, we obtained a thick light brownish oil having an acrid
taste and concreting below 18° C. The powdered seeds yielded of this
oil 14·4 per cent. Water removes from the seeds a considerable amount
of mucilage, some albuminous matter and a little tannic acid. The
first is soluble to some extent in dilute spirit of wine, and may be
precipitated therefrom by an alcoholic solution of acetate of lead.

The active principle of kaladana is a _resin_, soluble in alcohol, but
neither in benzol nor in ether. From the residue of the seeds after
exhaustion by ether, treatment with absolute alcohol removed a pale
yellowish resin in quantity equivalent to 8·2 per cent. of the seed.

Kaladana resin, which has been introduced into medical practice in
India under the name of _Pharbitisin_,[1655] has a nauseous acrid taste
and an unpleasant odour, especially when heated. It melts about 160° C.
The following liquids dissolve it more or less freely, namely, spirit
of wine, absolute alcohol, acetic acid, glacial acetic acid, acetone,
acetic ether, methylic and amylic alcohol, and alkaline solutions.
It is on the other hand insoluble in ether, benzol, chloroform, and
sulphide of carbon. With concentrated sulphuric acid, it forms a
brownish yellow solution, quickly assuming a violet hue. This reaction
however requires a very small quantity of the powdered resin. If a
solution of the resin in ammonia, after having been kept a short time,
is acidulated, no precipitate is formed; but the solution is now
capable of separating protoxide of copper from an alkaline solution of
the tartrate, which originally it did not alter. Heated with nitric
acid, the resin affords _sebacic acid_ (see p. 446).

From these reactions of kaladana resin, we are entitled to infer that
it agrees with the resin of jalap or _Convolvulin_. To prepare it in
quantity, it would probably be best to treat the seeds with common
acetic acid, and to precipitate it by neutralizing the solution. We
have ascertained that the resin is not decomposed when digested with
glacial acetic acid at 100° C., even for a week.

We have had the opportunity of examining a sample of kaladana resin
manufactured by Messrs. Rogers and Co., chemists of Bombay and Poona,
which we found to agree with that prepared by ourselves. It is a light
yellowish friable mass, resembling purified jalap resin, and like
it, capable of being perfectly decolorized by treatment with animal
charcoal.

=Uses=—Kaladana seeds have cathartic powers like jalap. Besides the
resin, an extract, tincture and compound powder have been introduced
into the _Pharmacopœia of India_. In many parts of India the natives
take the roasted seeds as a purgative.

[1655] _Pharmacopœia of India_, 1868, 156.




SOLANACEÆ.


STIPES DULCAMARÆ.

_Caules Dulcamaræ_; _Bitter-sweet_, _Dulcamara_, _Woody Nightshade_; F.
_Douce-amère_, _Morelle grimpante_; G. _Bittersüss_.

=Botanical Origin=—_Solanum Dulcamara_ L., a perennial shrubby plant,
having small purple flowers and red berries, occurring throughout
Europe, except in the extreme north. It is also found in Northern
Africa, and in Asia Minor, and has become naturalized in North America.
It is common in moist, shady hedges and thickets.[1656]

=History=—Bitter nightshade, “manyglog,” was an ingredient, together
with wild sage and betony, of a drink which the Welsh “Physicians of
Myddfai” in the 13th century prepared for the bite of a mad dog.[1657]
The stalks of bitter-sweet were also used in the medical practice by
the German physicians and botanists of the 16th century, one of whom,
Tragus (1552), has figured and described it, under the name of _Dulcis
amara_ or _Dulcamarum_.

[1656] _Solanum nigrum_ L. which slightly resembles dulcamara, is a
low-growing annual or biennial, with _herbaceous_ stems, and berries
usually _black_.

[1657] _Meddygon Myddvai_ (see Appendix) 185. 293. 375.

=Description=—The older stems are woody; the upper and younger are
soft and green, long and straggling, attaining by the support of other
plants a height of 6 feet or more, and dying back in the winter. For
medicinal use, the shoots of a year or two old should be gathered,
either late in the year, or early in the spring before the leaves
come out. These shoots are several feet long, by about ⅕ of an inch
thick, of a light greenish-brown, sometimes cylindrical, at others
indistinctly 4-or 5-sided, slightly furrowed longitudinally, or
somewhat warty.

The thin, shining cork-bark easily exfoliates, showing beneath it the
mesophlœum which is rich in chlorophyll. The stalks are mostly hollow,
and partially filled with a whitish pith. The wood when dried is
about half or one-third as broad as the hollow centre, and the green
bark considerably narrower than the wood; the latter has a radiate
structure, and in older stems exhibits two or three sharply-defined
annual rings. The stems are usually cut into short lengths before being
dried for use.

The odour, which is rather fœtid and unpleasant, is to a great
extent dissipated by drying. The taste, at first slightly bitter, is
afterwards sweetish. The bitter appears to be more predominant in the
spring than in the autumn.

=Microscopic Structure=—The epidermis of younger shoots consists of
tabular thick-walled cells, many of them being elevated from the
surface as short blunt hairs. The older stems are covered with the
usual suberous envelope. The boundary between the mesophlœum and the
endophlœum is marked by a ring of strong liber-fibres, some of which
also occur in the pith. The woody part is rich in large vessels. In the
parenchymatous tissue of bitter-sweet, small crystals of oxalate of
calcium, not of a well-defined outline, and minute starch granules are
deposited.

=Chemical Composition=—The taste of bitter-sweet appears due,
according to Schoonbroodt (1867), to a bitter principle yielding by
decomposition, sugar and _Solanine_,—the latter in very small amount.
Solanine is an alkaloid; it was first prepared in 1820 by Desfosses, a
pharmacien at Besançon, from the berries of _Solanum nigrum_ L., and
was subsequently detected by the same chemist in the leaves and stalks
of _S. Dulcamara_, and by Peschier in the berries. Winckler (1841)
observed that the alkaloid of dulcamara stems can be obtained only
in an amorphous state, and that it behaves to platinic and mercuric
chlorides differently from the solanine of potatoes. Moitessier (1856)
confirmed this observation, and obtained only amorphous salts of the
solanine of bitter-sweet.

Zwenger and Kind on the one hand, and O. Gmelin on the other (1859
and 1858), found that solanine, C₄₃H₆₉NO₁₆ (or C₄₂H₈₇NO₁₅, according
to Hilger, 1879), is a conjugated compound of sugar and a peculiar
crystallizable alkaloid, _Solanidine_, C₂₆H₃₉NO (or C₂₆H₄₁NO₂?). The
latter, under the influence of strong hydrochloric acid, gives up
water, and is converted into the amorphous and likewise basic compound,
_Solanicine_.

Wittstein (1852) stated another alkaloid, dulcamarine, to be present
in the stems of bitter-sweet. But Geissler (1875) proved that this
substance, when perfectly pure, contains no nitrogen, and is not an
alkaloid. Geissler obtained his _Dulcamarin_ by warming an aqueous
decoction of the drug with charcoal, which he dried and exhausted with
boiling alcohol. This on evaporation afforded a yellowish amorphous
matter, which was dissolved in water and mixed with a very little
ammonia; a substance containing nitrogen then separated. The liquid was
evaporated, the residue again dissolved in alcohol, and the alcohol
distilled. Dulcamarin thus obtained is a yellowish powder of at first
bitter and subsequently permanently sweet taste. It dissolves in water
or alcohol, not in ether, chloroform, bisulphide of carbon. By boiling
dulcamarin with dilute acids it splits up according to the following
equation:—

    C₂₂H₃₄O₁₀ + 2 OH₂ = C₆H₁₂O₆ · C₁₆H₂₆O₆.
    Dulcamarin.        Sugar.   Dulcamaretin.

Dulcamaretin, a dark brown, tasteless mass, is soluble in alcohol, not
in water or ether.

=Uses=—Dulcamara is occasionally given in the form of decoction, in
rheumatic or cutaneous affections; but its real action, according to
Garrod, is unknown. This physician remarks[1658] that it does not
dilate the pupil or produce dryness of the throat like belladonna,
henbane or stramonium. He has given to a patient 3 pints of the
decoction _per diem_ without any marked action, and has also
administered as much as half a pound of the fresh berries with no ill
effect.

[1658] _Essentials of Materia Medica_, 1855. 196.


FRUCTUS CAPSICI.

    _Pod Pepper_, _Red Pepper_, _Guinea
        Pepper_, _Chillies_, _Capsicum_; F.
        _Piment ou Corail des Jardins_, _Poivre
        d’Inde ou de Guinée_; G. _Spanischer
        Pfeffer_.

=Botanical Origin=—The plants, the fruits of which are known as
_Pod Pepper_, have for a long period been cultivated in tropical
countries, and are now found in such numerous varieties that an exact
determination of the original species is a point of great difficulty.
Of several species having pungent fruits, the two following are those
which supply the spice found in British commerce:—

1. _Capsicum fastigiatum_ Blume,[1659] a small ramous shrub, with
4-sided, fastigiate, diverging branches; fruit-bearing peduncles
sub-geminate, slender, erect; fruit very small, subcylindrical, oblong,
straight, with calyx obconical and truncate. It occurs apparently wild
in Southern India, and is extensively cultivated in Tropical Africa and
America.

Roxburgh, who describes this plant under the name _C. minimum_, terms
it _East Indian Bird Chilly_ or _Cayenne Pepper Capsicum_. Wight says
that it is consumed by the natives of India, but that it is not the
sort preferred. It is this species that the authors of the British
Pharmacopœia have cited as the source of the _Fructus Capsici_ to be
used in medicine, and it certainly furnishes the greater part of the
Pod Pepper now found in the London market.

2. _C. annuum_ L., an herbaceous (sometimes shrubby?) plant, with fruit
extremely variable in size, form, and colour, in some varieties erect,
in others pendulous. According to Naudin, in whose opinion we concur,
_C. longum_ DC.[1660] and _C. grossum_ Willd. are not specifically
distinct from this plant. It furnishes the larger kinds of Pod Pepper
and, as we believe, much of the Cayenne Pepper which is imported in the
state of powder.

=History=—All species of _Capsicum_ appear to be of American origin;
no ancient Sanskrit or Chinese name for the genus is known, and the
Latin and Greek names that have been referred to it are extremely
doubtful.[1661]

The earliest reference to the fruit as a condiment that we have met
with, occurs in a letter written in 1494 to the Chapter of Seville by
Chanca, physician to the fleet of Columbus in his second voyage to the
West Indies. The writer in noticing the productions of Hispaniola,
remarks that the natives live on a root called _Age_, which they season
with a spice they term _Agi_, also eaten with fish and meat.[1662] The
first of these words signifies _yam_, the second is the designation
of Red Pepper, and still the common name for it in Spanish. Capsicum
and its uses are more particularly described by Fernandez, who reached
Tropical America from Spain in A.D. 1514.[1663]

[1659] Wight, _Icones Plant. Indiæ Orient._ iv. (1850) tab. 1617;
_Capsicum minimum_ Roxb. _Flor. Ind._ i. (1832) 574. Faire has
ascertained that this is the _Capsicum frutescens_ of the _Species
Plantarum_ of Linnæus, but not that of the _Hortus Cliffortianus_ of
the same botanist, to which latter the name _C. frutescens_ is usually
applied.

[1660] The chief distinction between _C. annuum_ and _C. longum_ is
that the former has an _erect_, the latter a _pendulous_ fruit.

[1661] Dunal in De Cand. _Prodromus_, xiii. i. 412.

[1662] _Letters of Christopher Columbus_, translated by Major (Hakluyt
Society), 1870. 68.

[1663] _Historia de las Indias_, Madrid, i. (1851) 275.

In the _Historia Stirpium_ of Leonhard Fuchs, published at Basle
in 1542, fol. 733, may be found the first and excellent figures of
_Capsicum longum_ DC. under the name of _Siliquastrum_ or _Calicut
Pepper_; the author states that the plant has been introduced into
Germany from India a few years previously. From this might be inferred
an Indian origin; but on the other hand, Clusius asserts that the
plant was brought from Pernambuco by the Portuguese, whose commercial
intercourse with India would easily explain it being carried thither at
an early period. He further states, that the American capsicum had been
generally introduced into the gardens at Castille, and that it was used
all the year round, green or dried, as a condiment and as pepper. He
also saw it cultivated in abundance at Brünn in Moravia in 1585.[1664]

[1664] Caroli Clusii _Curæ posteriores_, Antverp., 1611. 95.

_Capsicum longum_ DC. was grown in England by Gerarde (1597 _et
antea_), who speaks of the pods as well known, and sold “in the shops
at Billingsgate by the name of Ginnie Pepper.”

=Description=—As already indicated, the Pod Pepper of commerce is of
two kinds, namely:—

1. Fruits of _Capsicum fastigiatum_—These are ½ to ¾ of an inch
in length, by about ²/₁₀ of an inch in diameter, of an elongated,
subconical form, tapering to a blunt point, and slightly contracted
towards the base. The calyx, which is not always present, is
cup-shaped, 5-toothed, 5-sided, supported on a slender, straight
pedicel, ¾ to 1 inch long. The fruits, which are somewhat compressed
and shrivelled by drying, and also brittle when old, have a leathery,
smooth, shining translucent, thin, dry pericarp, of a dull orange-red,
enclosing about 18 seeds, attached in two cells to a thin central
partition. The seeds have the form of roundish or ovate discs, about
⅛ of an inch in diameter, somewhat thickened at the edges; the embryo
is curved, almost into a ring. The taste of the pericarp, and likewise
of the seeds, is extremely pungent and fiery. The dried fruit has an
odour by no means feeble, which we cannot compare to that of any other
substance.

2. Fruits of _Capsicum annuum_ of the commonest variety resemble those
of _C. fastigiatum_, except that they are of longer size, being from 2
to 3 or more inches in length, often rather more tapering towards the
extremity. The seeds scarcely surpass in size those of _C. fastigiatum_.

=Microscopic Structure=—The pericarp consists of two layers, the outer
being composed of yellow thick-walled cells. The inner layer is twice
as broad and exhibits a soft shrunken parenchyme, traversed by thin
fibro-vascular bundles. The cells of the outer layer especially are
the seat of the fine granular colouring matter. If it is removed by
an alcoholic solution of potash, a cell-nucleus and drops of fat oil
make their appearance. The structural details of this fruit afford
interesting subjects for microscopical investigation.

=Chemical Composition=—Bucholz in 1816, and about the same time
Braconnot, traced the acridity of capsicum to a substance called
_Capsicin_. It is obtained by treating the alcoholic extract of ether,
and is a thick yellowish-red liquid, but slightly soluble in water.
When gently heated, it becomes very fluid, and at a higher temperature
is dissipated in fumes which are extremely irritating to respiration.
It is evidently a mixed substance, consisting of resinous and fatty
matters.

Felletár in 1869 exhausted capsicum fruits with dilute sulphuric acid,
and distilled the decoction with potash. The distillate, which was
strongly alkaline and smelt like conine, was saturated with sulphuric
acid, evaporated to dryness, and exhausted with absolute alcohol. The
solution, after evaporation of the alcohol, was treated with potash,
and yielded by distillation a volatile alkaloid having the odour of
conine.

From experiments made by one of us (F.) we can fully confirm the
observations of Felletár. We have obtained the volatile base in
question, and find it to have the smell of conine. It occurs both in
the pericarp and in the seeds, but in so small proportion that we
were unsuccessful in isolating it in sufficient quantity to allow of
accurate examination.

Dragendorff states (1871) that petroleum ether is the best solvent for
the alkaloid of capsicum; he obtained crystals of its hydrochlorate,
the aqueous solution of which was precipitated by most of the usual
tests, but not by tannic acid.

The colouring matter of capsicum fruits is sparingly soluble in
alcohol, but readily in chloroform. After evaporation, an intensely red
soft mass is obtained, which is not much altered by potash; it turns
first blue, then black with concentrated sulphuric acid, like many
other yellow colouring substances. By alcohol chiefly _palmitic_ acid
is extracted from the fruit, as shown by Thresh in 1877.

The fruits of _Capsicum fastigiatum_ have a somewhat strong odour; on
distilling consecutively two quantities, each of 50 lb., we obtained
a scanty amount of flocculent fatty matter, which possesses an odour
suggestive of parsley. Both this matter, as well as the distilled
water, were neutral to litmus paper, and the water tasteless. We
separated the latter, and exposed the remaining greasy mass to a
temperature of about 50° C., when it for the most part melted. The
clear liquid on cooling solidified, and now consisted of tufted
crystals, which we further purified by recrystallization from alcohol.
Thus about 2 centigrammes were obtained of a neutral white stearoptene,
having a decidedly aromatic, not very persistent taste, by _no
means acrid_, but rather like that of the essential oil of parsley.
The crystals melted at 38° C. On keeping them for some days at the
temperature of the water-bath, covered with a watch-glass, some drops
of essential oil were volatilized, which had the same taste and did
not solidify; the crystals were consequently accompanied by a liquid
oil. When kept for some days more in that condition, the crystals
themselves began to be volatilized, and the part remaining behind
acquired a brownish hue. This no doubt points out another impurity,
as we ascertained by the following experiment. With boiling solution
of potash, the stearoptene produces a kind of soap, which on cooling
yields a transparent jelly. If this is dissolved and diluted, it
becomes turbid by addition of an acid. This probably depends upon the
presence of a little fatty matter, a suggestion which is confirmed by
the somewhat offensive smell given off by our stearoptene if it is
heated in a glass tube.

Buchheim’s “Capsicol”[1665] is in our opinion a doubtful substance.

Thresh (1876-1877) succeeded in isolating a well defined, highly active
principle, the _Capsaicin_, from the extract which he obtained by
exhausting Cayenne pepper with petroleum. From the red liquor dilute
caustic lye removes capsaicin, which is to be precipitated in minute
crystals by passing carbonic acid through the alkaline solution. They
may be purified by recrystallizing them from either alcohol, ether,
benzine, glacial acetic acid, or hot bisulphide of carbon; in petroleum
capsaicin is but very sparingly soluble, yet dissolves abundantly on
addition of fatty oil. The latter being present in the pericarp is the
cause why capsaicin can be extracted by the above process.

The crystals of capsaicin are colourless and answer to the formula
C₉H₁₄O₂; they melt at 59° C. and begin to volatilize at 115° C.,
but decomposition can only be avoided by great care. The vapours of
capsaicin are of the most _dreadful acridity_, and even the ordinary
manipulation of that substance requires much precaution. Capsaicin is
not a glucoside; it is a powerful rubefacient, and taken internally
produces very violent burning in the stomach.

=Commerce=—Chillies or Pod Pepper are shipped from Zanzibar, Western
Africa and Natal, but no general statistics of the quantity imported
into Great Britain are accessible.

The exports from Sierra Leone in 1871 reached 7258 lb.[1666] The colony
of Natal, which produces Cayenne Pepper in the county of Victoria,
where sugar cane and coffee are also grown, shipped in the same year
9072 lb.[1667]

Official returns[1668] show that in 1871 Singapore imported 1071 cwt.
(119,952 lb.) of chillies, chiefly from Penang and Pegu. The spice is
largely consumed by the Chinese.

Bombay imported of dried chillies in the year 1872-3, 5567 cwt.
(623,504 lb.) principally from the Madras Presidency, and exported 3323
cwt.[1669]

=Uses=—Capsicum on account of its pungent properties is often
administered as a local stimulant in the form of gargle, and
occasionally as a liniment; and internally to promote digestion. In all
warm countries it is much employed as a condiment.


RADIX BELLADONNÆ.

_Belladonna Root_; F. _Racine de Belladone_; G. _Belladonnawurzel_.

=Botanical Origin=—_Atropa Belladonna_ L., a tall, glabrous or slightly
downy herb, with a perennial stock, native of central and Southern
Europe, where it grows in the clearings of woods. The plant extends
eastward to the Crimea, Caucasia and Northern Asia Minor. In Britain it
is chiefly found in the southern counties, but even of these it is a
doubtful native.

[1665] _Jahresbericht_ of Wiggers and Husemann, 1873. 567; also
_Yearbook of Pharm._ 1876. 251.

[1666] _Blue Book_ of the Colony of Sierra Leone for 1871.

[1667] Do. of Natal for 1871.

[1668] Do. of the Straits Settlements for 1871.

[1669] _Statement of the Trade and Navigation of Bombay for 1872-73_,
pt. ii. 58. 91.

In a few localities in England and France, as well as in North America,
the plant is cultivated for medicinal use.

=History=—Although a plant so striking as belladonna can hardly have
been unknown to the classical authors, it cannot with certainty be
identified in their writings.

Saladinus of Ascoli,[1670] who wrote an enumeration of medicinal plants
about A.D. 1450, names the leaves of both _Solatrum furiale_ and
_Solatrum minus_, the former of which is probably _Belladonna_. However
this may be, the first indubitable notice of it that we have met with,
is in the _Grand Herbier_ printed at Paris, probably about 1504.[1671]
The plant is also mentioned about this period as _Solatrum mortale_ or
_Dolwurtz_, in the writings of Hieronymus Brunschwyg.[1672]

In 1542 belladonna was well figured as _Solanum somniferum_ or
_Dollkraut_ by the German botanist Leonhard Fuchs, who fully recognized
its poisonous properties.[1673] Yet it was confounded by other writers
of this period as Tragus,[1674] who reproduced Fuchs’ figure as
“_Solanum hortense_!” _Strygium_ and _Strychnon_ were other names not
unfrequently applied to Atropa during the 16th and 17th centuries.

Matthiolus, who terms the plant _Solatrum majus_, states[1675] that
it is commonly called by the Venetians _Herba Bella donna_, from the
circumstance of the Italian ladies using a distilled water of the plant
as a cosmetic. Gesner[1676] was also familiar with the name Belladonna.
The introduction of the root of belladonna into British medicine is of
recent date, and is due to Mr. Peter Squire of London, who recommended
it as the basis of a useful anodyne liniment, about the year 1860.

=Description=—Belladonna has a large, fleshy, tapering root, 1 to 2
inches thick, and a foot or more in length, from which diverge stout
branches. Externally the fresh roots are of an earthy brown, rough with
cracks and transverse ridges. The bark is thick and juicy, and as well
as the more fibrous central portion, is internally of a dull creamy
white. A transverse section of the main root shows a distinct radiate
structure. The root has an earthy smell with but very little taste at
first, but a powerfully acrid after-taste is soon developed.

_Dried root of Belladonna_ is sold in rough irregular pieces of a
dirty greyish colour, whitish internally, breaking easily with a short
fracture, and having an earthy smell not unlike that of liquorice root.
The bark being probably the chief seat of the alkaloid, roots not
exceeding the thickness of the finger should be preferred. The drug
is for the most part imported from Germany, and is often of doubtful
quality. English-grown root purchased in a fresh state (the large and
old being rejected), then washed, cut into transverse segments and
dried by a gentle heat, furnishes a more reliable and satisfactory
article.

[1670] _Compendium Aromatariorum_, 1488.

[1671] _Le Grant Herbier en francoys, contenāt les qualitez, vertus
et proprietez des herbes_ etc., Paris (no date) 4°. cap. _De Solastro
rustico._

[1672] _Das destillier Buch_ (sub voce _Nachtschet Wasser_).
Strassburg, 1521, fol. 93 _b_. The figure probably refers to Atropa,
but that given in the edition of the same work of the year 1500 shows
_Solanum nigrum_.

[1673] _Historia Stirpium_, Basil. 1542. 689.

[1674] _De Stirpium ... historia_, Argentorati, 1552. 301.

[1675] _Comment. in lib. vi. Dioscoridis_, Venetiis, 1558. 533.

[1676] _De hortis Germaniæ_, Argentorat. 1561, fol. 282.

=Microscopic Structure=—There is a considerable structural difference
between the main root and its branches, the former alone containing
a distinct pith. This pith is included in a woody circle, traversed
by narrow medullary rays. In the outer part of the woody circle,
parenchymatous tissue is more prevalent than vascular bundles. The
transverse section of the branches of the root exhibits a central
vascular bundle instead of a medullary column. The outer vascular
bundles show no regular arrangement; and medullary rays are not clearly
obvious in the transverse section.

The woody parts, both of the main root and its branches, contain very
large dotted vessels accompanied by a prosenchymatous tissue. The cells
of the latter, however, are always thin-walled; the absence of proper
so-called ligneous tissue explains the easy fracture of the root.
Sometimes the prosenchyme in which the vessels are imbedded assumes
a brownish hue and a waxy appearance, and such parts exhibit a very
irregular structure.

In the cortical portion of belladonna root, many of the cells of the
middle layer, and likewise some of the central parts of the root, are
loaded with extremely small octahedric crystals of calcium oxalate.
But most of the parenchymatous cells are filled up with small starch
granules.

=Chemical Composition=—In 1833 Mein prepared from the root, and Geiger
and Hesse from the herb, the crystallizable alkaloid _Atropine_. The
researches of Lefort (1872) have proved that the roots contain it in
very variable proportions, the young being much richer in alkaloid than
the old.[1677] The maximum proportion obtained was 0·6 per cent.; this
was from root of the thickness of the finger. Large old roots, 7 or 8
years of age, afford from 0·25 to 0·31 per cent. They have besides a
smaller proportion of bark than young roots, and it is chiefly in the
bark that the alkaloid appears to reside. Manufacturers of atropine
employ exclusively the root.

Ludwig and Pfeiffer (1861), by decomposing atropine with potassium
chromate and sulphuric acid, obtained benzoic acid and propylamine.
Other products are formed when atropine is treated with strong
hydrochloric acid, baryta water or caustic soda, thus—_Atropine_,
C₁₇H₂₃NO₂ + H₂O = _Tropic Acid_, C₉H₁₀O₃ + _Tropine_, C₈H₁₅NO.

    Tropic acid, C₆H₅C(OH) {CH₃
                           {COOH,

being further boiled with the same agents is converted into

    atropic acid, C₆H₅C {CH₂
                        {COOH,

which, especially by using hydrochloric acid, is gradually transformed
into isotropic acid. Both these acids are isomeric to cinnamic acid,
C₉H₈O₂, but otherwise remarkably dissimilar.

Tropine is a strongly alkaline body, readily soluble both in water and
alcohol, and furnishing tabular crystals by the evaporation of its
solution in ether. Neither tropine nor tropic acid, it is stated by
Kraut (1863), is present in the leaves and root of belladonna.

Hübschmann (1858) detected in belladonna root a second but
uncrystallizable alkaloid, called _Belladonnine_; it has a resinous
aspect, is distinctly alkaline, and when heated emits, like atropine, a
peculiar odour.

[1677] For Lefort’s process for estimating atropine, see p. 458.

The root further contains, according to Richter (1837) and Hübschmann,
a fluorescent substance, as well as a red colouring matter called
_Atrosin_.[1678] The latter occurs in greatest abundance in the fruit,
and would probably repay further investigation.

=Uses=—Belladonna root is chiefly used for the preparation of atropine,
which is employed for dilating the pupil of the eye. A liniment made
with belladonna root is used for the relief of neuralgic pains.

=Adulteration=—We may point out that the roots of _Mandragora
microcarpa_, _M. officinarum_, and _M. vernalis_ Bertoloni are very
nearly allied to the root under notice, both in external appearance
and in their structure. They are not likely to be confounded with
Belladonna root, their mother plants being indigenous in the South of
Europe.


FOLIA BELLADONNÆ.

_Belladonna Leaves_; F. _Feuilles de Belladone_; G. _Tollkraut_.

=Botanical Origin=—_Atropa Belladonna_ L. (p. 455).

=History=—Belladonna Leaves and the extract prepared from them
were introduced into the London Pharmacopœia of 1809. For further
particulars regarding the history of belladonna, see the preceding
article.

=Description=—Belladonna or Deadly Nightshade produces thick, smooth
herbaceous stems, which attain a height of 4 to 5 feet. They are simple
in their lower parts, then usually 3-forked, and afterwards 2-forked,
producing in their upper branches an abundance of bright green leaves,
arranged in unequal pairs, from the bases of which spring the solitary,
pendulous, purplish, bell-shaped flowers, and large shining black
berries.

The leaves are 3 to 6 inches long, stalked, broadly ovate, acuminate,
attenuated at the base, soft and juicy; those of barren roots are
alternate and solitary. The young shoots are clothed with a soft, short
pubescence, which on the calyx is somewhat more persistent, assuming
the character of viscid, glandular hairs. If bruised, the leaves emit
a somewhat offensive, herbaceous odour which is destroyed by drying.
When dried, they are thin and friable, of a brownish-green on the upper
surface and greyish beneath, with a disagreeable, faintly bitter taste.
Of fresh leaves 100 lb. yield 16 lb. of dried (Squire).

=Chemical Composition=—The important constituent of belladonna leaves
is _Atropine_. Lefort (1872)[1679] estimated its amount by exhausting
the leaves previously dried at 100° C. by means of dilute alcohol,
concentrating the tincture, and throwing down the alkaloid with a
solution of iodohydrargyrate of potassium. The precipitate thus
obtained was calculated to contain 33·25 per cent. of atropine. Lefort
examined leaves from plants both cultivated and growing wild in the
environs of Paris, and gathered either before or after flowering. He
found cultivation not to affect the percentage of alkaloid,—that the
leaves of the young plant were rather less rich than those taken at the
period of full inflorescence,—and that the latter (dried) yielded 0·44
to 0·48 per cent. of atropine.

[1678] Gmelin, _Chemistry_, xvii. (1866) 1.

[1679] _Journ. de Pharm._ xv. (1872) 269. 341.

Larger percentages are recorded by Dragendorff;[1680] as much as 0·95
per cent. of atropine as obtained from the dried unripe fruits, 0·83
from the dried leaves, 0·21 from the root. The estimation was performed
in nearly the same way as that followed by Lefort.

Belladonna herb yields _Asparagin_, which according to Biltz (1839)
crystallizes out of the extract after long keeping. The crystals found
in the extract by Attfield (1862) were however chloride and nitrate
of potassium. The same chemist obtained by dialysis of the juice of
belladonna, nitrate of potassium, and square prisms of a salt of
magnesium containing some organic acid; the juice likewise affords
ammonia.[1681] The dried leaves yielded us 14·5 per cent. of ash
consisting mainly of calcareous and alkaline carbonates.

=Uses=—The fresh leaves are used for making _Extractum Belladonnæ_, and
the dried for preparing a tincture. They should be gathered while the
plant is well in flower.


HERBA STRAMONII.

_Stramonium_, _Thornapple_; F. _Herbe de Stramoine_; G.
_Stechapfelblätter_.

=Botanical Origin=—_Datura[1682] Stramonium_ L., a large,
quick-growing, upright annual, with white flowers like a convolvulus,
and ovoid spiny fruits. It is now found as a weed of cultivation in
almost all the temperate and warmer regions of the globe. In the south
of England it is often met with in rich waste ground, chiefly near
gardens or habitations.

=History=—The question of the native country and early distribution of
_D. Stramonium_ has been much discussed by botanical writers. Alphonse
De Candolle,[1683] who has ably reviewed the arguments advanced in
favour of the plant being a native respectively of Europe and America
or Asia, enounces his opinion thus:—that _D. Stramonium_ L. appears to
be indigenous to the Old World, probably the borders of the Caspian
Sea or adjacent regions, but certainly not of India; that it is very
doubtful if it existed in Europe in the time of the ancient Roman
Empire, but that it appears to have spread itself between that period
and the discovery of America.

Stramonium was cultivated in London towards the close of the 16th
century by Gerarde, who received the seed from Constantinople and
freely propagated the plant, of the medicinal value of which he had a
high opinion. The use of the herb in more recent times is due to the
experiments of Störck.[1684]

[1680] _Werthbestimmung stark wirkender Droguen_, Petersburg, 1876. 28.

[1681] The fresh juice kept for a few days has been known to evolve
_red vapours_ (nitrous acid?) when the vessel containing it was
opened.—H. S. Evans in _Pharm. Journ._ ix. (1850) 260.

[1682] _Datura_ from the Sanskrit name _D’hustùra_, applied to _D.
fastuosa_ L. The origin of the word _Stramonium_ is not known to us.

[1683] _Géographie Botanique_, ii (1855) 731.

[1684] Libellus quo demonstratur _Stramonium_, Hyoscyamum, Aconitum ...
esse remedia, Vindob. 1762.

=Description=—Stramonium produces a stout, upright, herbaceous green
stem, which at a short distance from the ground, throws out spreading
forked branches, in the axil of each fork of which arises a solitary
white flower, succeeded by an erect, spiny, ovoid capsule. At each
furcation and directed outwards is a large leaf. This arrangement of
parts is repeated, and as the plant grows vigorously, it often becomes
much branched and acquires in the course of the summer a considerable
size.

The leaves of stramonium have long petioles, are unequal at the base,
oval, acuminate, sinuate-dentate with large irregular pointed teeth
or lobes, downy when young, glabrous at maturity. When fresh they are
somewhat firm and juicy, emitting when handled a disagreeable fœtid
smell. The larger leaves of plants of moderate growth attain a length
of 6 to 8 or more inches.

For medicinal purposes, the entire plants are pulled up, the leaves and
younger shoots are stripped off, quickly dried, and then broken and cut
into short lengths, so as to be conveniently smoked in a pipe, that
being the method in which the drug is chiefly consumed in England. The
offensive smell of the fresh plant is lost by drying, being replaced
by a rather agreeable tea-like odour. The dried herb has a bitterish
saline taste.

=Chemical Composition=—The leaves of stramonium contain, in common with
the seeds, the alkaloid _Daturine_ (see p. 461), but in extremely small
proportion, not exceeding in fact ²/₁₀ to ³/₁₀ per mille. They are rich
in saline and earthy constituents; selected leaves dried at 100° C.
yielded us 17·4 per cent. of ash.

=Uses=—Scarcely employed in any other way than in smoking like tobacco
for the relief of asthma.—Col. Grant (1871) found the herb to be smoked
in pipes by the Nubians for chest-complaint.

=Substitute=—_Datura Tatula_ L.—This plant is closely allied to _D.
Stramonium_ L., propagating itself on rich cultivated ground with
nearly the same facility; but it is not so generally diffused.

De Candolle is of opinion that it is indigenous to the warmer parts of
America, whence it was imported into Europe in the 16th century, and
naturalized first in Italy, and then in South-Western Europe. By many
botanists it has been united to _D. Stramonium_, but Naudin,[1685]
who has studied both plants with the greatest attention, especially
with reference to their hybrids, is decidedly in favour of considering
them distinct. _D. Tatula_ differs from _D. Stramonium_ in having
stem, petiole, and nerves of leaves _purplish_ instead of _green_; and
corolla and anthers of a _violet_ colour instead of _white_,—characters
which, it must be admitted, are of very small botanical value.

_D. Tatula_ has been recommended for smoking in cases of asthma, on
the ground of its being _stronger_ than _D. Stramonium_; but we are
not aware of any authority as to the comparative strength of the two
species.

[1685] _Comptes Rendus_, lv. (1862) 321.


SEMEN STRAMONII.

_Stramonium Seeds_; F. _Semences de Stramoine_; G. _Stechapfelsamen_.

=Botanical Origin=—_Datura Stramonium_ L., see preceding article.

=Description=—The spiny, ovoid capsule of stramonium opens at the
summit in four regular valves. It is bilocular, with each cell
incompletely divided into two, and contains a large number (about 400)
of flattened, kidney-shaped seeds. The seeds are blackish or dark
brown, about 2 lines long and ½ a line thick, thinning off towards
the hilum which is on the straighter side. The surface of the seed is
finely pitted and also marked with a much coarser series of shallow
reticulations or rugosities. A section parallel to the faces of the
seed exhibits the long, contorted embryo, following the outline of the
testa, and bedded in the oily white albumen. The cylindrical form of
the embryo is seen in a transverse section of the seed.

The seeds have a bitterish taste, and when bruised a disagreeable
odour. When the entire seeds are immersed in dilute alcohol, they
afford a tincture displaying a beautiful green fluorescence, turning
yellow on addition of ammonia.

=Microscopic Structure=—The testa is formed of a row of radially
extended, thick-walled cells. They are not of a simply cylindrical
form, but their walls are sinuously bent in and out in the direction
of their length. Viewed in a direction tangential to the surface, the
cells appear as if indented one into the other. Towards the surface of
the seed the cell-walls are elevated as dark brown tubercles and folds,
giving to the seed its reticulated and pitted surface. The albumen and
embryo exhibit the usual contents, namely fatty oil and albuminoid
substances.[1686]

=Chemical Composition=—The active constituent of stramonium seeds is
the highly poisonous alkaloid _Daturine_, of which they afford only
about ⅒ per cent., while the leaves and roots contain it in still
smaller proportion.[1687] Daturine was discovered in 1833 by Geiger
and Hesse, and regarded as identical with atropine by A. von Planta
(1850), who found it to have the same composition as that alkaloid.
The two bodies exhibit the same relations as to solubility and fusing
point (88-90° C.); and they also agree in crystallizing easily. The
experiments of Schroff (1852), tending to show that although daturine
and atropine act in the same manner, the latter has twice the poisonous
energy of the former, raised a further question as to the identity of
the two alkaloids. Poehl (1876) also stated solutions of daturine to
be levogyrate, those of atropine being devoid of rotatory power. From
the observations of Erhard (1866), it would appear that the crystalline
form of some of the salts of atropine and daturine is different. In
stramonium seeds daturine appears to be combined with malic acid. The
seeds yielded to Cloëz (1865) 2·9 per cent. of ash and 25 per cent. of
fixed oil.

=Uses=—Stramonium seeds are prescribed in the form of extract or
tincture as a sedative or narcotic.

[1686] We have not seen W. G. Mann, _Onderzoek van het zaad van Datura
Stramonium_, Enschede, 1875.

[1687] Günther in Wiggers and Husemann’s _Jahresbericht_ for 1869. 54.


SEMEN ET FOLIA DATURÆ ALBÆ.

_Seeds and Leaves of the Indian or White-flowered Datura._

=Botanical Origin=—_Datura alba_ Nees, a large, spreading annual plant,
2 to 6 feet high, bearing handsome, tubular, white flowers 5 to 6
inches long. The capsules are pendulous, of depressed globular form,
rather broader than high, covered with sharp tubercles or thick short
spines. They do not open by regular valves as in _D. Stramonium_, but
split in different directions and break up into irregular fragments.

_D. alba_ appears to be scarcely distinct from _D. fastuosa_ L.
Both are common in India, and are grown in gardens in the south of
Europe.[1688]

=History=—The mediæval Arabian physicians were familiar with _Datura
alba_, which is well described by Ibn Baytar[1689] under precisely the
same Arabic name (_Jouz-masal_) that it bears at the present day; they
were also fully aware of its poisonous properties.

Garcia de Orta[1690] (1563) observed the plant in India, and has
narrated that its flowers or seeds are put into food to intoxicate
persons it was designed to rob. It was also described by Christoval
Acosta, who in his book on Indian drugs[1691] mentions two other
varieties, one of them with yellow flowers, the seeds of either being
very poisonous, and often administered with criminal intent, as well
as for the cure of disease. Graham[1692] says of the plant that it
possesses very strong narcotic properties, and has on several occasions
been fatally used by Bombay thieves, who have administered it in order
to deprive their victims of the power of resistance.

The seeds and fresh leaves have a place in the _Pharmacopœia of India_,
1868.

=Description=—The seeds of _D. alba_ are very different in appearance
from those of _D. Stramonium_, being of a light yellowish-brown, rather
larger size, irregular in shape and somewhat shrivelled. Their form has
been likened to the human ear; they are in fact obscurely triangular or
flattened-pearshaped, the rounded end being thickened into a sinuous,
convoluted, triple ridge, while the centre of the seed is somewhat
depressed. The hilum runs from the pointed end nearly half-way up the
length of the seed. The testa is marked with minute rugosities, but is
not so distinctly pitted as in the seed of the _D. Stramonium_; it is
also more developed, exhibiting in section large intercellular spaces
to which are due its spongy texture. The seeds of the two species agree
in internal structure as well as in taste; but those of _D. alba_ do
not give a fluorescent tincture.

[1688] Seeds of _D. alba_ sent to us from Madras by Dr. Bidie, were
sown by our friend M. Naudin of Collioure (Pyrénées Orientales), and
produced the plant under three forms, viz.:—1. The true _D. alba_ as
figured in Wight’s _Icones_.—2. Plants with flowers, violet without and
nearly white within (_D. fastuosa_).—3. Plants with double corollas of
large size and of a yellow colour.

[1689] Sontheimer’s translation, i. 269.

[1690] _Aromatum historia_, 1574, lib. 2. c. 24.

[1691] _Tractado de las Drogas ... de las Indias Orientales_, Burgos,
1578. 85.

[1692] _Catalogue of Bombay Plants_, 1839. 141.

The leaves, which are only employed in a fresh state, are 6 to 10
inches in length, with long stalks, ovate, often unequal at the base,
acuminate, coarsely dentate with a few spreading teeth. They evolve an
offensive odour when handled.

=Microscopic Structure=—The testa is built up of the same tissues as
in _D. Stramonium_, but the thick-walled cells constituting the spongy
part are far larger, and distinctly show numerous secondary deposits,
making a fine object for the microscope.

=Chemical Composition=—Neither the seeds nor the leaves of _D. alba_
have yet been examined chemically, but there can scarcely be any doubt
that their very active properties are due to _Daturine_, for the
preparation of which the former would probably be the best source.

=Uses=—The seeds in the form of tincture or extract have been employed
in India as a sedative and narcotic, and the fresh leaves, bruised and
made into a poultice with flour, as an anodyne application.


FOLIA HYOSCYAMI.

_Henbane Leaves_; F. _Feuilles de Jusquiame_; G. _Bilsenkraut_.

=Botanical Origin=—_Hyoscyamus niger_ L., a coarse, erect herb, with
soft, viscid, hairy foliage of unpleasant odour, pale yellowish flowers
elegantly marked with purple veins, and 5-toothed bottle-shaped calyx.
It is found throughout Europe from Portugal and Greece to Central
Norway and Finland, in Egypt, Asia Minor, the Caucasus, Persia, Siberia
and Northern India. As a weed of cultivation it now grows also in North
America[1693] and Brazil. In Britain it occurs wild, chiefly in waste
places near buildings; and is cultivated for medicinal use.

Henbane exists under two varieties, known as _annual_ and _biennial_,
but scarcely presenting any other distinctive character.

_Biennial Henbane_ (_Hyoscyamus niger_ var. α. _biennis_) is most
esteemed for pharmaceutical preparations. It is raised by seed, the
plant producing the first year only a rosette of luxuriant stalked
leaves, 12 or more inches in length. In the second, it throws up a
flower stem of 2 to 3 feet in height, and the whole plant dies as the
fruit matures.

_Annual Henbane_ (_H. niger_ var. β. _annua_, vel _agrestis_) is a
smaller plant, coming to perfection in a single season. It is the usual
wild form, but it is also grown by the herbalists.[1694]

=History=—Hyoscyamus, under which name it is probable the nearly allied
South European species, _H. albus_ L., was generally intended, was
medicinal among the ancients, and particularly commended by Dioscorides.

In Europe, henbane has been employed from remote times. Benedictus
Crispus, archbishop of Milan, in a work written shortly before A.D.
681, notices it under the name of _Hyoscyamus_ and _Symphoniaca_.[1695]
In the 10th century, its virtues were particularly recorded by Macer
Floridus[1696] who called it _Jusquiamus_.

[1693] It had become naturalized in North America prior to 1672,
as we find it mentioned by Josselyn in his _New England’s Rarities
discovered_ (Lond. 1672) among the plants “sprung up since the English
planted and kept cattle in New England.”

[1694] _Pharm. Journ._ i. (1860) 414.

[1695] S. de Renzi, _Collectio Salernitana_, Napoli, i. (1852) 74. 84.

[1696] _De Viribus Herbarum_, edited by Choulant, Lips. 1832. 108.

Frequent mention is made of it in the Anglo-Saxon works on medicine of
the 11th century,[1697] in which it is called _Henbell_, and sometimes
_Belene_, the latter word perhaps traceable in βιλινουντία, which
Dioscorides[1698] gives as the Gallic designation of the plant. In the
13th century henbane was also used by the Welsh “Physicians of Myddvai.”

The word _Hennibone_, with the Latin and French synonyms _Jusquiamus_
and _Chenille_, occurs in a vocabulary of the 13th century;
and _Hennebane_ in a Latin and English vocabulary of the 15th
century.[1699] In the _Arbolayre_, a printed French herbal of the 15th
century,[1700] we find the plant described as _Hanibane_ or _Hanebane_
with the following explanation—“Elle est aultrement appeler cassilago
et aultrement simphoniaca. La semence proprement a nom jusquiame
ou hanebane, et herbe a nom cassilago....” Both _Hyoscyamus_ and
_Jusquiamus_ are from the Greek Ὑοσκύαμος, i.e. _Hog-bean_.

Though a remedy undeniably potent, henbane in the first half of the
last century had fallen into disuse. It was omitted from the London
pharmacopœias of 1746 and 1788, and restored only in 1809. Its
re-introduction into medicine was chiefly due to the experiments and
recommendations of Störck.[1701]

During the middle ages the seeds and roots of henbane were also much
used.

=Description=—The stems of henbane, whether of the annual or biennial
form, are clothed with soft, viscid, hairy leaves, of which the
upper constitute the large, sessile, coarsely toothed bracts of the
unilateral flower-spike. The middle leaves are more toothed and
subamplexicaul. The lower leaves are stalked, ovate-oblong, coarsely
dentate, and of large size. The stems, leaves, and calyces of henbane
are thickly beset with long, soft, jointed hairs; the last joint of
many of these hairs exudes a viscid substance occasioning the fresh
plant to feel clammy to the touch. In the cultivated plant, the
hairiness diminishes.

After drying, the broad light-coloured midrib becomes very conspicuous,
while the rest of the leaf shrinks much and acquires a greyish green
hue. The drug derived from the flowering plant as found in commerce is
usually much broken. The fœtid, narcotic odour of the fresh leaves is
greatly diminished by drying. The fresh plant has but little taste.

Dried henbane is sold under three forms, which are not however
generally distinguished by druggists. These are 1. _Annual plant_,
foliage and green tops. 2. _Biennial plant_, leaves of the first year.
3. _Biennial plant_, foliage and green tops. The third form is always
regarded as the best, but no attempt has been made to determine with
accuracy the relative merits of the three sorts.

[1697] _Leechdoms etc. of Early England_, iii. (1866) 313.

[1698] Lib. iv. c. 69. (ed. Sprengel).

[1699] Wright, _Volume of Vocabularies_, 1857. 141. 265.

[1700] See p. 148, note 3, also Brunet, _Manuel du Libraire_, i. (1860)
377.

[1701] See p. 459, note 5.

=Chemical Composition=—_Hyoscyamine_, the most important among the
constituents of henbane, was obtained in an impure state by Geiger
and Hesse in 1833. Höhn in 1871 first isolated it from the seeds,
which are far richer in it than the leaves.[1702] The seeds are
deprived of the fatty oil (26 per cent.) and treated with spirit of
wine containing sulphuric acid, which takes out the hyoscyamine in
the form of sulphate. The alcohol is then evaporated and tannic acid
added; the precipitate thus obtained is mixed with lime and exhausted
with alcohol. The hyoscyamine is again converted into a sulphate,
the aqueous solution of which is then precipitated with carbonate
of sodium, and the alkaloid dissolved by means of ether. After the
evaporation of the ether, hyoscyamine remains as an oily liquid which
after some time concretes into wart-like tufted crystals, soluble in
benzol, chloroform, ether, as well as in water. Höhn and Reichardt
assign to hyoscyamine the formula C₁₅H₂₃O₃. The seeds yield of it only
0·05 per cent.

Hyoscyamine is easily decomposed by caustic alkalis. By boiling with
baryta in aqueous solution, it is split into _Hyoscine_, C₆H₁₃N, and
_Hyoscinic Acid_, C₉H₁₀O₃. The former is a volatile oily liquid of a
narcotic odour and alkaline reaction. By keeping it over sulphuric
acid it crystallizes and also yields crystallized salts; hyoscine may
be closely allied to conine, C₈H₁₅N. Hyoscinic acid, a crystallizable
substance having an odour resembling that of empyreumatic benzoic
acid.[1703] It melts, according to Höhn, at 105°; tropic acid (see p.
457), melting at 118°, agrees so very nearly with hyoscinic acid that
further researches will probably prove these acids to be identical.

Another process for extracting hyoscyamine is due (1875) to Thibaut. He
removes by bisulphide of carbon the fatty oil from the powdered seeds,
and exhausts them with alcohol slightly acidulated by tartaric acid.
The alcohol being distilled off, the author precipitates the alkaloid
by means of a solution containing 6 per cent. of iodide of potassium
and 3 per cent. iodine. By decomposing the precipitate with sulphurous
acid, hydroiodic acid and sulphate of hyoscyamine are formed. The
latter is dried up at 35° with magnesia and the hyoscyamine extracted
by alcohol or chloroform. The crystals melt at 90°. Thibaut found the
alkaloid thus prepared from seeds differing from that yielded by the
leaves, the latter having a somewhat strong odour.

Attfield[1704] has pointed out that extract of henbane is rich in
nitrate of potassium and other inorganic salts. In the leaves, the
amount of nitrate is, according to Thorey,[1705] largest before
flowering, and the same observation applies to hyoscyamine.

=Uses=—Henbane in the form of tincture or extract is administered
as a sedative, anodyne or hypnotic. The impropriety of giving it in
conjunction with free potash or soda, which render it perfectly inert,
has been demonstrated by the experiments of Garrod.[1706] Hyoscyamine,
like atropine, powerfully dilates the pupil of the eye.

[1702] From the experiments of Schoonbroodt (1868), there is reason
to believe that the active principle of henbane can be more easily
extracted from the _fresh_ than from the _dried_ plant.

[1703] I have had the opportunity of examining the above substances as
prepared by the said chemists.—F. A. F. July 1871.

[1704] _Pharm. Journ._ iii. (1862) 447.

[1705] Wiggers and Husemann, _Jahresbericht_, 1869. 56.

[1706] _Pharm. Journ._ xvii. (1858) 462; xviii. (1859) 174.

=Substitutes=—_Hyoscyamus albus_ L., a more slender plant than
_H. niger_ L., with stalked leaves and bracts, a native of the
Mediterranean region, is sometimes used in the south of Europe as
medicinal henbane. _H. insanus_ Stocks, a plant of Beluchistan, is
mentioned in the _Pharmacopœia of India_ as of considerable virulence,
and sometimes used for smoking.


FOLIA TABACI.

_Herba Nicotianæ_; _Tobacco_; F. _Tabac_; G. _Tabakblätter_.

=Botanical Origin=—_Nicotiana Tabacum_ L.—The common Tobacco plant is
a native of the New World, though not now known in a wild state. Its
cultivation is carried on in most temperate and subtropical countries.

=History=—It is stated by C. Ph. von Martius[1707] that the practice
of smoking tobacco has been widely diffused from time immemorial among
the natives of South America, as well as among the inhabitants of the
valley of the Mississippi as far north as the plant can be cultivated.

The Spaniards became acquainted with tobacco when they landed in Cuba
in 1492, and on their return introduced it into Europe for the sake
of its medicinal properties. The custom of inhaling the smoke of the
herb was learnt from the Indians, and by the end of the 16th century
had become generally known throughout Spain and Portugal, whence it
passed into the rest of Europe, and into Turkey, Egypt, and India,
notwithstanding that it was opposed by the severest enactments both of
Christian and Mahommedan governments. It is commonly believed that the
practice of smoking tobacco was much promoted in England, as well as in
the north of Europe generally, by the example of Sir Walter Raleigh and
his companions.

Tobacco was introduced into China, probably by way of Japan or Manila,
during the 16th or 17th century, but its use was prohibited by the
emperors both of the Ming and Tsing dynasties. It is now cultivated in
most of the provinces, and is universally employed.[1708]

The first tolerably exact description of the tobacco plant is that
given by Gonzalo Fernandez de Oviedo y Valdés, governor of St. Domingo,
in his _Historia general de las Indias_,[1709] printed at Seville in
1535. In this work, the plant is said to be smoked through a branched
tube of the shape of the letter =Y=, which the natives call _Tabaco_.

It was not until the middle of the 16th century that growing tobacco
was seen in Europe,—first at Lisbon, whence the French ambassador, Jean
Nicot, sent seeds to France in 1560 as those of a valuable medicinal
plant, which was even then diffused throughout Portugal.[1710]

Monardes,[1711] writing in 1571, speaks of tobacco as brought to Spain
a few years previously, and valued for its beauty and for its medicinal
virtues. Of the latter he gives a long account, noticing also the
methods of smoking and chewing the herb prevalent among the Indians. He
also supplies a small woodcut representing the plant, which he states
to have white flowers, red in the centre.

[1707] _Beiträge zur Ethnographie und Sprachenkunde Americas, zumal
Brasiliens_, i. (1867) 719.

[1708] Mayers in _Hong Kong Notes and Queries_, May, 1867; F. P. Smith,
_Mat. Med. and Nat. Hist. of China_, 1871. 219.

[1709] Lib. v. c. 2.

[1710] Nicot, _Thrésor de la langue Françoyse_, Paris, 1606. 429.

[1711] _Segunda parte del libro de las cosas que se traen de nuestras
Indias occidentales, que sirven al uso de medicina._ Do se trata del
Tabaco ..., Sevilla, 1571, 3.

Jacques Gohory,[1712] who cultivated the plant in Paris at least as
early as 1572, describes its flowers as shaded with red, and enumerates
various medicinal preparations made from it.

In the _Maison Rustique_ of Charles Estienne, edition of 1583, the
author gives a “_Discours sur la Nicotiane ou Petum mascle_,” in which
he claims for the plant the first place among medicinal herbs, on
account of its singular and almost divine virtues.

The cultivation of tobacco in England, except on a very small scale in
a physic garden, has been prohibited by law[1713] since 1660.

=Description=—Amongst the various species of _Nicotiana_ cultivated
for the manufacturing of smoking tobacco and snuff, _N. Tabacum_ is
by far the most frequent, and is almost the only one named in the
pharmacopœias as medicinal. Its simple stem, bearing at the summit a
panicle of tubular pink flowers, and growing to the height of a man,
has oblong, lanceolate simple leaves, with the margin entire. The lower
leaves, more broadly lanceolate, and about 2 feet long by 6 inches
wide, are shortly stalked. The stem-leaves are semi-amplexicaul, and
decurrent at the base. Cultivation sometimes produces cordate-ovate
forms of leaf, or a margin more or less uneven, or nearly revolute.

All the herbaceous parts of the plant are clothed with long soft hairs,
made up of broad, ribbon-like, striated cells, the points of which
exude a glutinous liquid. Small sessile glands are situated here and
there on the surface of the leaf.[1714] The lateral veins proceed from
the thick midrib in straight lines, at angles of 40° to 75°, gently
curving upwards only near the edge. In drying, the leaves become
brittle and as thin as paper, and always acquire a brown colour. Even
by the most careful treatment of a single leaf, it is not possible to
preserve the green hue.

The smell of the fresh plant is narcotic; its taste bitter and
nauseous. The characteristic odour of dried tobacco is developed during
the process of curing.

=Chemical Composition=—The active principle of tobacco, first isolated
in 1828 by Posselt and Reimann, is a volatile, highly poisonous
alkaloid termed _Nicotine_, C₁₀H₁₄N₂. It is easily extracted from
tobacco by means of alcohol or water, as a malate, from which the
alkaloid can be separated by shaking it with caustic lye and ether. The
ether is then expelled by warming the liquid, which finally has to be
mixed with slaked lime and distilled in a stream of hydrogen, when the
nicotine begins to come over at about 200° C.

[1712] _Instruction sur l’herbe Petum ditte en France l’herbe de la
Royne ou Médicée_ ... Paris, 1572.

[1713] 12 Car. II. c. 34; 15 Car. II. c. 7.—For further information
on the history of tobacco, see Tiedemann, _Geschichte des Tabaks_,
Frankfurt, 1854.—We have not consulted Fairholt, _Tobacco, its
History_, Lond. 1859.

[1714] Microscopic structure of tobacco leaves. See Pocklington,
_Pharm. Journal_, v. (1874) 301.

Nicotine is a colourless oily liquid, of sp. gr. 1·027 at 15° C.,
deviating the plane of polarization to the left; it boils at 247° and
does not concrete even at -10° C. It has a strongly alkaline reaction,
an unpleasant odour, and a burning taste. It quickly assumes a brown
colour on exposure to air and light; and appears even to undergo an
alteration by repeated distillation in an atmosphere deprived of
oxygen. Nicotine dissolves in water, but separates on addition of
caustic potash; it occurs in the dried leaves to the extent of about 6
per cent., but is subject to great variation. The seeds of tobacco are
stated by Kosutany[1715] as grown in Hungary to contain from 0·28 to
0·67 per cent. of the alkaloid.

It has not been met with in tobacco-smoke by Vohl and Eulenberg
(1871), though other chemists assert its occurrence. The vapours
were found by the former to contain numerous basic substances of the
picolinic series, and ceded to caustic potash, hydrocyanic acid,[1716]
sulphuretted hydrogen, several volatile fatty acids, phenol and
creasote. There was further observed in the imperfect combustion
of tobacco the formation of laminæ fusible at 94° C., and having a
composition C₁₉H₁₈. Oxide of carbon is also largely met with.

Tobacco leaves, whether fresh or dried, yield when distilled with water
a turbid distillate in which, as observed by Hermbstädt in 1823, there
are formed, after some days, crystals of _Nicotianin_ or _Tobacco
Camphor_. According to J. A. Barral, nicotianin contains 7·12 per cent.
of nitrogen (?). By submitting 4 kilogrammes of good tobacco of the
previous year to distillation with much water, we obtained nicotianin,
floating on the surface of the distillate, in the form of minute
acicular crystals, which we found to be devoid of action on polarized
light. The crystals have no peculiar taste, at least in the small
quantity we tried; they have a tobacco-like smell, perhaps simply due
to the water adhering to them. When an attempt was made to separate
them by a filter, they entirely disappeared, being probably dissolved
by an accompanying trace of essential oil. The clear water showed an
alkaline reaction partly due to _nicotine_; this was proved by adding
a solution of tannic acid, which caused a well-marked turbidity.
Nicotianine is in our opinion a fatty acid contaminated with a little
volatile oil as in the case of Capsicum (see page 454), or Iris (see
article Rhizome Iridis).

Among the ordinary constituents of leaves, tobacco contains albumin,
resin and gum. In smoking, these substances, as well as the cellulose
of the thick midrib, would yield products not agreeable to the
consumer. The manufacturer therefore discards the midrib, and
endeavours by further preparation to ensure at least the partial
destruction of these unwelcome constituents, as well as the formation
of certain products of fermentation (ferment-oils), which may perhaps
contribute to the aroma of tobacco, especially when saccharine
substances, liquorice, or alcohol, are added in the maceration to which
tobacco is subjected.

Tobacco leaves are remarkably rich in inorganic constituents, the
proportion varying from 16 to 27 per cent. According to Boussingault,
they contain when dry about 1 per cent. of phosphoric acid, and from 3
to 5 per cent. of potash, together with 2½ to 4½ per cent. of nitrogen
partly in the form of nitrate, so that to enable the tobacco plant to
flourish, it must have a rich soil or continual manuring.[1717]

[1715] Dragendorff’s _Jahresbericht_, 1874. 98.

[1716] Poggiale and Marty (1870) stated hydrocyanic acid to be absent.

[1717] For further particulars on the chemistry of tobacco cultivation
see Boussingault, _Ann. de Chim. et de Phys._ ix. (1866) 50.

The lime, amounting to between a quarter and a half of the entire
quantity of ash, is in the leaf combined with organic acids, especially
malic, perhaps also citric. The proportion of potash varies greatly,
but may amount to about 30 per cent. of the ash.

=Commerce=—There were imported into the United Kingdom in the year
1872, 45,549,700 lb. of unmanufactured tobacco, rather more than half
of which was derived from the United States of America. The total value
of the commodity thus imported was £1,563,382; and the duty levied upon
the quantity retained for home consumption amounted to £6,694,037. In
1876 the consumption of tobacco had increased to 47,000,000 lb., _i.e._
1½ lb. per head of the population.

In the United States 559,049 acres of land being in 1875 under
cultivation with tobacco yielded a crop of 367,000,000 lb.

=Uses=—Tobacco has some reputation in the removal of alvine
obstructions, but it is a medicine of great potency and is very rarely
used.

=Substitutes=—Of the other species of _Nicotiana_ cultivated as
_Tobacco_, _N. rustica_ L. is probably the most extensively grown. It
is easily distinguished by its greenish yellow flowers, and its stalked
ovate leaves. In spite of their coarser texture, the leaves dry more
easily than those of _N. Tabacum_, and with some care may even be made
to retain their green colour. _N. rustica_ furnishes _East Indian
Tobacco_, also the kinds known as _Latakia_ and _Turkish Tobacco_.

_N. persica_ Lindl. yields the tobacco of Shiraz. _N. quadrivalvis_
Pursh, _N. multivalvis_ Lindl. and _N. repanda_ Willd. are also
cultivated plants, the last named, a plant of Havana, being used in the
manufacture of a much valued kind of cigar.




SCROPHULARIACEÆ.


FOLIA DIGITALIS.

_Foxglove Leaves_; F. _Feuilles de Digitale_; G. _Fingerhutblätter_.

=Botanical Origin=—_Digitalis purpurea_ L., an elegant and stately
plant, common throughout the greater part of Europe, but preferring
siliceous soils and generally absent from limestone districts. It is
found on the edges of woods and thickets, on bushy ground and commons,
becoming a mountain plant in the warm parts of Europe. It occurs in the
island of Madeira, in Portugal, Central and Southern Spain, Northern
Italy, France, Germany, the British Isles and Southern Sweden, and in
Norway as far as 63° N. lat.; it is however very unequally distributed,
and is altogether wanting in the Swiss Alps and the Jura.[1718] As a
garden plant it is well known.

=History=—The Welsh “Physicians of Myddvai” appear to have frequently
made use of foxglove for the preparation of external medicines.[1719]
Fuchs[1720] and Tragus[1721] figured the plant; the former gave it
the name of _Digitalis_, remarking that up to the time at which he
wrote, there was none for the plant in either Greek or Latin. At that
period it was regarded as a violent medicine. Parkinson recommended
it in 1640 in the “Theatrum botanicum,” and it had a place in the
London Pharmacopœia of 1650 and in several subsequent editions. The
investigation of its therapeutic powers (1776-9) and its introduction
into modern practice are chiefly due to Withering, a well-known English
botanist and physician.[1722]

[1718] Dr. R. Cunningham found (1868) _Digitalis purpurea_ completely
naturalized about San Carlos in the Island of Chiloe in Southern Chili.

[1719] _Meddygon Myddfai_ (see Appendix) in many places.

[1720] _De Hist. Stirpium_, 1542. 892.

[1721] _De Stirpium ... nomenclaturis_, etc. 1552—“_Campanula
sylvestris seu Digitalis_.”

[1722] Withering (William), _Account of the Foxglove_, Birmingham,
1785. 8°.

The word _foxglove_ is said to be derived from the Anglo-Saxon
_Foxes-glew_, i.e. _fox-music_, in allusion to an ancient musical
instrument consisting of bells hung on an arched support.[1723] In the
Scandinavian idioms the plant bears likewise the name of _foxes bell_.

=Description=—Foxglove is a biennial or perennial, the leaves of which
ought to be taken from the plant while in full flower. The lower
leaves are ovate with the lamina running down into a long stalk; those
of the stem become gradually narrower, passing into ovate-lanceolate
with a short broadly-winged stalk, or are sessile. All have the margin
crenate, crenate-dentate, or sub-serrate, are more or less softly
pubescent or nearly glabrous on the upper side, much paler and densely
pubescent on the under, which is marked with a prominent network of
veins. The principal veins diverge at a very acute angle from the
midrib, which is thick and fleshy. The lower leaves are often a foot or
more long, by 5 to 6 inches broad; those of the stem are smaller.

When magnified, the tip of each crenature or serrature of the leaf is
seen to be provided with a small, shining, wart-like gland. The hairs
of the lower surface are simple, and composed of jointed cells which
flatten in drying; those of the upper surface are shorter.

In preparing foxglove for medicinal use, it is the custom of some
druggists to remove the whole of the petiole and the thicker part
of the midrib, retaining only the thin lamina, which is dried with
a gentle heat.[1724] The fresh leaf has when bruised an unpleasant
herbaceous smell, which in drying becomes agreeable and tea-like. The
dried leaf has a very bitter taste.

=Chemical Composition=—Since the beginning of the present century,
numerous attempts have been made to prepare the active principle of
foxglove, and the name _Digitalin_ has been successively bestowed on
widely different substances.

Among the investigators engaged in these researches, we may point out
Walz (1846-1858), Kosmann (1845-46, 1860), Homolle partly with Quévenne
(1845-61), Nativelle (1872), and especially Schmiedeberg (1874).[1725]
The latter has prepared a new, well-defined, crystallizable principle,
_Digitoxin_, from Digitalis. He exhausted with water the leaves
previously dried and powdered, and then extracted them repeatedly with
dilute alcohol, 50 per cent.; the tincture thus obtained was then mixed
with basic acetate of lead as long as it produced a precipitate. The
latter being separated, the filtered liquid was concentrated and the
deposit now formed, after some days, removed from the aqueous liquid.
It was then washed with a dilute solution of carbonate of sodium, by
which a yellow matter (_chrysophan_?) was partly removed. The substance
was then dried, and yielded to chloroform a brownish mass, which
after the chloroform had been driven off, was purified by benzin.
This liquid dissolved the remainder of the yellow or orange matter,
and a little fat, leaving crude digitoxin, which is to be purified by
recrystallization from warm alcohol, 80 per cent., adding a little
charcoal. This purification still yields yellowish crystals, which
ought to be washed again with carbonate of sodium, ether or benzin, and
then recrystallized from warm absolute alcohol, containing a little
chloroform. This process, however, will only afford colourless crystals
provided it be so performed as to cause the separation of digitoxin on
account of the cooling of the solution, not by the evaporation of the
solvent. If the liquid is instead allowed to evaporate it will soon
assume a darker coloration. In the way just pointed out, perfectly
colourless scales or needle-shaped crystals of pure digitoxin are at
length formed, the yield being not more considerable than about _one_
part from 10,000 of dried leaves.

[1723] Prior, _Popular Names of British Plants_, ed. 2. 1870. 84.

[1724] This method of preparing the leaf was directed in the London
Pharmacopœia of 1851, but it had long been in use. No particular
directions are given in the British Pharmacopœia.

[1725] For further particulars on Schmiedeberg’s very elaborate
researches, the reader may consult my abstract of them in _Pharm.
Journ._ v. (1875) 741.—F. A. F..

Digitoxin is insoluble in water, to which it does not even impart its
intensely bitter taste as displayed in the alcoholic solution. It is
likewise insoluble in benzin or bisulphide of carbon, very sparingly
soluble in ether, more abundantly so in chloroform, the latter liquid
however acting but very slowly on digitoxin. Its best solvent is
alcohol, either cold or warm. The composition of digitoxin answers to
the formula, C₃₁H₃₃O₇.

Digitoxin warmed with concentrated hydrochloric acid assumes a
yellow or greenish hue, the same which is commonly attributed to
commercial “digitalin.” Digitoxin is not a saccharogenous matter; in
alcoholic solution it is decomposed by dilute acids, and then affords
_Toxiresin_, an uncrystallizable, yellowish substance, which may easily
be separated on account of its ready solubility in ether; it appears
to be produced also if digitoxin is maintained for some time in the
state of fusion at about 240° C. Toxiresin proved to be a very powerful
poison, acting energetically on the heart and muscles of frogs. The
very specific action of foxglove is due—_not_ exclusively—to digitoxin;
it is so highly poisonous that Schmiedeberg thinks it not at all fit
for medicinal use, which might rather be confined to other constituents
of foxglove, as, for instance, to those obtained from the seeds under
the names of digitalin and digitaléin. The latter, however, are of more
difficult extraction than digitoxin.

The preparation of digitoxin is similar to that of _Nativelle’s_
crystallized “digitalin;” the former as well as paradigitogenin[1726]
are largely found in Nativelle’s digitalin.

[1726] A derivative of _digitoxin_ as extracted by Schmiedeberg from
the seeds of foxglove.

The _Digitalin of Nativelle_—The researches on digitalis of this
chemist, for which the Orfila prize of 6000 francs was awarded in
1872, have resulted in the extraction of a crystallized preparation
possessing active medicinal properties. It may be obtained by the
following process:—

The leaves, previously exhausted by water, are extracted by means of
alcohol, sp. gr. ·930. The tincture is concentrated until its weight is
equal to that of the leaves used, and then diluted by adding thrice its
weight of water. A pitch-like deposit is then formed; _digitaléin_ and
other substances remaining in solution. The deposit dried on blotting
paper is boiled with double its weight of alcohol, sp. gr. ·907; on
cooling, crystals are slowly deposited during some days. They should be
washed with a little diluted alcohol (·958) and dried: to purify them,
they should be first recrystallized from chloroform, and subsequently
from boiling alcohol sp. gr. ·828, some charcoal being used at the
same time. Digitalin is thus obtained in _colourless needle-shaped
crystals_. It assumes an intense emerald green colour when moistened
with hydrochloric acid, and has an extremely bitter taste. On the
animal economy, it displays all the peculiar effects of digitalis, the
dose of a milligramme taken by an adult person once or twice a day
occasioning somewhat alarming symptoms, but smaller doses exhibiting
the sedative power of the herb.

Another body occurring in foxglove is the crystallizable sugar called
_Inosite_, which was detected by Marmé in the leaves, as well as
in those of dandelion (p. 394). Pectic matters are also present in
foxglove leaves.

=Uses=—Foxglove is a very potent drug, having the effect of reducing
the frequency and force of the heart’s action, and hence is given in
special cases as a sedative; it is also employed as a diuretic.

=Adulteration=—The dried leaves of some other plants have occasionally
been supplied for those of foxglove. Such are the leaves of
_Verbascum_, which are easily recognized by their thick coat of
branched stellate hairs; of _Inula Conyza_ DC. and _I. Helenium_ L.,
which have the margin almost entire, and in the latter plant the veins
diverging nearly at a right angle from the midrib; in both plants the
under side of the leaf is less strongly reticulated than in foxglove.
But to avoid all chance of mistake, it is desirable that druggists
should purchase the _fresh flowering plant_, which cannot be confounded
with any other, and strip and dry the leaves for themselves.




ACANTHACEÆ.


HERBA ANDROGRAPHIDIS.

_Kariyát or Creyat._

=Botanical Origin=—_Andrographis[1727] paniculata_ Nees ab E.
(_Justicia Burm._), an annual herb, 1 to 2 feet high, common throughout
India, growing under the shade of trees. It is found likewise in
Ceylon and Java, and has been introduced into the West Indies. In some
districts of India it is cultivated.

[1727] _Andrographis_ from δνὴρ and γραϕὶς, in allusion to the
brush-like anther and filament.—Fig. in Bentley and Trimen’s _Med.
Plants_, part 23 (1877).

=History=—It is probable that in ancient Hindu medicine this plant
was administered indiscriminately with chiretta, which, with several
other species of _Ophelia_, is known in India by nearly the same
vernacular names. Ainslie asserts that it was a component of a famous
bitter tincture called by the Portuguese of India _Droga amara_; but
on consulting the authority he quotes[1728] we find that the bitter
employed in that medicine was _Calumba_. _Andrographis_ is known in
Bengal as _Mahā-tīta_, literally _king of bitters_, from the Sanskrit
tikta, “bitter,” a title of which it has been thought so far deserving
that it has been admitted to a place in the _Pharmacopœia of India_.

=Description=—The straight, knotty branch stems are obtusely
quadrangular, about ¼ of an inch thick at the base, of a dark green
colour and longitudinally furrowed. The leaves are opposite, petiolate,
lanceolate, entire, the largest ½ an inch or more wide and 3 inches
long. Their upper surface is dark green, the under somewhat lighter,
and as seen under a lens finely granular. The leaves are very thin,
brittle, and, like the stems, entirely glabrous.

In the well-dried specimen before us, for which we are indebted to
Dr. G. Bidie of Madras, flowers are wanting and only a few roots are
present. The latter are tapering and simple, emitting numerous thin
rootlets, greyish externally, woody and whitish within. The plant is
inodorous and has a persistent pure bitter taste.

=Chemical Composition=—The aqueous infusion of the herb exhibits a
slight acid reaction, and has an intensely bitter taste, which appears
due to an indifferent, non-basic principle, for the usual reagents do
not indicate the presence of an alkaloid. Tannic acid on the other hand
produces an abundant precipitate, a compound of itself with the bitter
principle. The infusion is but little altered by the salts of iron; it
contains a considerable quantity of chloride of sodium.

=Uses=—Employed as a pure bitter tonic like quassia, gentian, or
chiretta, with the last of which it is sometimes confounded.




SESAMEÆ.


OLEUM SESAMI.

_Sesamé Oil_, _Gingeli_, _Gingili_ or _Jinjili Oil_, _Til_ or _Teel
Oil_, _Benné Oil_; F. _Huile de Sésame_; G. _Sesamöl_.

=Botanical Origin=—_Sesamum indicum_ DC., an erect, pubescent annual
herb, 2 to 4 feet high,[1729] indigenous to India, but propagated by
cultivation throughout the warmer regions of the globe, and not now
found anywhere in the wild state. In Europe, _Sesamum_ is only grown in
some districts of Turkey and Greece, and on a small scale in Sicily and
in the islands of Malta and Gozo. It does not succeed well even in the
South of France.

[1728] Paolino da San Bartolomeo, _Voyage to the East Indies_
(1776-1789), translated from the German, Lond. 1800; pp. 14. 409.

[1729] Fig. in Bentley and Trimen’s _Med. Plants_, part 23 (1877).

=History=—Sesamé is a plant which we find on the authority of the most
ancient documents of Egyptian, Hebrew,[1730] Sanskrit, Greek, and Roman
literature, has been used by mankind for the sake of its oily seeds
from the earliest times. The Egyptian name _Semsemt_ already occurring
in the Papyrus Ebers, is still existing in the Coptic _Semsem_, the
Arabic _Simsim_, and the modern _Sesamum_. The Indian languages have
their own terms for it, the Hindustani _Til_, from the Sanskrit _Tila_,
being one of the best known.[1731] _Tila_ already occurs in the Vedic
literature. In the days of Pliny the oil was an export from Sind to
Europe by way of the Red Sea, precisely as the seeds are at the present
day.

During the middle ages the plant, then known as _Suseman_ or _Sempsen_,
was cultivated in Cyprus, Egypt and Sicily; the oil was an article of
import from Alexandria to Venice. Joachim Camerarius gave a good figure
of the plant in his “Hortus medicus et philosophicus” 1588 (tab. 44).
In modern times sesame oil gave way to that of olives, yet at present
it is an article which, if not so renowned, is at least of far greater
consumption.

=Production=—The plant comes to perfection within 3 or 4 months; its
capsule contains numerous flat seeds, which are about ²/₁₀10 of an
inch long by ¹/₂₀ thick, and weigh on an average ¹/₁₆ of a grain. To
collect them, the plant when mature is cut down, and stacked in heaps
for a few days, after which it is exposed to the sun during the day,
but collected again into heaps at night. By this process the capsules
gradually ripen and burst, and the seeds fall out.[1732]

The plant is found in several varieties affording respectively white,
yellowish, reddish, brown or black seeds. The dark seeds may be
deprived of a part of their colouring matter by washing, which is
sometimes done with a view to obtain a paler oil.[1733]

We obtained from yellowish seeds 56 per cent. of oil; on a large scale,
the yield varies with the variety of seed employed and the process of
pressing, from 45 to 50 per cent.

=Description=—The best kinds of sesamé oil have a mild agreeable taste,
a light yellowish colour, and scarcely any odour; but in these respects
the oil is liable to vary with the circumstances already mentioned. The
white seeds produced in Sind are reputed to yield the finest oil.

We prepared some oil by means of ether, and found it to have a sp. gr.
of 0·919 at 23° C.; it solidified at 5° C., becoming rather turbid at
some degrees above this temperature. Yet sesame oil is more fluid at
ordinary temperatures than ground-nut oil, and is less prone to change
by the influence of the air. It is in fact, when of fine quality, one
of the less alterable oils.

[1730] Isaiah xxviii. 27.

[1731] The word _Gingeli_ (or _Gergelim_), which Roxburgh remarks was
(as it is now) in common use among Europeans, derives from the Arabic
_chulchulân_, denoting sesame seed in its husks before being reaped
(Dr. Rice). The word _Benné_ is, we believe, of West African origin,
and has no connection with _Ben_, the name of _Moringa_.

[1732] For further particulars see Buchanan, _Journey from Madras
through Mysore, etc._ i. (1807) 95. and ii. 224.

[1733] This curious process is described in the _Reports of Juries_,
_Madras Exhibition_, 1856, p. 31.—That the colouring matter of
the seeds is actually soluble in water is confirmed by Lépine of
Pondicherry as we have learnt from his manuscript notes presented to
the Musée des Produits des Colonies de France at Paris. The seeds may
even be used as a dye.

=Chemical Composition=—The oil is a mixture of olein, stearin and other
compounds of glycerin with acids of the fatty series. We prepared with
it in the usual way a lead plaster, and treated the latter with ether
in order to remove the oleate of lead. The solution was then decomposed
by sulphuretted hydrogen, evaporated and exposed to hyponitric vapours.
By this process we obtained 72·6 per cent. of _Elaïdic Acid_. The
specimen of sesamé oil prepared by ourselves consequently contained
76·0 per cent. of olein, inasmuch as it must be supposed to be present
in the form of triolein. In commercial oils the amount of olein is
certainly not constant.

As to the solid part of the oil, we succeeded in removing fatty acids,
freely melting, after repeated crystallizations, at 67° C., which may
consist of stearic acid mixed with one or more of the allied homologous
acids, as palmitic and myristic. By precipitating with acetate of
magnesium, as proposed by Heintz, we finally isolated acids melting at
52·5 to 53°, 62 to 63°, and 69·2° C., which correspond to myristic,
palmitic and stearic acids.

The small proportion of solid matter which separates from the oil on
congelation cannot be removed by pressure, for even at many degrees
below the freezing point it remains as a soft magma. In this respect
sesamé oil differs from that of olive.

Sesamé oil contains an extremely small quantity of a substance, perhaps
resinoid, which has not yet been isolated. It may be obtained in
solution by repeatedly shaking 5 volumes of the oil with one of glacial
acetic acid. If a cold mixture of equal weights of sulphuric and
nitric acids is added in like volume, the acetic solution acquires a
greenish yellow hue. The same experiment being made with spirit of wine
substituted for acetic acid, the mixture assumes a blue colour, quickly
changing to greenish yellow. The oil itself being gently shaken with
sulphuric and nitric acids, takes a fine green hue, as shown in 1852 by
Behrens, who at the same time pointed out that no other oil exhibits
this reaction. It takes place even with the bleached and perfectly
colourless oil. Sesamé oil added to other oils, if to a larger extent
than 10 per cent., may be recognised by this test. The reaction ought
to be observed with small quantities, say 1 gramme of the oil and 1
gramme of the acid mixture, previously cooled.

=Commerce=—The commercial importance of Sesamé may be at once
illustrated by the fact that France imported in 1870, 83 millions; in
1871, 57½ millions; and 1872, 50 millions of kilogrammes (984,693 cwt.)
of the seed.[1734]

The quantity shipped from British India in the year 1871-72 was 565,854
cwt., of which France took no less than 495,414 cwt.[1735] The imports
of the seed into the United Kingdom in 1870 were to the value of only
about £13,000.

Sesamé is extensively produced in Corea and in the Chinese island of
Formosa, which in 1869 exported the exceptionally large quantity of
46,000 peculs[1736] (1 pecul = 133 lb.). Zanzibar and Mozambique also
furnish considerable quantities of sesamé, whilst on the West Coast of
Africa the staple oil-seed is Ground-nut (_Arachis hypogæa_ L. p. 186).
The chief place for the manufacture of sesamé oil is Marseilles.

[1734] _Documents Statistiques réunis par l’Administration des Douanes
sur le commerce de la France_, année 1872.

[1735] _Statement of the Trade and Navigation of British India with
Foreign Countries_, Calcutta, 1872. 62.

[1736] _Reports on Trade at the Treaty Ports in China for 1870_,
Shanghai, 1871. 81.

=Uses=—Good sesamé oil might be employed without disadvantage for all
the purposes for which olive oil is used.[1737] As its congealing point
is some degrees below that of olive oil, it is even more fitted for
cool climates. Sesamé seeds are largely consumed as food both in India
and Tropical Africa. The foliage of the plant abounds in mucilage, and
in the United States is sometimes used in the form of poultice.




LABIATÆ.


FLORES LAVANDULÆ.

_Lavender Flowers_; F. _Fleurs de Lavande_; G. _Lavendelblumen_.

=Botanical Origin=—_Lavandula vera_ DC., a shrubby plant growing in
the wild state from 1 to 2 feet high, but attaining 3 feet or more
under cultivation. It is indigenous to the mountainous regions of the
countries bordering the western half of the Mediterranean basin. Thus
it occurs in Eastern Spain, Southern France (extending northward to
Lyons and Dauphiny), in Upper Italy, Corsica, Calabria and Northern
Africa,—on the outside of the olive region.[1738] In cultivation it
grows very well in the open air throughout the greater part of Germany
and as far north as Norway and Livonia; the northern plant would even
appear to be more fragrant, according to Schübeler.[1739]

=History=—There has been much learned investigation in order to
identify lavender in the writings of the classical authors, but the
result has not been satisfactory, and no allusion has been found which
unquestionably refers either to _L. vera_ or to _L. Spica_,[1740]
whereas _L. Stœchas_ was perfectly familiar to the ancients.

The earliest mention of lavender that we have observed, occurs in the
writings of the abbess Hildegard,[1741] who lived near Bingen on the
Rhine during the 12th century, and who in a chapter _De Lavendula_
alludes to the strong odour and many virtues of the plant. In a poem
of the school of Salerno entitled _Flos Medicinæ_[1742] occur the
following lines:—

    “Salvia, castoreum, _lavendula_, primula veris,
     Nasturtium, athanas hæc sanant paralytica membra.”

In 1387 cushions of satin were made for King Charles VI. of France, to
be stuffed with “_lavende_.”[1743] Its use was also popular at an early
period in the British isles, for we find “_Llafant_” or “_Llafanllys_”
mentioned among the remedies of the “Physicians of Myddvai.”[1744]
And in Walton’s “Description of an inn,” about the year 1680 to 1690,
we find the walls stuck round with ballads, where the sheets smelt of
_lavender_....[1745]

[1737] For pharmaceutical uses, the larger proportion of olein and
consequent lesser tendency to solidify, should be remembered.

[1738] On Mont Ventoux near Avignon, the region of _Lavandula vera_ is
comprised, according to Martins, between 1500 and 4500 feet above the
sea-level.—_Ann. des Sc. Nat._, Bot. x. (1838) 145. 149.

[1739] _Pflanzenwelt Norwegens_, Christiania (1873-1875) 26O.

[1740] F. de Gingins-Lassaraz, _Hist. des Lavandes_, Genève et Paris,
1826.

[1741] _Opera Omnia_, accurante J. P. Migne, Paris, 1855. 1143.

[1742] S. de Renzi, _Collectio Salernitana_, Napoli, i. 417-516.

[1743] Douët d’Arcq, _Comptes de l’Argenterie des rois de France_, ii.
(1874) 148.

[1744] _Meddygon Myddfai_ (see Appendix) 287.

[1745] Macaulay, _Hist. of England_, i. ch. 3, Inns.

Lavender was well known to the botanist of the 16th century.

=Description=—The flowers of Common Lavender are produced in a lax
terminal spike, supported on a long naked stalk. They are arranged
in 6 to 10 whorls (verticillasters), the lowest being generally far
remote from those above it. A whorl consists of two cymes, each having,
when fully developed, about three flowers, below which is a rhomboidal
acuminate bract, as well as several narrow smaller bracts belonging to
the particular flowers. The calyx is tubular, contracted towards the
mouth, marked with 13 nerves and 5-toothed, the posterior tooth much
larger than the others. The corolla of a violet colour is tubular,
two-lipped, the upper lip with two, the lower with three lobes. Both
corolla and calyx, as well as the leaves and stalks, are clothed with
a dense tomentum of stellate hairs, amongst which minute shining
oil-glands can be seen by the aid of a lens.

The flowers emit when rubbed a delightful fragrance, and have a
pleasant aromatic taste. The leaves of the plant are oblong linear, or
lanceolate, revolute at the margin and very hoary when young.

For pharmaceutical use or as a perfume, lavender flowers are stripped
from the stalks and dried by a gentle heat. They are but seldom kept in
the shops, being grown almost entirely for the sake of their essential
oil.

=Production of Essential Oil=—Lavender is cultivated in the parishes
of Mitcham, Carshalton and Beddington and a few adjoining localities,
all in Surrey, to the extent of about 300 acres. It is also grown at
Market Deeping in Lincolnshire; also at Hitchin in Hertfordshire, where
lavender was apparently cultivated as early as the year 1568.[1746]

At the latter place there were in 1871 about 50 acres so cropped.

The plants which are of a small size, and grown in rows in dry open
fields, flower in July and August. The flowers are usually cut with the
stalks of full length, tied up in mats, and carried to the distillery
there to await distillation. This is performed in the same large stills
that are used for peppermint. The flowers are commonly distilled with
the stalks as gathered, and either fresh, or in a more or less dry
state. A few cultivators distill only the flowering heads, thereby
obtaining a superior product. Still more rarely, the flowers are
stripped from the stalks, and the latter rejected _in toto_.[1747]
According to the careful experiments of Bell,[1748] the oil made
in this last method is of exceedingly fine quality. The produce he
obtained in 1846 was 26½ ounces per 100 lb. of flowers, entirely
freed from stalks; in 1847, 25½ ounces; and in 1848, 20 ounces: the
quantities of flowers used in the respective years were 417, 633,
and 923 lb. Oil distilled from the stalks alone was found to have a
peculiar rank odour. In the distillation of lavender, it is said that
the oil which comes over in the earlier part of the operation is of
superior flavour.

[1746] Perhs, _Proc. American Pharm. Association_, 1876. 819.

[1747] For more particulars see the interesting account of Holmes,
_Pharm. Journ._ viii. (1877) 301. The author describes also the disease
which is affecting the lavender since about the year 1860.

[1748] _Pharm. Journ._ viii. (1849) 276.

We have no accurate data as to the produce of oil obtained in the
ordinary way, but it is universally stated to vary extremely with the
season. Warren[1749] gives it as 10 to 12 lb., and in an exceptional
case as much as 24 lb. from the acre of ground under cultivation. At
Hitchin,[1750] the yield would appear to approximate to the last named
quantity. The experiments performed in Bell’s laboratory as detailed
above, show that the flowers deprived of stalks afforded on an average
exactly 1½ per cent. of essential oil.

Oil of _Lavandula vera_ is distilled in Piedmont, and in the
mountainous parts of the South of France, as in the villages about Mont
Ventoux near Avignon, and in those some leagues west of Montpellier
(St. Guilhen-le-désert, Montarnaud and St. Jean de Fos)—in all cases
from the wild plant. This foreign oil is offered in commerce of several
qualities, the highest of which commands scarcely one-sixth the price
of the oil produced at Mitcham.[1751] The cheaper sorts at least are
obtained by distilling the _entire plant_.

=Chemical Composition=—The only constituent of lavender flowers that
has attracted the attention of chemists is the essential oil (_Oleum
Lavandulæ_). It is a pale yellow, mobile liquid, varying in sp. gr.
from 0·87 to 0·94 (Zeller), having a very agreeable odour of the
flowers and a strong aromatic taste. The oil distilled at Mitcham
(1871) we find to rotate the plane of polarization 4·2° to the left, in
a column of 50 mm.

Oil of lavender seems to be a mixture in variable proportions of
oxygenated oils and stearoptene, the latter being identical, according
to Dumas, with common camphor. In some samples it is said to exist to
the extent of one-half, and to be sometimes deposited from the oil in
cold weather; we have not however been able to ascertain this fact.
The oil according to Lallemand (1859) appears also to contain compound
ethers.

=Commerce=—Dried lavender flowers are the object of some trade in the
south of Europe. According to the official _Tableau général du Commerce
de la France_, Lavender and Orange Flowers (which are not separated)
were exported in 1870 to the extent of 110,958 kilo. (244,741
lb.),—chiefly to the Barbary States, Turkey and America. There are no
data to show the amount of oil of lavender imported into England.

=Uses=—Lavender flowers are not prescribed in modern English medicine.
The volatile oil has the stimulant properties common to bodies of the
same class and is much used as a perfume.

[1749] _Pharm. Journ._ vi. (1865) 257.

[1750] _Ibid._ i. (1860) 278. The statement is that an acre of land
yields “_about 6 Winchester quarts_” of oil.—One Winchester quart = 282
litres.

[1751] The Mitcham oil fetches 30_s._ to 60_s._ per lb., according to
the season.

Other Species of Lavender.

1. _Lavandula Spica_ DC. is a plant having a very close resemblance
to _L. vera_, of which Linnæus considered it a variety, though its
distinctness is now admitted. It occurs over much of the area of
_L. vera_, but does not extend so far north, nor is it found in
such elevated situations, or beyond the limit of the olive. It is in
fact a more southern plant and more susceptible to cold, so that it
cannot be cultivated in the open soil in Britain except in sheltered
positions. In Languedoc and Provence, it is the common species from the
sea-level up to about 2000 feet, where it is met by the more hardy _L.
vera_.[1752]

_Lavandula Spica_ is distilled in the south of France, the flowering
wild plant in its entire state being used. The essential oil, which is
termed in French _Essence d’Aspic_, is known to English druggists as
_Oleum Lavandulæ spicæ_, _Oleum Spicæ_, or _Oil of Spike_. It resembles
true oil of lavender, but compared with that distilled in England it
has a much less delicate fragrance. This however may depend upon the
frequent adulteration, for we find that flowers of the two plants (_L.
vera_ and _L. Spica_) grown side by side in an English garden, are
hardly distinguishable in fragrance. Porta already even, in speaking
of the oil of lavender flowers, stated:[1753] “e _spica fragrantior_
excipitur, ut illud quod ex Gallia provenit....”—Lallemand (1859)
isolated from oil of spike a camphor which he believes to be identical
with common camphor.

Oil of Spike is used in porcelain painting and in veterinary medicine.

2. _Lavandula Stœchas_ L.—This plant was well known to the ancients;
Dioscorides remarks that it gives a name to the Stœchades, the modern
isles of Hières near Toulon, where the plant still abounds. It has a
wider range than the two species of _Lavandula_ already described, for
it is found in the Canaries and in Portugal, and eastward throughout
the Mediterranean region to Constantinople and Asia Minor. It may at
once be known from the other lavenders by its flower-spike being on a
_short_ stalk, and terminating in 2 or 3 conspicuous purple bracts.

The flowers, called _Flores Stœchados_ or _Stœchas arabica_,[1754] were
formerly kept in the shops, and had a place in the London Pharmacopœia
down to 1746. We are not aware that they are, or ever were distilled
for essential oil, though they are stated to be the source of _True Oil
of Spike_.[1755]


HERBA MENTHÆ VIRIDIS.

_Spearmint._

=Botanical Origin=—_Mentha viridis_ L. is a fragrant perennial plant,
chiefly known in Europe, Asia and North America, as the Common Mint
of gardens, and only found apparently wild in countries where it has
long been cultivated. It occurs occasionally in Britain under such
circumstances.[1756]

[1752] On the high land between Nice and Turbia, I have observed the
two species growing together, and that _L. vera_ is in flower two or
three weeks earlier than _L. Spica_.—D. H.

[1753] _De distillatione_, Romæ, 1608. 87.

[1754] The incorrectness of the term _Arabica_ is noticed by Pomet. How
it came to be applied we know not.

[1755] Pereira, _Elem. of Mat. Med._ ii. (1850) 1368.—Nor do we know
if _L. lanata_ Boiss., a very fragrant species closely allied to _L.
Spica_ DC., and a native of Spain, is distilled in that country.

[1756] Bentham, _Handbook of the British Flora_, 1858. 413.—Parkinson
(1640) remarks of _Speare Mint_ that it is “onely found planted in
gardens with us.”

_Mentha viridis_ is regarded by Bentham as not improbably a variety
of _M. silvestris_ L., perpetuated through its ready propagation
by suckers. J. G. Baker remarks, that while these two plants are
sufficiently distinct as found in England, yet continental forms occur
which bridge over their differences.[1757]

=History=—Mint is mentioned in all early mediæval lists of plants, and
was certainly cultivated in the convent gardens of the 9th century.
Turner, who has been called “the father of English botany,” states in
his _Herball_[1758] that the garden mint of his time was also called
“_Spere Mynte_.” We find spearmint also described by Gerarde who terms
it _Mentha Romana_ vel _Sarracenica_, or _Common Garden Mint_, but his
statement that the leaves are _white_, _soft_, and _hairy_ does not
well apply to the plant as now found in cultivation.

=Description=—Spearmint has a perennial rootstock which throws out
long runners. Its stem 2 to 3 feet high is erect, when luxuriant
branched below with short erecto-patent branches, firm, quadrangular,
naked or slightly hairy beneath the nodes, often brightly tinged with
purple. Leaves sessile or the lower slightly stalked, lanceolate or
ovate-lanceolate, rounded or even cordate at the base, dark green and
glabrous above, paler and prominently veined with green or purple
beneath, rather thickly glandular, but either quite naked or hairy only
on the midrib and principal veins, the point narrowed out and acute,
the teeth sharp but neither very close nor deep, the lowest leaves
measuring about 1 inch across by 3 or 4 inches long. Inflorescence
a panicled arrangement of spikes, of which the main one is 3 or 4
inches long by ⅜ inch wide, the lowest whorls sometimes ½ an inch from
each other and the lowest bracts leafy. Bracteoles linear-subulate,
equalling or exceeding the expanded flowers, smooth or slightly
ciliated. Pedicels about ¾ line long, purplish glandular, but never
hairy. Calyx also often purplish, the tube campanulato-cylindrical,
⅜ line long, the teeth lanceolate-subulate, equalling the tube, the
flower part of which is naked, but the teeth and often the upper
part clothed more or less densely with erecto-patent hairs. Corolla
reddish-purple, about twice as long as the calyx, naked both within and
without. Not smooth.

The plant varies slightly in the shape of its leaves, elongation of
spike and hairiness of calyx. The entire plant emits a most fragrant
odour when rubbed, and has a pungent aromatic taste.

=Production=—Spearmint is grown in kitchen gardens, and more largely in
market gardens. A few acres are under cultivation with it at Mitcham,
chiefly for the sake of the herb, which is sold mostly in a dried state.

The cultivation of spearmint is carried on in the United States in
precisely the same manner as that of peppermint, but on a much smaller
scale. Mr. H. G. Hotchkiss of Lyons, Wayne County, State of New York,
has informed us that his manufacture of the essential oil amounted in
1870 to 1162 lb. The plant he employs appears from the specimen with
which he has favoured us, to be identical with the spearmint of English
gardens, and is not the Curled Mint (_Mentha crispa_) of Germany.

[1757] Seemann’s _Journal of Botany_, Aug. 1865. p. 239. We borrow Mr.
Baker’s careful description of _Mentha viridis_.

[1758] Part 2. (1568) 54.

=Chemical Composition=—Spearmint yields an essential oil (_Oleum
Menthæ viridis_) in which reside the medicinal virtues of the plant.
Kane,[1759] who examined it, gives its sp. gr. as 0·914, and its
boiling point as 160° C. The oil yielded him a considerable amount
of stearoptene. Gladstone[1760] found spearmint oil to contain a
hydrocarbon almost identical with oil of turpentine in odour and other
physical properties, mixed with an oxidized oil to which is due the
peculiar smell of the plant. The latter oil boils at 225° C.; its sp.
gr. is 0·951, and it was found to be isomeric with carvol, C₁₀H₁₄O.
According to our experiments the oil, distilled from Curled Mint grown
in Germany, deviates the plane of polarization 37°·4 to the left when
examined in a column of 100 millimetres. We prepared from it the
crystallized compound (C₁₀H₁₄0)₂SH₂, and isolated from it the liquid
C₁₀H₁₄O, which differs from carvol (see Fructus Carui, page 306) by its
levogyrate power.[1761]

=Uses=—Spearmint is used in the form of essential oil and distilled
water, precisely in the same manner as peppermint In the United States
the oil is also employed by confectioners and the manufacturers of
perfumed soap.

=Substitutes=—Oil of spearmint is now rarely distilled in England, its
high cost[1762] causing it to be nearly unsaleable. The cheaper foreign
oil is offered in price-currents as of two kinds, namely _American_ and
_German_. Of the first we have already spoken: the second, termed in
German _Krauseminzöl_, is the produce of _Mentha aquatica_ L. var. γ
_crispa_ Bentham, a plant cultivated in Northern Germany. Its oil seems
to agree with the oil of spearmint.


HERBA MENTHÆ PIPERITÆ.

_Peppermint_; F. _Menthe poivrée_; G. _Pfefferminze_.

=Botanical Origin=—_Mentha piperita_ Hudson (non Linn.), an erect
usually glabrous perennial, much resembling the Common Spearmint of the
gardens, but differing from it in having the leaves all stalked, the
flowers larger, the upper whorls of flowers somewhat crowded together,
and the lower separate. In the opinion of Bentham it is possibly a mere
variety of _M. hirsuta_ L., with which it can be connected by numerous
intermediate forms.

Peppermint rapidly propagates itself by runners, and is now found in
wet places in several parts of England, as well as on the Continent. It
is cultivated on the large scale in England, France, Germany, and North
America.

=History=—_Mentha piperita_ was first observed in Hertfordshire by
Dr. Eales, and communicated to Ray, who in the second edition of his
_Synopsis Stirpium Britannicarum_, 1696, noticed it under the name
of _Mentha spicis brevioribus et habitioribus, foliis Menthæ fuscæ,
sapore fervido piperis_; and in his _Historia Plantarum_[1763] as
“_Mentha palustris_ ... _Peper-Mint_.”[1764] Dale, who found the plant
in the adjoining county of Essex, states[1765] that it is esteemed a
specific in renal and vesical calculus; and Ray, in the third edition
of his _Synopsis_, declares it superior to all other mints as a remedy
for weakness of the stomach and for diarrhœa. Peppermint was admitted
to the London Pharmacopœia in 1721, under the designation of _Mentha
piperitis sapore_.

[1759] _Philosophical Magazine_, xiii. (1838) 444.

[1760] _Journ. of Chemical Society_, ii. (1854) 11.

[1761] Flückiger, _Pharm. Journ._ vii. (1876) 75.

[1762] Price from 1824 to 1839, 40_s._ to 48_s._ per lb.

[1763] Tomus iii. (1704) 284.

[1764] I have examined the original specimen still preserved among
Ray’s plants in the British Museum and find it to agree perfectly with
the plant now in cultivation.—D. H.

[1765] _Pharmacologiæ Supplementum_, Lond. 1705. 117.

The cultivation of peppermint at Mitcham in Surrey dates from about
1750,[1766] at which period only a few acres of ground were there
devoted to medicinal plants. At the end of the last century, above 100
acres were cropped with peppermint. But so late as 1805 there were no
stills at Mitcham, and the herb had to be carried to London for the
extraction of the oil. Of late years the cultivation has diminished in
extent, by reason of the increased value of land and the competition of
foreign oil of peppermint.

On the Continent Mentha Piperitis was grown as early as 1771 at
Utrecht; Gaubius[1767] appears to have been the first to notice
“_Camphora Europæa Menthæ Piperitidis_,” i.e. Menthol (see page 483).

In Germany peppermint became practically known in the latter half of
the last century, especially through the recommendation of Knigge.[1768]

=Description=—The rootstock of peppermint is perennial, throwing out
runners. The stem is erect, 3 to 4 feet high, when luxuriant somewhat
branched below with erecto-patent branches, firm, quadrangular,
slightly hairy, often tinged with purple. Leaves all stalked, the
stalks of the lower ½ to ¾ of an inch long, naked or nearly so, the
leaf lanceolate, narrowed or rather rounded towards the base, the
point narrowed out and acute, the lowest 2 to 3 inches long by about
¾ of an inch broad, naked and dull green above, paler and glandular
all over, but only slightly hairy upon the veins beneath; the teeth
sharp, fine, and erecto-patent. Inflorescence in a loose lanceolate
or acutely conical spike, 2 to 3 inches long by about ¾ of an inch
broad at the base, the lowest whorls separate, and usually the lowest
bracts leaf-like. Bracteoles lanceolate-acuminate, about equalling
the expanded flowers, slightly ciliated. Pedicels 1 to 1½ lines long,
purplish, glandular but not hairy. Calyx often purplish, the tube about
1 line long and the teeth ½ a line, the tube campanulate-cylindrical,
purplish, not hairy, but dotted over with prominent glands; the teeth
lanceolate subulate, furnished with short erecto-patent hairs. Corolla
reddish-purple about twice as long as the calyx, naked both within and
without. Nut smooth[1769] (_rugose_, according to our observation). The
odour and taste are strongly aromatic.

In var. 2. _vulgaris_ of Sole, _M. piperita_ β. Smith, the plant is
more hairy, with the spikes broader and shorter, or even bluntly
capitate. colourless, pale yellow, or greenish liquid, of sp. gr.
varying from 0·84 to 0·92. We learn from information kindly supplied
by Messrs. Schimmel and Co., Leipzig, that the best peppermint grown
in Germany, carefully dried, affords from 1 to 1·25 per cent. of oil.
It has a strong and agreeable odour, with a powerful aromatic taste,
followed by a sensation of cold when air is drawn into the mouth. We
find that the Mitcham oil examined by polarized light in a column 50
mm. long, deviates from 14°·2 to 10°·7 to the left, American oil 4°·3.

=Chemical Composition=—The constituent for the sake of which peppermint
is cultivated is the essential oil, _Oleum Menthæ piperitæ_, a
coloureless, pale yellow or greenish liquid, of sp. gr. varying from
0·84 to 0·92. We learn from information kindly supplied by Messrs.
Schimmel and Co., Leipzig, that the best peppermint grown in
Germany, carefully dried from 1 to 1·25 per cent of oil. It has
a strong and agreeable odour, with a powerful aromatic taste, followed
by a sensation of cold when air is drawn into the mouth. We find that
the Mitcham oil examined by polarized light in a column 50 mm. long,
deviates from 14·2° to 10·7° to the left, American oil 4·2°.

[1766] Lysons, _Environs of London_, i. (1800) 254.

[1767] _Adversariorum varii argumenti liber unus_, Leidae, 1771. 99.

[1768] _De Menthâ Piperitide Commentatio_, Erlangæ, 1780.

[1769] This description is borrowed from Mr. Baker’s paper on the
English Mints, referred to at page 480, note 1.

When oil of peppermint is cooled to -4° C., it sometimes deposits
colourless hexagonal crystals of _Peppermint Camphor_, C₁₀H₁₉OH,
called also _Menthol_. We have never observed it, nor are we aware
that menthol has been noticed in America, but it is largely afforded
by eastern mints, and found in commerce under the name of _Chinese_
or _Japanese Oil of Peppermint_,[1770] either liquid, and easily
depositing the camphor, or also forming a crystalline mass impregnated
with the liquid oil.

Pure menthol has the exquisite odour and taste of peppermint; it
forms hexagonal crystals, melting at 42° C., and boiling at 212°
C. By distilling menthol with P₂O₅ it yields menthene, C₁₀H₁₈, a
levogyrate liquid, boiling at 163°, the peculiar odour of which reminds
of peppermint.[1771] The Chinese crystallized oil of peppermint has
sometimes a bitterish after-taste and an odour similar to that of
spearmint, but by recrystallization it assumes the pure flavour.

The liquid part of the oil of peppermint has not yet been thoroughly
investigated; it appears to consist chiefly of the compound C₁₀H₁₈O.
Upon the liquid portions depend the remarkable colorations which the
oil of peppermint is capable of assuming. If 50 to 70 drops of the
crude oil are shaken with one drop of nitric acid, sp. gr. about 1·2,
the mixture changes from faintly yellowish to brownish, and, after
an hour or two, exhibits a bluish, violet or greenish colour; in
reflected light, it appears reddish and not transparent. The colour
thus produced lasts a fortnight. We have thus examined the various
samples of peppermint oil at our command, and may state that the finest
among them assume the most beautiful coloration and fluorescence,
which, however, shows very appreciable differences. An inferior oil
of American origin was not coloured; and a very old sample of an
originally excellent English oil was likewise not coloured by the test.
Menthol is not altered when similarly treated.[1772] The nitric acid
test is not capable of revealing adulterations of peppermint oil, for
the coloration takes place with an oil to which a considerable quantity
of oil of turpentine has been added.

[1770] The Chinese oil is distilled at Canton, and was exported from
Canton in 1872 to the extent of 800 lbs.; it was valued at about 30s.
per lb.—See also Flückiger in _Pharm. Journ._ Oct. 14, 1871. 321. As to
Japan we are informed that there are large plantations of peppermint;
the oil “Hakano Abura” is exported from Hiogo and Osaka, but frequently
adulterated. Mr. Holmes informed me (1879) that he found the mother
plant coming nearest to _Mentha canadensis_.—F. A. F..

[1771] On Japanese Peppermint Camphor see Beckett and Alder Wright,
_Yearbook of Pharm._ 1875. 605.

[1772] _Pharm. Journ._ Feb. 25, 1871. 682.

Remarkable colorations of a different hue are also displayed by the
various kinds of oil of peppermint if other chemical agents are
mixed with it. Thus green or brownish tints are produced by means
of _anhydrous_ chloral; the oil becomes bluish or greenish or
rose-coloured if shaken with a concentrated solution of bisulphite
of sodium. It is worthy of note that oils of different origin, which
cannot be distinguished by means of nitric acid, exhibit totally
different colorations if mixed with either of the liquids just named,
or with vapour of bromine. This behaviour may be of some use in the
examination of commercial sorts of peppermint oil.

As to bisulphite of sodium, it yields a solid compound with certain
kinds of peppermint oil, which we have not yet examined.

=Production and Commerce=—In several parts of Europe, as well as in
the United States, peppermint is cultivated on the large scale as a
medicinal plant.

In England the culture is carried on in the neighbourhood of Mitcham
in Surrey, near Wisebeach in Cambridgeshire, Market Deeping in
Lincolnshire, and Hitchin in Hertfordshire.

At Mitcham in 1850 there were about 500 acres under cultivation; in
1864 only about 219 acres.[1773] At Market Deeping there were in 1871
about 150 acres cropped with peppermint. The usual produce in oil
may be reckoned at 8 to 12 lb. per acre. The fields of peppermint
at Mitcham are level, with a rich, friable soil, well manured and
naturally retentive of moisture. The ground is kept free from weeds,
and in other respects is carefully tilled. The crop is cut in August,
and the herb is usually allowed to dry on the ground before it is
consigned to the stills. These are of large size, holding 1000 to
2000 gallons, and heated by coal; each still is furnished with a
condensing worm of the usual character, which passes out into a small
iron cage secured by a padlock, in which stands the oil separator. The
distillation is conducted at the lowest possible temperature. The water
that comes over with the oil is not distilled with another lot of herb,
but is for the most part allowed to run away, a very little only being
reserved as a perquisite of the workmen. The produce is very variable,
and no facilities exist for estimating it with accuracy.[1774] It is
however stated that a ton of dried peppermint yields from 2½ to 3½
pounds of oil, which equals 0·11 to 0·15 per cent. But we have been
assured by a grower at Mitcham that the yield is as much as 6 pounds
from a ton, or 0·26 per cent.

At Mitcham and its neighbourhood two varieties of peppermint are at
present recognized, the one being known as _White Mint_, the other as
_Black Mint_, but the differences between the two are very slight. The
Black Mint has _purple_ stems; the White Mint, _green_ stems, and as
we have observed, leaves rather more coarsely serrated than those of
the Black. The Black Mint is more prolific in essential oil than the
White, and hence more generally cultivated; but the oil of the latter
is superior in delicacy of odour and commands a higher price. White
Mint is said to be principally grown for drying in bundles, or as it is
termed “_bunching_.”

[1773] _Pharm. Journ._ x. (1851) 297. 340; also Warren in _Pharm.
Journ._ vi. (1865) 257. To these papers and to personal inquiries we
are indebted for most of the particulars relating to peppermint culture
at Mitcham.

[1774] Only the larger growers have stills. These they let to smaller
cultivators who pay so much for distilling a charge, _i.e._ whatever
the still can be made to contain, without reference to weight. Hence
the dried herb is preferred to the fresh, as a larger quantity can be
distilled at one time.

Peppermint is grown on a vastly larger scale in America, the localities
where the cultivation is carried on being Southern Michigan, Western
New York, and Ohio. In Michigan where the plant was introduced in
1855, there were in 1858 about 2100 acres devoted to its growth, all
with the exception of about 100 acres being in the county of St.
Joseph, where there are about 100 distilleries. The average produce
of this district was estimated in 1858 at 15,000 lb.; but the yield
fluctuates enormously, and in the exceptionally fine season of 1855 it
was reckoned at 30,000 lb. We must suppose that it is sometimes much
larger, for we have been informed by Mr. H. G. Hotchkiss, of Lyons,
Wayne County, State of New York, one of the most well-known dealers, in
a letter under date Oct. 10, 1871, that the quantity sent out by him
in the previous year reached the enormous amount of 57,365 lb. It is
further stated by the official statistics of Hamburg for the year 1876
that this port received 25,840 lb. of peppermint oil from the United
States and 14,890 lb. from Great Britain.

From the statistics quoted by Stearns[1775] it would appear that the
produce of oil per acre is somewhat higher in America than in England,
but from various causes information on this head cannot be very
reliable.

Peppermint is cultivated at Sens in the department of the Yonne in
France[1776] and in Germany in the environs of Leipzig, where the
little town of Cölleda produces annually as much as 40,000 cwts. of the
herb.

The annual crop of the world is supposed to yield 90,000 lb. of
peppermint oil.[1777]

Peppermint oil varies greatly in commercial value, that of Mitcham
commanding twice or three times as high a price as the finest American.
Even the oil of Mitcham is by no means uniform in quality, certain
plots of ground affording a product of superior fragrance. A damp
situation or badly drained ground is well known to be unfavourable to
the quantity and quality of oil.

The presence of weeds among the peppermint is an important cause of
deterioration to the oil, and at Mitcham some growers give a gratuity
to their labourers to induce them to be careful in throwing out other
plants when cutting the herb for distillation. One grower of peppermint
known to us was compelled to abandon the cultivation, owing to the
enormous increase of _Mentha arvensis_ L. which could not be separated,
and which when distilled with the peppermint ruined the flavour of
the latter. In America great detriment is occasioned by the growth of
_Erigeron canadensis_ L. Newly cleared ground planted with peppermint
is liable to the intrusion of another plant of the order Compositæ,
_Erechtites hieracifolia_ Raf., which is also highly injurious to the
quality of the oil.[1778]

=Uses=—A watery or spirituous solution of oil of peppermint is a
grateful stimulant, and is a frequent adjunct to other medicines. Oil
of peppermint is extensively consumed for flavouring and cordials.

[1775] To whose paper _On the Peppermint Plantations of Michigan_ in
the _Proceedings of the Americ. Pharm. Assoc._ for 1858, we owe the
few particulars for which we can here afford space.—To be farther
consulted, same _Proceedings_, 1876. 828.

[1776] _Journ. de Pharm._ viii. (1868) 130.—Abstract from Roze, _La
Menthe poivrée, sa culture en France, ses produits, falsifications de
l’essence et moyens de les reconnaître_, Paris, 1868. 43 pages.

[1777] Todd, _Proceedings Am. Ph. Ass._ 1876, 828.

[1778] Maisch, _American Journ. of Pharm._ March 1870. 120.


HERBA PULEGII.

_Pennyroyal_[1779]; F. _Menthe pouliot_, _Pouliot vulgaire_; G. _Polei_.

=Botanical Origin=—_Mentha Pulegium_ L., a small perennial aromatic
plant, common throughout the south of Europe and extending northward
to Sweden, Denmark, England and Ireland, eastward to Asia Minor and
Persia, and southward to Abyssinia, Algeria, Madeira and Teneriffe. It
has been introduced into North[1780] and South America. For medicinal
use it is cultivated on a small scale.

=History=—Pennyroyal was in high repute among the ancients. Both
Dioscorides and Pliny describe its numerous virtues. In Northern
Europe it was also much esteemed, as may be inferred from the frequent
reference to it in the Anglo-Saxon and Welsh works on medicine.

Gerarde considered the plant to be “so exceedingly well known to all
our English nation” that it needed no description. In his time (_circa_
1590), it used to be collected on the commons round London, whence
it was brought in plenty to the London markets. At the present day
pennyroyal has fallen into neglect, and is not named in the British
Pharmacopœia of 1867.

=Description=—The plant has a low, decumbent, branching stem, which in
flowering rises to a height of about 6 inches. Its leaves, scarcely
an inch in length and often much less, are petiolate, ovate, blunt,
crenate at the margin, dotted with oil-glands above and below. The
flowers are arranged in a series of dense, globose whorls, extending
for a considerable distance up the stem. The whole plant is more or
less hairy. It has a strong fragrant odour, less agreeable to most
persons than that of peppermint or spearmint. Its taste, well perceived
in the distilled water, is highly aromatic.

=Chemical Composition=—The most important constituent of pennyroyal
is the essential oil, known in pharmacy as _Oleum Pulegii_, to which
is due the odour of the plant. It has been examined by Kane,[1781]
according to whom it has a sp. gr. of 0·927. Its boiling was found to
fluctuate between 183° and 188° C. The formula assigned to it by this
chemist is C₁₀H₁₆O. We ascertained that it contains no carvol (see page
481.)

=Production=—Pennyroyal is cultivated at Mitcham and is mostly sold
dried; occasionally the herb is distilled for essential oil. The oil
found in commerce is however chiefly French or German, and far less
costly than that produced in England.

=Uses=—The distilled water of pennyroyal is carminative and
antispasmodic, and is used in the same manner as peppermint water.

[1779] _Pennyroyal_, in old herbals _Puloil royal_ is derived from
_Puleium regium_, an old Latin name given from the supposed efficacy of
the plant in destroying fleas (Prior).

[1780] The native Pennyroyal is however a different plant, namely
_Hedeoma pulegioides_ Pers., figured in part 21 (1877) of Bentley and
Trimen’s _Med. Plants_.

[1781] _Phil. Mag._ xiii. (1838) 442.


HERBA THYMI VULGARIS.

_Garden Thyme_; F. _Thym vulgaire_; G. _Thymiankraut_.

=Botanical Origin=—_Thymus vulgaris_ L., a small, erect, woody shrub
reaching 8 to 10 inches in height, gregarious on sterile uncultivated
ground in Portugal, Spain, Southern France and Italy, and in the
mountainous parts of Greece. On Mont Ventoux near Avignon, it reaches
an elevation above the sea of 3700 ft. (Martins). It is commonly
cultivated in English kitchens as a sweet herb,[1782] and succeeds as
an annual even in Iceland.

=History=—We are not aware that thyme had any reputation in the
antiquity, nor do we know at what period it was first introduced in
northern countries. Garden thyme was commonly cultivated in England in
the 16th century, and was well figured and described by Gerarde. It is
even said to have been formerly grown on a large scale for medicinal
use in the neighbourhood of Deal and Sandwich in Kent.[1783] _Camphor
of Thyme_ was noticed by Neumann, apothecary to the Court at Berlin in
1725;[1784] it was called _Thymol_, and carefully examined in 1853 by
Lallemand, and recommended instead of phenol (carbolic acid) in 1868 by
Bouilhon, apothecary, and Paquet, M. D. of Lille.

=Description=—The plant produces thin, woody, branching stems, bearing
sessile, linear-lanceolate, or ovate-lanceolate leaves. These are
about ¼ of an inch long, revolute at the margin, more or less hoary,
especially on the under side, and dotted with shining oil-glands. The
small purple flowers are borne on round terminal heads, with sometimes
a few lower whorls. The entire wild plant has a greyish tint by reason
of a short white pubescence, yet as seen in gardens the plant is more
luxuriant, greener and far less tomentose. It is extremely fragrant
when rubbed, and has a pungent aromatic taste.

=Production of Essential Oil=—Though cultivated in gardens for culinary
use, common thyme is not grown in England on a large scale. Its
essential oil (_Oleum Thymi_), for which alone it is of interest to the
druggist, is distilled in the south of France. In the neighbourhood
of Nîmes, where we have observed the process, the entire plant is
used, and the distillation is carried on at two periods of the year,
namely in May and June when the plant is in flower, and again late
in the autumn. The oil has a deep, reddish-brown colour, but becomes
colourless though rather less fragrant by re-distillation. The two
sorts of oil, termed respectively _Huile rouge de Thym_ and _Huile
blanche de Thym_, are found in commerce. The yield is about 1 per cent.

Oil of thyme is frequently termed in English shops _Oil of Origanum_,
which it in no respect resembles, and which was never, so far as we
know, found in commerce.[1785]

[1782] In many of the references to thyme, _Wild Thyme_ (_Thymus
Serpyllum_ L.) is to be understood, and not the present species.

[1783] Booth in _Treasury of Botany_, ii. (1866) 1149.

[1784] _Phil. Trans._ No. 389.

[1785] For a note on _True Oil of Origanum_, see Hanbury, _Pharm.
Journ._ x. (1851) 324, also _Science Papers_, 1876, p. 46.

=Chemical Composition=—The only constituent of the herb that has
attracted any attention is the above-named essential oil. This
liquid by fractional distillation is resolved into two portions: the
first, more volatile and boiling below 180° C., is a mixture of two
hydrocarbons, _Cymene_, C₁₀H₁₄ (see page 333), and _Thymene_, C₁₀H₁₆,
the latter boiling at 165° C.

The second, named _Thymol_, C₁₀H₁₄O, which may also be extracted from
the crude oil by means of caustic lye, has been described in our
article _Fructus Ajowan_, at page 303. Commercial oil of thyme is said
to be sometimes fraudulently deprived of thymol by that treatment.

=Uses=—Oil of thyme is an efficient external stimulant, and is
sometimes employed as a liniment. Its chief consumption is in
veterinary medicine. Thymol has been proposed as a disinfectant in the
place of carbolic acid, in cases in which the odour of the latter is
objectionable. The herb is not used in modern English medicine, but is
often employed on the Continent.


HERBA ROSMARINI.

_Herba Anthos_; _Rosemary_; F. _Romarin_; G. _Rosmarin_.

=Botanical Origin=—_Rosmarinus officinalis_ L., an evergreen shrub,
attaining a height of 4 feet or more, abundant on dry rocky hills of
the Mediterranean region, from the Spanish peninsula[1786] to Greece
and Asia Minor. It generally prefers the neighbourhood of the sea,
but occurs even in the Sahara, where it is collected and conveyed by
caravans to Central Africa.[1787] It does not succeed well in Germany.

=History=—Rosemary[1788] is mentioned by Pliny, who ascribes to it
numerous virtues. It was also familiar to the Arab physicians of Spain,
one of whom, Ibn Baytar (13th cent.), states it to be an object of
trade among the vendors of aromatics.[1789] In the middle ages rosemary
was doubtless much esteemed, as may be inferred from the fact that it
was one of the plants which Charlemagne ordered to be grown on the
imperial farms.

It was probably in cultivation in Britain prior to the Norman Conquest,
as it is recommended for use in an Anglo-Saxon herbal of the 11th
century.[1790] In the “Physicians of Myddvai” a curious chapter[1791]
is devoted to the virtues of Rosemary, called “Ysbwynwydd, and Rosa
Marina in Latin.” The essential oil was distilled by Raymundus
Lullus[1792] about A.D. 1330. John Philip de Lignamine,[1793] a writer
of the 15th century, describes Rosemary as the usual condiment of
salted meats.

[1786] From Galicia in Spain, stems of Rosmarinus having 2½ inches in
diameter were to be seen at the Paris Exhibition, 1878.

[1787] Duveyrier, _Les Touaregs du Nord_, 1864. 187.

[1788] From _ros_ and _marinus_,—literally _marine dew_. Various
opinions have been held as to the allusion conveyed by the name.

[1789] Sontheimer’s translation, i. 73.

[1790] _Herbarium Apuleii_—_Leechdoms etc. of Early England_, i. (1864)
185.

[1791] _Meddygon Myddfai_ (see Appendix) p. 261. 292. 440.

[1792] Manget, _Bibliotheca chemica curiosa_, Genevæ, i. (1702) 829.

[1793] _Conservatorium Sanitatis_ (or also, according to Haller,
_Biblioth. botanica_, i. 237, _De conservatione sanitatis_, Bononiæ,
1475) cap. 81.

=Description=—Rosemary has sessile, linear, entire, opposite leaves
about an inch in length, revolute at the margin; they are of coriaceous
texture, green and glabrous above, densely tomentose and white beneath.
Examined under a lens, the tomentum both of the leaves and young shoots
is seen to consist of white stellate hairs; in that of the shoots which
is less dense, minute oil-glands are discernible. These glands are of
two kinds, large and small, and probably do not yield one and the same
oil. The flowers have a campanulate 2-lipped calyx, and a pale blue
and white corolla, the upper lip of which is emarginate and erect,
the lower 3-lobed with the central lobe concave and pendulous. The
whole plant has a very agreeable smell and a strong aromatic taste. It
flowers in the early spring.

=Production of Essential Oil=—Rosemary is cultivated on a very
small scale in English herb-gardens, and though a little oil has
been occasionally distilled from it, English oil of rosemary is an
article practically unknown in commerce. That with which the market
is supplied is produced in the south of France and on the contiguous
coasts of Italy. The plant, which is plentifully found wild, is
gathered in summer (not while in flower) and distilled, the operator
being sometimes an itinerant herbalist who carries his copper alembic
from place to place, erecting it where herbs are plentiful, and
where a stream of water enables him to cool a condenser of primitive
construction.

Oil of rosemary is also produced on a somewhat large scale in the
island of Lesina, south of Spalato in Dalmatia, whence it is exported
by way of Trieste, even to France and Italy, to the extent of 300 to
350 quintals annually.[1794]

Some of the French manufacturers of essences offer oil of rosemary at
a superior price as drawn _from the flowers_, by which we presume is
meant the _flowering tops_, for the separation of the actual flowers
would be impracticable on a large scale. The great bulk of the oil
found in commerce is however that distilled from the entire plant.

=Chemical Composition=—The peculiar odour of rosemary depends on the
essential oil, which is the only constituent of the plant that has
afforded matter for chemical research.

Lallemand (1859) by fractional distillation, resolved oil of rosemary
into two liquids,—the one a mobile hydrocarbon boiling at 165° C. and
turning the plane of polarization to the left; the other, boiling
between 200° and 210° C., deposits when exposed to a low temperature a
large quantity of camphor. Gladstone (1864) found the oil to consist
almost wholly of a hydrocarbon, C₁₀H₁₆. This, according to our
experiments, constitutes about ⁴/₅ of the oil; it deviates the plane of
polarization to the left, whereas a fraction boiling at 200° to 210°
C. deviates to the right. By warming the latter with nitric acid, we
observed the odour of common camphor, and may therefore infer that a
compound, C₁₀H₁₈O, is present in the oil under examination.

From Montgolfier’s investigations (1876) it would appear that the
stearoptene or camphor above alluded to is a mixture of a dextrogyrate
and a lævogyrate substance.

[1794] Unger, _Der Rosmarin und seine Verwendung in
Dalmatien—Sitzungsberichte der Wiener Akademie_, lvi. (1867) 587;
abstracted, with a few additions, in _Pharm. Journ._ ix. (1879) 618.

=Uses=—The flowering tops and dried leaves are kept by the herbalists,
but are not used in regular medicine. The volatile oil is employed as
an external stimulant in liniments, and also as a perfume. Rosemary is
popularly supposed to promote the growth of the hair.




PLANTAGINEÆ.


SEMEN ISPAGHULÆ.

_Ispaghúl Seeds_, _Spogel Seeds_.

=Botanical Origin=—_Plantago decumbens_ Forsk. (_P. Ispaghula_
Roxb.),[1795] a plant of variable aspect, from an inch to a foot in
height, erect or decumbent, with linear lanceolate leaves which may be
nearly glabrous, or covered with shaggy hairs. The flower-spikes differ
according to the luxuriance of the plant, being in some specimens
cylindrical and 1½ inches long, in others reduced to a globular
head. The plant has a wide range, occurring in the Canary Islands,
Egypt, Arabia, Beluchistan, Afghanistan, and North-western India.
Stewart[1796] says it is common in the Peshawar valley and Trans-Indus
generally up to 2000 feet; also on the plains and lower hills of the
Punjab, but that he has never seen it cultivated in the latter region.
It is said to be cultivated at Multan and Lahore, also in Bengal and
Mysore.

=History=—The seeds which are found in all the bazaars of India and
are held in great esteem, are generally designated by the Persian word
_Ispaghúl_; but they also bear the Arabic name _Bazre-qatúná_, under
which we find them mentioned by the Persian physician Alhervi[1797]
in the 10th century, and about the same period or a little later by
Avicenna.[1798] Several other Oriental writers are quoted by Ibn
Baytar[1799] as referring to a drug of the same name, which may
possibly have included the seeds of other species, as _Plantago
Psyllium_ L. and _P. Cynops_, having similar properties, and known to
have been used from an early period.

J. H. Linck, whom we mentioned in our article on Oleum Cajuputi (p.
278), described in 1719 the seed under notice, yet without knowing its
name; it further attracted the notice of Europeans towards the close of
the last century,[1800] and has been often prescribed as a demulcent in
dysentery and diarrhœa. It was admitted to the _Pharmacopœia of India_
of 1868.

[1795] After the examination of numerous specimens, we adopt the
course taken by Dr. Aitchison (_Catalogue of the Plants of the Punjab
and Sindh_, Lond. 1869) of uniting _P. Ispaghula_ to _P. decumbens_.
The union of species in this group may probably be carried still
further.—For a fig. see Bentley and Trimen, _Med. Plants_, part 21
(1877).

[1796] _Punjab Plants_, Lahore 1869. 174—also MS. note attached to
specimens in Herb. Kew.

[1797] _Liber Fundamentorum Pharmacologiæ_, ed. Seligmann, Vindobonæ,
1830. 40.

[1798] Lib. ii. tract. 2. c. 541. (Valgrisi edition, 1564. i. 357.)

[1799] Sontheimer’s transl. i. (1840) 132.

[1800] Fleming, _Catal. of Indian Med. Plants and Drugs_, Calcutta,
1810. 31.

=Description=—The seeds, like those of other species of _Plantago_, are
of boat-shaped form, the albumen being deeply furrowed on one side and
vaulted on the other. They are a little over ⅒ of an inch in length
and nearly half as broad, and so light that 100 weigh scarcely three
grains. Their colour is a light pinkish grey with an elongated brown
spot on the vaulted back, due to the embryo, which at this point is
in close contact with the translucent testa. From this brown spot the
thick radicle runs to the top of the seed. The hollow side of the seed
is also brown and partially covered with a thin white membrane.

The seeds are highly mucilaginous in the mouth, but have neither taste
nor odour. Those of the allied _P. Psyllium_ have nearly the same form,
but are shining and of a dark brown hue.

=Microscopic Structure=—This can be best investigated by immersing
the seed in benzol, as in this medium the mucilage is insoluble. When
thus examined, the whole surface is seen to consist of polyhedral
cells, separated by a very thin brown layer from the albumen, which
on the back of the seed is only 70 mkm. thick. The albumen is made up
of thick-walled cells, loaded with granules of matter which acquire
an orange hue on addition of iodine. The two cotyledons adhere in a
direction perpendicular to the bottom of the furrow; their tissue is
composed of thin-walled smaller cells, containing also albuminous
granules and drops of fatty oil.

If the seed is immersed in water, the cells composing the epidermis
instantly swell and elongate, and soon burst, leaving only fragments of
their walls. When examined under glycerin, the change is more gradual,
and the outer walls of the cells yielding the mucilage display a series
of thin layers, which slowly swell and disappear by the action of
water. The mucilage is consequently not contained within the cells, but
is formed of the secondary deposits on their walls, as in linseed and
quince pips.

=Chemical Composition=—Mucilage is so abundantly yielded by these
seeds, that one part of them with 20 parts of water forms a thick
tasteless jelly. On addition of a larger quantity of water and
filtering, but little mucilage passes, the greater part of it adhering
to the seeds. The mucilage separated by straining with pressure does
not redden litmus, is not affected by iodine, nor precipitated by
borax, alcohol or ferric chloride. The fat oil and albuminous matter of
the seed have not been examined.

=Uses=—A decoction of the seeds (1 p. to 70 p. of water) is employed in
India as a cooling, demulcent drink. The seeds powdered and mixed with
sugar, or made gelatinous with water, are sometimes given in chronic
diarrhœa.




POLYGONACEÆ.


RADIX RHEI.

_Rhubarb_; F. _Rhubarbe_; G. _Rhabarber_.

=Botanical Origin=—No competent observer, as far as we know, has ever
ascertained as an eye-witness the species of Rheum which affords the
commercial rhubarb. Rheum officinale, from which it seems, at least
partly, derived is the only species yielding a rootstock which agrees
with the drug.

_Rheum officinale_ Baillon is a perennial noble plant resembling the
Common Garden Rhubarb, but of larger size. It differs from the latter
in several particulars: the leaves spring from a distinct crown rising
some inches above the surface of the ground; they have a subcylindrical
petiole, which as well as the veins of the under side of the lamina is
covered with a pubescence of short erect hairs. The lamina, the outline
of which is orbicular, cordate at the base, is shortly 5-to 7-lobed,
with the lobes coarsely and irregularly dentate; it attains 4 to 4½
feet in length and rather more in breadth. The first leaves in spring
display before expanding the peculiar metallic red hue of copper.

The plant was discovered in South-eastern Tibet, where it is said to be
often cultivated for the sake of its medicinal root; but it is supposed
to grow in various parts of Western and North-western China, whence
the supplies of rhubarb are derived. It was obtained by the French
missionaries about the year 1867 for Dabry, French Consul at Hankow,
who transmitted specimens to Dr. Soubeiran of Paris. From one of these
which flowered at Montmorency in 1871, a botanical description was
drawn up by Baillon.[1801]

To what extent the rhubarb of commerce is derived from this plant is
not known. But that the latter may be a true source of the drug is
supported by the fact, that there is at least no important discrepancy
between it and the accounts and figures, scanty and imperfect though
they are, given by Chinese authors and the old Jesuit missionaries; and
still more by the agreement in structure which exists between its root
and the Asiatic rhubarb of commerce.

We have engaged in 1873 Mr. Rufus Usher at Bodicott (see below, p. 500)
to cultivate Rheum officinale, which is there admirably succeeding;
but it must be granted that as yet the root, notwithstanding the most
careful preparation in drying it, is far from displaying the rich
yellow of the commercial drug. It is most obviously marked on the other
hand with the characteristic ring of stellate markings, which we have
constantly observed in many roots of Rheum officinale cultivated by us
at Clapham Common near London, as well as at Strassburg or, by other
observers, at Paris.

_Rheum palmatum_ L., a species known as long as 1750, has always been
supposed to yield also rhubarb, and this has again been asserted by the
Russian Colonel Przewalski, who observed in 1872 and 1873 that plant
in the Alpine parts of Tangut round the Lake Kuku-nor, in the Chinese
province of Kansu, in 36°-38° North Lat.—Rheum palmatum has been
frequently cultivated in Russian Asia and in many parts of Europe since
the last century, but without producing a root agreeing with Chinese
rhubarb. Now, Przewalski states that from this species the drug under
notice is largely collected along the river Tetung-gol (or Datung-ho),
a tributary of the upper Hoang-ho, northward of the Kuku-nor. Specimens
of that root were largely brought to St. Petersburg by Przewalski, but
Dragendorff expressly points out in his _Jahresbericht_ for 1877 (p.
78) that it is _dissimilar_ to true rhubarb.

[1801] _Adansonia_, x. 246; _Association Française pour l’avancement
de la Science_, Comptes Rendus de la 1ʳᵉ Session, 1872. 514-529. pl.
x.—The figure which is reproduced in Lanessan’s French translation of
the _Pharmacographia_, ii. (Paris, 1878) 210, gives a good idea of the
highly ornamental character of Rheum officinale.

=History=[1802]—The Chinese appear to have been acquainted with the
properties of rhubarb from a period long anterior to the Christian
era, for the drug is treated of in the herbal called _Pen-king_,
which is attributed to the Emperor Shen-nung, the father of Chinese
agriculture and medicine, who reigned about 2700 B.C. The drug is named
there _Huang-liang_, yellow, excellent, and _Ta-huang_, the great
yellow.[1803] The latter name also occurs in the great Geography of
China, where it is stated that rhubarb was a tribute of the province
Si-ning-fu, eastward of Lake Kuku-nor,[1804] from about the 7th to the
10th centuries of our era.

As regards Western Asia and Europe, we find a root called ῤᾶ or ῤῆον,
mentioned by Dioscorides as brought from beyond the Bosphorus. The same
drug is alluded to in the fourth century by Ammianus Marcellinus,[1805]
who states that it takes its name from the river Rha (the modern
Volga), on whose banks it grows. Pliny describes a root termed
_Rhacoma_, which when pounded yielded a colour like that of wine but
inclining to saffron, and was brought from beyond Pontus.

The drug thus described is usually regarded as rhubarb, or at least
as the root of some species of _Rheum_, but whether produced in the
regions of the Euxine (Pontus), or merely received thence from remoter
countries, is a question that cannot be solved.

It is however certain that the name _Radix pontica_ or _Rha ponticum_,
used by Scribonius Largus[1806] and Celsus,[1807] was applied in
allusion to the region whence the drug was received. Lassen has shown
that trading caravans from Shensi in Northern China arrived at Bokhara
as early as the year 114 B.C. Goods thus transported might reach Europe
either by way of the Black Sea, or by conveyance down the Indus to
the ancient port of Barbarike. Vincent suggests[1808] that the _rha_
imported by the first route would naturally be termed _rha-ponticum_,
while that brought by the second might be called _rha-barbarum_.

We are not prepared to accept this plausible hypothesis. It receives no
support from the author of the Periplus of the Erythrean Sea (_circa_
A.D. 64), whose list of the exports of Barbarike[1809] does not include
rhubarb; nor is rhubarb named among the articles on which duty was
levied at the Roman custom-house of Alexandria (A.D. 176-180).[1810]

The terms _Rheum barbarum_ vel _barbaricum_ or _Reu barbarum_ occur in
the writings of Alexander Trallianus[1811] about the middle of the 6th
century, and in those of Benedictus Crispus,[1812] archbishop of Milan,
and Isidore[1813] of Seville, who both flourished in the 7th century.
Among the Arabian writers on medicine, the younger Mesue, in the early
part of the 11th century, mentions the rhubarb of China as superior to
the _Barbaric_ or Turkish.[1814] Constantinus Africanus[1815] about the
same period speaks of Indian and Pontic _Rheum_, the former of which he
declares to be preferable. In 1154 the celebrated Arabian geographer
Edrisi[1816] mentions rhubarb as a product of China, growing in the
mountains of Buthink—probably the environs of north-eastern Tibet near
Lake Tengri Nor (or Bathang in Western Szechuen?).

[1802] For further particulars see Flückiger, _Pharm. J._ vi. (1876)
861; also _Proc. Americ. Pharm. Assoc._ 1876. 130, with fig. showing
Rheum officinale grown in a poor soil.

[1803] Bretschneider, _Chinese Botanical Works_, Foochow, 1870. 2.

[1804] Flückiger, _l.c._

[1805] _Scriptores Historiæ Romanæ latini veteres_, ii. (1743) 511
(Amm. Marc. xxii. c. 8.)

[1806] _De Compositione Medicamentorum_, c. 167.

[1807] _De Medicinâ_. lib. v. c. 23.

[1808] Vincent, _Commerce and Navigation of the Ancients_, ii. (1807)
389.

[1809] _Ibid._, _op. cit._ ii. 390.

[1810] _Ibid._, _op. cit._ ii. 686.

[1811] Lib. viii. c. 3 (Haller’s edition).

[1812] Migne, _Patrologiæ Cursus_, lxxxix. 374.

[1813] Migne. _op. cit._, lxxxii. 628. The explanation given by Isidore
is this:—“_Reubarbarum_, sive _Reuponticum_: illud quod trans Danubium
in solo barbarico; istud quod circa Pontum colligitur, nominatum est.
_Reu_ autem _radix_ dicitur. _Reubarbarum_ ergo, quasi _radix barbara_.
_Reuponticum_ quasi _radix pontica_.” But Isidore was fond of such
derivations.

[1814] _Ravedsceni_, _Raved barbarum_, and _Raved Turchicum_ are the
terms used in the Latin translations we have consulted.

[1815] _De omnibus medico cognitu necessariis_, Basil. 1539. 354.

[1816] Translation of Jaubert, i. (Paris, 1836) 494.

Rhubarb in the 12th century was probably imported from India, as we
may infer from the tariff of duties levied at the port of Acon in
Syria, in which document[1817] it is enumerated along with many Indian
drugs. A similar list of A.D. 1271, relating to Barcelona, mentions
_Ruibarbo_.[1818] In a statute of the city of Pisa called the _Breve
Fundacariorum_, dating 1305, rhubarb (_ribarbari_) is classified with
commodities of the Levant and India.[1819]

The first and almost the only European who has visited the
rhubarb-yielding countries of China is the famous Venetian traveller,
Marco Polo,[1820] who speaking of the province of Tangut says—“ ... et
par toutes les montagnes de ces provinces se treuve le _reobarbe_ en
grant habondance. Et illec l’achatent les marchans et le portent par le
monde.”

A sketch of the history of rhubarb would be incomplete without some
reference to the various routes by which the drug has been conveyed
to Europe from the western provinces of the Chinese Empire, and which
have given rise to the familiar designations of _Russian_, _Turkey_ and
_China Rhubarb_.[1821]

[1817] _Assises de Jérusalem_ contained in the _Recueil des Historiens
des Croisades_, _Lois_, ii. (1843) 176.

[1818] Capmany, _Memorias de ... Barcelona_, i. (1779) 44.

[1819] Bonaini, _Statuti inediti della città di Pisa dal xii al xiv
secolo_, iii. (Firenze, 1857) 106. 115.

[1820] Pauthier, _Le Livre de Marco Polo ... rédigé en français sous sa
dictée en 1298 par Rusticien de Pise_, i. (1865) 165. ii. 490.

[1821] For further particulars, see my paper mentioned at page 493,
note 1.—F. A. F.

The _first_ route is that over the barren steppes of Central Asia by
Yarkand, Kashgar, Turkestan, and the Caspian to Russia; the _second_
by the Indus or the Persian Gulf to the Red Sea and Alexandria, or by
Persia to Syria and Asia Minor; and the _third_ by way of Canton, the
only port of the Chinese Empire which, previous to the year 1842, held
direct communication with Europe.

In 1653 China first permitted Russia to trade on her actual frontiers.
The traffic in Chinese goods was thereupon diverted from the line of
the Caspian and Black Sea further north, taking its way from Tangut
across the steppes of the high Gobi, and through Siberia by Tobolsk to
Moscow. Thus it is mentioned in 1719 that Urga on the north edge of
the Gobi desert was the principal depôt for rhubarb. From the earliest
times, Bucharian merchants appear to have been agents on this traffic,
the producers of the drug never concerning themselves about its export.

Consequent on the rectification of frontier in 1728, a line of
custom-houses was established by treaty between Russia and China,
whereby the commerce, previously unrestricted, was limited to the
government caravans which passed the frontier only at Kiachta and at
Zuruchaitu, south of Nerchinsk. The latter place always remained
unimportant, while Kiachta and the opposite Chinese town of Maimatchin
became the staple depôts of rhubarb.

The root was subjected to special control as early as 1687-1697 by
the Russian Government, who finally monopolized the trade about 1704.
Caravans fitted out by the Crown alone brought the drug to Moscow,
until 1762, when the caravan-trade was for a while thrown open. It was
not until this period that the export of rhubarb became considerable,
although the stringent regulations, established in 1736, were still
maintained. The surveillance of rhubarb was exercised at Kiachta in a
special court or office called the _Brake_,[1822] under instructions
from the Russian Minister of War, by an apothecary appointed for
six years, the object being to remove from the rhubarb brought for
inspection all inferior or spurious pieces, and to improve the selected
drug by trimming, paring and boring. It was then carefully dried, and
packed in chests, which were sown up in linen, and rendered impervious
to wet by being pitched and then covered with hide. The drug was
dispatched, but only in quantities of 1000 _puds_ (40,000 lb.), once
a year by way of Lake Baikal and Irkutsk to Moscow, whence it was
transmitted to St. Petersburg, to be there delivered to the Crown
apothecaries and in part to be sold to druggists.

We are indebted for these accounts chiefly to Calau,[1823] an
apothecary appointed to supervise the examination of rhubarb, and who
resided a long time at Kiachta. An exact account of the remarkable
policy of the Russian Government in relation to that drug was also
given by Von Schröders[1824] in 1864.

So long as China kept all her ports closed to foreign commerce except
Canton in the extreme south, a large supply of fine rhubarb found its
way to Europe by way of Russia. But the unpleasant accompaniments
of the Russian supervision, which was exercised with unsparing
severity,[1825] and the extreme tediousness of the land-transport, made
the Chinese very ready to accept an easier outlet for their goods.
Accordingly we find that the opening of a number of ports in the north
of China exerted a very depressing influence on the trade of Kiachta,
which was augmented by the rebellion that raged in the interior of
China for some years from 1852.

On these accounts Russia in 1855 removed certain restrictions on the
trade, though without abandoning the Rhubarb Office. She withdrew in
1860 the custom-house to Irkutsk, and declared Kiachta a free port,
while by the treaty with China of November 1860, she insisted on that
country abandoning all restrictions on trade.

But the overland rhubarb trade had already been destroyed: the Chinese,
tempted by the increased demand occasioned by the new trading-ports,
became less careful in the collection and curing of the root, while the
Russians insisted with the greatest strictness on the drug being of the
accustomed quality. Hence it happened that from 1860 hardly any rhubarb
was delivered at Kiachta, either for the government use or to private
traders; and in 1863 the Rhubarb Office was abolished.

[1822] From the German word _Bracke_, the name applied to persons
appointed for the examination of merchandize brought to the ports of
the Baltic.

[1823] Gauger’s _Rep. für Pharm. und Chemie_, 1842. 452-457; _Pharm.
Journ._ ii. (1843) 658.

[1824] Canstatt’s _Jahresbericht_ for 1864. i. 35-42.

[1825] Thus in 1860 the Russians compelled the Chinese to burn 6000 lb.
of rhubarb, on the pretext that it was _too small_!

Thus the so-called _Russian_ or _Muscovitic_ or _Crown Rhubarb_,
familiarly known in England as _Turkey Rhubarb_, a drug which for its
uniformly good quality long enjoyed the highest reputation, has become
a thing of the past, which can only now be found in museum collections.
It began to appear in English commerce at the commencement of the last
century. Alston,[1826] who lectured on botany and materia medica at
Edinburgh in 1720, speaks of rhubarb as brought from Turkey and the
East Indies,—“and of late, likewise from Muscovy.”

It has been shown (p. 494) that rhubarb was shipped from Syria in
the 12th century. Vasco da Gama[1827] mentions it in 1497 among the
exports of Alexandria. In fact, the drug was carried from the far
east to Persia, whence it was brought by caravans to Aleppo, Tripoli,
Alexandria, and even to Smyrna. From these Levant ports it reached
Europe, and was distributed as _Turkey Rhubarb_; while that which was
shipped direct from China, or by way of India, became known as _China_,
_Canton_, or _East India Rhubarb_. The latter was already the more
common sort in England as early as 1640.[1828]

As the rhubarb of the Levant disappeared from trade, that of Russia
took not only its place but likewise its name, until the term “_Turkey
Rhubarb_” came to be the accepted designation of the drug imported from
Russia. This strange confusion of terms was not however prevalent on
the Continent, but was chiefly limited to British trade.

The risk and expense of the enormous land-transport over almost the
whole breadth of Asia, caused rhubarb in ancient times to be one of the
very costly drugs. Thus at Alexandria in 1497, it was valued at twelve
times the price of benzoin. In France in 1542,[1829] it was worth
ten times as much as cinnamon, or more than four times the price of
saffron. At Ulm in 1596,[1830] it was more costly than opium. A German
price-list of the magistrate of Schweinfurt, of 1614, shows _Radix Rha
Barbari_ to be six times as dear as fine myrrh, and more than twice
the price of opium. An official English list[1831] giving the price
of drugs in 1657, quotes opium as 6_s._ per lb., scammony 12_s._, and
rhubarb 16_s._

=Production and Commerce=—The districts of the Chinese Empire which
produce rhubarb extend over a vast area. They are comprised in the
four northern provinces of China Proper, known as Chihli, Shansi,
Shensi,[1832] and Honan; the immense north-western province of
Kansuh, formerly partly included in Shensi, but now extending across
the desert of Gobi and to the frontiers of Tibet; the province of
Tsing-hai inhabited by Mongols, which includes the great salt lake of
Koko-nor and the districts of Tangut, Sifan, and Turfan; and lastly the
mountains of the western province of Szechuen. The plant is found on
the pasturages of the high plateaux, growing particularly well on spots
that have been enriched by encampments.

[1826] _Lectures on the Mat. Med._ i. (1770) 502.

[1827] _Roteiro da viagem de Vasco da Gama_, por A. Herculano e o Barão
de Castello de Paiva, ed. 2. Lisboa, 1861. 115.—For an abstract of the
“Roteiro,” see Flückiger, _Documente zur Geschichte der Pharm._ 1876.
13.

[1828] Parkinson, _Theatrum Botanicum_, 1640. 155.

[1829] Leber, _Appréciation de la fortune privée au moyen âge_, éd. 2.
1847. 308-9.

[1830] Reichard, _Beiträge zur Geschichte der Apotheken_, Ulm, 1825.
208.

[1831] _Book of the Values of Merchandize imported, according to which
Excize is to be paid by the First Buyer_, Lond. 1657.

[1832] According to Consul Hughes of Hankow, San-yuan in Shensi (north
of Sin-ganfu) is one of the principal marts for rhubarb.

What little we know regarding the production of rhubarb and its
preparation for the market, from Catholic missionaries,[1833] is of a
rather meagre and unsatisfactory character. The root is dug up at the
beginning of autumn when the vegetation of the plant is on the decline,
and the operation is probably continued for a few months, or in some
districts for the whole winter. It is cleaned, its cortical part sliced
off, and the root cut into pieces for drying. This is performed either
by the aid of fire-heat, or by simple exposure to sun and air, or the
pieces are first partially dried on a hot stone, and then strung on a
cord and suspended until the desiccation is complete.

According to F. von Richthofen[1834] the best rhubarb is collected
exclusively from plants growing wild in the high alps of western
Szechuen, especially in the Bayankara range, between the sources of the
Hoang-ho and the rivers Ya-lung-Kiang and Min-Kiang. This variety is
chiefly known under the name Shensi rhubarb, although the inhabitants
of the province of Szechuen pretend the superiority of the drug of
their own country. The important places for the commodity are Sining-fu
in the province of Kansu, and Kwan-hien in Szechuen. In the plain of
Tshing-tu-fu, according to Richthofen, rhubarb is cultivated in fields,
but its product is stated to be much inferior to that of the true plant
which is said not to succeed under culture.

Rhubarb is now purchased for the European market chiefly at Hankow on
the upper Yangtsze, whither it is brought from the provinces of Shensi,
Kansu, and Szechuen. From Hankow it is sent down to Shanghai, and there
shipped for Europe. The exports from Hankow are stated in official
documents[1835] to have amounted to the following numbers of peculs
(one pecul = 133⅓ lb. = 60·479 kilogrammes):

    1866      1867      1868      1869      1870      1871      1872
    2985      3425      2866      3398      3370      3859      3167

In 1877 there were exported by way of Hankow 2096 peculs from Shensi
and 3385 peculs from Szechuen.—From all the Chinese ports, 5124 peculs
of rhubarb were shipped in 1874.

Much smaller quantities (554 peculs in 1872, 1055 peculs in 1874) are
shipped from Tientsin; and there are occasional exportations from
Canton, Amoy, Foochow, and Ningpo. The imports of rhubarb into the
United Kingdom in 1870 amounted to 343,306 lb., the estimated value of
which was £62,716.[1836]

We have no information about the rhubarb which is stated by
Bellew[1837] to grow on the hills near Kayn or Ghayn in eastern Persia
(about 32½° N. lat.).

[1833] Chauveau, Vicar Apostolic of Tibet (1870), and Biet, a French
missionary, both quoted by Collin in his thesis _Des Rhubarbes_, Paris,
1871. 22. 24.

[1834] _Petermann’s Geograph. Mittheilungen_, viii. (1873) 302.

[1835] _Reports on Trade at the Treaty Ports of China for 1870_;
_Commercial Reports_ from Her Majesty’s Consuls in China, 1872. No. 3.
p. 57, and 1874 (1875) No. 5.

[1836] _Annual Statement of the Trade and Navigation of the United
Kingdom for 1870._ 79.

[1837] _From the Indus to the Tigris_, London, 1874. 321.

=Description=—China Rhubarb as imported into Europe[1838] consists
of portions of a massive root which display considerable diversity
of form, arising from the various operations of paring, slicing and
trimming, to which they have been subjected. Thus some pieces are
cylindrical or rather barrel-shaped, others conical, while a large
proportion are plano-convex, and others again are of no regular shape.
These forms are not all found in the same package, the drug being
usually sorted into _round_ and _flat rhubarb_. In dimensions we find 3
to 4 inches the commonest length, though an occasional piece 6 inches
long or more may be met with. The width may be stated at 2 to 3 inches.
The outer surface of the root is somewhat shrivelled, often exhibiting
portions of a dark bark that have not been pared away. Many pieces are
pierced with a hole, in which may be found the remains of a cord used
to suspend the root while drying. The drug is dusted over with a bright
brownish-yellow powder, on removal of which the outer side of the root
is seen to have a rusty-brown hue, or viewed with a lens to be marked
by the medullary rays, which appear as an infinity of short broken
lines of deep brown, traversing a white ground.

The character which most readily distinguishes the rhubarb of China is
that well-developed pieces, broken transversely, display these dark
lines arranged as an internal ring of _star-like spots_. Although this
character is by no means obvious in every piece of Chinese rhubarb, it
is of some utility from the fact that in European rhubarb, such spots
are generally wholly wanting, or at most occur only sparingly and in an
isolated manner.

In judging of rhubarb, great stress is laid upon the appearance of
the root when broken, and the circumstance of the fractured surface
presenting no symptoms of decay, discoloration, or sponginess.[1839]
In good rhubarb, the interior is found to be compact, and beautifully
veined with reddish-brown and white, sometimes not unmixed with
iron-grey. The root when chewed tastes gritty, by reason of the
crystals it contains of oxalate of calcium; but it is besides bitter,
astringent and nauseous. The odour is peculiar, and except by the
druggist, is mostly regarded as very disagreeable.

_Microscopic Structure_—The tissue of rhubarb is made up of a white
parenchyme, brown medullary rays and a few irregularly scattered very
large fibro-vascular bundles, which are devoid of ligneous cells.

On a transverse fracture of specimens, which are not too much peeled,
a narrow dark cambial zone may be distinguished. In that part of the
root, only the medullary rays display the usual radial arrangement, and
in the interior of the root no regular structure is met with. There
is no well-marked pith, but the central portion of the tissue shows a
mixture of white parenchyme and brown medullary rays running in every
direction. In full-grown roots, the central part is separated from the
cambial zone by the band of stellate patches[1840] already mentioned.

[1838] It is now often trimmed by wholesale druggists to simulate the
old Russian rhubarb.

[1839] The quality and appearance of rhubarb are far more regarded in
England than on the Continent. To ensure a fine powder of brilliant
hue, the drug is most carefully prepared, each root being split open,
and any dark or decayed portion removed with a chisel or file, while
the operator is not allowed to handle the drug except with leather
gloves.

[1840] Their formation has been investigated by Schmitz, Proceedings of
the “_Naturforschende Gesellschaft zu Halle_”; the author also shows
that the drug is chiefly afforded by the rhizome.—An abstract of the
paper will be found in Just’s _Botanischer Jahresbericht_, 1874. 461.

As to the contents of the white cells, they are loaded either with
starch or tufted crystals of oxalate of calcium, the amount of the
latter being especially liable to variation. Scheele, after having
discovered the oxalic acid, pointed out in 1784 that the crystals under
notice consist of that acid in combination with lime; he was the first
to point out the true composition of those crystals which are of so
wide a distribution throughout the vegetable kingdom. The medullary
rays contain the substances peculiar to rhubarb, but none of them occur
in a crystalline state.

=Chemical Composition=—The active constituent of the root has long
been supposed to reside in the yellowish-red contents of the medullary
rays. Schrader as early as 1807 prepared a _Rhubarb-Bitter_, to which
he attributed the medicinal powers of the drug. Since then several
substances of the same kind have been separated by various methods,
and described under different names: such are the _Rhabarberstoff_ of
Trommsdorff, the _Rheumin_ of Hornemann, the _Rhabarberin_ of Buchner
and Herberger, the _Rhubarb-Yellow_ or _Rheïn_, and the _Rhabarbaric
Acid_ of Brandes.

Schlossberger and Döpping in 1844 first recognized among the
above-named substances a definite chemical body named _Chrysophan_ or
_Chrysophanic Acid_,

          {CH₃ }
    C₁₄H₅ {   }O₂,
          {(OH)₂}

which had been found in 1843 by Rochleder and Heldt in the yellow
lichen, _Parmelia parietina_. It partly forms the yellow contents of
the medullary rays of rhubarb, and when isolated crystallizes in golden
yellow needles or in plates. It dissolves in ether, alcohol, or benzol;
though scarcely soluble in water, it is nevertheless extracted from
the root to some extent by that solvent, probably by reason of some
accompanying substance. Alkalis dissolve it, forming fine dark red
solutions. Chrysophan, C₁₅H₁₀O₄, is a derivative of anthracene, C₁₄H₁₀,
and closely allied to alizarin, C₁₄H₈O₄.

By precipitating alcoholic solutions of extract of rhubarb with ether,
Schlossberger and Döpping obtained, together with chrysophan, resinous
bodies which they named _Aporetin_, _Phæoretin_ and _Erythroretin_.

De la Rue and Müller (1857) extracted from rhubarb, in addition to
chrysophan, an allied substance, _Emodin_, which crystallizes in
orange-coloured prisms, sometimes as much as two inches long. Its
constitution was subsequently found to agree with the formula

          {CH₃  }
    C₁₄H₄ {     }O₂.
          {(OH)₃}

Kubly (1867) has obtained from rhubarb the following constituents:—

1. _Rheo-tannic Acid_, C₂₆H₂₆O₁₄, a yellowish powder abundantly present
in rhubarb, soluble in water or alcohol, not in ether. Its solutions
produce blackish-green precipitates with persalts of iron, and greyish
ones slowly turning blue, with protosalts of the same.

2. _Rheumic Acid_ (_Rheumsäure_), C₂₀H₁₆O₉, obtained as a reddish-brown
powder, by boiling rheo-tannic acid with a dilute mineral acid, a
fermentable sugar being developed at the same time. Rheumic acid
exhibits nearly the same reactions as rheo-tannic acid, but is very
sparingly soluble in cold water. It partly pre-exists in rhubarb.

3. Neutral _colourless_ substance, sparingly soluble in hot water, and
separating from the latter in prismatic _crystals_ of the formula
C₁₀H₁₂O₄; no name has yet been given to it. A “white crystalline resin”
(and a dark brown crystalline resin) has been isolated in 1878 by
Dragendorff.

4. _Phæoretin_, C₁₆H₁₆O₇, agreeing with the substance thus named by
Schlossberger and Döpping. It is a brown powder, soluble in alcohol or
in acetic acid, but not in ether, chloroform or water.

5. _Chrysophan_, described above.

According to Dragendorff (1878) _mucilaginous matters_ occur in the
different varieties of rhubarb to the amount of from 11 to 17 per
cent. He states them to consist of mucilage (properly so called),
arabic acid, metarabic acid and pararabin, and moreover enumerates also
pectose among the constituents of the drug.

Small quantities of albuminoid substances, malic acid, fat and sugar
have also been met with in rhubarb. As to its mineral constituents,
their amount is exceedingly variable. Two samples of good China Rhubarb
dried at 100° C. and incinerated, yielded us respectively 12·9 and
13·87 per cent. of ash. Another sample, which we had particularly
selected on account of its pale tint, afforded no less than 43·27 per
cent. of ash. The ash consists of carbonates of calcium and potassium.
English rhubarb from Banbury (portions of a large specimen) left after
incineration 10·90 per cent. of ash.

From a practical point of view the chemical history of rhubarb is far
from satisfactory, for we are still ignorant to what principle the drug
owes its therapeutic value, or what are the pharmaceutical preparations
in which the active matter may be most appropriately exhibited.
Chrysophan is said to act as a purgative, but less powerfully than
rhubarb itself.

=Uses=—Rhubarb is one of the commonest and most valuable purgatives; it
is also taken as a stomachic and tonic.

=Substitutes=—These are found in the roots of the various species of
_Rheum_ cultivated in Europe. In most countries, the cultivation of
rhubarb for medicinal use has at some time been attempted. Yet in but
few instances has it been persistently carried on; and though the drug
produced has often been of good appearance, it has failed to gain
the confidence of medical men, and to acquire much importance in the
drug-market. The European rhubarb most interesting from our point of
view is

_English Rhubarb_—So early as 1535, Andrew Boorde, an English
Carthusian monk and practitioner of medicine, obtained seeds of
rhubarb, which he sent as “_a grett tresure_” to Sir Thomas Cromwell,
Secretary of State to Henry VIII.; but as he says they “_come
owtt of barbary_” we must be allowed to hold their genuineness as
doubtful.[1841]

In the following century, namely about the year 1608, Prosper Alpinus
of Padua cultivated as the True Rhubarb a plant which is now known as
_Rheum Rhaponticum_ L., a native of Southern Siberia and the regions
of the Volga.[1842] From this stock, Sir Matthew Lister, physician
to Charles I., procured seeds when in Italy, and gave them to
Parkinson,[1843] who raised plants from them.

[1841] Boorde’s _Introduction and Dyetary_, reprinted by the Early
English Text Society, 1870. 56.

[1842] Prosper Alpinus, _De Rhapontico_, Lugd. Bat. 1718.

[1843] _Theatrum Botanicum_, 1640. 157.

Collinson obtained rhubarb plants from seeds procured in Tartary, and
sent to him in 1742 by Professor Siegesbeck of St. Petersburg.[1844]

About 1777 Hayward, an apothecary of Banbury in Oxfordshire, commenced
the cultivation of rhubarb with plants of _Rh. Rhaponticum_, raised
from seeds sent from Russia in 1762. The drug he produced was so good
that the Society of Arts awarded him in 1789 a silver medal, and in
1794 a gold medal.[1845] The Society also awarded medals about the same
time (1789-1793) to growers of rhubarb in Somersetshire, Yorkshire, and
Middlesex, some of whom, it appears, cultivated _Rh. palmatum_. On the
death of Hayward in 1811, his rhubarb plants came into the possession
of Mr. P. Usher, by whose descendants, Mr. R. Usher and sons, they are
still cultivated at Bodicott, a village near Banbury.

The authors of this book had the pleasure of inspecting the rhubarb
fields of Messrs. Usher on Sept. 4, 1872, and of seeing the whole
process of preparing the root for the market.[1846] The land under
cultivation is about 17 acres, the soil being a rich friable loam.
The roots are taken from the ground during the autumn up to the month
of November. It is considered advantageous that they should be 6 or
7 years old, but they are seldom allowed to attain more than 3 or 4
years. The clumps of root as removed from the field to the yard, where
the trimming takes place, are of huge size, weighing with the earth
attached to them as much as 60 or 70 lb. They are partially cleaned,
the smaller roots are cut off, and the large central portion is rapidly
trimmed into a short, cylindrical mass the size of a child’s head.
This latter subsequently undergoes a still further paring, and is
finally sliced longitudinally; the other and less valuable roots are
also pared, trimmed, and assorted according to size. The fresh roots
are fleshy, easily cut, and of a beautiful deep yellow. All are dried
in buildings constructed for the purpose, and heated by flues. The
drying occupies several weeks. The root after drying has a shrivelled,
unsightly appearance, which may be remedied by paring and filing. The
finished drug has to be stored in a warm dry place.

When well prepared, Banbury rhubarb is of excellent appearance. The
finest pieces, which are semi-cylindrical, are quite equal in size to
the drug of China. The colour is as good, and the fractured surface
exhibits pink markings not less distinct and brilliant. Even the
smaller roots, which are dried as sticks, have internally a good
colour, and afford a fine powder. But the odour is somewhat different
from that of Chinese rhubarb; the taste is less bitter but more
mucilaginous and astringent, and the root is of a more spongy, soft,
and brittle texture. The structure is the same as that of the Chinese
rhubarb, except that, as already stated, the star-like spots, if
present, are isolated, and not arranged in a regular zone.

The drug commands but a low price, and is chiefly sold, it is said,
for exportation in the state of powder. It is not easily purchased in
London.

[1844] Dillwyn, _Hortus Collinsonianus_, 1843. 45.

[1845] _Trans. of Soc. of Arts_, viii. (1790) 75; xii. (1794) 225.

[1846] No use is made of the leaves.—Some further particulars are given
by Holmes, _Pharm. Journal_, vii. (1877) 1017.

_French and German Rhubarb_—The cultivation of rhubarb was commenced
in France in the latter half of the last century, and has been pursued
with some enthusiasm in various localities. The species grown were
_Rheum palmatum_ L., _Rh. undulatum_ L., _Rh. compactum_ L., and _Rh.
Rhaponticum_ L. The first was thought by Guibourt[1847] to afford a
root more nearly approaching than any other the rhubarb of China; but
it is that which is cultivated the least readily, the central root
being liable to premature decay. Both this plant and _Rh. undulatum_
were formerly cultivated by order of the Russian Government on a large
scale at Kolywan and Krasnojarsk in Southern Siberia, but the culture
has, we believe, been long abandoned.[1848]

As to France, it appears from inquiries we have lately made (1873),
that except in the neighbourhood of Avignon and in a few other
scattered localities, the cultivation has now ceased.

_Rheum Rhaponticum_ is the source of the rhubarb which is produced
at Austerlitz and Auspitz in Moravia, and at Ilmitz, Kremnitz and
Frauenkirchen in Hungary. Some rhubarb is also produced in Silesia from
_Rh. Emodi_ Wall. (_Rh. australe_ Don.).




MYRISTICEÆ.


MYRISTICA.

_Nuclei Myristicæ_, _Semen Myristicæ_, _Nux moschata_; _Nutmeg_; F.
_Muscade_, _Noix de Muscade_; G. _Muskatnuss_.

=Botanical Origin=—_Myristica fragrans_ Houttuyn (_M. moschata_ Thunb.,
_M. officinalis_ Linn. f.), a handsome, bushy, evergreen tree,[1849]
with dark shining leaves, growing in its native islands to a height of
40 to 50 feet. It is found wild in the very small volcanic group of
Banda, from Damma to Amboina, in Ceram, Bouro, Jilolo (Halmahera), the
western peninsula of New Guinea, and in many of the adjacent islands,
but it is not indigenous to any of the islands westward of these, or to
the Philippines (Crawfurd).

The nutmeg tree has been introduced into Bencoolen on the west coast of
Sumatra, Malacca, Bengal, the islands of Singapore and Penang, as well
as Brazil and the West Indies; but it is only in a very few localities
that the cultivation has been attended with success.

In its native countries the tree comes into bearing in its ninth
year, and is said to continue fruitful until 60 or even 80 years old,
yielding annually as many as 2000 fruits. It is diœcious, and one male
tree furnishes pollen sufficient for twenty female.

=History=—It has been generally believed that neither the nutmeg nor
mace was known to the ancients. C. F. Ph. von Martius[1850] however
maintains that mace was alluded to in the comedies of Plautus,[1851]
written about two centuries before the Christian era.

[1847] _Histoire des Drogues_, ii. (1849) 398.

[1848] Twelve chests of this rhubarb, said to be of the crop of 1793,
which had been lying in the Russian Government warehouses, were offered
for sale in London, Dec. 1, 1853. Samples of the drug now 80 years old
are in our possession, and still sound and good.

[1849] Most beautifully figured by Blume, “Rumphia” i. (1835) tab. 55;
_Myristica fatua_, ii. 59.

[1850] _Flora Brasiliensis_, fasc. 11-12. 133; also in Buchner’s
_Repertorium für Pharmacie_, ix. (1860) 529-538.

[1851] _Pseudolus_, act. iii. scena 2.

The words _Macer_, _Macar_, _Machir_ or _Macir_, occurring in the
writings of Scribonius Largus, Dioscorides, Galen, and Pliny are
thought by Martius to refer in each instance to mace. But that the
substance designated by these names was not mace, but the bark of
a tree growing in Malabar, was pointed out by Acosta nearly three
centuries ago, and by many subsequent writers, and, as we think, with
perfect correctness.[1852]

Nutmegs and mace were imported from India at an early date by the
Arabians, and thus passed into western countries. Aëtius, who was
resident at the court of Constantinople about the year 540, appears to
have been acquainted with the nutmeg, if that at least is intended by
the term _Nuces Indicæ_, prescribed together with cloves, spikenard,
costus, calamus aromaticus and snadal-wood, as an ingredient of the
_Suffumigium moschatum_.[1853]

Masudi,[1854] who appears to have visited India in A.D. 916-920,
pointed out that the nutmeg, like cloves, areca nut and snadal-wood,
was a product of the eastern islands of the Indian Archipelago. The
Arabian geographer Edrisi, who wrote in the middle of the 12th century,
mentions both nutmegs and mace as articles of import into Aden;[1855]
and again “_Nois mouscades_” are among the spices on which duty was
levied at Acre in Palestine, _circa_ A.D. 1180.[1856] About a century
later, another Arabian author, Kazwini,[1857] expressly named the
Moluccas as the native country of the spices under notice.

The Sanskrit name of the nutmeg tree most commonly in use, also with
Susruta, is Jātī (Dr. Rice).

One of the earliest references to the use of nutmegs in Europe occurs
in a poem written about 1195, by Petrus D’Ebulo,[1858] describing the
entry into Rome of the Emperor Henry VI., prior to his coronation in
April 1191. On this occasion the streets were fumigated with aromatics,
which are enumerated in the following line:—

“Balsama, thus, aloë, _myristica_, cynnama, nardus.”

By the end of the 12th century, both nutmegs and mace were found in
Northern Europe,—even in Denmark, as may be inferred from the allusion
to them in the writings of Harpestreng.[1859] In England, mace, though
well known, was a very costly spice, its value between A.D. 1284
and 1377 being about 4_s._ 7_d._ per lb., while the average price
of a sheep during the same period was but 1_s._ 5_d._, and of a cow
9_s._ 5_d._[1860] It was also dear in France, for in the _Compte de
l’exécution_ of the will of Jeanne d’Evreux, queen of France, in 1372,
six ounces of mace are appraised per ounce at 3 sols 8 deniers, equal
to about 8_s._ 3_d._ of our present money.[1861]

[1852] Mérat et De Lens, _Dict. de Mat. Méd._ iv. (1832) 173.—The tree
is, we think, _Ailantus malabarica_ DC., order of the Simarubeæ.

[1853] Aëtius, tetrabiblos iv. serm. 4. c. 122.—It must however be
admitted that _Nux Indica_ in mediæval authors usually signifies the
Coco-nut, but also sometimes _Nux vomica_ or even _Areca nut_. For
particulars see Flückiger, _Documente zur Geschichte der Pharm._ 1876.
18.

[1854] _Les prairies d’or_, i. (1861) 341.

[1855] _Géographie_, i. (1836) 51.

[1856] In the work quoted at p. 282, note 3.

[1857] _Kosmographie_, übersetzt von Ethé, i. (1869) 227.

[1858] _Carmen de motibus siculis_, Basil., 1746. 23.—A new edition of
this work, by Prof. Winkelmann, was published in 1874.

[1859] _Danske Laegebog_, quoted by Meyer, _Geschichte der Botanik_,
iii. (1856) 537.

[1860] Rogers, _Hist. of Agriculture and Prices in England_, i. (1866)
361-362. 628.—It is remarkable that _nutmegs_ are not mentioned, though
_mace_ is named repeatedly.

[1861] Leber, _Appréciation de la fortune privée au moyen âge_, éd. 2,
1847. 95.

The use of these spices was diffused throughout Europe long before the
Portuguese in 1512 had discovered the mother plant in the isles of
Banda. The Portuguese held the trade of the Spice Islands for about
a century, when it was wrested from them by the Dutch, who pursued
the same policy of exclusiveness that they had followed in the case
of cloves and cinnamon. In order to secure their monopoly, they
endeavoured to limit the trees to Banda and Amboyna, and to exterminate
them elsewhere, which in fact they did at Ceram and the small
neighbouring islands of Kelang and Nila. So completely was the spice
trade in their hands, that the crops of sixteen years were said to be
at one time in their warehouses, those of recent years being never
thrown on the market. Thus the crop of 1744 was being sold in 1760,
in which year an immense quantity of nutmegs and cloves was burned at
Amsterdam lest the price should fall too low.[1862]

During the occupation of the Spice Islands by the English from 1796
to 1802, the culture of the nutmeg was introduced into Bencoolen and
Penang,[1863] and many years afterwards into Singapore. Extensive
plantations of nutmeg-trees were formed in the two islands last named,
and by a laborious and costly system of cultivation were for many
years highly productive.[1864] In 1860 the trees were visited by a
destructive blight, which the cultivators were powerless to arrest,
and which ultimately led to the ruin of the plantations, so that in
1867 there was no such thing as nutmeg cultivation either in Penang or
Singapore.[1865]

Though so long valued in Europe and Asia, neither nutmegs nor mace seem
to have been employed in former times as a condiment in the islands
where they are indigenous.[1866]

=Collection and Preparation=—Almost the whole surface of the Banda
Isles, observes Mr. Wallace,[1867] is planted with nutmeg-trees, which
thrive under the shade of the lofty _Canarium commune_. The light
volcanic soil, the shade, and the excessive moisture of these islands,
where it rains more or less every month in the year, seem exactly
to suit the nutmeg tree, which requires no manure and scarcely any
attention.

In Bencoolen[1868] the trees bear all the year round, but the chief
harvest takes place in the later months of the year, and a smaller one
in April, May and June. The fruit as it splits is gathered by means of
a hook attached to a long stick, the pericarp removed, and the mace
carefully stripped off. The nuts are then taken to the drying house
(a brick building), placed on frames, and exposed to the gentle heat
of a smouldering fire, with arrangements for a proper circulation of
air. This drying operation lasts for two months, during which time
the nutmegs are turned every second or third day. At the end of this
period, the kernels are found to rattle in the shell, an indication
that the drying is complete. The shells are then broken with a wooden
mallet, the nutmegs picked out and sorted, and finally rubbed over with
dry sifted lime. In Banda the smaller and less sightly nutmegs are
reserved for the preparation of the expressed oil.

[1862] Valmont de Bomare, _Dict. d’Histoire Nat._ iv. (1775) 297.—This
author writes as an eye-witness of the destruction he has recorded:—“Le
10 Juin 1760, j’en ai vu à Amsterdam, près de l’Amirauté, un feu dont
l’aliment étoit estimé huit millions argent de France: on devoit en
brûler autant le lendemain. Les pieds des spectateurs baignoient dans
l’huile essentielle de ces substances....”

[1863] How tempting the cultivation must have appeared, may be judged
from the price of mace, which we find quoted on the 3rd January 1806,
in the _London Price Current_ (which gives only _import prices_), as
85_s._ to 90_s._ per lb.;—to these rates must be added the duty of
7_s._ 1_d._ per lb.

[1864] Seemann, _Hooker’s Journ. of Bot._ iv. (1852) 83.

[1865] Collingwood in _Journ. of Linnean Society_, Bot., x. (1869) 45.

[1866] Crawfurd, _Dictionary of the Indian Islands_, 1856. 304.—Much
additional information will be found in this work.

[1867] _The Malay Archipelago_, i. (1869) 452.—See also Bickmore,
_Travels in the East Indian Archipelago_, 1868. 225.

[1868] Lumsdaine, _Pharm. Journ._ xi. (1852) 516. For further
information on the management of nutmeg plantations in Sumatra, consult
the original paper.

The old commercial policy of the Dutch originated the singular practice
of breaking the shell, and immersing the kernel of the artificially
dried seed in milk of lime,—sometimes for a period of three months.
This was done with a view to render impossible the germination of
any nutmegs sent into the market. The folly of such a procedure was
demonstrated by Teijsmann, who proved that mere exposure to the sun for
a week is sufficient to destroy the vitality of the seed. By immersion
in milk of lime many nutmegs are spoiled and the necessity is incurred
of a second drying. Lumsdaine has also shown that even the _dry_ liming
process is, to say the least, entirely needless. Nutmegs are well
preserved in their natural shell, in which state the Chinese have the
good sense to prefer them.

The process of liming nutmegs is however still largely followed; and
the prejudice in favour of the spice thus prepared is so strong in
certain countries, that nutmegs not limed abroad have sometimes to be
limed in London to fit them for exportation. Penang nutmegs are always
imported in the natural state,—that is, _un-limed_.

=Description=—The fruit of _Myristica fragrans_ is a pendulous, globose
drupe, about 2 inches in diameter, and not unlike a small round pear.
It is marked by a furrow which passes round it, and by which at
maturity its thick fleshy pericarp splits into two pieces, exhibiting
in its interior a single seed, enveloped in a fleshy foliaceous mantle
or arillus, of fine crimson hue, which is _mace_. The dark brown,
shining, ovate seed is marked with impressions corresponding to the
lobes of the arillus; and on one side, which is of paler hue and
slightly flattened, a line indicating the raphe may be observed.

The bony testa does not find its way into European commerce, the
so-called _nutmeg_ being merely the kernel or nucleus of the
seed. Nutmegs exhibit nearly the form of their outer shell with a
corresponding diminution in size. The London dealers esteem them in
proportion to their size, the largest, which are about one inch long by
⁸/₁₀ of an inch broad, and four of which will weigh an ounce, fetching
the highest price. If not dressed with lime, they are of a greyish
brown, smooth yet coarsely furrowed and veined longitudinally, marked
on the flatter side with a shallow groove. A transverse section shows
that the inner seed-coat (_endopleura_) penetrates into the albumen
in long narrow brown strips, reaching the centre of the seed, thereby
imparting the peculiar marbled appearance familiar in a cut nutmeg.

At the base of the albumen and close to the hilum, is the embryo,
formed of a short radicle with cup-shaped cotyledons, whose slit and
curled edges penetrate into the albumen. The tissue of the seed can be
cut with equal facility in any direction. It is extremely oily, and has
a delicious aromatic fragrance, with a spicy rather acrid taste.

=Microscopic Structure=—The testa consists mainly of long, thin,
radially arranged, rigid cells, which are closely interlaced and do not
exhibit any distinct cavities. The endopleura which forms the adhering
coat of the kernel and penetrates into it, consists of soft-walled,
red-brown tissue, with small scattered bundles of vessels. In the
outer layers the endopleura exhibits small collapsed cells; but the
tissue which fills the folds that dip into the interior consists of
much larger cells. The tissue of the albumen is formed of soft-walled
parenchyme, which is densely filled with conspicuous starch-grains, and
with fat, partly crystallized. Among the prismatic crystals of fat,
large thick rhombic or six-sided tables may often be observed. With
these are associated grains of albuminoid matter, partly crystallized.

=Chemical Composition=—After starch and albuminoid matter, the
principal constituent of nutmeg is the _fat_, which makes up about a
fourth of its weight, and is known in commerce by the incorrect name of
_Oil of Mace_ (see p. 507).

The volatile oil, to which the smell and taste of nutmegs are chiefly
due, amounts to between 3 and 8 per cent.,[1869] and consists,
according to Cloëz (1864), almost entirely of a hydrocarbon, C₁₀H₁₆,
boiling at 165° C., which Gladstone (1872), who assigns it the same
composition, calls _Myristicene_. The latter chemist found in the crude
oil an oxygenated oil, _Myristicol_, of very difficult purification
and possibly subject to change during the process of rectifying. It
has a high boiling point (about 220° C.?) and the characteristic odour
of nutmeg; unlike carvol with which it is isomeric, it does not form a
crystalline compound with hydrosulphuric acid.

Oil of nutmegs, distilled in London by Messrs. Herrings and Co.,
examined in column 200 mm. long, we found to deviate the ray of
polarized light, 15°·3 to the right; that of the Long Nutmeg
(_Myristica fatua_ Houtt.), furnished to us by the same firm, deviated
28°·7 to the right.

From the facts recorded by Gmelin,[1870] it would appear that oil of
nutmeg sometimes deposits a stearoptene called _Myristicin_. We are
not acquainted with such a deposit; yet we have been kindly furnished
by Messrs. Herrings with a crystalline substance which they obtained
during the latter part of the process of distilling both common
and long nutmegs. It is a greyish greasy mass, which by repeated
crystallizations from spirit of wine, we obtained in the form of
brilliant, colourless scales, fusible at 54° C., and still possessing
the odour of nutmeg. The crystals are readily soluble in benzol,
bisulphide of carbon or chloroform, sparingly in petroleum ether; their
solution in spirit of wine has a decidedly acid reaction, and is devoid
of rotatory power. By boiling them with alcohol, sp. gr. 0·843, and
anhydrous carbonate of sodium, we obtained a solution which, after
removal of the alcohol, left a residuum perfectly soluble in boiling
water, forming a jelly on cooling. By adding hydrochloric acid to the
warm aqueous solution, the original crystallizable substance again made
its appearance, yet almost devoid of odour. It is in fact nothing else
than _Myristic Acid_ (see page 508).[1871]

[1869] Messrs. Herrings & Co. of London have informed us, that 2874 lb.
of nutmegs distilled in their laboratory afforded 67 lb. of essential
oil, _i.e._ 2·33 per cent. But Messrs. Schimmel & Co., Leipzig, state
(1878) that they obtain as much as from 6 to 8 per cent.

[1870] _Chemistry_, xiv. (1860) 389.

[1871] _Yearbook of Pharmacy_, 1874, 490.

=Production and Commerce=—The nutmegs and mace now brought into the
market are to a large extent the produce of the Banda Islands,[1872]
of which however only three, namely Lontar or the Great Banda, Pulo
Ai, and Pulo Nera, have what are termed _Nutmeg Parks_. According to
official statements of the Dutch, the first-named island possessed in
1864 about 266,000 fruit-bearing trees; Ternate on the western coast of
Jilolo, 46,000; Menado in the island of Celebes, 35,000; and Amboyna,
only 31,000. The nutmegs of the Banda Islands are shipped to Batavia.
The quantity exported from Java in 1871 (all, we believe, from Batavia,
and therefore the produce of the Banda Islands) is stated as 8107
peculs (1,080,933 lb.), of which 2300 peculs (306,666 lb.) were shipped
to the United States, and a rather large quantity to Singapore.[1873]
The last named port also shipped in the same year a very large quantity
(310,576 lb.) of nutmegs to North America,[1874] and in 1877 the total
export of nutmegs and mace from Singapore was 5323 peculs (709,733 lb.).

[1872] Some idea of the extremely small area of these famous islands
may be gathered from the fact that the Great Banda, the largest of
them, is but about 7 miles long by 2 miles broad; while the entire
group occupies no more than 17·6 geographical square miles.

[1873] _Consular Reports_, Aug. 1873. 952-3. In 1875, 8990 peculs were
exported from Java.

[1874] _Blue Books for the Colony of the Straits Settlements for 1871_,
Singapore, 1872.

Nutmegs were exported from Padang in Sumatra in the year 1871, to the
extent of 2766 peculs (368,800 lb.), chiefly to America and Singapore.
The quantity annually imported into the United Kingdom ranges from
500,000 to 800,000 lb.

=Uses=—Nutmeg is a grateful aromatic stimulant, chiefly employed for
flavouring other medicines. It is also in constant use as a condiment,
though less appreciated than formerly.


Oleum Myristicæ expressum.

_Oleum Macidis_, _Balsamum vel Oleum Nucistæ_; _Expressed Oil of
Nutmegs_, _Nutmeg Butter_, _Oil of Mace_; F. _Beurre de Muscade_; G.
_Muskatbutter_, _Muskatnussöl_.

This article reaches England chiefly from Singapore, in oblong,
rectangular blocks, about 10 inches long by 2½ inches square, enveloped
in a wrapper of palm leaves. It is a solid unctuous substance of an
orange-brown colour, varying in intensity of shade, and presenting a
mottled aspect. It has a very agreeable odour and a fatty aromatic
taste.

In operating on 2 lb. of nutmegs, first powdered and heated in a
water-bath and pressed while still hot, we obtained 9 ounces of solid
oil, equivalent to 28 per cent. This oil, which in colour, odour and
consistence does not differ from that which is imported, melts at
about 45° C.; and dissolves perfectly in two parts of warm ether or in
four of warm alcohol sp. gr. ·800.

Nutmeg butter contains the volatile oil already described, to the
extent of about six per cent., besides several fatty bodies. One of the
latter, termed _Myristin_ C₃H₅(O·C₁₄H₂₇O)₃, may be obtained by means
of benzol, or by dissolving in ether that part of the butter of nutmeg
which is insoluble in cold spirit of wine. The crystals of myristin
melt at 31° C. By saponification they furnish glycerin, and _Myristic
Acid_, C₁₄H₂₈O₂, the latter fusing at 53°·8 C. Playfair in 1841 was the
first to isolate (in Liebig’s laboratory at Giessen) myristic acid.
Myristin also occurs in spermaceti, coco-nuts, as well as, according to
Mulder, in small quantity, in the fixed oils of linseed and poppy seed.
Nutmegs according to Comar (1859) yield 10 to 12 per cent. of myristin.

That part of nutmeg butter, which is more readily soluble in spirit of
wine or benzol, contains another fat, which however has not yet been
investigated. It is accompanied by a reddish colouring matter.


MACIS.

_Mace_; F. _Macis_; G. _Macis_, _Muskatblüthe_.

=Botanical Origin=—_Myristica fragrans_ Houttuyn (see p. 502). The
seed which, deprived of its hard outer shell or testa, is known as
the _nutmeg_, is enclosed when fresh in a fleshy net-like envelope,
somewhat resembling the husk of a filbert. This organ, which is united,
though not very closely, at the base of the stony shell both with the
hilum and the contiguous portion of the raphe, of which parts it is
an expansion, is termed _arillus_,[1875] and when separated and dried
constitutes the mace of the shops. In the fresh state it is fleshy, and
of a beautiful crimson; it envelopes the seed completely only at the
base, afterwards dividing itself into broad flat lobes; which branch
into narrower strips overlapping one another towards the summit.

[1875] On the nature and origin of this organ, see Baillon, _Histoire
des Plantes_, ii. (1870) 499; also _Dictionnaire de Botanique_.

=History=—Included in that of the nutmeg (see preceding article).

=Description=—The mace, separated from the seed by hand, is dried
in the sun, thereby losing its brilliant red hue and acquiring an
orange-brown colour. It has a dull fatty lustre, exudes oil when
pressed with the nail, and is horny, brittle, and translucent. Steeped
in water it swells rather considerably. The entire arillus, compressed
and crumpled by packing, is about 1¾ inches long with a general
thickness of about ¹/₂₀ of an inch or even at ⅒ the base. Mace has
an agreeable aromatic smell nearly resembling that of nutmeg, and a
pungent, spicy, rather acrid taste.

=Microscopic Structure=—The uniform, small-celled, angular parenchyme
is interrupted by numerous brown oil-cells of larger size. The inner
part of the tissue contains also thin brown vascular bundles. The
cells of the epidermis on either side are colourless, thick-walled,
longitudinally extended, and covered with a peculiar cuticle of
broad, flat, riband-like cells, which cannot however be removed as
a continuous film. The parenchyme is loaded with small granules, to
which a red colour is imparted by Millon’s test (solution of mercurous
nitrate) and an orange hue by iodine. The granules consequently consist
of albuminous matter, and starch is altogether wanting.

=Chemical Composition=—The nature of the chemical constituents of
mace may be inferred from the following experiments performed by one
of us:—17 grammes of finely powdered mace were entirely exhausted by
boiling ether, and the latter allowed to evaporate. It left behind
5·57 grm., which after drying at 100° C. were diminished to 4·17. The
difference, 1·40 grammes, answers to the amount of _essential oil_, of
which consequently 8·2 per cent. had been present.

The residue, amounting to 24·5 per cent., was a thickish aromatic
_balsam_, in which we have not been able to ascertain the presence of
_fat_; it consisted of resin and semi-resinified essential oil. Alcohol
further removed 1·4 per cent. of an uncrystallizable sugar, which
reduced cupric oxide.

The drug having been thus treated with ether and with alcohol, yielded
almost nothing to cold water, but by means of boiling water 1·8 per
cent. of a mucilage was obtained, which turned blue by addition of
iodine, or reddish violet if previously dried. This substance is not
soluble in an ammoniacal solution of cupric oxide; it appears rather
to be an intermediate body between mucilage and starch.[1876] The
composition of mace is therefore very different from that of nutmeg.

As to the _volatile oil_, of which several observers have obtained from
7 to 9 per cent.,[1877] it is a fragrant colourless liquid which we
found, when examined in a column 200 mm. long, deviated the ray 18°·8
to the right. Its greater portion consists according to Schacht (1862)
of _Macene_, C₁₀H₁₆, boiling at 160° C., and distinguished from oil of
turpentine by not forming a crystalline hydrate when mixed with alcohol
and nitric acid. Koller (1865) states that macene is identical with the
hydrocarbon of oil of nutmeg (myristicene), yet the latter is said by
Cloëz to yield no solid compound when treated with hydrochloric gas.
Macene on the other hand furnishes crystals of C₁₀H₁₆·HCl. Crude oil of
mace contains, like that of nutmeg, an oxygenated oil, the properties
of which have not yet been investigated.

=Commerce=—Mace, mostly the produce as it would appear of the Banda
Islands, was shipped from Java in 1871 to the extent of 2101 peculs
(282,133 lb.); and from Padang in Sumatra (excluding shipments to Java)
to the amount of 457 peculs (60,933 lb.).[1878] The spice is exported
principally to Holland, Singapore, and the United States; Great Britain
receives about 60,000 to 80,000 lb. annually.

=Uses=—Mace is but rarely employed in medicine. It is chiefly consumed
as a condiment.

[1876] See my paper: _Ueber Stärke und Cellulose in Archiv der Pharm._
196 (1871) 31.—F. A. F.

[1877] In an actual experiment (1868) in the laboratory of Messrs.
Herrings & Co., London, 23 lb. of mace yielded 23 oz. of volatile
oil, which is equivalent to 6¼ per cent.; but Messrs. Schimmel & Co.,
Leipzig, obligingly inform us (1878) that they observed a percentage of
from 11 to 17.

[1878] _Consular Reports_, August 1873. 952-3.




LAURACEÆ.


CAMPHORA.

_Camphor_,[1879] _Common Camphor_, _Laurel Camphor_; F. _Camphre_; G.
_Campher_.

=Botanical Origin=—_Cinnamomum Camphora_ Fr. Nees et Ebermaier (_Laurus
Camphora_ L., _Camphora officinarum_ C. Bauh.), the Camphor tree or
Camphor Laurel is widely diffused, being found throughout Central China
and in the Japanese Islands. In China it abounds principally in the
eastern and central provinces, as in Chekiang, Fokien and Kiangsi; but
it is wanting, according to Garnier (1868), in Yünnan and Szechuen.
It is plentiful, on the other hand, in the island of Formosa, where
it covers the whole line of mountains from north to south, up to an
elevation of 2000 feet above the level of the sea. It flourishes in
tropical and subtropical countries, and forms a large and handsome
tree in sheltered spots in Italy as far north as the Lago Maggiore.
The leaves are small, shining, and glaucous beneath, and have long
petioles; the stem affords excellent timber, much prized on account of
its odour for making clothes’ chests and drawers of cabinets.

_Dryobalanops aromatica_, the camphor tree of Borneo and Sumatra,
yields a peculiar camphor, which we shall describe further on.

=History=—The two kinds of Camphor afforded by the two trees just
named have always been regarded by the Chinese as perfectly distinct
substances, and in considering the history of camphor this fact must be
borne in mind.

On perusing the accounts of Laurel Camphor given by Chinese
writers,[1880] the remarkable fact becomes apparent, that although the
tree was evidently well known in the 6th century, and probably even
earlier, and is specially noticed on account of its valuable timber, no
mention is made in connexion with it of any such substance as _camphor_.

Le-she-chin, the author of the celebrated herbal _Pun-tsao-kang-muh_,
written in the middle of the 16th century, was well acquainted with the
two sorts of camphor,—the one produced by the camphor laurel of his own
country, the other imported from the Malay islands; and he narrates how
the former was prepared by boiling the wood, and refined by repeated
dry sublimations.

Marco Polo, towards the end of the 13th century, saw the forests of
Fokien in South-eastern China, in which, says he, are many of the trees
which give camphor.[1881] It would thus appear that Laurel Camphor was
known as early as the time of Marco Polo, yet it is certain that the
more ancient notices which we shall now quote have reference to the
much valued Malay Camphor, which remains up to the present day one of
the most precious substances of its class.

[1879] The word _Camphor_, generally written by old Latin authors
_Caphura_, and by English _Camphire_, is derived from the Arabic
_Káfúr_, which in turn is supposed to come from the Sanskrit _Karpūra_,
signifying _white_.

[1880] Passages from several have been translated and kindly placed
at our disposal by Mr. A. Wylie. Dr. Bretschneider of Pekin and Mr.
Pauthier of Paris (see p. 494, note 7,) have also been good enough to
aid us in the same manner.

[1881] Yule, _Book of Ser Marco Polo_, ii. (1871) 185.

There is no evidence that camphor reached Europe during the classical
period of Greece and Rome. The first mention of it known to us
occurs in one of the most ancient monuments of the Arabic language,
the poems of Imru-l-Kais,[1882] a prince of the Kindah dynasty, who
lived in Hadramaut in the beginning of the 6th century. Nearly at
the same period, Aëtius of Amida (the modern Diarbekir) used camphor
medicinally, but from the manner in which he speaks of it, it was
evidently a substance of some rarity.[1883]

In fact, for many centuries subsequent to this period, camphor was
regarded as one of the most rare and precious of perfumes. Thus, it is
mentioned in A.D. 636, with musk, ambergris, and snadal-wood, among the
treasures of Chosroes II., of the Sassanian dynasty of kings of Persia,
in the palace at Madain on the Tigris, north of Babylon.[1884]

Among the immense mass of valuables dispersed at Cairo on the downfall
of the Fatimite Khalif Mostanser in the 11th century, the Arabian
historians[1885] enumerate with astonishment, besides vast quantities
of musk, aloes wood, snadal-wood, amber, large stores of _Camphor of
Kaisur_, and hundreds of figures of _melons in camphor_, adorned with
gold and jewels, which were contained in precious vessels of gold and
porcelain. One grain (crystal?) of camphor is mentioned as weighing
5 mithkals, one melon of the weight of 70 mithkals, was contained
in a golden box weighing no less than 3,000 mithkals (1 mithkal =
71·49 gr. Troy = 4·63 grammes). It is also on record that about A.D.
642, Indian princes sent camphor as tribute or a gift to the Chinese
Emperors;[1886]—further, that in the Teenpaou period (A.D. 742-755),
the Cochinchinese brought to the Chinese court a tribute of Barus
camphor, said by the envoy to be found in the trunks of old trees, the
like of which for fragrance was never seen again.[1887] Masudi,[1888]
four centuries later, mentions a similar present from an Indian to
a Chinese potentate, when 1,000 _menn_[1889] of aloes-wood were
accompanied by 10 _menn_ of camphor, the choice quality of the latter
being indicated by the remark that it was in pieces as large or larger
than a pistachio-nut.

Again, between A.D. 1342 and 1352, an embassy left Pekin bearing a
letter from the Great Khan to Pope Benedict XII., accompanied by
presents of silk, precious stones, _camphor_, musk, and spices.[1890]

Ibn Batuta, the celebrated traveller, relates that after having visited
the King of Sumatra, he was presented on leaving (a.d. 1347) with
aloes-wood, _camphor_, cloves, and sandal-wood, besides provisions.

[1882] In the description of Arabia by Ibn Hagik el Hamdany, fol. 170
of the MS. at Aden (Prof. Sprenger).

[1883] He directs two ounces of camphor to be added to a certain
preparation, provided camphor is sufficiently abundant.—Tetr. iv. sermo
4. c. 114

[1884] G. Weil, _Geschichte der Chalifen_, i. (Mannheim, 1846) 75.

[1885] Quatremère, _Mém. sur l’Egypte_, ii. (1811) 366-375.—It is
interesting to find that _Káfúre-kaisúri_, i.e., _Kaisur Camphor_, is a
term still known in the Indian bazaars.

[1886] Käuffer, _Geschichte von Ostasien_, ii. (1859) 491.

[1887] Translation from the Chinese communicated by Mr. A. Wylie.

[1888] _Les Prairies d’or_, i. (Paris, 1861) 200.

[1889] The Arabian _menâ_ or _menn_ is equal to 2⅕ pounds Troy, or 933
grammes.

[1890] Yule, _Cathay and the way thither_, ii. 357.

Ishâk ibn Amrân, an Arabian physician living towards the end of the
9th century, and Ibn Khurdádbah, a geographer of the same period, were
among the first to point out that camphor is an export of the Malayan
Archipelago; and their statements are repeated by the Arabian writers
of the middle ages, who all assert that the best camphor is produced
in Fansúr. This place, also called Kansúr or Kaisúr, was visited in
the 13th century by Marco Polo, who speaks of its camphor as selling
for its weight in gold; Yule[1891] believes it to be the same spot as
Barus, a town on the western coast of Sumatra, still giving a name to
the camphor produced in that island.

From all these facts and many others that might be adduced,[1892] it
undoubtedly follows that the camphor first in use was that found native
in the trunk of the Sumatran _Dryobalanops aromatica_, and not that of
the Camphor Laurel. At what period and at whose instigation the Chinese
began to manufacture camphor from the latter tree is not known.

Camphor was known in Europe as a medicine as early as the 12th century,
as is evident from the mention of it by the abbess Hildegard[1893]
(who calls it _ganphora_), Otho of Cremona,[1894] and the Danish canon
Harpestreng (_ob._ A.D. 1244).

Garcia de Orta states (1563) that it is the camphor of China which
alone is exported to Europe, that of Borneo and Sumatra being a hundred
times more costly, and all consumed by eastern nations. They partly
devoted the latter to ritual purposes, as for instance embalming,
partly to “eating,” _i.e._ for the preparation of the betel-leaves for
chewing. Neuhof[1895] states that the other ingredients used in China
for that purpose are: Areca nuts (see article Semen Arecæ) and lime
or Lycium (see page 35), _Caphur de Burneo_, aloë (_i.e._ Aloë-wood,
see Aloë), and musk. Kämpfer,[1896] who resided in Japan in 1690-92,
and who figured the Japanese camphor tree under the name _Laurus
camphorifera_, expressly declares the latter to be entirely different
from the camphor tree of the Indian Archipelago. He further states
that the camphor of Borneo was among the more profitable commodities
imported into Japan by the Dutch, whose homeward cargoes included
Japanese camphor to the extent of 6,000 to 12,000 lb. annually.[1897]
This camphor was refined in Holland by a process long kept secret,
and was then introduced into the market. In Pomet’s time (1694 and
earlier), crude camphor was common in France, but it had to be sent to
Holland for purification.

It is doubtful whether at that period, or even much later, any camphor
was obtained from Formosa. Du Halde[1898] makes no allusion to it as a
production of that island; nor does he mention it among the commodities
of Emouy (Amoy), which was the Chinese port then in most active
communication with Formosa.

[1891] _The Book of Ser Marco Polo_, ii. (1874) 282, 285.

[1892] For further historical details, compare my paper in the
_Schweizerische Wochenschrift für Pharmacie_, 27 Sept., 4 and 11 Oct.
1867, or in Buchner’s _Repertorium f. Pharmacie_, xvii. (1868) 28.—F.
A. F.

[1893] S. Hildegardis _Opera Omnia_, accurante J. P. Migne, Paris,
1855. 1145.

[1894] Choulant, _Macer Floridus_, Lips. 1832. 161.

[1895] _Gesantschaft, etc._ Amsterdam, 1666. 363.

[1896] _Amœnitates exoticæ_ (1712) 770.

[1897] _Hist. of Japan_, translated by Scheuchzer, i. (1727) 353. 370.

[1898] _Description de la Chine_, i. (1735) 161.

=Production=—The camphor of European commerce is produced in the island
of Formosa and in Japan. We have no evidence that any is manufactured
at the present day in China, although very large trees, often from 8 to
9 feet in diameter, are common, for instance in Kiangsi, and camphor
wood is an important timber of the Hankow market.

In Formosa, the camphor-producing districts lie in the narrow belt of
debateable ground, which separates the border Chinese settlements from
the territory still occupied by the aboriginal tribes. The camphor is
prepared from the wood, which is cut into small chips from the trees,
by means of a gouge with a long handle. In this process there is
great waste, many trees being cut and then left with a large portion
of valuable timber to perish. The next operation is to expose the
wood to the vapour of boiling water, and to collect the camphor which
volatilizes with the steam. For this purpose, stills are constructed
thus:—a long wooden trough, frequently a hollowed trunk, is fixed over
a furnace and protected by a coating of clay. Water is poured into it,
and a board perforated with numerous small holes is luted over it.
Above these holes the chips are placed and covered with earthen pots.
A fire having been lighted in the furnace, the water becomes heated,
and the steam passing through the chips, carries with it the camphor,
which condenses in minute white crystals in the upper part of the pots.
From these it is scraped out every few days, and is then very pure
and clean. Four stills, each having ten pots placed in a row over one
trough, are generally arranged under one shed. These stills are moved
from time to time, according as the gradual exhaustion of timber in the
locality renders such transfer desirable. A considerable quantity of
camphor is however manufactured in the towns, the chips being conveyed
thither from the country. A model of a much better still, which was
contributed from Formosa to the Paris Exhibition in 1878, is perhaps
referring to a town manufacture.

Camphor is brought from the interior to Tamsui, the chief port of
Formosa, the baskets holding about half a pecul each (1 pecul = 133⅓
lbs.), lined and covered with large leaves. Upon arrival, it is stored
in vats holding from 50 to 60 peculs each, or it is packed at once
in the tubs, or lead-lined boxes, in which it is exported. From the
vats or tubs there drains out a yellowish essential oil known as
_Camphor Oil_, which is used by the Chinese in rheumatism.[1899] In
1877 hydraulic pressure has been established for the separation of the
oil and moisture; the raw camphor loses about 20 per cent. of these
admixtures.

Kämpfer in his account[1900] of the manufacture of camphor in the
Japanese province of Satzuma and in the islands of Gotho, describes
the boiling of the chips in an iron pot covered with an earthen head
containing straw in which the camphor collects. In the province of
Tosa, island of Sikok, there is now a still in use, which is quite
conveniently combined with a cooling apparatus consisting of a wooden
trough, over which cold water is flowing.[1901]

[1899] The foregoing particulars are chiefly extracted from the _Trade
Report of Tamsui_ by E. C. Taintor, Acting Commissioner of Customs,
published in the _Reports on Trade at the Treaty Ports in China_ for
1869, Shanghai, 1870, and from James Morrison’s _Description of the
island of Formosa_, in the _Geogr. Magazine_, 1877, 263 and 319.

[1900] _op. cit._ p. 772.

[1901] Both of the above mentioned stills from Sikok and Formosa
are figured in my “_Account of the Paris Exhibition_,” _Archiv der
Pharmacie_, 214 (1879) 12.—F. A. F..

=Purification=—Camphor as it is exported from Japan and Formosa
requires to be purified by sublimation. The crude drug consists of
small crystalline grains, which cohere into irregular friable masses,
of a greyish-white or pinkish hue. Dissolved in spirit of wine, it
leaves from 2 to 10 per cent. of impurities consisting of gypsum,
common salt, sulphur, or vegetable fragments.

In Europe, crude camphor is sublimed from a little charcoal or sand,
iron filings or quicklime, and sent into the market as _Refined
Camphor_ in the form of large bowls or concave cakes, about 10
inches in diameter, 3 inches in thickness, and weighing from 9 to 12
lb.[1902] Each bowl has a large round hole at the bottom, corresponding
to the aperture of the vessel in which the sublimation has been
conducted. This operation is performed in peculiar glass flasks termed
_bomboloes_, in the upper half of which the pure camphor concretes.
These flasks having been charged and placed in a sand-bath, are rapidly
heated to about 120°-190° C. in order to remove the water. Afterwards
the temperature is slowly increased to about 204° C., and maintained
during 24 hours. The flasks are finally broken.

As camphor is a neutral substance, the addition of lime probably serves
merely to retain traces of resin or empyreumatic oil. Iron would keep
back sulphur were any present.

In the United States the refiners use iron vessels; their product is in
flat disks, about 16 inches in diameter by one inch in thickness.

The refining of camphor is carried on to a large extent in England,
Holland, Hamburg, Paris, Bohemia (Aussig), in New York and
Philadelphia. It is a process requiring great care on account of the
inflammability of the product. The temperature must also be nicely
regulated, so that the sublimate may be deposited not merely in loose
crystals, but in compact cakes. In India where the consumption of
camphor is very large, the natives effect the sublimation in a copper
vessel, the charge of which is 1½ maunds (42 lb.): fire is applied to
the lower part, the upper being kept cool.[1903]

=Description=—Purified Camphor forms a colourless crystalline,
translucent mass, traversed by numerous fissures, so that
notwithstanding a certain toughness, a mass can readily be broken
by repeated blows. By spontaneous and extremely slow evaporation at
ordinary temperatures, camphor sublimes in lustrous hexagonal plates or
prisms, having but little hardness. If triturated in a mortar, camphor
adheres to the pestle, so that it cannot be powdered _per se_. But if
moistened with spirit of wine, ether, chloroform, methylic alcohol,
glycerin, or an essential or fatty oil, pulverization is effected
without difficulty. By keeping a short time, the powder acquires a
crystalline form. With an equal weight of sugar, camphor may also be
easily powdered.

Camphor melts at 175° C., boils at 204°, and volatilizes somewhat
rapidly even at ordinary temperatures. To this latter property,
combined with slight solubility, must be attributed the curious
rotatory motion which small lumps of camphor (as well as barium
butyrate, stannic bromide, chloral hydrate, and a few other substances)
exhibit when thrown on to water.

[1902] These are the dimensions of the cakes manufactured in the
laboratory of Messrs. Howards of Stratford, but it is obvious that they
may vary with different makers.

[1903] Mattheson, _England to Delhi_, Lond. 1870, 474.

The solubility of camphor in water is very small, 1300 parts dissolving
about one; but even this small quantity is partially separated on
addition of some alkaline or earthy salt, as sulphate of magnesium.
Alcohols, ethers, chloroform, carbon bisulphide, volatile and fixed
oils and liquid hydrocarbons, dissolve camphor abundantly.

The sp. gr. of camphor at 0° C. and up to 6° is the same as that of
water; yet at a somewhat higher temperature, camphor expands more
quickly, so that at 10° to 12° C. its sp. gr. is only 0·992.

In concentrated solution or in a state of fusion, camphor turns the
plane of polarization strongly to the right. Officinal solution of
camphor (_Spiritus Camphoræ_) is too weak, and does not deviate the ray
of light to a considerable amount.[1904] Crystals of camphor are devoid
of rotatory power.

The taste and odour of camphor are _sui generis_, or at least are
common only to a group of nearly allied substances. Camphor is not
altered by exposure to air or light. It burns easily, affording a
brilliant smoky flame.

=Chemical Composition=—Camphor, C₁₀H₁₆O, by treatment with various
reagents, yields a number of interesting products: thus when repeatedly
distilled with chloride of zinc or anhydrous phosphoric acid, it is
converted into _Cymene_ or _Cymol_, C₁₀H₁₄, a body contained in many
essential oils, or obtainable therefrom.

Camphor, and also camphor oil, when subjected to powerful oxidizing
agents, absorbs oxygen, passing gradually into crystallized _Camphoric
Acid_, C₁₀H₁₆O₄ or C₈H₁₄(COOH)₂, water and carbonic acid being at
the same time eliminated. Many essential oils, resins and gum-resins
likewise yield these acids when similarly treated.

By means of less energetic oxidizers, camphor may be converted into
_Oxy-Camphor_, C₁₀H₁₆O₂, still retaining its original odour and taste
(Wheeler, 1868).

=Commerce=—Two kinds of crude camphor are known in the English market,
namely:

1. _Formosa_ or _China Camphor_, imported in chests lined with lead or
tinned iron, and weighing about 1 cwt. each; it is of a light brown,
small in grain, and always wet, as the merchants cause water to be
poured into the cases before shipment, with a view, it is pretended,
of lessening the loss by evaporation. The exports of this camphor from
Tamsui in Formosa[1905] were in peculs (one pecul = 13·33 lb. avdp. =
60·479 kilogrammes) as follows:

     1870    1871    1872    1875   1876    1877
    14,481   9691   10,281   7139   8794   13,178

The shipments of camphor from Takow, the other open port of Formosa,
are of insignificant amount. Planks of camphor wood are now exported in
some quantity from Tamsui.

2. _Japan Camphor_ is lighter in colour and occasionally of a pinkish
tint; it is also in larger grains. It arrives in double tubs (one
within the other) without metal lining, and hence is drier than the
previous sort; the tubs hold about 1 cwt. It fetches a somewhat higher
price than the Formosa camphor.

[1904] _Pharm. Journ._ 18 April 1874. 830.

[1905] _Returns of Trade at the Treaty Ports in China for 1872_, part.
2, p. 124.

Hiogo and Osaka exported in 1871, 7089 peculs (945,200 lb.), and
Nagasaki 745 peculs (99,333 lb.), the total value being 116,718
dollars.[1906] In 1877 the value of camphor exported from Japan was
stated to be equal to 240,000 dollars. The imports of _Unrefined
Camphor_ into the United Kingdom amounted in 1870 to 12,368 cwt.
(1,385,216 lb.); of _Refined Camphor_ in the same year to 2361
cwt.[1907]

Camphor is largely consumed by the natives of India; the quantity
of the crude drug imported into Bombay in the year 1872-73 was 3801
cwt.[1908]

=Uses=—Camphor has stimulant properties and is frequently used in
medicine both internally and externally. It is largely consumed in
India.

Other kinds of Camphor; Camphor Oils.

Camphor, as stated above at page 512, was the name originally applied
to the product of Dryobalanops; it was then also given to that of
Camphor Laurel, and in 1725 Caspar Neumann, of Berlin, first pointed
out that many essential oils afford crystals (“stearoptenes” of later
chemists), for which he proposed the general name of camphor. Many of
them are agreeing with the formula C₁₀H₁₆O, and there are also numerous
liquids of the same composition. It would appear, however, that no
stearoptene of any other plant is absolutely identical with common
camphor; Lallemand’s statement (see p. 479), that oil of spike affords
the latter, requires further examination.

Many other liquid and solid constituents of essential oils, or
substances afforded by treating them with alcoholic potash, answer to
the formula C₁₀H₁₇(OH). Among them we may point out the two following:
they are the only substances of the class of “camphors,” besides common
camphor, which are of some practical importance.

_Barus Camphor, Borneo Camphor, Malayan Camphor, Dryobalanops
Camphor_—This, as already explained, is the substance to which
the earliest notices of camphor refer. The tree which affords it
is _Dryobalanops aromatica_ Gärtn. (_D. Camphora_ Colebrooke), of
the order _Dipterocarpeæ_, one of the most majestic objects of the
vegetable kingdom.[1909] The trunk is very tall, round, and straight,
furnished near the base with huge buttresses; it rises 100 to 150 feet
without a branch, then producing a dense crown of shining foliage, 50
to 70 feet in diameter, on which are scattered beautiful white flowers
of delicious fragrance. The tree is indigenous to the Dutch Residencies
on the north-west coast of Sumatra, between 0° and 3° N. lat., from
Ayer Bangis to Barus and Singkel, and to the northern part of Borneo,
and the small British island of Labuan.

[1906] _Commercial Reports from H. M. Consuls in Japan_, No. 1,
1872.—The returns for Hiogo and Osaka are upon the authority of the
Chamber of Commerce.

[1907] _Statement of the Trade and Navigation of the United Kingdom_
for 1870. p. 61—no later returns accessible.

[1908] _Statement of the Trade and Navigation of Bombay for 1872-73._
ii. 27.

[1909] For a full account and figure of it, see W. H. de Vriese’s
excellent _Mémoire sur le Camphrier de Sumatra et de Bornéo_, Leide,
1857. 23 p. 4°. and 2 plates.

The camphor is obtained from the trunk, in longitudinal fissures of
which it is found in a solid crystalline state, and extracted by
laboriously splitting the wood. It can only be got by the destruction
of the entire tree;—in fact, many trees afford none, so that to avoid
the toil of useless felling, it is now customary to try them by cutting
a hole in the side of the trunk, but the observation so made is often
fallacious. Spenser St. John, British Consul in Borneo, was told that
trees in a state of decay often contain the finest camphor.[1910] The
camphor when collected is carefully picked over, washed and cleaned,
and then separated into three qualities, the best being formed of
the largest and purest crystals, while the lowest is greyish and
pulverulent.

Dryobalanops attaining more than 150 feet in height, the quantity of
camphor which it yields must necessarily be greatly variable. The
statements are from about 3 to 11 lb.

A good proportion of the small quantity produced is consumed in the
funeral rites of the Batta princes, whose families are often ruined by
the lavish expense of providing the camphor and buffaloes which the
custom of their obsequies requires. The camphor which is exported is
eagerly bought for the China market, but some is also sent to Japan,
Laos, Cochin China, Cambodia, and Siam.

The quantity annually shipped from Borneo was reckoned by Motley in
1851 to be about 7 peculs (933 lbs.). The export from Sumatra was
estimated by De Vriese at 10 to 15 quintals per annum.[1911] The
quantity imported into Canton in 1872 was returned as 23⁷/₁₀ peculs
(3,159 lb.), value 42,326 taels, equivalent to about 80_s._ per
lb.[1912] In the _Annual Statement of the Trade of Bombay_ for the year
1872-3, 2 cwt. of _Malayan Camphor_ is stated to have been imported;
it was valued at 9,141 Rs. (£914). In the “Indian tariff,” 1875, the
duty is fixed _per cwt._ at 40 rupees for crude camphor, 65 rupees
for refined camphor, and 80 rupees _per pound_ for Baros camphor
(“Bhemsaini camphor”). The price in Borneo in 1851 of camphor of fine
quality was 30 dollars per catty, or about 95_s._ per lb.: consequently
the drug never finds its way into European commerce.

[1910] _Life in the Forests of the Far East_, ii. (1862) 272.

[1911] In Milburn’s time (_Oriental Commerce_, ii. 1813. 308), Sumatra
was reckoned to export 50 peculs, and Borneo 30 peculs a year. Rondot’s
statement (see Cassia Buds) that China imports of Barus camphor about
800 peculs annually is plainly erroneous.

[1912] _Returns of Trade at the Treaty Ports in China for 1872_, p. 30.

Borneo Camphor, also termed by chemists _Borneol_ or _Camphyl Alcohol_,
is somewhat harder than common camphor, also a little heavier so that
it sinks in water. It is less volatile, and does not crystallize on the
interior of the bottle in which it is kept; and it requires for fusion
a higher temperature, namely 198° C. It has a somewhat different odour,
resembling that of common camphor with the addition of patchouli or
ambergris. The composition of borneol is represented by the formula
C₁₀H₁₇(OH). It may be converted by the action of nitric acid into
common camphor, which it nearly resembles in most of its physical
properties. Conversely, borneol may also be prepared from common
camphor. By continued oxydation borneol yields camphoric acid.

_Camphor Oil of Borneo_—Besides camphor, the _Dryobalanops_ furnishes
another product, a liquid termed _Camphor Oil_, which must not be
confounded with the camphor oil that drains out of crude laurel
camphor. This Bornean or Sumatran _Camphor Oil_ is obtained by
tapping the trees, or in felling them (see also p. 229). In the latter
way, Motley in cutting down a tree in Labuan in May, 1851, pierced a
reservoir in the trunk from which about five gallons of camphor oil
were obtained, though much could not be caught.[1913] The liquid was
a volatile oil holding in solution a resin, which after a few days’
exposure to the air, was left in a syrupy state. This camphor oil,
which is termed _Borneene_, is isomeric with oil of turpentine, C₁₀H₁₆,
yet in the crude state holding in solution borneol and resin. By
fractional distillation, it may be separated into two portions, the one
more volatile than the other but not differing in composition.

_Camphor Oil of Formosa_, which has been already referred to as
draining out of the crude camphor of _Cinnamomum Camphora_, is a brown
liquid holding in solution an abundance of common camphor, which it
speedily deposits in crystals when the temperature is slightly reduced.
From Borneo Camphor Oil it may be distinguished by its _odour of
sassafras_. We find no optical difference in the rotatory power of the
oils; both are dextrogyre to the same extent, which is still the case
if the camphor from the lauraceous camphor oil is separated by cooling.
Borneo camphor oil, for a sample of which we are indebted to Prof. de
Vriese, deposits no camphor even when kept at -15° C.

_Ngai Camphor, Blumea Camphor_—It has been known for many years that
the Chinese are in the habit of using a third variety of camphor,
having a pecuniary value intermediate between that of common camphor
and of Borneo camphor. This substance is manufactured at Canton and
in the island of Hainan, the plant from which it is obtained being
_Blumea balsamifera_ DC., a tall herbaceous _Composita_, of the tribe
_Inuloideæ_, called in Chinese _Ngai_, abundant in Tropical Eastern
Asia.

The drug has been supplied to us[1914] in two forms,—crude and
pure,—the first being in crystalline grains of a dirty white,
contaminated with vegetable remains; the second in colourless crystals
as much as an inch in length. By sublimation the substance may be
obtained in distinct, brilliant crystals, agreeing precisely with those
of Borneo camphor, which they also resemble in odour and hardness, as
well as in being a little heavier than water and not so volatile as
common camphor.

The chemical examination of Ngai camphor, performed by Plowman,[1915]
under the direction of Prof. Attfield, has proved that it has the
composition C₁₀H₁₈O, like Borneo camphor. But the two substances differ
in optical properties,[1916] an alcoholic solution of Ngai camphor
being _levogyre_ in about the same degree that one of Borneo camphor
is _dextrogyre_. By boiling nitric acid, Borneo camphor is transformed
into common (_dextrogyre_) camphor, whereas Ngai camphor affords a
similar yet _levogyre_ camphor, in all probability identical with the
stearoptene of _Chrysanthemum Parthenium_ Pers.

As Ngai camphor is about ten times the price of Formosa camphor, it
never finds its way to Europe as an article of trade. In China it is
consumed partly in medicine and partly in perfuming the fine kinds of
Chinese ink. The export of this camphor by sea from Canton is valued at
about £3,000 a year; it is also exported from Kiung-chow, in the island
of Hainan.

[1913] Ibn Khurdádbah in the 9th century mentions it as being obtained
in this way.

[1914] Through the courtesy of Mr. F. H. Ewer, of the Imperial Maritime
Customs, Canton.—Hanbury, _Science Papers_, 189. 393.

[1915] _Pharm. Journ._ March 7, 1874. 710.

[1916] Flückiger in _Pharm. Journ._ April 18, 1874. 829.


CORTEX CINNAMOMI.

_Cortex Cinnamomi Zeylanici_; _Cinnamon_; F. _Cannelle de Ceylan_; G.
_Zimmt_, _Ceylon Zimmt_, _Kaneel_.

=Botanical Origin=—_Cinnamomum zeylanicum_ Breyne,—a small evergreen
tree, richly clothed with beautiful, shining leaves usually somewhat
glaucous beneath, and having panicles of greenish flowers of
disagreeable odour.

It is a native of Ceylon, where, according to Thwaites, it is generally
distributed through the forests up to an elevation of 3,000 feet, and
one variety even to 8,000 feet. It is exceedingly variable in stature,
and in the outline, size and consistence of the leaf; and several
of the extreme forms are very unlike one another and have received
specific names. But there are also numerous intermediate forms; and
in a large suite of specimens, many occur of which it is impossible
to determine whether they should be referred to this species or to
that. Thwaites[1917] is of opinion that some still admitted species,
as _C. obtusifolium_ Nees and _C. iners_ Reinw., will prove on further
investigation to be mere forms of _C. zeylanicum_.

Beddome,[1918] Conservator of Forests in Madras, remarks that in the
moist forests of South-western India there are 7 or 8 well-marked
varieties which might easily be regarded as so many distinct species,
but for the fact that they are so connected _inter se_ by intermediate
forms, that it is impossible to find constant characters worthy of
specific distinction. They grow from the sea-level up to the highest
elevations, and, as Beddome thinks, owe their differences chiefly to
local circumstances, so that he is disposed to class them simply as
forms of _C. zeylanicum_.

=History=—(For that of the essential oil of cinnamon see page 526).
Cinnamon was held in high esteem in the most remote times of history.
In the words of the learned Dr. Vincent, Dean of Westminster,[1919]
it seems to have been the first spice sought after in all oriental
voyages. Both cinnamon and cassia are mentioned as precious odoriferous
substances in the Mosaic writings and in the Biblical books of Psalms,
Proverbs, Canticles, Ezekiel and Revelations, also by Theophrastus,
Herodotus, Galen, Dioscorides, Pliny, Strabo and many other writers of
antiquity: and from the accounts which have thus come down to us, there
appears reason for believing that the spices referred to were nearly
the same as those of the present day. That cinnamon and cassia were
extremely analogous, is proved by the remark of Galen, that the finest
cassia differs so little from the lowest quality of cinnamon, that the
first may be substituted for the second, provided a double weight of it
be used.

[1917] _Enumeratio Plantarum Zeylaniæ_, 1864. 252.—Consult also
Meissner in De Cand. _Prod._ xv. sect. i. 10.

[1918] _Flora Sylvatica for Southern India_, 1872. 262.

[1919] _Commerce and Navigation of the Ancients in the Indian Ocean_,
ii. (1807) 512.

It is also evident that both were regarded as among the most costly
of aromatics, for the offering made by Seleucus II. Callinicus, king
of Syria, and his brother Antiochus Hierax, to the temple of Apollo
at Miletus, B.C. 243, consisting chiefly of vessels of gold and
silver, and olibanum, myrrh (σμύρνη), costus (page 382), included also
two pounds of _Cassia_ (κασία), and the same quantity of _Cinnamon_
(κιννάμωμον).[1920]

In connexion with this subject there is one remarkable fact to be
noticed, which is that none of the cinnamon of the ancients was
obtained from Ceylon. “In the pages of no author,” says Tennent,[1921]
“European or Asiatic, from the earliest ages to the close of the
thirteenth century, is there the remotest allusion to cinnamon as an
indigenous production, or even as an article of commerce in Ceylon.”
Nor do the annuals of the Chinese, between whom and the inhabitants
of Ceylon, from the 4th to the 8th centuries, there was frequent
intercourse and exchange of commodities, name _Cinnamon_ as one of the
productions of the island. The Sacred Books and other ancient records
of the Singhalese are also completely silent on this point.

Cassia, under the name of _Kwei_, is mentioned in the earliest Chinese
herbal,—that of the emperor Shen-nung, who reigned about 2700 B.C., in
the ancient Chinese[1922] Classics, and in the _Rh-ya_, a herbal dating
from 1200 B.C. In the _Hai-yao-pên-ts’ao_, written in the 8th century,
mention is made of _Tien-chu kwei_. Tien-chu is the ancient name for
India: perhaps the allusion may be to the cassia bark of Malabar.

In connexion with these extremely early references to the spice, it may
be stated that a bark supposed to be _cassia_ is mentioned as imported
into Egypt together with gold, ivory, frankincense, precious woods, and
apes, in the 17th century B.C.[1923]

The accounts given by Dioscorides, Ptolemy and the author of the
Periplus of the Erythrean Sea, indicate that cinnamon and cassia were
obtained from Arabia and Eastern Africa; and we further know that the
importers were Phœnicians, who traded by Egypt and the Red Sea with
Arabia. Whether the spice under notice was really a production of
Arabia or Africa, or whether it was imported thither from Southern
China (the present source of the best sort of cassia), is a question
which has excited no small amount of discussion.

We are in favour of the second alternative,—firstly, because no
substance of the nature of cinnamon is known to be produced in Arabia
or Africa; and secondly, because the commercial intercourse which
was undoubtedly carried on by China with India and Arabia, and which
also existed between Arabia, India and Africa, is amply sufficient to
explain the importation of Chinese produce.[1924] That the spice was a
production of the far East is moreover implied by the name _Darchini_
(from _dar_, wood or bark, and _Chini_, Chinese) given to it by the
Arabians and Persians.

[1920] Chishull, _Antiquities Asiaticæ_, 1728. 65-72.

[1921] _Ceylon_, i (1859) 575.

[1922] We are indebted to Dr. Bretschneider of Pekin for these
references to Chinese literature. For information about some of the
works quoted, see his pamphlet _On the Study and Value of Chinese
Botanical Works_, Foochow, 1870.

[1923] Dümichen, _Fleet of an Egyptian Queen_, Leipzig, 1868, p. 1.

[1924] “ ... That there was an ulterior commerce beyond Ceylon is
indubitable; for at Ceylon the trade from Malacca and the Golden
Chersonese met the merchants from Arabia, Persia and Egypt. This might
possibly have been in the hands of the Malays or even the Chinese,
who seem to have been navigators in all ages as universally as the
Arabians....” Vincent, _op. cit._ ii. 284. 285.—In the time of Marco
Polo, the trade of China westward met the trade of the Red Sea, no
longer in Ceylon, but on the coast of Malabar, apparently at Calicut,
where the Portuguese found it on their first arrival. Here, says Marco,
the ships from Aden obtained their lading from the East, and carried it
into the Red Sea for Alexandria, whence it passed into Europe by means
of the Venetians.—See also Yule, _Book of Ser Marco Polo_, ii. (1871)
325, 327.

If this view of the case is admissible, we must regard the ancient
cinnamon to have been the substance now known as _Chinese Cassia
lignea_ or _Chinese Cinnamon_, and cassia as one of the thicker and
perhaps less aromatic barks of the same group, such in fact as are
still found in commerce.

Of the circumstances which led to the collection of cinnamon in Ceylon,
and of the period at which it was commenced, nothing is known. That
the Chinese were concerned in the discovery is not an unreasonable
supposition, seeing that they traded to Ceylon, and were in all
probability acquainted with the cassia-yielding species of _Cinnamomum_
of Southern China, a tree extremely like the cinnamon tree of Ceylon.

Whatever may be the facts, the early notices of cinnamon as a
production of Ceylon are not prior to the 13th century. The very first,
according to Yule,[1925] is a mention of the spice by Kazwini, an Arab
writer of about A.D. 1275, very soon after which period it is noticed
by the historian of the Egyptian Sultan Kelaoun, A.D. 1283. The prince
of Ceylon is stated to have sent an ambassador, Al-Hadj-Abu-Othman, to
the Sultan’s court. It was mentioned that Ceylon produced elephants,
Bakam (the wood of _Cæsalpinia Sapan_ L.—see page 216), pearls and also
_cinnamon_.[1926]

A still more positive evidence is due to the Minorite friar, John of
Montecorvino, a missionary who visited India. This man, in a letter
under date December 20th, 1292 or 1293, written at “Mabar, città dell’
India di sopra,” and still extant in the Medicean library at Florence,
says that the cinnamon tree is of medium bulk, and in trunk, bark and
foliage, like a laurel, and that great store of its bark is carried
forth from the island which is near by Malabar.[1927]

Again, it is mentioned by the Mahomedan traveller Ibn Batuta about A.D.
1340,[1928] and a century later by the Venetian merchant Nicolo di
Conti, whose description of the tree is very correct.[1929]

The circumnavigation of the Cape of Good Hope led to the real discovery
of Ceylon by the Portuguese in 1505, and to their permanent occupation
of the island in 1536, chiefly for the sake of the cinnamon. It is from
the first of these dates that more exact accounts of the spice began to
reach Europe. Thus in 1511 Barbosa distinguished the fine cinnamon of
Ceylon from the inferior _Canella trista_ of Malabar. Garcia de Orta,
about the middle of the same century, stated that Ceylon cinnamon was
forty times as dear as that of Malabar. Clusius, the translator of
Garcia, saw branches of the cinnamon tree as early as 1571 at Bristol
and in Holland.

[1925] _Marco Polo_, ii. 255.

[1926] _Quatremère_ (in the book quoted at page 511, note 4), ii. 284.

[1927] Yule, _Cathay and the way thither_, i. 213, also Kunstmann,
_Anzeigen der baierischen Akademie_, 24 and 25 December 1855. p. 163
and 169.

[1928] _Travels of Ibn Batuta_, translated by Lee, Lond. 1829. 184.

[1929] Ramusio, _Raccolta delle Navigationi et Viaggi_, i. (1563) 339;
Kunstmann, _Kenntniss Indiens im fünfzehnten Jahrhundert_, 1864. 39.

At this period cinnamon was cut from trees growing wild in the forests
in the interior of Ceylon, the bark being exacted as tribute from the
Singhalese kings by the Portuguese. A peculiar caste called _chalias_,
who are said to have emigrated from India to Ceylon in the 13th
century, and who in after-times became cinnamon-peelers, delivered the
bark to the Portuguese. The cruel oppression of these _chalias_ was not
mitigated by the Dutch, who from the year 1656 were virtually masters
of the whole seaboard, and conceded the cinnamon trade to their East
India Company as a profitable monopoly, which the Company exercised
with the greatest severity.[1930] The bark previous to shipment was
minutely examined by special officers, to guard against frauds on the
part of the _chalias_.

About 1770 De Koke conceived the happy idea, in opposition to the
universal prejudice in favour of wild-growing cinnamon, of attempting
the cultivation of the tree. This project was carried out under
Governors Falck and Van der Graff with extraordinary success, so that
the Dutch were able, independently of the kingdom of Kandy, to furnish
about 400,000 lb. of cinnamon annually, thereby supplying the entire
European demand. In fact, they completely ruled the trade, and would
even _burn_ the cinnamon in Holland, lest its unusual abundance should
reduce the price.

After Ceylon had been wrested from the Dutch by the English in 1796,
the cinnamon trade became the monopoly of the English East India
Company, who then obtained more cinnamon from the forests, especially
after the year 1815, when the kingdom of Kandy fell under British rule.
But though the _chalias_ had much increased in numbers, the yearly
production of cinnamon does not appear to have exceeded 500,000 lb. The
condition of the unfortunate _chalias_ was not ameliorated until 1833,
when the monopoly granted to the Company was finally abolished, and
Government, ceasing to be the sole exporters of cinnamon, permitted the
merchants of Colombo and Galle to share in the trade.

Cinnamon however was still burdened with an export duty equal to a
third or a half of its value; in consequence of which and of the
competition with cinnamon raised in Java, and with cassia from China
and other places, the cultivation in Ceylon began to suffer. This duty
was not removed until 1853.

The earliest notice of cinnamon in connexion with Northern Europe that
we have met with, is the diploma granted by Chilperic II., king of the
Franks, to the monastery of Corbie in Normandy, A.D. 716, in which
provision is made for a certain supply of spices and grocery, including
5 lb. of _Cinnamon_.[1931]

The extraordinary value set on cinnamon at this period is remarkably
illustrated by some letters written from Italy, in which mention
is here and there incidentally made of presents of spices and
incense.[1932] Thus in A.D. 745, Gemmulus, a Roman deacon, sends to
Boniface, archbishop of Mayence (“_cum magnâ reverentiâ_”), 4 ounces
of _Cinnamon_, 4 ounces of Costus, and 2 pounds of Pepper. In A.D.
748, Theophilacias, a Roman archdeacon, presents to the same bishop
similar spices and incense. Lullus, the successor of Boniface, sends to
Eadburga, _abbatissa Thanetensis_,[1933] _circa_ A.D. 732-751—“_unum
graphium argenteum et storacis et_ cinnamomi _partem aliquam_”; and
about the same date, another present of cinnamon to archbishop Boniface
is recorded. Under date A.D. 732-742, a letter is extant of three
persons to the abbess Cuneburga, to whom the writers offer—“_turis et
piperis et_ cinnamomi _permodica xenia, sed omni mentis affectione
destinata_.”

[1930] Tennent, _op. cit._ ii. 52.

[1931] Pardessus, _Diplomata_, etc., Paris, 1849. ii. 309.

[1932] Jaffé, _Bibliotheca Rerum Germanicarum_, Berlin, iii. (1866)
154. 199. 214. 216-8. 109.

[1933] Doubtless _Eadburh_, third abbess of Minster in the Isle of
Thanet in Kent. She died A.D. 751.

In the 9th century, _Cinnamon_, pepper, costus, cloves, and several
indigenous aromatic plants were used in the monastery of St. Gall in
Switzerland as ingredients for seasoning fish.[1934]

Of the pecuniary value of this spice in England, there are many notices
from the year 1264 downwards.[1935] In the 16th century it was probably
not plentiful, if we may judge from the fact that it figures among the
New Year’s gifts to Philip and Mary (1556-57), and to Queen Elizabeth
(1561-62).[1936]

=Production and Commerce=[1937]—The best cinnamon is produced,
according to Thwaites,[1938] from a cultivated or selected form of the
tree (var. α.), distinguished by large leaves of somewhat irregular
shape. But the bark of all the forms possesses the odour of cinnamon
in a greater or less degree. It is not however always possible to
judge of the quality of the bark from the foliage, so that the peelers
when collecting from uncultivated trees, are in the habit of tasting
the bark before commencing operations, and pass over some trees as
unfit for their purpose. The bark of varieties β. _multiflorum_ and
γ. _ovalifolium_ is of very inferior quality, and said to be never
collected unless for the purpose of adulteration.

The best variety appears to find the conditions most favourable to
its culture, in the strip of country, 12 to 15 miles broad, on the
south-west coast of Ceylon, between Negumbo, Colombo and Matura,
where the tree is grown up to an elevation of 1500 feet. A very
sandy clay soil, or fine white quartz, with a good sub-soil and free
exposure to the sun and rain, are the circumstances best adapted for
the cultivation. The management of the plantations resembles that of
oak coppice in England. The system of pruning checks the plant from
becoming a tree, and induces it to form a stool from which four or five
shoots are allowed to grow; these are cut at the age of 1½ to 2 years,
when the greyish-green epidermis begins to turn brown by reason of the
formation of a corky layer. They are not all cut at the same time, but
only as they arrive at the proper state of maturity; they are then 6 to
10 feet high and 1 to 2 inches thick. In some of the cinnamon gardens
at Colombo, the stools are very large and old, dating back, it is
supposed, from the time of the Dutch.

[1934] _Pharm. Journ._ viii. (1877) 121.

[1935] Eden, _State of the Poor_, ii. (1797) appendix; Rogers, _Hist.
of Agriculture and Prices in England_, ii. (1866) 543.

[1936] Nicholls, _Progresses and Processions of Q. Elizabeth_, i.
(1823) xxxiv. 118.

[1937] Additional information may be found in two papers by Marshall,
in Thomson’s _Annals of Philosophy_, x. (1817) 241 and 346; see also
Leschenault de la Tour, _Mém. du Musée d’Hist. nat._ viii. (1822)
436-446.

[1938] _Op. cit._ 252-253.

In consequence of the increased flow of sap which occurs after the
heavy rains in May and June, and again in November and December, the
bark at those seasons is easily separated from the wood, so that a
principal harvest takes place in the spring, and a smaller one in the
latter part of the year.

The shoots having been cut off by means of a long sickle-shaped hook
called a _catty_, and stripped of their leaves, are slightly trimmed
with a knife, the little pieces thus removed being reserved and sold as
_Cinnamon Chips_. The bark is next cut through at distances of about
a foot, and slit lengthwise, when it is easily and completely removed
by the insertion of a peculiar knife termed a _mama_, the separation
being assisted, if necessary, by strongly rubbing with the handle. The
pieces of bark are now carefully put one into another, and the compound
sticks firmly bound together into bundles. Thus they are left for 24
hours or more, during which a sort of “_fermentation_” (?) goes on
which facilitates the subsequent removal part. This is accomplished
by placing each quill on a stick of wood of suitable thickness, and
carefully scraping off with a knife the outer and middle cortical
layer. In a few hours after this operation, the peeler commences to
place the smaller tubes within the larger, also inserting the small
pieces so as to make up an almost solid stick, of about 40 inches in
length. The cinnamon thus prepared is kept one day in the shade, and
then placed on wicker trays in the sun to dry. When sufficiently dry,
it is made into bundles of about 30 lb. each.[1939]

The cinnamon gardens of Ceylon were estimated in 1860-64 to occupy an
area of about 14,400 acres; in the catalogue of the British Colonies,
Paris Exhibition, 1878, about 2 millions of acres are stated to be
under cultivation in the island, 26,000 acres with cinnamon.[1940]

The exports of cinnamon from Ceylon have been as follows:—

       1871             1872             1875
    1,359,327 lb.,   1,267,953 lb.,   1,500,000 lb.
    value £67,966.   value £64,747.

At present the cultivation of coffee is displacing that of cinnamon,
the exports of the former in 1875 being 928,606 cwts. valued at 4¼
millions sterling. Of the crop of 1872 there were 1,179,516 lb. of
cinnamon shipped to the United Kingdom, 53,439 lb. to the United States
of North America, and 10,000 lb. to Hamburg.

Besides the above-named exports of cinnamon, the official
statistics[1941] record the export of “_Cinnamon Bark_”—8846 lb. in
1871—23,449 lb. in 1872. This name includes two distinct articles,
namely _Cinnamon Chips_, and a very thick bark derived from old stems.
The _Cinnamon Chips_ which, as explained on the previous page, are
the first trimmings of the shoots, are very aromatic; they used to
be considered worthless, and were thrown away. The second article,
to which in the London drug sales the name “_Cinnamon Bark_” is
restricted, is in flat or slightly channelled fragments, which are as
much as ⁴/₁₀ of an inch in thickness, and remind one of New Granada
cinchona bark. It is very deficient in aromatic qualities, and quite
unfit for use in pharmacy.

[1939] Formerly called _fardela_ or _fardello_, a name signifying in
the Romance languages _bundle_ or _package_. The word _fardel_, having
the same meaning, is found in old English writers.

[1940] Yet the cultivation was far more extensive in the earlier
part of the century, as we may judge by the statement that the five
principal cinnamon gardens around Negumbo, Colombo, Barberyn, Galle,
and Matura, were _each from 15 to 20 miles in circumference_ (Tennent’s
_Ceylon_, ii. 163).

[1941] _Ceylon Blue Books_ for 1871 and 1872, printed at Colombo.

In most other countries into which _Cinnamomum zeylanicum_ has been
transplanted, it has been found that, partly from its tendency to pass
into new varieties and partly perhaps from want of careful cultivation
and the absence of the skilled cinnamon-peeler, it yields a bark
appreciably different from that of Ceylon. Of other cinnamon-producing
districts, those of Southern India may be mentioned as affording the
_Malabar_ or _Tinnevelly_, and the _Tellicherry Cinnamon_ of commerce,
the latter being almost as good as the cinnamon of Ceylon.[1942] The
cultivation in Java commenced in 1825. The plant, according to Miquel,
is a variety of _C. zeylanicum_, distinguished by its very large leaves
which are frequently 8 inches long by 5 inches broad. The island
exported in 1870, 1109 peculs (147,866 lb.); in 1871 only 446 peculs
(59,466 lb.).[1943]

Cinnamon is also grown in the French colony of Guyana and in Brazil,
but on an insignificant scale. The samples of the bark from those
countries which we have examined are quite unlike the cinnamon of
Ceylon. That of Brazil in particular has evidently been taken from
stems several years old.

The importations of cinnamon into the United Kingdom from Ceylon are
shown by the following figures:—

         1867         1869           1870
      859,034 lb.  2,611,473 lb.  2,148,405 lb.

       1871           1872           1876
    1,430,518 lb.  1,015,461 lb.  1,339,060 lb.

During 1872, 56,000 lb. of cinnamon were imported from other countries.

=Description=—Ceylon cinnamon of the finest description is imported
in the form of sticks, about 40 inches in length and ⅜ of an inch
in thickness, formed of tubular pieces of bark about a foot long,
dexterously arranged one within the other, so as to form an even rod of
considerable firmness and solidity. The quills of bark are not rolled
up as simple tubes, but each side curls inwards so as to form a channel
with in-curving sides, a circumstance that gives to the entire stick
a somewhat flattened cylindrical form. The bark composing the stick
is extremely thin, measuring often no more than ¹/₁₁₁₁ of an inch in
thickness. It has a light brown, dull surface, faintly marked with
shining wavy lines, and bearing here and there scars or holes at the
points of insertion of leaves or twigs. The inner surface of the bark
is of a darker hue. The bark is brittle and splintery, with a fragrant
odour, peculiar to itself and the allied barks of the same genus. Its
taste is saccharine, pungent, and aromatic.

[1942] Some of it however is very thick, though neatly quilled.

[1943] _Consular Reports_, Aug. 1873. 952.

The bales of cinnamon which arrive in London are always re-packed
in the dock warehouses, in doing which a certain amount of breakage
occurs. The spice so injured is kept separate and sold as _Small
Cinnamon_, and is very generally used for pharmaceutical purposes. It
is often of excellent quality.

=Microscopic Structure=—By the peeling above described, Ceylon
cinnamon is deprived of the suberous coat and the greater part of the
middle cortical layer, so that it almost consists of the mere liber
(_endophlœum_). Three different layers are to be distinguished on a
transverse section of this tissue:—

1. The external surface which is composed of one to three rows of large
thick-walled cells, forming a coherent ring; it is only interrupted by
bundles of liber-fibres, which are obvious even to the unaided eye;
they compose in fact the wavy lines mentioned in the last page.

2. The middle layer is built up of about ten rows of parenchymatous
thin-walled cells, interrupted by much larger cells containing deposits
of mucilage, while other cells, not larger than those of the parenchyme
itself, are loaded with essential oil.

3. The innermost layer exhibits the same thin-walled but smaller
cells, yet intersected by narrow, somewhat darker, medullary rays, and
likewise interrupted by cells containing either mucilage or essential
oil.

Instead of bundles of liber-fibres, fibres mostly isolated are
scattered through the two inner layers, the parenchyme of which
abounds in small starch granules accompanied by tannic matter. On a
longitudinal section, the length of the liber-fibres becomes more
evident, as well as oil-ducts and gum-ducts.

=Chemical Composition=—The most interesting and noteworthy constituent
of cinnamon is the essential oil, which the bark yields to the extent
of ½ to 1 per cent., and which is distilled in Ceylon,—very seldom in
England. It was prepared by Valerius Cordus, who stated,[1944] somewhat
before 1544, that the oils of _cinnamon_ and _cloves_ belong to the
small number of essential oils which are heavier than water, “fundum
petunt.” About 1571 the essential oils of _cinnamon_, mace, _cloves_,
_pepper_, nutmegs and several others, were also distilled by Guintherus
of Andernach,[1945] and again, about the year 1589, by Porta.[1946]

In the latter part of the last century, it used to be brought to Europe
by the Dutch. During the five years from 1775 to 1779 inclusive, the
average quantity _annually_ disposed of at the sales of the Dutch
East India Company was 176 ounces. The wholesale price in London
between 1776 and 1782 was 21_s._ per ounce; but from 1785 to 1789, the
oil fetched 63_s._ to 68_s._, the increase in value being doubtless
occasioned by the war with Holland commenced in 1782. The oil is now
largely produced in Ceylon, from which island the quantity exported in
1871 was 14,796 ounces; and in 1872, 39,100 ounces.[1947] The oil is
shipped chiefly to England.

Oil of cinnamon is a golden yellow liquid, having a sp. gr. of 1·035,
a powerful cinnamon odour, and a sweet and aromatic but burning taste.
It deviates a ray of polarized light a very little to the left. The oil
consists chiefly of _Cinnamic Aldehyde_, C₆H₅(CH)₂COH, together with a
variable proportion of hydrocarbons. At a low temperature it becomes
turbid by the deposit of a camphor, which we have not examined. The oil
easily absorbs oxygen, becoming thereby contaminated with resin and
cinnamic acid, C₆H₅(CH)₂COOH.

[1944] In his book “De artificiosis extractionibus,” published by
Gesner, Argentorati, 1561, fol. 226.

[1945] _De medicina veteri et nova_, Basileæ, 1571. 630-635.

[1946] _Magiæ Naturalis libri xx._ Neapoli 1589. 184.

[1947] _Ceylon Blue Books_ for 1871 and 1872.

Cinnamon contains sugar, mannite, starch, mucilage, and tannic acid.
The _Cinnamomin_ of Martin (1868) has been shown by Wittstein to be
very probably mere mannite. The effect of iodine on a decoction of
cinnamon will be noticed under the head of Cassia Lignea. Cinnamon
afforded to Schätzler (1862) 5 per cent. of ash consisting chiefly of
the carbonates of calcium and potassium.

=Uses=—Cinnamon is used in medicine as a cordial and stimulant, but is
much more largely consumed as a spice.

=Adulteration=—Cassia lignea being much cheaper than cinnamon, is very
commonly substituted for it. So long as the bark is entire, there is no
difficulty in its recognition, but if it should have been reduced to
powder, the case is widely different. We have found the following tests
of some service, when the spice to be examined is in powder:—Make a
decoction of powdered cinnamon of known genuineness; and one of similar
strength of the suspected powder. When cool and strained, test a fluid
ounce of each with one or two drops of tincture of iodine. A decoction
of cinnamon is but little affected, but in that of cassia a deep
blue-black tint is immediately produced (see further on, Cort. Cassiæ).
The cheap kinds of cassia, known as _Cassia vera_, may be distinguished
from the more valuable _Chinese Cassia_, as well as from cinnamon, by
their richness in mucilage. This can be extracted by cold water as a
thick glairy liquid, giving dense ropy precipitates with corrosive
sublimate or neutral acetate of lead, but not with alcohol.

Other products of the Cinnamon Tree.

_Essential Oil of Cinnamon Leaf_ (_Oleum Cinnamomi foliorum_)—This is a
brown, viscid, essential oil, of clove-like odour, which is sometimes
exported from Ceylon. It has been examined by Stenhouse (1854), who
found it to have a sp. gr. of 1·053, and to consist of a mixture of
_Eugenol_ (p. 284) with a neutral hydrocarbon having the formula
C₁₀H₁₆. It also contains a small quantity of benzoic acid.

_Essential Oil of Cinnamon Root_ (_Oleum Cinnamomi radicis_)—A yellow
liquid, lighter than water, having a mixed odour of camphor and
cinnamon, and a strong camphoraceous taste. Both this oil and that of
the leaf were described by Kämpfer (1712) and by Seba in 1731,[1948]
and perhaps by Garcia de Orta so early as 1563. Solid camphor may
also be obtained from the root. A water distilled from the flowers,
and a fatty oil expressed from the fruits are likewise noticed by old
writers, but are unknown to us.

[1948] _Phil. Trans._ xxxvi. (1731) 107.


CORTEX CASSIÆ LIGNEÆ.

_Cassia Lignea_, _Cassia Bark_.

=Botanical Origin=—Various species of _Cinnamomum_ occurring in the
warm countries of Asia from India eastward, afford what is termed in
commerce _Cassia Bark_. The trees are extremely variable in foliage,
inflorescences and aromatic properties, and the distinctness of several
of the species laid down even in recent works is still uncertain.

The bark which bears _par excellence_ the name of _Cassia_ or _Cassia
lignea_, and which is distinguished on the Continent as _Chinese
Cinnamon_, is a production of the provinces of Kwangtung, Kwangsi and
Kweichau in Southern China. The French expedition of Lieut. Garnier
for the exploration of the Mekong and of Cochin China (1866-68) found
cassia growing in about N. lat. 19° in the forests of the valley of
the Se Ngum, one of the affluents on the left bank of the Mekong near
the frontiers of Annam. A part of this cassia is carried by land into
China, while another part is conveyed to Bangkok.[1949] Although it is
customary to refer it without hesitation to a tree named _Cinnamomum
Cassia_, we find no warrant for such reference: no competent observer
has visited and described the cassia-yielding districts of China
proper, and brought therefrom the specimens requisite for ascertaining
the botanical origin of the bark.[1950]

Cassia lignea is also produced in the Khasya mountains in Eastern
Bengal, whence it is brought down to Calcutta for shipment.[1951] In
this region there are three species of _Cinnamomum_, growing at 1000
to 4000 feet above the sea-level, and all have bark with the flavour
of cinnamon, more or less pure: they are _C. obtusifolium_ Nees, _C.
pauciflorum_ Nees, and _C. Tamala_ Fr. Nees et Eberm.

_Cinnamomum iners_ Reinw., a very variable species occurring in
Continental India, Ceylon, Tavoy, Java, Sumatra and other islands
of the Indian Archipelago, and possibly in the opinion of Thwaites
a mere variety of _C. zeylanicum_, but according to Meissner well
distinguished by its paler, thinner leaves, its nervation, and the
character of its aroma, would appear to yield the cassia bark or wild
cinnamon of Southern India.[1952]

_C. Tamala_ Fr. Nees et Eberm., which besides growing in Khasya is
found in the contiguous regions of Silhet, Sikkim, Nepal, and Kumaon,
and even reaches Australia, probably affords some cassia bark in
Northern India.

Large quantities of a thick sort of cassia have at times been imported
from Singapore and Batavia, much of which is produced in Sumatra.
In the absence of any very reliable information as to its botanical
sources, we may suggest as probable mother plants, _C. Cassia_ Bl. and
_C. Burmanni_ Bl., var. α. _chinense_, both stated by Teijsmann and
Binnendijk to be cultivated in Java.[1953] The latter species, growing
also in the Philippines, most probably affords the cassia bark which is
shipped from Manila.

[1949] Thorel, _Notes médicales du Voyage d’Exploration du Mékong et
de Cochinchine_, Paris, 1870. 30.—Garnier, _Voyage en Indo-Chine_, ii.
(Paris, 1873) 438.

[1950] The greatest market in China for cassia and cinnamon according
to Dr. F. Porter Smith, is Taiwu in Ping-nan hien (Sin-chau fu), in
Kwangsi province.—_Mat. Med. and Nat. Hist. of China_, 1871. 52.—The
capital of Kwangsi is Kweilin fu, literally _Cassia-Forest_.

[1951] Hooker, _Himalayan Journals_, ed. 2. ii. (1855) 303.

[1952] A specimen of the stem-bark of _C. iners_ from Travancore,
presented to us by Dr. Waring, has a delightful odour, but is quite
devoid of the taste of cinnamon.

[1953] _Catalogues Plantarum quæ in Horto Botanico Bogoriensi
coluntur_, Batavia, 1866. 92.

=History=—In the preceding article we have indicated (p. 520) the
remote period at which cassia bark appears to have been known to
the Chinese; and have stated the reasons that led us to believe the
cinnamon of the ancients was that substance. It must, however, be
observed that Theophrastus, Dioscorides, Pliny, Strabo and others,
as well as the remarkable inscription on the temple of Apollo at
Miletus, represent cinnamon and cassia as distinct, but nearly allied
substances. While, on the other hand, the author of the Periplus of the
Erythrean Sea, in enumerating the products shipped from the various
commercial ports of Eastern Africa[1954] in the first century, mentions
_Cassia_ (κμσία or κασσία) of various kinds, but never employs the word
_Cinnamon_ (κινναμώμον).

In the list of productions of India on which duty was levied at the
Roman custom-house at Alexandria, _circa_ A.D. 176-180, _Cinnamomum_
is mentioned as well as _Cassia turiana_, _Xylocassia_ and
_Xylocinnamomum_.[1955] Of the distinction here drawn between cinnamon
and cassia we can give no explanation; but it is worthy of note that
_twigs_ and _branches_ of a _Cinnamomum_ are sold in the Chinese drug
shops, and may not improbably be the _xylocassia_ or _xylocinnamon_ of
the ancients.[1956] The name _Cassia lignea_ would seem to have been
originally bestowed on some such substance, rather than as at present
on a mere bark. The spice was also undoubtedly called _Cassia syrinx_
and _Cassia fistularis_ (p. 221),—names which evidently refer to a
bark which had the form of a tube. In fact there may well have been a
diversity of qualities, some perhaps very costly. It is remarkable that
such is still the case in China, and that the wealthy Chinese employ a
thick variety of cassia, the price of which is as much as 18 dollars
per catty, or about 56_s._ per lb.[1957]

Whether the _Aromata Cassiæ_, which were presented to the Church at
Rome under St. Silvester, A.D. 314-335, was the modern cassia bark, is
rather doubtful. The largest donation, 200 lb., which was accompanied
by pepper, saffron, storax, cloves, and balsam, would appear to have
arrived from Egypt.[1958] Cassia seems to have been known in Western
Europe as early as the 7th century, for it is mentioned with cinnamon
by St. Isidore, archbishop of Seville.[1959] Cassia is named in one of
the Leech-books in use in England prior to the Norman conquest.[1960]
The spice was then sold in London as _Canel_ in 1264, at 10_d._ per
lb., sugar being at the same time 12_d._, cumin 2_d._, and ginger
18_d._[1961] In the _Boke of Nurture_,[1962] written in the 15th
century by John Russell, chamberlain to Humphry, duke of Gloucester,
cassia is spoken of as resembling cinnamon, but cheaper and commoner,
exactly as at the present day.

[1954] Vincent, _Commerce and Navigation of the Ancients in the
Indian Ocean_, ii. (1807) 130. 134. 149. 150. 157.—That the ancients
should confound the different kinds of cassia is really no matter
for surprise, when we moderns, whether botanists, pharmacologists,
or spice-dealers, are unable to point out characters by which to
distinguish the barks of this group, or even to give definite names to
those found in our warehouses.

[1955] Vincent, _op. cit._ ii. 701-716.

[1956] See further on, Allied Products, _Cassia twigs_, page 533.

[1957] Very fine specimens of this costly bark have been kindly
supplied to us by Dr. H. F. Hance, British Vice-Consul at Whampoa.

[1958] Vignolius, _Liber Pontificalis_, Romæ, i. (1724) 94. 95.

[1959] Migne, _Patrologiæ Cursus_, lxxxii. (1850) 622.—St. Isidore
evidently quotes Galen, but his remarks imply that both spices were
known at the period when he wrote.

[1960] Cockayne, _Leechdoms, etc., of Early England_, ii. (1865) 143.

[1961] Rogers, _Hist. of Agriculture and Prices in England_, ii. (1866)
543.

[1962] The book has been reprinted for the Early English Text Society,
1868.—Russell says:—“Looke that your stikkes of _synamome_ be thyn,
bretille and fayre in colewr ... for _canelle_ is not so good in this
crafte and cure.”—And in his directions “_how to make Ypocras_,” he
prescribes _synamome_ in that “_for lordes_,” but “_canelle_” in that
for “_commyn peple_.”

=Production=—We have no information whether the tree which affords
the cassia bark of Southern China is cultivated, or whether it is
exclusively found wild.

The Calcutta cassia bark collected in the Khasya mountains and brought
to Calcutta is afforded by wild trees of small size. Dr. Hooker who
visited the district with Dr. Thomson in 1850, observes that the trade
in the bark is of recent introduction.[1963] The bark which varies much
in thickness, has been scraped of its outer layer.

Cassia is extensively produced in Sumatra, as may be inferred from
the fact that Padang in that island, exported of the bark in 1871,
6127 peculs (817,066 lb.), a large proportion of which was shipped to
America.[1964] Regarding the collection of cassia on the Malabar coast,
in Java and in the Philippines, no particular account has, so far as
we know, been published. Spain imported from the Philippines by way of
Cadiz in 1871, 93,000 lb. of cassia.[1965]

=Description=—_Chinese Cassia lignea_, otherwise called _Chinese
Cinnamon_, which of all the varieties is that most esteemed, and
approaching most nearly to Ceylon cinnamon, arrives in small bundles
about a foot in length and a pound in weight, the pieces of bark being
held together with bands of bamboo.

The bark has a general resemblance to cinnamon, but is in simple
quills, not inserted one within the other. The quills moreover are less
straight, even and regular, and are of a darker brown; and though some
of the bark is extremely thin, other pieces are much stouter than fine
cinnamon,—in fact, it is much less uniform. The outer coat has been
removed with less care than that of Ceylon cinnamon, and pieces can
easily be found with the corky layer untouched by the knife.

Cassia bark breaks with a short fracture. The thicker bark cut
transversely shows a faint white line in the centre running parallel
with the surface. Good cassia in taste resembles cinnamon, than which
it is not less sweet and aromatic, though it is often described as less
fine and delicate in flavour.

An unusual kind of cassia lignea is imported since 1870 from China and
offered in the London market as _China Cinnamon_,[1966] though it is
not the bark that bears this name in continental trade. The new drug
is in _unscraped_ quills, which are mostly of about the thickness of
ordinary Chinese cassia lignea; it has a very saccharine taste and
pungent cinnamon flavour.

[1963] Hooker, _op. cit._

[1964] _Consular Reports_, August 1873. 953.

[1965] Consul Reade, _Report on the Trade, etc., of Cadiz for 1871_,
where the spice is called “_cinnamon_.”

[1966] Flückiger in Wiggers and Husemann’s _Jahresbericht_ for 1872. 52.

The less esteemed kinds of cassia bark, which of late years have
been poured into the market in vast quantity, are known in commerce
as _Cassia lignea_, _Cassia vera_ or _Wild Cassia_, and are further
distinguished by the names of the localities whence shipped, as
Calcutta, Java, Timor, etc.

The barks thus met with vary exceedingly in colour, thickness and
aroma, so that it is vain to attempt any general classification.
Some have a pale cinnamon hue, but most are of a deep rich brown.
They present all variations in thickness, from that of cardboard to
more than a quarter of an inch thick. The flavour is more or less
that of cinnamon, often with some unpleasant addition suggestive
of insects of the genus _Cimex_. Many, besides being aromatic, are
highly mucilaginous, the mucilage being freely imparted to cold water.
Finally, we have met with some thick cassia bark of good appearance
that was distinguished by astringency and the almost entire absence of
aroma.

=Microscopic Structure=—A transverse section of such pieces of
_Chinese Cassia lignea_ as still bear the suberous envelope, exhibits
the following characters. The external surface is made up of several
rows of the usual cork-cells, loaded with brown colouring matter.
In pieces from which the cork-cells have been entirely scraped, the
surface is formed of the mesophlœum, yet by far the largest part of
the bark belongs to the liber or endophlœum. Isolated liber-fibres and
thick-walled cells (stone-cells) are scattered even through the outer
layers of a transverse section. In the middle zone they are numerous,
but do not form a coherent sclerenchymatous ring as in cinnamon (p.
526). The innermost part of the liber shares the structural character
of cinnamon with differences due to age, as for instance the greater
development of the medullary rays. Oil-cells and gum-ducts are likewise
distributed in the parenchyme of the former.

The “_China Cinnamon_” of 1870 (p. 530) comes still nearer to Ceylon
cinnamon, except that it is coated. A transverse section of a quill,
not thicker than one millimetre, exhibits the three layers described
as characterizing that bark. The sclerenchymatous ring is covered by a
parenchyme rich in oil-ducts, so that it is obvious that the flavour
of this drug could not be improved by scraping. The corky layer is
composed of the usual tabular cells. The liber of this drug in fact
agrees with that of Ceylon cinnamon.

In _Cassia Barks of considerable thickness_, the same arrangement of
tissues is met with, but their strong development causes a certain
dissimilarity. Thus the thick-walled cells are more and more separated
one from another, so as to form only small groups. The same applies
also to the liber-fibres, which in thick barks are surrounded by a
parenchyme, loaded with considerable crystals of oxalate of calcium.
The gum-ducts are not larger, but are more numerous in these barks,
which swell considerably in cold water.

=Chemical Composition=—Cassia bark owes its aromatic properties to an
essential oil, which, in a chemical point of view, agrees with that of
Ceylon cinnamon. The flavour of cassia oil is somewhat less agreeable,
and as it exists in the less valuable sorts of cassia, decidedly
different in aroma from that of cinnamon. We find the sp. gr. of a
Chinese cassia oil to be 1·066, and its rotatory power in a column
50 mm. long, only 0°·1 to the right, differing consequently in this
respect from that of cinnamon oil (p. 526).

Oil of cassia sometimes deposits a stearoptene, which when purified is
a colourless, inodorous substance, crystallizing in shining brittle
prisms.[1967] We have never met with it.

[1967] Rochleder and Schwarz (1850) in Gmelin’s _Chemistry_, xvii. 395.

If thin sections of cassia bark are moistened with a dilate solution
of perchloride of iron, the contents of the parenchymatous part of
the whole tissue assume a dingy brown colour; in the outer layers the
starch granules even are coloured. _Tannic matter_ is consequently one
of the chief constituents of the bark; the very cell-walls are also
imbued with it. A decoction of the bark is turned blackish-green by a
persalt of iron.

If cassia bark (or Ceylon cinnamon) is exhausted by _cold water_,
the clear liquid becomes turbid on addition of iodine; the same
occurs if a concentrated solution of iodide of potassium is added.
An abundant precipitate is produced by addition of iodine dissolved
in the potassium salt. The colour of iodine then disappears. There
is consequently a substance present which unites with iodine; and in
fact, if to a _decoction_ of cassia or cinnamon the said solution of
iodine is added, it strikes a bright blue coloration, due to starch.
But the colour quickly disappears, and becomes permanent only after
much of the test has been added. We have not ascertained the nature of
the substance that thus modifies the action of iodine: it can hardly
be tannic matter, as we have found the reaction to be the same when we
used bark that had been previously repeatedly treated with spirit of
wine and then several times with boiling ether.

The mucilage contained in the gum-cells of the thinner quills of cassia
is easily dissolved by cold water, and may be precipitated together
with tannin by neutral acetate of lead, but not by alcohol. In the
thicker barks it appears less soluble, merely swelling into a slimy
jelly.

=Commerce=—Cassia lignea is exported from Canton in enormous and
increasing quantities. The shipments which in 1864 amounted to 13,800
peculs, reached 40,600 in 1869,[1968] 61,220 in 1871, and 76,464 peculs
(10,195,200 lb.) value £267,703, in 1872.[1969] In 1874 the exports
were 54,268 peculs (1 pecul = 133⅓ lb.) and 58,313 peculs in 1878; from
the other ports of China cassia is not shipped to any extent. England
usually receives no more than about 1,000,000 lb. of cassia, of which
only 40,000 lb. appear to be consumed in the country. Hamburg imports
about 2,000,000 lb. annually immediately from China. Yet in 1878 the
quantity imported into London was 26,744 peculs (3,500,000 lb.), that
received at Hamburg 13,548 peculs.

Cassia lignea is exported in chests containing 2 peculs each.

_Oil of cassia_ was shipped from the south of China to the United
Kingdom, to the extent in 1869 of 47,517 lb.; in 1870, of 28,389
lb.[1970] Hamburg is also a very important place for this oil; in the
official statistics of that port for 1875 the imports from China are
stated to have amounted to 30,000 lb., besides 10,000 lb. imported from
Great Britain; in 1876 Hamburg imported 5,900 lb. from China and 17,000
lb. from England.

=Uses=—The same as those of cinnamon.

[1968] _Canton Trade Report_ for 1869.

[1969] _Commercial Reports from H. M. Consuls in China_, presented to
Parliament 1873,—(Consul Robertson).

[1970] _Annual Statement of the Trade and Navigation of the United
Kingdom for 1870._ 290.—66,650 were exported in 1877 from Pakhoi.

Allied Products.

_Cassia Twigs_—The branches of the cassia trees, alluded to at page
529, would appear to be collected from the same trees which yield
the cassia lignea. Garnier (_l.c._ at p. 528) says that the youngest
branches are made into fagots, adding that they have the odour of bugs.

Cassia twigs are not as yet exported to Europe, but they constitute a
very important article of the trade of the interior of China. In 1872
no less than 456,533 lb. of this _Wood of Cassia_ or _Cassia Twigs_
were shipped from Canton, for the most part to other Chinese ports.—The
imports of Hankow, in 1874, of these twigs were 1925 peculs (259,667
lb.) valued at 5677 taels (1 tael about equal to 5_s._ 11_d._).[1971]

In the Paris Exhibition of 1878 we had the opportunity of examining
some bundles of cassia twigs from western Kwangtung. The branches were
as much as 2 feet in length and of the thickness of a finger. We found
their bark to possess the usual flavour of cassia lignea.

_Cassia Buds, Flores Cassiæ_—These are the _immature fruits_ of the
tree yielding Chinese cassia lignea, and have been used in Europe since
the middle ages. In the journal of expenses (A.D. 1359-60) of John,
king of France, when a prisoner at Somerton Castle in England, there
are several entries for the spice under the name of _Flor de Canelle_;
it was very expensive, costing from 8_s._ to 13_s._ per lb., or more
than double the price of mace or cloves. On one occasion two pounds
of it had to be obtained for the king’s use from Bruges.[1972] From
the _Form of Cury_[1973] written in 1390, it appears that cassia buds
(“_Flō de queynel_”) were used in preparing the spiced wine called
_Hippocras_.

Cassia buds are shipped from Canton, but the exports have much
declined. Rondot, writing in 1848,[1974] estimated them as averaging
400 peculs (53,333 lb.) a year. In 1866 there were shipped from Canton
only 233 peculs (31,066 lb.); in 1867, 165 peculs (22,000 lb.)[1975]
The quantity of cassia buds imported into the United Kingdom in 1870
was 29,321 lb.;[1976] the spice is sold chiefly by grocers. The great
market for this drug is Hamburg, where in 1876, according to the
official statistics, 1324 cwt. of cassia buds were imported.

In Southern India, the more mature fruits of one of the varieties of
_Cinnamomum iners_ Reinw. are collected for use, but are very inferior
to the Chinese cassia buds.

_Folia Malabathri_ or _Folia Indi_—is the name given to the dried,
aromatic leaves of certain Indian species of _Cinnamomum_, formerly
employed[1977] in European medicine, but now obsolete. Under the name
_Taj-pat_, the leaves are still used in India; they are collected in
Mysore from wild trees.

_Ishpingo_—This is the designation in Quito of the calyx of a tree of
the laurel tribe, used in Ecuador and Peru in the place of cinnamon.
Though but little known in Europe, it has a remarkable history.

[1971] _Returns of Trade at the Treaty Ports in China for 1872_, p. 34;
for 1874, p. 7.

[1972] Doüet d’Arcq, _Comptes de l’Argenterie des Rois de France_,
1851. 206. 218. 222. 239. etc.

[1973] See p. 245, note 8.

[1974] _Commerce d’exportation de la Chine_, 45.

[1975] _Reports on Trade at the Treaty Ports in China for 1867_,
Shanghai, 1868. 49.

[1976] _Annual Statement of the Trade and Navigation of the U.K. for
1870._ 101.

[1977] For further information consult Heyd, _Levantehandel_, ii.
(1879) 663.

The existence of a spice-yielding region in South America, having come
to the ears of the Spanish conquerors, was regarded as a matter of
interest. It would appear that cinnamon was enumerated in the earliest
accounts among the precious products of the New World.[1978] Such high
importance was attached to it that in Ecuador an expedition was fitted
out. The direction of the enterprise was confided to Gonzalo Pizarro,
who with 340 soldiers, and more than 4000 Indians, laden with supplies,
quitted the city of Quito on Christmas Day, 1539. The expedition,
which lasted two years, resulted in the most lamentable failure, only
130 Spaniards surviving the hardships of the journey. In the account
of it given by Garcilasso de la Vega, the cinnamon tree is described
as having large leaves like those of a laurel, with fruits resembling
acorns growing in clusters.[1979] Fernandez de Oviedo[1980] has also
given some particulars regarding the spice, together with a figure
fairly representing its remarkable form; and the subject has been
noticed by several other Spanish writers, including Monardes.[1981]

Notwithstanding the celebrity thus conferred on the spice, and the fact
that the latter gives its name to a large tract of country,[1982] and
is still the object of a considerable traffic, the tree itself is all
but unknown to science. Meissner places it doubtfully under the genus
Nectandra, with the specific name _cinnamomoides_, but confesses that
its flowers and fruits are alike unknown.[1983]

The spice, for an ample specimen of which we have to thank Dr.
Destruge, of Guayaquil, consists of the enlarged and matured woody
calyx, 1½ to 2 inches in diameter, having the shape of a shallow
funnel, the open part of which is a smooth cup (like the cup of an
acorn), surrounded by a broad, irregular margin, usually recurved. The
outer surface is rough and veiny, and the whole calyx is dark brown,
and has a strong, sweet, aromatic taste, like cinnamon, for which in
Ecuador it is the common substitute.

Dr. Destruge has also furnished us with a specimen of the _bark_, which
is in very small uncoated quills, exactly simulating true cinnamon. We
are not aware whether the bark is thus prepared in quantity.

[1978] Account of Petrus Martyr d’Angleria to Cardinal Ascanio Sforza,
in Michael Herr’s _Die neue Welt_, etc., Strassburg, 1534. fol. 175.

[1979] _Travels of Pedro de Cieza de Leon_, A.D. 1532-50, translated
by Markham (Hakluyt Society) Lond. 1864. chap. 39-40; also _Expedition
of Gonzalo Pizarro to the Land of Cinnamon_, by Garcilasso Inca de la
Vega, forming part of the same volume.

[1980] _Historia de las Indias_, Madrid, i. (1851) 357. (lib. ix. c.
31).

[1981] _De la Canela de nuestras Indias._—_Historia de las cosas que se
traen de nuestras Indias occidentales_, Sevilla, 1574. 98.

[1982] The village of San José de Canelos, which may be considered as
the centre of the cinnamon region, was determined by Mr. Spruce to
be in lat. 1° 20 S., long. 77° 45 W., and at an altitude above the
sea of 1590 feet. The forest of canelos, he tells us, has no definite
boundaries; but the term is popularly assigned to all the upper region
of the Pastasa and its tributaries, from a height of 4000 to 7000
feet on the slopes of the Andes, down to the Amazonian plain, and the
confluence of the Bombonasa and Pastasa.

[1983] De Candolle, _Prodromus_, xv. sect. i. 167.


CORTEX BIBIRU.

_Cortex Nectandræ_; _Greenheart Bark_, _Bibiru_ or _Bebeeru Bark_.

=Botanical Origin=—_Nectandra Rodiæi_ Schomburgk—The Bibiru or
Greenheart is a large forest tree,[1984] growing on rocky soils
in British Guiana, twenty to fifty miles inland. It is found in
abundance on the hill sides which skirt the rivers Essequibo, Cuyuni,
Demerara, Pomeroon and Berbice. The tree attains a height of 80 to 90
feet, with an undivided erect trunk, furnishing an excellent timber
which is ranked in England as one of the eight first-class woods for
shipbuilding, and is to be had in beams of from 60 to 70 feet long.

=History=—In 1769 Bancroft, in his _History of Guiana_, called
attention to the excellent timber afforded by the _Greenheart_ or
_Sipeira_. About the year 1835 it became known that Hugh Rodie, a navy
surgeon who had settled in Demerara some twenty years previously, had
discovered an alkaloid of considerable efficacy as a febrifuge, in the
bark of this tree.[1985] In 1843 this alkaloid, to which Rodie had
given the name _Bebeerine_, was examined by Dr. Douglas Maclagan; and
the following year the tree was described by Schomburgk under the name
of _Nectandra Rodiæi_.[1986]

=Description=—Greenheart bark occurs in long heavy flat pieces, not
unfrequently 4 inches broad and ³/₁₀ of an inch thick, externally of a
light greyish brown, with the inner surface of a more uniform cinnamon
hue and with strong longitudinal striæ. It is hard and brittle; the
fracture coarse-grained, slightly foliaceous, and only fibrous in the
inner layer. The grey suberous coat is always thin, often forming small
warts, and leaving when removed longitudinal depressions analogous
to the _digital furrows_ of Flat Calisaya Bark (p. 353), but mostly
longer. Greenheart bark has a strong bitter taste, but is not aromatic.
Its watery infusion is of a very pale cinnamon brown.

=Microscopic Structure=—The general features of this bark are very
uniform, almost the whole tissue having been changed into thick-walled
cells. Even the cells of the corky layer show secondary deposits; the
primary envelope has entirely disappeared, and no transition from the
suberous coat to liber is obvious.

The prevalent forms of the tissue are the stone-cells and very
short liber-fibres, intersected by small medullary rays and crossed
transversely by parenchyme or small prosenchyme cells with walls a
little less thickened, so as to appear in a transverse section as
irregular squares or groups. The only cells of a peculiar character
are the sharp-pointed fibres of the inner liber, which are curiously
saw-shaped, being provided with numerous protuberances and sinuosities.

[1984] Fig. in Bentley and Trimen’s _Medic. Plants_, part 26 (1877).

[1985] Halliday, _On the Bebeeru tree of British Guiana, and Sulphate
of Bebeerine, the former a substitute for Cinchona, the latter for
Sulphate of Quinine_.—_Edinburgh Med. and Surg. Journ._ vol. xl. 1835.

[1986] _Hooker’s Journ. of Bot._ 1844. 624.

The very small lumen of the thick-walled cells contains a dark brown
mass which is coloured greenish-black by sulphate of iron; the same
coloration takes place throughout the less dense tissue surrounding
the groups of stone-cells, and may in each case be due to tannic
matter.

=Chemical Composition=—Greenheart bark contains an alkaloid which
has long been regarded as peculiar, under the name of _Bibirine_ or
_Bebirine_. It was however shown by Walz in 1860 to be apparently
identical with _Buxine_, a substance discovered as early as 1830 in the
bark and leaves of the Common Box, _Buxus sempervirens_ L. In 1869 the
observation of Walz was to some extent confirmed by one of us,[1987]
who further demonstrated that _Pelosine_, an alkaloid occurring in
the stems and roots of _Cissampelos Pareira_ L. and _Chondodendron
tomentosum_ Ruiz et Pavon (p. 28), is undistinguishable from the
alkaloids of greenheart and box.

The alkaloid of bibiru bark, which may be conveniently prepared from
the crude sulphate used in medicine under the name of _Sulphate of
Bibirine_, is a colourless amorphous substance, the composition of
which is indicated by the formula C₁₈H₂₁NO₃. It is soluble in 5 parts
of absolute alcohol, in 13 of ether, and in 1400 (1800, Walz) of
boiling water, the solution in each case having a decidedly alkaline
reaction on litmus. It dissolves readily in bisulphide of carbon, as
well as in dilute acids. The salts hitherto known are uncrystallizable.
The solution of a neutral acetate affords an abundant white precipitate
on the addition of an alkaline phosphate, nitrate or iodide, of
iodohydrargyrate or platino-cyanide of potassium, perchloride of
mercury, or of nitric or iodic acid.

Maclagan, one of the earliest investigators of greenheart, has
obtained in co-operation with Gamgee[1988] certain alkaloids from the
_wood_ of the tree, to one of which these chemists have assigned the
formula C₂₀H₂₃NO₄ and the name _Nectandria_. Two other alkaloids, the
characters of which have not yet been fully investigated, are stated to
have been obtained from the same source.

_Bibiric Acid_, which Maclagan obtained from the _seeds_, is described
as a colourless, crystalline, deliquescent substance, fusing at 150° C.
and volatile at 200° C., then forming needle-shaped groups.

=Commerce=—The supplies of greenheart bark are extremely uncertain, and
the drug is scarcely to be found in the market. It has been imported in
barrels containing 80 to 84 lb. each, or in bags holding ½ to ¾ cwt.

=Uses=—The bark has been recommended as a bitter tonic and febrifuge,
but is hardly ever employed except in the form of what is called
_Sulphate of Bibirine_, which, as we have said, is _crude Sulphate of
Buxine_.[1989] It is a dark amorphous substance which, having while
in a syrupy state been spread out on glazed plates, is obtained in
thin translucent laminæ. We find it to yield scarcely one-third of its
weight of the pure alkaloid.

[1987] Flückiger, _Neues Jahrbuch für Pharmacie_, xxxi. (1869) 257;
_Pharm. Journ._ xi. (1870) 192.

[1988] _Pharm. Journ._ xi. (1870) 19.

[1989] Mr. W. H. Campbell, of Georgetown, Demerara, has assured me that
neither the bark nor its alkaloid is held in esteem in the colony.—D.
H.


RADIX SASSAFRAS.

_Sassafras Root_; F. _Bois de Sassafras_, _Lignum Sassafras_; G.
_Sassafrasholz_.

=Botanical Origin=—_Sassafras officinalis_ Nees (_Laurus Sassafras_
L.), a tree growing in North America, from Canada, southward to Florida
and Missouri. In the north it is only a shrub, or a small tree 20 to 30
feet high, but in the Middle and Southern United States, and especially
in Virginia and Carolina, it attains a height of 40 to 100 feet. The
leaves are of different forms, some being ovate and entire, and others
two- or three-lobed, the former, it is said, appearing earlier than the
latter.

=History=—Monardes relates that the French during their expedition
to Florida (1562-1564) cured their sick with the wood and root of a
tree called _Sassafras_, the use of which they had learnt from the
Indians.[1990] Laudonnière, who was a member of that expedition, and
diligently set forth the wonders of Florida, observes that, among
forest trees, the most remarkable for its timber and especially for its
fragrant bark, is that called by the savages _Pavame_ and by the French
_Sassafras_.[1991]

The drug was known in Germany, at least since 1582, under the
above names or also by that of _Lignum Floridum_ or _Fennel-wood_,
_Xylomarathrum_.[1992]

The sassafras tree had been introduced into England in the time of
Gerarde (_circa_ 1597), who speaks of a specimen growing at Bow. At
that period the wood and bark of the root were used chiefly in the
treatment of ague.

In 1610, a paper of instructions from the Government of England to
that of the new colony of Virginia, mentions among commodities to be
sent home, “_Small sassafras Rootes_” which are “to be drawen in the
winter and dryed and none to be medled with in the somer;—and yet is
worthe £50 and better per tonne.”[1993] The shipments were afterwards
much overdone, for in 1622 complaint is made that other things than
_tobacco_ and _sassafras_[1994] were neglected to be shipped.

Angelus Sala, an Italian chemist living in Germany about the year
1610-1630, in distilling sassafras noticed that the oil was heavier
than water;[1995] it was quoted in 1683 in the tariff of the apothecary
of the elector of Saxony, at Dresden.[1996] John Maud in 1738 obtained
crystals of safrol as long as 4 inches;[1997] in 1844 they were
examined by Saint-Evre.

=Description=—Sassafras is imported in large branching logs, which
often include the lower portion of the stem, 6 to 12 inches in
diameter.[1998]

[1990] _Historia medicinal de las cosas que se traen de nuestras Indias
occidentales_, (Sevilla, 1574) 51.

[1991] De Laet, _Novus Orbis_, 1633. 215.—René de Laudonnière,
_Histoire notable de la Floride_. 1586.

[1992] _Pharm. Journ._ v. (1876) 1023.

[1993] _Colonial Papers_, vol. i. No. 23 (MS. in the Record Office,
London).

[1994] _Colonial Papers_, vol. ii. No. 4.

[1995] _Opera medico-chymica_, Francofurti, 1682, p. 83.

[1996] Flückiger, _Documente_ (quoted at p. 404, note 7) 70.

[1997] _Phil. Trans. R. Soc. of London_, viii. (1809) 243.

[1998] The sassafras logs met with in English trade often include a
considerable portion of trunk-wood, which, as well as the bark that
covers it, is inert, and should be sawn off and rejected before the
wood is rasped.

The roots proper, which diminish in size down to the thickness of a
quill, are covered with a dull, rough, spongy bark. This bark has
an inert, soft corky layer, beneath which is a firmer inner bark of
brighter hue, rich in essential oil. The wood of the root is light and
easily cut, in colour of a dull reddish-brown, and with a fragrant
odour and spicy taste similar to that of the bark but less strong. It
is usually sold in the shops rasped into shavings.

The _bark of the root_ (_Cortex sassafras_) is a separate article of
commerce, but not much used in England. It consists of channelled,
flattish, or curled, irregular fragments seldom exceeding 4 inches
long by 3 inches broad and generally much smaller, and from ¹/₁₆ to
¼ of an inch in thickness. The inert outer layer has been carefully
removed, leaving a scarred, exfoliating surface. The inner surface
is finely striated and exhibits very minute shining crystals. The
bark has a short, corky fracture, and in colour is a bright cinnamon
brown of various shades. It has a strong and agreeable smell, with an
astringent, aromatic, bitterish taste.

=Microscopic Structure=—The wood of the root exhibits, in transverse
section, concentric rings transversed by narrow medullary rays. Each
ring contains a number of large vessels in its inner part, and more
densely packed cells in its outer. The prevailing part of the wood
consists of prosenchyme cells. Globular cells, loaded with yellow
essential oil, are distributed among the woody prosenchyme. The latter
as well as the medullary rays abounds in starch.

The _bark_ is rich in oil-cells and also contains cells filled with
mucilage; it owes its spongy appearance and exfoliation to the
formation of secondary cork bands (_rhytidoma_) within the mesophlœum
and even in the liber. The cortical tissue abounds in red colouring
matter, and further contains starch and, less abundantly, oxalate of
calcium.

=Chemical Composition=—The wood of the root yields 1 to 2 per cent.
of volatile oil,[1999] and the root-bark twice as much. The stem and
leaves of the tree contain but a very small quantity. The oil, which
as found in commerce is all manufactured in America, has the specific
odour of sassafras, and is colourless, yellow, or reddish-brown,
according, as the distillers assert, to the character of the root
employed. As the colour of the oil does not affect its flavour and
market value, no effort is made to keep separate the different
varieties of root.

Oil of Sassafras has a sp. gr. of 1·087 to 1·094, increasing somewhat
by age (Procter). When cooled, it deposits crystals of _Safrol_ or
_Sassafras Camphor_. This body, which we obtained in the form of hard,
four- or six-sided prisms with the odour of sassafras, often attaining
more than 4 inches in length and 1 inch in diameter, belongs to the
monosymmetric system, as shown by Arzruni.[2000] Safrol, C₁₀H₁₀O₂,
liquefies at 8°·5 C. (47° F.), having at 12° C. a sp. gr. of 1·11; it
boils at 232° C., and is devoid of rotatory power, nor is it soluble in
alkalis. The researches of Grimaux and Ruotte (1869) show the oil to
contain nine-tenths of its weight of _Safrol_ which they observed only
in the liquid state.

[1999] According to information obtained by Procter, 11 bushels of
chips (the charge of a still) yields from 1 to 5 lb. of oil, the amount
varying with the quality of the root and the proportion of bark it
may contain.—Procter, _Essay on Sassafras in the Proceedings of the
American Pharm. Association_, 1866. 217.

[2000] Poggendorff’s _Annalen_, clviii. (1876) 249, with figures of the
crystals.

Another constituent of sassafras oil has been termed by Grimaux and
Ruotte _Safrene_; it boils at 155° to 157° C., has a sp. gr. of 0·834
and the formula C₁₀H₁₆. It has the same odour as safrol, but deviates
the plane of polarization to the right.

It was further found by the same observers that the crude oil contains
an extremely small quantity of a substance of the phenol class, which
can be removed by caustic lye and separated by an acid.

We succeeded in obtaining this substance by using that portion of the
crude oil from which the safrol had separated. The phenol remains in
the mother-liquor after it has again been cooled and has afforded a new
crystallization of safrol. The phenol thus obtained assumes a beautiful
greenish blue hue on addition of an alcoholic solution of perchloride
of iron.

The _Sassarubin_ and _Sassafrin_ of Hare (1837) are impure products of
the decomposition of sassafras oil by means of sulphuric acid.

The _bark_ and also to some extent the _wood_, in both cases of the
root, contain tannic acid which produces a blue colour with persalts
of iron. By oxidation, we must suppose, it is converted into the red
colouring matter deposited in the bark and, in smaller quantity, in
the heartwood of old trees. The young wood is nearly white. The said
red substance probably agrees with that to which Reinsch in 1845 and
1846 gave the name of _Sassafrid_, and is doubtless analogous to
cinchona-red and ratanhia-red. Reinsch obtained it to the extent of 9·2
per cent.

=Production and Commerce=—Baltimore is the chief mart for sassafras
root, bark and oil, which are brought thither from within a circuit
of 300 miles. The roots are extracted from the ground by the help of
levers, partly barked and partly sent untouched to the market, or are
cut up into chips for distillation on the spot. Of the bark as much as
100,000 lb. were received in Baltimore in 1866. The quantity of oil
annually produced previous to the war is estimated at 15,000 to 20,000
lb. There are isolated small distillers in Pennsylvania and West New
Jersey, who are allowed by the owners of a “_sassafras wilderness_” to
remove from the ground the roots and stumps without charge. Sassafras
root is not medicinal in the United States, the more aromatic root-bark
being reasonably preferred.[2001]

=Uses=—Sassafras is reputed to be sudorific and stimulant, but in
British practice it is only given in combination with sarsaparilla and
guaiacum. Shavings of the wood are sold to make _Sassafras Tea_.

In America the essential oil is used to give a pleasant flavour to
effervescing drinks, tobacco and toilet soaps.[2002]

=Substitutes=—The odour of sassafras is common to several plants of the
order _Lauraceæ_. Thus the bark of _Mesphilodaphne Sassafras_ Meissn.,
a tree of Brazil, resembles in odour true sassafras. We have seen a
very thick sassafras bark brought from India, the same we suppose as
that which Mason[2003] describes as abundantly produced in Burma.

The bark of _Atherosperma moschatum_ Labillardière, an Australian tree,
is occasionally exported from Australia under the name of Sassafras
bark. It has the odour of the true drug, but differs from it by its
grey colour.

[2001] Besides this, _the pith of sassafras_ is also there used as a
popular remedy; it is entirely devoid of odour and taste, and is very
slightly mucilaginous.

[2002] _American Journ. of Pharm._ 1871. 470.

[2003] _Burmah, its people and natural productions_, 1860. 497.

The large separate cotyledons of two lauraceous trees of the Rio Negro,
doubtfully referred by Meissner to the genus _Nectandra_, furnish the
so-called _Sassafras Nuts_ or _Puchury_ or _Pilchurim Beans_ of Brazil,
occasionally to be met with in old drug warehouses.

On the Orinoko and in Guiana an oleo-resin, called _Sassafras Oil_
or _Laurel Oil_, is obtained by boring into the stem of _Oreodaphne
opifera_ Nees, which sometimes contains a cavity holding a large
quantity of this fluid.[2004] A similar oil (_Aceite de Sassafras_) is
afforded on the Rio Negro by _Nectandra Cymbarum_ Nees.[2005]

[2004] _Brit. Guiana_ at the Paris Exhibition, 1878, Sect. C. p. 7.

[2005] Spruce in _Hooker’s Journ. of Bot._ vii. (1855) 278.




THYMELEÆ.


CORTEX MEZEREI.

_Mezereon Bark_; F. _Ecorce de Mézéréon_, _Bois gentil_; G.
_Seidelbast-Rinde_.

=Botanical Origin=—_Daphne Mezereum_ L., an erect shrub, 1 to 3 feet
high, the branches of which are crowded with purple flowers in the
early spring, before the full expansion of the oblong, lanceolate,
deciduous leaves. The flowers are succeeded by red berries. It is a
native of the hilly parts of almost the whole of Europe, from Italy
to the Arctic regions, and extends eastward to Siberia. In Britain it
occurs here and there in a few of the southern and midland counties,
and even reaches Yorkshire and Westmoreland, but there is reason to
think it is not truly indigenous. Gerarde, who was well acquainted with
it, did not regard it as a British plant.

=History=—The Arabian physicians used a plant called _Mázariyún_,
the effects of which they compared to those of euphorbium; it was
probably a species of _Daphne_. The word _mázariyún_ is, we are told by
competent Arabic scholars, not of Arabic origin, but in all probability
derived from the Greek idiom, in which however we are unable to trace
its origin. _D. Mezereum_ was known to the early botanists of Europe,
as _Daphnoides Chamælæa_, _Thymelæa_, _Chamædaphne_. Tragus described
it and figured it in 1546 under the name of _Mezereum Germanicum_. The
bark had a place in the German pharmacy of the 17th century under the
name of cortex _Coccognidii_ s. _Mezerei_; the berries were the _Cocca
gnidia_ s. _knidia_ of the old pharmacy.

=Description=—Mezereon has a very tough and fibrous bark easily
removed in long strips which curl inwards as they dry; it is collected
in winter and made up into rolls or bundles. The bark, which rarely
exceeds ¹/₂₀ of an inch in thickness, has an internal greyish or
reddish-brown corky coat which is easily separable from a green inner
layer, white and satiny on the side next the wood. That of younger
branches is marked with prominent leaf-scars. The bark is too tough to
be broken, but easily tears into fibrous strips. When fresh, it has an
unpleasant odour which is lost in drying; its taste is persistently
burning and acrid. Applied in a moist state to the skin, it occasions,
after some hours, redness and even vesication.

=Microscopic Structure=—The cambial zone is formed of about ten rows
of delicate unequal cells. The libre consists chiefly of simple fibres
alternating with parenchymatous bundles, and traversed by medullary
rays. The fibres are very long,—frequently more than 3 mm., and from 5
to 10 mkm. in diameter, their walls being always but little thickened.
In the outer part of the liber there occur bundles of thick-walled
bast-tubes, while chlorophyll and starch granules appear generally
throughout the middle cortical layer. The suberous coat is made up of
about 30 dense rows of thin-walled tabular cells, which examined in
a tangential section, have an hexagonal outline. Small quantities of
tannic matter are deposited in the cambial and suberous zones.

=Chemical Composition=—The acrid principle of mezereon is a resinoid
substance contained in the inner bark; it has not yet been examined.
The fruits were found by Martius (1862) to contain more than 40 per
cent. of a fatty, vesicating oil, which appears to be likewise present
in the bark.

The name _Daphnin_ has been given to a crystallizable substance
obtained by Vauquelin in 1808 from _Daphne alpina_, and afterwards
found by C. G. Gmelin and Baer in the bark of _D. Mezereum_. Zwenger
in 1860 ascertained it to be a glucoside of bitter taste, having
the composition C₁₅H₁₆O₉ + 2 OH₂, the same as that of Æsculin, the
fluorescing principle occurring in the bark of _Æsculus Hippocastanum_
and the root-bark of _Gelsemium nitidum_ Michaux (_G. sempervirens_
Aiton).—_Coccognin_, isolated in 1870 by Casselmann from the fruits of
_D. Mezereum_, appears to be closely allied to if not identical with
daphnin.

When daphnin is boiled with dilute hydrochloric or sulphuric acid,
it furnishes _Daphnetin_, C₉H₆O₄ + OH₂, described by Zwenger as
crystallizing in colourless prisms. By dry distillation of an alcoholic
extract of mezereon bark, the same chemist obtained _Umbelliferone_ (p.
322).

=Uses=—Mezereon taken internally is supposed to be alterative and
sudorific, and useful in venereal, rheumatic and scrofulous complaints;
but in English medicine it is never now given except as an ingredient
of the Compound Decoction of Sarsaparilla. An ethereal extract of
the bark has been introduced (1867) as an ingredient of a powerful
stimulating liniment. On the Continent, the bark itself, soaked in
vinegar and water, is applied with a bandage as a vesicant.

=Substitutes=—Owing to the difficulty of procuring the bark of the
root of _D. Mezereum_, the herbalists who supply the London druggists
have been long in the habit of substituting that of _D. Laureola_ L.,
an evergreen species, not uncommon in woods and hedge-sides in several
parts of England. The _British Pharmacopœia_ (1864 and 1867) permits
_Cortex Mezerei_ to be obtained indiscriminately from either of these
species, and does not follow the London College in insisting on the
_bark of the root_ alone. That of the stem of _D. Laureola_ corresponds
in structure with the bark of the true mezereon, but wants the
prominent leaf-scars that mark the upper branches of the latter; it is
reputed to be somewhat less acrid than mezereon bark. The mezereon bark
of English trade is now mostly imported from Germany, and seems to be
derived from _D. Mezereum_.

In France, use is made of the stem-bark of _D. Gnidium_ L., a
shrub growing throughout the whole Mediterranean region as far as
Morocco. The bark is dark grey or brown, marked with numerous whitish
leaf-scars, which display a very regular spiral arrangement. The leaves
themselves, some of which are occasionally met with in the drug, are
sharply mucronate and very narrow. As to structural peculiarities,
the bark of _D. Gnidium_ has the medullary rays more obvious and more
loaded with tannic matters than those of _D. Mezereum_; but the middle
cortical layer is less developed. The bark, which is called _Ecorce de
Gaoru_, is employed as an epispastic.




ARTOCARPACEÆ.


CARICÆ.

_Fructus Caricæ_, _Fici_; _Figs_; F. _Figues_; G. _Feigen_.

=Botanical Origin=—_Ficus Carica_ L., a deciduous tree, 15 to 20 feet
in height, with large rough leaves, forming a handsome mass of foliage.

The native country of the fig stretches from the steppes of the Eastern
Aral, along the south and south-west coast of the Caspian Sea (Ghilan,
Mazanderan, and the Caucasus), through Kurdistan, to Asia Minor and
Syria. In these countries the fig-tree ascends into the mountain
region, growing undoubtedly wild in the Taurus at an elevation of 4,800
feet.[2006]

The fig-tree is repeatedly mentioned in the Scriptures, where with the
vine it often stands as the symbol of peace and plenty. The fig was
not known in Greece, the Archipelago, and the neighbouring coasts of
Asia Minor during the Homeric age, though both were very common in the
time of Plato. The fig-tree was early introduced into Italy, whence it
reached Spain and Gaul. In the opinion of palæontologists the fig-tree
was originally indigenous to the last named Mediterranean regions.

Charlemagne, A.D. 812, ordered its cultivation in Central Europe.
It was brought to England in the reign of Henry VIII. by Cardinal
Pole, whose trees still exist in the garden of Lambeth Palace. But
it had certainly been in cultivation at a much earlier period, for
the historian Matthew Paris relates[2007] that the year 1257 was so
inclement that apples and pears were scarce in England, and that
_figs_, cherries, and plums totally failed to ripen.

At the present day the fig-tree is found cultivated in most of the
temperate countries both of the Old and New World.[2008] It is met with
in the plains of north-western India, and in the outer hills of the
north-western Himalaya as high as 5,000 feet; also in the Dekkan, and
in Beluchistan and Afghanistan.

[2006] Ritter, _Erdkunde von Asien_, vii. (1844) 2. 544.

[2007] _Eng. Hist._, Bohn’s ed., iii. (1854) 255.

[2008] Introduced into Mexico by Cortez about A.D. 1560.

=History=—Figs were a valued article of food among the ancient
Hebrews[2009] and Greeks, as they are to the present day in the warmer
countries bordering the Mediterranean.[2010] In the time of Pliny many
varieties were in cultivation. The Latin word _Carica_ was first used
to designate the dried fig of Caria, a strip of country in Asia Minor
opposite Rhodes, an esteemed variety of the fruit corresponding to the
Smyrna fig of modern times.

In a diploma granted by Chilperic II., king of the Franks, to the
monastery of Corbie, A.D. 716, mention is made of “_Karigas_” in
connection with dates, almonds and olives, by which we think dried figs
(_Caricæ_) were intended.[2011] Dried figs were a regular article of
trade during the middle ages, from the southern to the northern parts
of Europe. In 1380 the citizens of Bruges, in regulating the duties
which the “Lombards,” _i.e._ Italians, had to pay for their imports,
quoted also figs from Cyprus and from Marbella, a place south-west of
Malaga.[2012]

In England the average price between A.D. 1264 and 1398 was about
1¾_d._ per lb., raisins and currants being 2¾_d._[2013]

=Description=—A fig consists of a thick, fleshy, hollow receptacle
of a pear-shaped form, on the inner face of which grow a multitude
of minute fruits.[2014] This receptacle, which is provided with an
orifice at the top, is at first green, tough and leathery, exuding when
pricked a milky juice. The orifice is surrounded, and almost closed by
a number of thick, fleshy scales, near which and within the fig, the
male flowers are situated, but they are often wanting or are not fully
developed. The female flowers stand further within the receptacle, in
the body of which they are closely packed; they are stalked, have a
5-leafed perianth and a bipartite stigma. The ovary, which is generally
one-celled, becomes when ripe a minute, dry, hard nut, popularly
regarded as a seed.

[2009] See in particular 1 Sam. xxv. 18 and 1 Chron. xii. 40; where
we read of large supplies of dried figs being provided for the use of
fighting men. Also Num. xx. 5; Jer. xxiv. 2; 2 Reg. xx. 7.

[2010] On the Riviera of Genoa dried figs eaten with bread are a common
winter food of the peasantry.

[2011] Pardessus, _Diplomata_, _Chartæ_, etc., ii. (1849) 309.

[2012] _Recesse und andere Akten der Hansetage_, ii. (Leipzig, 1872)
235.

[2013] Rogers, _Hist. of Agriculture and Prices in England_, i. (1866)
632.

[2014] Albertus Magnus, in allusion to the peculiar growth of the fig,
remarks that the tree “fructum autem profert sine flore.” Page 386 of
the work quoted in the Appendix.

As the fig advances to maturity, the receptacle enlarges, becomes
softer and more juicy, a saccharine fluid replacing the acrid milky
sap. It also acquires a reddish hue, while its exterior becomes purple,
brown, or yellow, though in some varieties it continues green. The
fresh fig has an agreeable and extremely saccharine taste, but it wants
the juiciness and refreshing acidity that characterize many other
fruits.

If fig is not gathered its stalk loses its firmness, the fruit hangs
pendulous from the branch, begins to shrivel and become more and
more saccharine by loss of water, and ultimately, if the climate is
favourable, it assumes the condition of a _dried fig_. On the large
scale however, figs are not dried on the tree, but are gathered and
exposed to the sun and air in light trays till they acquire the proper
degree of dryness. They can only be preserved in those regions where
the summer and autumn are very warm and dry.

Dried figs are termed by the dealers either _natural_ or _pulled_. The
first are those which have not been compressed in the packing, and
still retain their original shape.[2015] The second are those which
after drying have been made supple by squeezing and kneading, and in
that state packed with pressure into drums and boxes.

Smyrna figs, which are the most esteemed sort, are of the latter kind.
They are of irregular, flattened form, tough, translucent, covered
with a saccharine efflorescence; they have a pleasant fruity smell and
luscious taste. Figs of inferior quality, as those called in the market
_Greek Figs_, differ chiefly in being smaller and less pulpy.

=Microscopic Structure=—The outer layer of a dried fig is made up of
small, thick-walled and densely packed cells, so as to form a kind
of skin. The inner lax parenchyme consists of larger thin-walled
cells, traversed by vascular bundles and large, slightly branched,
laticiferous vessels. The latter contain a granular substance not
soluble in water. In the parenchyme, stellate crystals of oxalate of
calcium occur, but in no considerable number.

=Chemical Composition=—The chemical changes which take place in the fig
during maturation are important, but no researches have yet been made
for their elucidation. The chief chemical substance in the ripe fig is
grape sugar, which constitutes from 60 to 70 per cent. of the dried
fruit. Gum and fatty matter appear to be present only in very small
quantity. We have observed that unripe figs are rich in starch.

=Production and Commerce=—Dried figs were imported into the United
Kingdom in 1872 to the amount of 141,847 cwt., of which 91,721 cwt.
were shipped from Asiatic Turkey, the remainder being from Portugal,
Spain, the Austrian territories and other countries. In 1876 the
imports were 163,763 cwt., valued at £318,717.

Kalamata, in the Gulf of Messenia, Greece, and Cosenza in the Italian
province of Calabria citeriore, are also particularly known as
supplying figs to some parts of continental Europe. In 1876 the exports
of Kalamata to Trieste were 9½ millions of kilogrammes.

=Uses=—Dried figs are thought to be slightly laxative, and as such are
occasionally recommended in habitual constipation. They enter into the
composition of _Confectio Sennæ_.

[2015] The word _Eleme_ applied in the London shops to dried figs of
superior quality (“Eleme Figs”) is probably a corruption of the Turkish
_ellémé_, signifying _hand-picked_.




MORACEÆ.


FRUCTUS MORI.

_Baccæ Mori_, _Mora_; _Mulberries_; F. _Mûres_; G. _Maulbeeren_.

=Botanical Origin=—_Morus nigra_ L., a handsome bushy tree, about 30
feet in height, growing wild in Northern Asia Minor, Armenia, and the
southern Caucasian regions as far as Persia. In Italy, it was employed
for feeding the silkworm until about the year 1434, when _M. alba_ L.
was introduced from the Levant,[2016] and has ever since been commonly
preferred. Yet in Greece, in many of the Greek islands, Calabria and
Corsica, the species planted for the silkworm is still _M. nigra_.

The mulberry tree is now cultivated throughout Europe, yet, excepting
in the regions named, by no means abundantly. It ripens its fruit in
England, as well as in Southern Sweden and Gottland, and in Christiania
(Schübeler).

=History=—The mulberry tree is mentioned in the Old Testament,[2017]
and by most of the early Greek and Roman writers. Among the large
number of useful plants ordered by Charlemagne (A.D. 812) to be
cultivated on the imperial farms, the mulberry tree (_Morarius_) did
not escape notice.[2018] We meet with it also in a plan sketched A.D.
820, for the gardens of the monastery of St. Gall in Switzerland.[2019]
The cultivation of the mulberry in Spain is implied by a reference
to the preparation of _Syrup of Mulberries_ in the Calendar of
Cordova,[2020] which dates from the year 961.

A curious reference to mulberries, proving them to have been far more
esteemed in ancient times than at present, occurs in the statutes
of the abbey of Corbie of Normandy, in which we find a _Brevis de
Melle_, showing how much _honey_ the tenants of the monastic lands were
required to pay annually, followed by a statement of the quantity of
_Mulberries_ which each farm was expected to supply.[2021]

=Description=—The tree bears unisexual catkins; the female, of an ovoid
form, consists of numerous flowers with green four-lobed perianths and
two linear stigmas. The lobes of the perianth overlapping each other
become fleshy, and by their lateral aggregation form the spurious
berry, which is shortly stalked, oblong, an inch in length, and, when
ripe, of an intense purple. By detaching a single fruit, the lobes of
the former perianth may be still discerned. Each fruit encloses a hard
lenticular nucule, covering a pendulous seed with curved embryo and
fleshy albumen.

Mulberries are extremely juicy and have a refreshing, subacid,
saccharine taste; but they are devoid of the fine aroma that
distinguishes many fruits of the order _Rosaceæ_.

=Chemical Composition=—In an analysis made by H. van Hees (1857) 100
parts of mulberries yielded the following constituents:—

    Glucose and uncrystallizable sugar                       9·19
    Free acid (supposed to be _malic_)                       1·86
    Albuminous matter                                        0·39
    Pectic matter, fat, salts, and gum                       2·03
    Ash                                                      0·57
    Insoluble matters (the seeds, pectose, cellulose, &c.)   1·25
    Water                                                   84·71

[2016] A. De Candolle, _Géogr. botanique_, ii. (1855) 856.

[2017] 2 Sam. v. 23, 24.

[2018] Pertz, _Monumenta Germaniæ historica_, Leges, iii. (1835)
181.—Consult also Hehn, _Kulturpflanzen_, 1877.

[2019] F. Keller, _Bauriss des Klosters S. Gallen_, facsimile, Zürich,
1844.

[2020] _Le Calendrier de Cordoue de l’année_ 961, publié par R. Dozy,
Leyde, 1873. 67.

[2021] Guérard, _Polyptique de l’Abbé Irminon_, Paris, ii. 335.

With regard to the results of researches on other edible fruits, made
about the same time in the laboratory of Fresenius, it would appear
that the mulberry is one of the most saccharine, being only surpassed
by the cherry (10·79 of sugar) and grape (10·6 to 19·0).[2022] It is
richer in sugar than the following, namely:—

    Raspberries, yielding 4  per cent. of sugar and 1·48 of (malic) acid.
    Strawberries      ”   5·7     ”        ”        1·31      ”       ”
    Whortleberries    ”   5·8     ”        ”        1·34      ”       ”
    Currants          ”   6·1     ”        ”        2·04      ”       ”

The amount of free acid in the mulberry is not small, nor is it
excessive. The small proportion of insoluble matters is worthy of
notice in comparison, for instance with the whortleberry, which
contains no less than 13 per cent. The colouring matter of the mulberry
has not been examined. The acid is probably not simply malic, but in
part tartaric.

=Uses=—The sole use in medicine of mulberries is for the preparation
of a syrup employed to flavour or colour any other medicines. In
Greece, the fruit is submitted to fermentation, thereby furnishing an
inebriating beverage.




CANNABINEÆ.


HERBA CANNABIS.

_Cannabis Indica_; _Indian Hemp_; F. _Chanvre Indien_; G. _Hanfkraut_.

=Botanical Origin=—_Cannabis sativa_ L., Common Hemp, an annual
diœcious plant, native of Western and Central Asia, cultivated in
temperate as well as in tropical countries.

It grows wild luxuriantly on the banks of the lower Ural and Volga
near the Caspian Sea, extending thence to Persia, the Altai range, and
Northern and Western China. It is found in Kashmir and on the Himalaya,
growing 10 to 12 feet high, and thriving vigorously at an elevation
of 6000 to 10,000 feet. It likewise occurs in Tropical Africa, on the
eastern and western coasts as well as in the central tracts watered
by the Congo and Zambesi, but whether truly indigenous is doubtful.
It has been naturalized in Brazil, north of Rio de Janeiro, the seeds
having been brought thither by the negroes from Western Africa. The
cultivation of hemp is carried on in many parts of continental Europe,
but especially in Central and Southern Russia.

The hemp plant grown in India exhibits certain differences as
contrasted with that cultivated in Europe, which were noticed by
Rumphius in the 17th century, and which (about A.D. 1790), induced
Lamarck to claim for the former plant the rank of a distinct species,
under the name of _Cannabis indica_. But the variations observed in the
two plants are of so little botanical importance and are so inconstant,
that the maintenance of _C. indica_ as distinct from _C. sativa_ has
been abandoned by general consent.

[2022] The fig excepted, which is much more saccharine than any.

In a medicinal point of view, there is a wide dissimilarity between
hemp grown in India and that produced in Europe, the former being
vastly more potent. Yet even in India there is much variation, for,
according to Jameson, the plant grown at altitudes of 6000 to 8000 feet
affords the resin known as _Charas_, which cannot be obtained from that
cultivated on the plains.[2023]

=History=—Hemp has been propagated on account of its textile fibre and
oily seeds from a remote period.

The ancient Chinese herbal called _Rh-ya_, written about the 5th
century B.C., notices the fact that the hemp plant is of two kinds, the
one producing seeds, the other flowers only.[2024] In Susruta, Charaka
and other early works on Hindu medicine, hemp (_B’hanga_) is mentioned
as a remedy. Herodotus states that hemp grows in Scythia both wild and
cultivated, and that the Thracians made garments from it which can
hardly be distinguished from linen. He also describes how the Scythians
expose themselves as in a bath to the vapour of the seeds thrown on hot
coals.[2025]

The Greeks and Romans appear to have been unacquainted with the
medicinal powers of hemp, unless indeed the care-destroying Νηπενθές
should, as Royle has supposed, be referred to this plant. According to
Stanislas Julien,[2026] anæsthetic powers were ascribed by the Chinese
to preparations of hemp as early as the commencement of the 3rd century.

The employment of hemp both medical and dietetic appears to have spread
slowly through India and Persia to the Arabians, amongst whom the
plant was used in the early middle ages. The famous heretical sect of
Mahomedans, whose murderous deeds struck terror into the hearts of the
Crusaders during the 11th and 12th centuries, derived their name of
_Hashishin_, or, as it is commonly written, _assassins_, from _hashísh_
the Arabic for _hemp_,[2027] which in certain of their rites they used
as an intoxicant.[2028] In 1286 of our era, the Sultan of Egypt, Bibars
al Bondokdary, prohibited the sale of hashish, the monopoly of which
had been leased before.[2029]

The use of hemp (_bhang_) in India was particularly noticed by Garcia
de Orta[2030] (1563), and the plant was subsequently figured by Rheede,
who described the drug as largely used on the Malabar coast. It would
seem about this time to have been imported into Europe, at least
occasionally, for Berlu in his _Treasury of Drugs_, 1690, describes
it as coming from Bantam in the East Indies, and “_of an infatuating
quality and pernicious use_.“

[2023] _Journ. of the Agric. and Hortic. Soc. of India_, viii. 167.

[2024] Bretschneider, _On Chinese Botanical Works_, 1870. 5. 10. Part
of the _Rh-ya_ was written in the 12th cent. B.C.

[2025] Rawlinson’s translation, iii. (1859) book 4, chap. 74-5.

[2026] _Comptes Rendus_, xxviii. (1849) 195.

[2027] Hence the words _assassin_ and _assassinate_. Weil, however,
is of opinion that the word _assassin_ is more probably derived from
_sikkin_, a dagger.—_Geschichte der Chalifen_, iv. (1860) 101.

[2028] The miscreant who assassinated Justice Norman at Calcutta, 20
Sept. 1871, is said to have acted under the influence of _hashísh_.
Bellew (_Indus to the Tigris_, 1874. 218) states that the Afghan chief
who murdered Dr. Forbes in 1842, had for some days previously been more
or less intoxicated with _Charas_ or _Bhang_.

[2029] _Quatremère_, _Memoires sur l’Egypte_ ii. (1811) 504, according
to Makrisi.

[2030] _Colloquios dos simples e drogas e cousas medicinaes da India_,
ed. 2, Lisboa, 1872, 27.

It was Napoleon’s expedition to Egypt that was the means of again
calling attention to the peculiar properties of hemp, by the accounts
of De Sacy (1809) and Rouger (1810). But the introduction of the
Indian drug into European medicine is of still more recent date, and
is chiefly due to the experiments made in Calcutta by O’Shaughnessy
in 1838-39.[2031] Although the astonishing effects produced in India
by the administration of preparations of hemp are seldom witnessed in
the cooler climate of Britain, the powers of the drug are sufficiently
manifest to give it an established place in the pharmacopœia.

=Production=—Though hemp is grown in many parts of India, yet as a drug
it is chiefly produced in a limited area in the districts of Bogra and
Rājshāhi, north of Calcutta, where the plant is cultivated for the
purpose in a systematic manner. The retail sale, like that of opium and
spirits, is restricted by a license, which in 1871-2 produced to the
Government of Bengal about £120,000, while upon opium (chiefly consumed
in Assam) the amount raised was £310,000.[2032] Bhang is one of the
principal commodities imported into India from Turkestan.

=Description=—The leaves of hemp have long stalks with small stipules
at their bases, and are composed of 5 to 7 lanceolate-acuminate
leaflets, sharply serrate at the margin. The loose panicles of male
flowers, and the short spikes of female flowers, are produced on
separate plants, from the axils of the leaves. The fruits, called
_Hemp-seeds_, are small grey nuts or achenes, each containing a single
oily seed. In common with other plants of the order, hemp abounds in
silica which gives a roughness to its leaves and stems. In European
medicine, the only hemp employed is that grown in India, which occurs
in two principal forms, namely:—

1. _=Bhang=_, _Siddhī_ or _Sabzī_ (Hindustani); _Hashish_ or _Qinnaq_
(Arabic). This consists of the dried leaves and small stalks, which are
of a dark green colour, coarsely broken, and mixed with here and there
a few fruits. It has a peculiar but not unpleasant odour, and scarcely
any taste. In India, it is smoked either with or without tobacco, but
more commonly it is made up with flour and various additions into a
sweetmeat or _majun_,[2033] of a green colour. Another form of taking
it is that of an infusion, made by immersing the pounded leaves in cold
water.

2. _=Ganja=_ (Hindustani); _Qinnab_ (Arabic); _Guaza_[2034] of the
London drug-brokers. These are the flowering or fruiting shoots of
the female plant, and consist in some samples of straight, stiff,
woody stems some inches long, surrounded by the upward branching
flower-stalks; in others of more succulent and much shorter shoots, 2
to 3 inches long, and of less regular form. In either case, the shoots
have a compressed and glutinous appearance, are very brittle, and of
a brownish-green hue. In odour and in the absence of taste _ganja_
resembles _bhang_. It is said that after the leaves which constitute
_bhang_ have been gathered, little shoots sprout from the stem, and
that these picked off and dried form what is called _ganja_.[2035]

[2031] For a notice of them, see O’Shaughnessy, _On the preparation of
the Indian Hemp or Gunjah_, Calcutta, 1839; also _Bengal Dispensatory_,
Calcutta, 1842. 579-604. An immense number of references to writers who
have touched on the medicinal properties of hemp, will be found in the
elaborate essay entitled _Studien über den Hanf_, by Dr. G. Martius
(Erlangen, 1855).

[2032] Blue Book quoted at p. 52, note 1.

[2033] Magi-oun is the Persian name for electuaries, of which more
than 70 are found, for instance, in the _Pharmacopœia Persica_ (see
Appendix, Angelus), p. 291 to 321.

[2034] This name is not used in India, but seems to be a corruption of
_ganja_.

[2035] Powell, _Economic Products of the Punjab_, Roorkee, i. (1868)
293.

=Chemical Composition=—The most interesting constituents of hemp, from
a medical point of view, are the _resin_ and _volatile oil_.

The former was first obtained in a state of comparative purity by T.
and H. Smith in 1846.[2036] It is a brown amorphous solid, burning with
a bright white flame and leaving no ash. It has a very potent action
when taken internally, two-thirds of a grain acting as a powerful
narcotic, and one grain producing complete intoxication. From the
experiments of Messrs. Smith, it seems to us impossible to doubt that
to this resin the energetic effects of cannabis are mainly due.

When water is repeatedly distilled from considerable quantities of
hemp, fresh lots of the latter being used for each operation, a
volatile oil lighter than water is obtained, together with ammonia.
This oil, according to the observations of Personne (1857), is
amber-coloured, and has an oppressive hemp-like smell. It sometimes
deposits an abundance of small crystals. With due precautions it may
be separated into two bodies, the one of which, named by Personne
_Cannabene_,[2037] is liquid and colourless, with the formula
C₁₈H₂₀; the other, which is called _Hydride of Cannabene_, is a
solid, separating from alcohol in platy crystals to which Personne
assigns the formula C₁₈H₂₂. He asserts that cannabene has indubitably
a physiological action, and even claims it as the sole active
principle of hemp. Its vapour he states to produce when breathed a
singular sensation of shuddering, a desire of locomotion, followed by
prostration and sometimes by syncope.[2038] Bohlig in 1840 observed
similar effects from the oil, which he obtained from the fresh herb,
just after flowering, to the extent of 0·3 per cent.

It remains to be proved whether an _alkaloid_ is present in hemp, as
suggested by Preobraschensky.[2039]

The other constituents of hemp are those commonly occurring in other
plants. The leaves yield nearly 20 per cent. of ash.

As to the resin of Indian hemp, Bolas and Francis in treating it
with nitric acid, converted it into _Oxycannabin_, C₂₀H₂₀N₂O₇. This
interesting substance may, they say, be obtained in large prisms from a
solution in methylic alcohol. It melts at 176° C. and then evaporates
without decomposition; it is neutral.[2040] One of us (F.) has
endeavoured to obtain it from the purified resin of charas, but without
success.

[2036] _Pharm. Journ._ vi. (1847) 171.

[2037] _Journ. de Pharm._ xxxix. (1857) 48; Canstatt’s _Jahresbericht_
for 1857, i. 28.

[2038] Personne, though he admits the activity of the resin prepared
by Smith’s process, contends that it is a mixed body, and that further
purification deprives it of all volatile matter and renders it inert.
This is not astonishing when one finds that the “purification” was
effected by treatment with caustic lime or soda-lime, and exposure to
a temperature of 300° C. (572° F.)! That the resin of the Edinburgh
chemists does not owe its activity to volatile matter, is proved by
their own experiment of exposing a small quantity in a very thin layer
to 82° C. for 8 hours: the medicinal action of the resin so treated was
found to be unimpaired.

[2039] Dragendorff’s _Jahresbericht_, 1876. 98.

[2040] _Chemical News_, xxiv. (1871) 77.

=Uses=—Hemp is employed as a soporific, anodyne, antispasmodic, and
as a nervous stimulant. It is used in the form of alcoholic extract,
administered either in a solid or liquid form. In the East it is
consumed to an enormous extent by Hindus and Mahomedans, who either
smoke it with tobacco, or swallow it in combination with other
substances.[2041]

Charas.

No account of hemp as a drug would be complete without some notice of
this substance, which is regarded as of great importance by Asiatic
nations.

_Charas_ or _Churrus_ is the resin which exudes in minute drops from
the yellow glands, with which the plant is provided in increasing
number according to the elevated temperature (and altitude?) of the
country where it grows. The varieties of hemp richest in resin, at
least in the Laos country in the Malayan Peninsula, scarcely attain
the height of 3 feet, and show densely curled leaves.[2042] Charas is
collected in several ways:—one is by rubbing the tops of the plants
in the hands when the seeds are ripe, and scraping from the fingers
the adhering resin. Another is thus performed:—men clothed in leather
garments walk about among growing hemp, in doing which the resin of
the plant attaches itself to the leather, whence it is from time to
time scraped off. A third method consists in collecting, with many
precautions to avoid its poisonous effects, the dust which is caused
when heaps of dry _bhang_ are stirred about.[2043]

By whichever of these processes obtained, charas is of necessity a foul
and crude drug, the use of which is properly excluded from civilized
medicine. As before remarked (p. 547) it is not obtainable from hemp
grown indiscriminately in any situation even in India, but is only to
be got from plants produced at a certain elevation on the hills.

The best charas, which is that brought from Yarkand, is a brown,
earthy-looking substance, forming compact yet friable, irregular
masses of considerable size. Examined under a strong pocket lens, it
appears to be made up of minute, transparent grains of brown resin,
agglutinated with short hairs of the plant. It has a hemp-like odour,
with but little taste even in alcoholic solution. A second and a third
quality of Yarkand charas represent the substance in a less pure state.
Charas viewed under the microscope exhibits a crystalline structure,
due to inorganic matter. It yields from ¼ to ⅓ of its weight of an
amorphous resin, which is readily dissolved by bisulphide of carbon or
spirit of wine. The resin does not redden litmus, nor is it soluble in
caustic potash. It has a dark brown colour, which we have not succeeded
in removing by animal charcoal. The residual part of charas yields to
water a little chloride of sodium, and consists in large proportion
of carbonate of calcium and peroxide of iron. These results have been
obtained in examining samples from Yarkand.[2044] Other specimens which
we have also examined, have the aspect of a compact dark resin.

Charas is exported from Yarkand[2045] and Kashgar, the first of which
places exported during 1867, 1830 _maunds_ (146,400 lb.) to Lê, whence
the commodity is carried to the Punjab and Kashmir. Smaller quantities
are annually imported from Kandahar and Samarkand;[2046] some charas
appears also (1876) to be exported from Mandshuria to China. The drug
is mostly consumed by smoking with tobacco; it is not found in European
commerce.

[2041] For further information, consult Cooke’s _Seven Sisters of
Sleep_, Lond., chap. xv.-xvii; also _Jahresbericht_ of Wiggers and
Husemann, 1872. 600.

[2042] Garnier, _Voyage d’Exploration en Indo-Chine_, ii. (1873) 410.

[2043] Powell, _Economic Products of the Punjab_, Roorkee, 1868. 293.

[2044] Obtained by Colonel H. Strachey, and now in the Kew Museum. It
is by no means evident by what process they were collected.

[2045] Forsyth, _Correspondence on Mission to Yarkand_, ordered by the
House of Commons to be printed, Feb. 28, 1871; also Henderson and Hume,
_Lahore to Yarkand_, Lond. 1873. 334.

[2046] Stewart, _Punjab Plants_, Lahore, 1869. 216.


STROBILI HUMULI.

_Humulus vel Lupulus_; _Hops_; F. _Houblon_; G. _Hopfen_.

=Botanical Origin=—_Humulus Lupulus_ L.,—a diœcious perennial plant,
producing long annual twining stems which climb freely over trees
and bushes. It is found wild, especially in thickets on the banks
of rivers, throughout all Europe, from Spain, Sicily and Greece to
Scandinavia; and extends also to the Caucasus, the South Caspian
region, and through Central and Southern Siberia to the Altai
mountains. It has been introduced into North America, Brazil (Rio
Grande do Sul), and Australia.

=History=—Hops have been used from a remote period in the brewing of
beer, of which they are now regarded as an indispensable ingredient.
Hop gardens, under the name _humularia_ or _humuleta_, are mentioned
as existing in France and Germany in the 8th and 9th centuries; and
Bohemian and Bavarian hops have been known as an esteemed kind since
the 11th century. A grant alleged to have been made by William the
Conqueror in 1069, of hops and hop-lands in the county of Salop,[2047]
would indicate, were it free from doubt, a very early cultivation of
the hop in England.

As to the use made of hops in these early times, it would appear that
they were regarded in somewhat of a medicinal aspect. In the _Herbarium
of Apuleius_,[2048] an English manuscript written about A.D. 1050, it
is said of the hop (_hymele_) that its good qualities are such that men
put it in their usual drinks; and St. Hildegard,[2049] a century later,
states that the hop (_hoppho_) is added to beverages, partly for its
wholesome bitterness, and partly because it makes them keep.

Hops for brewing were among the produce which the tenants of the abbey
of St. Germain in Paris[2050] had to furnish to the monastery in the
beginning of the 9th century; yet in the middle of the 14th century,
beer without such addition was still brewed in Paris.

[2047] Blount, _Tenures of Land and Customs of Manors_, edited by
Hazlitt, 1874. 165.

[2048] _Leechdoms, Wortcunning and Starcraft of Early England_, edited
by Cockayne, i. (1864) 173; ii. (1865) ix.

[2049] _Opera Omnia_, accurante J. P. Migne, Paris, 1855. 1153.

[2050] Guérard, _Polyptique de l’abbé Irminon_, i. (1844) 714. 896.

The brewsters, bakers and millers of London were the subject of a
mandate of Edward I. in A.D. 1298; but there is no reason for inferring
that the manufacture of malt liquor at this period involved the use of
hops. It is plain indeed that somewhat later, hops were _not_ generally
used, for in the 4th year of Henry VI. (1425-26), an information was
laid against a person for putting into beer “an unwholesome weed called
_an hopp_;”[2051] and in the same reign, Parliament was petitioned
against “that wicked weed called _hops_.”

But it is evident that hops were soon found to possess good qualities,
and that though their use was denounced, it was not suppressed. Thus
in the regulations for the household of Henry VIII. (1530-31), there
is an injunction that the brewer is “not to put any hops or brimstone
into the ale”;[2052] while in the very same year (1530), hundreds of
pounds of Flemish hops were purchased for the use of the noble family
of L’Estranges of Hunstanton.[2053]

In 1552 the cultivation of hops in England was distinctly sanctioned by
the 5th and 6th of Edward VI. c. 5, which directs that land formerly in
tillage should again be so cultivated, excepting it should have been
set with _hops_ or saffron. Notwithstanding these facts, hops were
for a long period hardly regarded an essential in brewing, as may be
gathered from the remark of Gerarde (_ob._ A.D. 1607), who speaks of
them as used “to season” beer or ale, explaining that notwithstanding
their manifold virtues, they “rather make it a physical drinke to
keepe the body in health, than an ordinary drinke for the quenching of
our thirst.” In reality, other herbs were for a long period employed
to impart to malt liquor a bitter or aromatic taste, as Ground Ivy
(_Nepeta Glechoma_ Benth.); anciently called Ale-hoof or Gill; Alecost
(_Balsamita vulgaris_ L.); Sweet Gale (_Myrica Gale_ L.); and Sage
(_Salvia officinalis_ L.). Even Long Pepper and Bay Berries were used
for the same purpose,[2054] but in addition to hops.

Though English hops were esteemed superior to foreign, and were
extensively grown as early as 1603, as shown by an act of James
I.,[2055] Flemish hops continued to be imported in considerable
quantities down to 1693.

[2051] The authority for this statement is an isolated memorandum in
a MS. volume (No. 980) by Thomas Gybbons, preserved in the Harleian
collection in the British Museum.

[2052] _Archæologia_, iii. (1786) 157.

[2053] _Ibid._ xxv. (1834) 505.

[2054] Holinshed, _Chronicles_, vol. i. book 2. cap. 6.

[2055] 1 James I. (anno 1603) cap. 18.

=Structure=—The inflorescence of the male plant constitutes a large
panicle; that of the female is less conspicuous, consisting of stalked
catkins which by their growth develope large leafy imbricating bracts,
ultimately forming an ovoid cone or strobile, which is the officinal
part. This catkin consists of a short central zigzag stalk, bearing
overlapping rudimentary leaflets, each represented by a pair of
stipules. Between them are 4 female florets, each supported by a bract.
After flowering, the stipules as well as the bracts are much enlarged,
and then form the persistent, yellowish-green, pendulous strobile. At
maturity, each bract infolds at its base a small lenticular closed
fruit or nut, ⅒ of an inch in diameter. The nut is surrounded by a
membranous, one-leafed perigone, and contains within its fragile, brown
shell an exalbuminous seed. These fruits, as well as the axis and the
base of all the leaf-like organs, are beset with numerous shining,
translucent glands, to which the aromatic smell and taste of hops are
due.

=Description=—Hops as found in commerce consist entirely of the fully
developed strobiles or cones, more or less compressed. They have a
greenish yellow colour, an agreeable and peculiar aroma, and a bitter
aromatic burning taste. When rubbed in the hand they feel clammy, and
emit a more powerful odour. By keeping, hops lose their greenish colour
and become brown, at the same time acquiring an unpleasant odour, by
reason of the formation of a little valerianic acid. Exposure to the
vapour of sulphurous acid retards or prevents this alteration. For
medicinal use, hops smelling of sulphurous acid should be avoided,
though in reality the acid speedily becomes innocuous. Liebig has
refuted the objections raised by brewers to the sulphuring of hops.

=Chemical Composition=—Besides the constituents of the glands
which are described in the next article, hops contain according to
Etti’s elaborate investigations (1876, 1878) _humulotannic acid_
and _phlobaphene_. The former is a whitish amorphous mass, soluble
in alcohol, hot water or acetic ether, not in ether. By heating the
humulotannic acid at 130° C., or by boiling its aqueous or alcoholic
solutions, it gives off water, and is transformed into phlobaphene, a
dark red amorphous substance,

     (C₂₅H₂₄O₁₃)₂ = OH₂ · C₅₀H₄₆O₂₅.
    humulotannic        phlobaphene.
        acid.

The latter substance, on boiling it with dilute mineral acids, again
loses water and furnishes glucose.

From raw phlobaphene ether removes the _bitter principles_ of hops,
a colourless crystallizable and a brown amorphous resin, besides
chlorophyll and essential oil.

By distilling hops with water, 0·9 per cent. of _essential oil_ are
obtained. Personne (1854) stated it to contain _Valerol_,[2056] C₆H₁₀O,
which passes into valerianic acid; the latter in fact occurs in the
glands, yet according to Méhu[2057] only to the extent of 0·1 to
0·17 per cent. When distilled from the fresh strobiles the oil has a
greenish colour, but a reddish-brown when old hops have been employed.
We find it to be devoid of rotatory power, neutral to litmus paper, and
not striking any remarkable coloration with concentrated sulphuric acid.

Griessmayer (1874) has shown that hops contain _Trimethylamine_, and
in small proportion a liquid volatile alkaloid not yet analysed, which
he terms _Lupuline_. The latter is stated to have the odour of conine,
and to assume a violet hue when treated with chromate of potassium and
sulphuric acid.

Lastly, Etti also found arabic (pectic) acid, phosphates, nitrates,
malates, citrates, and also sulphates, chiefly of potassium, to occur
in hops. The amount of ash afforded by hops dried at 100° C. would
appear to be on an average about 6-7 per cent.

=Production and Commerce=—England was estimated as having in 1873,
63,276 acres under hops. The chief district for the cultivation is the
county of Kent, where in that year 39,040 acres were devoted to this
plant. Hops are grown to a much smaller extent in Sussex, and in still
diminished quantity in Herefordshire, Hampshire, Worcestershire and
Surrey. The other counties of England and the principality of Wales
produce but a trifling amount, and Scotland none at all.

In continental Europe, hops are most largely produced in Bavaria and
Württemberg, Belgium and France, but in each on a smaller scale than in
England. France in 1872 is stated to have 9223 acres under hops.[2058]

[2056] A substance with which we are not acquainted.

[2057] _Thèse_, Montpellier, 1867.

[2058] _Agricultural Returns of Great Britain_, &c., 1873, presented to
Parliament, 48. 49. 70. 71.

Notwithstanding the extensive production of hops in England, there is
a large importation from other countries. The importation in 1872 was
135,965 cwt., valued at £679,276: of this quantity, Belgium supplied
66,630 cwt., Germany 36,612 cwt., Holland 16,675 cwt., the United
States 10,414 cwt., France 5,328 cwt. During the same period hops were
exported from the United Kingdom to the extent of 31,215 cwt.[2059]

=Uses=—Hops are administered medicinally as a tonic and sedative,
chiefly in the form of tincture, infusion or extract.


GLANDULÆ HUMULI.

_Lupulina_; _Lupulin_, _Lupulinic Grains_; F. _Lupuline_; G.
_Hopfendrüsen_, _Hopfenstaub_.

=Botanical Origin=—_Humulus Lupulus_ L. (see preceding article). The
minute, shining, translucent glands of the strobile constitute when
detached therefrom the substance called _Lupulin_.

=History=—The glands of hop were separated and chemically examined by
L. A. Planche, a pharmacien of Paris, whose observations were first
briefly described by Loiseleur-Deslongchamps in 1819.[2060] In the
following year, Dr. A. W. Ives of New York[2061] published an account
of his experiments upon hops and their glands, to which latter he
applied the name of _Lupulin_. Payen and Chevallier, Planche and
others, made further experiments on the same subject, endorsing the
recommendation of Ives that lupulin (or, as they preferred to call it,
_Lupuline_) might be advantageously used in medicine in place of hops.

[2059] _Annual Statement of the Trade of the United Kingdom_ for 1872.
49. 93.

[2060] _Manuel des Plantes usuelles et indigènes_, 1819. ii. 503.

[2061] Silliman’s _Journ. of Science_, ii. (1820) 302.

=Production=—Lupulin is obtained by stripping off the bracts of hops,
and shaking and rubbing them; and then separating the powder by a
sieve. The powder thus detached ought to be washed by decantation,
so as to remove from it the sand or earth with which it is always
contaminated; finally it should be dried, and stored in well-closed
bottles. From the dried strobiles, 8 to 12 per cent. of lupulin may be
obtained.

=Description=—Lupulin seen in quantity appears as a yellowish-brown
granular powder, having an agreeable odour of hops and a bitter
aromatic taste. It is gradually wetted by water, instantly by alcohol
or ether, but not by potash or sulphuric acid. By trituration in a
mortar the cells are ruptured so that it may be worked into a plastic
mass. Thrown into the air and then ignited, it burns with a brilliant
flame like lycopodium.

=Microscopic Structure=—The lupulinic gland or grain, like the
generality of analogous organs, is formed by an intumescence of the
cuticle of the nuculæ and bracts of hop (see p. 552). Each grain
is originally attached by a very short stalk, which is no longer
perceptible in the drug. The gland, exhausted by ether and macerated in
water, is a globular or ovoid thin-walled sac, measuring from 140 to
240 mkm. It consists of two distinct, nearly hemispherical parts; that
originally provided with the stalk is built up of tabular polyhedric
cells, whilst the upper hemisphere shows a continuous delicate
membrane. This part therefore easily collapses, and thus exhibits a
variety of form, the greater also as the grains turn pole or equator to
the observer.[2062]

The hop gland is filled with a thick, dark brown or yellowish liquid,
which in the drug is contracted into one mass occupying the centre of
the gland. It may be expelled in minute drops when the wall is made to
burst by warming the grain in glycerin. The colouring matter, to which
the wall owes its fine yellow colour, adheres more obstinately to the
thinner hemisphere, and is more easily extracted from the thicker part
by means of ether.

=Chemical Composition=—The odour of lupulinic grains resides in the
essential oil, described in the previous article. The bitter principle
formerly called _Lupulin_ or _Lupulite_ was first isolated by Lermer
(1863) who called it the _bitter acid of hops_ (_Hopfenbittersäure_).
It crystallizes in large brittle rhombic prisms, and possesses in a
high degree the peculiar bitter taste of beer, in which however it can
be present only in very small proportion, it being nearly insoluble in
water, though easily dissolved by many other liquids. The composition
of this acid, C₃₂H₅₀O₇, appears to approximate it to absinthiin; it is
contained in the glands in but small proportion. Still smaller is the
amount of another crystallizable constituent, regarded by Lermer as an
alkaloid.

The main contents of the hop gland consist of wax (_Myricylic
palmitate_, according to Lermer), and resins, one of which is
crystalline and unites with bases.

A good specimen of German lupulin, dried over sulphuric acid, yielded
us 7·3 per cent. of ash. The same drug exhausted by boiling ether,
afforded 76·8 per cent. of an extremely aromatic extract, which on
exposure to the steam-bath for a week, lost 3·03 per cent., this loss
corresponding to the volatile oil and acids. The residual part was
soluble in glacial acetic acid and could therefore contain but very
little fatty matter.

=Uses=—The drug has the properties of hops, but with less of
astringency. It is not often prescribed.

=Adulteration=—Lupulin is apt to contain sand, and on incineration
often leaves a large amount of ash. Other extraneous matters which
are not unfrequent may be easily recognized by means of a lens. As
the essential oil in lupulin is soon resinified, the latter should be
preferred fresh, and should be kept excluded from the air.

[2062] For a full account of the formation of the glands, see Trécul,
_Annales des Sciences Nat._, Bot., i. (1854) 299. An abstract may be
found in Méhu’s _Etude du Houblon et du Lupulin_, Montpellier, 1867.




ULMACEÆ.


CORTEX ULMI.

_Elm Bark_; F. _Ecorce d’Orme_; G. _Ulmenrinde_, _Rüsterrinde_.

=Botanical Origin=—_Ulmus campestris_ Smith, the Common Elm, a stately
tree, widely diffused over Central, Southern and Eastern Europe,
southward to Northern Africa and Asia Minor, and eastward as far
as Amurland, Northern China, and Japan. It is probably not truly
indigenous to Great Britain; but the Wych Elm, _U. montana_ With., is
certainly wild in the northern and western counties;[2063] the latter
is, according to Schübeler, the only species indigenous to Norway.

History—The classical writers, and especially Dioscorides, were
familiar with the astringent properties of the bark of πτελέα, by
which name _Ulmus campestris_ is understood. Imaginary virtues are
ascribed by Pliny to the bark and leaves of _Ulmus_. Elm bark is
frequently prescribed in the English Leech-books of the 11th century,
at which period a great many plants of Southern Europe had already been
introduced into Britain.[2064] Its use is also noticed in Turner’s
_Herbal_ (1568) and in Parkinson’s _Theater of Plants_ (1640), the
author of the latter remarking that “all the parts of the Elme are of
much use in Physicke.”

In the Scandinavian antiquity the fibrous bark of _Ulmus montana_ used
to be made up into ropes.[2065]

=Description=—Elm bark for use in medicine should be removed from
the tree in early spring, deprived of its rough corky outer coat,
and then dried. Thus prepared, it is found in the shops in the form
of broad flattish pieces, of a rusty yellowish colour, and striated
surface especially on the inner side. It is tough and fibrous, nearly
inodorous, and has a woody, slightly astringent taste.

=Microscopic Structure=—The liber, which is the only officinal part,
consists of thick-walled, tangentially-extended parenchyme, in which
there are some large cells filled with mucilage, while the rest contain
a red-brown colouring matter. The mucilage forms a stratified deposit
within the cell. Large bast-bundles, arranged in irregular rows,
alternate with the parenchyme, and are intersected by narrow, reddish,
medullary rays consisting of 2 or 3 rows of cells. The bast-bundles
contain numerous long tubes about 30 mkm. thick, with narrow cavities;
and besides these, somewhat larger tubes with porous transverse
walls (cribriform vessels). Each cubic cell of the neighbouring
bast-parenchyme encloses a large crystal, seldom well defined, of
oxalate of calcium.

[2063] On the word _elm_, Dr. Prior remarks that it is nearly
identical in all the Germanic and Scandinavian dialects, yet does
not find its root in any of them, but is an adaptation of the Latin
_Ulmus_.—_Popular Names of British Plants_, ed. 2. 1870. 71.

[2064] _Leechdoms, Wortcunning and Starcraft of Early England_, edited
by Rev. O. Cockayne, ii. (1865) pp. 53. 67. 79. 99. 127 and p. xii.—In
the Anglo-Saxon recipes, both _Elm_ and _Wych Elm_ are named in the
Welsh “_Meddygon Myddfai_” (see Appendix). Elmwydd or Ilwyf and “Ulmus
romanus,” Ilwyf Rhufain, are met with.

[2065] Schübeler, _Pflanzenwelt Norwegens_, 1873-75, p. 216.

=Chemistry=—The chief soluble constituent of elm hark is mucilage with
a small proportion of tannic acid, the latter, according to Johanson
(1875), probably agreeing with that of oak bark and bark of willows.
The concentrated infusion of elm bark yields a brown precipitate with
perchloride of iron; the dilute assumes a green coloration with that
test. Starch is wanting, or only occurs in the middle cortical layer,
which is usually rejected.

Elms in summer-time frequently exude a gum which, by contact with the
air, is converted into a brown insoluble mass, called _Ulmin_. This
name has been extended to various decomposition-products of organic
bodies, the nature and affinities of which are but little known.[2066]

=Uses=—Elm bark is prescribed in decoction as a weak mucilaginous
astringent, but is almost obsolete.


CORTEX ULMI FULVÆ.

_Slippery Elm Bark._

=Botanical Origin=—_Ulmus fulva_ Michaux, the Red or Slippery Elm, a
small or middle-sized tree,[2067] seldom more than 30 to 40 feet high,
growing on the banks of streams in the central and northern United
States from Western New England to Wisconsin and Kentucky, and found
also in Canada.

=History=—The Indians of North America attributed medicinal virtues to
the bark of the Slippery Elm, which they used as a healing application
to wounds, and in decoction as a wash for skin diseases. It is the
“Salve Bark” or “Cortex unguentarius” of Schöpf.[2068] Bigelow, writing
in 1824, remarks that the mucilaginous qualities of the inner bark are
well known.

=Description=—The Slippery Elm Bark used in medicine consists of the
liber only. It forms large flat pieces, often 2 to 3 feet long by
several inches broad, and usually ¹/₂₀ to ²/₂₀ of an inch thick, of
an extremely tough and fibrous texture. It has a light reddish-brown
colour, an odour resembling that of fenugreek (which is common to the
leaves also), and a simply mucilaginous taste.

In collecting the bark the tree is destroyed, and no effort is made
to replace it, the wood being nearly valueless. Thus the supply is
diminishing year by year, and the collectors who formerly obtained
large quantities of the bark in New York and other eastern states have
now to go westward for supplies.[2069]

[2066] Gmelin, _Chemistry_, xvii. (1866) 458.

[2067] Fig. in Bentley and Trimen’s _Med. Plants_, part 34 (1878).

[2068] _Mat. Med. Americ._, Erlangæ, 1787. 32.

[2069] _Proceedings of the American Pharmaceutical Association for
1873_, xxi. 435.

=Microscopic Structure=—The transverse section shows a series of
undulating layers of large yellowish bundles of soft liber-fibres,
alternating with small brown parenchymatous bands. The whole tissue
is traversed by numerous narrow medullary rays, and interrupted by
large intercellular mucilage-ducts. In order to examine the latter,
longitudinal sections ought to be moistened with benzol, aqueous
liquids causing great alteration. In a longitudinal section, the
mucilage-ducts are seen to be 70 to 100 mkm. long, and to contain
colourless masses of mucilage, distinctly showing a series of layers.
Crystals of calcium oxalate, as well as small starch grains, are very
plentiful throughout the surrounding parenchyme.

=Chemical Composition=—The most interesting constituent of the bark is
mucilage, which is imparted to either cold or hot water, but does not
form a true solution. The bark moistened with 20 parts of water swells
considerably, and becomes enveloped by a thick neutral mucilage, which
is not altered either by iodine or perchloride of iron. This mucilage
when diluted, even with a triple volume of water, will yield only a
few drops when thrown on a paper filter. The liquid which drains out
is precipitable by neutral acetate of lead. By addition of absolute
alcohol, the concentrated mucilage is not rendered turbid, but forms a
colourless transparent fluid deposit.

=Adulteration=—Farinaceous substances admixed to the powdered drug may
be detected by means of the microscope.

=Uses=—Slippery Elm Bark is a demulcent like althæa or linseed. The
powder is much used in America for making poultices; it is said to
preserve lard from rancidity, if the latter is melted with it and kept
in contact for a short time.




EUPHORBIACEÆ.


EUPHORBIUM.

_Euphorbium_, _Gum Euphorbium_; F. _Gomme-résine d’Euphorbe_; G.
_Euphorbium_.

=Botanical Origin=—_Euphorbia resinifera_ Berg, a leafless, glaucous,
perennial plant resembling a cactus, and attaining 6 or more feet in
height. Its stems are ascending, fleshy and quadrangular, each side
measuring about an inch. The angles of the stem are furnished at
intervals with pairs of divergent, horizontal, straight spines about ¼
of an inch long, and confluent at the base into ovate, subtriangular
discs. These spines represent stipules: above each pair of them is a
depression, indicating a leaf-bud. The inflorescence is arranged at the
summits of the branches, on stalks each bearing three flowers, the two
outer of which are supported on pedicels. The fruit is tricoccous, ³/₁₀
of an inch wide, with each carpel slightly compressed and keeled.[2070]

The plant is a native of Morocco, growing on the lower slopes of
the Atlas in the southern province of Suse. Dr. Hooker and his
fellow-travellers met with it in 1870 at Netifa and Imsfuia,[2071]
south-east of the city of Morocco, which appears to be its westward
limit.

=History=—Euphorbium was known to the ancients. Dioscorides[2072] and
Pliny[2073] both describe its collection on Mount Atlas in Africa, and
notice its extreme acridity. According to the latter writer, the drug
received its name in honour of Euphorbus, physician to Juba II., king
of Mauritania. This monarch, who after a long reign died about A.D. 18,
was distinguished for his literary attainments, and was the author of
several books[2074] which included treatises on opium and euphorbium.
The latter work was apparently extant in the time of Pliny.

[2070] Fig. in Bentley and Trimen’s _Med. Plants_, part 24 (1877).

[2071] Or Mesfioua, according to Ball, who also quotes the province
Demenet.—_Journ. of the Linnean Soc._ Bot. xvi. (1878) 662.

[2072] Lib. iii. c. 86.

[2073] Lib. v. c. 1; lib. xxv. c. 38.

[2074] Smith, _Dict. of Greek and Roman Biography_, ii. (1846) 636.

Euphorbium is mentioned by numerous other early writers on medicine, as
Rufus Ephesius, who probably flourished during the reign of Trajan, by
Galen in the 2nd century, and by Vindicianus and Oribasius in the 4th.
Aëtius and Paulus Ægineta, who lived respectively in the 6th and 7th
centuries, were likewise acquainted with it; and it was also known to
the Arabian school of medicine. In describing the route from Aghmat to
Fez, El-Bekri[2075] of Granada, in 1068, mentioned the numerous plants
“El-forbioun” growing in the country of the Beni Ouareth, a tribe of
the Sanhadja; the author noticed the spiny herbaceous stems of the
shrub abounding in the purgative milky juice.

Höst[2076] (1760-1768) stated that the plant, which he also correctly
compared with Opuntia, is growing near Agader, south of Mogador.

The plant yielding euphorbium was further described at the beginning
of the present century by an English merchant named Jackson, who had
resided many years in Morocco. From the figures he published,[2077]
the species was doubtfully identified with _Euphorbia canariensis_
L., a large cactus-like shrub, with quadrangular or hexagonal stems,
abounding on scorched and arid rocks in the Canary Islands.

In the year 1749 it was pointed out in the (_Admiralty_) _Manual of
Scientific Enquiry_, that the stems of which fragrants are found in
commercial euphorbium, do not agree with those of _E. canariensis_.
Berg carried the comparison further, and finally from the fragments
in question drew up a botanical description, which with an excellent
figure he published[2078] as _Euphorbia resinifera_. The correctness
of his observations has been fully justified by specimens[2079] which
were transmitted to the Royal Gardens, Kew, in 1870, and now form
flourishing plants.

[2075] _Description de l’Afrique septentrionale_, traduite par M. de
Slane, _Journal asiatique_, xiii. (Paris, 1859) 413.

[2076] _Nachrichten von Marokos und Fes_, Kopenhagen, 1781. 308.

[2077] _Account of the Empire of Morocco and the district of Suse_,
Lond. 1809. 81. pl. 7.—The plate represents an entire plant, and also
what purports to be a portion of a branch of the natural size. The
latter is really the figure of a different species,—apparently that
which has been recently named by Cosson _Euphorbia Beaumierana_.

[2078] Berg und Schmidt, _Offizinelle Gewächse_, iv. (1863) xxxiv. d.

[2079] They were procured by Mr. William Grace, and forwarded to
England by Mr. C. F. Carstensen, British Vice-Consul at Mogador.

The drug has a place in all the early printed pharmacopœias.

=Collection=—Euphorbium is obtained by making incisions in the green
fleshy branches of the plant. These incisions occasion an abundant
exudation of milky juice which hardens by exposure to the air,
encrusting the stems down which it flows; it is finally collected
in the latter part of the summer. So great is the acridity of the
exudation, that the collector is obliged to tie a cloth over his mouth
and nostrils, to prevent the entrance of the irritating dust. The drug
is said to be collected in districts lying east and south-east of the
city of Morocco.

=Description=—The drug consists of irregular pieces, seldom more
than an inch across and mostly smaller, of a dull yellow or brown
waxy-looking substance, among which portions of the angular spiny
stem of the plant may be met with. Many of the pieces encrust a tuft
of spines or a flower-stalk or are hollow. The substance is brittle
and translucent; splinters examined under the microscope exhibit
no particular structure, even by the aid of polarized light; nor
are starch granules visible.[2080] The odour is slightly aromatic,
especially if heat is applied; but 10 lb. of the drug which we
subjected to distillation afforded no essential oil. Euphorbium has
a persistent and extremely acrid taste; its dust excites violent
sneezing, and if inhaled, as when the drug is powdered, occasions
alarming symptoms.

=Chemical Composition=—Analysis of euphorbium performed by one of
us[2081] showed the composition of the drug to be as follows:—

    Amorphous resin, C₁₀H₁₆O₂                 38
    Euphorbon, C₁₃H₂₂O                        22
    Mucilage                                  18
    Malates, chiefly of calcium and sodium    12
    Mineral compounds                         10
                                           ------
                                             100

The amorphous resin is readily soluble in cold spirit of wine
containing about 70 per cent. of alcohol. The solution has no acid
reaction, but an extremely burning acrid taste: in fact it is to the
amorphous indifferent resin that euphorbium owes its intense acridity.
By evaporating the resin with alcoholic potash and neutralizing the
residue with a dilute aqueous acid, a brown amorphous substance, the
_Euphorbic Acid_ of Buchheim,[2082] is precipitated. It is devoid of
the acridity of the resin from which it originated, but has a bitterish
taste.

From the drug deprived of the amorphous resin as above stated, ether
(ether or petroleum) takes up the _Euphorbon_, which may be obtained
in colourless, although not very distinct crystals, which are at
first not free from acrid taste. But by repeated crystallizations
and finally boiling in a weak solution of permanganate of potassium,
they may be so far purified as to be entirely tasteless. Euphorbon is
insoluble in water; it requires about 60 parts of alcohol, sp. gr.
0·830, for solution at the ordinary temperature. In boiling alcohol
euphorbon dissolves abundantly, also in ether, benzol, amylic alcohol,
chloroform, acetone, or glacial acetic acid.

Euphorbon melts at 116° C. (113° to 114°, Hesse) without emitting
any odour. By dry distillation a brownish oily liquid is obtained,
which claims further examination. If euphorbon dissolved in alcohol
is allowed to form a thin film in a porcelain capsule, and is then
moistened with a little concentrated sulphuric acid, a fine violet hue
is produced in contact with strong nitric acid slowly added by means
of a glass rod. The same reaction is displayed by _Lactucerin_ (see
Lactucarium), to which in its general characters euphorbon is closely
allied.

[2080] By careful investigation a very few are found at last.

[2081] Flückiger in Wittstein’s _Vierteljahresschrift für prakt.
Pharmacie_, xvii. (1868) 82-102.—The drug analysed consisted of
selected fragrants, free from extraneous substances.

[2082] Wiggers and Husemann, _Jahresbericht_, 1873. 559.

Hesse (1878) assigns to euphorbon the formula C₁₅H₂₄O, and points out
that its solutions in chloroform or ether are dextrogyrate.

As to the mucilage of euphorbium, it may be obtained from that portion
of the drug which has been exhausted by cold alcohol and by ether.
Neutral acetate of lead, as well as silicate or borate of sodium,
precipitate this mucilage, which therefore does not agree with gum
arabic.

If an aqueous extract of euphorbium is mixed with spirit of wine,
and the liquid evaporated, the residual matter assumes a somewhat
crystalline appearance, and exhibits the reactions of _Malic Acid_.
Subjected to dry distillation, white scales and acicular crystals of
_Maleic_ and _Fumaric Acids_, produced by the decomposition of the
malic acid, are sublimed into the neck of the retort. A sublimate of
the same kind may sometimes be obtained directly by heating fragments
of euphorbium. Among the mineral constituents of the drug, chloride of
sodium and calcium are noticeable; scarcely any salt of potassium is
present.

=Commerce=—The drug is shipped from Mogador. The quantity imported into
the United Kingdom in 1870 is given in the _Annual Statement of Trade_
as 12 cwt.

_Uses_—Euphorbium was formerly employed as an emetic and purgative,
but as an internal remedy it is completely obsolete. We have been told
that it is now in some demand as an ingredient of a paint for the
preservation of ships’ bottoms.


CORTEX CASCARILLÆ.

_Cortex Eleutheriæ_; _Cascarilla Bark_, _Sweet Wood Bark_,
_Eleuthera[2083] Bark_; F. _Ecorce de Cascarille_; G. _Cascarill-Rinde_.

=Botanical Origin=—_Croton Eluteria_ Bennett,[2084] a shrub or small
tree, exclusively native of the Bahama Islands.

=History=—It is not improbable that cascarilla bark was imported
into Europe in the first half of the 17th century, as there was much
intercourse subsequent to the year 1630 between England and the
Bahamas.[2085] These islands were occupied in 1641 by the Spaniards,
who became at that time acquainted with the Peruvian bark or Cascarilla
(see page 346), as we have shown at page 343. The external appearance
of the bark of Eluteria being somewhat similar to that of Cinchona
quills, the former began soon to be known under the name of _China
nova_. This drug occurs along with true Cinchona bark, _China de
China_, in the tariff of the year 1691 of the pharmaceutical shops of
the German town Minden, in Westphalia. There can be no doubt that the
cheaper kind of “China,” called China nova, was really the bark under
examination, for in many other tariffs a few years later distinct
mention is made of _Cortex Chinæ novæ seu Schacorillæ_; and Savary,
in his “Dictionnaire de Commerce” (1723, 1750), confirms the fact,
adding that it was first seen in the great fair of Brunswick.[2086]
Another early statement concerning Cascarilla bark likewise refers to
the duchy of Brunswick. Stisser, a professor of anatomy, chemistry,
and medicine in the University of Helmstedt in Brunswick, relates
that he received the drug under the name of _Cortex Eleuterii_ from a
person who had returned from England, in which country, he was assured,
it was customary to mix it with tobacco for the sake of correcting
the smell of the latter when smoked. He also mentions that it had
been confounded with Peruvian bark, from which however it was very
distinct in odour, etc.[2087] Eleutheria bark was then frequently
prescribed as a febrifuge in the place of Cinchona bark, then a more
expensive medicine. Hence the name _cascarilla_, signifying in Spanish
_little bark_, which was the customary designation of Peruvian bark,
was erroneously applied to the Bahama bark, until at last it quite
superseded the original and more correct appellation. That of _China
nova_ was subsequently applied to a quite different bark (see page
364). The drug under notice was first introduced into the London
Pharmacopœia in 1746 as _Eleutheriæ Cortex_, which was its common name
among druggists down to the end of the last century. In the Bahamas the
name _cascarilla_ is still hardly known, the bark being there called
either _Sweet Wood Bark_ or _Eleuthera Bark_.

[2083] From Eleuthera, one of the Bahama Islands, so named from the
Greek ἐλεύθερος, signifying _free_ or _independent_.

[2084] Bentley and Trimen’s _Med. Plants_, part i. (1875).

[2085] In that year a patent was granted by Charles I. for the
incorporation of a Company for colonizing the Bahama Islands, and
a complete record is extant of the proceedings of the Company for
the first eleven years of its existence. In some of the documents,
particular mention is made of the introduction, actual or attempted,
of useful plants, as cotton, tobacco, fig, pepper, pomegranate, palma
Christi, mulberry, flax, indigo, madder, and jalap; and there is also
frequent allusion to the importation of the produce of the islands, but
no mention of _Cascarilla_. See _Calendar of State Papers_, Colonial
Series, 1574-1660, edited by Sainsbury, Lond. 1860. pp. 146. 148. 149.
164. 168. 185. etc.

[2086] Flückiger, _Pharm. Journ._, vi. (1876) 1022, and “Documente”
quoted there, pp. 74-77, etc.

[2087] Stisser (J. A.) _Actorum Laboratorii Chemici specimen secundum_,
Helmestadi, 1693. c. ix. Stisser is said to have mentioned Cascarilla
bark in his pamphlet “De machinis fumiductoriis,” Hamburg, 1686, but
we found this to be incorrect. Nor have we seen the paper of Vincent
Garcia Salat, “Unica quæstiuncula, in qua examinatur pulvis de Burango,
vulgo _Cascarilla_, in curatione tertíanæ,” Valentiæ. 1692. It is
quoted by Haller, _Bibl. Bot._ ii. (1772) 688, and several later
authors, but appears to be extremely rare.

The plant affording cascarilla has been the subject of much discussion,
arising chiefly from the circumstance that several nearly allied West
Indian species of _Croton_ yield aromatic barks resembling more or less
the officinal drug. Catesby in 1754 figured a Bahama plant, _Croton
Cascarilla_ Bennett, from which the original _Eleuthera Bark_ was
probably derived, though it certainly affords none of the cascarilla
of modern commerce. Woodville in 1794, and Lindley in 1838, both
investigated the botany of the subject, the latter having the advantage
of authentic specimens communicated by the Hon. J. C. Lees of New
Providence, to whom one of us also is indebted for a similar favour.
The question was not however finally set at rest until 1859, when J. J.
Bennett by the aid of specimens collected in the Bahamas by Daniell in
1857-8, drew up lucid diagnoses of the several plants which had been
confounded, and disentangled their intricate synonymy.[2088]

[2088] _Journal of Proceedings of Linn. Soc._ iv. (1860) Bot. 29.

=Description=—Cascarilla occurs in the form of tubular or channelled
pieces of a dull brown colour, somewhat rough and irregular, rarely
exceeding 4 inches in length by ½ an inch in diameter. The chief bulk
of that at present imported is in very small thin quills and fragments,
often scarcely an inch in length, and evidently stripped from very
young wood. The younger bark has a thin suberous coat easily detached,
blotched or entirely covered with the silvery white growth of a minute
lichen (_Verrucaria albissima_ Ach.), the perithecium of which appears
as small black dots. The older bark is more rugose, irregularly
tessellated by longitudinal cracks and less numerous transverse
fissures. Beneath the corky envelope the bark is greyish-brown.

The bark breaks readily with a short fracture, the broken surface
displaying a resinous appearance. It has a very fragrant odour,
especially agreeable when several pounds of it are reduced to coarse
powder and placed in a jar; it has a nauseous bitter taste. When
burned it emits an aromatic smell, and hence is a common ingredient in
fumigating pastilles.

=Microscopic Characters=—The suberous coat is made up of numerous
rows of tabular cells, the outermost having their exterior walls much
thickened. The mesophlœum exhibits the usual tissue, containing starch,
chlorophyll, essential oil, crystals of oxalate of calcium, and a
brown colouring matter. The latter assumes a dark bluish coloration
on addition of a persalt of iron. In the inner portion of that layer
ramified laticiferous vessels are also present. The liber consists of
parenchyme and of fibrous bundles, intersected by small medullary rays.
On the transverse section, the fibrous bundles show a wedge-shaped
outline; they are for the most part built up, not of true liber-fibres,
but of cylindrical cells having their transverse walls perforated
sieve-like (_vasa cribriformia_). The contents of the parenchymatous
part of the liber are the same as in the mesophlœum; as to the oxalate
of calcium, the variety of its crystals is remarkable.[2089]

[2089] For more particulars see Pocklington, _Pharm. Journ._ iii.
(1873) 664.

=Chemical Composition=—Cascarilla contains a volatile oil, which it
yields to the extent of 1·1 per cent. According to Völckel (1840),
it is a mixture of at least two oils, the more volatile of which is
probably free from oxygen. Gladstone (1872) assigns to the hydrocarbon
of cascarilla oil the composition of oil of turpentine. By examining
the oil optically we found it to have a weak rotatory power—some
samples deviated to the right, some to the left. The resin, in which
cascarilla is rich, has not yet been examined more exactly.

The bitter principle was isolated in 1845 by Duval, and called
_Cascarillin_. C. and E. Mylius (1873) have obtained it from a deposit
in the officinal extract, in microscopic prisms readily soluble in
ether or hot alcohol, very sparingly in water, chloroform or spirit
of wine. It melts at 205° C., is not volatile, nor a glucoside. Its
composition answers to the formula C₁₂H₁₈O₄.

=Commerce=—The bark is shipped from Nassau, the chief town of New
Providence (Bahamas), and is usually packed in sacks. The quantity
imported into the United Kingdom in 1870 was 12,261 cwt., valued at
£16,482. The exports from the Bahamas were 676 cwt. in 1875, and 1,093
cwt. in 1876.

=Uses=—Cascarilla is prescribed as a tonic, usually in the form of a
tincture or infusion.

=Adulteration=—A spurious cascarilla bark has lately been noticed
in the London market; it was imported from the Bahamas mixed with
the genuine, to which it bears a close similarity. The quills of
it resemble the larger quills of cascarilla; though covered with a
lichen, the latter has not the silvery whiteness of the _Verrucaria_
of cascarilla. The spurious bark has a suberous coat that does
not split off; its inner surface is pinkish-brown, and distinctly
striated longitudinally. In microscopic structure the bark may be said
to resemble cascarilla and still more copalchi. But it is at once
distinguishable by its numerous _roundish groups_ of sclerenchymatous
cells, which become very evident when thin sections are moistened with
ammonia, and then with solution of iodine in iodide of potassium. The
bark has an astringent taste, without bitterness or aroma; its tincture
is not rendered milky by addition of water, but is darkened by ferric
chloride,—in these respects differing from a tincture of cascarilla.
Mr. Holmes[2090] suggests that this spurious cascarilla is probably the
bark of _Croton lucidus_ L.

Copalchi Bark; Quina blanca of the Mexicans.

This drug is derived from _Croton niveus_[2091] Jacquin (_C.
Pseudo-China_ Schlechtendal), a shrub growing 10 feet high, native
of the West Indian Islands, Mexico, Central America, New Granada and
Venezuela. It has occasionally been imported into Europe, in quills
a foot or two in length, much stouter and thicker than those of
cascarilla, to which in odour and taste it nearly approximates. The
bark has a thin, greyish, papery suberous layer, which when removed
shows the surface marked with minute transverse pits, like the lines
made by a file; it has a short fracture.[2092]

Copalchi bark was examined by J. Eliot Howard,[2093] and found to
contain a minute proportion of a bitter alkaloid soluble in ether,
which resembled quinine in yielding a deep green colour when treated
with chlorine and ammonia, though it did not afford any characteristic
compound with iodine. Mauch,[2094] who also analysed the bark, could
not obtain from it any organic base. He extracted by distillation
the essential oil, which he found to consist of a hydrocarbon and an
organic acid,—the latter not examined; he likewise got from the bark an
uncrystallizable bitter principle, which proved to be not a glucoside.

[2090] _Pharm. Journ._ iv. (1874) 810.

[2091] De Candolle’s _Prodromus_, xv. part 2. (1862) 518; beautifully
figured in Hayne, _Arzneigewächse_, xiv. (1843) plate 2.

[2092] For more particulars see Oberlin and Schlagdenhauffen, _Journ.
de Pharm. 28_ (1878) 248.

[2093] _Pharm. Journ._ xiv. (1855) 319.

[2094] Wittstein’s _Vierteljahresschrift für prakt. Pharm._ xviii.
(1869) 161.


SEMEN TIGLII.

_Semen Crotonis_; _Croton Seeds_; F. _Graines de Tilly ou des
Moluques_, _Petits Pignons d’Inde_; G. _Purgirkörner_, _Granatill_.

=Botanical Origin=—_Croton Tiglium_[2095] L. (_Tiglium officinale_
Klotzsch), a small tree, 15 to 20 feet high, indigenous to the Malabar
Coast and Tavoy, cultivated in gardens in many parts of the East, from
Mauritius to the India Archipelago. The tree has small inconspicuous
flowers, and brown, capsular, three-celled fruits, each cell containing
one seed. The leaves have a disagreeable smell and nauseous taste.

=History=—In Europe, the seeds and wood of the tree were first
described in 1578 by Christoval Acosta—the former, with a figure of the
plant, appearing under the name of _Piñones de Maluco_.[2096] The plant
was also described and figured by Rheede (1679)[2097] and Rumphius
(1743).[2098] The seeds, which were officinal in the 17th century, but
had become obsolete, were recommended about 1812 by English medical
officers in India,[2099] and the expressed oil by Perry, Frost, Conwell
and others about 1821-24. The oil then in use was imported from India,
and was often of doubtful purity, so that some druggists felt it
necessary to press the seeds for themselves.[2100]

[2095] Fig. in Bentley and Trimen’s _Medic. Plants_, part 1 (1875).

[2096] _Tractado_, etc., Burgos, 1578. c. 48.—After speaking of the
virtues of the seeds, he adds—“tambien las buenas mugeres de aquellas
partes, amigas de sus maridos, les dă hasta quatro destos por la boca,
para embiar a los pobretos al otro mundo”!

[2097] _Hortus Malabaricus_, ii. tab. 33.

[2098] _Herbarium Amboinense_, iv. tab. 42.

[2099] Ainslie, Mat. _Med. of Hindoostan_, 1813. 292.

[2100] The oil was very expensive. I find by the books of Messrs. Allen
and Hanburys, that the seeds cost in 1824, 10s., and in 1827, 18s. per
lb. The oil was purchased in 1826 by the same house at 8_s._ to 10_s._
per ounce.—D. H.

=Description=—Croton seeds are about half an inch long, by nearly ⅖ of
an inch broad, ovoid or bluntly oblong, divided longitudinally into
two unequal parts, of which the more arched constitutes the dorsal
and the flatter the ventral side. From the hilum, a fine raised line
(raphe) passes to the other end of the seed, terminating in a darker
point, indicating the chalaza. The surface of the seed is more or less
covered with a bright cinnamon-brown coat, which when scraped shows the
thin, brittle, black testa filled with a whitish, oily kernel, invested
with a delicate seed-coat. The kernel is easily split into two halves
consisting of oily albumen, between which lie the large, veined, leafy
cotyledons and the radicle. The taste of the seed is at first merely
oleaginous, but soon becomes unpleasantly and persistently acrid.

=Microscopic Structure=—The testa consists of an outer layer of
radially arranged, much elongated and thick-walled cells; the inner
parenchymatous layer contains small vascular bundles. The soft tissue
of the albumen is loaded with drops of fatty oil. If this is removed
by means of ether and weak potash lye, there remain small granules of
albuminoid matter, the so-called _Aleuron_, and crystals of oxalate of
calcium.

=Chemical Composition=—The principal constituent of croton seeds is the
fatty oil, the _Oleum Crotonis_ or _Oleum Tiglii_ of pharmacy of which
the kernels afford from 50 to 60 per cent. That used in England is for
the most part expressed in London, and justly regarded as more reliable
than that imported from India, with which the market was formerly
supplied. It is a transparent, sherry-coloured, viscid liquid, slightly
fluorescent, and having a slight rancid smell and an oily, acrid taste.
Its solubility in alcohol (·794) appears to depend in great measure on
the age of the oil, and the greater or less freshness of the seeds from
which it was expressed,—oxidized or resinified oil dissolving the most
readily.[2101] We found the oil which one of us had extracted by means
of bisulphide of carbon to be levogyre.

Croton oil consists chiefly of the glycerinic ethers of the common
fatty acids, such as stearic, palmitic, myristic and lauric acids. They
partly separate in the cold; the acids also may partly be obtained by
passing nitrous acid through croton oil. There are also present in the
latter, in the form of glycerinic ethers, the more volatile acids, as
formic, acetic, isobutyric and one of the valerianic acids.[2102] The
volatile part of the acids yielded by croton oil contains moreover an
acid which was regarded by Schlippe (1858) as angelic acid, C₅H₈O₂.
Yet in 1869 it was shown by Geuther and Frölich to be a peculiar
acid, which they called _Tiglinic acid_. Its composition answers to
the same formula, C₄H₇COOH, as that of angelic acid; but the melting
points (angelic acid 45°, tiglinic 64° C.) and boiling points (angelic
acid 185°, tiglinic 198°·5) are different. Both these acids have been
mentioned in our article on Flores Anthemidis, at page 386. Tiglinic
acid may also be obtained artificially; it is the methylcrotonic acid
of Frankland and Duppa (1865).

Schlippe also stated croton oil to afford a peculiar liquid acid termed
_Crotonic Acid_, C₄H₆O₂. According to Geuther and Frölich, however, an
acid of this formula does not occur at all in croton oil. By synthetic
methods three different acids of that composition are obtainable.

The _drastic principle_ of croton oil has not yet been isolated.
Buchheim[2103] suggested that the action of the oil depends
upon “_Crotonoleic acid_,” which however he failed in isolating
satisfactorily. It is remarkable that the wood and leaves of _Croton
Tiglium_ appear to partake also of the drastic properties of the seeds.

Schlippe asserts that he has separated the _vesicating matter_ of
croton oil: if the oil be agitated with alcoholic soda, and afterwards
with water, the supernatant liquor will be found free from acridity,
while the alcoholic solution will yield, on addition of hydrochloric
acid, a small quantity of a dark brown oil, called _Crotonol_,
possessing vesicating properties. We have not succeeded in obtaining
it, nor, so far as we know, has any other chemist except its discoverer.

The shells of the seeds (testa) yield upon incineration 2·6 per cent.
of ash; the kernels dried at 100° C. 3·0 per cent.

=Commerce=—The shipments of croton seeds arrive chiefly from Cochin or
Bombay, packed in cases, bales or robbins; but there are no statistics
to show the extent of the trade.

[2101] Warrington, _Pharm. Journ._ vi. (1865) 382-387.

[2102] Schmidt and Berendes, 1878.

[2103] In the _Jahresbericht_ of Wiggers and Husemann, 1873. 560.

=Uses=—Croton seeds are not administered. The oil is given internally
as a powerful cathartic, and is applied externally as a rubefacient.

=Substitutes=—The seeds of _Croton Pavanæ_ Hamilton, a native of Ava
and Camrup (Assam), and those of _C. oblongifolius_ Roxb., a small
tree common about Calcutta, are said to resemble those of _C. Tiglium_
L., but we have not compared them. Those of _Baliospermum montanum_
Müll. Arg. (_Croton polyandrus_ Roxb.) partake of the nature of croton
seeds, and according to Roxburgh are used by the natives of India as a
purgative.


SEMEN RICINI.

_Semen Cataputiæ majoris_; _Castor Oil Seeds_, _Palma Christi Seeds_;
F. _Semence de Ricin_; G. _Ricinussamen_.

=Botanical Origin=—_Ricinus communis_ L., the castor oil plant, is a
native of India where it bears several ancient Sanskrit names.[2104] By
cultivation, it has been distributed through all the tropical and many
of the temperate countries of the globe. In the regions most favourable
to its growth, it attains a height of 40 feet. In the Azores, and the
warmer Mediterranean countries as Algeria, Egypt, Greece, and the
Riviera, it becomes a small tree, 10 to 15 feet high; while in France,
Germany, and the south of England, it is an annual herb of noble
foliage, growing to a height of 4 or 5 feet. In good summers, it ripens
seeds in England and even as far north as Christiania in Norway.

_Ricinus communis_ exhibits a large number of varieties, several of
which have been described and figured as distinct species. Müller,
after a careful examination of the whole series, maintains them as
a single species, of which he allows 16 forms, more or less well
marked.[2105]

=History=—The castor oil plant was known to Herodotus who calls it
Κίκι, and states that it furnishes an oil much used by the Egyptians,
in whose ancient tombs seeds of Ricinus are, in fact, met with.[2106]
At the period when Herodotus wrote, it would appear to have been
already introduced into Greece, where it is cultivated to the present
day under the same ancient name.[2107] The _Kikajon_ of the Book of
Jonah, rendered by the translators of the English Bible _gourd_, is
believed to be the same plant. Κίκι is also mentioned by Strabo as a
production of Egypt, the oil from which is used for burning in lamps
and for unguents.

[2104] The most ancient and most usual is _Eranda_; this word has
passed into several other Indian languages.

[2105] De Candolle, _Prodr._, xv. sect. 2. 1017.

[2106] _Journ. of Botany_, 1879, 54.

[2107] Heldreich, _Nutzpflanzen Griechenlands_, Athen, 1862. 58.

Theophrastus and Nicander give the castor oil plant the name of Κρότων.
Dioscorides, who calls it Κίκι or Κρότων, describes it as of the
stature of a small fig-tree, with leaves like a plane, and seeds in a
prickly pericarp, observing that the name Κρότων is applied to the seed
on account of its resemblance to an insect [_Ixodes Ricinus_ Latr.],
known by that appellation. He also gives an account of the process for
extracting castor oil (Κίκινον ἔλαιον), which he says is not fit for
food, but is used externally in medicine; he represents the seeds as
extremely purgative. There is a tolerably correct figure of _Ricinus_
in the famous MS. Dioscorides which was executed for the Empress
Juliana Anicia in A.D. 505, and is now preserved in the Imperial
Library at Vienna.

The castor oil plant was cultivated by Albertus Magnus, Bishop of
Ratisbon, in the middle of the 13th century.[2108] It was well known as
a garden plant in the time of Turner (1568), who mentions the oil as
_Oleum cicinum vel ricininum_.[2109] Gerarde, at the end of the same
century, was familiar with it under the name of _Ricinus_ or _Kik_. The
oil he says is called _Oleum cicinum_ or _Oleum de Cherua_,[2110] and
used externally in skin diseases.

After this period the oil seems to have fallen into complete
neglect, and is not even noticed in the comprehensive and accurate
_Pharmacologia_ of Dale (1693). In the time of Hill (1751) and Lewis
(1761) Palma Christi seeds were rarely found in the shops, and the oil
from them was scarcely known.[2111]

In 1764 Peter Canvane, a physician who had practised many years in the
West Indies, published a “_Dissertation on the Oleum Palmæ Christi,
sive Oleum Ricini; or (as it is commonly call’d) Castor Oil_,”[2112]
strongly recommending its use as a gentle purgative. This essay, which
passed through two editions, and was translated into French, was
followed by several others,[2113] thus thoroughly drawing attention to
the value of the oil. Accordingly we find that the seeds of _Ricinus_
were admitted to the London Pharmacopœia of 1788, and directions given
for preparing oil from them. Woodville in his _Medical Botany_ (1790)
speaks of the oil as having “_lately come into frequent use_.”

At this period and for several years subsequently, the small supplies
of the seeds and oil required for European medicine were obtained from
Jamaica.[2114] This oil was gradually displaced in the market by that
produced in the East Indies: the rapidity with which the consumption
increased may be inferred from the following figures, representing
the value of the Castor Oil shipped to Great Britain from Bengal in
three several years, namely 1813-14, £610; 1815-16, £1269; 1819-20,
£7102.[2115]

[2108] _De Vegetabilibus_, ed. Jessen, 1867. 347.

[2109] Turner’s _Herbal_, pt. ii. 116.

[2110] From the Arabic _khirva_, _i.e._ Palma Christi.

[2111] Hill, _Hist. of the Mat. Med._, Lond. 1751. 537.—Lewis, _Hist.
of the Mat. Med._, Lond. 1761. 468.

[2112] The word _castor_ in connection with the seeds and oil of
_Ricinus_ has come to us from Jamaica, in which island, by some strange
mistake, the plant was once called _Agnus Castus_. The true Agnus
Castus (_Vitex Agnus castus_ L.) is a native of the Mediterranean
countries and not of the West Indies.

[2113] For a list of which consult Mérat et De Lens, _Dict. de Mat.
Méd._ vi. (1834) 95.

[2114] How small was the traffic in Castor Oil in those days, may be
judged from the fact that the stock in 1777 of a London wholesale
druggist (Joseph Gurney Bevan, predecessor of Allen and Hanburys) was
2 Bottles (1 Bottle = 18 to 20 ounces) valued at 8_s._ per bottle. The
accounts of the same house show at stocktaking in 1782, 23 Bottles of
the oil, which had cost 10_s._ per bottle. In 1799 Jamaica exported 236
Casks of Castor Oil and 10 Casks of seeds (Renny, _Hist. of Jamaica_,
1807. 235).

[2115] H. H. Wilson, _Review of the External Commerce of Bengal from
1813 to 1828_, Calcutta, 1830, tables pp. 14-15.

=Description=—The fruit of _Ricinus_ is a tricoccous capsule, usually
provided with weak prickles, containing one seed in each of its three
cells. The seeds attain a length of ³/₁₀ to ⁶/₁₀, and a maximum breadth
of ⁴/₁₀ of an inch, and are of a compressed ellipsoid form. The apex of
the seed is prolonged into a short beak, on the inner side of which
is a large tumid caruncle: from this latter proceeds the raphe as far
as the lower end of the ventral surface, where it forks, its point of
disappearance through the testa being marked by a minute protuberance.
If the caruncle is broken off, a black scar, formed of two little
depressions, remains.

The shining grey epidermis is beautifully marked with brownish bands
and spots, and in this respect exhibits a great variety of colours and
markings. It cannot be rubbed off, but may after maceration be peeled
off in leathery strips. The black testa, grey within, is not thicker
than in croton seed, but is much more brittle. The kernel or nucleus
fills the testa completely, and is easily separated, still covered by
the soft white inner membrane.

The kernel in respect to structure and situation of the embryo, agrees
exactly with that of _Croton Tiglium_ (p. 565), excepting that the
somewhat gaping cotyledons of _Ricinus_ are proportionately broader,
and have their thick midrib provided with 2 or 3 pairs of lateral
veins. If not rancid, the kernel has a bland taste, with but very
slight acridity.

=Microscopic Structure=—The thin epidermis consists of pentagonal or
hexagonal porous tabular cells, the walls of which are penetrated
in certain spots by brownish colouring matter, whence the singular
markings on the seed. It is these cells only that become blackened when
a thin tangential slice is saturated with a solution of ferric chloride
in alcohol.

Beneath these tabular cells there is found in the unripe seed[2116] a
row of encrusted colourless cells, deposited in a radial direction on
the testa. In the mature seed this layer of cells is not perceptible,
and therefore appears to perish as the seed ripens. The testa itself is
built up of cylindrical, densely packed cells, 300 to 320 mkm. long,
and 6 to 10 mkm. in diameter. The kernel shares the structure of that
of _C. Tiglium_, but is devoid of crystals of oxalate of calcium. If
the endopleura of _Ricinus_ is moistened with dilute sulphuric acid,
acicular crystals of sulphate of calcium separate from it after a few
hours.

When thin slices of the kernel are examined under concentrated
glycerin, no drops of oil are visible, notwithstanding the abundance
of this latter; and it becomes conspicuous only by addition of much
water. Hence it is probable that the oil exists in the seed as a kind
of compound with its albuminoid contents.[2117] As to the latter,
they partly form in the albumen of _Ricinus_ beautiful octohedra or
tetrahedra, which are also found in many other seeds.[2118]

[2116] Gris, _Annales des Sciences Nat._, Bot., xv. (1861) 5-9.

[2117] Sachs, _Lehrbuch der Botanik_, 1874. 54.

[2118] For further particulars, see Trécul, _Ann. des Sc. Nat._, Bot.,
x.,(1858) 355; Radlkofer, _Krystalle proteinartiger Körper_, Leipzig,
1859. 61. and tab. 2 fig. 10; Pfeffer, _Proteïnkörner_ in Pringsheim’s
_Jahrbücher für wissenschaftliche Botanik_, viii. (1872) 429. 464.

=Chemical Composition=—The most important constituent of the seed is
the fixed oil, called _Castor Oil_, of which the peeled kernels afford
at most half of their weight.

The oil, if most carefully prepared from peeled and winnowed seeds by
pressure without heat, has but a slightly acrid taste, and contains
only a very small proportion of the still unknown drastic constituent
of the seeds. Hence the seeds themselves, or an emulsion prepared with
them, act much more strongly than a corresponding quantity of oil.
Castor oil, extracted by absolute alcohol or by bisulphide of carbon,
likewise purges much more vehemently than the pressed oil.

The castor oil of commerce has a sp. gr. of about 0·96, usually a pale
yellow tint, a viscid consistence, and a very slight yet rather mawkish
odour and taste. Exposed to cold, it does not in general entirely
solidify until the temperature reaches -18° C. In thin layers it dries
up to varnish-like film.

Castor oil is distinguished by its power of mixing in all proportions
with glacial acetic acid or absolute alcohol. It is even soluble in
four parts of spirit of wine (·838) at 15° C., and mixes without
turbidity with an equal weight of the same solvent at 25° C. The
commercial varieties of the oil however differ considerably in these as
well as in some other respects.

The optical properties of the oil demand further investigation, as we
have found that some samples deviate the ray of polarized light to the
right and others to the left.

By saponification castor oil yields several fatty acids, one of which
appears to be _Palmitic Acid_. The prevailing acid (peculiar to the
oil) is _Ricinoleic Acid_, C₁₈H₃₄O₃; it is solid below 0° C., does
not solidify in contact with the air by absorption of oxygen, and is
not homologous with oleic or linoleic acid, neither of which is found
in castor oil. Castor oil is nevertheless thickened if 6 parts of it
are warmed with 1 part of starch and 5 of nitric acid (sp. gr. 1·25),
_Ricinelaïdin_ being thus formed. From this _Ricinelaïdic Acid_ may
easily be obtained in brilliant crystals.

As to the albuminoid matter of the seed, Fleury (1865) obtained 3·23
per cent. of nitrogen which would answer to about 20 per cent. of such
substances. The same chemist further extracted 46·6 per cent. of fixed
oil, 2·2 of sugar and mucilage, besides 18 per cent. of cellulose.

Tuson in 1864, by exhausting castor oil seeds with boiling water,
obtained from them an alkaloid which he named _Ricinine_. He states
that it crystallizes in rectangular prisms and tables, which when
heated fuse, and upon cooling solidify as a crystalline mass; the
crystals may even be sublimed. Ricinine dissolves readily in water or
alcohol, less freely in ether or benzol. With mercuric chloride, it
combines to form tufts of silky crystals, soluble in water or alcohol.
Werner (1869) on repeating Tuson’s process on 30 lb. of Italian castor
oil seeds, also obtained a crop of crystals, which in appearance
and solubility had many of the characters ascribed to ricinine, but
differed in the essential point that when incinerated they left a
residuum of magnesia. Werner regarded them as the magnesium salt of a
new acid. Tuson[2119] repudiates the suspicion that ricinine may be
identical with Werner’s magnesium compound. E. S. Wayne of Cincinnati
(1874) found in the leaves of _Ricinus_ a substance apparently
identical with Tuson’s ricinine; but he considers that it has no claim
to be called an alkaloid.

[2119] _Chemical News_, xxii. (1870) 229.

The testa of castor oil seeds afforded us 10·7 per cent. of ash, one
tenth of which we found to consist of silica. The ash of the kernel
previously dried at 100 C. amounts to only 3·5 per cent.

=Production and Commerce=—Castor oil is most extensively produced in
India, where two varieties of the seeds, the large and the small, are
distinguished, the latter being considered to yield the better product.
In manufacturing the oil, the seeds are gentry crushed between rollers,
and freed by hand from husks and unsound grains. At Calcutta, 100 parts
of seed yield on an average 70 parts of cleaned kernels, which by the
hydraulic press afford 46 to 51 per cent. of their weight of oil; the
oil is afterwards subjected to a very imperfect process of purification
by heating it with water.[2120]

The exports of castor oil from Calcutta[2121] in the year 1870-71
amounted to 654,917 gallons, of which 214,959 gallons were shipped to
the United Kingdom. The total imports of castor oil into the United
Kingdom[2122] in the year 1870 were returned as 36,986 cwt. (about
416,000 gallons), valued at £82,490. Of this quantity, British India
(chiefly Bengal) furnished about two-thirds; and Italy 11,856 cwt.
(about 133,000 gallons), while a small remainder is entered as from
“other parts.” In 1876 the imports were 79,677 cwt., valued at £133,838.

_Italian Castor Oil_, which has of late risen into some celebrity, is
pressed from the seed of plants grown chiefly about Verona and Legnago,
in the north of Italy. The manufactory of Mr. Bellino Valeri at the
latter town produced in the year 1873, 1200 quintals of castor oil,
entirely from Italian seed. Two varieties of _Ricinus_ are cultivated
in these localities, the black-seeded Egyptian and the red-seeded
American; the latter yields the larger percentage, but the oil is not
so pale in colour. The seeds are very carefully deprived of their
integuments, and having been crushed, are submitted to pressure in
powerful hydraulic presses, placed in a room which in winter is heated
to about 21° C. The outflow of oil is further promoted by plates of
iron warmed to 32-38° C. being placed between the press-bags. The
peeled seeds yield about 40 per cent. of oil.[2123]

All the castor oil pressed in Italy is not pressed from Italian seed.
By an official return[2124] it appears that in the year 1872-73 there
were exported from Bombay to Genoa 1350 cwt. of castor oil seeds,
besides 2452 gallons of castor oil. There are no data to show what was
exported from the other presidencies of India in that year.

=Uses=—Castor oil is much valued as a mild and safe purgative; while
the commoner qualities are used in soap-making, and in India for
burning in lamps. The seeds are not now administered. The _leaves_ of
the plant applied in decoction to the breasts of women are said to
promote or even to occasion the secretion of milk. This property, which
has long been known to the inhabitants of the Cape Verd Islands,[2125]
was particularly observed by Dr. M’William about the year 1850. It has
even been found that the galactagogue powers of the plant are exerted
when the leaves are administered internally.

[2120] _Madras Exhibition of Raw Products, etc. of Southern
India_,—Reports by the Juries, Madras, 1856. 28.

[2121] _Annual Volume of Trade and Navigation for the Bengal Presidency
for 1870-71_, Calcutta, 1871. 119.

[2122] _Annual Statement of the Trade, etc. of the U.K. for 1870._—No
later returns.

[2123] H. Groves, _Pharm. Journ._ viii (1867) 250.

[2124] _Annual Statement of the Trade and Navigation of the Presidency
of Bombay for 1872-73_, part ii. 87. 88.

[2125] Frezier, _Voyage to the South Seas_, Lond. 1717. p. 13.—Turner
in his Herbal (1568) gives the plant an opposite character, for the
bruised leaves, says he, “swage the brestes or pappes swellinge wyth to
muche plenty of milke.”


KAMALA.

_Kamela_, _Glandulæ Rottleræ_.

=Botanical Origin=—_Mallotus philippinensis_[2126] Müller Arg.
(_Croton philippensis_ Lam., _Rottlera tinctoria_ Roxb., _Echinus
philippinensis_ Baillon), a large shrub, or small tree, attaining 20
or 45 feet in height, of very wide distribution. It grows in Abyssinia
and Southern Arabia, throughout the Indian peninsulas, ascending the
mountains to 5000 feet above the sea-level, in Ceylon, the Malay
Archipelago, the Philippines, the Loochoo islands, Formosa, Eastern
China and in North Australia, Queensland and New South Wales.

The tricoccous fruits of many of the _Euphorbiaceæ_ are clothed with
prickles, stellate hairs, or easily removed glands. This is especially
the case in the several species of _Mallotus_, most of which have the
capsules covered with stellate hairs, together with small glands. In
that under notice, the capsule is closely beset with ruby-like glands
which, when removed by brushing and rubbing, constitute the powder
known by the Bengali name of _Kamala_. These glands are not confined
to the capsule, but are scattered over other parts of the plant,
especially among the dense tomentum with which the under side of the
leaf is covered.

=History=—In India the glands of Mallotus have been long known, for
they have several ancient Sanskrit names: one of these is _Kapila_,
which as well as the Telugu _Kapila-podi_, is sometimes used by
Europeans, though not so frequently as the word _Kamala_ or _Kamela_,
which belongs to the Hindustani, Bengali and Guzratti languages. The
Sanskrit word _Kapila_ signifies tawny or dusky red, the Tamil _Podi_
means the pollen of a flower or dust in general.

It does not appear that as a drug the glandular powder of _Mallotus_,
or as it is more conveniently called, _Kamala_, attracted any
particular notice in Europe until a very recent period, though it is
named by Ainslie, Roxburgh, Royle and Buchanan, the last of whom gives
an interesting account of its collection and uses.[2127] In 1852,
specimens of it as found in the bazaar of Aden, under the old Arabic
name of _Wars_, were sent to one of us by Port-Surgeon Vaughan, with
information as to its properties as a dye for a silk and as a remedy
in cutaneous diseases.[2128] But the real introduction of the drug as
a useful medicine is due to Mackinnon, surgeon in the Bengal Medical
Establishment, who administered it successively in numerous cases of
tapeworm. Anderson of Calcutta, C. A. Gordon, and Corbyn in India, and
Leared in London, confirmed the observations of Mackinnon, and fully
established the fact that kamala is an efficient taenifuge.[2129] It
was introduced into the _British Pharmacopœia_ in 1864.

[2126] Fig. in Bentley and Trimen’s _Med. Plants_, part i. (1875.)—A
beautiful figure in Roxburgh, _Plants of the Coast of Coromandel_, ii.
(1798) tab. 168.

[2127] _Journey through Mysore, Canara_, etc., (Lond. 1807) i. 168.
204. 211, ii. 343.

[2128] Hanbury, _Pharm. Journ._ xii. (1853) 386. 589; or _Science
Papers_, 73.

[2129] _Ibid._ xvii. (1858) 408; _Science Papers_, 75.

An analogous drug is mentioned by Paulus Ægineta[2130] in the 7th
century as well as by the Arabian physicians[2131] as early as the
10th century, under the name of _Kanbil_ or _Wars_. Ibn Khurdádbah,
an Arab geographer, living A.D. 869-885, states that from Yemen come
striped silks, ambergris, _wars_, and gum.[2132] It is described to
be a reddish yellow powder like sand, which falls on the ground in
the valleys of Yemen, and is a good remedy for tapeworm and cutaneous
diseases. One writer compares it to powdered saffron; another speaks of
two kinds,—an Abyssinian which is _black_ (or violet), and an Indian
which is _red_. Masudi,[2133] in the first half of the 10th century
speaks of _qinbil_, which he says consists of sandy fruits of red
hue. They are useful as an anthelminthic and for cutaneous diseases.
A similar explanation of the qinbil is found in Qamus, a dictionary
writer in the 13th century in Yemen. About the year 1216, a learned
traveller, Abul Abbas Ahmad Annabati,[2134] (Annabati = the botanist)
or Abul Abbas el-Nebáti, who was a native of Seville, remarks that
the drug is known in the Hejaz and brought from Yemen, but that it is
unknown in Andalusia and does not grow there.

Kazwini,[2135] nearly at the same period, was also acquainted with
_wars_, a plant _sown_ in Yemen and resembling Sesam; Constantinus
Africanus likewise mentioned “_huars_.” Wars, Wors, Wurrus or Warras in
Arabia properly signifies saffron.

In modern times, we find Niebuhr[2136] speaks of the same substance
(as “_wars_”), stating it to be a dye-stuff, of which quantities are
conveyed from Mokha to Oman.

=Production=—Kamala is one of the minor products of the Government
forests in the Madras Presidency, but is also collected in many other
parts of India. The following particulars have been communicated to us
by a correspondent[2137] in the North-west Provinces:—

“ ... Enormous quantities of _Rottlera tinctoria_ are found growing
at the foot of these hills, and every season numbers of people,
chiefly women and children, are engaged in collecting the powder for
exportation to the plains. They gather the berries in large quantities
and throw them into a great basket in which they roll them about,
rubbing them with their hands so as to divest them of the powder, which
falls through the basket as through a sieve, and is received below
on a cloth spread for the purpose. This powder forms the _Kamala_ of
commerce, and is in great repute as an anthelminthic, but is most
extensively used as a dye. The adulterations are chiefly the powdered
leaves, and the fruit-stalks with a little earthy matter, but the
percentage is not large. The operations of picking the fruit and
rubbing off the powder commence here in the beginning of March and last
about a month....”

[2130] Adams’ translat. iii. 457.

[2131] Quoted by Ibn Baytar,—see Sontheimer’s translation, ii. (1842)
326. 585.

[2132] Ibn Khordadbeh, _Livre des routes etc.—Journ. Asiatique_, v.
(1865) 295.

[2133] _Les Prairies d’or_, i. (Paris, 1861) 367.

[2134] Quoted by Ibn Baytar.

[2135] Ed. Lichtenfels, i. (Göttingen, 1849).

[2136] _Description de l’Arabie_, 1774. 133.

[2137] F. E. G. Matthews, Esq., of Nainee Tal.

A similar powder is collected in Southern Arabia, whence it is shipped
to the Persian Gulf and Bombay. It is also brought, under the name of
_Wars_, from Hurrur, a town in Eastern Africa, which is a great trading
station between the Galla countries and Berbera.[2138] Yet the Arabian
and African drug consists in most cases not of kamala, but of those
dark glands which we describe further on, at p. 575.

[2138] Burton, _Journ. of R. Geogr. Society_, xxv. (1855) 146.
Haggenmacher, _Reise in das Somaliland_, in Petermann’s _Geogr.
Mittheilungen_, Ergänzungsheft, xlvii. (1874) 39.

=Description=—Kamala is a fine, granular, mobile powder, consisting of
transparent, crimson granules, the bright colour of which is mostly
somewhat deadened by the admixture of grey stellate hairs, minute
fragments of leaves and similar foreign matter. It is nearly destitute
of taste and smell, but an alcoholic solution poured into water emits
a melon-like odour. Kamala is scarcely acted on by water, even at a
boiling heat; on the other hand, alcohol, ether, chloroform or benzol
extract from it a splendid red resin. Neither sulphuric nor nitric acid
acts upon it in the cold, nor does oil of turpentine become coloured by
it unless warmed. It floats on water, but sinks in oil of turpentine.
When sprinkled over a flame, it ignites after the manner of lycopodium.
Heated alone, it emits a slight aromatic odour; if pure, it leaves
after incineration about 1·37 per cent. of a grey ash.

=Microscopic Structure=—The granules of kamala are irregular spherical
glands, 50 to 60 mkm. in diameter; they have a wavy surface, are
somewhat flattened or depressed on one side, and enclose within their
delicate yellowish membrane a structureless yellow mass in which are
imbedded numerous, simple, club-shaped cells containing a homogeneous,
transparent, red substance. These cells are grouped in a radiate manner
around the centre of the flattened side, so that on the side next the
observer, 10 to 30 of them may easily be counted, while the entire
gland may contain 40 to 60. In a few cases, a very short stalk-cell is
also seen at the centre of the base.

When the glands are exhausted by alcohol and potash, and broken by
pressure between flat pieces of glass, they separate into individual
cells which swell up slightly, while the membranous envelope is
completely detached, and appears as a simple coherent film. After
this treatment the cells, but not their membranous envelope, acquire
by prolonged contact with strong sulphuric acid and iodine water
a more or less brown or blue colour: the walls of the cells alone
correspond therefore to cellulose. Vogl (1864) supposes that a cell of
the epidermis of the fruit first develops a young cellule, which by
partition is resolved into the stalk-cell and the true mother-cell of
the small clavate resin-cellules. At first, the contents of the latter
do not differ from the mass in which they are imbedded, and perhaps
pass gradually into resin by metamorphosis of the cellular substance.

The glands of kamala are always accompanied by colourless or brownish,
thick-walled, stellate hairs, two or three times as long as the glands,
often containing air, which do not exhibit any peculiarity of form, but
resemble the hairs of other plants, as _Verbascum_ or _Althæa_.

=Chemical Composition=—Kamala has been analysed by Anderson of Glasgow
(1855) and by Leube (1860). From the labours of these chemists, it
appears that the powder yields to alcohol or ether nearly 80 per cent.
of resin. We find it to be soluble also in glacial acetic acid or in
bisulphide of carbon, not in petroleum ether. By treatment of the resin
extracted by ether with cold alcohol, Leube resolved it into two
brittle reddish yellow resins, of which the one is more easily soluble
and fuses at 80° C., and the other dissolves less readily and fuses at
191°. Both dissolve in alkaline solutions, and can be precipitated by
acids without apparent change.

Anderson found that a concentrated ethereal solution of kamala
allowed to stand for a few days, solidified into a mass of granular
crystals, which by repeated solution and crystallization in ether
were obtained in a state of purity. This substance, named by Anderson
_Rottlerin_,[2139] forms minute, platy, yellow crystals of a fine
satiny lustre, readily soluble in ether, sparingly in cold alcohol,
more so in hot, and insoluble in water. The mean of four analyses gave
the composition of rottlerin as C₂₂H₂₀O₆.

We have been able to confirm the foregoing observations so far as that
we have obtained an abundance of minute acicular crystals, by allowing
an ethereal solution of kamala to evaporate spontaneously to a syrupy
state. But the purification of these crystals, which was also attempted
by our friend Mr. T. B. Groves,[2140] was unsuccessful, for when freed
from the protecting mother-liquor, they underwent a change and assumed
an amorphous form. We have, on the other hand, succeeded in isolating
the crystals from the “_Kamalin_,” as sold by E. Merck of Darmstadt. By
fusing them with caustic potash we obtained paraoxy-benzoic acid (see
page 408).

=Uses=—The drug is administered for the expulsion of tapeworm; it has
also been used as an external application in _herpes circinnatus_. In
India it is employed for dyeing silk a rich orange-brown.

=Adulteration=—Kamala is very liable to adulteration with earthy
substances, even to the extent of 60 per cent. This contamination may
easily be known by the grittiness of the drug, and by a portion of it
sinking when it is stirred up with water, but in the most decisive
manner by incineration. Sometimes kamala contains an undue proportion
of foreign vegetable matter, as remains of the capsules, leaves, etc.,
which can partly be separated by a lawn sieve. We have met with a large
quantity of very impure Kamala in the London market (1878), which was
offered for cleaning polished metallic surfaces.

=Substitute=—A very remarkable form of so-called kamala was imported
in 1867 from Aden by Messrs. Allen and Hanburys, druggists, of
London.[2141] It arrived neatly packed in oblong, white calico bags,
of three sizes, each inscribed with Arabic characters, indicating
with the name of the vendor or collector, a native of Hurrur, the net
weight, which was either 100, 50, or 25 Turkish ounces. No more than
two supplies, in all 136 lb., could be obtained.

[2139] See _Science Papers_, 78.

[2140] _Yearbook of Pharmacy_, 1872. 599.

[2141] It has been particularly described by one of us in _Pharm.
Journ._ ix. (1868) 279, with woodcuts.

The drug was in coarser particles than kamala, of a deep purple, and
had a distinct odour resembling that which is produced when a tincture
of kamala is poured into water. It had been carefully collected and was
free from earthy admixture, yet it left upon incineration 12 per cent.
of ash. Under the microscope it presented still greater differences,
the grains being cylindrical or subconical, 170 to 200 mkm. long,
by 70 to 100 mkm. broad, with _oblong_ resin-cells, arranged
perpendicularly in three or four storeys; mixed with the grains were
a few long, simple hairs. Another fact of some interest is, that at a
temperature of 93° to 100° C., this drug becomes quite black, while
kamala undergoes no change of colour.

In 1878 our friend Professor Schär was informed by a Swiss firm,
Messrs. Furrer and Escher of Aden, that Kanbil, Qinbil or Kamala are
unknown there. But they sent under the name of _Vars_ a powder, which
Prof. Schär as well as one of us (F.) find identical with the drug
which had been imported by Messrs. Allen and Hanbury. Prof. Schär was
also informed that Vars is used chiefly in the coast districts of
Mascat (Oman) and Hadramaut, in skin diseases, for expelling the tape
worm and as a dye.

Thus the appellation Wurrus or Waras is to be restricted to the dark
purple or violet glands occurring in eastern Africa and Yemen, although
the Waras sent to one of us[2142] by Vaughan was kamala.

As to the mother plant of Waras[2143] we have no information to offer;
we attempted in vain to ascertain its origin. It is evident that it is
the “black Abyssinian” powder already alluded to at page 573.




PIPERACEÆ.


FRUCTUS PIPERIS NIGRI.

_Piper nigrum_; _Black Pepper_; F. _Poivre noir_; G. _Schwarzer
Pfeffer_.

=Botanical Origin=—_Piper nigrum_ L.—The pepper plant is a perennial
climbing shrub, with jointed stems branching dichotomously, and broadly
ovate, 5-to 7-nerved, stalked leaves. The slender flower-spikes are
opposite the leaves, stalked, and from 3 to 6 inches long; and the
fruits are sessile and fleshy.

_Piper nigrum_ is indigenous to the forests of Travancore and Malabar,
whence it has been introduced into Sumatra, Java, Borneo, the Malay
Peninsula, Siam, the Philippines and the West Indies.

=History=—Pepper[2144] is one of the spices earliest used by mankind,
and although now a commodity of but small importance in comparison with
sugar, coffee, and cotton, it was for many ages the staple article
of trade between Europe and India. It would require in fact a volume
to give a full idea of the prominent importance of pepper during the
middle ages.

In the 4th century B.C., Theophrastus noticed the existence of two
kinds of pepper (πέπερι), probably the _Black Pepper_ and _Long Pepper_
of modern times. Dioscorides stated pepper to be a production of
India, and was acquainted with _White Pepper_ (λευκὸν πέπερι). Pliny’s
information on the same subject is curious; he tells us that in his
time a pound of long pepper was worth 15, of white 7, and of black
pepper 4 _denarii_; and expresses his astonishment that mankind should
so highly esteem pepper, which was neither a sweet taste nor attractive
appearance, or any desirable quality besides a certain pungency.

[2142] Hanbury, _Science Papers_, 73.

[2143] Some information will be met with in Capt. Hunter’s _Account of
Aden_, 1877. p. 107. In 1875-1876 there were exported from Aden 42,975
lb. of Waras.

[2144] The word _pepper_, which with slight varieties has passed into
almost all languages, comes from the Sanskrit name for _Long Pepper_,
_pippali_, the change of the _l_ into _r_ having been made by the
Persians, in whose ancient language the _l_ is wanting.

In the Periplus of the Erythrean Sea, written about A.D. 64, it is
stated that pepper is exported from Baraké, the shipping place of
Nelkunda, in which region, and there only, it grows in great quantity.
These have been identified with places on the Malabar Coast between
Mangalore and Calicut.[2145]

Long pepper and Black pepper are among the Indian spices on which the
Romans levied duty at Alexandria about A.D. 176.[2146]

Cosmas Indicopleustes,[2147] a merchant, and in later life a monk,
who wrote about A.D. 540, appears to have visited the Malabar Coast,
or at all events had some information about the pepper plant from an
eye-witness. It is he who furnishes the first particulars about it,
stating that it is a climbing plant, sticking close to high trees like
a vine. Its native country he calls _Male_.[2148] The Arabian authors
of the middle ages, as Ibn Khurdádbah (_circa_ A.D. 869-885), Edrisi in
the middle of the 12th, and Ibn Batuta in the 14th century, furnished
nearly similar accounts.

Among Europeans who described the pepper plant with some exactness,
one of the first was Benjamin of Tudela, who visited the Malabar Coast
in A.D. 1166. Another was the Catalan friar, Jordanus,[2149] about
1330; he described the plant as something like ivy, climbing trees and
forming fruit, like that of the wild vine. “This fruit,” he says, “is
at first green, then, when it comes to maturity, black.” Nearly the
same statements are repeated by Nicolo Conti, a Venetian, who at the
beginning of the 15th century, spent twenty-five years in the East.
He observed the plant in Sumatra, and also described it as resembling
ivy.[2150]

In Europe, pepper during the middle ages was the most esteemed and
important of all spices, and the very symbol of the spice trade, to
which Venice,[2151] Genoa, and the commercial cities of Central Europe
were indebted for a large part of their wealth; and its importance as a
means of promoting commercial activity during the middle ages, and the
civilizing intercourse of nation with nation, can scarcely be overrated.

[2145] Vincent, _Commerce and Navigation of the Ancients_, ii. (1807)
458.

[2146] Vincent, _op. cit._ ii. 754; also Meyer, _Geschichte der
Botanik_, ii. (1865) 167.

[2147] Migne, _Patrologiæ Cursus_, series Græca, lxxxviii. (1860) 443.
446.

[2148] _Bar_ (as in _Malabar_) merely signifies in Arabic, _coast_.

[2149] _Mirabilia descripta_ by Friar Jordanus, translated by Col.
Yule. London, Hakluyt Society, 1863. 27.

[2150] “Piperis arbor persimilis est ederæ, grana ejus viridia
ad formam grani juniperi, quæ modico cinere aspersa torrentur ad
solem.”—Kunstmann, _Kenntniss Indiens im xv. Jahrhundert_, München
(1863) 40.

[2151] In the beginning of the 15th century the great emporium of
the trade in pepper appears to have been the vicinity of the Church
S. Giacomo de Rialto at Venice. In the “capitolare dei Visdomini del
fontego dei Todeschi (German court) in Venezia,” edit. of Thomas,
Berlin, 1874, the chapter 228, page 116, is devoted to “_La mercadantia
del pevere_.”

Tribute was levied in pepper,[2152] and donations were made of this
spice, which was often used as a medium of exchange when money was
scarce. During the siege of Rome by Alaric, king of the Goths, A.D.
408, the ransom demanded from the city included among other things
5000 pounds of gold, 30,000 pounds of silver, and 3000 pounds of
_pepper_.[2153] After the conquest of Cæsarea in Palestine, A.D. 1101,
by the Genoese, each of them received two pounds of pepper and 48 soldi
for his part of the booty.[2154] Facts of this nature, of which a great
number might be enumerated, sufficiently illustrate the part played by
this spice in mediæval times.

The general prevalence during the middle ages of _pepper-rents_, which
consisted in an obligation imposed upon a tenant to supply his lord
with a certain quantity of pepper, generally a pound, at stated times,
shows how acceptable was this favourite condiment, and how great the
desire of the wealthier classes to secure a supply of it when the
market was not always certain.[2155]

The earliest reference to a trade in pepper in England that we have met
with, is in the Statutes of Ethelred, A.D. 978-1016,[2156] where it is
enacted that the Easterlings coming with their ships to Billingsgate
should pay at Christmas and Easter for the privilege of trading with
London, a small tribute of cloth, five pairs of gloves, _ten pounds of
pepper_,[2157] and two barrels of vinegar.

The merchants who trafficked in spices were called _Piperarii_,—in
English _Pepperers_, in French _Poivriers_ or _Pebriers_. As a
fraternity or guild, they are mentioned as existing in London in
the Reign of Henry II. (A.D. 1154-1189). They were subsequently
incorporated as the Grocers’ Company, and had the oversight and control
of the trade in spices, drugs, dye-stuffs, and even metals.[2158]

The price of pepper during the middle ages was always exorbitantly
high, for the rulers of Egypt extorted a large revenue from all those
who were engaged in the trade in it and other spices.[2159] Thus
in England between A.D. 1263 and 1399, it averaged 1_s._ per lb.,
equivalent to about 8_s._ of our present money. It was however about
2_s._ per lb. (= 16_s._) between 1350 and 1360.[2160] In 1370 we find
pepper in France valued 7 sous 6 deniers per lb. (= fr. 21. c. 30):—in
1542 at a price equal to fr. 11 per lb.[2161]

The high cost of this important condiment contributed to incite the
Portuguese to seek for a sea-passage to India. It was some time after
the discovery of this passage (A.D. 1498) that the price of pepper
first experienced a considerable fall; while about the same period the
cultivation of the plant was extended to the western islands of the
Malay Archipelago. The trade in pepper continued to be a monopoly of
the Crown of Portugal as late as the 18th century.

[2152] For some examples of this, see _Histoire de la vie privée des
Français_, par le Grand d’Aussy, nouvelle éd., ii. (1815) 182.

[2153] Zosimus, _Historia_ (Lips. 1784) lib. v. c. 41.

[2154] Belgrano, _Vita privata dei Genovesi_ 1875. 152.

[2155] Rogers, _Agriculture and Prices in England_, i. (1866) 626.
The term _peppercorn rent_, which has survived to our times, now only
signifies a nominal payment.

[2156] _Ancient Laws and Institutes of England_, published by the
Record Commission, i. (1840) 301.

[2157] A striking contrast to the announcement in a commercial paper,
27 _Feb._ 1874, that the stock of pepper in the public warehouses of
London the previous week was 6035 tons!

[2158] Herbert, _Hist. of the twelve great Livery Companies of London_,
Lond. 1834. 303, 310.

[2159] Reinaud, _Nouveau Journal asiatique_, 1829, Juillet, 22-51.

[2160] Rogers, _op. cit._ i. 641.

[2161] Leber, _Appréciation de la fortune privée au moyen-âge, éd._ 2,
Paris, 1847. 95, 305.

The Venetians used every effort to retain the valued traffic in their
own hands, but in vain; and it was a fact of general interest when on
the 21st of January 1522 a Portuguese ship brought for the first time
the spices of India direct to the city of Antwerp. Strange to say, they
were received with great mistrust!

Pepper was heavily taxed in England. In 1623 the imposts levied on it
amounted to 5_s._ per lb.; and even down to 1823 it was subject to a
duty of 2_s._ 6_d._ per lb.

=Production=—In the south-west of India, the plant, or _Pepper Vine_
as it is called, grows on the sides of the narrow valleys where the
soil is rich and moist, producing lofty trees by which a constant,
favourable coolness is maintained. In such places the pepper-vine runs
along the ground and propagates itself by striking out roots into the
soil. The natives tie up the end of the vines lying on the ground to
the nearest tree, on the bark of which the stems put out roots so far
as they have been tied, the shoots above that hanging down. The plant
is capable of growing to a height of 20 or 30 feet, but for the sake
of convenience it is usually kept low, and is often trained on poles.
In places where no vines occur naturally, the plant is propagated by
planting slips near the roots of the trees on which it is to climb.

The pepper plants if grown on a rich soil begin to bear even in the
first year, and continue to increase in productiveness till about the
fifth, when they yield 8 to 10 lb. of berries per plant, which is about
the average produce up to the age of 15 to 20 years; after this they
begin to decline.

When one or two berries at the base of the spike begin to turn red, the
whole spike is pinched off. Next day the berries are rubbed off with
the hands and picked clean; then dried for three days on mats, or on
smooth hard ground, or on bamboo baskets near a gentle fire.

In Malabar the pepper-vine flowers in May and June, and the fruits
become fit for gathering at the commencement of the following
year.[2162]

The largest quantities of pepper are produced in the island of Rhio,
near Singapore, in Djohor (in the south-eastern coast of the Malayan
Peninsula), and in Penang. The latter island affords on an average
about one-half of the total crop.

=Description=—The small, round, berry-like fruits grow somewhat loosely
to the number of 20 to 30, on a common pendulous fruit-stalk. They are
at first green, then become red, and if allowed to ripen, yellow; but
they are gathered before complete maturity, and by drying in that state
turn blackish grey or brown. If left until quite ripe they lose some of
their pungency, and gradually fall off.

The berries after drying are spherical, about ⅕ inch in diameter,
wrinkled on the surface, indistinctly pointed below by the remains of
the very short pedicel, and crowned still more indistinctly by the 3-or
4-lobed stigma. The thin pericarp tightly encloses a single seed, the
embryo of which in consequence of premature gathering is undeveloped,
and merely replaced by a cavity situated below the apex. The seed
itself contains within the thin red-brown testa a shining albumen, grey
and horny without, and mealy within. The pungent taste and peculiar
smell of pepper are familiar to all.

[2162] For a full account of the cultivation of pepper, see Buchanan,
_Journey from Madras through Mysore, Canara, and Malabar_, ii. (1807)
455-520; iii. 158.

=Microscopic Structure=—The transverse section of a grain of black
pepper exhibits a soft yellowish epidermis, covering the outer
pericarp. This is formed of a closely-packed yellow layer of large,
mostly radially arranged, thick-walled cells, each containing in its
small cavity a mass of dark brown resin. The middle layer of the
pericarp consists of soft, tangentially-extended parenchyme, containing
an abundance of extremely small starch granules and drops of oil. The
shrinking of this loose middle layer is the chief cause of the deep
wrinkles on the surface of the berry. The next inner layer of the
pericarp exhibits towards its circumference tangentially-arranged,
soft parenchyme, the cells of which possess either spiral striation or
spiral fibres, but towards the interior loose parenchyme, free from
starch, and containing very large oil-cells.

The testa is formed in the first place of a row of small yellow
thick-walled cells. Next to them follows the true testa, as a dense,
dark brown layer of lignified cells, the individual outlines of which
are undistinguishable.

The albumen of the seeds consists of angular, radially-arranged,
large-celled parenchyme. Most of its cells are colourless and loaded
with starch; others contain a soft yellow amorphous mass. If thin
slices are kept under glycerin for some time, these masses are slowly
transformed into needle-shaped crystals of piperin.

=Chemical Composition=—Pepper contains resin and essential oil, to the
former of which its sharp pungent taste is due. The essential oil has
more of the smell than of the taste of pepper.[2163] The drug yields
from 1·6 to 2·2 per cent. of this volatile oil, which agrees with oil
of turpentine in composition as well as in specific gravity and boiling
point. We find it, in a column 50 mm. long, to deviate the ray of
polarized light 1°·2 to 3°·4 to the left.

The most interesting constituent of pepper, _Piperin_, which pepper
yields to the extent of 2 to 8 per cent., agrees in composition with
the formula C₁₇H₁₉NO₃, like morphine. Piperin has no action on litmus
paper; it is not capable of combining directly with an acid, yet unites
with hydrochloric acid in the presence of mercuric and other metallic
chlorides, forming crystallizable compounds. It is insoluble in water;
when perfectly pure, its crystals are devoid of colour, taste and
smell. Its alcoholic solution is without action on polarized light.
Piperin may be resolved, as found by Anderson in 1850, into _Piperic
Acid_, C₁₂H₁₀O₄, and _Piperidine_, C₅H₁₁N. The latter is a liquid
colourless alkaloid, boiling at 106° C., having the odour of pepper and
ammonia, and directly yielding crystallizable salts.

Besides these constituents, pepper also contains some fatty oil in the
mesocarp. Of inorganic matter, it yields upon incineration from 4·1 to
5·7 per cent.

=Commerce=—Singapore is the great emporium for pepper, of which 197,478
peculs (26⅓ million lb.) were imported there in 1877. The largest part
of it finds its way to England. The import of pepper into the United
Kingdom during 1872, was 27,576,710 lb. valued at £753,970. Of this
quantity, the Straits Settlements supplied 25,000,000 lb., and British
India 256,000 lb. Of the quantity of 25,917,070 lb., imported in 1876
into Great Britain, the home consumption was 9 million lb.

[2163] As noticed by Rheede in 1688: “ ... oleum ex pipere destillatum
levem piperis odorem spirans, saporis parum acris.”—_Hort. Malab._
vii. 24.—The oil was however obtained long before by Valerius Cordus,
Guintherus Andernacensis and Porta (see our article Cortex Cinnamomi,
page 526).

The exports of pepper from the United Kingdom in 1872 amounted to
17,891,620 lb., the largest quantity being taken by Germany (5,201,574
lb.) Then follows Italy (2,288,647 lb.); and Russia, Holland and Spain,
each of which took more than a million pounds.[2164]

The varieties of pepper quoted in price-currents are _Malabar_,
_Aleppee and Cochin_, _Penang_, _Singapore_, _Siam_.

A large quantity is also shipped from Singapore to China, the imports
of that country in 1877 of both black and white pepper, being 53,844
peculs (7,179,200 lb.)

=Uses=—Pepper is not of much importance as a medicine, and is rarely if
ever prescribed, except indirectly as an ingredient of some preparation.

=Adulteration=—Whole pepper is not, we believe, liable in Europe to
adulteration;[2165] but the case is widely different as regards the
pulverized spice. Notwithstanding the enormous penalty of £100, to
which the manufacturer, possessor, or seller of adulterated pepper
is liable,[2166] and the low cost of the article, ground pepper has
hitherto been frequently sophisticated by the addition of the starches
of cereals and potatoes, of sago, mustard husks, linseed and capsicum.
The admixture of these substances may for the most part be readily
detected, after some practice, by the microscope.[2167]

White Pepper.

This form of the spice is prepared from black pepper by removing its
dark outer layer of pericarp, and thereby depriving it of a portion of
its pungency. It is mentioned by Dioscorides, yet was evidently very
little known in Europe even during the middle ages. In the time of
Platearius,[2168] white pepper was supposed to be derived from a plant
different from Piper nigrum.

Buchanan,[2169] referring to Travancore, remarks that white pepper is
made by allowing the berries to ripen; the bunches are then gathered,
and having been kept for three days in the house, are washed and
bruised in a basket with the hand till all the stalks and pulp are
removed.

The finest white pepper is obtained from Tellicherry, on the Malabar
Coast, but only in small quantity. The more important places for its
preparation are the Straits Settlements, chiefly Rhio. The export of
white pepper from Singapore in 1877 was 48,460 peculs. Most of the
spice finds its way to China, where it is highly esteemed. In Europe,
pepper in its natural state is with good reason preferred.

[2164] _Annual Statement of the Trade of the U.K. for 1872._ 59., 125.

[2165] According to Moodeen Sheriff (_Suppl. to Pharm. of India_,
134) the berries of _Embelia_ (Samara) _Ribes_, order _Myrsineæ_, are
said to be sometimes used for adulterating black pepper in the Indian
bazaars.

[2166] By the 59 George III. c. 53 § 22 (1819).

[2167] Consult, Hassall, _Food and its Adulterations_, Lond. 1855. 42;
Evans, _Pharm. Journ._ i. (1860) 605.

[2168] _Glossæ in antidotarium Nicolai._, ccxlvi. verso.

[2169] In the work quoted, page 579, ii. 465, 533, and iii. 224.

The grains of white pepper are of rather larger size than those of
black, and of a warm greyish tint. They are nearly spherical or a
little flattened. At the base the skin of the fruit is thickened into
a blunt prominence, whence about 12 light stripes run meridian-like
towards the depressed summit. If the skin is scraped off, the dark
brown testa is seen enclosing the hard translucent albumen. In
anatomical structure, as well as in taste and smell, white pepper
agrees with black, which in fact it represents in a rather more
fully-grown state.

White pepper appears to afford on an average not more than 1·9 per
cent. of essential oil, but to be richer in piperin, of which Cazeneuve
and Caillol (1877) extracted as much as 9 per cent. The amount of ash
yielded by white pepper is 1·1 per cent. on an average, that is to say,
considerably less than by black pepper.


FRUCTUS PIPERIS LONGI.

_Piper longum_; _Long Pepper_; F. _Poivre long_; G. _Langer Pfeffer_.

=Botanical Origin=—_Piper officinarum_ C. DC. (_Chavica[2170]
officinarum_ Miq.), a diœcious shrubby plant, with ovate-oblong
acuminate leaves, attenuated at the base, and having pinnate nerves.
It is a native of the Indian Archipelago, as Java, Sumatra, Celebes
and Timor. Long pepper is the fruit spike, collected and dried shortly
before it reaches maturity.

_Piper longum_ L.[2171] (_Chavica Roxburghii_ Miq.), a shrub indigenous
to Malabar, Ceylon, Eastern Bengal, Timor and the Philippines, also
yields long pepper, for the sake of which it is cultivated along the
eastern and western coasts of India. It may be distinguished from the
previous species by its 5-nerved leaves, cordate at the base.[2172]

=History=—A drug termed Πέπερι μακρὸν, _Piper longum_, was known to
the ancient Greeks and Romans, and may have been the same as the _Long
Pepper_ of modern times.

In the Latin verses bearing the name of Macer Floridus,[2173] which
were probably written in the 10th century, mention is made of Black,
White, and Long Pepper. The last named spice, or _Macropiper_, is
named by Simon of Genoa,[2174] who was physician to Pope Nicolas IV.
and chaplain to Boniface VIII. (A.D. 1288-1303), and travelled in the
East for the study of plants. Piper longum is also met with in the
list of drugs on which (A.D. 1305) duty was levied at Pisa.[2175]
Nicolo Conti of Venice, who lived in India from 1419 to 1444, noticed
Long Pepper.[2176] Saladinus[2177] in the middle of the 15th century
enumerates long pepper among the drugs necessary to be kept by
apothecaries and it has had a place in the pharmacopœias to the present
time.

[2170] The genus _Chavica_ separated from _Piper_ by Miquel, has been
re-united to it by Casimir de Candolle (_Prod._ xvi. s. 1). The latter
genus is now composed of not fewer than 620 species!

[2171] Fig. in Bentley and Trimen’s _Med. Plants_, part 18 (1877).

[2172] For good figures of the two plants, see Hayne’s
_Arzney-Gewächse_, xiv. (1843) tab. 20. 21.

[2173] Choulant, _Macer Floridus de Viribus Herbarum_, Lipsiæ, 1832.
114.

[2174] _Clavis Sanationis_, Venet. 1510.

[2175] Bonaini, _Statuti inediti della città di Pisa_, iii. (1857) 492.

[2176] Kunstmann, _Kenntniss Indiens im 15ᵗᵉⁿ Jahrhundert_, München,
1863. 40.

[2177] See Appendix.

=Production=—In Bengal the plants are cultivated by suckers, and
require to be grown on a rich, high and dry soil; they should be set
about five feet asunder. An English acre will yield in the first year
about three maunds (1 maund = 80 lbs.) of the pepper, in the second
twelve, and in the third eighteen; after which, as the plant becomes
less and less productive, the roots are grubbed up, dried, and sold
as _Pipli-múl_, of which there is a large consumption in India as a
medicine. The pepper is gathered in the month of January, when full
grown, and exposed to the sun until perfectly dry. After the fruit has
been collected, the stem and branches die down to the ground.[2178]

[2178] Roxburgh, _Flora Indica_, i. (1832) 155.

=Description=—Long pepper consists of a multitude of minute baccate
fruits, closely packed around a common axis, the whole forming a
spike of 1½ inch long and ¼ of an inch thick. The spike is supported
on a stalk ½ an inch long; it is rounded above and below, and tapers
slightly towards its upper end. The fruits are ovoid, ⅒ of an inch
long, crowned with a nipple-like point (the remains of the stigma), and
arranged spirally with a small peltate bract beneath each. A transverse
section of a spike exhibits 8 to 10 separate fruits, disposed radially
with their narrower end pointed towards the axis. Beneath the pericarp,
the thin brown testa encloses a colourless albumen, of which the
obtuser end is occupied by the small embryo.

The long pepper of the shops is greyish-white, and appears as if it
had been rolled in some earthy powder. When washed, the spikes acquire
their proper colour,—a deep reddish-brown. The drug has a burning
aromatic taste, and an agreeable but not powerful odour.

The foregoing description applies to the long pepper of English
commerce, which is now obtained chiefly from Java (see next page),
where _P. officinarum_ is the common species. In fact the fruits of
this latter, as presented to us by Mr. Binnendyk, of the Botanical
Garden, Buitenzorg, near Batavia, offer no characters by which we can
distinguish them from the article found in the London shops. Those of
_P. Betle_ L. var. γ. _densum_ are extremely similar, but we do not
know that they are collected for use.

=Microscopic Structure=—The structure of the individual fruits
resembles that of black pepper, exhibiting however some characteristic
differences. The epicarp has on the outside, tangentially-extended,
thick-walled, narrow cells, containing gum; the middle layer consists
of wider, thin-walled, obviously porous parenchyme containing starch
and drops of oil. In the outer and middle layers of the fruit numerous
large thick-walled cells are scattered, as in the external pericarp
of _Piper nigrum_; in long pepper, however, they do not form a close
circle. The inner pericarp is formed of a row of large, cubic or
elongated, radially-arranged cells, filled with volatile oil. A row
of smaller tangentially-extended cells separates these oil-cells
from the compact brown-red testa, which consists of lignified cells
like the inner layer of the testa of black pepper, but without the
thick-walled cells peculiar to the latter. The albumen of long pepper
is distinguished from that of black pepper by the absence of volatile
oil.

=Chemical Constituents=—The constituents of long pepper appear to
be the same as those of black pepper. We ascertained the presence of
piperin; 8 pounds of the drug were not sufficient to afford us an
appreciable quantity of the volatile oil. The resin and volatile oil
reside exclusively in the pericarp. Long pepper, according to Blyth
(1874), yields 8⅓ per cent. of ash.

=Commerce=—Long pepper is at present exported from Penang and
Singapore, whither it is brought chiefly from Java, and to a much
smaller extent from Rhio. The quantity exported from Singapore in
1871 amounted to 3,366 cwt., of which only 447 cwt. were shipped
to the United Kingdom, the remainder being sent chiefly to British
India.[2179] The export from Penang is from 2,000 to 3,000 peculs
annually. There is also a considerable export of long pepper from
Calcutta.

=Uses=—Long pepper is scarcely used as a medicine, black pepper having
been substituted in the few preparations in which it was formerly
ordered, but it is employed as a spice and in veterinary medicine.

The aromatic root of _Piper longum_, called in Sanskrit
_Pippali-mula_[2180] (whence the modern name _pipli-múl_), is a
favourite remedy of the Hindus and also known to the Persians and Arabs.


CUBEBÆ.

_Fructus vel Baccæ vel Piper Cubebæ_[2181]; _Cubebs_; F. _Cubèbes_; G.
_Cubeben_.

=Botanical Origin=—_Piper Cubeba_ Linn. f. (_Cubeba officinalis_ Miq.),
a climbing, woody, diœcious shrub, indigenous to Java, Southern Borneo
and Sumatra.[2182]

=History=—Cubebs have been introduced into medicine by the Arabian
physicians of the middle ages, who describe them as having the form,
colour, and properties of pepper. Masudi[2183] in the 10th century
stated them to be a production of Java. Edrisi,[2184] the geographer,
in A.D. 1153 enumerated them among the imports of Aden.

Among European writers, Constantinus Africanus of Salerno was
acquainted with this drug as early as the 11th century; and in the
beginning of the 13th its virtues were noticed in the writings of the
Abbess Hildegard in Germany, and even in those of Henrik Harpestreng in
Denmark.[2185]

Cubebs are mentioned as a production of Java (“_grant isle de Javva_”)
by Marco Polo; and by Odoric, an Italian friar, who visited the island
about forty years later. In the 13th century the drug was an article
of European trade, and would appear to have already been regularly
imported into London.[2186] Duty was levied upon them as _Cubebas
silvestres_ at Barcelona in 1271.[2187] They are mentioned about this
period as sold in the fairs of Champagne in France, the price being 4
_sous_ per lb.[2188] They were also sold in England: in accounts under
date 1284 they are enumerated with almonds, saffron, raisins, white
pepper, grains [of paradise], mace, galangal, and gingerbread, and
entered as costing 2_s._ per lb. In 1285—2_s._ 6_d._ to 3_s._ per lb.;
while in 1307, 1 lb. purchased for the King’s Wardrobe cost 9_s._[2189]

[2179] _Blue Book of the Straits Settlements for 1871._

[2180] Already in the Rāmāyana.

[2181] _Cubeba_ from the Arabic _Kabábah_.

[2182] Fig. in Bentley and Trimen’s _Med. Plants_, part 27 (1877).

[2183] _Les Prairies d’or_, i. 341.

[2184] _Géographie_, trad. par Jaubert, i. 51. 89.

[2185] Meyer, _Geschichte der Botanik_, iii. 537.

[2186] _Munimenta Gildhallæ Londoniensis; Liber albus_, i. (1859, State
papers) 230.

[2187] Capmany, _Memorias sobre la Marina, etc., de Barcelona_, i.
(Madrid, 1779) 44.

[2188] Bourquelot, _Etudes sur les foires de la Champagne, Mémoires
etc. de l’Institut_, v. (1865) 288.

[2189] Rogers, _Hist. of Agriculture and Prices in England_, i. 627-8,
ii. 544.—To get some idea of the relative value of commodities then and
now, multiply the ancient prices by 8.

From the journal of expenses of John, king of France, while in England
during 1359-60, it is evident that cubebs were in frequent use as a
spice. Among those who could command such luxuries, they were eaten
in powder with meat, or they were candied whole. A patent of pontage
granted in 1305 by Edward I., to aid in repairing and sustaining the
Bridge of London, and authorizing toll on various articles, mentions
among groceries and spices, cubebs as liable to impost.[2190] Cubebs
occur in the German lists of medicines of Frankfort and Nördlingen,
about 1450 and 1480;[2191] they are also mentioned in the _Confectbuch_
of Hans Folcz of Nuremberg, dating about 1480.[2192]

It cannot however be said that cubebs were a common spice, at all
comparable with pepper or ginger, or even in such frequent use as
grains of paradise or galangal. Garcia de Orta (1563) speaks of them as
but seldom used in Europe; yet they are named by Saladinus as necessary
to be kept in every _apotheca_.[2193] In a list of drugs to be sold
in the apothecaries’ shops of the city of Ulm, A.D. 1596, cubebs are
mentioned as _Fructus carpesiorum vel cubebarum_, the price for half
an ounce being quoted as 8 _kreuzers_, the same as that of opium,
best manna, and amber, while black and white pepper are priced at 2
_kreuzers_.[2194]

Although it was always well known that the cubebs were a product of
Java and that island is stated to have exported in 1775 as much as
10,000 lb. of this spice,[2195] its mother plant was made known only in
1781 by the younger Linnæus.

The action of cubebs on the urino-genital organs was known to the
old Arabian physicians. Yet modern writers on materia medica even at
the commencement of the present century, mentioned the drug simply
as an aromatic stimulant resembling pepper, but inferior to that
spice and rarely employed,[2196]—in fact it had so far fallen into
disuse that it was omitted from the London Pharmacopœia of 1809.
According to Crawfurd, its importation into Europe, which had long been
discontinued, recommenced in 1815, in consequence of its medicinal
virtues having been brought to the knowledge of the English medical
officers serving in Java, by their Hindu servants.[2197]

[2190] _Liber niger Scaccarii_, Lond. 1771, i. 478.—A translation may
be found in the _Chronicles of London Bridge_, 1827, 155.

[2191] _Archiv der Pharmacie_, 201 (1872) 441 and 211 (1877) 101.

[2192] Choulant, _Macer Floridus_, etc., Lips. 1832, 188.

[2193] _Compendium aromatariorum_, Bonon., 1488.

[2194] Richard, _Beiträge zur Geschichte der Apotheken_, 1825. 124.

[2195] Miquel, _Commentarii phytographici_, i. (Lugd. Bat., 1839).

[2196] In Duncan’s _Edinburgh New Dispensatory_, ed. 2. 1804, _Piper
Cubeba_ is very briefly described, but with no allusion to its
possessing any special medicinal properties. In the 6th edition of the
same work (1811) it was altogether omitted. See also Murray’s _System
of Mat. Med. and Pharm._ i. (1810) 266.

[2197] _Dictionary of the Indian Islands_, 1856. 117.—Mr. Crawfurd
himself communicated to the _Edinburgh Medical and Surgical Journal_ of
1818 (xiv. 32) a paper making known the “wonderful success” with which
cubebs had been used in gonorrhœa.

=Cultivation and Production=[2198]—Cubebs are cultivated in small
special plantations and also in coffee plantations, in the district
of Banjoemas in the south of Java. The fruits are bought by Chinese
who carry them to Batavia. They are likewise produced in Eastern Java
and about Bantam and Soebang in the north-west; and extensively in the
Lampong country in Sumatra. There has of late been a large distribution
of plants among the European coffee planters.

[2198] We are indebted for some particulars under this head to our
friends Mr. Binnendyk, of the Buitenzorg Botanical Garden near Batavia,
and Dr. De Vry.

The cultivation of cubebs is easy. In the coffee estates certain trees
are required for shade: against these _Piper Cubeba_ is planted, and
climbing to a height of 18 to 20 feet, forms a large bush.

=Description=—The cubebs of commerce consist of the dry globose fruits,
gathered when full-grown, but before they have arrived at maturity.
The fruit is about ⅕ of an inch in diameter, when very young sessile,
but subsequently elevated on a straight thin stalk, a little longer or
even twice as long as itself. By this stalk the fruit is attached in
considerable numbers (sometimes more than 50) to a common thickened
stalk or rachis, about 1½ inch long.

Commercial cubebs are spherical, sometimes depressed at the base,
very slightly pointed at the apex, strongly wrinkled by the shrinking
of the fleshy pericarp; they are of a greyish-brown or blackish hue,
frequently covered with an ashy-grey bloom. The stalk is the elongated
base of the fruit, and remains permanently attached. The common axis
or rachis, which is almost devoid of essential oil, is also frequently
mixed with the drug.

The skin of the fruit covers a hard, smooth brown shell containing the
seed, which latter when developed has a compressed spherical form, a
smooth surface, and adheres to the pericarp only at the base; its apex
either projects slightly or is pressed inwards. The albumen is solid,
whitish, oily, and encloses a small embryo below the apex. In the
cubebs of the shops, the seed is mostly undeveloped and shrunken, and
the pericarp nearly empty.

Cubebs have a strong, aromatic, persistent taste, with some bitterness
and acridity. Their smell is highly aromatic and by no means
disagreeable.

=Microscopic Structure=—This exhibits some peculiarities. The skin
of the fruit below the epidermis, is made up of small, cubic,
thick-walled cells, forming an interrupted row, and only half as large
as in black pepper. The broad middle layer consists of small cubic
thick-walled cells, forming an interrupted row, and only half as large
as in black pepper. The broad middle layer consists of small-celled
undeveloped tissue containing drops of oil, granules of starch, and
crystalline groups of cubebin, probably also fat. This middle layer
is interrupted by very large oil-cells, which frequently enclose
needle-shaped crystals of cubebin, united in concentric groups. The
much narrower inner layer consists of about four rows of somewhat
larger tangentially-extended soft cells, holding essential oil. Next to
these comes the light yellow brittle shell, formed of a densely packed
row of encrusted, radially-arranged, elongated thick-walled cells.
Lastly, the embryo is covered with a thin brown membrane, and exhibits
the structure and contents as that of _Piper nigrum_, excepting that in
_P. Cubeba_ the cells are rounder, and the crystals consist of cubebin
and not of piperin.

=Chemical Composition=—The most obvious constituent of cubebs is the
volatile oil, the proportion of which yielded by the drug varies from 4
to 13 per cent. The causes of this great variation may be found in the
constitution of the drug itself, as well as in the alterability of the
oil, and the fact that its prevailing constituents begin not to boil
below 264° C. It is, as shown in 1875 by Oglialoro, a mixture of an oil
C₁₀H₁₆, boiling at 158°-163°, which is present to a very small amount,
and two oils of the formula C₁₃H₂₄, boiling at 262°-265° C. One of the
latter deviates the plane of polarization strongly to the left, and
yields the crystallized compound C₁₅H₂₄ 2 HCl, melting at 118° C. The
other hydrocarbon is less lævogyrate and cannot be combined with HCl.

One part of oil of cubebs, diluted with about 20 parts of bisulphide of
carbon, assumes at first a greenish, and afterwards a blue coloration,
if one drop of a mixture of concentrated sulphuric and nitric acids
(equal weight of each acid) is shaken with the solution.

The oil distilled from old cubebs on cooling at length deposits large,
transparent, inodorous octohedra of _camphor of cubebs_, C₃₀H₄₈ + 2
OH₂, belonging to the rhombic system. They melt at 65° and may be
sublimed at 148°. We have not succeeded in obtaining them by keeping
the oil of fresh cubebs for two years in contact with water, to which a
little alcohol and nitric acid was added.

Another constituent of cubebs is _Cubebin_, crystals of which may
sometimes be seen in the pericarp even with a common lens. It was
discovered by Soubeiran and Capitaine in 1839; it is an inodorous
substance, crystallizing in small needles or scales, melting at 125°,
having a bitter taste in alcoholic solution; it dissolves freely in
boiling alcohol, but is mostly deposited upon cooling; it requires 30
parts of cold ether for solution, and is also abundantly soluble in
chloroform. We found this solution to be slightly lævogyre; it turns
red on addition of concentrated sulphuric acid. If the solution of
cubebin in chloroform is shaken with dry pentoxide of phosphorus, it
turns _blue_ and gradually becomes red by the influence of moisture.
Cubebin is nearly insoluble in cold, but slightly soluble in hot water.
Bernatzik (1866) obtained from cubebs 0·40 per cent. of cubebin,
Schmidt (1870) 2·5 per cent. The crystals, which are deposited in an
alcoholic or ethereal extract of cubebs, consist of cubebin in an
impure state. Cubebin is devoid of any remarkable therapeutic action.
Its composition, according to Weidel (1877) answers to the formula
C₁₀H₁₀O₃; by melting it with caustic potash, cubebin is resolved as
follows:—

    C₁₀H₁₀O₃ · 5 O = CO₂ ·  C₂H₄O₂   ·  C₆H₃(OH)₂COOH.
                           Acetic      Protocatechuic
                            Acid.           Acid.

The resin extracted from cubebs consists of an indifferent portion,
nearly 3 per cent., and of _Cubebic Acid_, amounting to about 1 per
cent. of the drug. Both are amorphous, and so, according to Schmidt,
are the salts of cubebic acid. Bernatzik however, found some of them,
as that of barium, to be crystallizable. Schulze (1873) prepared
cubebic acid from the crystallized sodium-salt, but was unable to get
it other than amorphous. The resins, the indifferent as well as the
acid, possess the therapeutic properties of the drug.

Schmidt further pointed out the presence in cubebs, of gum (8 per
cent.), fatty oil, and malates of magnesium and calcium.

=Commerce=—Cubebs were imported into Singapore in 1872 to the extent of
3062 cwt., of which amount 2348 cwt. were entered as from Netherlands
India. The drug was re-shipped during the same year to the amount of
2766 cwt., the quantity exported to the United Kingdom being 1180 cwt.,
to the United States of America 1244 cwt., and to British India 104
cwt.[2199] In the previous year, a larger quantity was shipped to India
than to Great Britain.

=Uses=—Cubebs are much employed in the treatment of gonorrhœa. The
drug is usually administered in powder; less frequently in the form of
ethereal or alcoholic extract, or essential oil.

Bernatzik and Schmidt, whose chemical and therapeutical experiments
have thrown much light on the subject, have shown that the efficacy
of cubebs being dependent on the indifferent resin and cubebic acid,
preparations which contain the utmost amount of these bodies and
exclude other constituents of the drug, are to be preferred. They would
reject the essential oil, as they find its administration devoid of
therapeutic effects.

The preparations which consequently are to be recommended, are the
berries deprived of their essential oil and constituents soluble in
water, and then dried and powdered; an alcoholic extract prepared from
the same, or the purified resins.

=Adulteration=—Cubebs are not much subject to adulteration, though it
is by no means rare that the imported drug contains an undue proportion
of the inert stalks (rachis)[2200] that require to be picked out before
the berries are ground. Dealers judge of cubebs by the oiliness and
strong characteristic smell of the berries when crushed. Those which
have a large proportion of the pale, smooth, ripe berries, which look
_dry_ when broken, are to be avoided.

We have occasionally found in the commercial drug a small, smooth
two-celled fruit, of the size, shape, and colour of cubebs, but wanting
the long pedicel. A slight examination suffices to recognize it as not
being cubebs. We have also met with some cubebs of larger size than the
ordinary sort, much shrivelled, with a stouter and flattened pedicel,
one and a half times to twice as long as the berry. The drug has an
agreeable odour different from that of common cubebs, and a very bitter
taste. From a comparison with herbarium specimens, we judge that it may
possibly be derived from _Piper crassipes_ Korthals (_Cubeba crassipes_
Miq.), a Sumatran species.

The fruits of _Piper Lowong_ Bl. (_Cubeba Lowong_ Miq.), a native of
Java, and those of _P. ribesioides_ Wall. (_Cubeba Wallichii_ Miq.) are
extremely cubeb-like.[2201] Those of _Piper caninum_ A. Dietr. (_Cubeba
canina_ Miq.), a plant of wide distribution throughout the Malay
Archipelago as far as Borneo, for a specimen of which we have to thank
Mr. Binnendyk of Buitenzorg, are smaller than true cubebs, and have
stalks only half the diameter of the berry.

[2199] _Straits Settlements Blue Book for 1872._ 294. 338.—There are
no statistics for showing the _total import_ of cubebs into the United
Kingdom.

[2200] They yielded to Schmidt 1·7 per cent. of oil and 3 per cent. of
resin.

[2201] Figured in Nees von Esenbeck, _Plantæ medicinales_, Düsseldorf,
i. (1828), tab. 22. A different figure is given by Miquel, _Comment.
phytogr._ (1839), tab. 3.

In the south of China the fruits of _Laurus Cubeba_ Lour. have been
frequently mistaken by Europeans for cubebs. The tree which affords
them is unknown to modern botanists; Meissner refers it doubtfully to
the genus _Tetranthera_.[2202]

Ashantee Pepper, African Cubebs, or West African Black Pepper.

This spice is the fruit of _Piper Clusii_ Cas. DC. (_Cubeba Clusii_
Miq.), a species of wide distribution in tropical Africa, most
abundantly occurring in the country of the Niamniam, about 4° to 5°
N. lat., and 28° to 29° E. long. Its splendid red fruit bunches are
spoken of with admiration by Schweinfurth,[2203] who states that
_Piper Clusii_ is one of the characteristic and most conspicuous
plants of those regions. The dried fruit is a round berry having a
general resemblance to common cubebs but somewhat smaller, less rugose,
attenuated into a slender pedicel once or twice as long as the berry
and usually curved. The berries are crowded around a common stalk or
rachis; they are of an ashy-grey tint, and have a hot taste and the
odour of pepper. According to Stenhouse, they contain piperin and not
cubebin.[2204]

The fruit of _Piper Clusii_ was known as early as 1364 to the
merchants of Rouen and Dieppe, who imported it from the Grain Coast,
now Liberia,[2205] under the name of pepper. The Portuguese likewise
exported it from Benin as far back as 1485, as _Pimienta de rabo_, i.e.
_tailed pepper_, and attempted in vain to sell it in Flanders.[2206]
Clusius received from London a specimen of this drug, of which he has
left a good figure in his _Exotica_.[2207] He says that its importation
was forbidden by the King of Portugal for fear it should depreciate the
pepper of India. The spice was also known to Gerarde and Parkinson;
in our times it has been afresh brought to notice by the late Dr.
Daniell.[2208] In tropical Western Africa it is used as a condiment,
and might easily be collected in large quantities, provided it should
prove a good substitute for pepper.[2209]

[2202] De Candolle, _Prod._ xv. sect. i. 199; Hanbury in _Pharm.
Journ._ iii. (1862) 205, with figure; also _Science Papers_, 247.

[2203] _Im Herzen Afrikas_, i. (1874) 507; ii. 399.

[2204] _Pharm. Journ._ xiv. (1855) 363.

[2205] Margry, _Les navigations françaises et la révolution maritime du
XIVᵉ au XVIᵉ siècle_, 1867. 26.

[2206] Giovanni di Barros, _l’Asia_, i. (Venet. 1561) 80.

[2207] Lib. i. c. 22, p. 184 (1605).

[2208] _Pharm. Journ._ xiv. (1855) 198.

[2209] One cask of it was offered for sale in London as “_Cubebs_,” 11
Feb. 1858.


HERBA MATICO.

_Matico._

=Botanical Origin=—_Piper angustifolium_[2210] Ruiz et Pavon (_Artanthe
elongata_ Miq.), a shrub growing in the moist woods of Bolivia, Peru,
Brazil, New Granada and Venezuela, also cultivated in some localities.
A slightly different, somewhat stouter form of the plant with leaves
7 to 8 inches long (var. α. _cordulatum_ Cas. DC.), occurs in the
Brazilian provinces of Bahia, Minas Geraes and Ceará, as well as in
Peru and the northern parts of South America.

[2210] Fig. in Bentley and Trimen’s _Med. Plants_, part 18 (1877).

=History=—The styptic properties of this plant are said to have been
discovered by a Spanish soldier named Matico,[2211] who having applied
some of the leaves to his wounds, observed that the bleeding was
thereby arrested; hence the plant came to be called _Yerba_ or _Palo
del Soldado_ (soldier’s herb or tree). The story is not very probable,
but it is current in many parts of South America, and its allusion is
not confined to the plant under notice.

The hæmostatic powers of matico, which are not noticed in the works
of Ruiz and Pavon, were first recognized in Europe by Jeffreys,[2212]
a physician of Liverpool, in 1839, but they had already attracted
attention in North America as early as 1827.

=Description=—Matico, as it arrives in commerce, consists of a
compressed, coherent, brittle mass of leaves and stems, of a light
green hue and pleasant herby odour. More closely examined, it is seen
to be made up of jointed stems bearing lanceolate, acuminate leaves,
cordate and unequal at the base, and having very short stalks. The
leaves are rather thick, with their whole upper surface traversed by
a system of minute sunk veins, which divide it into squares and give
it a tessellated appearance. On the under side, these squares form
a corresponding series of depressions which are clothed with shaggy
hairs. The leaves attain a length of about 6 inches by 1½ inches broad.
The flower and fruit spikes which are often 4 to 5 inches long, are
slender and cylindrical with the flowers or fruits densely packed. The
leaves of matico have a bitterish aromatic taste; their tissue shows
numerous cells, filled with essential oil.[2213]

=Chemical Composition=—The leaves yield on an average 27 per
cent.[2214] of essential oil, which we find slightly[2215] dextrogyre;
a large proportion of it distills at 180° to 200° C., the remainder
becoming thickish. Both portions are lighter than water; but another
specimen of the oil of matico which we had kept for some years, sinks
in water. We have observed that in winter the oil deposits remarkable
crystals of a camphor, more than half an inch in length, fusible at
103° C.; they belong to the hexagonal system, and have the odour and
taste of the oil from which they separate.

Matico further affords, according to Marcotte (1864),[2216] a
crystallizable acid, named _Artanthic Acid_, besides some tannin. The
latter is made evident by the dark brown colour which the infusion
assumes on addition of ferric chloride. The leaves likewise contain
resin, but as shown by Stell in 1858, neither piperin, cubebin, nor any
analogous principle such as the so-called _Maticin_ formerly supposed
to exist in them.

[2211] Matico is the diminutive of _Mateo_, the Spanish for _Matthew_.

[2212] _Remarks on the efficacy of Matico as a styptic and astringent_,
3rd ed., Lond. 1845.

[2213] Microscopic examination of the leaves, Pocklington, _Pharm.
Journ._ v. (1874) 301.

[2214] As Messrs. Schimmel & Co., Leipzig, kindly informed me.—F. A. F..

[2215] Deviating only 0.7° in a column 50 mm. long.

[2216] Guibourt (et Planchon), _Hist. des Drogues_, ii. (1869) 278.—We
are not acquainted with “artanthic acid.”

=Commerce=—The drug is imported in bales and serons by way of Panama.
Among the exports of the Peruvian port of Arica in 1877, we noticed 195
quintales (19,773 lb) of Matico.

=Uses=—Matico leaves, previously softened in water, or in a state of
powder, are sometimes employed to arrest the bleeding of a wound. The
infusion is taken for the cure of internal hæmorrhage.

=Substitutes=—Several plants have at times been brought into the market
under the name of _matico_. One of these is _Piper aduncum_ L.[2217]
(_Artanthe adunca_ Miq.), of which a quantity was imported into London
from Central America in 1863, and first recognized by Bentley (1864).
In colour, odour, and shape of leaf it nearly agrees with ordinary
matico; but differs in that the leaves are marked beneath by much more
prominent ascending parallel nerves, the spaces between which are
not rugose but comparatively smooth and nearly glabrous. In chemical
characters, the leaves of _P. aduncum_ appear to accord with those of
_P. angustifolium_.

_Piper aduncum_ is a plant of wide distribution throughout Tropical
America. Under the name of _Nhandi_ or _Piper longum_ it was mentioned
by Piso in 1648[2218] on account of the stimulant action of its leaves
and roots,—a property which causes it to be still used in Brazil, where
however no particular styptic virtues seem to be ascribed to it.[2219]
The fruits are there employed in the place of cubebs. Sloane’s
figure[2220] of “Piper longum, arbor folio latissimo” also shows _Piper
aduncum_.

According to Triana, _Piper lanceæfolium_ HBK. (_Artanthe_ Miq.), and
another species not recognized, yield matico in New Granada.[2221]
_Waltheria glomerata_ Presl (_Sterculiaceæ_) is called _Palo del
Soldado_ at Panama and its leaves are used as a vulnerary.[2222] In
Riobamba and Quito, _Eupatorium glutinosum_ Lamarck, is also called
Chusalonga or _Matico_.[2223]

[2217] For a good figure, see Jacquin, _Icones_ II. (1781-1793) tab.
210.

[2218] _De Medicinâ Brasiliensi_, lib. 4. c. 57.

[2219] Langgaard, _Diccionario de Medicina domestica e popular_, Rio de
Janeiro, ii. (1865) 44.

[2220] _Voyage to Jamaica_ I. (1707) 135, and tab. 88.

[2221] Exposition de 1867—Catalogue de M. José Triana, p. 14.

[2222] Seemann, _Botany of the Herald_, 1852-57. 85.

[2223] Bentham, _Plantæ Hartwegianæ_, Lon. 1839. 198.




ARISTOLOCHIACEÆ.


RADIX SERPENTARIÆ.

_Radix Serpentariæ Virginianæ_; _Virginian Snake-root_, _Serpentary
Root_; F. _Serpentaire de Virginie_; G. _Schlangenwurzel_.

=Botanical Origin=—_Aristolochia Serpentaria_ L., a perennial herb,
commonly under a foot high, with simple or slightly branched, flexuose
stems, producing small, solitary, dull purple flowers, close to the
ground. It grows in shady woods in the United States, from Missouri and
Indiana to Florida and Virginia,—abundantly in the Alleghanies and in
the Cumberland Mountains, less frequently in New York, Michigan and the
other Northern States. The plant varies exceedingly in the shape of its
leaves.

=History=—The botanists of the 16th century, being fond of
appellations alluding to the animal kingdom, gave the names of
_Serpentaria_ or Colubrina, _i.e._ snake-root, to the rhizome of
_Polygonum Bistorta_ L. In America it was not the appearance, but
the application of the drug under notice to which it owes the name
snake-root.

The earliest account of _Virginian_ snake-root is that of Thomas
Johnson, an apothecary of London who published an edition of Gerarde’s
Herbal in 1636. It is evident however that Johnson confounded a species
of _Aristolochia_ from Crete with what he calls “that snake-weed that
was brought from Virginia and grew with Mr. John Tradescant at South
Lambeth, anno 1632.” It was very briefly noticed by Cornuti in his
_Canadensium Plantarum Historia_ (1635), and in a much more intelligent
manner by Parkinson in 1640. These authors, as well as Dale (1693) and
Geoffroy (1741), extol the virtues of the root as a remedy for the bite
of the rattlesnake, or of a rabid dog. Serpentary was introduced into
the London Pharmacopœia in 1650.

=Description=—The snake-root of commerce includes the rhizome, which
is knotty, contorted, scarcely 1 inch in length by ⅛ of an inch in
thickness, bearing on its upper side the short bases of the stems of
previous years, and throwing off from the under, numerous, slender,
matted, branching roots, 2 to 4 inches long. The rhizome is often still
attached to portions of the weak, herbaceous stem, which sometimes
bears the fruit,—more rarely flowers and leaves. The drug has a dull
brown hue, an aromatic odour resembling valerian but less unpleasant,
and a bitterish aromatic taste, calling to mind camphor, valerian and
turpentine.

=Microscopic Structure=—In the rhizome, the outer layer of the bark
consists of a single row of cuboid cells; the middle cortical portion
(_mesophlœum_) of about six layers of larger cells. In the liber, which
is built up of numerous layers of smaller cells, those belonging to
the medullary rays are nearly cuboid with distinctly porous walls,
those of the liber bundles being smaller and arranged in a somewhat
crescent-shaped manner. Groups of short, reticulated or punctuated
vessels alternate in the woody rays with long, porous, ligneous cells;
those close to the pith having thick walls. The largest cells of all
are those composing the pith; the latter, seen in transverse section,
occupies not the very centre of the rootstock, but is found nearer to
its upper side. The rootlets exhibit a central fibro-vascular bundle,
surrounded by a nucleus-sheath. In the mesophlœum both of the rootstock
and the rootlets, there occur a few cells containing a yellow essential
oil. The other cells are loaded with starch.

=Chemical Composition=—Essential oil exists in the drug to the extent
of about ½ per cent.; and resin in nearly the same proportion. The
outer cortical layer, as well as the zone of the nucleus-sheath,
contains a little tannin, and a watery infusion of the drug is coloured
greenish by perchloride of iron. Neutral acetate of lead precipitates
some mucilage as well as the bitter principle, which latter may also be
obtained by means of tannic acid. It is an amorphous, bitter substance,
which deserves further investigation. By an alkaline solution of
tartrate of copper the presence in serpentary of sugar is made evident.

=Commerce=—Virginian snake-root is imported from New York and Boston,
in bales, casks or bags.

=Uses=—The drug is employed in the form of an infusion or tincture as
a stimulating tonic and diaphoretic; it is more often prescribed in
combination with cinchona bark than by itself. Its ancient reputation
for the cure of snake-bites is now disregarded.

=Adulteration and Substitution=—Virginian snake-root is said to be
sometimes adulterated with the root of _Spigelia marilandica_ L.,
which has neither its smell nor taste (see p. 433); or with that of
_Cypripedium pubescens_ L., which it scarcely at all resembles. It is
not uncommon to find here and there in the serpentary of commerce, a
root of _Panax quinquefolium_ L. accidentally collected, but never
added for the purpose of adulteration.

The root of _Aristolochia reticulata_ Nutt., a plant of Louisiana and
Arkansas, has been brought into commerce in considerable quantity
as _Texan_ or _Red River Snake-root_.[2224] We are indebted for an
authentic specimen from the Cherokee country to Mr. Merrell, a large
dealer in herbs at St. Louis, Missouri, who states that all the
serpentary grown south-west of the Rocky Mountains is the produce of
that species. The late Prof. Parrish of Philadelphia was kind enough
to supply us with specimens of the same drug, as well as with reliable
samples of true _Virginian_ or _Middle States Snake-root_.

The Texan snake-root is somewhat thicker and less matted than that
derived from _A. Serpentaria_, but has the odour and taste of the
latter; some say it is less aromatic. The plant, portions of which
are often present, may be easily distinguished by its leaves being
_coriaceous_, _sessile_ and _strongly reticulated_ on their under
surface.

[2224] Wiegand in _American Journ. of Pharm._ x. (1845) 10; also
_Proceedings of the Am. Pharm. Association_, xxi. (1873) 441.




CUPULIFERÆ.


CORTEX QUERCUS.

_Oak Bark_; F. _Ecorce de Chêne_; G. _Eichenrinde_.

=Botanical Origin=—_Quercus Robur_ L., a tree, native of almost the
whole of Europe, from Portugal and the Greek Peninsula as far north as
58° N. lat. in Scotland, 62° in Norway, and 56° in the Ural Mountains.

There are two remarkable forms of this tree which are regarded by
many botanists as distinct species, but which are classed by De
Candolle[2225] as sub-species.

Sub-species I. _pedunculata_—with leaves sessile or shortly stalked,
and acorns borne on a long peduncle, and acorns either sessile or
growing on a short peduncle.

Sub-species II. _sessiliflora_—with leafstalks more or less elongated.

Both forms occur in Britain. The first is the common oak of the greater
part of England and the lowlands of Scotland. The second is frequently
scattered in woods in which the first variety prevails, but it rarely
constitutes the mass of the oak woods in the south of England. In North
Wales however, in the hilly parts of the north of England, and in
Scotland, it is the commoner of the two forms (Bentham).

[2225] _Prodromus_, xvi. (1864) sect. 2. fasc. 1.

=History=—The astringent properties of all parts of the oak[2226] were
well known to Dioscorides, who recommends a decoction of the inner
bark in colic, dysentery and spitting of blood. Yet oak bark seems at
no time to have been held in great esteem as a medicine, probably on
account of its commonness; and it is now almost superseded by other
astringents. For tanning leather it has always been largely employed.

[2226] Probably not _Q. Robur_ L.

=Description=—For medicinal use the bark of the younger stems or
branches is collected in the early spring. It varies somewhat in
appearance according to the age of the wood from which it has been
taken: that usually supplied to English druggists is in channelled
pieces of variable length and a tenth of an inch or less in thickness,
smooth, of a shining silvery grey, variegated with brown, dotted
over with little scars. The inner surface is light rusty-brown,
longitudinally striated. The fracture is tough and fibrous. A
transverse section shows a thin, greenish cork-layer, within which
is the brown parenchyme, marked with numerous rows of translucent
colourless spots. The smell of dry oak bark is very faint; but when
the bark is moistened the odour of tan becomes evident. The taste is
astringent and in old barks slightly bitter.

=Microscopic Structure=—The outer layer of young oak bark consists of
small flat cork-cells; the middle layer of larger thick-walled cells
slightly extended in a tangential direction, and containing brown
grains and chlorophyll. This tissue passes gradually into the softer
narrower parenchyme of the inner bark, which is irregularly traversed
by narrow medullary rays. It exhibits moreover a ring, but slightly
interrupted, of thick-walled cells (sclerenchyme) and isolated shining
bundles of liber-fibres.

Groups of crystals of calcium oxalate are frequent in the middle and
inner bark, but the chief constituents of the cells are brown granules
of colouring matter and tannin. As the thickness of the bark increases
the liber is pushed more to the outside, the middle cortical layer
being partly thrown off by secondary cork-formation (rhytidoma, see pp.
354 and 538). Hence the younger barks, which alone are medicinal, are
widely different from the older in structure and appearance.

=Chemical Composition=—The most interesting constituent is a peculiar
kind of tannin. Stenhouse pointed out in 1843 that the tannic acid of
oak bark is not identical with that of nutgalls; and such many years
afterwards was proved to be the case.

The first-named substance, now called _Querci-tannic Acid_, yields
by destructive distillation pyrocatechin, and according to Johanson
(1875) very little pyrogallol. By boiling it with dilute sulphuric
acid querci-tannic acid is split up into a red derivative and sugar.
A solution of gelatine is precipitated by querci-tannic acid as well
as by gallo-tannic acid; yet the compound formed with the latter is
very liable to putrefaction, whereas the tannin of oak bark, which is
accompanied by a large amount of extractive matter, furnishes a stable
compound, and is capable of forming good leather.

As querci-tannic acid has not yet been isolated in a pure state, the
exact estimation of the strength of the tanning principle in oak
bark has not been accomplished, although it is important from an
economic as well as from a scientific point of view. The method of
Neubauer (1873) depends upon the amount of permanganate of potassium
decomposable by the extract of a given weight of oak bark. Neubauer
found in the bark of young stems, as grown for tanning purposes, from 7
to 10 per cent. of querci-tannic acid, soluble in cold water.

Braconnot (1849) extracted from the seeds of the oaks under notice
a crystallized sugar, which was shown in 1851 by Dessaignes to be
a peculiar substance, which he termed _Quercite_. Prunier proved
(1877-1878) that it agrees with the formula C₆H₇(OH)₅ + 4 OH₂, and is
closely allied to kinic acid, C₆H₇(OH)₄COOH (see page 363). Quercite
gives off water at 100°, melts at 225° C., and again losing water
yields a crystallized anhydride. In the oak bark extremely small
quantities of quercite appear also to be present, as pointed out by
Johanson.

A colourless, crystallizable, bitter substance, soluble in water, but
not in absolute alcohol or ether, was extracted from oak bark in 1843
by Gerber, and named _Quercin_. It requires further examination: Eckert
(1864) could not detect its existence in young oak bark.

=Uses=—Occasionally employed as an astringent, chiefly for external
application.


GALLÆ HALEPENSES.

    _Gallæ Turcicæ_; _Galls_, _Nutgalls_,
       _Oak Galls_, _Aleppo_ or _Turkey Galls_;
        F. _Noix de Galle_, _Galle d’Alep_;
        G. _Levantische oder Aleppische Gallen_,
        _Galläpfel_.

=Botanical Origin=—_Quercus lusitanica_ Webb, var. _infectoria_ (_Q.
infectoria_ Oliv.),[2227] a shrub or rarely a tree, found in Greece,
Asia Minor, Cyprus and Syria. It is probable that other varieties of
this oak, as well as allied species, contribute to furnish the Aleppo
galls of commerce.

=History=—Oak galls are named by Theophrastus, and were well known to
other ancient writers. Alexander Trallianus prescribed them as a remedy
in diarrhœa.[2228]

The earliest accurate descriptions and figures of the oak and the
insect producing the galls are due to Olivier.[2229] Pliny[2230]
mentions the interesting fact that paper saturated with an infusion
of galls may be used as a test for discovering sulphate of iron, when
added as an adulteration to the more costly verdigris: this, according
to Kopp, is the earliest instance of the scientific application of a
chemical reaction.[2231] For tanning and dyeing, galls have been used
from the earliest times, during the middle ages however they were not
precisely an article of great importance, being then, no doubt, for a
large part replaced by sumach.

Nutgalls have long been an object of commerce between Western Asia and
China. Barbosa in his _Description of the East Indies_[2232] written
in 1514 calls them _Magican_,[2233] and says they are brought from the
Levant to Cambay by way of Mekka, and that they are worth a great deal
in China and Java. From the statements of Porter Smith[2234] we learn
that they are still prized by the Chinese.

[2227] De Candolle, _Prodromus_, xvi. sect. 2. fasc. i. 17.

[2228] Puschmann’s edition, quoted in the Appendix, i. 237.

[2229] _Voyage dans l’Empire Othoman_, ii. (1801), pl. 14-15.

[2230] Lib. 34. c. 26.

[2231] _Geschichte der Chemie_, ii. (1844) 51.

[2232] Published by the Hakluyt Society, Lond. 1866. 191.

[2233] Nearly the same name is still used in the Tamil, Telugu,
Malayalim and Canarese languages.

[2234] _Mat. Med. and Nat. Hist. of China_, 1871. 100.

=Formation=—Many plants are punctured by insects for the sake of
depositing their eggs, which operation gives rise to those excrescences
which bear the general name of _gall_.[2235]

Oaks are specially liable to be visited for this purpose by insects
of the order _Hymenoptera_ and the genus _Cynips_, one species of
which, _Cynips Gallæ tinctoriæ_ Olivier (_Diplolepis Gallæ tinctoriæ_
Latreille), occasions the galls under notice.

The female of this little creature is furnished with a delicate borer
or ovipositor, which she is able to protrude from the extremity of the
abdomen; by means of it she pierces the tender shoot of the oak, and
deposits therein one or more eggs. This minute operation occasions an
abnormal affluence to the spot of the juices of the plant, the result
of which is the growth of an excrescence often of great magnitude, in
the centre of which (but not as it appears until the gall has become
full-grown) the larva is hatched and undergoes its transformations.

When the larva has assumed its final development and become a winged
insect, which requires a period of five to six months, the latter
bores itself a cylindrical passage from the centre of the gall to its
surface, and escapes.

In the best kind of gall found in commerce, this stage has not yet
arrived, the gall having been gathered while the insect is still in
the larval state. In splitting a number of galls, it is not difficult
to find specimens in all stages, from those containing the scarcely
distinguishable remains of the minute larva, to those which show the
perfect insect to have perished when in the very act of escaping from
its prison.

=Description=—Aleppo galls[2236] are spherical, and have a diameter of
⁴/₁₀ to ⁸/₁₀ of an inch. They have a smooth and rather shining surface,
marked in the upper half of the gall by small pointed knobs and ridges,
arranged very irregularly and wide apart; the lower half is more
frequently smooth. The aperture by which the insect escapes is always
near the middle. When not perforated, the galls are of a dark olive
green, and comparatively heavy; but after the fly has bored its way
out, they become of a yellowish-brown hue, and lighter in weight. Hence
the distinction in commerce of _Blue_ or _Green Galls_, and _White
Galls_.

[2235] French writers, as Moquin-Tandon, distinguish the thick-walled
galls of _Cynips_ from the thin, capsular galls formed by _Aphis_,
terming the former _galles_ and the latter _coques_ (shells).

[2236] There are many other varieties of oak gall, for descriptions
of some of which, see Guibourt, _Hist. des Drogues_, ii. (1869)
292; and for information on the various gall-insects of the family
_Cynipsidæ_ and the excrescences they produce, consult a paper by Abl
in Wittstein’s _Vierteljahresschrift für prakt_. _Pharm._ vi. (1857)
343-361.

Aleppo galls are hard and brittle, splitting under the hammer;
they have an acidulous, very astringent taste followed by a slight
sweetness, but have no marked odour. Their fractured surface is
sometimes close-grained, with a waxy or resinous lustre; sometimes
(especially towards the kernel-like centre) loosely granular, or
sometimes again it exhibits a crystalline-looking radiated structure or
is full of clefts. The colour of the interior varies from pale brown
to a deep greenish yellow. The central cavity, sometimes nearly ¼ of
an inch in diameter, which served as a dwelling for the insect, is
lined with a thin hard shell. If the insect has perished while still
very young, the central cavity and the aperture contain a mass of loose
starchy cellular tissue, or its pulverulent remains: if the insect has
not been developed at all, the centre of the gall is entirely composed
of this tissue.

=Microscopic Structure=—The cellular tissue of the gall is formed in
the middle layer of large spherical cells with rather thick porous
walls, becoming considerably smaller towards the circumference. The
outermost rows are built up of cells having but a very small lumen
and comparatively thick walls, so that they form a sort of rind. Here
and there throughout the entire tissue, there occur isolated bundles
of vessels which pass through the stalk into the gall. Towards the
kernel, the parenchyme gradually passes into radially-extended,
wider, thin-walled cells, the walls of which are marked with spiral
striæ. The hard shell of the chamber[2237] is composed of larger,
radially-extended, thick-walled cells, with beautifully stratified
porous walls. On the inner side of this shell there are found, after
the escape of the insect, the remains of the starchy tissue already
mentioned, which originally filled the chamber and had been consumed by
the insect as nourishment.

[2237] _Couche protectrice_ of Lacaze-Duthiers—_Recherches pour servir
à l’histoire des galles_.—_Ann. des Sciences Nat._, Bot. xix. (1853)
273-354.

The parenchyme-cells outside the shell contain chlorophyll and tannin;
the latter is in transparent, colourless, sharp-edged masses, insoluble
in benzol, but dissolving slowly in water, quickly in alcohol. Thin
slices soaked in glycerin appear after some time covered with beautiful
crystals of gallic acid. The thick-walled cells (stone-cells) and the
neighbouring striated cells, are rich in octahedra of calcium oxalate.
The tissue of the gall situated within the shell of thick-walled cells
contains starch in large, compressed, mostly spherical granules; also
isolated masses of brown resin. Besides these, there appears to be in
this part of the tissue an albuminoid compound.

=Chemical Composition=—The rough taste of galls is due to their chief
constituent, _Tannic_ or _Gallo-tannic Acid_, C₁₄H₁₀O₉, or

    C₆H₂(OH)₂COOH}
                 }O
      C₆H₂(OH)₂CO}

the type of a numerous family of substances to which vegetables owe
their astringent properties. Tannic matter was long supposed to be
of one kind, namely that found in the oak gall, but the researches
of later years have proved the tannin of different plants to possess
distinctive characters: hence the term _gallo-tannic_ acid to
distinguish that of galls, from which it is principally derived. It
was however shown by Stenhouse as far back as the year 1843, again in
1861, as well as by still more recent unpublished experiments, that the
tannic acid found in Sicilian sumach, the leaves of _Rhus Coriaria_
L., is identical with that of oak galls. Löwe in 1873 came to the same
conclusion. The best oak galls yield of this acid, from 60 to 70 per
cent.

_Gallic Acid_ is also contained in galls ready-formed to the extent of
about 3 per cent. Free sugar, resin, protein-substances, have also been
found. Neither gum nor dextrin is present.

=Commerce=—The introduction into dyeing of new chemical substances,
and the increased employment of sumach and myrobalans, have caused the
trade in nutgalls to decline considerably during the last few years.
The province of Aleppo which used to export annually 10,000 to 12,000
quintals, exported in 1871 only 3000 quintals.[2238] A staple market
for the galls which are collected in the mountains of Kurdistan is
Diarbekir, whence they are sent to Trebizond for shipment. Galls are
also shipped in some quantity at Bussorah, Bagdad, Bushire, and Smyrna.

There were imported into the United Kingdom from ports of Turkey and
Persia during 1872, 6349 cwt. of galls, valued at £18,581.

=Uses=—Oak galls in their crude state are seldom used in medicine
unless it be externally; but the tannic and gallic acids extracted from
them are often administered.

Other kinds of Gall.

_Chinese or Japanese Galls_—The only kind of galls, besides those of
the oak, which are of commercial importance. They are described at page
167.

_Pistacia Galls_—The genus _Pistacia_, which belongs to the same order
as _Rhus_, is very liable to the attacks of _Aphis_, which produce
upon its leaves and branches excrescences of exactly the same nature
as Chinese galls. In the south of Europe, horn-like follicles, often
several inches long,[2239] are frequently met with on the branches
of _Pistacia Terebinthus_ (page 165). These _Gallæ vel Folliculi
Pistacinæ_, in Italian _Carobbe di Giudea_, were formerly used in
medicine and in dyeing.[2240] They were noticed in 1555 by Belon, but
already well known as early as the time of Theophrastus.

Another much smaller gall of different shape is formed (by the same
insect?) on the ribs of the leaves of _Pistacia Terebinthus_; _P.
Lentiscus_ (page 161) affords also a similar small excrescence.

Again, another growth of the same character constitutes the small
and very astringent galls known in the Indian bazaars by the names
of _Bazghanj_ and _Gule-pistah_, the latter signifying _flower of
pistachio_; they have been termed in Europe _Bokhara Galls_. They were
imported by sea into Bombay in the year 1872-73, to the extent of 184
cwt., chiefly from Sind;[2241] and are also carried into North-western
India by way of Peshawar and by the Bolan Pass. Occasionally a package
finds its way into a London drug sale.

_Tamarisk Galls_—These are roundish knotty excrescences of the size
of a pea up to ½ an inch in diameter, found in North-western India on
the branches of _Tamarix orientalis_ L., a large, quick-growing tree,
common on saline soils. The galls are used in India in the place of
oak galls, and are mentioned as “non-officinal” in the _Pharmacopœia
of India_, 1867. We are not aware that they have been the subject of
any particular chemical research; their microscopic structure has been
investigated by Vogl.[2242]

[2238] Consul Skene—_Reports of H. M. Consuls_, No. 1. 1872. 270.

[2239] For a figure, see _Pharm. Journ._ iii. (1844) 387. For the
structure see Marchand, in the paper quoted at page 166, note 4, plate
iii.

[2240] Analysis by Martius may be found in Liebig’s _Ann. d. Pharm._
xxi. (1837) 179.

[2241] From the returns quoted at page 333, note 3.

[2242] _Zeitschrift des Oesterreichischen Apothekervereines_, 1877. 14.




SANTALACEÆ.


LIGNUM SANTALI.

_Lignum Santalinum album vel citrinum_; _Sandal-wood_; F. _Bois de
Santal citrin_; G. _Weisses oder Gelbes Sandelholz_.

=Botanical Origin=—_Santalum album_[2243] L., a small tree, 20 to 30
feet high, with a trunk 18 to 35 inches in girth, a native of the
mountainous parts of the Indian peninsula, but especially of Mysore
and parts of Coimbatore and North Canara, in the Madras Presidency;
it grows in dry and open places, often in hedge-rows, not in forests.
The same tree is also found in the islands of the Eastern Archipelago,
notably of Sumba (otherwise called Chandane or Sandal-wood Island), and
Timur.

In later times, sandal-wood has been extensively collected in the
Hawaiian or Sandwich Islands, where its existence was first pointed
out about the year 1778, from _Santalum Freycinetianum_ Gaud. and _S.
pyrularium_ A. Gray;[2244] in the Viti or Fiji Islands from _S. Yasi_
Seem.; in New Caledonia from _S. austro-caledonicum_, Vieill;[2245] and
in Western Australia from _Fusanus spicatus_ Br. (_Santalum spicatum_
DC., _S. cygnorum_ Miq.).[2246] The mother plants of _Japanese_ and
_West Indian_ sandal-wood are not known to us.

In India the sandal-wood tree is protected by Government, and is the
source of a profitable commerce. In other countries it has been left to
itself, and has usually been extirpated, at least from all accessible
places, within a few years of its discovery.

=History=—Sandal-wood, the Sanskrit name for which, _Chandana_,
has passed into many of the languages of India, is mentioned in
the _Nirukta_ or writings of Yaska, the oldest Vedic commentary
extant, written not later than the 5th century B.C. The wood is also
referred to in the ancient Sanskrit epic poems, the _Rāmāyana_ and
_Mahabharata_, parts of which may be of nearly as early date.

The author of the _Periplus of the Erythrean Sea_, written about the
middle of the 1st century, enumerates sandal-wood (Ξύλα σαγαλίνα) among
the Indian commodities imported into Omana in the Persian Gulf.[2247]

The Τζανδάνα mentioned towards the middle of the 6th century by Cosmas
Indicopleustes,[2248] as brought to Taprobane (Ceylon) from China and
other emporia, was probably the wood under consideration. In Ceylon its
essential oil was used as early as the 9th century in embalming the
corpses of the princes.

[2243] Fig. in Bentley and Trimen’s _Medic. Plants_, part 18 (1877).

[2244] Seemann, _Flora Vitiensis_, 1865-73. 210-215.

[2245] The natural woods having been nearly exhausted, the tree is
now under culture in the island. _Catalogue des produits des colonies
françaises, Exposition de 1878_, p. 332; they state there that the
island of Nossi-bé, on the north-western coast of Madagascar, also
supplies some sandal-wood.

[2246] Whether _Santalum lanceolatum_ Br., a tree found throughout N.
and E. Australia, and called _sandal-wood_ by the colonists, is an
object of trade, we know not.

[2247] Vincent, _Commerce and Navigation of the Ancients_, ii. (1807)
378.

[2248] Migne, _Patrologiæ Cursus_, series Græca, tom. 88. 446.

Sandal-wood is named by Masudi[2249] as one of the costly aromatics
of the Eastern Archipelago. In India it was used in the most sacred
buildings, of which a memorable example still exists in the famous
gates of Somnath, supposed to be 1000 years old.[2250]

In the 11th century sandal-wood was found among the treasures of the
Egyptian khalifs, as stated in our article on camphor at page 511.

Among European writers, Constantinus Africanus, who flourished at
Salerno in the 11th century, was one of the earliest to mention
Sandalum.[2251] Ebn Serabi, called Serapion the Younger, who lived
about the same period, was acquainted with _white_, _yellow_, and
_red_ sandal-wood.[2252] All three kinds of sandal-wood also occur in
a list of drugs[2253] in use at Frankfort, _circa_ A.D. 1450; and in
the _Compendium Aromatariorum_ of Saladinus, published in 1488, we find
mentioned as proper to be kept by the Italian apothecary,—“_Sandali
trium generum, scilicet albi, rubii et citrini_.”

Whether the _red_ sandal here coupled with _white_ and _yellow_ was
the inodorous wood of _Pterocarpus santalinus_, now called _Lignum
santalinum rubrum_ or _Red Sanders_ (see p. 199), is extremely
doubtful. It may have meant real sandal wood, of which three shades,
designated _white_, _red_, and _yellow_, are still recognized by the
Indian traders.[2254]

On the other hand, we learn from Barbosa[2255] that about 1511 _white_
and _yellow_ sandal-wood were worth at Calicut on the Malabar Coast
from eight to ten times as much as the _red_, which would show that in
his day the red was not a mere variety of the other two, but something
far cheaper, like the Red Sanders Wood of modern commerce.

In 1635 the subsidy levied on sandal-wood imported into England was
1_s._ per lb. on the _white_, and 2_s._ per lb. on the _yellow_.[2256]

[2249] I. 222 in the work quoted in the Appendix.

[2250] They are 11 feet high and 9 feet wide, and richly carved out
of sandal-wood; they were constructed for the temple of Somnath in
Guzerat, once esteemed the holiest temple in India. On its destruction
in A.D. 1025, the gates were carried off to Ghuzni in Afghanistan,
where they remained until the capture of that city by the English in
1842, when they were taken back to India. They are now preserved in the
citadel of Agra. For a representation of the gates, see _Archæeologia_,
xxx. (1844) pl. 14.

[2251] Opera, Basil. 1536-39, _Lib. de Gradibus_, 369.

[2252] _Liber Serapionis aggregatus in medicinis simplicibus_, 1473.

[2253] Flückiger, _Die Frankfurter Liste_, Halle, 1873. 11.

[2254] Thus Milburn in his _Oriental Commerce_ (1813) says—“ ... the
deeper the colour, the higher is the perfume; and hence the merchants
sometimes divide sandal into _red_, _yellow_, and _white_, but these
are all different shades of the same colour, and do not arise from any
difference in the species of the tree.”—(i. 291.)

[2255] Ramusio, _Navigationi et Viaggi_, etc., Venet. 1554. fol. 357
b., _Libro di Odoardo Barbosa Portoghese_.

[2256] _The Rates of Marchandizes_, Lond. 1635.

The first figure and satisfactory description of _Santalum album_ occur
in the _Herbarium Amboinense_ of Rumphius (ii. tab. 11).

=Production=—The dry tracts producing this valuable wood occupy patches
of a strip of country lying chiefly in Mysore and Coimbatore, about
250 miles long, north and north-west of the Neilgherry Hills, and
having Coorg and Canara between it and the Indian Ocean; also a piece
of country further eastward in the districts of Salem and North Arcot,
where the tree grows from the sea-level up to an elevation of 3000
feet. In Mysore, where sandal-wood is most extensively produced, the
trees all belong to Government, and can only be felled by the proper
officers. This privilege was conferred on the East India Company by a
treaty with Hyder Ali, made 8 August 1770, and the monopoly has been
maintained to the present day. The Mysore animal exports of sandal wood
are about 700 tons, valued at £27,000.[2257] They are shipped from
Mangalore.

A similar monopoly existed in the Madras Presidency until a few years
ago, when it was abandoned. But sandal-wood is still a source of
revenue to the Madras Government, which by the systematic management of
the Forest Department has of late years been regularly increasing. The
quantity of sandal-wood felled in the Reserved Forests during the year
1872-3 was returned as 15,329 maunds (547½ tons).[2258]

The sandal-wood tree, which is indigenous to the regions just
mentioned, used to be reproduced by seeds sown spontaneously or by
birds; but it is now being raised in regular plantations, the seeds
being sown two or three in a hole with a chili (_Capsicum_) seed, the
latter producing a quick-growing seedling which shades the sandal while
young.[2259] It is probable that the nurse-plant affords _sustenance_,
for it has been shown[2260] that _Santalum_ is parasitic, its roots
attaching themselves by tuber-like processes to those of many other
plants; and it is also said that young sandal plants thrive best when
grass is allowed to grow up in the seed-beds.

The trees attain their prime in 20 to 30 years, and have then trunks
as much as a foot in diameter. A tree having been felled, the branches
are lopped off, and the trunk allowed to lie on the ground for several
months, during which time the white ants eat away the greater part of
the inodorous sapwood. The trunk is then roughly trimmed, sawn into
billets 2 to 2½ feet long, and taken to the forest depots. There the
wood is weighed, subjected to a second and more careful trimming, and
classified according to quality. In some parts it is customary not to
fell but to dig the tree up; in others the root is dug up after the
trunk has been cut down,—the root affording valuable wood, which with
the chips and sawdust are preserved for distillation, or for burning in
the native temples. The sap wood and branches are worthless.[2261]

[2257] B. H. Baden Powell, _Report on the Administration of the Forest
Department in the several provinces under the Government of India_,
1872-73, Calcutta, 1874. vol i. 27.

[2258] _Report of the Administration of the Madras Presidency during
the year 1872-73_, Madras, 1874. 18. 143.

[2259] Beddome, _Flora Sylvatica for Southern India_, 1872. 256.

[2260] Scott in _Journ. of Agricult. and Horticult. Soc. of India_,
Calcutta, vol. ii. part 1 (1871) 287.

[2261] Elliot, _Experiences of a Planter in the Jungles of Mysore_,
ii. (1871) 237; also verbal information communicated by Capt. Campbell
Walker, Deputy Conservator of Forests, Madras.

In 1863 a sort of sandal-wood afforded by _Fusanus spicatus_ (p. 599)
was one of the chief exports of Western Australia, whence it was
shipped to China. A trifling payment for permission to cut growing
timber of any kind was the only barrier placed on the felling of the
trees. The farmers employed their teams during the dull season in
bringing to Perth or Guildford the logs of sandal which had been felled
and trimmed in the bush; and there was a flourishing trade so long as
trees of a fair size could be obtained within 100 or even 150 miles
of the towns, where the commodity was worth £6 to £6 10_s._ per ton.
But the ill-regulated and improvident destruction of the trees in the
more easily accessible districts has so reduced their numbers that the
trade in that part of Australia soon came to an end.[2262] Australian
sandal-wood appears however to be still an article of commerce, if one
may draw such an inference from the fact that 47,904 cwt. of sandal
wood were imported into Singapore from Australia in the year 1872. It
was mostly re-shipped to China.[2263]

=Description=—sandal-wood is not much known in English commerce, and
is by no means always to be found even in London. That which we have
examined, and which we believe was Indian, was in cylindrical logs,
mostly about 6 inches in diameter (the largest 8 inches—smallest 3:
inches) and 3 to 4 feet long, extremely ponderous; the bark had been
removed. A transverse section of sandal-wood exhibits it of a pale
brown, marked with rather darker concentric zones and (when seen under
a lens) numerous open pores. The tissue is traversed by medullary rays,
also perceptible by the aid of a lens. The wood splits easily, emitting
when comminuted an agreeable odour which is remarkably persistent; it
has a strongish aromatic taste.

The varieties of sandal-wood are not classified by the few persons
who deal in the article in London, and we are unable to point out
characters by which they may be distinguished. In the price-currents of
commercial houses in China three sorts of sandal-wood are enumerated,
namely, _South Sea Island_, _Timor_, and _Malabar_; the last fetches
three or four times as high a price as either of the others. Even the
Indian sandal-wood may vary in an important manner. Beddome,[2264]
conservator of forests in Madras, and an excellent observer, remarks
that the finest sandal-wood is that which has grown slowly on rocky,
dry and poor land; and that the trees found in a rich alluvial soil,
though of very fine growth, produce no heartwood and are consequently
valueless. A variety of the tree with more lanceolate leaves (var.
β _myrtifolium_ DC.), native of the eastern mountains of the Madras
Presidency, affords a sandal-wood which is nearly inodorous.

=Microscopic Structure=—The woody rays or wedges show a breadth varying
from 35 to 420 mkm., the primary being frequently divided by secondary
medullary rays. These latter rays consist of one, often of two, rows
of cells of the usual form. The woody tissue which they enclose is
chiefly made up of small ligneous fibres with pointed ends, some larger
parenchymatous cells, and thick-walled vessels. The resin and essential
oil reside chiefly in the medullary rays, as shown by the darker colour
of these latter.

=Chemical Composition=—The most important constituent is the essential
oil, which the wood yields to the extent of from 2 to 5 per cent.[2265]
In India, with imperfect stills, 2·5 per cent. of the oil are obtained;
the roots yield the largest amount and the finest quality of it.[2266]
It is a light yellow, thick liquid, possessing the characteristic odour
of sandal; that which we examined had a sp. gr. of 0·963. We did not
succeed in finding a fixed boiling point of the oil; it began to boil
at 214° C., but the temperature quickly rose to 255°, the oil acquiring
a darker hue. Oil of sandal-wood varies much in the strength and
character of its aroma, according to the sort of wood from which it is
produced.

[2262] Millett, _An Australian Parsonage_, Lond., 1872, 43. 95. 382.

[2263] _Straits Settlements Blue Book for 1872_, Singapore, 1873. 298.
347.—It is possible that the sandal-wood in question may have been the
produce of the South Sea Islands, shipped from an Australian port.

[2264] _Op. cit._

[2265] Information obligingly communicated by Messrs. Schimmel and Co.,
Leipzig (1878).

[2266] Dr. Bidie, in _Pharmacopœia of India_, 1868, p. 461.

The oil as largely prepared by Messrs. Schimmel & Co., in a column
100 millimetres long, deviates the plane of polarization 18·6° to
the _left_. Oil of Venezuela sandal-wood, from the same distillers,
examined in the same manner, deviates 6°·75 to the _right_.

From the wood, treated with boiling alcohol, we obtained about 7 per
cent. of a blackish extract, from which a tannate was precipitated
by alcoholic solution of acetate of lead. Decomposed by sulphuretted
hydrogen, the tannate yielded a tannic acid having but little colour,
and striking a greenish hue with a ferric salt. The extract also
contained a dark resin.

=Commerce=—The greatest trade in sandal-wood is in China, which country
in the year 1866 imported at the fourteen treaty ports then open 87,321
peculs, equivalent to 5,197 tons; of this vast quantity the city of
Hankow on the river Yangtsze, received no less than 61,414 peculs, or
more than seven times as much as any other port.[2267] The imports into
Hankow have recently been much smaller, namely, 14,989 peculs in 1871
and 12,798 peculs in 1872.[2268] On the other hand, Shanghai lying near
the mouth of the same great river, imported in 1872, 59,485 peculs of
sandal-wood, the estimated value of which was about £100,000. In 1877
the imports of all China were 72,934 peculs.

A considerable trade in sandal-wood is done in Bombay, the quantity
imported thither annually being about 650 tons, and the animal export
about 400 tons.[2269]

Oil of sandal-wood is largely manufactured on the ghats between
Mangalore and Mysore, where fuel for the stills is abundant. Official
returns[2270] represent the quantity of the oil imported into Bombay
in the year 1872-73 as 10,348 lbs., value £8,374; 4,500 lbs. were
re-exported by sea.

=Uses=—The essential oil has of late been prescribed as a substitute
for copaiba, otherwise sandal-wood has hardly any uses in modern
European medicine. It is employed as a perfume and for the fabrication
of small articles of ornament. Among the natives of India it is
largely consumed in the celebration of sepulchral rites, wealthy
Hindus showing their respect for a departed relative by adding sticks
of sandal-wood to the funereal pile. The powder of the wood made into
a paste with water is used for making the caste mark, and also for
medicinal purposes. The consumption of sandal-wood in China appears to
be principally for the incense used in the temples.

[2267] _Reports on Trade at the ports in China open to foreign trade
for 1866_, published by order of the Inspector-General of Customs,
Shanghai, 1867. 120. 121.—One pecul = 133⅓ lb.

[2268] _Commercial Reports of H. M. Consuls in China for 1871_ (p. 50)
and 1872 (pp. 62. 159).

[2269] From the official document quoted at p. 601, note 1.

[2270] See p. 333, note 3.




_Gymnosperms._




CONIFERÆ.


TEREBINTHINA VULGARIS.

_Crude or Common Turpentine_; F. _Térebenthine commune_; G. _Gemeiner
Terpenthin_.

=Botanical Origin=—The trees which yield Common Turpentine may be
considered in two groups, namely, European and American.

1. _European_—In Finland and Russia Proper, the Scotch Pine, _Pinus
sivestris_ L.; in Austria and Corsica, _P. Laricio_ Poiret; and in
South-western France, _P. Pinaster_ Solander (_P. maritima_ Poiret),
extensively cultivated as the _Pin maritime_, yield turpentine in their
respective countries.

2. _American_—In the United States, the conifers most important for
terebinthinous products are the Swamp Pine, _Pinus australis_ Michaux
(_P. palustris_ Mill.), and the Loblolly Pine, _P. Tæda_ L.

=History=—The resin of pines and firs was well known to the ancients,
who obtained it in much the same manner as that practised at the
present day. The turpentine used in this country has for many years
past been derived from North America. Up to the last century, both
it and the substance called _Common Frankincense_ were imported from
France. The late civil war in the United States and the blockade of the
Southern ports, occasioned a great scarcity of American turpentine; and
terebinthinous substances from all other countries were poured into the
London market. The actual supplies, however, were mainly furnished by
France.

Kopp[2271] quotes a passage showing that the essential oil of
turpentine was known to Marcus Græcus, who termed it _Aqua ardens_.
This almost unknown personage is the reputed inventor of _Greek Fire_,
a dreaded engine of destruction in mediæval warfare.

=Secretion=—The primary formation of resin-ducts in the bark of
coniferous trees has been explained by Dippel,[2272] Müller,[2273] and
Frank.[2274] The subsequent diffusion of the resinous juice through
the heartwood, sapwood, and bark, has been elaborately investigated by
Hugo von Mohl.[2275] From the various forms under which this diffusion
exists in the different species have arisen the diverse methods of
obtaining the terebinthinous resins.

[2271] _Geschichte der Chemie_, iv. (1847) 392.

[2272] _Botanische Zeitung_, 1863.

[2273] Pringsheim, _Jahrb. für wissenschaftl. Botanik._ 1866.

[2274] _Beiträge zur Pflanzenphysiologie_, Leipzig, 1868. 119.

[2275] _Botanische Zeitung_, 1859. 329.

Thus in the wood of the Silver Fir (_Pinua Picea_ L.) resin-ducts are
altogether wanting;—and led by experience, the Alpine peasant collects
the turpentine of this tree by simply puncturing the little cavities
which form under its bark. In the Scotch Pine (_P. silvestris_ L.),
they are more abundant in the wood than in the bark, a fact which
might be anticipated by observing how rarely this tree exudes resin
spontaneously.

Oil of turpentine, like volatile oils in general, undergoes on
exposure to the air certain alterations giving rise to what is called
_resinification_. The formic acid which is produced in small quantity
during this change characterizes it as one of oxidation; the chief
products however are not exactly known, and not one of them has
been proved identical with any natural resin. The common assumption
that resins are produced from volatile oils by simple oxidation, is
consequently not yet entirely justified.

=Extraction=—In the United States[2276] turpentine is obtained to the
largest extent from _Pinus australis_, of which tree there are vast
forests, the piny woods or pine-barrens, extending from Virginia to the
Mexican Gulf, especially through North and South Carolina, Georgia and
Alabama. But it is in North Carolina that the extraction of turpentine
is principally carried on.

In the winter, _i.e._ from November to March, the negroes in a
_Turpentine Orchard_, as the district of forest to be worked is called,
are occupied in making in the trunks of the trees, cavities which
are technically known as _boxes_. For this purpose a long narrow axe
is used, and some skill is required to wield it properly. The boxes
are made from 6 to 12 inches above the ground, and are shaped like a
distended waistcoat-pocket, the bottom being about 4 inches below the
lower lip, and 8 or 10 below the upper. On a tree of medium size, a box
should be made to hold a quart. The less the axe approaches the centre
of the tree the better, as vitality is the less endangered. An expert
workman will make a box in less than 10 minutes. From one to four boxes
are made in each tree, a few inches of bark being left between them.
The greater number of trees from which turpentine is now obtained, are
from 12 to 18 inches in diameter, and have three boxes each.

The boxes having been made, the bark and a little of the wood
immediately beneath it, which are above the box, are _hacked_; and from
this excoriation, the sap begins to flow about the middle of March,
gradually filling the box. Each tree requires to be freshly hacked
every 8 or 10 days, a very slight wound above the last being all that
is needed. The hacking is carried on year after year, until it reaches
12 to 15 feet or more, ladders being used. The turpentine, which is
called _dip_, is removed from the boxes by a spoon or ladle of peculiar
form, and collected into barrels, which are made on the spot and are of
very rude construction. The first year’s flow of a new tree, having but
a small surface to traverse before it reaches the box, is of special
goodness and is termed _Virgin dip_.

[2276] The account here given is taken from F. L. Olmsted’s _Journey in
the Seaboard Slave States_, New York, 1856, p. 338, etc.

The turpentine which concretes upon the trunk is occasionally scraped
off and barrelled by itself, and is known in the market as _scrape_, or
by English druggists as _Common Frankincense_ or _Gum thus_.

Although a large amount of turpentine is shipped to the northern ports
for distillation, a still larger is distilled in the neighbourhood of
the turpentine orchards. Copper stills are used, capable of containing
5 to 20 barrels of turpentine. The turpentine is distilled without
water, the volatile oil as it flows from the worm being received in
the barrel in which it is afterwards sent to market. When all the oil
that can be profitably drawn off has been obtained, a spigot is removed
from an opening in the bottom of the still, and the residual _Rosin_,
appearing as a viscid fluid-like molasses, is allowed to flow out. Only
the first qualities of rosin, as that obtained from _Virgin dip_, are
generally considered worth saving, the less pure sorts being simply
allowed to run to waste. When it is intended to save the rosin, the
latter is drawn off into a vat of water, which separates the chips and
other rubbish, and the rosin is then placed in barrels for the market.
A North Carolina turpentine orchard will remain productive under
ordinary treatment for fifty years.

The collection of turpentine in the departments of the Landes and
Gironde in the south-west of France, is performed in a more rational
manner than in America, inasmuch as the plan of making deep cavities
in the tree for the purpose of receiving the resin, is avoided by
the simple expedient of placing a suitable vessel beneath the lowest
incision.[2277] The turpentine which concretes upon the stem is termed
in France _Galipot_ or _Barras_.

[2277] For further particulars, see Guibourt, _Hist. des drog._ ii.
(1869) 259, also Curie, _Produits résineux du Pin maritime_. Paris
1874. 24 pages, 1 plate; Matthieu, _Flore forestière_ 1860, p. 353.

=Description=—Common turpentine is chiefly of two varieties, namely,
_American_ and _Bordeaux_; the first alone is commonly found in the
English market.

_=American Turpentine=_—A viscid honey-like fluid, of yellowish colour,
somewhat opaque, but becoming transparent by exposure to the air; it
has an agreeable odour and warm bitterish taste. When long kept in a
bottle, it is seen to separate into two layers, the upper clear and
faintly fluorescent, the lower somewhat turbid or granular. When the
latter portion is examined under the microscope, it is found to consist
mainly of minute crystals of peculiar curved or bluntly elliptic form.
These crystals are abietic acid; when the turpentine is warmed, the
crystals are speedily dissolved.

_Bordeaux Turpentine_—in all essential particulars agrees with American
Turpentine; it appears to separate rather more readily than the latter
into two layers,—a transparent and an opaque or crystalline.

=Chemical Composition=—The turpentines are mixtures of resin and
essential oil. The latter, which amounts to from 15 to 30 per cent.,
consists for the greater part of various hydrocarbons, corresponding
to the formula C₁₀H₁₆. Many of the crude turpentine oils, and some of
them even after rectification, are energetically acted on by metallic
sodium. This reaction proves the presence of a certain quantity of
oxygenated oils, not one of which has thus far been isolated.

The turpentine oils, although agreeing in composition, exhibit a
series of physical differences according to their origin. One and the
same tree, indeed, yields from its several organs oils of different
properties. The boiling point varies between 152° and 172° C. The
sp. gr. at mean temperatures ranges from 0·856 to 0·870. Greater
differences are exhibited in the optical properties, some varieties
of the oil turning the plane of polarization to the right, others to
the left. This rotatory power differs in many cases from that of the
turpentine from which the oil was derived.[2278] The odour of oil of
turpentine varies with the species from which it has been obtained.

When crude turpentine is distilled with water, nearly the whole of
the oil passes over, while the resin remains. This resin is called
_Colophony_ or _Rosin_. When it still contains a little water, it is
distinguished in English trade as _Yellow Rosin_; when fully deprived
of water, it becomes what is called _Transparent Rosin_. That of deeper
colour acquired by a still longer application of heat, bears the name
of _Black Rosin_.

Colophony softens at 80° C., and melts completely at 100° into a clear
liquid. At about 150° it forms a somewhat darker liquid, but without
undergoing a loss in weight; at higher temperatures, it gradually
decomposes. Pure colophony has a sp. gr. of 1·07, and is homogeneous,
transparent, amorphous, and very brittle. At temperatures between 15°
and 20° C., it requires for solution 8 parts of dilute alcohol (0·883).
On addition of a caustic alkali, it dissolves in spirit much more
freely. It is plentifully soluble in acetone or benzol.

The composition of colophony agrees with the formula C₄₄H₆₂O₄. By
shaking coarsely powdered colophony with warm dilute alcohol, it is
converted into a crystalline body, _Abietic Acid_, C₄₄H₆₄O₅,—a result
due simply to hydration. Under such treatment, colophony yields 80 to
90 per cent. of abietic acid,[2279] and therefore consists chiefly of
the anhydride of that acid. This is probably the case with the resins
of other conifers. The living tree contains only the anhydride, for
the fresh resinous juice is clear and amorphous after the expulsion
of the oil; and when exposed to the air it loses oil, takes up water
and solidifies as the crystalline acid,—a change which may easily be
traced by the aid of the microscope, in drops taken direct from the
trunk. Amorphous colophony retains its transparency even in a moist
atmosphere, and appears to be capable of passing into the state of
abietic acid, only when the assumption of the needful molecule of
water is aided, in nature by the presence of the essential oil, or
artificially by that of alcohol.

[2278] For some particulars, see my notice in the _Jahresbericht_ of
Wiggers and Husemann for 1869, p. 36.—F. A. F.

[2279] Flückiger in _loc. cit._ 1867. 36.—Most chemists assign to this
acid the formula C₂₀H₃₀O₂, and call it _silvic acid_.

Colophony when boiled with alkaline solutions forms greasy salts of
abietic acid, the so-ccalled _resin-soaps_, which are used as additions
to other soaps.

Siewert’s _Silvic Acid_ is regarded by Maly (1864) as a product of the
decomposition of abietic acid; and the _Pimaric_, _Pinic_ and _Silvic
Acids_ of former investigators, as impure abietic acid. Pimaric acid
however, which is the chief constituent of _Galipot_, appears to be
decidedly different, so far as we can judge from the experiments of
Duvernoy (1865) and of one of ourselves (F.).

Abietic acid, as well as the unaltered coniferous resins, deviate
the ray of polarized light, whereas American colophony, dissolved in
acetone, is devoid of optical power.

=Commerce=—The supplies of turpentine are chiefly derived from the
United States, but the trade has undergone a great change, as shown by
the following figures, which represent the quantities imported in the
several years:—

       1869       1870         1871        1872
    60,468 cwt.  51,257 cwt.  2,231 cwt.  1,000 cwt.

This greatly diminished importation of the crude article is partially
explained by a larger importation of Oil of Turpentine and Rosin;
but the increase is by no means sufficient to account for the vast
diminution indicated by the above figures. The quantities of these
latter articles imported into the United Kingdom during the year 1872
were as follows:—_Oil of Turpentine_, 220,292 cwt., value £470,085,
six-sevenths being furnished by the United States of America and the
remainder chiefly by France. _Rosin_, 919,494 cwt., value £492,246; of
this quantity, the United States supplied nine-tenths, and France the
larger part of the remainder.[2280]

=Uses=—Turpentine, Common Frankincense and Colophony are ingredients
of certain plasters and ointments. Oil of turpentine is occasionally
administered internally as a vermifuge or diuretic, and applied
externally as a stimulant. But these substances are immeasurably less
important in medicine than in the arts.

Thus Americanum vel vulgare.

This substance, known among druggists as _Common Frankincense_ or _Gum
Thus_, is the resin which, as explained at p. 605, concretes upon the
stems of the pines in the American turpentine orchards, and is there
called _Scrape_. It corresponds to the _Galipot_ or _Barras_ of the
French, which in old times supplied its place.

It is a semi-opaque, softish resin, of a pale yellow colour, smelling
of turpentine; it is generally mixed with pine leaves, bits of wood
and other impurities, so that it requires straining before it is used.
By keeping, it becomes dry and brittle, of deeper colour and milder
odour. Under the microscope, it exhibits a crystalline structure due
to _Abietic Acid_, of which it chiefly consists. It is imported from
America in barrels, but in insignificant quantities and only for
the druggist’s use. Sometimes, however, it is distilled as common
turpentine.

Dry pine resin, of which Common Frankincense is the type, evolves when
heated an agreeable smell; hence in ancient times it was commonly used
in English churches in place of the more costly olibanum. At present it
is scarcely employed except in a few plasters.

[2280] _Annual Statement of the Trade of the U.K. for 1872._ pp. 53.
56. 60. 210.


TEREBINTHINA VENETA.

    _Terebinthina Laricina_; _Venice Turpentine_,
        _Larch Turpentine_; F. _Térébenthine de
        Venise ou de Briançon_, _Térébenthine du
        mélèze_; G. _Venetianischer Terpenthin_,
        _Lärchen-Terpenthin_.

=Botanical Origin=—_Pinus Larix_ L. (_Larix europæa_ DC.), a tall
forest tree of the mountains of Southern Central Europe, from Dauphiny
through the Alps to Styria and the Carpathians, ascending to an
elevation of 3000 to 5500 feet above the sea-level. It is largely grown
in plantations in England and also, since 1738, in Scotland.

=History=—The turpentine of the larch was known to Dioscorides as
imported from the Alpine regions of Gaul.[2281] Pliny also was
acquainted with it, for he correctly remarks that it does not harden.
Galen in the 2nd century also mentions it, admitting that it may well
be substituted for Chian turpentine (see p. 165), the true, legitimate
_Terebinthina_. Yet even in the beginning of the 17th century many
pharmacologists complained of such a substitution. Mattioli[2282] gave
an account of the method of collecting it about Trent in the Tirol,
by boring the trees to the centre, which is true to the present day.
It used formerly to be exported from Venice, then the great emporium
for drugs of all kinds; the turpentine may even at times have been
collected in the territories of the Venetian republic. We find it
expressly called _Terebinthina Veneta_ by Guintherus of Andernach.[2283]

The name _larch_ seems to belong to the turpentine rather than to the
tree. Dioscorides says the resin is called by the natives λάρικα, and
a similar name is mentioned by Galen. In Pasi’s _Tariffa de pesi e
misure_, 1521 (see Appendix), we find “_Termentina sive Larga_,”—and
_larga_ is still an Italian name for larch turpentine. The peasants of
the Southern Tirol call it _Lerget_, and in Switzerland the common name
in German is _Lörtsch_.

=Extraction=—Larch turpentine is collected in the Tirol, chiefly
about Mals, Meran, Botzen and Trent. A very small amount is obtained
occasionally in the Valais in Switzerland, and in localities in
Piedmont and France where the larch is found. The resin is obtained
from the heartwood, by making in the spring a narrow cavity reaching to
the centre of the stem at about a foot from the ground. This is then
stopped up until the autumn of the same or of the following year, when
it is opened and the resin taken out with an iron spoon. If only one
hole is thus made, the tree yields about half a pound yearly without
appreciable detriment. But if on the other hand a number of wide holes
are made, and especially if they are left open, as was formerly the
practice in the Piedmontese and French Alps, a larger product amounting
to as much as 8 lb. is obtained annually, but the tree ceases to yield
after some years, and its wood is much impaired in value.

[2281] Lib. i. cap. 92.

[2282] _Comment. in libr. i. Dioscoridis_, Venetiis, 1565. 106.

[2283] _De medicina veteri et nova etc._, Basileæ, 1571. 183.

Mohl, who witnessed the collection of this turpentine in the Southern
Tirol,[2284] observed that when a growing larch stem was sawn through,
the resin flowed most abundantly from the heartwood, and in smaller
quantity, though somewhat more quickly, from the sapwood, and that
the bark contained but few resin-ducts. The practice of closing the
cavities is adopted, not only for the sake of preserving the wood
and for the greater convenience of removing the turpentine, but also
because it tends to maintain the transparency and purity of the latter.

=Description=—Venice turpentine is a thick, honey-like fluid, slightly
turbid, yet not granular and crystalline; it has a pale yellowish
colour and exhibits a slight fluorescence. Its odour resembles that
of common turpentine, but is less powerful; its taste is bitter and
aromatic. When exposed to the air, it thickens but slowly to a clear
varnish, and hardens but very slowly when mixed with magnesia. Larch
turpentine, though common on the Continent, is seldom imported into
England,[2285] and the article sold for it is almost always spurious.

=Chemical Composition=—Larch turpentine dissolves in spirit of wine,
forming a clear liquid which reddens litmus; hot water agitated with it
also acquires a faint acid reaction, due to formic and probably also
to succinic acid. Glacial acetic acid, amylic alcohol, and acetone
mix with it perfectly. By distillation it yields on an average 15 per
cent. of essential oil of the composition, C₁₀H₁₆, which boils at 157°
C., and when saturated with dry hydrochloric acid gas, easily produces
crystals of the compound C₁₀H₁₆ + HCl. The residual resin is soluble
in two parts of warm alcohol of 75 per cent., and more copiously in
concentrated alcohol.

Two parts of the turpentine diluted with one of benzol or acetone
deviate the ray of polarized light 9·5° to the _right_. The essential
oil deviates 6·4° to the _left_; the resin perfectly freed from
volatile oil and dissolved in half its weight of acetone, deviates
12·6° to the _right_ in a column 50 mm. long.

We have not succeeded in preparing a crystallized acid from the resin
of Venice turpentine, although its composition according to _Maly_
(1864) is the same as that of American colophony, which is easily
transformed into crystallized abietic acid.

=Uses=—Venice turpentine appears to possess no medicinal properties
that are not equally found in other substances of the same class, and
as a medicine it has fallen into disuse. But in name at least it is in
frequent requisition for horse and cattle medicines.

=Adulteration=—Alston (1740-60) said of Venice turpentine[2286] that
it is seldom found in the shops,—a remark equally true at the present
day, for but few druggists trouble themselves to procure it genuine.
The Venice turpentine usually sold is an artificial mixture of common
resin and oil of turpentine, which may be easily distinguished from the
product of the larch by the facility with which it dries when spread on
a piece of paper,[2287] and by its stronger turpentine smell.

[2284] _Botanische Zeitung_, xvii. (1859) 329, abstracted in the
_Jahresbericht_ of Wiggers, 1859. 18.

[2285] On one occasion I observed Venice Turpentine in a public drug
sale in London, 21 barrels imported from Trieste being offered, 14
July, 1864.—D. H.

[2286] _Lectures on the Materia Medica_, Lond. ii. (1770) 398.

[2287] Thus if a thin layer of true Venice turpentine and another of
common turpentine be spread on two sheets of paper it will be found
after the lapse of some weeks that the former cannot be touched without
adhering to the fingers, while the latter will have become a dry, hard
varnish.


CORTEX LARICIS.

_Larch Bark._

=Botanical Origin=—_Pinus Larix_ L.—see p. 609.

=History=—The bark of the larch has long been known to possess
astringent properties; hence it has been used in tanning.
Gerarde,[2288] who wrote near the close of the 16th century, likened it
to that of the pine, which he described to be of a binding nature; but
there is no evidence that it was an officinal drug.

About the year 1858 larch bark was recommended by Dr. Frizell of
Dublin, and afterwards by other physicians, as a stimulating astringent
and expectorant. In consequence of the favourable effects which have
resulted from its use it has been included in the _Additions to the
Pharmacopœia of 1867_.

=Description=—The bark that we have seen is in flattish pieces or
large quills, externally reddish-brown. In those taken from older wood
there is a large amount of an exfoliating corky coat, displaying as
it is removed bright rosy tints, while the liber is of a different
texture, slightly fibrous and whitish. The inner surface is smooth
and of a pinkish-brown, or pale yellow. The bark breaks with a short
fracture, exhaling an agreeable balsamic terebinthinous odour; it has a
well-marked astringent taste. For medicinal use the inner bark is to be
preferred.

=Microscopic Structure=—A transverse section exhibits resin-ducts, but
far less numerous than in the bark of many allied trees. The medullary
rays are not very distinct. Throughout the middle layer of the bark
large isolated thick-walled cells of very irregular shape are scattered.

=Chemical Composition=—Larch bark has been examined by Stenhouse,[2289]
who finds it to contain a considerable amount of a peculiar tannin,
yielding olive-green precipitates with salts of iron. The same chemist
also discovered[2290] in larch bark an interesting crystallizable
substance called _Larixin_ or _Larixinic Acid_, which has the
composition C₁₀H₁₀O₅. It may be obtained by digesting the bark in
water in 80° C. and evaporating the infusion to a syrupy consistence.
From this, by still further cautious heating in a retort, the larixin
may be distilled, during which operation some of it crystallizes on
the inner surface of the receiver, the remainder being dissolved in
the distilled liquor. From the latter it may be obtained in crystals
by evaporation. The substance forms colourless crystals, sometimes
as much as an inch long; it volatilizes even at 93° C., and melts at
153°. It requires about 88 parts of water for solution at 15° C., but
more freely dissolves in boiling water or in alcohol. From ether, in
which it is but sparingly soluble, it separates in brilliant crystals.
The solutions have a bitterish astringent taste and a slightly acid
reaction, and assume a purple hue on addition of ferric chloride. When
a solution of baryta is added to a concentrated solution of larixin,
the latter being in excess, a bulky gelatinous precipitate falls; it
is readily soluble in boiling water and is deposited again on cooling.
Stenhouse failed to obtain it either from the bark of _Pinus Abies_ L.,
or from that of _P. silvestris_ L.

[2288] _Herball, enlarged by Johnson_, Lond. 1636. 1366.

[2289] _Proceedings of the Royal Society_, xi. (1862) 404.

[2290] _Phil. Trans._, vol. 152 (1862) 53.—We write the name _Larixin_
instead of _Larixine_, with the concurrence of Dr. Stenhouse.

=Uses=—Larch bark, chiefly in the form of tincture, has been prescribed
to check profuse expectoration in cases of chronic bronchitis; it has
also been found useful in arresting internal hæmorrhage.


TEREBINTHINA CANADENSIS.

_Balsamum Canadense_; _Canada Balsam_, _Canadian Turpentine_; F.
_Térébenthine ou Baume de Canada_; G. _Canada Balsam_.

=Botanical Origin=—_Pinus balsamea_ L. (_Abies balsamea_ Marshall), the
Balsam Fir or Balm of Gilead Fir, a handsome tree, 20 to 40 feet high,
with a trunk 6 to 12 inches in diameter, sometimes attaining still
larger dimensions, growing in profusion in the Northern and Western
United States of America, Nova Scotia and Canada, but not observed
beyond 62° N. lat. It resembles the Silver Fir of Europe (_Pinus Picea_
L.), but has the bracts short-pointed and the cones more acute at each
end.

Canada balsam is also furnished by _Pinus Fraseri_ Pursh, the
Small-fruited or Double Balsam Fir, a tree found on the mountains
of Pennsylvania, Virginia, and southward on the highest of the
Alleghanies.[2291]

_Pinus canadensis_ L. (_Abies canadensis_ Michx.), the Hemlock Spruce
or Pérusse, a large tree abundant in the same countries as _P.
balsamea_, and extending throughout British America to Alaska, is
said to yield a similar turpentine, which however has not yet been
sufficiently examined. The Hemlock Spruce is of considerable importance
on account of the resin collected from its trunk, and the essential oil
distilled from its foliage, the latter operation being performed on a
large scale in Madison County, New York. The inner bark of the tree is
a valuable material for tanning.

=History=—The French, in whose possession Canada remained until the
year 1763, were probably acquainted with Canada balsam long before
this period. Yet no mention of it is found in Pomet’s work, but in
1759 it was at Strassburg a current article of the pharmacy.[2292] As
to England, Lewis, in his _History of the Materia Medica_ published in
1761, says that “_an elegant balsam_,” obtained from the Canada Fir, is
sometimes brought into Europe under the name of _Balsamum Canadense_.
Canada balsam was first introduced into the London Pharmacopœia in
1788. From the books of a London druggist, J. Gurney Bevan, we find
that its wholesale price in 1776 was 4_s._, in 1788, 5_s._ per lb.

=Description=—Canada balsam is a transparent resin of honey-like
consistence, and of a light straw-colour with a greenish tint. By
keeping, it slowly becomes thicker and of a somewhat darker hue, but
always retains its transparency. When carefully examined in direct
sunlight, it exhibits a slight greenish fluorescence in the same degree
as other turpentines or as copaiba; this optical power appears to
increase if the balsam is exposed to a heat of about 200° C.

[2291] Asa Gray, _Botany of the Northern United States_, New York,
1866. 422.

[2292] Flückiger, _Pharm. Journ._ vi. (1876), 1021.

Canada balsam has a pleasant aromatic odour and bitterish, feebly
acrid, not disagreeable taste. On account of its flavour it is
sometimes called _Balm of Gilead_, but erroneously, as this latter is
derived from a tree of the genus _Balsamodendron_ growing in Arabia.
We found a good commercial balsam to have a sp. gr. of 0·998 at 14·5°
C., water at the same temperature being 1·000. Four parts, mixed with
one of benzol and examined in a column of 50 mm. in length, deviated
a ray of polarized light 2° to the right. The balsam is perfectly
soluble in any proportion in chloroform, benzol, ether, or warm amylic
alcohol; and the solution in each case reddens litmus. With sulphate
of carbon it mixes readily, but the mixture is somewhat turbid.
Glacial acetic acid, acetone or absolute alcohol dissolve the balsam
partially, leaving, after ebullition and cooling, a considerable amount
of amorphous residue. Colophony and Venice turpentine are completely
dissolved by the liquids in question, as well as by spirit of wine
containing 70 to 75 per cent. of alcohol.

=Chemical Composition=—Like all analogous exudations of the _Coniferæ_,
Canada turpentine is a mixture of resins with an essential oil. If the
latter is allowed to evaporate, the former are left as a transparent,
somewhat tough and elastic mass. The proportion of the components is
within certain limits, variable in different samples. The specimen
before mentioned lost after an exposure in a steam-bath during several
days, no less than 20 per cent. of volatile oil, or even 24 per cent.
if the experiment was made on a very small scale, as with 20 grammes or
less in a thin layer.

By distillation with water, it is not easy to obtain more than 17 to
18 per cent. of essential oil. The resin in this case is a tough,
elastic, non-transparent mass, retaining obstinately a large proportion
of water, which can only be removed by keeping it for some time at a
temperature of 100°-176° C.

The oil as obtained by distillation with water is colourless, and
has the odour of common oil of turpentine rather than the agreeable
smell of the balsam; it consists of an oil, C₁₀H₁₆, mixed with an
insignificant proportion of an oxygenated oil, the presence of which
may be proved by the slight evolution of hydrogen on addition of
metallic sodium, after the oil has been freed from water by contact
with fused chloride of calcium. After this treatment, a small
proportion begins to distil at about 160°, but by far the larger part
boils at 167° C., a small portion only distilling at last at 170° and
above. The oil obtained at 167°, examined under the conditions already
mentioned, has a sp. gr. of 0·863, and the power of rotating a ray of
polarized light 5·6° to the left. The portion distilling at 160° does
not differ in this respect; but that passing over at 170°, deviates the
ray 7·2° to the left. The oil readily dissolves a large proportion of
glacial acetic acid; an equal weight of each mixes perfectly at about
54° C., but some acetic acid separates on cooling.

The essential oil of Canada balsam, saturated with dry hydrochloric
acid, does not yield a solid crystallizable compound; but this is
easily obtained on addition of fuming nitric acid and gently heating,
when the inside of the retort becomes covered by sublimed crystals of
C₁₀H₁₆ + HCl.

Thus this oil in its general characters bears a close resemblance
to the essential oils of the cones of _Pinus Picea_ L., and of the
leaves of _P. Pumilio_ Hänke, and to most of the French varieties of
oil of turpentine, rather than to the American turpentine oils, which
rotate to the right, and combine immediately with HCl to form a solid
crystalline compound.

On the other hand, the resin of Canada balsam is dextrogyre: two parts
of it, entirely deprived of essential oil and dissolved in one of
benzol, deviating the ray 8·5° to the right. The optical powers of the
two components (oil and resin) are therefore antagonistic.

The resin of Canada balsam consists however of two different bodies,
78·7 per cent. of it being soluble in boiling absolute alcohol, and
21·3 (in our specimen) remaining as an amorphous mass, readily soluble
in ether. Neither the alcoholic nor the ethereal solution yields a
crystalline residue if allowed to evaporate. They redden litmus, but we
did not succeed in obtaining any crystallized resinous acid, crystals
of which are formed if common turpentine or colophony is digested with
dilute alcohol. Glacial acetic acid acts upon the resins like absolute
alcohol. Caustic alkalis do not dissolve either the balsam or the
resin; the former however is considerably thickened by incorporation
with ⅕ of its weight of recently calcined magnesia. If the mixture,
moistened with dilute alcohol, is kept at 93° C. for some days and
frequently stirred, a mass of hard consistence, finally translucent,
results. Caustic ammonia heated with the balsam in a closed bottle,
forms a thick milky jelly, which does not afterwards separate.

Hence, according to our investigations, 100 parts of Canada turpentine
consist of

    Essential oil, C₁₀H₁₆}, with a very small proportion of
      an oxygenated oil                                         24
    Resin soluble in boiling alcohol                            60
    Resin soluble only in ether                                 16

The result of Wirzen’s examination of Canada balsam[2293] are not in
complete accordance with those here stated. He found 16 per cent.
of oil and three different amorphous resins, one of which had the
composition of abietic acid.

[2293] _De balsamis et præsertim de Balsamo Canadense_, Helsingforsiæ,
1849,—abstracted in the _Jahresbericht_ of Wiggers for 1849. 38.

=Production and Commerce=—Canada balsam is obtained either by
puncturing the vesicles which form under the suberous envelope of the
trunk and branches, and collecting their fluid contents in a bottle, or
by making incisions. It is obtained principally in Lower Canada, and
is shipped from Montreal and Quebec, in kegs or large barrels. In the
neighbourhood of Quebec, about 2000 gallons (20,000 lb.) used to be
collected annually; but in 1868, owing to distress among the farmers,
the quantity obtained was unusually large, and it was estimated that
nearly 7000 gallons would be exported to England and the United
States.[2294] During a recent scarcity (1872-73) a sort of balsam from
Oregon has been substituted in the American market for true Canada
balsam.[2295]

=Uses=—The medicinal properties of Canada balsam resemble those
of copaiba and other terebinthinous oleo-resins, yet it is now
rarely employed as a remedy. The balsam is much valued for mounting
objects for the microscope, as it remains constantly transparent and
uncrystalline. It is also used for making varnish.


TEREBINTHINA ARGENTORATENSIS.

_Strassburg Turpentine_; F. _Térébenthine d’Alsace ou de Strasbourg_,
_Térébenthine du sapin_; G. _Strassburger Terpenthin_.

=Botanical Origin=—_Pinus Picea_ L. (_Abies pectinata_ DC.), the Silver
Fir,[2296] a large handsome tree, growing in the mountainous parts
of Middle and Southern Europe from the Pyrenees to the Caucasus, and
extending under a slightly different form (var. β. _cephalonica_) into
continental Greece and the islands of Eubœa and Cephalonia.

=History=—Belon in his treatise _De Arboribus coniferis_ (1553)
described this turpentine, which is also briefly yet accurately noticed
by Samuel Dale,[2297] a learned apothecary of London and the friend of
Sloane and Ray. It had a place in the London Pharmacopœia until 1788,
when it was omitted from the materia medica.

=Extraction=—The oleo-resin of _P. Picea_, like that of _P. balsamea_,
is contained in little swellings of the bark[2298] of young stems, and
is extracted by the tedious process of puncturing them and receiving
in a suitable vessel the one or two drops which exude from each. It is
still collected near Mutzig and Barr, in the Vosges (1878), though only
to a very small extent.

=Description=—An authentic sample collected for one of us by the
Surveyor of Forests in the Bernese Jura, Switzerland, resembles very
closely Canada balsam, but is devoid of any distinct fluorescence. It
has a light yellow colour, a very fragrant odour,[2299] more agreeable
than that of Canada balsam, and is devoid of the acrid bitterish taste
of the latter.

We found our specimen to have sp. gr. of distilled water. It deviates
a ray of polarized light 3° to the left, if examined either pure or
diluted with a fourth of its weight of benzol, in the manner described
at p. 610. Our drug is soluble in the same liquids as the Canadian, yet
is miscible with glacial acetic acid, absolute alcohol and acetone,
without leaving any considerable flocculent residue. It is even soluble
in spirit of wine, the solution being but very little turbid. The
solutions have an acid reaction.

[2294] From information obligingly communicated by Mr. N. Mercer of
Montreal and Mr. H. Sugden Evans of London.—See also _Proc. Am. Pharm.
Assoc._, 1877, page 337, abstracted in _Ph. Jour._ viii. (1878) 813.

[2295] _Proceedings of the American Pharmaceutical Association_,
Philadelphia, 1873. 119—also 1874. 433.

[2296] _Sapin_ in French; _Weisstanne_ or _Edeltanne_ in German.

[2297] _Pharmacologia_, Lond. 1693. 395.

[2298] See Morel, _Ph. Jour._ viii. (1877) 21.

[2299] Hence it is sometimes called in French _Térébenthine au citron_.

=Chemical Composition=—After the complete desiccation of a small
quantity, there remained 72·4 per cent. of a brittle, transparent
resin, soluble in glacial acetic acid, but not entirely in absolute
alcohol or in acetone. By submitting half a pound of the turpentine to
distillation with water, we obtained 24 per cent. of essential oil,
the remaining resin being when cold perfectly friable. The fresh oil,
purified by sodium, deviates the ray of polarized light to the left,
whereas the remaining resin, dissolved in half its weight of benzol,
shows a weak dextrogyre rotation. The oil boils at 163° C. After having
kept it for two years and a half in a well-stopped bottle, we find that
it has become considerably thicker and now deviates to the right. If
saturated with dry hydrochloric acid, the oil does not yield a solid
compound.

This oil has nearly the same agreeable odour as the crude oleo-resin,
yet the essential oil of the _cones_ of the same tree is still more
fragrant. The latter is one of the most powerfully deviating oils,
the rotation being 51° to the left, and it is consequently extremely
different from the oil obtained from the turpentine of the stem, though
its composition is represented by the same formula, C₁₀H₁₆.

A peculiar sugar called _Abietite_, nearly related to mannite but
having the composition C₁₂H₁₆O₆, has been detected by Rochleder[2300]
in the leaves of the Silver Fir.

=Uses=—Strassburg turpentine possesses the properties of common
turpentine, with the advantage of a very agreeable odour. It was
formerly held in great esteem, but has now become nearly forgotten.


PIX BURGUNDICA.

_Pix abietina_; _Burgundy Pitch_; F. _Poix de Bourgogne ou des Vosges_,
_Poix jaune_; G. _Fichtenharz_, _Tannenharz_.

=Botanical Origin=—_Pinus Abies_ L. (_Abies excelsa_ DC.), the Norway
Spruce Fir,[2301] a noble tree attaining an elevation of 100-160 feet,
widely distributed throughout Northern and the mountainous parts of
Central Europe, but not indigenous to Great Britain, though extensively
planted. In Russian Lapland it reaches at 68° N. lat. almost the
extreme limit of tree-vegetation, while southward it extends to the
Spanish Pyrenees. In the Alps it ascends to 6,000 feet above the level
of the sea.

=History=—In accordance with the definition of the London
Pharmacopœias and the custom of English druggists the name _Burgundy
Pitch_ is restricted to the product of the above-named species.
The pharmacologists of France use an equivalent term with the same
limitations; but in other parts of the Continent _Pix Burgundica_ has
a wider meaning, and is allowed to include the turpentines of other
_Coniferæ_. We here employ it in the English sense.

Parkinson, an apothecary of London and herbarist to King Charles I.,
speaks of “_Burgony Pitch_” as a thing well known in his time.[2302]
Dale in his _Pharmacologia_ (1693) mentions _Pix Burgundica_ as being
imported into England from Germany, and it is also noticed by Salmon
(1693), who says “it is brought to us out of Burgundy, Germany and
other places near Strasburgh.”[2303]

[2300] Wiggers and Husemann, _Jahresbericht_, 1868. 53.

[2301] _Pesse_ or _Epicéa_ of the French; _Fichte_ or _Rothtanne_ of
the Germans.

[2302] _Theater of Plants_, 1640. 1542.

[2303] _Compleat English Physician_, 1693. 1031.

Pomet, writing in Paris about the same period, discards the prefix
_Burgundy_ as a fiction, remarking that the best _Poix grasse_ comes
from Holland and Strassburg.[2304]

Whether this resin ever was collected in Burgundy we are unable to
determine. It may probably have acquired the name through having been
brought into commerce from Switzerland and Alsace by way of Franche
Comté, otherwise called Comté de Bourgogne or Haute Bourgogne.[2305]

Burgundy pitch is enumerated among the materia medica of the London
Pharmacopœia of 1677, and in every subsequent edition. In that of 1809
it was defined under the name of _Pix arida_, as the _prepared resin of
Pinus Abies_.

=Production=—Burgundy pitch is produced in Finland, in the Black Forest
in the Grand Duchy of Baden, Austria and Switzerland. On the estate
of Baron Linder at Svarta near Helsingfors, it is obtained by melting
the crude resin in contact with the vapour of water, and straining.
The quantity annually produced there was stated in 1867 to be 35,000
kilogr. (689 cwt.);[2306] that afforded by an establishment at Ilm in
the same country amounted to 80,000 kilogr. (1,575 cwt.).[2307]

In the neighbourhood of Oppenau and on the Kniebis mountain in the
Grand Duchy of Baden the stems of the firs are wounded at equal
distances by making perpendicular channels, 1½ inches wide and the
same in depth. The resin which exudes from these channels is scraped
off with an iron instrument made for the purpose, and purified by
being melted in hot water and strained. This is performed in three or
four small establishments at Oppenau and the neighbouring village of
Löcherberg. In this state the resin, which is opaque and contains much
moisture, is called _Wasserharz_. By further straining and evaporating
a portion of the water its quality is improved.

The manufacture in that part of Germany is on the decline, partly in
consequence of the timber being injured by the wounding of the trees,
so that the collecting of resin is not permitted in the large forests
belonging to the governments of Baden and Württemberg. We have had the
opportunity of observing[2308] that in the establishments in question
French turpentine or _galipot_, imported from Bordeaux, as well as
American rosin or colophony, are used in quantities certainly exceeding
that of the resin grown on the spot.

In the middle of the last century some Burgundy pitch was produced,
according to Duhamel,[2309] in the present canton of Neuchâtel, but
no such branch of industry is now pursued there, at least on a large
scale. On the other hand, in the districts of Moutier and Delémont
in the Bernese Jura this resin is still collected, though it is not
known as _Burgundy Pitch_, but is termed simply _Poix blanche_ (White
Pitch). The surveyor of the forests of this district, which is one of
the richest in _Pinus Abies_, has informed one of us that from 790 to
850 quintals are collected and exported to Basle, Zürich, Aarau and
Vaud. The pitch is worth _in loco_ (1868) 100 to 110 francs (£4 to £4
8_s._) the _bosse_ of 6 quintals. The quantities collected in other
parts of Switzerland are even less considerable.

[2304] _Hist. des Drogues_, Paris, 1694. part i. 287.

[2305] Chabræus in his _Stirpium Sciagraphia_ (1666) remarks that he
had seen the _Pesse_ (_P. Abies_ L.) in great plenty “_in Burgundicis
montibus_,” yet makes no particular allusion to its yielding resin.

[2306] _Pharm. Journ._ ix. (1876) 164; also in Hanbury’s _Science
Papers_, pp. 46 to 53.

[2307] _Oesterreichischer Ausstellungs-Bericht_, x. (Wien, 1868) 471.

[2308] I spent several days in the localities in 1873.—F. A. F.

[2309] _Traité des Arbres_, etc. i. (1775) 12.

=Description=—Pure Burgundy pitch, of which we have numerous authentic
specimens, is a rather opaque, yellowish-brown substance, hard and
brittle when cold, yet gradually taking the form of the vessel in which
it is kept. It is strongly adhesive, breaks with a clear conchoidal
fracture, and has a very agreeable, aromatic odour, especially when
heated. It does not exhibit a crystalline structure, although, as
we have frequently observed, the resin on the stem of the tree is
distinctly crystalline.

Burgundy pitch is readily soluble in glacial acetic acid, acetone,
absolute alcohol, and even in alcohol of 75 per cent. (sp. gr. 0·860),
yet its solubility in these liquids is considerably altered by the
presence of water or essential oil; and still more by the formation of
abietic acid in the resin itself. The same influences also affect the
melting point.

The crude resin of _Pinus Abies_,[2310] deprived of essential oil and
dissolved in one part of absolute alcohol, was found to deviate a ray
of polarized light 3° to the left, in a column of 50 mm.; the essential
oil deviated 8·5° to the same direction. The oil contains a small
amount of an oxygenated oil. After treatment with sodium the oil which
remains does not form a solid compound if saturated with hydrochloric
acid.

[2310] Collected by myself.—F. A. F.

=Chemical Composition=—The investigations of Maly mentioned at p. 607
afford a satisfactory elucidation of the chemical properties of the
pinic resinous exudations. They all, according to that chemist, are
mixtures of the same amorphous resin, C₄₄H₆₂O₄, with essential oils of
the composition C₁₀H₁₆. These terebinthinous juices are collected and
sold either in their natural state as _turpentine_, or deprived more
or less completely of their volatile oil, in which condition they are
represented by _Burgundy Pitch_, and finally by _rosin_ or _colophony_.

The turpentines flowing down the stems of the trees gradually lose
their transparency if allowed to dry slowly in the air, becoming at
the same time harder and somewhat granular. This alteration is due
to the incorporation of water, which at last is not only mixed with
the components of the resinous juice, but to some extent combines
chemically with the resin so as to transform it into a crystalline body
having the characters of an acid. The fact is easily observed if clear
drops of the turpentine of _Pinus silvestris_, _P. Abies_ or _P. Picea_
are collected in vials and kept perfectly dry. Thus treated these
turpentines remain transparent, but the addition of water causes after
a short time the formation of microscopic crystals of abietic acid,
rendering them more or less opaque.

If turpentines are collected before they lose their essential oil by
evaporation and oxidation, and before they have become crystalline,
they can be retained perfectly transparent by distilling off the
volatile oil without water. The distillation being most commonly
carried on _with water_, the remaining resin is opaque.

Maly is of opinion that the same amorphous resin occurs in all the
_Coniferæ_, and that it yields by hydration the same acid, namely
_Abietic_, which has been described by former chemists as _Pinic_,
_Silvic_, and _Pimaric_ acids, all of which indeed are admitted to
have the same composition. We must however remember that several sorts
of turpentine, as Canada Balsam, appear incapable, according to our
experiments, of yielding any crystalline resinoid compound whatever;
and that their amorphous resin being but partially soluble is certainly
not a homogeneous substance.

The crystals as formed naturally in the common turpentines do not
exhibit precisely the same forms as those obtained artificially
when the resins are agitated with warm diluted alcohol, as in the
preparation of abietic acid. As to _Pimaric Acid_, we have prepared it
in quantity from _galipot_, the resin of _Pinus Pinaster_, but have
always found its crystalline character entirely different from that of
abietic acid.[2311]

[2311] _Jahresbericht_ of Wiggers and Husemann for 1867. 37.

We are inclined, therefore, to think that the composition of the resins
of _Coniferæ_ is not so uniform as Maly suggests. The remarkable
variety of their essential oils is a fact which seems in favour of our
view.

=Uses=—Burgundy pitch is prescribed as an ingredient of plasters, and
thus employed is useful as a mild stimulant. In Germany it has some
economic applications, one of which is the lining of beer casks, for
which purpose a composition is used called _Brauerpech_ (brewers’
pitch), made by mixing it with colophony or _galipot_.

=Adulteration=—No drug is the subject of more adulteration than
Burgundy pitch, so much so that the very name is understood by some
pharmacologists to be that of a manufactured compound. The substance
commonly sold in England is made by melting together colophony
with palm oil or some other fat, water being stirred in to render
the mixture opaque. In appearance it is very variable, different
samples presenting different shades of bright or dull yellow or
yellowish-brown. Many when broken exhibit numerous cavities containing
air or water; all are more or less opaque, becoming in time transparent
on the surface by the loss of water. Artificial Burgundy pitch is
offered for sale in bladders; it has a weak terebinthinous odour, and
is devoid of the peculiar fragrance of the genuine. The presence of a
fatty oil is easily discovered by treatment with double its weight of
glacial acetic acid, which forms a turbid mixture, separating by repose
into two layers, the upper being oily.


PIX LIQUIDA.

_Wood-Tar_; F. _Goudron végétal_, _Poix liquide_; G. _Holztheer_,
_Fichtentheer_.

=Botanical Origin=—Tar is obtained by submitting the wood of the stems
and roots of coniferous trees to dry or destructive distillation. That
found in commerce is produced in Northern Europe, chiefly from two
species, namely _Pinus silvestris_ L. and _P. Ledebourii_ Endl. (_Larix
sibirica_ Ledeb.). These trees constitute the vast forests of Arctic
Europe and Asia.

=History=—Theophrastus gives a circumstantial description of the
preparation of tar, which applies with considerable accuracy to the
processes still practised in those districts where no improved methods
of manufacture have yet been introduced.

=Production=—The great bulk of the vegetable tar used in Europe, and
known in commerce as _Archangel_ or _Stockholm Tar_, is prepared in
Finland, Central and Northern Russia, and Sweden.

The process is conducted in the following manner:—vast stacks of
pine wood consisting chiefly of the roots and lower portions of the
trunks (the more valuable parts of the trees being used as timber),
and containing as much as 30,000 to 70,000 cubic feet, are carefully
packed together, and then covered with a thick layer of turf, moss, and
earth, beaten down with heavy stampers. The whole stack of billets is
constructed over a conical or funnel-like cavity made in the ground,
if possible on the side of a hill, this arrangement being adopted for
the purpose of carrying on a downward distillation. Fire being applied
the combustion of the mass of wood has to be carried on very slowly and
without flame in order to obtain the due amount of tar and a charcoal
of good quality. During its progress the products, chiefly tar, collect
in the funnel-like cavity, from which they are discharged by a tube
into a cast-iron pan placed beneath the stack, or simply into hollow
tree trunks. The time required for combustion varies from one to four
weeks, according to the size of the stack.

During the last few years this rude process has been improved and
accelerated by the introduction of rationally constructed wrought-iron
stills, furnished with refrigerating condensers, as proposed in Russia
by Hessel in 1861. By this mode of manufacture the yield in tar of
pine wood is about 14 per cent. from stems, dried by exposure to the
open air; and 16 to 20 per cent. from roots. Large quantities of
pyroligneous acid and oil of turpentine are at the same time secured.
The wood of the beech and of other non-coniferous trees appears not to
afford more than 10 per cent. of tar, while turf yields only from 3 to
9 per cent.

=Description=—The numerous empyreumatic products which result from
the destructive distillation of pine wood, and which we call tar,
constitute a dark brown or blackish semi-liquid substance, of peculiar
odour and sharp taste. When deprived of water and seen in thin layers,
tar is perfectly transparent. The magnifying glass shows some of the
varieties to contain colourless crystals of _Pyrocatechin_, scattered
throughout the dark viscid substance, and to these tar owes its
occasionally granular, honey-like consistence.[2312] A gentle heat
causes them to melt and mix with the other constituents.

[2312] _Jahresbericht_ of Wiggers and Husemann for 1867. 37.

True vegetable tar has always a decidedly acid reaction. It is readily
miscible with alcohol, glacial acetic acid, ether, fixed and volatile
oils, chloroform, benzol, amylic alcohol or acetone. It is soluble in
caustic alkaline solutions, but not in pure water or watery liquids.
The sp. gr. of tar from the roots of conifers is about 1·06 (Hessel)
yet at a somewhat elevated temperature, it becomes lighter than warm
water.

Water agitated with tar acquires a light yellowish tint, and the taste
and odour of tar, as well as an acid reaction. On evaporation the
solution becomes brown, and at last microscopic crystals are obtained
with a brown residue like tar itself, which is no longer soluble in
water. A microscopical examination of tar which has been exhausted with
water, shows that all crystals have disappeared.

=Chemical Composition=—Dry wood may be heated to about 150° C. without
decomposition; but at a more elevated temperature, it commences to
undergo a change, yielding a large number of products, the nature and
comparative quantity of which depend upon circumstances. If the process
is carried on in a closed vessel, a residue will be got which has more
or less resemblance to coal. By heating fir-wood enclosed with some
water to 400° C., Daubrée (1857) obtained a coal-like substance, which
yielded by a subsequent increase of temperature scarcely any volatile
products.

The results are widely different if a process is followed which permits
the formation of volatile bodies; and these substances are formed in
largest proportion, if the heat acts quickly and intensely. At lower
degrees of heat, more charcoal results and more water is evolved.

Among the volatile products of destructive distillation, those alone
which are condensed at the ordinary temperature of the air are of
pharmaceutical interest; and of these, chiefly the portion not soluble
in water, or that which is called _Tar_ or _Liquid Pitch_. The aqueous
portion of the products consist principally of empyreumatic acetic
acid, to which tar owes its acid reaction.

The tissue of wood is chiefly formed of cellulose, intimately combined
with a saccharine substance, which may be separated if the wood is
boiled with dilute acids. The remaining cellulose is however not
yet pure, but is still united to a substance which, as shown by
Erdmann,[2313] is capable of yielding pyrocatechin.

[2313] Liebig, _Annalen der Chemie u. Pharmacie_, Suppl. v. (1867) 229.

It is well known that sugar subjected to an elevated temperature,
yields a series of pyrogenous products; and the same fact is observed
if purified cellulose is heated in similar manner. But for tar-making,
wood is preferred which is impregnated with resins and essential oils,
and these latter furnish another series of empyreumatic products.
From these circumstances, the components of wood-tar are of an
extremely complicated character, which is still more the case when
other woods than those of conifers form part of the material submitted
to distillation. In the case of beech-wood, _Creasote_ is formed,
which is obtained only in very small quantity from the _Coniferæ_.
Volatile alkaloids and carbolic acid, which are largely produced in the
destructive distillation of coal, appear not to be present in wood-tar.

The components of the latter may be considered under two heads:—first,
the _lighter aqueous portion_, which separates from the other products
of distillation, forming what is called _Impure Pyroligneous Acid_.
This contains chiefly acetic acid and _Methyl Alcohol_ or _Wood
Naphtha_, CH₄O; _Acetone_, C₃H₆O; besides other liquid products
abundantly soluble in water and acetic acid. In this portion, some
pyrocatechin also occurs.

The second class of pyrogenous products of wood consists of a
homologous series of liquid hydrocarbons, sparingly soluble in water,
and which therefore are chiefly retained in the heavy layer below the
pyroligneous acid, forming the proper wood-tar. The liquid in question
furnishes _Toluol_ or _Toluene_, C₇H₈ (boiling point 114° C.), _Xylole_
C₈H₁₀, and several other analogous substances.

If tar is redistilled, an elevated temperature being used towards the
end of the process, some crystallizable solid bodies are obtained, the
most important of which is that called _Paraffin_, having the formula
CₙH₍₂ₙ₊₂₎, _n_ varying from 20 to 24.

The crystals already mentioned as occurring in tar are _Pyrocatechin_.
They are easily sublimed at some degrees above their fusing point (104°
C.), or removed by acetic acid, in which as well as in water they are
readily soluble. Hence in some sorts of tar this substance does not
occur, it having probably been removed by water.

Pyrocatechin, C₆H₄(OH)₂, can be obtained by the destructive
distillation of many other substances, as catechu, kino, the extracts
of rhatany and bearberry leaves, and other extracts rich in that form
of tannin which produces _greenish_ (not _blue-black_) precipitates in
salts of iron. It is extracted from the granular sorts of wood-tar,
by exposing them at a proper temperature to a current of heated dry
air, or by exhausting them with water. Ether when shaken with the
concentrated aqueous solution and left to evaporate, leaves colourless
crystals of pyrocatechin which after purification are devoid of acid
reaction. They have a peculiar burning persistent taste, and are
very pungent and irritating when allowed to evaporate. A solution of
pyrocatechin yields with perchloride of iron a dark green coloration
changing to black after a few moments, and becoming red on the addition
of potash. This mixture finally acquires a magnificent violet hue, like
a solution of alkaline permanganate. No alteration is produced in a
solution of pyrocatechin by protosalts of iron.

Among the few medicinal preparations of tar, is _Tar Water_, called
_Aqua vel Liquor Picis_, made by agitating wood-tar with water. The
presence in it of pyrocatechin is easily proved by the above-mentioned
reactions, or by a few drops of red chromate of potassium, which
produces a brownish black colouration. It may hence be inferred that
pyrocatechin is perhaps the active ingredient in tar-water, and that
for making this liquid the granular, crystalline sorts of tar should be
preferred.[2314]

=Commerce=—Tar as well as pitch is manufactured in Finland, and shipped
from various ports in the Gulf of Bothnia, as Uleaborg, Gamla Carleby,
Jacobstad, Ny Carleby and Christinestad; also from Archangel and Onega
on the White Sea. Some tar is also produced in Volhynia, and finds its
way by the Dnieper to the Black Sea.

The North of Sweden likewise produces tar, chiefly about Umea and
Lulea, the distillation being now performed in well-constructed
apparatus of iron.

The pine forests of North America afford tar and pitch. Wilmington
in North Carolina exported in 1871, 25,260 barrels of tar, and 3788
barrels of pitch.[2315]

[2314] We may suppose that the authors of the French _Codex_ were not
of this opinion, inasmuch as in making _Eau de Goudron_, they order
that the liquid obtained by the first maceration of the tar, shall be
thrown away.

[2315] Consul Walker, _Report on the Trade of North and South
Carolina—Consular Reports_ presented to Parliament, May, 1872.

The imports of tar into the United Kingdom in 1872, were 189,291
barrels, valued at £218,339. Of this quantity 145,483 barrels were
shipped from the northern ports of Russia.

The barrels in which tar arrives hold about 30 gallons. Smaller sized
vessels termed _half-barrels_ are also used, though less frequently.

=Uses=—In medicine of no great importance: an ointment of tar is
a common remedy in cutaneous diseases, and tar water is sometimes
taken internally. The consumption of tar in shipbuilding and for the
preservation of fences, sufficiently explains the large importations.

Other Varieties of Tar.

_Juniper Tar_, _Pyroleum Oxycedri_, _Oleum Juniperi empyreumaticum_,
_Oleum Cadinum_, _Huile de Cade_.—This is a tar originally obtained
by the destructive distillation of the wood of the _Cade_, _Juniperus
Oxycedrus_ L., a shrub or small tree, native of the countries bordering
the Mediterranean. It was for centuries used in the South of France as
an external remedy, chiefly for domestic animals, but had fallen into
complete oblivion until ten years ago, when it began to be prescribed
in skin complaints.

The _Huile de Cade_ now in use, is transparent and devoid of crystals.
It is somewhat thinner than Swedish tar, but closely agrees with it in
other respects. It is imported from the Continent, but where made and
from what wood we know not. _Huile de Cade_ is mentioned by Olivier de
Serres,[2316] a celebrated French writer on agriculture of the 16th
century; it is named by Parkinson[2317] in 1640; also by Pomet,[2318]
in whose time (1694) it was rarely genuine, common tar being sold in
its place.

[2316] _Théâtre d’Agriculture_, Paris, 1600. 941.

[2317] _Theatrum Botanicum_, 1033.

[2318] _Hist. des Drogues_, Paris, 1694. part i. chap. xii. xiv.

_Beech Tar_—Tar is also manufactured from the wood of the beech, _Fagus
silvatica_ L., and has a place in some pharmacopœias as the best source
of creasote.

_Birch Tar_—is made to a small extent in Russia, where it is called
_Dagget_, from the wood of _Betula alba_ L. It contains an abundance
of pyrocatechin, and is esteemed on account of its peculiar odour well
known in the Russia leather. A purified oil of birch tar is sold by the
Leipzig distillers.


PIX NIGRA.

_Pix sicca vel solida vel navalis_; _Pitch_, _Black Pitch_; F. _Poix
noire_; G. _Schiffspech_, _Schusterpech_, _Schwarzes Pech_.

=Botanical Origin=—see _Pix liquida_.

=Production=—When the crude products of the dry distillation of
pine wood, as described in the previous article, are submitted to
re-distillation, the following results are obtained. The first 10 to
15 per cent. of volatile matter consists chiefly of methylic alcohol
and acetone. A higher temperature causes the vaporization of the
acetic acid, while the still retains the tar. This last, subjected
to a further distillation, may be separated into a liquid portion
called _Oil of Tar_ (_Oleum Picis liquidæ_), and a residuum which,
on cooling, hardens and forms the product under notice, namely _Black
Pitch_. Again heated to a very elevated temperature, it is capable of
yielding paraffin, anthracene and naphthalene.

=Description=—Pitch is an opaque-looking, black substance, breaking
with a shining conchoidal fracture, the fragments showing at the
thin translucent edges a brownish colour. No trace of distinct
crystallization is observable when very thin fragments are examined,
even by polarized light. Pitch has a peculiar disagreeable odour,
rather different from that of tar. Its alcoholic solution has a feeble
taste somewhat like that of tar, but pitch itself when masticated is
almost tasteless. It softens by the warmth of the hand, and may then
be kneaded. It readily dissolves in those liquids which are solvents
of tar. Alcohol of 75 per cent. acts freely on it, leaving behind in
small proportion a dark viscid residue. The brown solution reddens
litmus paper, and yields a dingy brownish precipitate with perchloride
of iron, and whitish precipitates with alcoholic solution of neutral
acetate of lead, or with pure water. Pitch dissolves in solution of
caustic potash, evolving an offensive odour.

=Chemical Composition=—From the method in which pitch is prepared,
we may infer that it contains some of the less volatile and less
crystallizable compounds found in tar. Ekstrand (1875) extracted from
it _Retene_, C₁₈H₁₈, a colourless, inodorous crystalline substance,
melting at 90° C.

The pitch of beech-wood boiled with a caustic alkali, yields a fœtid
volatile oil; when this solution is acidulated, fatty volatile acids
are evolved. These principles however have not yet been isolated either
from the pitch of pine or beech. The whitish compound formed by acetate
of lead in an alcoholic solution of pitch deserves investigation, and
perhaps might be the starting point for acquiring a better knowledge of
the chemistry of this substance.

=Commerce=—The same countries that produce tar produce also pitch. The
quantity of the latter imported into the United Kingdom during 1872 was
35,482 cwt., four-fifths of which were supplied by Russia. Pitch is
also manufactured from tar in Great Britain.

=Uses=—Pitch is occasionally administered in the form of pills, or
externally as an ointment; but its medicinal properties are, to say the
least, very questionable.


FRUCTUS JUNIPERI.

_Baccæ Galbuli Juniperi_; _Juniper Berries_; F. _Baies de Genièvre_; G.
_Wacholderbeeren_, _Kaddigbeeren_.

=Botanical Origin=—_Juniperis communis_ L., a diœcious evergreen,
occurring in Europe from the Mediterranean to the Arctic regions,
throughout Russian Asia as far as Sachalin, and in the north-western
Himalaya, where it is ascending in Kashmir at 5400 feet, in Lahoul to
12,500, on the upper Biās and in Gurhwal to 14,000 feet. It abounds
in the islands of Newfoundland, Saint Pierre, and Miquelon, and is
also found in Continental North America. Dispersed over this vast area
the Common Juniper presents several varieties. In England and in the
greater part of Europe it forms a bushy shrub from 2 to 6 feet high,
but in the interior of Norway and Sweden it becomes a small forest tree
of 30 to 36 feet, often attaining an age of hundreds of years.[2319] In
high mountain regions of temperate Europe and in Arctic countries it
assumes a decumbent habit (_Juniperus nana_ Willd.), rising only a few
inches above the soil.

=History=—The fruits of Juniper, though by no means exclusively those
of _J. communis_, were commonly used in medicine by the Greek and Roman
as well as by the Arabian physicians; they had a place among the drugs
of the Welsh “physicians of Myddvai” (see Appendix), and are mentioned
in some of the earliest printed herbals. The oil was distilled by
Schnellenberg[2320] as early as 1546.

Popular uses were formerly assigned in various parts of Europe to
Juniper berries. They were employed as a spice to food;[2321] and a
spirit, of which wormwood was an ingredient, was obtained from them by
fermentation and distillation. The spirit called in French _Genièvre_
became known in English as _Geneva_, a name subsequently contracted
into _Gin_.[2322]

[2319] Schübeler, _Culturpflanzen Norwegens_, Christiania, 1873-1875.
140, with fig.

[2320] _Artsneybuch_, Königsberg, 1556. 35.

[2321] Valmont de Bomare, _Dict. d’Hist. nat._ ii. (1775) 45.

[2322] The gin distilled in Holland is flavoured with Juniper berries,
yet, as we are told, but very slightly, only 2 lb. being used to 100
gallons.

=Description=—The flowers form minute axillary catkins; those of the
female plant consist of 3 to 5 whorls of imbricated bracts. Of these
the uppermost three soon become fleshy and scale-like, and alternate
with three upright ovules having an open pore at the apex. After the
flowers have faded these three fleshy bracts grow together to form a
berry-like fruit termed a _galbulus_, which encloses three seeds. The
three points and sutures of the fruit-scales are conspicuous in the
upper part of the young fruit; but after maturity the sutures alone
are visible, forming a depressed mark at its summit. A small point,
surrounded by two or three trios of minute bracts, indicates the base
of the fruit.

This fruit or pseudo-berry remains ovate and green during its first
year, and it is not until the second autumn that it becomes ripe. It is
then spherical, ³/₁₀ to ⁴/₁₀ of an inch in diameter, of a deep purplish
colour, with a blue-grey bloom. Its internal structure may be thus
described:—beneath the thin epicarp there is a loose yellowish-brown
sarcocarp, enclosing large cavities, the oil-ducts; the three hard
seeds lying close together, triangular and sharp-edged at the top, are
attached to the sarcocarp at their outer sides, and only as far as
the lower half. The upper half, which is free, is covered by a thin
membrane. In the longitudinal furrows of the hard testa towards the
lower half of the seed are small prominent sacs growing out into the
sarcocarp. Each seed bears on its inner side 1 or 2, and on its convex
outer surface 4 to 8 of these sacs, which in old fruits contain the
resinified oil in an amorphous colourless state.

Juniper berries when crushed have an aromatic odour, and a spicy,
sweetish, terebinthinous taste.

=Microscopic Structure=—The outer layer of the fruit consists of a
colourless transparent cuticle, which covers a few rows of large cubic
or tabular cells having thick, brown, porous walls. These cells contain
a dark granular substance and masses of resin. The sarcocarp, which
in the ripe state consists of large, elliptic, thin-walled, loosely
coherent cells, contains chlorophyll, drops of essential oil, and a
crystalline substance soluble in alcohol,—no doubt a stearoptene.
Before maturity it likewise contains starch granules and large
oil-cells. This tissue is traversed by very small vascular bundles
containing annulated and dotted vessels.

=Chemical Composition=—The most important constituent of juniper
berries is the volatile oil, obtainable to the extent of 0·4 to 1·2 per
cent. The latter amount is obtained from Hungarian, 0·7 per cent. from
German fruits.[2323] It is a mixture of levogyre oils, the one of which
having the composition C₁₀H₁₆ boils at 155° C.; the prevailing portion
of the oil, boiling at about 200°, consists of hydrocarbons, which
are polymeric with terpene, C₁₀H₁₆. The crude oil as distilled by us
deviated 3°·5 to the left in a column of 50 mm.

[2323] According to Messrs. Schimmel & Co. (see p. 306, note 2.)

By passing nitrosyl chloride gas, NOCl, into it, Tilden (1877)
obtained from the portion boiling below 160° the crystallized compound
C₁₀H₁₆(NOCl), which is yielded by all the terpenes.

Another important constituent of juniper berries is the glucose, of
which Trommsdorff (1822) obtained 33 per cent., while Donath (1873)
found 41·9, and Ritthausen (1877) not more than 16 per cent. in the
berries deprived of water. Of albuminoid substances about 5 per cent.
are present, of inorganic matters 3 to 4 per cent. The fruit, moreover,
contains also according to Donath small amounts of formic, acetic, and
malic acids, besides resin.

=Collection and Commerce=—Juniper berries are largely collected in
Savoy, and in the departments of the Doubs and Jura in France, whence
they find their way to the hands of the Geneva druggists. They are
also gathered in Austria, the South of France and Italy. In Hamburg
price-currents they are quoted as _German_ and _Italian_. The largest
supplies are apparently furnished by Hungaria.

=Uses=—The berries and the essential oil obtained from them are reputed
diuretic, yet are not often prescribed in English medicine.


HERBA SABINÆ.

_Cacumina vel Summitates Sabinæ_; _Savin or Savine_; F. _Sabine_; G.
_Sevenkraut_.

=Botanical Origin=—_Juniperus Sabina_ L., a woody evergreen shrub,
usually of small size and low-growing, spreading habit, but in some
localities erect and arborescent.

It occurs in the Southern Alps of Austria (Tirol) and Switzerland (Visp
or Viège and Stalden in the Valais, also in Grisons and Vaud), and in
the adjacent mountains of France and Piedmont, ascending to elevations
of 4,000 to 5,000 feet. It is also found in the Pyrenees, Central
Spain, Italy and the Crimea; likewise in the Caucasus, where it reaches
12,000 feet above the sea-level. Eastward it extends to the Elburs
range, south of the Caspian, and throughout Southern Siberia, where it
ascends in the Balkhasch and Alatau mountains to 8,600 feet. In North
America it has been gathered on the banks of the river Saskatchewan, at
Lake Huron, in Newfoundland, and in Saint Pierre and Miquelon. There
are, however, a few very closely allied species which may occasionally
have been confounded with savin.

=History=—Savin is mentioned as a veterinary drug by Marcus Porcius
Cato,[2324] a Roman writer on husbandry who flourished in the second
century B.C.; and it was well known to Dioscorides (under the name of
βρἀθυ) and Pliny. The plant, which is frequently named in the early
English leech-books written before the Norman Conquest,[2325] may
probably have been introduced into Britain by the Romans. Charlemagne,
A.D. 812, ordered that it should be cultivated on the imperial farms of
Central Europe. Its virtues as a stimulating application to wounds and
ulcers are noticed in the verses of Macer Floridus,[2326] composed in
the 10th century.

=Description=—The medicinal part of savin is the young and tender green
shoots, stripped from the more woody twigs and branches. These are
clothed with minute scale-like rhomboid leaves, arranged alternately in
opposite pairs. On the younger twigs they are closely adpressed, thick,
concave, rounded on the back, in the middle of which is a conspicuous
depressed oil gland. As the shoots grow older the leaves become more
pointed and divergent from the stem. Savin evolves, when rubbed or
bruised, a strong and not disagreeable odour. The blackish fruit or
_galbulus_ resembling a small berry, ²/₁₀ of an inch in diameter,
grows on a short recurved stalk, and is covered with a blue bloom. It
is globular, dry, but abounding in essential oil, and contains 1 to 4
little bony nuts.

To mycologists, _Juniperus Sabina_, at least in the cultivated state,
is interesting on account of the parasitic fungus _Podisoma fuscum_
Duby, the mycelium of which produces, on the leaves of the pear-trees,
the so-called _Roestelia cancellata_ Rebentisch.

=Chemistry=—The odour of savin is due to an essential oil, of which
the fresh tops afford 2 to 4 per cent., and the berries about 10 per
cent. Examined in a column 50 millimetres long it was found to deviate
the ray of polarized light 27° to the right, the oil used having been
distilled by one of us in London from the fresh plant cultivated at
Mitcham. The same result was obtained from the oil abstracted ten years
previously from savin collected wild on the Alps of the Canton de Vaud,
Switzerland. We find that, by the prolonged action of the air, if
the oil is kept in a vessel not carefully closed, the rotatory power
after the lapse of years is greatly reduced. Savin oil, according to
Tilden (1877), yields a small amount of an oil boiling at 160°, which
answers to the formula C₁₀H₁₆O. The greater part of the oil was found
by that chemist to boil above 200° C. Tilden asserts that no terpene is
present in the oil of savin; we have not been able to obtain from it a
crystallized hydrochloride. Savin tops contain traces of tannic matter.

[2324] Cap. lxx. (_Bubus medicamentum_).

[2325] Cockayne, _Leechdoms, etc., of Early England_, ii. (1865) xii.

[2326] Choulant, _Macer Floridus de viribus herbarum_, Lipsiæ,
1832. 48.... “Duplum si desunt _cinnama_ poni in medicamentis iubet
_Oribasius_ auctor.”

=Uses=—Savin is a powerful uterine stimulant, producing in overdoses
very serious effects. It is but rarely administered internally. An
ointment of savin, which from the chlorophyll it contains is of a fine
green colour, is used as a stimulating dressing for blisters.

=Substitutes=—There are several species of juniper which have a
considerable resemblance to savin; and one of them, commonly grown
in gardens and shrubberies, is sometimes mistaken for it. This is
_Juniperus virginiana_ L., the _Red Cedar_ or _Savin_ of North America.
In its native country it is a tree, attaining a height of 50 feet
or more, but in Britain it is seldom more than a large shrub, of
loose spreading growth, very different from the low, compact habit
of savin.[2327] The foliage is of two sorts, consisting either of
minute, scale-like, rhomboid leaves like those of savin, more rarely
of elongated, sharp, divergent leaves a quarter of an inch in length,
resembling those of common Juniper. Both forms often occur on the
same branch. The plant is much less rich in essential oil than true
savin,[2328] for which it is sometimes substituted in the United States.

The foliage of _Juniperus phœnicea_ L., a Mediterranean species,
has some resemblance to savin for which it is said to be sometimes
substituted,[2329] but it is quite destitute of the peculiar odour of
the latter. The specific name of the former alludes to its _red_ fruit,
from ϕοινίκιος, purple.

[2327] We have examined numerous herbarium specimens (wild) of _J.
virginiana_ and _J. Sabina_, but except difference of stature and
habit, can observe scarcely any characters for separating them as
species. The fruit-stalk in _J. virginiana_ is often pendulous as in
_J. Sabina_. Each plant has two forms,—arboreous and fruticose.

[2328] This we ascertained by distilling under precisely similar
conditions 6 lbs. 6 oz. of the fresh shoots of each of the two plants,
_Juniperus Sabina_ and _J. virginiana_: the first gave 9 drachms of
essential oil, the second only ½ a drachm. The latter was of a distinct
and more feeble odour, and a different dextrogyre power. In America
the oil of _J. virginiana_ is known as “_Cedar Oil_,” and used as a
taenifuge. It contains a crystallizable oxygenated portion. This oil
however is afforded by the wood. Red Cedar wood from Florida is stated
by Messrs. Schimmel & Co. (see p. 306) to afford as much as 4 to 5 per
cent. of that oil.

[2329] _Bonplandia_, x. (1862) 55.




_Monocotyledons._




CANNACEÆ.


AMYLUM MARANTÆ.

_Arrowroot._

=Botanical Origin=—_Maranta arundinacea_[2330] L.—An herbaceous
branching plant, 4 to 6 feet high, with ovate-lanceolate, puberulous
or nearly glabrous leaves, and small white flowers, solitary or in lax
racemes. It is a native of the tropical parts of America from Mexico
to Brazil, and of the West Indian Islands; and under the slightly
different form known as _M. indica_ Tussac, it occurs in Bengal,
Java and the Philippines. This Asiatic variety is now found in the
West Indies and Tropical America, but apparently as an introduced
plant.[2331]

=History=—The history of arrowroot is comparatively recent. Passing
over some early references of French writers on the West Indies to an
_Herbe aux flèches_, which plant it is impossible to identify with
_Maranta_, we find in Sloane’s catalogue of Jamaica plants (1696),
_Canna Indica radice alba alexipharmaca_. This plant, discovered in
Dominica, was sent thence to Barbadoes and subsequently to Jamaica,
it being, says Sloane, “_very much esteemed for its alexipharmack
qualities_.” It was observed, he adds, that the native Indians used the
root of the plant with success against the poison of their arrows, “_by
only mashing and applying it to the poison’d wounds_”: and further,
that it cures the poison of the manchineel (_Hippomane Mancinella_ L.),
of the wasps of Guadaloupe, and even stops “_a begun gangreen_.”[2332]

[2330] Fig. in Bentley and Trimen’s _Med. Plants_, part 23 (1877).

[2331] We accept the opinion of Körnicke (_Monographiæ Marantaccarum
Prodromus, Bull. de la Soc. imp. des Naturalistes de Moscou_, xxxv.
1862, i.) that _Maranta arundinacea_ L. and _M. indica_ Tuss. are one
and the same species. Grisebach maintains them as distinct (_Flora
of the British West Indian Islands_, 1864, 605), allowing both to be
natives of Tropical America; but he fails to point out any important
character by which they may be distinguished from each other. According
to Miquel (_Linnæa_, xviii. 1844. 71) the plant in the herbarium of
Linnæus labelled _M. arundinacea_, is _M. indica_. We have ourselves
made arrowroot from the fresh rhizomes of _M. arundinacea_, in order
to compare it with an authentic specimen obtained in Java from _M.
indica_: no difference could be found between them.

[2332] Sloane, _Catal. plant. quæ in ins. Jamaica sponte proveniunt,
vel vulgò coluntur_, Lond. 1696. 122; also _Hist. of Jamaica_, i.
(1707) 253.

Patrick Browne (1756) notices the reputed alexipharmic virtues of
_Maranta_, which was then cultivated in many gardens in Jamaica,
and says that the root “_washed, pounded fine and bleached, makes a
fine flour and starch_”—sometimes used as food when provisions are
scarce.[2333]

Hughes, when writing of Barbadoes in 1750, describes arrowroot as a
very useful plant, the juice mixed with water and drunk being regarded
as “_a preservative against any poison of an hot nature_”; while from
the root the finest starch is made, far excelling that of wheat.[2334]
The properties of _Maranta arundinacea_ as a counter-poison are
insisted upon at some length by Lunan,[2335] who concludes his notice
of the plant by detailing the process for extracting starch from the
rhizome.

Arrowroot came into use in England about the commencement of the
present century, the supplies being obtained, as it would appear, from
Jamaica.[2336]

The statements of Sloane, which are confirmed by Browne and Lunan,
plainly indicate the origin and meaning of the word _arrowroot_, and
disprove the notion of the learned C. F. Ph. von Martius (1867) that
the name is derived from that of the Arnac or Aroaquis Indians of
South America, who call the finest sort of fecula they obtain from
the Mandioc _Aru-aru_. It is true that _Maranta arundinacea_ is known
at the present day in Brazil as _Araruta_, but the name is certainly
a corruption of the English word _arrowroot_, the plant according to
general report having been introduced.[2337]

=Manufacture=—For the production of arrowroot, the rhizomes are dug up
after the plant has attained its complete maturity, which in Georgia
is at the beginning of winter. The scales which cover them are removed
and the rhizomes washed; the latter are then ground in a mill, and
the pulp is washed on sieves, or in washing machines constructed for
the purpose, in order to remove from it the starch. This is allowed
to settle down in pure water, is then drained and finally dried with
a gentle heat. Instead of being crushed in a mill, the rhizomes are
sometimes grated to a pulp by a rasping machine.

In all stages of the process for making arrowroot, nice precautions
have to be taken to avoid contamination with dust, iron mould, insects,
or anything which can impart colour or taste to the product. The
rhizome contains about 68 per cent. of water, and yields about a fifth
of its weight of starch.[2338]

[2333] _Civil and Natural History of Jamaica_, 1756. 112. 113.

[2334] _Natural History of Barbados_, 1750. 221.

[2335] _Hortus Jamaicensis_, i. (1814) 30.

[2336] Thus in 1799 there were exported from Jamaica 24 casks and boxes
of “_Indian Arrowroot_.”—Renny, _Hist. of Jamaica_, 235.

[2337] Since the above was written, the following lines bearing on
this question have been received from Mr. Spruce:—“ ... I know not
Martius’ derivation of ‘_arrowroot_.’ On the Amazon it is called
‘_ararúta_’—plainly a corruption of the English name, and explained
by the fact that it was first cultivated, as I was told, from tubers
obtained in the East Indies.”

[2338] This was in the German colony of Blumenau in Southern
Brazil—Eberhard, _Arch. der Pharm._ 134 (1868) 257.

=Description=—Arrowroot is a brilliant white, insipid, inodorous,
powder, more or less aggregated into lumps which seldom exceed a pea in
size; when pressed it emits a slight crackling sound. It exhibits the
general properties of starch, consisting entirely of granules which are
subspherical, or broadly and irregularly egg-shaped; when seen in water
they show a distinct stratification in the form of fine concentric
rings around a small star-like hilum. They have a diameter of 5 to 7
mkm. when observed in the air or under benzol. If the water in which
they lie be cautiously heated on the object-stage of the microscope,
the tumefaction of the granules will be found to begin exactly at
70° C. Heated to 100° C. with 20 parts of distilled water, arrowroot
yields a semi-transparent jelly of somewhat earthy taste and smell.
By hydrochloric acid of sp. gr. 1·06, arrowroot is but imperfectly
dissolved at 40° C.

The specific gravity of all varieties of starch is affected by the
water which they retain at the ordinary temperature of the air.
Arrowroot after prolonged exposure to an atmosphere of average
moisture, and then kept at 100° C. till its weight was constant, was
found to have lost 13·3 per cent. of water. On subsequent exposure to
the air, it regained its former proportion of water.

Weighed in any liquid which is entirely devoid of action on starch, as
petroleum or benzol, the sp. gr. of arrowroot was found by one of us to
be 1·504; but 1·565 when the powder had been previously dried at 100° C.

=Microscopic Structure of Arrowroot and of Starch in general=—The
granules are built up of layers,—a structure which may be rendered
evident by the gradual action of chloride of calcium, chromic acid, or
an ammoniacal solution of cupric oxide. When one of these liquids in a
proper state of dilution is made to act upon starch, or when for that
purpose a liquid is chosen which does not act upon it energetically,
such as diastase, bile, pepsin, or saliva, it is easy to obtain a
residue, which according to Nägeli, is no longer capable of swelling up
in boiling water, nor is immediately turned blue by iodine, except on
the addition of sulphuric acid; but which is dissolved by ammoniacal
cupric oxide. These are the essential properties of cellulose; and
this residue has been regarded as such by Nägeli, while the dissolved
portion has been distinguished as _Granulose_ (Maschke, 1852).

C. Nägeli in his important monograph on starch[2339] has described the
action of saliva when digested with starch for a day, at a temperature
of 40° to 47° C.; he says that the residue is a skeleton, corresponding
in form to the original grain but somewhat smaller, light, and very
mobile in water. He concludes that its interstitial spaces must have
been previously filled with granulose.

This experiment, which has been repeated by one of us (F.), does not in
our opinion warrant all the inferences that Nägeli has drawn from it:
it is true that many separate parts of the grain are dissolved by the
saliva, while others have disappeared down to a mere film, and others
again have been attacked in a very irregular manner. But we cannot
agree with the statement that anything comparable to a skeleton of
the grain has been left. After longer action at a higher temperature,
which however must not exceed 65° C., a more copious dissolution of the
starch, either by saliva or by bile, takes place; but in no case is it
complete.[2340]

[2339] _Die Stärkekörner_, Zürich, 1858. 4°, also W. Nägeli,
_Stärkegruppe_, etc., Leipzig, 1874.

[2340] Further particulars on this question may be found in my paper
_Ueber Stärke und Cellulose—Archiv der Pharmacie_, 196 (1871) 7.—F. A.
F.

=Chemistry of Starch=—Its composition answers to the formula
(C₆H₁₀O₅)₂+3 OH₂, or when dried at 100° C., C₆H₁₀O₅. Musculus however
showed, in 1861, that by the action of dilute acids or of _Diastase_,
starch is resolved into _Dextrin_, C₁₂H₂₀O₁₀, and _Dextrose_, C₆H₁₂O₆,
with which decomposition, the formula, C₁₈H₃₀O₁₅, would be more
in accord. Sachsse (1877) on the other hand advocates the formula
C₃₀H₆₂O₃₁ + 12 OH₂.

Cold water is not without action on starch; if the latter be
continuously triturated with it, the filtrate, in which no particles
can be detected by the microscope, will assume a blue colour on
addition of iodine, without the formation of a precipitate. The
proportion of starch thus brought into solution is infinitely small,
and always at the expense of the integrity of the grains. It is even
probable that the solution in this case is due to the minute amount of
heat, which must of necessity be developed by the trituration.

Certain reagents capable of attacking starch act upon it in very
different ways. The action in the cold of concentrated aqueous
solutions of easily soluble neutral salts or of chloral hydrate is
remarkable. Potassium bromide or iodide, or calcium chloride for
instance, cause the grains to swell, and render them soluble in cold
water. At a certain degree of dilution a perfectly clear liquid is
formed, which at first contains neither dextrin nor sugar; it is
coloured blue, but is not precipitated by iodine water; and starch can
be thrown down from it by alcohol. This precipitate, though entirely
devoid of the structural peculiarity of starch, still exhibits some
of the leading properties of that substance; it is coloured in the
same manner by iodine, does not dissolve even when fresh in ammoniacal
cupric oxide, and after drying is insoluble in water, whether cold or
boiling. The progress of the solvent is most easily traced when calcium
chloride is used, as this salt acts more slowly than the others we have
mentioned. It leaves scarcely any perceptible residue. This fact in
our opinion militates against the notion that starch is composed of a
peculiar amylaceous substance, deposited within a skeleton of cellulose.

The remarkable action of iodine upon starch was discovered in 1814 by
Colin and Gaultier de Claubry. It is extremely different in degree,
according to the peculiar kind of starch, the proportion of iodine, and
the nature of the substance the grains are impregnated with, before or
after their treatment with iodine. The action is even entirely arrested
(no blue colour being produced) by the presence in certain proportion
of quinine, tannin, _Aqua Picis_, and of other bodies.

The combination of iodine with starch does not take place in equivalent
proportions, and is moreover easily overcome by heat. The iodine
combined with starch amounts at the utmost to 7·5 per cent. The
compound is most readily formed in the presence of water, and then
produces a deep indigo-blue. Almost all other substances capable of
penetrating starch grains, weaken the colour of the iodine compound
to violet, reddish yellow, yellow, or greenish blue. These different
shades, the production of which has been described by Nägeli with great
diffuseness, are merely the colours which belong to iodine itself in
the solid, liquid, or gaseous form. They must be referred to the fact
that the particles of iodine diffuse themselves in a peculiar but
hitherto unexplained manner within the grain or in the swollen and
dissolved starch.

=Commerce of Arrowroot=—The chief kinds of arrowroot found in commerce
are known as _Bermuda_, _St. Vincent_, and _Natal_; but that of
Jamaica and other West India Islands, of Brazil, Sierra Leone, and the
East Indies, are quoted in price-currents, at least occasionally. Of
these the Bermuda enjoys the highest reputation and commands by far
the highest price; but its good quality is shared by the arrowroot
of other localities, from which, when equally pure, it can in nowise
be distinguished. Greenish,[2341] however, points out that in Natal
arrowroot the layers (or laminæ) are more obvious than in other
varieties, although it appears that the former is also produced by
Maranta.

The importations of arrowroot into the United Kingdom during the year
1870 amounted to 21,770 cwt., value £33,063. Of this quantity the
island of St. Vincent in the West Indies furnished nearly 17,000 cwt.,
and the colony of Natal about 3000 cwt. The exports from St. Vincent
in 1874 were 2,608,100 lb, those of the Bermudas in 1876 only 45,520
lb.[2342] The shipments from the colony of Natal during the years 1866
to 1876 varied from 1,076 cwt. in 1873 to 4,305 cwt. in 1867.[2343]

[2341] _Yearbook of Pharm._ (1875) 529.

[2342] Papers relating to H.M. Colonial Possessions. Reports for
1875-76. Presented to both Houses of Parliament, July 1877. 54. 4.

[2343] Statist. Abstr. for the several Colonial and other Possessions
of the United Kingdom, 14th number, 1878. p. 60.

=Uses=—Arrowroot boiled with water or milk is a much-valued food in
the sick-room. It is also an agreeable article of diet in the form of
pudding or blancmange.

=Adulteration=—Other starches than that of _Maranta_ are occasionally
sold under the name of _Arrowroot_. Their recognition is only possible
by the aid of the microscope.

Substitutes for Arrowroot.

_Potato Starch_—This substance, known in trade as _Farina_ or _Potato
Flour_, is made from the tubers of the potato (_Solanum tuberosum_
L.) by a process analogous to that followed in the preparation of
arrowroot. It has the following characters:—examined under the
microscope, the granules are seen to be chiefly of two sorts, the first
small and spherical, the second of much larger size, often 100 mkm. in
length, having an irregularly circular, oval or egg-shaped outline,
finely marked with concentric rings round a minute inconspicuous
hilum. When heated in water, the grains swell considerably even at
60° C. Hydrochloric acid, sp. gr. 1·06, dissolves them at 40° quickly
and almost completely, the granules being no longer deposited, as in
the case of arrowroot similarly treated. The mixture of arrowroot
and hydrochloric acid is inodorous, but that of potato starch has a
peculiar though not powerful odour.

_Canna Starch, Tous-les-Mois_,[2344] _Toulema, Tolomane_—A species of
_Canna_ is cultivated in the West India Islands, especially St. Kitts,
for the sake of a peculiar starch which, since about the year 1836,
has been extracted from its rhizomes by a process similar to that
adopted in making arrowroot. The specific name of the plant is still
undetermined; it is said to agree with _Canna edulis_ Ker (_C. indica_
Ruiz et Pavon).[2345]

[2344] It is commonly stated that the name _Tous-les-mois_ was given
in consequence of the plant flowering _all the year round_. But this
explanation appears improbable: no such name is mentioned by Rochefort,
Aublet, or Descourtilz, who all describe the _Balisier_ or _Canna_. It
seems more likely that the term is the result of an attempt to confer
a meaning on an ancient name—perhaps _Touloula_, which is one of the
Carib designations for _Canna_ and _Calathea_.

[2345] Fig. in Bentley and Trimen’s _Medic. Plants_, part 8 (1876).

The starch, which bears the same name as the plant, is a dull white
powder, having a peculiar satiny or lustrous aspect, by reason of the
extraordinary magnitude of the starch granules of which it is composed.
These granules examined under the microscope are seen to be flattened
and of irregular form, as circular, oval, oblong, or oval-truncate.
The centre of the numerous concentric rings with which each granule is
marked, is usually at one end rather than in the centre of a granule.
The hilum is inconspicuous. The granules though far larger than those
of the potato, are of the same density as the smaller forms of that
starch, and, like them, float perfectly on chloroform. When heated,
they begin to burst at 72° C. Dilute hydrochloric acid acts upon them
as it does on arrowroot.

Canna starch boiled with 20 times its weight of water affords a jelly
less clear and more tenacious than that of arrowroot, yet applicable
to exactly the same purposes. The starch is but little known and not
much esteemed in Europe; it was exported in 1876 from St. Kitts to the
amount of 51,873 lb, besides 5,300 lb arrowroot starch.[2346]

_Curcuma Starch, Tikor_—The pendulous, colourless tubers of some
species of _Curcuma_, but especially of _C. angustifolia_ Roxb. and
_C. leucorrhiza_ Roxb., have long been utilized in Southern India
for the preparation of a sort of arrowroot, known by the Hindustani
name of _Tikor_, or _Tikhur_, and sometimes called by Europeans _East
Indian Arrowroot_.[2347] The granules of this substance much resemble
those of _Maranta_, but they are neither spherical nor egg-shaped.
On the contrary, they are rather to be described as flat discs, 5 to
7 mkm. thick, of elliptic or ovoid outline, sometimes truncate; many
attain a length of 60 to 70 mkm. They are always beautifully stratified
both on the face and on the edge. The hilum is generally situated at
the narrower end. We have observed that when heated in water, the
tumefaction of the grains commences at 72° C.

Curcuma starch, which in its general properties agrees with common
arrowroot, is rather extensively manufactured in Travancore, Cochin and
Canara on the south-western coast of India, but in a very rude manner.
Drury[2348] states that it is a favourite article of diet among the
natives, and that it is exported from Travancore and Madras; we can
add that it is not known as a special kind in the English market, and
that the article we have seen offered in the London drug sales as _East
Indian Arrowroot_ was the starch of _Maranta_.

[2346] Page 102 of the Reports quoted at p. 633, note 2.

[2347] Living roots of the plant used for making this arrowroot at
Cochin, have been kindly forwarded to us by A. F. Sealy, Esq. of that
place.

[2348] _Useful Plants of India_, ed. 2. 1873. 168.




ZINGIBERACEÆ.


RHIZOMA ZINGIBERIS.

_Radix Zingiberis_; _Ginger_; F. _Gingembre_; G. _Ingwer_.

=Botanical Origin=—_Zingiber officinale_ Roscoe (_Amomum Zingiber_
L.), a reed-like plant, with annual leafy stems, 3 to 4 feet high, and
flowers in cone-shaped spikes borne on other stems thrown up from the
rhizome. It is a native of Asia, in the warmer countries of which it
is universally cultivated,[2349] but not known in a wild state. It has
been introduced into most tropical countries, and is now found in the
West Indies, South America, Tropical Western Africa, and Queensland in
Australia.

=History=—Ginger is known in India under the old name of _Sringavera_,
derived possibly from the Greek Ζιγγίβερι. As a spice it was used among
the Greeks and Romans, who appear to have received it by way of the
Red Sea, inasmuch as they considered it to be a production of Southern
Arabia.

In the list of imports from the Red Sea into Alexandria, which in
the second century of our era were there liable to the Roman fiscal
duty (_vectigal_), _Zingiber_ occurs among other Indian spices.[2350]
During the middle ages it is frequently mentioned in similar lists, and
evidently constituted an important item in the commercial relations
between Europe and the East. Ginger thus appears in the tariff of
duties levied at Acre in Palestine about A.D. 1173;[2351] in that of
Barcelona[2352] in 1221; Marseilles[2353] in 1228; and Paris[2354]
in 1296. The _Tarif des Péages_, or customs tariff, of the Counts of
Provence in the middle of the 13th century, provides for the levying
of duty at the towns of Aix, Digne, Valensole, Tarascon, Avignon,
Orgon, Arles, &c., on various commodities imported from the East.
These included spices, as pepper, _ginger_, cloves, zedoary, galangal,
cubebs, saffron, canella, cumin, anise; dye-stuffs, such as lac,
indigo, Brazil wood, and especially alum from Castilia and Volcano; and
groceries, as racalicia (liquorice), sugar and dates.[2355]

In England ginger must have been tolerably well known even prior to
the Norman Conquest, for it is frequently named in the Anglo-Saxon
leech-books of the 11th century, as well as in the Welsh “Physicians
of Myddvai” (see Appendix). During the 13th and 14th centuries it was,
next to pepper, the commonest of spices, costing on an average nearly
1_s._ 7_d._ per lb., or about the price of a sheep.[2356]

[2349] The mode of cultivation is described by Buchanan, _Journey from
Madras through Mysore, etc._ ii. (1807) 469.—Fig. of the plant in
Bentley and Trimen’s _Medic. Plants_, part 32 (1878).

[2350] Vincent, _Commerce and Navigation of the Ancients_, ii. (1807)
695.

[2351] _Recueil des Historiens des Croisades_; _Lois_, ii. (1843) 176.

[2352] Capmany, _Memorias sobre la Marina, etc. de Barcelona_, Madrid,
ii. (1779) 3.

[2353] Méry et Guindon, _Hist. des Actes ... de la Municipalité de
Marseille_, i. (1841) 372.

[2354] _Revue archéologique_, ix. (1852) 213.

[2355] _Collection de Cartulaires de France_, Paris, viii. (1857) pp.
lxxiii-xci., Abbaye de St. Victor, Marseilles.

[2356] Rogers, _Hist. of Agriculture and Prices in England_, i. (1866)
629.

The merchants of Italy, about the middle of the 14th century, knew
three kinds of ginger, called respectively _Belledi_, _Colombino_, and
_Micchino_. These terms may be explained thus:—_Belledi_ or _Baladi_ is
an Arabic word, which, as applied to ginger, would signify _country_ or
_wild_, i.e. _common ginger_. _Colombino_ refers to Columbum, Kolam or
Quilon, a port in Travancore frequently mentioned in the middle ages.
Ginger termed _Micchino_ denotes that the spice had been brought from
or by way of Mecca.[2357]

Ginger preserved in syrup, and sometimes called _Green Ginger_, was
also imported during the middle ages, and regarded as a delicacy of the
choicest kind.

The plant affording ginger must have been known to Marco Polo (_circa_
1280-90), who speaks of observing it both in China and India. John of
Montecorvino, who visited India about 1292 (see p. 521), describes
ginger as a plant like a flag, the root of which can be dug up and
transported. Nicolo Conti also gave some description of the plant and
of the collection of the root, as witnessed by him in India.[2358]

The Venetians received ginger by way of Egypt; yet some of the superior
kinds were conveyed from India overland by the Black Sea, as stated by
Marino Sanudo[2359] about 1306.

Ginger was introduced into America by Francisco de Mendoça, who took it
from the East Indies to New Spain.[2360] It was shipped for commercial
purposes from the Island of St. Domingo as early at least as 1585; and
from Barbados in 1654.[2361] According to Renny,[2362] 22,053 cwt. were
exported from the West Indies to Spain in 1547.

[2357] Yule, _Book of Ser Marco Polo_, ii. (1871) 316.—See, however,
Heyd, _Levantehandel_, II. (1879) 601.

[2358] See Appendix.

[2359] Marinus Sanutus, _Liber secretorum fidelium crucis_, Hanoviæ
(1611) 22.

[2360] Monardes, _Historia de las cosas que se traen de nuestras Indias
occidentales_, Sevilla, (1574) 99.

[2361] _Calendar of State Papers, Colonial Series_, 1574-1660, Lond.
1860, p. 4; see also pp. 414, 434.

[2362] Renny, _Hist. of Jamaica_, Lond. 1807. 154.

=Description=—Ginger is known in two forms, namely the rhizome dried
with its epidermis, in which case it is called _coated_; or deprived of
epidermis, and then termed _scraped_ or _uncoated_. The pieces, which
are called by the spice-dealers _races_ or _hands_, rarely exceed 4
inches in length, and have a somewhat palmate form, being made up of a
series of short, laterally compressed, lobe-like shoots or knobs, the
summit of each of which is marked by a depression indicating the former
attachment of the leafy stem.

To produce the _uncoated ginger_, which is that preferred for medicinal
use, the fresh rhizome is scraped, washed, and then dried in the sun.

Thus prepared, it has a pale buff hue, and a striated, somewhat fibrous
surface. It breaks easily, exhibiting a short and farinaceous fracture
with numerous bristle-like fibres. When cut with a knife the younger
or terminal portion of the rhizome appears pale yellow, soft and
amylaceous, while the older part is flinty, hard and resinous.

_Coated ginger_, or that which has been dried without the removal of
the epidermis, is covered with a wrinkled, striated brown integument,
which imparts to it a somewhat coarse and crude appearance, which is
usually remarkably less developed on the flat parts of the rhizome.
Internally, it is usually of a less bright and delicate hue than
ginger from which the cortical part has been removed. Much of it indeed
is dark, horny and resinous.

Ginger has an agreeable aromatic odour with a strong pungent taste.

=Varieties=—Those at present found in the London market are
distinguished as _Jamaica_, _Cochin_, _Bengal_, and _African_. The
first three are _scraped_ gingers; the last named is a _coated_ ginger,
that is to say, it still retains its epidermis. Jamaica Ginger is the
sort most esteemed; and next to it the Cochin. But of each kind there
are several qualities, presenting considerable variation _inter se_.

Scraped or decorticated ginger is often bleached, either by being
subjected to the fumes of burning sulphur, or by immersion for a
short time in solution of chlorinated lime. Much of that seen in the
grocers’ shops looks as if it had been whitewashed, and in fact is
slightly coated with calcareous matter,—either sulphate or carbonate of
calcium.[2363]

[2363] Mr. Garside (_Pharm. Journ._ April 18, 1874) found both. We have
not observed the carbonate to be used.

=Microscopic Structure=—A transverse section of coated ginger exhibits
a brown, horny external layer, about one millimètre broad, separated by
a fine line from the whitish mealy interior portion, through the tissue
of which numerous vascular bundles and resin-cells are irregularly
scattered. The external tissue consists of a loose outer layer, and an
inner composed of tabular cells: these are followed by peculiar short
prosenchymatous cells, the walls of which are sinuous on transverse
section and partially thickened, imparting a horny appearance. This
delicate felted tissue forms the striated surface of _scraped ginger_,
and is the principal seat of the resin and volatile oil, which here
fill large spaces. The large-celled parenchyme which succeeds is loaded
with starch, and likewise contains numerous masses of resin and drops
of oil. The starch granules are irregularly spherical, attaining at
the utmost 40 mkm. Certain varieties of ginger, owing to the starch
having been rendered gelatinous by scalding, are throughout horny and
translucent. The circle of vascular bundles which separates the outer
layers and the central portion is narrow, and has the structure of the
corresponding circle or nucleus-sheath in turmeric.

=Chemical Composition=—Ginger contains a volatile oil which is the
only constituent of the drug that has hitherto been investigated. By
distilling 112 lb. of Jamaica ginger with water in the usual way, we
obtained 4½ ounces of this oil, or about ¼ per cent. It is a pale
yellow liquid of sp. gr. 0·878, having the peculiar odour of ginger,
but not its pungent taste. It dissolves but sparingly in alcohol
(0·83); and deviates the ray of polarized light 21°.6 to the left, when
examined in a column 50 mm. long. We learn from kind information given
us (1878) by Messrs. Schimmel & Co. at Leipzig, that they obtain as
much as 2·2 per cent. of oil from good ginger.

The burning taste of ginger is due to a resin which we have not
examined, but which well deserves careful analysis. Protocatechuic
acid, which is so commonly afforded by resins (see page 243), is also
produced by melting the resin of ginger with caustic potash, as shown
in 1877 by Stenhouse and Groves.

=Commerce=—Great Britain imported of ginger as follows:—

      1868          1869        1870          1871          1872
    52,194 cwt.   34,535 cwt.  33,854 cwt.   32,723 cwt.   32,174 cwt.

In 1876 the imports were 62,164 cwt., valued at £169,252.

The drug was received in 1872 thus:—

    From Egypt                   4,923 cwt.
      ”  Sierra Leone            6,167  ”
      ”  British India          13,310  ”
      ”  British West Indies     7,543  ”
      ”  other countries           231  ”
                                ------
                    Total       32,174

The shipments from Jamaica during the years 1866 to 1876 varied from
599,786 lb. in 1872 to 1,728,075 in 1867. In 1876 there were exported
1,603,764 lb., valued at £28,882.[2364]

=Uses=—Ginger is an agreeable aromatic and stomachic, and as such is
often a valuable addition to other medicines. It is much more largely
employed as a condiment than as a drug.


RHIZOMA CURCUMÆ.

_Radix Curcumæ_;[2365] _Turmeric_; F. _Curcuma_; G. _Gelbwurzel_,
_Kurkuma_.

=Botanical Origin=—_Curcuma longa_[2366] L.—Turmeric is indigenous to
Southern Asia, and is there largely cultivated both on the continent
and in the islands.

=History=—Dioscorides mentions an Indian plant as a kind of _Cyperus_
(Κύπειρος) resembling ginger, but having when chewed a yellow colour
and bitter taste: probably turmeric was intended. Garcia de Orta
(1563), as well as Fragoso (1572), describe turmeric as _Crocus
indicus_. A list of drugs sold in the city of Frankfort about the year
1450, names _Curcuma_ along with zedoary and ginger.[2367]

In its native countries, it has from remote times been highly esteemed
both as a condiment and a dye-stuff; in Europe, it has always been less
appreciated than the allied spices of the ginger tribe. In an inventory
of the effects of a Yorkshire tradesman, dated 20th Sept., 1578, we
find enumerated—“_x. owncis of turmeracke, x d._”[2368]

[2364] Statist. Abstract (as quoted p. 633, note 3), p. 71.

[2365] _Curcuma_ from the Persian _kurkum_, a name applied also to
saffron. The origin of the word _Turmeric_ is not known to us; _Terra
merita_ seems to be a corruption of it.

[2366] Fig. in Bentley and Trimen’s _Med. Plants_, part 9. (1876).

[2367] Flückiger, _Die Frankfurter Liste_, Halle, 1873. 11.

[2368] Raine, _Wills and Inventories of the Archdeaconry of Richmond_
(Surtees Society), 1853. 277.

=Description=—The base of the scrape thickens in the first year into
an ovate rootstock; this afterwards throws out shoots, forming lateral
or secondary rhizomes, each emitting roots, which branch into fibres
or are sometimes enlarged as colourless spindle-shaped tubers, rich in
starch. The lateral rhizomes are doubtless in a condition to develope
themselves as independent plants when separated from the parent.
The central rhizomes formerly known as _Curcuma rotunda_, and the
elongated lateral ones as _Curcuma longa_, were regarded by Linnæus as
the production of distinct species.

The radical tubers of some species of _Curcuma_, as _C. angustifolia_
Roxb., are used for making a sort of arrowroot (p. 637). Sometimes
they are dried, and constitute the peculiar kind of turmeric which the
Chinese call _Yuh-kin_.[2369]

The turmeric of commerce consists of the two sorts of rhizome just
mentioned, namely, the _central_ or _round_ and the _lateral_ or
_long_. The former are ovate, pyriform or subspherical, sometimes
pointed at the upper end and crowned with the remains of leaves, while
the sides are beset with those of roots and marked with concentric
ridges. The diameter is very variable, but is seldom less than ¾ of
an inch, and is frequently much more. They are often cut and usually
scalded in order to destroy their vitality and facilitate drying.

The lateral rhizomes are subcylindrical, attenuated towards either end,
generally curved, covered with a rugose skin, and marked more or less
plainly with transverse rings. Sometimes one, two or more short knobs
or shoots grow out on one side. The rhizomes, whether round or long,
are very hard and firm, exhibiting when broken a dull, waxy, resinous
surface, of an orange or orange-brown hue, more or less brilliant. They
have a peculiar aromatic odour and taste.

Several varieties of turmeric distinguished by the names of the
countries or districts in which they are produced, are found in the
English market: but although they present differences which are
sufficiently appreciable to the eye of the experienced dealer, the
characters of each sort are scarcely so marked or so constant as to
be recognizable by mere verbal description. The principal sorts now
in commerce are known as _China_, _Madras_, _Bengal_, _Java_, and
_Cochin_. Of these the first-named is the most esteemed, but it is
seldom to be met with in the European market.[2370]

_Madras Turmeric_ is a fine sort in large, bold pieces. Sometimes
packages of it contain exclusively round rhizomes, while others are
made up entirely of the long or lateral.

_Bengal Turmeric_ differs from the other varieties chiefly in its
deeper tint, and hence is the sort preferred for dyeing purposes.

_Java Turmeric_ presents no very distinctive features; it is dusted
with its own powder, and does not show when broken a very brilliant
colour. Judging by the low price at which it is quoted it is not
in great esteem. It is the produce of _Curcuma longa_ var. β.
_minor_[2371] Hassk.

[2369] Hanbury, _Pharm. Journ._ iii. (1862) 206; also _Science Papers_,
254, fig. 11.—It is not wholly devoid of yellow colouring matter.

[2370] A good deal is exported from Takow in Formosa, but mostly to
Chinese ports.—_Returns of Trade at the Treaty Ports of China for
1872._ p. 106.

[2371] From information communicated by Mr. Binnendyk, of the Botanical
Garden, Buitenzorg, Java.

=Microscopic Structure=—The suberous coat is made up of 8 to 10 rows
of tabular cells; the parenchyme of the middle cortical layer of large
roundish polyhedral cells. Towards the centre the transverse section
exhibits a coherent ring of fibro-vascular bundles representing a kind
of medullary sheath. The parenchyme enclosed by this ring is traversed
by scattered bundles of vessels, and in most of its cells contains
starch in amorphous, angular, or roundish masses, which are so far
disorganized that they no longer exhibit the usual appearance in
polarized light, but are nevertheless turned blue by iodine. The starch
has been reduced to this condition by scalding.

Resin likewise occurs in separate cells, forming dark yellowish-red
particles. The entire tissue is penetrated with yellow colouring
matter, and shows numerous drops of essential oil, which in the fresh
rhizome is no doubt contained in peculiar cells.

=Chemical Composition=—The drug yielded us (1876) one per cent. of a
yellow essential oil, which contains a portion boiling at 250° C.,
answering to the formula C₁₀H₁₄O; this liquid differs from carvol (p.
306) by being unable to combine with SH₂. The other constituents of
curcuma oil boil at temperatures much above 250°; we found the crude
oil and its different portions slightly dextrogyrate.

The aqueous extract of the drug tastes bitter, and is precipitated by
tannic acid.

The colouring matter, _Curcumin_, C₁₀H₁₁₀O₃, may be obtained to the
amount of ⅓ per cent. by depriving first the drug of fat and essential
oil. The powder, after that treatment with bisulphide of carbon, is
gradually exhausted, according to Daube (1871), with warm petroleum
(boiling point 80°-90° C.). On cooling chiefly the last portions of
petroleum deposit the crystalline curcumin. Its alcoholic solution
is purified by mixing it cautiously with basic acetate of lead, not
allowing the liquid to assume a decidedly acid reaction. The red
precipitate thus formed is collected, washed with alcohol, immersed
in water, and decomposed with sulphuretted hydrogen. From the dried
mixture of sulphide of lead and curcumin the latter is lastly removed
by boiling alcohol.

By Ivanow-Gajewsky (1873) the best produce of curcumin is stated to be
obtained by washing an ethereal extract of turmeric with weak ammonia,
dissolving the residue in boiling concentrated ammonia, and passing
into the solution carbonic acid, by which the curcumin is precipitated
in flakes.

After due recrystallization from alcohol curcumin forms yellow
crystals, having an odour of vanilla, and exhibiting a fine blue in
reflected light. They melt at 165° C. Curcumin is scarcely soluble,
even in boiling water, but dissolves readily on addition of an alkali
either caustic or carbonate. On acidulating these solutions, a yellow
powder of curcumin is precipitated. Curcumin is not abundantly
dissolved by ether, very sparingly by benzol or bisulphide of carbon.
It is not volatile; heated with zinc dust it yields an oil boiling at
290°; fused with caustic potash, curcumin affords protocatechuic acid
(page 243).

Paper tinged with an alcoholic solution of curcumin displays on
addition of an alkali a brownish-red coloration, becoming violet on
drying. Boracic acid produces an orange tint, turning blue by addition
of an alkaline solution.[2372] This behaviour of (impure) curcumin was
pointed out by Vogel as early as 1815, and has since that time been
utilized as a chemical test.

[2372] The following is a striking experiment, showing some of these
changes of colour:—Place a little crushed turmeric or the powder on
blotting paper, and moisten it repeatedly with chloroform, allowing the
latter to evaporate. There will thus be formed on the paper a yellow
stain, which on addition of a slightly acidulated solution of borax and
drying assumes a purple hue. If the paper is now sprinkled with dilute
ammonia it will acquire a transient blue. This reaction enables one to
recognize the presence of turmeric in powdered rhubarb or mustard.

Borax added to an alcoholic solution of curcumin gives rise to a
crystallizable substance, which Ivanow-Gajewsky (1870) isolated by
heating an alcoholic extract of turmeric with boracic and sulphuric
acids. It forms a purple crystalline powder with a metallic green
lustre, insoluble in water, but soluble in alcohol. Its solution is
coloured dark blue by an alkali.

According to the same chemist there also exists in curcuma an alkaloid
in very small quantity. Kachler (1870) found in the aqueous decoction
an abundance of _bioxalate of potassium_.

=Commerce=—In the year 1869 there were imported into the United Kingdom
64,280 cwt. of turmeric; in 1870, 44,900 cwt.,—a very large proportion
being furnished by Bengal and Pegu. The export from Calcutta[2373] in
the year 1870-71 was 59,352 cwt.

Bombay exported in the year 1871-72, 29,780 cwt., of which the greater
portion was shipped to Sind and the Persian Gulf, and only 910 cwt. to
Europe.[2374]

=Uses=—Turmeric is employed as a condiment in the shape of curry
powder, and as such is often sold by druggists; but as a medicine it is
obsolete. It is largely consumed in dyeing.

=Substitute=—_Cochin Turmeric_ is the produce of some other species of
_Curcuma_ than _C. longa_. It consists exclusively of a bulb-shaped
rhizome of large dimensions, cut transversely or longitudinally
into slices or segments. The cortical part is dull brown; the inner
substance is horny and of a deep orange-brown, or when in thin shavings
of a brilliant yellow. Mr. A. Forbes Sealy of Cochin has been good
enough to send us (1873) living rhizomes of this _Curcuma_, which he
states is mostly grown at Alwaye, north-east of Cochin, and is never
used in the country as _turmeric_, though its starchy tubers are
employed for making arrowroot. The rhizomes sent are thick, short,
conical, and of enormous size, some attaining as much as 2½ inches in
diameter. Internally they are of a bright orange-yellow.

The beautiful figures of Roscoe[2375] show several species of Curcuma
and Zingiber provided with yellow tubers or rhizomes, all probably
containing curcumin.

[2373] Returns quoted at p. 571, note 2.

[2374] _Statement of the Trade and Navigation of Bombay for_ 1871-72,
pt. ii. 95.

[2375] _Monandrous Plants of the order Scitamineæ_, Liverpool, 1828,
especially _Zingiber Cossumunar_.


RHIZOMA GALANGÆ.

_Radix Galangæ[2376] minoris_; _Galangal_; F. _Racine de Galanga_; G.
_Galgant_.

=Botanical Origin=—_Alpinia officinarum_ Hance,[2377] a flag-like
plant, with stems about 4 feet high, clothed with narrow lanceolate
leaves, and terminating in short and simple racemes of elegant white
flowers, shaded and veined with dull red. It grows cultivated in the
island of Hainan in the south of China, and, as is supposed, in some of
the southern provinces of the Chinese Empire.

[2376] _Galanga_ appears to be derived from the Arabic name
_Khulanjan_, which in turn comes from the Chinese _Kau-liang Kiang_,
signifying, as Dr. F. Porter Smith has informed us, _Kau-liang ginger_.
Kau-liang is the ancient name of a district in the province of
Kwangtung.

[2377] _Journ. of Linnean Society_, Botany, xiii. (1871) 1; also
Trimen’s _Journ. of Bot._, ii. (1873) 175; Bentley and Trimen’s _Med.
Plants_, part 31 (1878).—Dr. Thwaites of Ceylon, who has the plant in
cultivation, has been good enough to send us a fine coloured drawing of
it in flower.

=History=—The earliest reference to galangal we have met with occurs
in the writings of the Arabian geographer Ibn Khurdádbah[2378] about
A.D. 869-885, who in enumerating the productions of a country called
Sila, names galangal together with musk, aloes, camphor, silk, and
cassia. Edrisi,[2379] three hundred years later, is more explicit,
for he mentions it with many other productions of the far East, as
brought from India and China to Aden, then a great emporium of the
trade of Asia with Egypt and Europe. The physician Alkindi,[2380] who
lived at Bassora and Bagdad in the second half of the 9th century,
and somewhat later Rhazes and Avicenna, notice galangal, the use of
which was introduced into Europe[2381] through the medical system
promulgated by them and other writers of the same school. As to Great
Britain, galingal, as it was frequently spelt, also occurs in the Welsh
“Meddygon Myddfai” (see Appendix).

Many notices exist showing that galangal was imported with pepper,
ginger, cloves, nutmegs, cardamoms and zedoary; and that during the
middle ages it was used in common with these substances as a culinary
spice, which it is still held to be in certain parts of Europe.[2382]
The plant affording the drug was unknown until the year 1870, when a
description of it was communicated to the Linnean Society of London by
Dr. H. F. Hance, from specimens collected by Mr. E. C. Taintor, near
Hoihow in the north of Hainan.

[2378] Work quoted in the Appendix—tome v. 294.

[2379] _Géographie_, i. (1836) 51.

[2380] _De Rerum gradibus_, Argentorati, 1531. 162.

[2381] Macer Floridus (see p. 627), cap. 70, was already acquainted
with it.

[2382] Hanbury, _Historical Notes on the Radix Galangæ of
pharmacy—Journ. of Linnean Society_, Bot. xiii. (1871) 20; _Pharm.
Journ._ Sept. 23, 1871. 248; _Science Papers_, 370.

=Description=—The drug consists of a cylindrical rhizome, having
a maximum diameter of about ¾ of an inch, but for the most part
considerably smaller. This rhizome has been cut while fresh into short
pieces, 1½ to 3 inches in length, which are often branched, and are
marked transversely at short intervals by narrow raised sinuous rings,
indicating the former attachment of leaves or scales. The pieces
are hard, tough and shrivelled, externally of a dark reddish-brown,
displaying when cut transversely an internal substance of rather paler
hue (but never white), with a darker central column. The drug exhales
when comminuted an agreeable aroma, and has a strongly pungent, spicy
taste.

=Microscopic Structure=—The central portion of the rhizome is separated
from the outer tissue by the nucleus-sheath, which appears as a
well-defined darker line. Yet the central tissue does not differ much
from that surrounding it, both being composed of uniform parenchyme
cells, traversed by scattered vascular bundles. There also occur
throughout the whole tissue isolated cells loaded with essential oil or
resin. But the larger number of cells abound in large starch granules
of an unusual club-shaped form. Some cells contain a brown substance,
differing from resin in being insoluble in alcohol. The corky layer is
remarkable from its cells having undulated walls.

=Chemical Composition=—The odour of galangal is due to an essential
oil, which the rhizoma yields to the extent of only 0·7 per cent., and
which we found to be very slightly deviating the plane of polarization
to the left.

Brandes[2383] extracted from Galangal, by means of ether, an inodorous,
tasteless, crystalline body called _Kämpferid_, which is worthy of
further examination.

The pungent principle of the drug, which is probably analogous to that
of ginger, has not been studied.

=Commerce=—Galangal is shipped from Canton to other ports of China, to
India and Europe, but there are no general statistics to give an idea
of the total production. From official returns quoted by Hance, the
export of the year 1869, which seems to have been exceptionally large,
amounted to 370,800 lb. From Kiung-chow, island of Hainan, 2,113 peculs
(281,733 lb.) were exported in 1877.

=Uses=—The drug is an aromatic stimulant of the nature of ginger, now
nearly obsolete in British medicine. It is still a popular remedy and
spice in Livonia, Esthonia and central Russia, and by the Tartars is
taken with tea. It is also in some requisition in Russia among brewers,
and the manufacturers of vinegar and cordials, and finally as a cattle
medicine.

=Substitute=—The rhizoma of _Alpina Galanga_ Willd., a plant of Java,
constitutes the drug known as _Radix Galangæ majoris_ or _Greater
Galangal_, packages of which occasionally appear in the London drug
sales. It may be at once distinguished from the Chinese drug by its
much larger size and the pale buff hue of its internal substance, the
latter in strong contrast with the orange-brown outer skin.


FRUCTUS CARDAMOMI.

_Semina Cardamomi minoris_; _Cardamoms_, _Malabar Cardamoms_; F.
_Cardamomes_; G. _Cardamomen_.

=Botanical Origin=—_Elettaria[2384] Cardamomum_ Maton (_Alpinia
Cardamomum_ Roxb.), a flag-like perennial plant, 6 to 12 feet high,
with large lanceolate leaves on long sheathing stalks, and flowers in
lax flexuose horizontal scapes, 6 to 18 inches in length, which are
thrown out to the number of 3 or 4, close to the ground. The fruit is
ovoid, three-sided, plump and smooth, with a fleshy green pericarp.

The Cardamom plant grows abundantly, both wild and under cultivation,
in the moist shady mountain forests of North Canara, Coorg and Wynaad
on the Malabar Coast; at an elevation of 2500 to 5000 feet above
the sea. It is truly wild in Canara and in the Anamalai, Cochin and
Travancore forests.[2385] The cardamom region has a mean temperature of
22° C. (72° F.), and a mean rainfall of 121 inches.

[2383] _Archiv der Pharm._ xix. (1839) 52.

[2384] From _Elettari_, the Mallyalim name of the plant.—Fig. in
Bentley and Trimen’s _Med. Plants_, part 24 (1877).

[2385] The small “_Cardamom_“ island in the Laccadive group, west of
Malabar, is inhabited by Moplahs, known (as we are informed by Dr.
King, Calcutta) in the south of India as dealers in cardamoms.

A well-marked variety, differing chiefly in the elongated form and
large size of its fruits, is found wild in the forests of the central
and southern provinces of Ceylon. It was formerly regarded as a
distinct species under the name of _Elettaria major_, but careful
observation of growing specimens has shown that it possesses no
characters to warrant it being considered more than a variety of the
typical plant, and it is therefore now called _E. Cardamomum_ var. β.
It is only known to occur in Ceylon, where the ordinary cardamom of
Malabar is not found except as a cultivated plant.[2386]

=History=—Cardamoms, _Elā_, are mentioned in the writings of Susruta,
and hence may have been used in India from a remote period. It is not
unlikely that in common with ginger and pepper they reached Europe in
classical times, although it is not possible from the descriptions
that have come down to determine exactly what was the Καρδάμωμον of
Theophrastus and Dioscorides, or the Ἄμωμον of the last named writer.
The _Amomum_, _Amomis_ and _Cardamomum_ of Pliny are also doubtful, the
description he gives of the last being unintelligible as applied to
anything now known by that name.

In the list of Indian spices liable to duty at Alexandria, _circa_
A.D. 176-180 (see Appendix, A), _Amomum_ as well as _Cardamomum_ is
mentioned. St. Jerome names _Amomum_ together with musk, as perfumes in
use among the voluptuous ecclesiastics of the 4th century.[2387]

Cardamoms are named by Edrisi[2388] about A.D. 1154 as a production of
Ceylon, and also as an article of trade from China to Aden; and in the
same century they are mentioned together with cinnamon and cloves (p.
282) as an import in Palestine by way of Acre, then a trading city of
the Levant.[2389]

The first writer who definitely and correctly states the country of the
cardamom appears to be the Portuguese navigator Barbosa[2390] (1514),
who frequently names it as a production of the Malabar coast. Garcia
de Orta[2391] mentions the shipment of the drug to Europe; he also
ascertained that the larger sort was produced in Ceylon. The Malabar
cardamon plant was figured by Rheede under its indigenous name of
_Elettari_.[2392]

[2386] Thwaites, _Enumeratio Plantarum Zeylaniæ_, 1864. 318.

[2387] _S. Hieronymi Opera Omnia_, ed. Migne, ii. (1845) 297, in
_Patrologiæ cursus completus_, vol. xxii.

[2388] In the work quoted in the Appendix, i. (1836) 73, 51.—It is
questionable whether _Elettaria_ is intended at p. 51.

[2389] A _long_ and _curious article_ on _cardamoms_, by a pharmacist
of Cairo, 13th century, named _Abul Mena_, is quoted by Leclerc,
_Histoire de la Médecine arabe_, ii. (Paris, 1876) 215.

[2390] _Description of the Coasts of East Africa and Malabar_, Hakluyt
Society, 1866. 59. 64, 147. 154. etc.

[2391] In the work quoted at p. 547, note 8.

[2392] _Hortus Malabaricus_, xi. (1692) tab. 4-5.

The essential oil of cardamoms was distilled before 1544 by Valerius
Cordus (see p. 526, note 1).

=Cultivation and Production=—Although the cardamom plant grows wild in
the forests of Southern India, where it is commonly called _Ilāchi_,
its fruits are largely obtained from cultivated plants. The methods
of cultivation, which vary in the different districts, may be thus
described:—

1. Previous to the commencement of the rains the cultivators ascend
the mountain sides, and seek in the shady evergreen forests a spot
where some cardamom plants are growing. Here they make small clearings,
in which the admission of light occasions the plant to develope in
abundance. The cardamom plants attain 2 to 3 feet in height during the
following monsoon, after which the ground is again cleared of weeds,
protected with a fence, and left to itself for a year. About two years
after the first clearing the plants begin to flower, and five months
later ripen some fruits, but a full crop is not got till at least
a year after. The plants continue productive six or seven years. A
garden, 484 square yards in area, four of which may be made in an
acre of forest, will give on an average an annual crop of 12½ lbs. of
garbled cardamoms.[2393] Ludlow, an Assistant Conservator of Forests,
reckons that not more than 28 lbs. can be got from an acre of forest.
From what he says, it further appears that the plants which come up
on clearings of the Coorg forests are mainly _seedlings_, which make
their appearance in the same _quasi_-spontaneous manner as certain
plants in the clearings of a wood in Europe. He says they commence
to bear in about 3½ years after their first appearance.[2394] The
plan of cultivation above described is that pursued in the forests of
Travancore, Coorg and Wynaad.

2. On the lower range of the Pulney Hills, near Dindigul, at an
elevation of about 5,000 feet above the sea, the cardamom plant is
cultivated in the shade. The natives burn down the underwood, and clear
away the small trees of the dense moist forests called _sholas_, which
are damp all the year round. The cardamoms are then sown, and when a
few inches high are planted out, either singly or in twos, under the
shade of the large trees. They take five years before they bear fruit:
“in October,” remarks our informant,[2395] “I saw the plants in full
flower and also in fruit,—the latter not however ripe.”

[2393] _Report on the Administration of Coorg for the year 1872-73_,
Bangalore, 1873. 44.

[2394] Elliot, _Experiences of a Planter in the Jungles of Mysore_,
Lond. ii. (1871) 201, 209.

[2395] Col. Beddome, Conservator of Forests, Madras. We have
likewise to acknowledge information on this head from Dr. Brandia,
Inspector-General of Forests in India, and Dr. King, Director of the
Botanic Garden, Calcutta.

3. In North Canara and Western Mysore the cardamom is cultivated in
the betel-nut plantations. The plants, which are raised from seed, are
planted between the palms, from which and from plantains they derive a
certain amount of shade. They are said to produce fruit in their third
year.

Cardamoms begin to ripen in October, and the gathering continues during
dry weather for two or three months. All the fruits on a scape do not
become ripe at the same time, yet too generally the whole scape is
gathered at once and dried,—to the manifest detriment of the drug.
This is done partly to save the fruit from being eaten by snakes,
frogs and squirrels, and partly to avoid the capsules splitting, which
they do when quite mature. In some plantations however the cardamoms
are gathered in a more reasonable fashion. As they are collected the
fruits are carried to the houses, laid out for a few days on mats,
then stripped from their scapes, and the drying completed by a gentle
fire-heat. In Coorg the fruit is stripped from the scape before drying,
and the drying is sometimes effected wholly by sun-heat.

In the native states of Cochin and Travancore cardamoms are a monopoly
of the respective governments. The rajah of the latter state requires
that all the produce shall be sold to his officials, who forward it to
the main depôt at Alapalli or Aleppi, a port in Travancore, where his
commercial agent resides. The rajah is tenacious of his rights, and
inserts a clause in the leases he grants to European coffee-planters,
of whom a great many have settled in his territory, requiring that
cardamoms shall not be grown.

The cardamoms at Aleppi are sold by auction, and bought chiefly by
Moplah merchants for transport to different parts of India, and also,
through third parties, to England. All the lower qualities are consumed
in India, and the finer alone shipped to Europe.

In the forests belonging to the British Government cardamoms are mostly
reckoned among the miscellaneous items of produce; but in Coorg, the
cardamom forests are now let at a rental of £3,000 per annum under a
lease which will expire in 1878.[2396]

Dr. Cleghorn, late Conservator of Forests in the Madras Presidency,
observes in a letter to one of us, that the rapid extension of coffee
culture along the slopes of the Malabar mountains has tended to lessen
the production of cardamoms, and has encroached considerably upon the
area of their indigenous growth. A recent writer[2397] has shown from
his own experience that the cultivation of the cardamom is a branch of
industry worth the attention of Europeans, and has given many valuable
details for insuring successful results.

[2396] Report quoted at p. 645. note 1.

[2397] Elliot, _op. cit._, chap. 12.

=Description=—The fruit of the Malabar cardamom as found in
commerce is an ovoid or oblong, three-sided, three-valved capsule,
containing numerous seeds arranged in three cells. It is rounded
at the base, and often retains a small stalk; towards the apex it
is more or less contracted, and terminates in a short beak. The
longitudinally-striated, inodorous, tasteless pericarp is of a pale
greyish-yellow, or buff, or brown when fully ripe, of a thin papery
consistence, splitting lengthwise into three valves. From the middle
of the inner side of each valve a thin partition projects towards the
axis, thereby producing three cells, each of which encloses 5 to 7 dark
brown, aromatic seeds, arranged in two rows and attached in the central
angle.

The seeds, which are about two lines long, are irregularly angular,
transversely rugose, and have a depressed hilum and a deeply channelled
raphe. Each seed is enclosed in a thin colourless aril.

Cardamoms vary in size, shape, colour and flavour: those which are
shortly ovoid or nearly globular, and ⁴/₁₀ to ⁶/₁₀ of an inch in
length, are termed in trade language _shorts_; while those of a more
elongated form, pointed at each end, and ⁷/₁₀ to ⁹/₁₀ of an inch long,
are called _short-longs_. They are further distinguished by the names
of localities, as Malabar (or Mangalore), Aleppi, and Madras. The
_Malabar Cardamoms_, which are the most esteemed, are of full colour,
and occur of both forms, namely _shorts_ and _short-longs_; they are
brought to Europe _viâ_ Bombay. Those terms _Aleppi_ are generally
_shorts_, plump, beaked and of a peculiar greenish tint; they are
imported from Calicut, and sometimes from Aleppi. The _Madras_ are
chiefly of elongated form (_short-longs_) and of a more pallid hue;
they are shipped at Madras and Pondicherry.

Cardamoms are esteemed in proportion to their plumpness and heaviness,
and the sound and mature condition of the seeds they contain. Good
samples afford about three-fourths of their weight of seeds.[2398]

The fruits of the second form (var. β) of _Elettaria Cardamomum_, known
in trade as _Ceylon Cardamoms_, are from 1 to 2 inches in length, and
³/₁₀ to ⁴/₁₀ of an inch in breadth, distinctly three-sided, often
arched, and always of a dark greyish-brown. The seeds are larger and
more numerous than those of the Malabar plant, and somewhat different
in odour and taste.

=Microscopic Structure=—The testa of the seed consists of three
distinct layers, namely an exterior of thick-walled, spirally-striated
cells, somewhat longitudinally extended, and exhibiting on transverse
section, square, not very large, cavities; then a row of large cells
with thin transverse walls; and finally, an internal layer of deep
brown, radially-arranged cells, the walls of which have so thick a
deposit that at the most only small cavities remain.

The granular, colourless, sac-shaped albumen encloses a horny
endosperm, in which the embryo is inserted the projecting radicle
being directed towards the hilum. The cells of the albumen have the
form of elongated polyhedra, almost entirely filled with very small
starch granules. Besides them, there occur in most of the cells,
somewhat larger masses of albuminoid matter having a rhombohedric form,
distinctly observable when thin slices of the seed are examined under
almond oil in polarized light. These remarkable crystalloid bodies
resemble those occurring in the seeds of cumin (p. 332).

=Chemical Composition=—The parenchyme of the albumen and embryo is
loaded with fatty oil and essential oil, the former existing in the
seed to the extent of about 10 per cent.

The percentage of essential oil is stated by Messrs. Schimmel & Co.,
Leipzig, to be equal to 5 in the Madras Cardamoms, and to 3·5 in the
Ceylon. We found the latter to be dextrogyrate; the same gentlemen
presented us (1876) with a crystallized deposit from the latter oil,
which appears to be _identical with common camphor_. Its alcoholic
solution deviates the plane of polarization to the right, apparently to
the same amount as that of common camphor (see also oil of spike, p.
479).

Dumas and Péligot (1834) state to have obtained from the essential oil
of cardamoms (inodorous?) crystals of terpin, C₁₀H₁₆ + 3 OH₂. The ash
of cardamoms, in common with that of several other plants of the same
order, is remarkably rich in manganese.[2399]

=Commerce=—There are no statistics to show the production of cardamoms
in the south of India or even the quantity exported. The shipments in
the year 1872-73 from Bombay, to which port the drug is largely sent
from the Madras Presidency, amounted to 1,650 cwt., of which 1,055 cwt.
were exported to the United Kingdom.[2400]

Cardamoms, the produce of Ceylon and therefore of the _large_ variety,
were exported from that island in 1872 to the extent of 9,273 lb.—the
whole quantity being shipped to the United Kingdom.[2401]

[2398] Thus 202 lb. shelled at various times during 10 years, afforded
154½ lb. of seeds. (Information from the laboratory accounts of Messrs.
Allen and Hanburys, Plough Court, Lombard Str.).

[2399] _Pharm. Journ._ iii. (1872) 208.

[2400] _Statement of the Trade, etc. of Bombay for 1872-73._ ii. 58. 90.

[2401] _Ceylon Blue Book for 1872_, Colombo, 1873. 543.

=Uses=—Cardamoms are an agreeable aromatic, often administered in
conjunction with other medicines. As an ingredient in curry powder,
they have also some use as a condiment. But the consumption in England
is small in comparison with what it is in Russia, Sweden, Norway and
parts of Germany, where they are constantly employed as a spice for the
flavouring of cakes. In these countries Ceylon cardamoms are also used,
but exclusively for the manufacture of liqueurs. In India, cardamoms,
besides being used in medicine, are employed as a condiment and for
chewing with betel.

Other sorts of Cardamom.

The fruits of several other plants of the order _Zingiberaceæ_ have
at various times been employed in pharmacy under the common name of
_Cardamom_. We shall here notice only those which have some importance
in European or Indian commerce.[2402]

_Round or Cluster Cardamom_—_Amomum Cardamomum_ L., the mother plant of
this drug, is a native of Cambodia, Siam, Sumatra and Java.

During the intercourse with Siam, which was frequent in the early
part of the 17th century, this drug, which is there in common use,
occasionally found its way into Europe. Clusius received a specimen
of it in 1605 as the true _Amomum_ of the ancients, and figured it
as a great rarity.[2403] As _Amomum verum_ it had a place in the
pharmacopœias of this period. Parkinson (1640), who figures it as
_Amomum genuinum_, says that “of late days it hath been sent to Venice
from the East Indies.” Dale (1693) and Pomet (1694) both regarded it as
a rare drug; the latter says it is brought from Holland, and that it is
the only thing that ought to be used when _Amomum_ is ordered. In 1751
it was so scarce that in making the _Theriaca Andromachi_ some other
drug had always to be substituted for it.[2404]

Thus it had completely disappeared, when about the year 1853 commercial
relations were re-opened with Siam; and among the commodities poured
into the market were _Round Cardamoms_. They were not appreciated, and
the importations becoming unprofitable, soon ceased.[2405] They are
nevertheless an article of considerable traffic in Eastern Asia.

Round Cardamoms are produced in small compact bunches.[2406] Each
fruit is globular, ⁵/₁₀ to ⁷/₁₀ of an inch in diameter, marked
with longitudinal furrows, and sometimes distinctly three-lobed.
The pericarp is thin, fragile, somewhat hairy, of a buff colour,
enclosing a three-lobed mass of seeds, which are mostly shrivelled
as if the fruit had been gathered unripe. The seeds, which have a
general resemblance to those of the Malabar cardamom, have a strong
camphoraceous, aromatic taste.

[2402] For additional information on the various sorts of Cardamom,
consult Guibourt, _Hist. des Drog._ ii. (1869) 215-227; Pereira,
_Elements of Mat. Med._ ii., part i. (1855) 243-263; Hanbury in _Pharm.
Journ._ xiv. (1855) 352. 416; _Science Papers_, 93-15.

[2403] _Exoticorum Libri_, 377. Yet it already occurs in the
_Dispensatorium_ of Valerius Cordus.

[2404] Hill, _Hist. of the Mat. Med._, Lond. (1751) 472.

[2405] Thus 43 bags, imported direct from Bangkok, were offered for
sale in London, 26 March, 1857, and bought in at 1_s._ 6_d._ per lb.

[2406] Fig. in Guibourt, _l. c._ 215.

There is a large export from Siam of cardamoms of this and the
following sort. The shipments from Bangkok in 1871 amounted to 4,678
peculs (623,733 lbs.), and were all to Singapore and China.[2407]
In 1875 we noticed the export from Bangkok of 267 peculs of “true”
cardamoms, valued at 45,140 dollars, and 3,267 peculs of “bastard”
cardamoms, value 92,865 dollars; the latter no doubt refer to the
following kind:[2408]—

_Xanthioid Cardamom_; _Wild or Bastard Cardamom of Siam_—This is
afforded by _Amomum xanthioides_ Wallich, a native of Tenasserim and
Siam. During the past thirty years the seeds of this plant, deprived
of their capsules, have often been imported into the London market,
and they are now also common in the bazaars of India.[2409] They
closely resemble the seeds of the Malabar cardamom, differing chiefly
in flavour and in being rather more finely rugose. Occasionally they
are imported still cohering in ovoid, three-lobed masses, as packed in
the pericarp. Sometimes they are distinguished as _Bastard_ or _Wild_,
but are more generally termed simply _Cardamom Seeds_. They are a
considerable article of trade in Siam.

The fruits of this species grow in round clusters and are remarkable
for having the pericarp thickly beset with weak fleshy spines,[2410]
which gives them some resemblance to the fruits of a _Xanthium_, and
has suggested the specific name.

_Bengal Cardamom_—This drug, which with the next two has been hitherto
confounded under one name,[2411] is afforded by _Amomum subulatum_
Roxb.,[2412] a native of the Morung mountains, to the S.S.W. of
Darjiling, in about 26°·30′ N. lat. The fruit is known by the name
of _Winged Bengal Cardamom_, _Morung Elachi_ or _Buro Elachi_. They
average about an inch in length, and are of ovoid or slightly obconic
form, and obscurely 3-sided; the lower end is rounded and usually
devoid of stalk. The upper part of the fruit is provided with 9 narrow
jagged wings or ridges, which become apparent after maceration; and the
summit terminates in a truncate bristly nipple,—never protracted into a
long tube. The pericarp is coarsely striated, and of a deep brown. It
easily splits into 3 valves, inclosing a 3-lobed mass of seeds, 60 to
80 in number, agglutinated by a viscid saccharine pulp, due to the aril
with which each seed is surrounded. The seeds are of roundish form,
rendered angular by mutual pressure, and about ⅛ of an inch long; they
have a highly aromatic, camphoraceous taste.

[2407] _Commercial Report of H.M. Consul-General in Siam for 1871._

[2408] _Science Papers_, 102-103.

[2409] Moodeen Sheriff, _Supplement to Pharmacopœia of India_, Madras,
1869. 44. 270.

[2410] See figures in _Pharm. Journ._ xiv. (1855) 418; also _Science
Papers_, 1876, p. 101-103.

[2411] As by Pereira, _Elem. of Mat. Med._ ii. (1850) 1135.

[2412] According to Dr. King, in Sir Joseph Hooker’s _Report on the
Royal Gardens at Kew_, 1877. 27.

_Nepal Cardamom_—The description of the Bengal cardamom applies in many
points to this drug, to which it has a singularly close resemblance.
The fruit is of the same size and form, and is also crowned in its
upper part with thin jagged ridges, and marked in a similar manner
with longitudinal striæ; and lastly, the seeds have the same shape and
flavour. But it differs, firstly, in bearing on its summit a tubular
calyx, which is as long or longer than the fruit itself; and, secondly,
in the fruit being often attached to a short stalk. The fruits are
borne on an ovoid scape, 3 to 4 inches long, densely crowded with
overlapping bracts, which are remarkably broad and truncate with a
sharp central claw,—very distinct from the much narrower ovate bracts
of _A. aromaticum_, as shown in Roxburgh’s unpublished drawing of that
plant.

The plant, which is unquestionably a species of _Amomum_, has not
yet been identified with any published description. We have to thank
Colonel Richard C. Lawrence, British Resident at Katmandu, for sending
us a fruit-scape in alcohol, some dried leaves, and also the drug
itself,—the last agreeing perfectly with specimens obtained through
other channels.

The Nepal cardamom, the first account of which is due to
Hamilton,[2413] is cultivated on the frontiers of Nepal, near
Darjiling. The plant is stated by Col. Lawrence to attain 3 to 6 feet
in height, and to be grown on well-watered slopes of the hills, under
the shelter of trees. The fruit is exported to other parts of India.

_Java Cardamom_—A well-marked fruit, produced by _Amomum maximum_
Roxb., a plant of Java. The fruits are arranged to the number of 30
to 40 on a short thick scape, and form a globose group, 4 inches in
diameter. They are stalked, and of a conical or ovoid form, in the
fresh state as much as 1½ inches long by 1 inch broad. Each fruit is
provided with 9 to 10 prominent wings, ⅛ of an inch high, running from
base to apex, and coarsely toothed except in their lowest part. The
summit is crowned by a short, withered, calycinal tube.

Mr. Binnendyk, of the Botanical garden of Buitenzorg, in Java, who has
kindly supplied us with fine specimens of _A. maximum_, as well as with
an admirable coloured drawing, states that the plant is cultivated, and
that its fruits are sold for the sake of their agreeable edible pulp.
We do not know whether the dried fruits or the seeds are ever exported.
Pereira confounded them with Bengal and Nepal cardamoms.

_Korarima Cardamom_—The Arab Physicians were acquainted with a sort
of cardamom called _Heil_, which was later known in Europe, and is
mentioned in the most ancient printed pharmacopœias as _Cardamomum
majus_,[2414] a name occurring also in Valerius Cordus and Mattiolus.
Like some other Eastern drugs, it gradually disappeared from European
commerce, and its name came to be transferred to _Grains of Paradise_,
which to the present day are known in the shops as _Semina Cardamomi
majoris_.

[2413] _Account of the Kingdom of Nepal_, Edin. 1819. 74-75.

[2414] As the _Tesaurus Aromatariorum_, printed at Milan in 1496, in
which it is called _Heil_ or _Gardamomum majus_.

The true _Cardamomum majus_ is a conical fruit,[2415] in size and shape
not unlike a small fig reversed, containing roundish angular seeds,
of an agreeable aromatic flavour, much resembling that of the Malabar
cardamom, and quite devoid of the burning taste of grains of paradise.
Each fruit is perforated, having been strung on a cord to dry; such
strings of cardamoms are sometimes used by the Arabs as rosaries. The
fruit in question is called in the Galla language _Korarima_, but it
is also known as _Gurági_ spice, and by its Arabic names of _Heil_
and _Habhal-habashi_.[2416] According to Beke,[2417] it is conveyed to
the market of Báso (10° N. lat.), in Southern Abyssinia, from Tumhé, a
region lying in about 9° N. lat. and 35° E. long.; thence it is carried
to Massowah, on the Red Sea, and shipped for India and Arabia. Von
Heuglin[2418] speaks of it as brought from the Galla country. It is not
improbable that it is the same fruit which Speke[2419] saw growing in
1862 at Uganda, in lat 0°, and which he says is strung like a necklace
by the Wagonda people. Under the name of _Heel Habashee_, Korarima
cardamoms were contributed in 1873 from Shoa to the Vienna exhibition;
we have also been presented, in 1877, with an excellent specimen of
them, recently imported, by Messrs. Schimmel & Co., Leipzig.

Pereira proposed for the plant the name of _Amomum Korarima_, but it
has never been botanically described. It would appear from the above
statements that it must be indigenous to the whole mountainous region
of Eastern Africa, from the Victoria Nyanza lake (Uganda) to the
countries of Tumhé, Gurague, and Shoa, south and south-eastward of
Abyssinia.


GRANA PARADISI.

_Semina Cardamomi majoris_, _Piper Melegueta_; _Grains of Paradise_,
_Guinea Grains_, _Melegueta Pepper_; F. _Grains de Paradis_,
_Maniguette_; G. _Paradieskörner_.

=Botanical Origin=—_Amomum Melegueta_ Roscoe—an herbaceous, reed-like
plant, 3 to 5 feet high, producing on a scape rising scarcely an inch
above the ground, a delicate, wax-like, pale purple flower, which is
succeeded by a smooth, scarlet, ovoid fruit, 3 to 4 inches in length,
rising out of sheathing bracts.[2420]

[2415] Figured in Pereira, _Materia Medica_ ii. part i. (1855) 250, and
already in Mattioli’s _Commentar. in Dioscorid._ lib. i. (1558) 27.

[2416] So named by Forskal in 1775 (_Materia Medica Kahirina_, 151. n.
41) who says “_frequens in re culinariâ et medicâ, loco piperis_.”

[2417] _Letters on the commerce of Abyssinia_, etc., addressed to the
Foreign Office, 1852; 4. 16. 20.

[2418] _Reise nach Abessinien_, Jena, 1868. 223.

[2419] _Journal of the discovery of the source of the Nile_, 1863. 648.

[2420] Fig. in Bentley and Trimen’s _Medical Plants_, part 30 (1878).

It varies considerably in the dimensions of all its parts, according to
more or less favourable circumstances of soil and climate. In Demerara,
where the plant grows luxuriously in cultivation, the fruit is as large
as a fine pear, measuring with its tubular part as much as 5 inches in
length by 2 inches in diameter; on the other hand, in some parts of
West Africa it scarcely exceeds in size a large filbert. It has a thick
fleshy pericarp, enclosing a colourless acid pulp of pleasant taste, in
which are imbedded the numerous seeds.

_A. Melegueta_ is widely distributed in tropical West Africa, occurring
along the coast region from Sierra Leone to Congo. The littoral region,
termed, in allusion to its producing grains of paradise, the _Grain
Coast_, _Pepper Coast_, or _Melegueta Coast_, lies between Liberia and
Cape Palmas; or, more exactly, between Capes Mesurado (Montserrado)
and St. Andrews. The Gold Coast, whence the seeds are now principally
exported, is in the Gulf of Guinea, further eastward.

Of the distribution of the plant in the interior we have no exact
information. Yet the name Melegueta refers to the ancient empire of
Melle (Meli or Melly), formerly extending over the upper Niger region,
about in 4° E. long., and then inhabited by the Mandingos, now by
the Fulbe or Fullãn. Messena is their most considerable place. In
that region _Amomum Melegueta_ may be indigenous, or the spice, being
formerly exported from the coast by way of Melle, took its commercial
name in allusion to the latter.

=History=—There is no evidence that the ancients were acquainted with
the seeds called _Grains of Paradise_; nor can we find any reference
to them earlier than an incidental mention under their African name,
in the account[2421] of a curious festival held at Treviso in A.D.
1214: it was a sort of tournament, during which a sham fortress, held
by twelve noble ladies and their attendants, was besieged and stormed
by assailants armed with flowers, fruits, sweetmeats, perfumes, and
spices, amongst which last figure—_Melegetæ_!

After this period there are many notices, showing the seeds to have
been in general use. Nicolas Myrepsus,[2422] physician at the court
of the Emperor John III. at Nicœa, in the 13th century, prescribed
Μνεγέται; and his contemporary, Simon of Genoa,[2423] at Rome, names
the same drug as _Melegete_ or _Melegette_. _Grana Paradisi_ are
enumerated among spices sold at Lyons[2424] in 1245, and were used
about the same time by the Welsh Physicians of Myddvai under the name
_Grawn Paris_.[2425] They also occur as _Greyn Paradijs_ in a tariff of
duties levied at Dordrecht in Holland[2426] in 1358. And again among
the spices used by John, king of France, when in England, A.D. 1359-60,
_Grainne de Paradis_ is repeatedly mentioned.[2427]

In the earliest times the drug was conveyed by the long land journey
from the Mandingo country through the desert to the Mediterranean
port, Monte di Barca (Mundibarca), on the coast of Tripoli. There the
spice was shipped by the Italians, and being the produce of an unknown
region and held in great esteem, it acquired the name of _Grains of
Paradise_,[2428] or also, as already stated at page 650, that of
_Semina Cardamomi Majoris_. That they came from Melli is expressly
stated also by Leonhard Fuchs.[2429] Small quantities of the drug still
reach Tripoli in the same way.

Towards the middle of the 14th century, there began to be direct
commercial intercourse with tropical Western Africa. Margry[2430]
relates that ships were sent thither from Dieppe in 1364, and took
cargoes of ivory and _malaguette_ from near the mouth of the river
Cestos, now Sestros. A century later the coast was visited by the
Portuguese, who termed it _Terra de malaguet_. The celebrated
Columbus also, who traded to the coast of Guinea, called it _Costa di
Maniguetta_. Soon after this period the spice became a monopoly of the
kings of Portugal.

[2421] Rolandini Patavini _Chronica_—Pertz, _Monumenta Germaniæ
historica; scriptores_, xix. (1866) 45-46.—Yet _qâfala_, occurring in
Edrisi, probably means grains of paradise.

[2422] _De Compositione Medicamentorum; de antidotis_, cap. xxii.

[2423] _Clavis Sanationis_, Venet. 1510. 19. 42.

[2424] _Bibliothek d. lit. Vereins_, Stuttgart, xvi. p. xxiii.

[2425] _Meddygon Myddfai_ (see Appendix) 283. 286.

[2426] Sartorius and Lappenberg, _Geschichte der Deutschen Hansa_, ii.
448.

[2427] Doüet d’Arcq, 219, 266—see p. 533, note 2.

[2428] G. di Barros, _Asia_, Venet. 1561. 33 (65).

[2429] _De componendorum miscendorumque medicamentorum ratione_, libr.
iv. Lugduni, 1556. 50.

[2430] Quoted at p. 589, note 4.

English voyagers visited the Gold Coast in the 16th century, bringing
thence in exchanging for European goods, gold, ivory, pepper, and
_Grains of Paradise_.[2431] The pepper was doubtless that of _Piper
Clusii_ (p. 589).

Grains of paradise, often called simply _grains_, were anciently used
as a condiment like pepper. They were also employed with cinnamon and
ginger in making the spiced wine called _hippocras_, in vogue during
the 14th and 15th centuries.

In the Portuguese and Spanish idioms, the name _Melegueta_, spelt in
various ways, as _Melegette_, _Melligetta_, _Mallaguetta_, _Manigete_,
_Maniguette_, was subsequently also applied to other substitutes of
pepper, and even to that spice itself.

In the hands of modern botanists, the plant affording grains of
paradise has been the subject of a complication of errors which it is
needless to discuss. Suffice it to say, that _Amomum Granum Paradisi_
as described by Linnæus cannot be identified;—that in 1817, Afzelius,
a Swedish botanist, who resided some years at Sierra Leone, published
a description of “_Amomum Granum Paradisi_? Linn.,”[2432] but that
the specimen of it alleged to have been received from him, and now
preserved in the herbarium of Sir J. E. Smith, belongs to another
species. Under these circumstances, the name given to the grains of
paradise plant by Roscoe, _A. Melegueta_, has been accepted as quite
free from doubt.[2433]

=Description=—The seeds are about ⅒ of an inch in diameter, rather
variable in form, being roundish, bluntly angular or somewhat
pyramidal. They are hard, with a shining, reddish-brown, shagreen-like
surface. The hilum is beak-shaped and of paler colour. The seeds when
crushed are feebly aromatic, but have a most pungent and burning taste.

=Microscopic Structure=—In structure, grains of paradise agree in most
respects with cardamom seeds. Yet in the former, the cells of the
albumen have very thin, delicate walls which are much more elongated.
Of the testa, only the innermost layer agrees with the corresponding
part of cardamom; whilst the middle layer has the cell-walls so much
thickened that only a few cavities, widely distant from one another,
remain open. The outer layer of the testa consists of thick-walled
cells, the cavities of which appear, on transverse section, radially
extended. The albumen is loaded with starch granules of 2 to 5 mkm.
diameter, the whole amount in each cell being agglutinated, so as to
form a coherent mass.

=Chemical Composition=—Grains of paradise contain a small proportion of
essential oil; 53 lb. yielded us only 2½ oz., equivalent to nearly 0·30
per cent.[2434] The oil is faintly yellowish, neutral, of an agreeable
odour reminding one of the seeds, and of an aromatic, not acrid taste.
It has a sp. gr. at 15·5° C., of 0·825. It is but sparingly soluble
in absolute alcohol or in spirit of wine; but mixes clearly with
bisulphide of carbon; it dissolves iodine without explosion. When
saturated with dry hydrochloric gas, no solid compound is formed.

[2431] Hakluyt, _Principal Navigations_, ii. pt. 2.—First Voiage of the
_Primerose and Lion_ to Guinea and Benin, A.D. 1553.

[2432] _Remedia Guineensia_, Upsaliæ, p. 71.

[2433] I have repeatedly raised _Amomum Melegueta_ from commercial
Grains of Paradise, and have cultivated the plant for some years,
obtaining not only flowers, but large well-ripened fruits containing
fertile seeds.—D. H.

[2434] This oil was obtained and tried in medicine in the beginning of
the 17th century.—Porta, _De Distillatione_, Romæ, 1608, lib. iv. c. 4.

The oil begins to boil at about 236° C., and the chief bulk of it
distills at 257°-258°: the residual part is a thick brownish liquid.
Examined in a column of 50 mm. long, the crude oil deviates 1·9° to the
left. The portion passing over at 257°-258° deviates 1·2°, the residue
2° to the left. The optical behaviour is consequently in favour of the
supposition that the oil is homogeneous. This is corroborated by the
results of three elementary analyses which lead to the formula C₂₀H₃₂O.

In order to ascertain whether the seed contains a fatty oil, 10
grammes, powdered with quartz, were exhausted with boiling ether. This
gave upon evaporation 0·583 grm. of a brown viscid residue, almost
devoid of odour, but of intense pungency. As it was entirely soluble in
glacial acetic acid or in spirit of wine, we may consider it a _resin_,
and not to contain any fatty matter.

The seeds, dried at 100° C., afforded us 2·15 per cent. of ash, which,
owing to the presence of manganese, had a green hue.

=Commerce=—Grains of paradise are chiefly shipped from the settlements
on the Gold Coast, of which Cape Coast Castle and Accra are the more
important. Official returns[2435] show that the exports in 1871 from
this district were as follows:—to Great Britain 85,502 lb., the United
States 35,630 lb., Germany 28,501 lb., France 27,125 lb., Holland
14,250 lb.—total, 191,011 lb. (1705 cwt.) In 1872 the total shipments
amounted to the enormous quantity of 620,191 lb., valued at £10,303; in
1875 only 151,783 lb., valued at £912, were exported.

=Uses=—The seeds are used in cattle medicines, occasionally as a
condiment, but chiefly, we believe, to give a fiery pungency to
cordials.




ORCHIDACEÆ.


SALEP.

_Radix Salep_, _Radix Satyrii_; _Salep_; F. _Salep_; G. _Salepknollen_.

=Botanical Origin=—Most, if not all, species of _Orchis_ found in
Europe and Northern Asia are provided with tubers which, when duly
prepared, are capable of furnishing salep. Of those actually so used,
the following are the more important, namely—_Orchis mascula_ L., _O.
Morio_ L., _O. militaris_ L., _O. ustulata_ L., _O. pyramidalis_ L.,
_O. coriophora_ L., and _O. longicruris_ Link. These species which have
the tubers _entire_ are natives of the greater part of Central and
Southern Europe, Turkey, the Caucasus and Asia Minor.[2436]

The following species with _palmate_ or _lobed_ tubers have a
geographical area no less extensive, namely _O. maculata_ L., _O.
saccifera_ Brongn., _O. conopsea_ L., and _O. latifolia_ L. The last
named reaches North-Western India and Tibet; and _O. conopsea_ occurs
in Amurland in the extreme east of Asia.

[2435] _Blue Book for the Colony of the Gold Coast in 1871._

[2436] Tchihatcheff enumerates 36 species of _Orchis_ as occurring in
Asia Minor.—_Asie Mineure_, Bot. ii. 1860.

The salep of the Indian bazaars, known as _Sālib misrī_, for fine
qualities of which the most extravagant prices are paid by wealthy
orientals, is derived from certain species of _Eulophia_, as _E.
campestris_ Lindl., _E. herbacea_ Lindl., and probably others.[2437]

=History=—Under the superstitious influence of the so-called _doctrine
of signatures_,[2438] salep[2439] has had for ages a reputation in
Eastern countries as a stimulant of the generative powers; and many
Europeans who have lived in India, although not prepared to admit the
extravagant virtues ascribed to it by Hindus and Mahommedans, yet
regard it as a valuable nutrient in the sick-room.

The drug was known to Dioscorides and the Arabians, as well as to the
herbalists and physicians of the middle ages, by whom it was mostly
prescribed in the fresh state. Gerarde (1636) has given excellent
figures of the various orchids whose tubers, says he, “_our age useth_.”

Geoffroy[2440] having recognized the salep imported from the Levant
to be the tubers of an orchis, pointed out in 1740 how it might be
prepared from the species indigenous to France.

=Collection=—The tubers are dug up after the plant has flowered, and
the shrivelled ones having been thrown aside, those which are plump are
washed, strung on threads and scalded. By this process their vitality
is destroyed, and the drying is easily effected by exposure to the sun
or to a gentle artificial heat. Though white and juicy when fresh, they
become by drying hard and horny, and lose their bitterish taste and
peculiar odour.

Salep is largely collected near Melassa (Milas) and Mughla (or Moola),
south-east of Smyrna, and also brought there from Mersina, opposite the
north-eastern cape (Andrea) of Cyprus. The drug found in English trade
is mostly imported from Smyrna. That sold in Germany is partly obtained
from plants growing wild in the Taunus mountains, Westerwald, Rhön, the
Odenwald, and in Franconia. Salep is also collected in Greece, and used
in that country and Turkey in the form of decoction, which is sweetened
with honey and taken as an early morning drink.[2441] The salep of
India is produced on the hills of Afghanistan, Beluchistan, Kabul and
Bokhara;[2442] the Neilgherry Hills in the south, and even Ceylon are
said likewise to afford it.

[2437] The Indian species of _Eulophia_ have been reviewed by Lindley
in _Journ. of Linn. Soc._ Bot. iii. (1859) 23.

[2438] See Appendix, Porta.

[2439] _Salep_ is the Arabic for _fox_, and the drug is called in that
language _Khus yatu’s salab_, i.e. _fox’s testicle_; or _Khus yatu’l
kalb_, i.e. _dog’s testicle_. The word _Orchis_, and the old English
names _Dogstones_, _Foxstones_, _Harestones_ and _Goatstones_ have all
been given in allusion to the form of the tubers.

[2440] _Mém. de l’Acad. des Sciences_ for 1740. 99.

[2441] Heldreich, _Nutzpflanzen Griechenlands_, Athen, 1862. 9.

[2442] Powell, _Economic Products of the Punjab_, Roorkee, i. (1868)
261; Stewart, _Punjab Plants_, Lahore, 1869. 236.

=Description=—Levant salep, such as is found in the English market,
consists of tubers half an inch to an inch in length, of ovoid or
oblong form, often pointed at the lower end, and rounded at the
upper where is a depressed scar left by the stem; palmate tubers
are unfrequent. They are generally shrunken and contorted, covered
with a roughly granular skin, pale brown, translucent, very hard and
horny, with but little odour and a slight not unpleasant taste. After
maceration in water for several hours, they regain their original form
and volume. German salep is more translucent and gummy-looking, and has
the aspect of being more trimmed and prepared.

=Microscopic Structure=—The fresh tuber exhibits on transverse
section a few outer rows of thin-walled cells rich in starch. These
are followed by parenchyme of elongated colourless cells likewise
containing starch, and isolated bundles of acicular crystals of oxalate
of calcium. In this parenchyme, there are numerous larger cells filled
with homogenous mucilage. Small vascular bundles are irregularly
scattered throughout the tuber. In _Orchis mascula_ and _O. latifolia_
the starch grains are nearly globular, and about 25 mkm. in diameter.
In dried salep the cell-walls are distorted and the starch grains
agglomerated.

=Chemical Composition=—The most important constituent of salep is a
sort of mucilage, the proportions of which according to Dragendorff
(1865) amounts to 48 per cent.; but it is doubtless subject to great
variation. Salep yields this mucilage to cold water, forming a solution
which is turned blue by iodine, and mixes clearly with neutral
acetate of lead like gum arabic. On addition of ammonia, an abundant
precipitate is formed. Mucilage of salep precipitated by alcohol and
then dried, is coloured violet or blue, if moistened with a solution of
iodine in iodide of potassium. The dry mucilage is readily soluble in
ammoniacal solution of oxide of copper; when boiled with nitric acid,
oxalic, but not mucic acid is produced. In these two respects, the
mucilage of salep agrees with cellulose, rather than with gum arabic.
In the large cells in which it is contained, it does not exhibit
any stratification, so that its formation does not appear due to a
metamorphosis of the cell-wall itself. Mucilage of salep contains some
nitrogen and inorganic matter, of which it is with difficulty deprived
by repeated precipitation by alcohol.

It is to the mucilage just described that salep chiefly owes its power
of forming with even 40 parts of water a thick jelly, which becomes
still thicker on addition of magnesia or borax. The starch however
assists in the formation of this jelly; yet its amount is very small,
or even _nil_ in the tuber bearing the flowering stem, whereas the
young lateral tuber abounds in it. The starch so deposited is evidently
consumed in the subsequent period of vegetation, thus explaining the
fact that tubers are found, the decoction of which is not rendered blue
by iodine. Salep contains also sugar and albumin, and when fresh, a
trace of volatile oil. Dried at 110° C., it yields 2 per cent. of ash,
consisting chiefly of phosphates and chlorides of potassium and calcium
(Dragendorff).

=Commerce=—The shipments of salep from Smyrna are about 5000 okkas (one
okka equal to 283·2 lb. avdp. = 128·5 kilogrammes) annually.

=Uses=—Salep possesses no medicinal powers; but from its property of
forming a jelly with a large proportion of water, it has come to be
regarded as highly nutritious,—a popular notion in which we do not
concur. A decoction flavoured with sugar and spice, or wine, is an
agreeable drink for invalids, but is not much used in England.[2443]

[2443] As powdered salep is difficult to mix with water, many persons
fail in preparing this decoction; but it may be easily managed by first
stirring the salep with a little spirit of wine, then adding the water
_suddenly_ and boiling the mixture. The proportions are powdered salep
1 drachm, spirit 1½ fluid drachms, water ½ a pint.


VANILLA.

_Vanilla_;[2444] F. _and_ G. _Vanille_.

=Botanical Origin=—_Vanilla planifolia_ Andrews—Indigenous to the hot
regions (_tierra caliente_) of Eastern Mexico, diffused by cultivation
through other tropical countries. The plant, which is rather fleshy
and has large greenish inodorous flowers,[2445] grows in moist, shady
forests, climbing the trees by means of its aërial roots.

=History=—The Spaniards found vanilla in use in Mexico as a condiment
to chocolate, and by them it was brought to Europe; but it must have
long remained very scarce, for Clusius, who received a specimen in
1602 from Morgan, apothecary to Queen Elizabeth, described it as
_Lobus oblongus aromaticus_, without being in the least aware of
its native country or uses.[2446] In the _Thesaurus_ of Hernandez
there is a figure and account of the plant under the name of _Araco
aromatico_.[2447]

In the time of Pomet (1694) vanilla was imported by way of Spain, and
was much used in France for flavouring chocolate and scenting tobacco.
It had a place in the materia medica of the London Pharmacopœia of
1721, and was well known to the druggists of the first half of the 18th
century, after which it seems to have gradually disappeared from the
shops. Of late times it has been imported in great abundance, and is
now plentifully used, not only by the chocolate manufacturer, but also
by the cook and confectioner.

=Cultivation=—The culture of vanilla is very simple. Shoots about
three feet long having been fastened to trees, and scarcely touching
the ground, soon strike roots on to the bark, and form plants which
commence to produce fruit in three years, and remain productive for
thirty to forty.

The fertilization of the flower is naturally brought about by insect
agency. This was practised as early as 1830 by Neumann in the Jardin
des Plantes at Paris, and in 1837 by Morren,[2448] the director of the
Botanical Garden of Liège, since which the production of the pods has
been successfully carried on in all tropical countries[2449] without
the aid of insects. Even in European forcing houses the plant produces
fruits of full size, which for aroma bear comparison with those of
Mexico.

In vanilla plantations the pods are not allowed to arrive at complete
maturity, but are gathered when their green colour begins to change.
According to the statements of De Vriese,[2450] they are dried
by a rather circuitous process, namely by exposing them to heat
alternately uncovered, and wrapped in woollen cloths, whereby they are
artificially ripened, and acquire their ultimate aroma and dark hue.
They are then tied together into small bundles.

[2444] Diminutive of the Spanish _vaina_, a pod or capsule.

[2445] Beautifully figured in Berg and Schmidt’s _Offizinelle
Gewächse_, xxxiii. tab. _a_ and _b_ (1862).

[2446] _Exotica_ (1605) lib. iii. c. 18. 72.

[2447] _Rerum Medicarum Novæ Hispaniæ Thesaurus_, Romæ, 1651. p.
38.—The original drawing was one of a series of 1200, executed at
great cost in Mexico by order of the King of Spain during the previous
century.

[2448] _Ann. of Nat. Hist._ iii. (1839) 1.

[2449] In Réunion it was introduced in 1839 by Perrottet, the
well-known botanist. See Delteil, _Etude sur la Vanille_, Paris, 1874.
54 pages, 2 plates.

[2450] _De Vanielje_, Leyden, 1856. 22, with figures.

In Réunion the drying of the pods is performed since 1857 by dipping
them previously in boiling water.

=Description=—The fruit when fresh is of the thickness of the little
finger, obscurely triquetrous, opening longitudinally by two unequal
valves. It is fleshy, firm, smooth, and plump; when cut transversely
it exudes an inodorous slimy juice, abounding in spiculæ of oxalate of
calcium.[2451] It is one-celled, with a three-sided cavity, from each
wall of which projects a two-branched placenta, each branch subdividing
into two backward-curling lobes. There are thus in all 12 ridges, which
traverse the fruit lengthwise, and bear the seeds. Fine hair-like
papillæ line as a thick fringe the three angles of the cavity, and
secrete the odorous matter, which after drying is diffused through the
whole pod. The papillæ likewise contain drops of oil, which is freely
absorbed by the paper in which a pod is wrapped. That the odorous
matter is not resident in the fleshy exterior mass we have ascertained
by slicing off this portion of a fresh fruit and drying it separately;
the interior alone proved to be fragrant.

The vanilla of commerce occurs in the form of fleshy, flexible,
stick-like pods, 3 to 8 inches long, and ³/₁₀ to ⁴/₁₀ of an inch wide,
of a compressed cylindrical form, attenuated and hooked at the stalk
end. The surface is finely furrowed lengthwise, shining, unctuous, and
often beset with an efflorescence of minute colourless crystals. The
pod splits lengthwise into two unequal valves, revealing a multitude of
minute, shining, hard, black seeds of lenticular form, imbedded in a
viscid aromatic juice.

The finest vanilla is the Mexican. _Bourbon Vanilla_, which is the
more plentiful, is generally shorter and less intense in colour, and
commands a lower price.

=Microscopic Structure=—The inner half of the pericarp contains about
20 vascular bundles, arranged in a diffuse ring. The epidermis is
formed of a row of tabular thick-walled cells, containing a granular
brown substance. The middle layer of the pericarp is composed of large
thin-walled cells, the outer of which are axially extended, while those
towards the centre have a cubic or spherical form. All contain drops of
yellowish fat and brown granular masses, which do not decidedly exhibit
the reaction of tannin. The tissue further encloses needles of oxalate
of calcium and prisms of vanillin.

On the walls of the outer cells of the pericarp[2452] are deposited
spiral fibres, which occur still more conspicuously in the aërial roots
and in the parenchyme of the leaves of other orchids. The placentæ are
coated with delicate, thin-walled cells.

[2451] This juice like that of the squill has an irritating effect on
the skin, a fact of which the cultivators in Mauritius are well aware.

[2452] Vanilla grown in Europe is devoid of such cells. We can fully
corroborate this statement (first made by Berg) from the examination
of very aromatic pods produced in 1871 at Hillfield House, Reigate.
We have even failed in finding those cells in any vanilla of recent
importation (1878).

=Chemical Composition=—Vanilla owes the fragrance for which it is
remarkable to _Vanillin_, which is found in a crystalline state in the
interior or on the surface of the fruit, or dissolved in the viscid
oily liquid surrounding the seeds. It was formerly regarded as cinnamic
or benzoic acid, and then as cumarin, until Gobley (1858) demonstrated
its peculiar nature.

The admirable researches of Tiemann and Haarmann performed in
Hofmann’s laboratory at Berlin (1874-1876) have shown that vanillin is
constituted according to the formula

         {OCH₃
    C₆H₃ {OH.
         {CHO

It is the aldehyde. It is the aldehyde of methyl-protocatechuic acid,
and like other aldehydes yields a crystallized compound with the
bisulphites of alkalis. This is obtained by shaking an ethereal extract
(_e_) of vanilla, with a saturated solution of bisulphite of sodium.
The vanillin compound remaining in aqueous solution is mixed with
sulphuric acid and ether; the latter on evaporation affords crystals of
vanillin. They melt at 81°, and may be sublimed by cautiously heating
them. Vanillin is but sparingly soluble in cold water, and requires
about 11 parts of it at 100° C. for solution; it strikes a fine dark
violet with perchloride of iron.

The said chemists have further demonstrated that vanillin may be formed
artificially. In the sapwood of pines there occurs a substance called
_Coniferin_, C₁₆H₂₂O₈ + 2 H₂O, first observed in 1861 by Hartig. By
means of emulsin coniferin taking up H₂O, can be resolved into sugar
and another crystallizable substance:—C₁₆H₂₂O₈ + H₂O = C₆H₁₂O₆ +
C₁₀H₁₂O₃. The second substance thus derived may be collected by means
of ether, which dissolves neither coniferin nor sugar. By oxidizing it,
or coniferin itself, by bichromate of potassium and sulphuric acid,
_Vanillin_ is obtained. The latter has been for sometime manufactured
in that way by Tiemann, but now eugenol (see p. 285) is used for that
purpose. Another source for vanillin is benzoin (p. 409).

The amount of vanillin was stated by Haarmann and Tiemann to be 1·69
per cent. in Mexican vanillin, from 1·9 to 2·48 in the Bourbon variety,
and 2·75 in that from Java. The so-called _Vanillon_ affords only 0·4
to 0·7 per cent. of vanillin.

From the above-mentioned ethereal solution (e), after it has been
deprived of vanillin, vanillate of sodium may be removed by a dilute
solution of carbonate of sodium. On acidulating the aqueous solution
crystals of _vanillic acid_,

         {OCH₃
    C₆H₃ {OH     are precipitated.
         {COOH

If the ether of the solution (_e_), after it has been treated with
carbonate of sodium, is allowed to evaporate, a mixture of fatty
substances and a resin are obtained. The latter has a peculiar odour,
somewhat suggestive of castoreum; vanillic acid is almost inodorous.

Leutner (1872) also found in vanilla fatty and waxy matter 11·8, resin
4·0, gum and sugar 16·5 per cent.; and obtained by incineration of the
drug 4·6 per cent. of ash.

=Production and Commerce=—The chief seats of vanilla-production in
Mexico are the slopes of the Cordilleras, north-west of Vera Cruz,
the centre of the culture being Jicaltepec, in the vicinity of
Nautla.[2453] The finest specimens were contributed in 1878 to the
Paris Exhibition from Agapito, Fonticilla, Misantla, Papantla, also
from Teziutlan, province of Puebla. There are likewise “_Baynillales_,”
plantations of vanilla, on the western declivity of the Cordilleras
in the State of Oaxaca, and in lesser quantity in those of Tabasco,
Chiapas, and Yucatan. The eastern parts of Mexico exported in 1864, by
way of Vera Cruz and Tampico, about 20,000 kilo. of vanilla, chiefly to
Bordeaux. Since then the production seems to have much declined, the
importation into France having been only 6,896 kilo. in 1871, and 1,938
in 1872.[2454]

[2453] _Culture du vanillier au Mexique_, in the _Revue Coloniale_,
ii. (1849) 383-390; also J. W. von Müller, _Reisen in ... Mexico_, ii.
(Leipzig, 1864) 284-290.

[2454] _Documents Statistiques réunis par l’Administration des Douanes
sur le Commerce de la France_, année 1872, p. 64.

The cultivation of vanilla in the small French colony of Réunion or
Bourbon (40 miles long by 27 miles broad), introduced by Marchant in
1817 from Mauritius, has of late been very successful, notwithstanding
many difficulties occasioned by the severe cyclones which sweep
periodically over the island, and by microscopic fungi which greatly
injured the plant. In 1849 the export of vanilla from Réunion was 3
kilogrammes, in 1877 it reached 30,973 kilogrammes. The neighbouring
island of Mauritius also produces vanilla, of which it shipped in 1872
7,139 lbs., in 1877 the quantity was 20,481 lbs. There is likewise a
very extensive cultivation of vanilla in Java.

Vanilla comes into the market chiefly by way of France, which country,
according to the official statistics, imported in 1871, 29,914 kilo.
(65,981 lbs.); in 1872, 26,587 (58,643 lbs.); in 1874 that quantity
amounted to 34,906 kilo.

=Uses=—Vanilla has long ceased to be used in medicine, at least in this
country, but is often sold by druggists for flavouring chocolate, ices,
creams, and confectionery.




IRIDACEÆ.


RHIZOMA IRIDIS.

_Radix Iridis Florentinæ_; _Orris Root_; F. _Racine d’Iris_; G.
_Veilchenwurzel_.

=Botanical Origin=—This drug is derived from three species of _Iris_,
namely:—

1. _Iris germanica_ L., a perennial plant with beautiful large deep
blue flowers, common about Florence and Lucca, ascending to the region
of the chestnut. It is also found dispersed throughout Central and
Southern Europe, and in Northern India and Morocco; and is one of the
commonest plants of the gardens round London, where it is known as the
_Blue Flag_.

2. _I. pallida_ Lam., a plant differing from the preceding by flowers
of a delicate pale blue, growing wild in stony places in Istria. It is
abundant about Florence and Lucca in the region of the olive, but is a
doubtful native.

3. _I. florentina_ L., closely allied to _I. pallida_, yet bearing
large white flowers, is indigenous to the coast region of Macedonia
and the south-western shores of the Black Sea, Hersek, in the Gulf
of Ismid, and about Adalia in Asia Minor. It also occurs in the
neighbourhood of Florence and Lucca, but in our opinion only as a
naturalized plant.[2455]

These three species, but especially _I. germanica_ and _I. pallida_,
are cultivated for the production of orris root in the neighbourhood of
Florence. They are planted on the edges of terraces and on waste, stony
places contiguous to cultivated ground. _I. florentina_ is seldom found
beyond the precincts of villas, and is far less common than the other
two.

=History=—In ancient Greece and Rome, orris root was largely used in
perfumery; and Macedonia, Elis, and Corinth were famous for their
unguents of iris.[2456] Theophrastus and Dioscorides were well
acquainted with orris root; the latter, as well as Pliny, remarks that
the best comes from Illyricum, the next from Macedonia, and a sort
still inferior from Libya; and that the root is used as a perfume and
medicine. Visiani[2457] considers that _Iris germanica_ is the Illyrian
iris of the ancients, which is highly probable, seeing that throughout
Dalmatia (the ancient Illyricum) that species is plentiful, and _I.
florentina_ and _I. pallida_ do not occur. At what period the two
latter were introduced into Northern Italy we have no direct evidence,
but it was probably in the early middle ages. The ancient arms of
Florence, a white lily or iris on a red shield,[2458] seem to indicate
that that city was famed for the growth of these plants. Petrus de
Crescentiis[2459] of Bologna, who flourished in the 13th century,
mentions the cultivation of the _white_ as well as of the purple iris,
and states at what season the root should be collected for medicinal
use.

But the true Illyrian drug was held to be the best; and Valerius
Cordus[2460] laments that it was being displaced by the Florentine,
though it might easily be obtained through the Venetians.


[2455] From observations made at Florence in the spring of 1872, I
am led to regard the three species here named as quite distinct. The
following comparative characters are perhaps worth recording:—

_I. germanica_—flower-stem scarcely 1½ times as tall as leaves; flowers
more crowded than in _I. pallida_, varying in depth of colour but never
pale blue.

_I. pallida_—bracts brown and scariose; flower-stem twice as high as
leaves.

_I. florentina_—bracts green and fleshy; flower-stem short as in _I.
germanica_; is a more tender plant than the other two, and blossoms a
little later.—D. H.

[2456] For further information, consult Blümner, _Die gewerbliche
Thätigkeit der Völker des klassischen Alterthums_, 1869. 57. 76. 83.

[2457] _Flora Dalmatica_, i. (1842) 116.

[2458] Dante, _Divina commedia_, cant. xvi.

[2459] _De omnibus agriculturæ partibus_, Basil. 1548. 219.

[2460] _Dispensatorium_, Norimb. 1529. 288.

Orris root mixed with anise was used in England as a perfume for linen
as early as 1480 (p. 311), under which date it is mentioned in the
_Wardrobe Accounts_ of Edward IV.

All the species of iris we have named were in cultivation in England in
the time of Gerarde,—that is, the latter end of the 16th century. The
starch of the rhizome was formerly reckoned medicinal, and directions
for its preparation are to be found in the _Traicté de la Chymie_ of Le
Febvre, i. (1660) 310.

=Production=—The above-mentioned species of iris are known to the
Tuscan peasantry by the one name of _Giaggiolo_. The rhizomes are
collected indiscriminately, the chief quantity being doubtless
furnished by the two more plentiful species, _I. germanica_ and _I.
pallida_. They are dug up in August, are then peeled, trimmed,
and laid out in the sunshine to dry, the larger bits cut off being
reserved for replanting. At the establishment of Count Strozzi,
founded in 1806 at Pontasieve near Florence, which lies in the midst
of the orris district, the rhizomes, collected from the peasants
by itinerant dealers, are separated into different qualities, as
_selected_ (_scelti_) and _sorts_ (_in sorte_), and are ultimately
offered in trade either entire, or in small bits (_frantumi_),
parings (_raspature_), powder (_polvere di giaggiolo o d’ ireos_), or
manufactured into orris peas.

The growing of orris is only a small branch of industry, the crops
being a sort of side-product, but it is nevertheless shared between
the tenant and landowner as is usual on the Tuscan System of
husbandry.[2461]

[2461] Groves, _Pharm. Journ._ iii. (1872) 229.—We have also to thank
him for information communicated personally.

In the mountainous neighbourhood of Verona, the rhizomes of _Giglio
celeste_ or _Giglio selvatico_, _i.e._, Iris germanica, are collected
and chiefly brought to the small places of Tregnano and Illasi,
north-east of Verona. The peasants distinguish the selected long roots
(_radice dritta_), the knotty roots (_radice groppo_) which are used
for the issue-peas, and the fragments (_scarto_) employed in perfumery.

Some orris root is also exported from Botzen in southern Tyrol.

=Description.=—The rootstock is fleshy, jointed and branching,
creeping horizontally near the surface of the ground. It is formed in
old plants of the annual joints of five or six successive years, the
oldest of which are evidently in a state of decay. These joints are
mostly dichotomous, subcylindrical, a little compressed vertically,
gradually becoming obconical, and obtaining a maximum size when about
three years old. They are 3 to 4 inches long and sometimes more than
2 inches thick. Those only of the current year emit leaves from their
extremities. The rhizome is externally yellowish-brown, internally
white and juicy, with an earthy smell and acrid taste. By drying, it
gradually acquires its pleasant violet odour, but it is said not to
attain its maximum of fragrance until it has been kept for two years.

We have carefully compared with each other the fresh rhizomes of the
three species under notice, but are not able to point out any definite
character for distinguishing them apart.

Dried orris root as found in the shops occurs in pieces of 2 to 4
inches long, and often as much as 1¼ inches wide. A full-sized piece
is seen to consist of an elongated, irregularly subconical portion
emitting at its broader end one or two (rarely three) branches which,
having been cut short in the process of trimming, have the form of
short, broad cones, attached by their apices to the parent rootstock.
The rootstock is flattened, somewhat arched, often contorted, shrunken
and furrowed. The lower side is marked with small circular scars,
indicating the point of insertion of rootlets. The brown outer bark
has been usually entirely removed by peeling and paring; and the dried
rhizome is of a dull, opaque white, ponderous, firm and compact. It has
an agreeable and delicate odour of violets, and a bitterish, rather
aromatic taste, with subsequent acridity.

A sort of orris root which has been dried without the removal of the
outer peel, is found under the name of _Irisa_ in the Indian bazaars,
and now and then in the London market. It is, we suppose, the produce
of _Iris germanica_ L. (_I. nepalensis_ Wall.), which, according to
Hooker, is cultivated in Kashmir. Orris root of rather low quality
is now often imported from Morocco; it is obtained, we believe,
exclusively from _I. germanica_.

=Microscopic Structure=—On transverse section, the white bark about
2 mm. broad, is seen to be separated by a fine brown line from the
faintly yellowish woody tissue. The latter is traversed by numerous
vascular bundles, in diffuse and irregular rings, and exhibits here
and there small shining crystals of oxalate of calcium. It is made up
uniformly of large thick-walled spherical porous cells, loaded with
starch granules, which are oval, rather large and very numerous; prisms
of calcium oxalate are also visible. The latter were noticed already by
one of the earliest microscopic observers, Anton van Leeuwenhoek, about
the year 1716. The spiral vessels are small and run in very various
directions. The foregoing description is applicable to any one of the
three species we have named.

=Chemical Composition=—When orris root is distilled with water, a
crystalline substance, called _Orris Camphor_, is found floating on
the aqueous distillate. This substance, which we first obtained from
the laboratory of Messrs. Herrings & Co. of London, is yielded, as we
learn from Mr. Umney, to the extent of 0·12 per cent.—that is to say, 3
cwt. 3 qrs. 23 lb. of rhizome afforded of it 8½ ounces.[2462] Messrs.
Schimmel & Co. of Leipzig also presented us with the same substance, of
which they obtain usually 0·60 to 0·80 per cent. Orris camphor has the
exquisite and persistent fragrance of the drug; we have proved[2463]
that this presumed stearoptene or camphor of orris root consists of
_myristic acid_, C₁₄H₂₈O₂ (see page 508), impregnated with the minute
quantity of essential oil occurring in the drug. The oil itself would
appear not to pre-exist in the living root, but to be formed on drying
it.

By exhausting orris root with spirit of wine, a soft brownish resin
is obtained, together with a little tannic matter. The resin has a
slightly acrid taste; the tannin strikes a green colour with persalts
of iron.

=Commerce=—Orris root is shipped from Leghorn, Trieste and
Mogador,—from the last named port to the extent in 1876 of 834
cwt.[2464] There are no data to show the total imports into Great
Britain. France imported in the year 1870 about 50 tons of orris root.

=Uses=—Frequently employed as an ingredient in tooth-powders, and in
France for making issue-peas; but the chief application is as a perfume.

[2462] The produce of some previous operations, in which 23 cwt. of
orris was distilled, afforded but little over one-tenth per cent.

[2463] _Pharm. Journ._ vii. (1876) 130.

[2464] _Consular Reports_, 1876. 1416.


CROCUS.

_Croci stigmata_; _Saffron_[2465]; F. and G. _Saffran_.

=Botanical Origin=—_Crocus sativus_ L., a small plant with a fleshy
bulb-like corm and grassy leaves, much resembling the common Spring
Crocus of the gardens, but blossoming in the autumn. It has an elegant
purple flower, with a large orange-red stigma, the three pendulous
divisions of which are protruded beyond the perianth.

[2465] The word _Saffron_ is derived from the Arabic _Asfar_, yellow.

The Saffron Crocus is supposed to be indigenous to Greece, Asia Minor,
and perhaps Persia, but it has been so long under cultivation in the
East that its primitive home is somewhat doubtful.[2466]

=History=—Saffron, either as a medicine, condiment, perfume, or dye,
has been highly prized by mankind from a remote period, and has played
an important part in the history of commerce.

Under the Hebrew name _Carcôm_, which is supposed to be the root of
the word _Crocus_, the plant is alluded to by Solomon;[2467] and as
Κρόκος, by Homer, Hippocrates, Theophrastus, and Theocritus. Virgil and
Columella mention the saffron of Mount Tmolus; the latter also names
that of Corycus in Cilicia, and of Sicily, both which localities are
alluded to as celebrated for the drug by Dioscorides and Pliny.

Saffron was an article of traffic on the Red Sea in the first century;
and the author of the Periplus remarks that Κρόκος is exported
from Egypt to Southern Arabia, and from Barygaza in the gulf of
Cambay.[2468] It was well known under the name _kunkuma_ to the earlier
Hindu writers.

It was cultivated at Derbend and Ispahan in Persia, and in Transoxania
in the 10th century,[2469] whence it is not improbable the plant was
carried to China, for according to the Chinese it came thither from the
country of the Mahomedans. Chinese writers have recorded that under the
Yuen dynasty (.D. 1280-1368), it became the custom to mix _Sa-fa-lang_
(Saffron) with food.[2470]

There is evidence to show that saffron was a cultivated production of
Spain[2471] as early as A.D. 961; yet it is not so mentioned, but only
as an eastern drug, by St. Isidore, archbishop of Seville in the 7th
century. As to France, Italy, and Germany, it is commonly said that the
saffron crocus was introduced into these countries by the Crusaders.
Porchaires, a French nobleman, is stated to have brought some bulbs to
Avignon towards the end of the 14th century, and to have commenced the
cultivation in the Comtat Venaissin, where it existed down to recent
times. About the same time, the growing of saffron is said to have been
introduced by the same person into the district of Gâtinais, south of
Paris.[2472] At that period, saffron was one of the productions of
Cyprus,[2473] with which island France was then, through the princes of
Lusignan, particularly related.

[2466] Chappellier has pointed out that _Crocus sativus_ L. is unknown
in a wild state, and that it hardly ever produces seed even though
artificially fertilized; and has argued from these facts that it is
probably a hybrid.—_Bulletin de la Soc. bot. de France_, xx. (1853) 191.

[2467] _Canticles_, ch. iv. 14.

[2468] Lassen, _Indische Alterthumskunde_, iii. (1857) 52.

[2469] Istachri, _Buch der Länder_, übersetzt von Mordtmann, 87. 93.
124. 126; Edrisi, _Géographie_, trad. par Jaubert, 168. 192.

[2470] Bretschneider, _Chinese Botanical Works_, Foochow, 1870. 15.

[2471] _Le Calendrier de Cordoue de l’année_ 961, Leyde, 1873. 33. 109.

[2472] Conrad et Waldmann, _Traité du Safran du Gâtinais_, Paris, 1846.
(23 pages;—no authority quoted).

[2473] De Mas Latrie, _Hist. de l’ile de Chypre_, iii. 498.

During the middle ages, the saffron cultivated at San Gemignano in
Tuscany was an important article of exportation to Genoa.[2474] That
of Aquila in the Abruzzi was also famous, and used to be distinguished
in price-lists till the beginning of the present century; the culture
of saffron is still going on there to a small extent.[2475] The growing
of saffron in Sicily, which was noticed even by Columella, is carried
on to the present day, but the quantity produced is insufficient
even for home consumption.[2476] In Germany and Switzerland, where
a more rigorous climate must have increased the difficulties of
cultivation, the production of saffron was an object of industry in
many localities.[2477]

The saffron crocus is said to have been introduced into England during
the reign of Edward III. (A.D. 1327-1377).[2478] Two centuries later
English saffron was even exported to the Continent, for in a priced
list of the spices sold by the apothecaries of the north of France,
A.D. 1565-70, mention is made of three sorts of saffron, of which
“_Safren d’Engleterre_” is the most valuable.[2479] It was evidently
produced in considerable quantities, for in 1682 we find in the tariff
of the “Apotheke” of Celle, Hanover, crocus austriacus optimus, and
_Crocus communis anglicus_.[2480]

In the beginning of the last century (1723-28), the cultivation
of saffron was carried on in what is described by a contemporary
writer[2481] as—“all that large tract of ground that lies between
Saffron Walden and Cambridge, in a circle of about 10 miles diameter.”
The same writer remarks that saffron was formerly grown in several
other counties of England. The cultivation of the crocus about Saffron
Walden, which was in full activity when Norden[2482] wrote in 1594, had
ceased in 1768, and about Cambridge at nearly the same time.[2483] Yet
the culture must have lingered in a few localities, for in the early
part of the present century a little English saffron was still brought
every year from Cambridgeshire to London, and sold as a choice drug to
those who were willing to pay a high price for it.

Saffron was employed in ancient times to a far greater extent than
at the present day. It entered into all sorts of medicines, both
internal and external; and it was in common use as a colouring and
flavouring ingredient of various dishes for the table,. The drug, from
its inevitable costliness, has been liable to sophistication from
the earliest times. Both Dioscorides and Pliny refer to the frauds
practised on it, the latter remarking—“_adulteratur nihil æquè_.”

During the middle ages the severest enactments were not only made,
but were actually carried into effect, against those who were guilty
of sophisticating saffron, or even of possessing the article in an
adulterated state. Thus at Pisa, in A.D. 1305, the _fundacarii_, or
keepers of the public warehouses, were required by oath and heavy
penalties to denounce the owners of any falsified saffron consigned to
their custody.[2484] The Pepperers of London about the same period were
also held responsible to check dishonest tampering with saffron.[2485]

[2474] Bourquelot, _Foires de la Champagne_, Mém. de l’Acad. des
inscript. et belles-lettres de l’Institut, v. (1865) 286.

[2475] Groves, _Pharm. Journ._ vi. (1875) 215.

[2476] Inzenga, in _Annali d’ Agricoltura Siciliana_, i. (1851) 51.

[2477] Tragus, _De Stirpium_, etc. 1552, p. 763; Ochs, _Geschichte der
Stadt und Landschaft Basel_, iii. (1819) 189.

[2478] Morant, _Hist. and Antiq. of Essex_, ii. (1768) 545.

[2479] The other sorts are “_Safren Calulome_” and “_Safren
Noort_.”—_Archives générales du Pas de Calais_, quoted by Dorvault,
_Revue pharmaceutique de 1858_. p. 58.

[2480] _Pharm. Journ._ vi. (1876) 1023.

[2481] Douglass, _Phil. Trans._ Nov. 1728. 566.

[2482] _Description of Essex_, Camden Society, 1840. 8.

[2483] Morant, _op. cit._; Lysons, _Magna Britannia_, vol. ii. pt. i.
(1808) 36. Lysons records that at Fulbourn, a village near Cambridge,
there had been no _tithe of saffron_ since 1774.

[2484] Bonaini, _Statuti inediti della città di Pisa dal xii. al xiv.
secolo_, iii. (1857) 101.

[2485] Riley, _Memorials of London and London Life in the 13th, 14th,
and 15th centuries_, 1868. 120.

In France, an edict of Henry II., of 18th March, 1550, recites the
advantages derived from the cultivation of saffron in many parts of
the kingdom, and enacts the confiscation and burning of the drug when
falsified, and corporal punishment of offenders.[2486]

The authorities in Germany were far more severe. A _Safranschau_
(Saffron inspection) was established at Nuremberg in 1441, in which
year 13 lb. of saffron was publicly burnt at the Schönen Brunnen
in that city. In 1444, Jobst Findeker was burnt together with his
adulterated saffron! And in 1456, Hans Kölbele, Lienhart Frey, and
a woman, implicated in falsifying saffron, were buried alive. The
_Safranschau_ was still in vigour as late as 1591: but new regulations
for the inspection of saffron were passed in 1613.[2487] There was also
in the same city a _Gewürzschau_, or Spice-inspection, from 1441 to
1797. Similar inspections were established in most German towns during
the middle ages.

=Description=—The flower of the saffron crocus has a style 3 to 4
inches long, which in its lower portion is colourless, and included
within the tube of the perianth. In its upper part it becomes yellow,
and divides into three tubular, filiform, orange-red stigmas, each
about an inch in length. The stigmas expand towards their ends, and
the tube of which they consist is toothed at the edge and slit on its
inner side. The stigma is the only part officinal, and alone is rich in
colouring matter.

Commercial saffron (_Hay Saffron_ of the druggists) is a loose mass of
thread-like stigmas, which when unbroken are united in threes at the
upper extremity of the yellow style. It is unctuous to the touch, tough
and flexible; of a deep orange-red, peculiar aromatic smell, and bitter
and rather pungent taste. It is hygroscopic and not easily pulverized;
it loses by drying at 100° C. about 12 per cent. of moisture, which it
quickly reabsorbs.[2488]

[2486] De la Mare, _Traité de la Police_, Paris, iii. (1719) 428.

[2487] J. F. Roth, _Geschichte des Nürnbergischen Handels_, 1800-1802,
iv. 221.

[2488] Eight lots of saffron weighing _in toto_ 61 lb., dried at
various times during the course of nine years, lost 7 lb. 2¼ oz.,
_i.e._ 11·7 per cent.—(Laboratory records of Messrs. Allen & Hanburys,
Plough Court, Lombard Street.)

The colouring power of saffron is very remarkable: we have found that
a single grain rubbed to fine powder with a little sugar will impart a
distinct tint of yellow to 700,000 grains (10 gallons) of water.

=Microscopic Structure=—The tissue of the stigma consists of very thin,
sinuous, closely-felted, thread-shaped cells, and small spiral vessels.
The yellow colouring matter penetrates the whole, and is partly
deposited in granules. The microscope likewise exhibits oil-drops, and
small lumps, probably of a solid fat. Large isolated pollen grains are
also present.

=Chemical Composition=—The splendid colouring matter of saffron has
long been known as _Polychroit_; but in 1851 Quadrat, who instituted
some fresh researches on the drug, gave it the name of _Crocin_, which
was also adopted in 1858 by Rochleder. Weiss in 1867[2489] has shown
that it is a glucoside, for which he retains the name of _Polychroit_,
while the new colouring matter which results from its decomposition he
terms _Crocin_. It agrees with the _Crocetin_ of Rochleder.

Polychroit was prepared by Weiss in the following manner: saffron was
treated with ether, by which fat, wax, and essential oil were removed;
and it was then exhausted with water. From the aqueous solution,
gummy matters and some inorganic salts were precipitated by strong
alcohol. After the separation of these substances, polychroit was
precipitated by addition of ether. Thus obtained, it is an orange-red,
viscid, deliquescent substance, which, dried over sulphuric acid,
becomes brittle and of a fine ruby colour. It has a sweetish taste,
but is devoid of odour, readily soluble in spirit of wine or water,
and sparingly in absolute alcohol. By dilute acids, it is decomposed
into _Crocin_, sugar, and an aromatic volatile oil having the smell of
saffron. Weiss gives the following formula for this decomposition:—

    C₄₈H₆₀O₁₈ + H₂O = 2(C₁₆H₁₈O₆)  ·  C₁₀H₁₄O  ·  C₆H₁₂O₆.
         polychroit     crocin    essential oil   sugar

_Crocin_ is a red powder, insoluble in ether, easily soluble in
alcohol, and precipitable from this solution on addition of ether.
It is only slightly soluble in water, but freely in an alkaline
solution, from which an acid precipitates it in purple-red flecks.
Strong sulphuric and nitric acids occasion the same colours as with
polychroit; the former producing deep blue, changing to violet
and brown, and the latter green, yellow, and finally brown. It is
remarkable that hydrocarbons of the benzol class do not dissolve the
colouring matter of saffron.

The oil obtained by decomposing crocin is heavier than water; it boils
at about 209° C., and is easily altered,—even by water. It is probably
identical with the volatile oil obtainable to the extent of one per
cent. from the drug itself, and to which its odour is due.

Saffron contains sugar (glucose?), besides that obtained by the
decomposition of polychroit. The drug leaves after incineration 5 to 6
per cent. of ash.

=Production and Commerce=—In France the cultivation is carried on by
small peasant proprietors; the flowers are collected at the end of
September or in the beginning of October. The stigmas are quickly taken
out, and immediately dried on sieves over a gentle fire, to which they
are exposed for only half an hour. According to Dumesnil[2490] 7,000 to
8,000 flowers are required for yielding 500 grammes (17½ oz.) of fresh
saffron, which by drying is reduced to 100 grammes.

Notwithstanding the high price of saffron, its cultivation is by no
means always profitable, from the many difficulties by which it is
attended. Besides occasional injury from weather, the bulbs are often
damaged by parasitic fungi as stated by Duhamel in 1728[2491] and again
by Montagne in 1848.[2492]

[2489] Wiggers and Husemann, _Jahresbericht_ for 1868. 35.

[2490] _Bulletin de la Société impériale d’acclimatation_, Avril, 1869.

[2491] _Mém. de l’Acad. des Sciences_, 1728. p. 100.

[2492] _Etude micrographique de la maladie du Safran, connue sous le
nom de tacon._

The most considerable quantity of saffron is now produced in Spain,
namely in Lower Arragon, in Novelda near Alicante, in the province
Albacete (Northern Murcia), in La Mancha, near Huelva, and also near
Palma in the island of Mallorca. It is brought into commerce as
_Alicante_ and _Valencia Saffron_. The quantity of saffron exported
from Spain in 1864 was valued at £190,062; in 1865, £135,316; in 1866,
£47,083. The drug was chiefly exported to France.[2493]

French saffron, which enjoys a better reputation for purity than the
Spanish, is cultivated in the arrondissement of Pithiviers-en-Gâtinais,
in the department of the Loiret, which district annually furnishes a
quantity valued at 1,500,000 (£60,000) to 1,800,000 francs.[2494] The
exports of France in 1875 were 97,021 kilogrammes, 84,337 of which
being imported from Spain.

In Austria, Maissau, north-east of Krems on the Danube, still
produces excellent saffron, though only to a very small extent; the
district was formerly celebrated for the drug. Saffron is produced in
considerable quantity in Ghayn, an elevated mountain region separating
Western Afghanistan from Persia.[2495] A very little of inferior
quality is collected at Pampur in Kashmír, under heavy imposts of
the Maharaja.[2496] Saffron is also cultivated in some districts of
China. Finally, the cultivation has been introduced into the United
States, and a little saffron is collected by the German inhabitants of
Lancaster County, Pennsylvania.[2497] But in almost all countries the
cultivation of saffron is on the decline, and in very many districts
has altogether ceased.

The imports of saffron into the United Kingdom amounted in 1870 to
43,950 lb., valued at £95,690. The article is largely exported to
India, but there are no general statistics to show the amount. Bombay
imported in the year 1872-73, 21,994 lb., value £35,115.[2498] It is a
curious fact that now Spanish saffron finds regularly its way to India.

=Uses=—Saffron is of no value for any medicinal effects, and retains
a place in the pharmacopœia solely on the ground of its utility as a
colouring agent. A peculiar preference for it as a condiment exists
in various countries, but especially in Austria, Germany and some
districts of Switzerland. This predilection prevails even in England—at
least in Cornwall, where the use of saffron for colouring cakes is
still common. Saffron is largely used by the natives of India in
religious rites, in medicine and for the colouring and flavouring of
food.

As a dye-stuff saffron is no longer employed, at least in this country,
its use having been superseded by less costly substances.

=Adulteration=—Saffron is often adulterated, but the frauds practised
on it are not difficult of detection. Sometimes the falsification
consists in the addition of florets of _Calendula_ dyed with logwood,
or of safflower, or the _stamens_ of the saffron crocus, any of which
may be detected if a small pinch of the drug be dropped on the surface
of warm water, when the peculiar form of the saffron stigma will at
once become evident.

[2493] _Statistical Tables relating to Foreign Countries_ (Blue Book)
1870. 286. 289.

[2494] Dumesnil, _l. c._

[2495] Bellew, _From the Indus to the Tigris_, Lond. 1874. 304.

[2496] Hügel, _Kaschmir_, ii. (1840) 274.—Powell, _Punjab Products_, i.
(1868) 449.—_Pharm. Journ._ vi. (1875) 279.

[2497] _Proc. of the American Pharm. Assoc._ 1866. 254.

[2498] _Annual Statement of the Trade and Navigation of the Presidency
of Bombay for 1872-73._ pt. ii. 30.

Another adulteration of late much practised, and not always easy to
detect by the eye, consists in coating genuine saffron with carbonate
of lime, previously tinged orange-red. If a few shreds of such saffron
be placed on the surface of water in a wineglass and gently stirred,
the water will _immediately_ become turbid, and the carbonate of
lime will detach itself as a white powder and subside. Saffron thus
adulterated will _freely effervesce_ when dilute hydrochloric acid is
dropped upon it. We have examined Alicante Saffron, the weight of which
had been increased more than 20 per cent. by this fraudulent admixture.
The earthy matter employed in sophisticating saffron is said to be
sometimes emery powder, rendered adherent by honey. We have found that
adulterated with carbonate of lime to leave from 12 to 28 per cent. of
ash.[2499]




PALMÆ.


SEMEN ARECÆ.

_Nuces Arecæ vel Betel_; _Areca Nuts_, _Betel Nuts_; F. _Semence ou
Noix d’Arec_; G. _Arekanüsse_, _Betelnüsse_.

=Botanical Origin=—_Areca Catechu_ L., a most elegant palm,[2500] with
a straight smooth trunk, 40 to 50 feet high and about 20 inches in
circumference. The inflorescence is arranged on a branching spadix,
with the male flowers on its upper portion and the female near its
base. The tree is cultivated in the Malayan Archipelago, the warmer
parts of the Indian Peninsula, Ceylon, Indo-China and the Phillippines.
It is probably indigenous to the first-named region.

=History=—The Areca palm is mentioned in the Sanskrit writings as
_Guvāca_. It is called in Chinese _Pin-lang_, a name apparently derived
from _Pinang_, a designation for the tree in the Malay Islands, whence
the Chinese anciently derived their supply of the seeds. The oldest
Chinese work to mention the _pin-lang_ is the _San-fu-huang-tu_, a
description of Chang-an, the capital of the Emperor Wu-ti, B.C. 140-86.
It is there stated that after the conquest of Yunnan, B.C. 111, some
remarkable trees and plants of the south were taken to the capital, and
among them more than 100 _pin-lang_, which were planted in the imperial
gardens. Bretschneider,[2501] to whose researches we are indebted for
this information, cites several other Chinese works, from the first
century downwards, showing that areca nuts were brought from the then
unsubdued provinces of Southern China, the Malayan Archipelago and
India. The custom of presenting areca nut to a guest is alluded to in a
work of the 4th century.

[2499] _Science Papers_, 368.

[2500] Bentley and Trimen, _Medic. Plants_, part 21 (1877).

[2501] _On the study of Chinese botanical works_, Foochow, 1870. 27.

The Arabian writers, as for instance Ibn Batuta, were well acquainted
with the areca nut, which they called _Fófal_, and with the Indian
custom of masticating it with lime.

Areca nut, though held in great estimation among Asiatics as a
masticatory, and supposed to strengthen the gums, sweeten the breath
and improve digestion, has not until recently been regarded as
possessing any particular medicinal powers beyond those of a mild
astringent.[2502] It has often been administered as a vermifuge to
dogs, and in India and China is given with the same intent to the human
subject. Some successful trials recently made of it for the expulsion
of tapeworm have led to it being included in the _Additions to the
British Pharmacopœia of 1867_, published in 1874.

=Description=—The areca palm produces a smooth ovoid fruit, of the
size of a small hen’s egg, slightly pointed at its upper end, and
crowned with the remains of the stigmas. Its exterior consists of a
thick pericarp, at first fleshy, but, when quite mature, composed of
fine stringy fibres running lengthwise, with much coarser ones below
them. This fibrous coat is consolidated into a thin crustaceous shell
or endocarp, which surrounds the solitary seed. The latter has the
shape of a very short rounded cone, scarcely an inch in height; it
is depressed at the centre of the base, and has frequently a tuft of
fibres on one side of the depression, indicating its connexion with
the pericarp. The testa, which seems to be partially adherent to the
endocarp, is obscurely defined, and inseparable from the nucleus.
Its surface is conspicuously marked with a network of veins, running
chiefly from the hilum. When a seed is split open, it is seen that
these veins extend downwards into the white albumen, reaching almost to
its centre, thus giving the seed a strong resemblance both in structure
and appearance to a nutmeg. The embryo, which is small and conical, is
seated at the base of the seed. Areca nuts are dense and ponderous, and
very difficult to break or cut. They have when freshly broken a weak
cheesy odour, and taste slightly astringent.

=Microscopic Structure=—The white horny albumen is made up of large
thick-walled cells, loaded with an albuminoid matter, which on addition
of iodine assumes a brown hue. The cell-walls display large pores,
the structure of which, after boiling in caustic ley, becomes clearly
evident in polarized light. The brown tissue which runs into the
albumen is of loose texture, and resembles the corresponding structure
in a nutmeg. The thin walls of its cells are marked with fine spiral
striations, and in this tissue, as well as on the brown surface of the
seed, delicate spiral vessels are scattered. All the brown cells assume
a rich red if moistened with caustic ley, and a dingy green with ferric
chloride.

=Chemical Composition=—We have exhausted the powder of the seeds,
previously dried at 100° C., with ether; and thereby obtained a
_colourless_ solution, which after evaporation left an oily liquid,
concreting on cooling. This fatty matter, representing 14 per cent.
of the seed, was thoroughly crystalline and melted at 39° C. By
saponification we obtained from it a crystalline fatty acid fusing at
41° C., which may consequently be a mixture of lauric and myristic
acids. Some of the fatty matter was boiled with water: the water
on evaporation afforded an extremely small trace of tannin but no
crystals, which had catechin been present should have been left.

[2502] J. J. Berlu, _The Treasury of Drugs Unlocked_, London, 1724, no
doubt had before him the areca nuts in speaking of “_Nuces indicæ_ (see
also p. 503, note 2), like a nutmeg in shape, in chewing turns red; it
is said they will make one drunk ... but I could never find it.”

The powdered seeds which had been treated with ether were then
exhausted by cold spirit of wine (·832), which afforded 14·77 per
cent. (reckoned on the original seeds) of a red amorphous _tannic
matter_, which after drying, proved to be but little soluble in water,
whether cold or boiling. Submitting to destructive distillation, it
afforded _Pyrocatechin_. Its aqueous solution is not altered by ferrous
sulphate, unless an alkali is added, when it assumes a violet hue, with
separation of a copious dark purplish precipitate. On addition of a
ferric salt in minute quantity to the aqueous solution of the tannic
matter, a fine green tint is produced, quickly turning brown by a
further addition of the test, and violet by an alkali. An abundant dark
precipitate is also formed.

The seeds having been exhausted by both ether and spirit of wine,
were treated with water, which removed from them chiefly mucilage
precipitable by alcohol. The alcohol thus used afforded on filtration
traces of an acid, the examination of which was not pursued. After
exhaustion with ether, spirit of wine and water, a dark brown solution
is got by digesting the residue in ammonia: from this solution, an
acid throws down an abundant brown precipitate, not soluble even in
boiling alcohol. We have not been able to obtain crystals from an
aqueous decoction of the seeds, nor by exhausting them directly with
boiling spirit of wine. We have come therefore to the conclusion that
_Catechin_ (p. 243) is not a constituent of areca nuts, and that any
extract, if ever made from them, must be essentially different to the
_Catechu of Acacia_ or of _Nauclea_, and rather to be considered a kind
of tannic matter of the nature of _Ratanhia-red_ or _Cinchona-red_.

By incinerating the powdered seeds, 2·26 per cent. were obtained of
a brown ash, which, besides peroxide of iron, contained phosphate of
magnesium.

=Commerce=—Areca nuts are sold in India both in the husk (pericarp)
and without it, and the two sorts are enumerated in the Customs
Returns under distinct heads. Their widespread consumption in the East
gives rise to an enormous trade, of which some notion may be formed
by a consideration of the few statistics bearing upon it which are
accessible.

Thus, Ceylon exported of areca nuts in the year 1871, 66,543 cwt.,
value £62,593; in 1872, 71,715 cwt.,—the latter quantity entirely to
India; in 1875 of the total export of 94,567 cwt. 86,446 were shipped
to India.[2503]

The Madras Presidency largely trades in the same commodity. In the year
1872-1873 there were shipped thence to Bombay 43,958 cwt., besides
about two millions of the entire fruit.[2504] An extensive traffic in
areca nuts is carried on at Singapore and especially in Sumatra.

=Uses=—Powdered areca nut may be given for the expulsion of tapeworm
in the dose of 4 to 6 drachms, taken in milk. The remedy should be
administered to the patient after a fast of about twelve hours; some
recommend the previous exhibition of a purgative. It is said to be
efficacious against _lumbricus_ as well as _tænia_.

The charcoal afforded by burning areca nuts in a close vessel is
sold as a tooth powder; but except greater density, it possesses no
advantage over the charcoal from ordinary wood.

[2503] Ceylon Blue Books.

[2504] From the returns quoted at p. 571, note 5.

As a masticatory areca nut is chewed with a little lime and a leaf of
the Betel Pepper, _Piper Betle_ L. The nut for this purpose is used in
a young and tender state, or is prepared by boiling in water; it is
sometimes combined with aromatics, as camphor or cardamom.


SANGUIS DRACONIS.

_Resina Draconis_; _Dragons Blood_; F. _Sang-dragon_; G. _Drachenblut_.

=Botanical Origin=—_Calamus Draco_[2505] Willd. (_Dæmonorhops Draco_
Mart.)—This is one of the Rotang or Rattan Palms, remarkable for their
very long flexible stems, which climb among the branches of trees by
means of spines on the leafstalk. The species under notice, called in
Malay _Rotang Jernang_, grows in swampy forests of the Residency of
Palembang and in the territory of Jambi, in Eastern Sumatra, and in
Southern Borneo, which regions furnish the dragon’s blood of commerce.
It is said to occur also in Penang and in various islands of the Sunda
chain.

=History=—The substance which is mentioned by Dioscorides under the
name of Κιννάβαρι, as a costly pigment and medicine brought from
Africa, and which is also described by Pliny who distinguished it from
minium, was certainly the resin called _Dragon’s Blood_. It was not
however that of the Rotang Palm, _Calamus Draco_, or even of any tree
of the Indian Archipelago, but was on the contrary a production of the
island of Socotra (see p. 675).

Dragon’s blood is, we believe, not named by any of the earlier voyagers
to the India islands. Ibn Batuta, who visited both Java and Sumatra
between A.D. 1325 and 1349, and notices their producing benzoin (see
p. 404), cloves, camphor, and aloes-wood, is silent about dragon’s
blood. Barbosa, whose intelligent narrative (A.D. 1514) of the East
Indies[2506] is full of reference to the trade and productions of the
different localities he visited, states that aloes and _dragon’s blood_
are produced in Socotra, but makes no mention of the latter commodity
as found at Malacca, Java, Sumatra, or Borneo.

The fact we wish to prove is corroborated by the accounts of early
commercial intercourse between the Chinese and Arabs recently published
by Bretschneider.[2507] From the 10th to the 15th century there was
carried on between these nations a trade, the objects of which were not
only the productions of the Arabian Gulf and countries further north,
but also those of the Indian Archipelago. One of the islands with which
the Arabs and Persians carried on a great commerce was Sumatra, whence
they obtained the precious camphor so much valued by the Chinese,
but not, so far as it appears, the resin dragon’s blood. As to the
productions brought from Arabia they are enumerated as Ostriches,
Olibanum, Liquid Storax, Myrrh, and _Dragon’s Blood_, besides a few
other articles not yet determined. It is worthy of remark that the
Chinese are still the principal consumers of dragon’s blood, though
like the rest of mankind they have to content themselves with the
plentiful drug of Sumatra and Borneo, instead of the more ancient sort
produced in Socotra.

[2505] Beautifully figured by Blume, _Rumphia_, ii. (1836) tab. 131-132.

[2506] _Description of the Coasts of East Africa and Malabar_ (Hakluyt
Society), 1866. 30. 191-197.

[2507] _Knowledge possessed by the Chinese of the Arabs, etc._, 1871.

The first clear account of the production of the resin in India is that
given by Rumphius, who in his _Herbarium Amboinense_[2508] describes
the process by which it is collected at Palembang.

=Production=—The fruit of _Calamus Draco_, which is produced in
panicles in great profusion, is globose and of the size of a large
cherry, clothed with smoothed downward-overlapping scales. These scales
are sub-quadrangular, thick and shell-like, marked with a longitudinal
furrow; the largest, which are found towards the middle of the fruit,
are 2 lines long by 3 broad. At maturity the fruit is covered with an
exudation of red resin, which encrusts it so abundantly that the form
of the scales can hardly be seen.

The resin, which is naturally friable, is collected by gathering the
fruits, and shaking or beating them in a sack, by which process it
is soon separated. It is then sifted to remove from it scales and
other portions of the fruit. By exposure to the heat of the sun or
in a covered vessel to that of boiling water, the resin is so far
softened that it can be moulded into sticks or balls, which are
forthwith wrapped in a piece of palm leaf. It is thus that the best
dragon’s blood, or _jernang_, is obtained. An inferior quality is got
by boiling the pounded fruits in water, and making the resin into
a mass, frequently with the addition of other substances by way of
adulteration. The foregoing is the account of the manufacture of the
drug given by Blume.[2509]

[2508] Pars. v. (1747) 114-115. tab. 58.

[2509] _Rumphia_, iii. (1847) 9. tab. 131. 132.

=Description=—Dragon’s Blood is found in commerce chiefly in two forms,
known respectively as _Reed_ and _Lump_.

1. _Reed Dragon’s Blood_ (Dragon’s Blood in sticks, _Sanguis draconis
in baculis_). Some of fine quality purchased in London in 1842 is
in sticks 13 to 14 inches in length, and ¾ to 1 inch in diameter,
neatly wrapped in palm leaf, secured by 8 or 9 transverse bands of
some flexible grass. The average weight of each stick, including
the enveloping leaf, is five ounces. The resin has evidently been
wrapt up while soft, as the sticks are furrowed longitudinally
by pressure of the surrounding leaf. The smooth surface is of an
intense blackish-brown; when seen in thin splinters the resin appears
transparent, and of a pure and brilliant crimson. The fractured surface
looks resinous and rough, is a little porous, and contains numerous
particles of the scales of the fruit. Rubbed on paper it leaves a red
mark of not very splendid tint. Heated with alcohol it left 20 per
cent. of pulverulent residue consisting chiefly of vegetable matter.
Sticks of smaller size are more common.

2. _Lump Dragon’s Blood_ (_Sanguis draconis in massis_) is imported
in large rectangular blocks or irregular masses. From the fine _Reed
Dragon’s Blood_, just described, it differs in containing a larger
proportion of remains of the fruit, including numerous entire scales.
Hence it has a coarser fracture, and the fractured surface is less
intense in tint. Its taste is slightly acrid. Exhausted with alcohol it
leaves a residue amounting in the specimen we tested to 27 per cent.

Dragon’s blood is abundantly soluble in the usual solvents of resins,
namely, the alcohols (even in dilute spirit of wine), benzol,
chloroform, bisulphide of carbon, and the oxygenated essential oils,
as that of cloves. The residue left after the evaporation of these
liquids is amorphous and of the original fine red colour. The drug is
likewise dissolved by glacial acetic acid as well as by caustic soda;
the latter solution on addition of an excess of acid yields a dingy
brown, jelly-like precipitate, which on drying turns dark red like
the original drug. In ether dragon’s blood is sparingly soluble, and
still less so in oil of turpentine; but in the most volatile portions
of petroleum, the so-called petroleum ether we find it to be entirely
insoluble. It has a slightly sweetish and somewhat acrid taste; melts
at about 120° C., evolving the aromatic but irritating fumes of benzoic
acid; boiled with water the resin becomes soft and partially liquid.

=Chemical Composition=—Dragon’s blood is a peculiar resin, which
according to Johnston[2510] answers to the formula C₂₀H₂₀O₄. By heating
it and condensing the vapour an aqueous acid liquid is obtained,
together with a heavy oily portion of a pungent burning taste and
crystals of benzoic acid. The composition of these products has not yet
been thoroughly ascertained, but the presence of acetone, _Toluol_,
C₆H₅(CH₃), _Dracyl_ of Glénard and Boudault (1844), and _Styrol_,
C₈H₈ (_Draconyl_), has been pointed out,[2511] the latter perhaps due
to the existence in the drug of metastyrol (p. 274), as suggested by
Kovalewsky.[2512] Both these hydrocarbons are _lighter_ than water; yet
we find that the above oily portion yielded by dry distillation sinks
in water, a circumstance possibly occasioned by the presence of benzoic
alcohol, C₆H₅(CH₂OH).

As benzoic acid is freely soluble in petroleum ether it ought to be
removed from the drug by that solvent: on making the experiment we
got traces of an amorphous red matter, a little of an oily liquid,
but nothing crystalline. Cinnamic acid, on the other hand, is always
present, according to Hirschsohn (1877). As to the watery liquid, it
assumes a blue colour on addition of perchloride of iron, whence it
would appear to contain phenol or pyrogallol rather than pyrocatechin
(p. 196).

By boiling dragon’s blood with nitric acid, benzoic, nitro-benzoic, and
oxalic acids are chiefly obtained, and only very little picric acid.
_Hlasiwetz_ and _Barth_ melted the drug with caustic potash, and found
among the products thus formed phloroglucin (p. 243), para-oxybenzoic,
protocatechuic, and oxalic acids, as well as several acids of the fatty
series. Benzoin yields similar products.

=Commerce=—Dragon’s blood is shipped from Singapore and Batavia. Large
quantities are annually exported from Banjarmasin in Borneo to these
places and to China.[2513]

=Uses=—In medicine, only as the colouring agent of plasters and tooth
powders; in the arts, for varnish.

=Adulteration=—Dragon’s blood varies exceedingly in quality,[2514] of
which the principal criterion regarded by the dealers is _colour_. Some
of the inferior sorts make only a dull brick-red mark when rubbed on
paper, and have an earthy-looking fracture. The sticks moreover do not
take the impression of the enveloping leaf as when they are more purely
resinous. A sample of inferior Reed Dragon’s Blood afforded us 40 per
cent. of matter, insoluble in spirit of wine.

[2510] _Phil. Trans._ 1839. 134; 1840. 384.

[2511] Gmelin, _Chemistry_, xvii. (1866) 387.

[2512] Gmelin, _Chemistry_, xvii. 388; also _Annalen der Chemie_, cxx.
(1861) 68.

[2513] Low, _Sarawak, its inhabitants and productions_, 1848. 43.

[2514] The present price, £3 to £11 per cwt., sufficiently indicates
this.

Other sorts of Dragon’s Blood.

_Dragon’s Blood of Socotra_—We have already stated (p. 672) that the
_Cinnabar_ mentioned by Dioscorides was brought from Africa. That the
term really designated dragon’s blood seems evident from the fact that
the author of the Periplus of the Erythrean Sea,[2515] written _circa_
A.D. 54-68, names it (Κιννάβαρι) as a production of the island of
Dioscorida, the ancient name of Socotra.

The Arabians, as Abu Hanifa and Ibn Baytar,[2516] describe dragon’s
blood as brought from Socotra, giving to the drug the very name
by which it is known to the Arabs at the present day, namely,
_Dam-ul-akh-wain_. Barbosa (1514) as well as Giovanni di Barros[2517]
mention it as a production of the island; and in our own times it
has been noticed by Wellstead,[2518] Vaughan,[2519] and A. von
Kremer.[2520] It is now but little collected. Vaughan states, as well
as Von Wrede, that the tree is found in Hadramaut and on the east coast
of Africa. The latter statement is also made in letters (1877, 1878),
with which we were favoured by Captain Hunter of Aden and Hildebrandt
of Berlin (see pages 140 and 141), by the latter of whom we were
presented with a photographic sketch of the tree growing in the Somali
country, at elevations of from 2500 to 5500 feet, and called there
Moli. It is _Dracæna schizantha_ Baker,[2521] a tree attaining 8 metres
in height. The resin has an acidulous taste, and is, according to
Hildebrandt, not exported, but occasionally eaten by the Somalis. The
tree from which dragon’s blood is collected in Socotra is, according to
Capt. Hunter, _Dracæna Ombet_ Kotschy.

The _Drop Dragon’s Blood_, of which small parcels imported from Bombay
or Zanzibar occasionally appear in the London market, is however this
drug. It is in small tears and fragments, seldom exceeding an inch in
length, has a clean glassy fracture, and in thin pieces is transparent
and of a splendid ruby colour. From Sumatran dragon’s blood it may be
distinguished by not containing the little shell-like scales constantly
present in that drug, and by not evolving when heated on the point of a
knife the irritating fumes of benzoic acid.

_Dragon’s Blood of the Canary Islands_—This substance is afforded by
_Dracæna Draco_ L., a liliaceous tree[2522] resembling a _Yucca_,
of which the famous specimen at Orotava in Teneriffe has often been
described on account of its gigantic dimensions and venerable age.[2523]

[2515] _Voyage of Nearchus and Periplus of the Erythrean Sea_,
translated by Vincent, Oxford, 1809. 90.

[2516] Sontheimer’s ed. i. 104. 426. ii. 117.

[2517] _L’Asia_, sec. deca. Venet. 1561. p. 10. a.

[2518] _Travels in Arabia_, Lond. 1838. ii. 449.

[2519] _Pharm. Journ._ xii. (1853) 385.

[2520] _Aegypten_, Leipzig, 1863.

[2521] On Hildebrandt’s East African Plants, _Journ. of Bot._ xv.
(1877) 71.

[2522] Histological observations on the structure of the stem,
accompanied by excellent figures, will be found in a memoir by
Rauwenhoff (_Bijdrage tot de kennis van Dracæna Draco_, pp. 55. tabb.
5) in the _Verhand. d. Kon. Acad. v. Wetensch., afd. Natuurk_. x. 1863.

[2523] It was destroyed in 1867 by a hurricane.

On the exploration of Madeira and Porto Santo in the 15th century,
dragon’s blood was one of the valued productions collected by the
voyagers, and is named as such by Alvise da ca da Mosto in 1454.[2524]
It is also mentioned by the German physician Hieronymus Münzer, who
visited Lisbon about 1494.[2525]

The tree yields the resin after incisions are made in its stem; but so
far as we know the exudation has never formed a regular and ordinary
article of commerce with Europe. It has been found in the sepulchral
caves of the aboriginal inhabitants.

The name _Dragon’s Blood_ has also been applied to an exudation
obtained from the West Indian _Pterocarpus Draco_ L., and to that of
_Croton Draco_ Schlecht.; but the latter appears to be of the nature of
kino, and neither substance is met with in European commerce.




AROIDEÆ.


RHIZOMA CALAMI AROMATICI.

_Radix Calami aromatici_, _Radix Acori_; _Sweet Flag Root_; F. _Acore
odorant ou vrai_, _Roseau aromatique_; G. _Kalmus_.

=Botanical Origin=—_Acorus Calamus_ L., an aromatic, flag-like plant,
growing on the margins of streams, swamps, and lakes, from the coasts
of the Black Sea, through Southern Siberia, Central Asia, and India, as
far as Amurland, Northern China, and Japan; indigenous also to North
America. It is now established as a wild plant in the greater part of
Europe, reaching from Sicily as far north as Scotland, Scandinavia,
and Northern Russia; and is cultivated to a small extent in Burma and
Ceylon.

Regarding the introduction of _Acorus Calamus_ into Western Europe, it
is believed in Poland to have been introduced there in the 13th century
by the Tartars, yet it seems not to have attracted then any attention.
The well-informed botanist, Bock (Tragus), mentioning the use of the
preserved rhizome by wealthy persons, states[2526] that he had never
seen the plant growing in Germany. Clusius[2527] relates that he first
received a living plant in 1574, sent from the lake Apollonia near
Brussa in Asia Minor. Camerarius,[2528] writing in 1588, speaks of it
as introduced some years previously, and then plentiful in Germany,
which seems to show a rapid propagation. Gerarde at the close of the
century looked upon _Acorus_ as an Eastern plant, which he says is
grown in many English gardens, and might hence be fitly called the
“_Sweet Garden Flag_.” Berlu,[2529] in 1724, observes of the root
that—“_it is brought in quantities from Germany_:” hence we may infer
that it was not then collected in England, as we know it was at a later
period.[2530]

[2524] Ramusio, _Raccolta delle Navigationi et Viaggi_, Venet. i. 97.

[2525] Kunstmann, _Abhandlungen der Baierischen Akademie der
Wissenschaften_, vii. (1855) 342. et seq.

[2526] _Teutsche Speiskammer_, Strassburg, 1550. ciiii.

[2527] _Rariorum Stirpium Historia_, Antv. 1576. 520.

[2528] _Hortus medicus et philosophicus_, Francof. 1588. 5.

[2529] _Treasury of Drugs_, ed. ii. 1724. 115.

[2530] See also Trimen in _Journ. of Botany_, ix. (1871) 163.

=History=—Sweet Flag root has been from the earliest times a favourite
medicine of the natives of India, in which country it is sold in every
bazaar. Ainslie[2531] asserts that it is reckoned so valuable in the
bowel complaints of children that there is a penalty incurred by any
druggist who will not open his door in the middle of the night to sell
it, if demanded!

The descriptions of _Acoron_, a plant of Colchis, Galatia, Pontus, and
Crete, given by Dioscorides and Pliny, certainly refer to this drug. We
think that the Κάλαμος ἀρωματικός of Dioscorides, which he states to
grow in India, is the same, though Royle regards it as an _Andropogon_.
The Κάλαμος of Theophrastus and the _Calamus_ of the English
Bible[2532] are considered by some authors to refer to the Sweet Flag.

Celsus in the first century mentioned _Calamus Alexandrinus_, the drug
being probably then brought from India by way of the Red Sea. We know
by the testimony of Amatus Lusitanus[2533] that in the 16th century it
used to be so imported into Venice. Rheede,[2534] moreover, described
and figured _Acorus Calamus_ as an Indian plant under the name _Vacha_,
which it still bears on the Malabar Coast. But in the pharmaceutical
tariff of the German town of Halberstadt of the year 1697, “_Calamus
aromaticus verus, Indianischer Calmus_” and “_Calamus aromaticus
nostras_,” _common Calmus_, are quoted at exactly the same price,[2535]
and Murray[2536] states expressly that in his time (1790) Asiatic
calamus was still met with in the pharmacies of Continental Europe, but
that it had mostly been replaced by the home-grown drug. At the present
time the _Calamus aromaticus_ of commerce is European; in all essential
characters it agrees with that of India, a package of which is now and
then offered in the London drug sales.

=Collection=—The London market is supplied from Germany, whither the
drug is brought, we believe, from Southern Russia. It is no longer
collected in England,—at least in quantity, though it used to be
gathered some years ago in Norfolk.

=Description=—The rootstock of sweet flag occurs in somewhat tortuous,
subcylindrical or flattened pieces, a few inches long, and from ½ to
1 inch in greatest diameter. Each piece is obscurely marked on the
upper surface with the scars, often hairy, of leaves, and on the under
with a zigzag line of little, elevated, dot-like rings,—the scars of
roots. The rootstock is usually rough and shrunken, varying in colour
from dark brown to orange-brown, breaking easily with a short corky
fracture, and exhibiting a pale brown spongy interior. The odour is
aromatic and agreeable; the taste, bitterish and pungent.

The fresh rootstock is brownish-red or greenish, white or reddish
within, and of a spongy texture. Its transverse section is tolerably
uniform; a fine line (medullary sheath) separates the outer tissue from
the lighter central part, the diameter of which is twice or three times
the width of the former.

[2531] _Mat. Med. of Hindoostan_, Madras, 1813. 54.

[2532] Exod. xxx. 23; Cant. iv. 14; Ezek. xxvii. 19.—See also page 715,
footnote 2.

[2533] _In Diosc. de Mat. Med. Enarrationes_, Argent. 1554. 33.

[2534] _Hortus Malabar_, xi (1692) tab. 48. 49.

[2535] Flückiger, _Documente_ (quoted page 562), 78.

[2536] _Apparatus Medicaminum_, v. 40.

=Microscopic Structure=—The outermost layer is made up of extended
epiblema-cells or of a brown corky tissue, the latter occurring in
the parts free from leaf-scars. The prevailing tissue, both of the
outer and the central part, consists of uniform nearly globular cells,
traversed by numerous vascular bundles, especially at the boundary
line (medullary sheath). Besides them, the rootstock like that of
many fresh-water plants, exhibits a large number of intercellular
holes. These air-holes, or more correctly water-holes, are somewhat
longitudinally extended, so as to form a kind of network, imparting a
spongy consistence[2537] to the fresh rootstock. At certain places,
where the series of cells cross one another, especially in the outer
part, there are single cells filled with essential oil,[2538] which
may be made very conspicuous by adding to sections dilute potash or
perchloride of iron. The other cells are loaded with small starch
granules; a little mucilage and tannic matter is met with in the
exterior coat.

=Chemical Composition=—The dried rhizome yielded us 1·3 per cent. of a
yellowish neutral essential oil of agreeable odour, which in a column
of 50 mm. long, deviates 13·8° to the right. By working on a large
scale, Messrs. Schimmel & Co., Leipzig, obtain 2·4 to 2·6 per cent.

According to Kurbatow (1873), this oil contains a hydrocarbon,
C₁₀H₁₆, boiling at 159° C., and forming a crystalline compound with
HCl, and another hydrocarbon boiling at 255-258° C., affording no
crystallizable hydrochloric compound. By submitting the oil to
fractional distillation, we noticed, above 250°, a blue portion, which
may be decolorized by sodium. The crude oil acquires a dark brownish
colour on addition of perchloride of iron, but is not at all soluble in
concentrated potash solution.

The bitter principle _Acorin_ was extracted by Faust in 1867, as a
semi-fluid, brownish glucoside, containing nitrogen, soluble both
in ether and in alcohol, but neither in benzol nor in water. In
order to obtain this substance, we precipitated the decoction of 10
lb. of the drug by means of tannic acid, and followed the method
commonly practised in the preparation of bitter principles. By finally
exhausting the residue with chloroform, we succeeded in obtaining a
very bitter, perfectly crystalline body, but in so minute a quantity,
that we were unable to investigate its nature.

=Uses=—Sweet Flag is an aromatic stimulant and tonic, now rarely used
in regular medicine. It is sold by the herbalist for flavouring beer,
and for masticating to clear the voice. It is said to be also used by
snuff manufacturers.

=Adulteration=—The rhizome of the Yellow Flag, _Iris Pseudacorus_ L.,
is occasionally mixed with that of the Sweet Flag, from which it may be
distinguished by its want of aroma, astringent taste, dark colour, and
dissimilar structure.

[2537] This was possibly alluded to by Albertus Magnus (A.D.
1193-1280), who says:—(Calamus aromaticus)—nascitur in India et
Ethiopia sub cancro, et habet interius ex parte concava “pellem
subtilem, _sicut telæ sunt aranearum_.”—_De Vegetabilibus_, Jessen’s
ed. 1867. 376. We suppose the drug under notice was intended.

[2538] Hence the practice of _peeling_ the rhizome which prevails in
some parts of the Continent ought to be abandoned.




LILIACEÆ.


ALOË.

_Aloes_; F. _Aloès ou Suc d’Aloès_; G. _Aloë_.

=Botanical Origin=—Several species of _Aloë_[2539] furnish a bitter
juice which when inspissated forms this drug. These plants are natives
of arid, sunny places in Southern and Eastern Africa, whence a few
species have been introduced into Northern Africa, Spain,[2540] and the
East and West Indies.

The aloes are succulent plants of liliaceous habit with persistent
fleshy leaves, usually prickly at the margin, and erect spikes of
yellow or red flowers. Many are stemless; others produce stems some
feet in height, which are woody and branching. In the remote districts
of Namaqua Land and Damara Land in Western South Africa, and in the
Transkei Territory and Northern Natal to the eastern, aloes have been
discovered which attain 30 to 60 feet in height, with stems as much as
12 feet in circumference.[2541] The following species may be named with
more or less of certainty as yielding the drug.[2542]

_Aloë socotrina_ Lam. (_A. vera_ Miller), native of the southern shores
of the Red Sea and Indian Ocean, Socotra, and Zanzibar (?). It is the
source of the _Socotrine_ and _Moka Aloes_. _A. officinalis_ Forsk. and
_A. rubescens_ DC. are considered to be varieties of this plant. _A.
abyssinica_ Lam. may probably contribute to the aloes shipped from the
Red Sea.

_A. vulgaris_ Lam. _A. perfoliata_, var. π. _vera_ Linn., _A.
barbadensis_ Mill., a plant of India and of Eastern and Northern
Africa, now found also on the shores of Southern Spain, Sicily, Greece,
and the Canaries; introduced in the beginning of the 16th century (or
earlier) into the West Indies. It affords _Barbados_ and _Curaçao
Aloes_. _A. indica_ Royle, a plant of the North-west Provinces of
India, common in Indian gardens, appears to be a slight variety of
_A. vulgaris_ Lam. _A. litoralis_ König, said to grow in abundance
at Cape Comorin, is unknown to us. Dr. Bidie suggests that it is a
form of the preceding, stunted by a poor saline soil and exposure to
the sea breeze. Both _A. indica_ and _A. litoralis_ are named in the
_Pharmacopœia of India_.

_Aloë ferox_ L., and hybrids obtained by crossing it with _A. africana_
Mill. and _A. spicata_ Thunberg, _A. perfoliata_ Linn. (_quoad_ Roxb.)
and _A. linguæformis_ are reputed to yield the best _Cape Aloes_.

_A. africana_ Mill. and its varieties, and _A. plicatilis_ Mill. afford
an extract which Pappe[2543] says is thought to be less powerful.

[2539] From the Syriac _Alwai_.

[2540] _Aloë arborescens_, _A. purpurascens_, and _A. vulgaris_ may be
seen luxuriantly growing in Valencia, Granada, Gibraltar.

[2541] Dyer in _Gardeners’ Chronicle_, May 2, 1874, with figures.

[2542] Good figures of _Aloë africana_, _A. arborescens_, _A. ferox_,
_A. purpurascens_, _A. socotrina_, and _A. vulgaris_ will be found in
the work _Monographia generis Aloës et Mesembryanthemi_, auctore Jos.
Principe de Salm-Reifferscheid-Dyck, Bonnae, 1836-1863. fol.

[2543] _Floræ Capensis Medicæ Prodromus_, ed. 2, 1857. 41.

_A. arborescens_ Mill., _A. Commelini_ Willd. and _A. purpurascens_
Haworth are stated to produce a portion of the _Cape Aloes_ of
commerce.[2544]

Various species of _Agave_, especially _A. americana_ L., are largely
grown, since the first half of the 16th century, in the south of
Europe, and popularly called _Aloë_. All of them are plants of Mexico,
while the true aloes are natives of the old world. Botanically the
genus _Agave_ differs from _Aloë_, in that the former has the ovary
_inferior_, while in the latter it is _superior_. From a chemical point
of view there is also no analogy at all between Aloë and Agave.

=History=—Aloes was known to the Greeks as a production of the island
of Socotra as early as the 4th century B.C., if we might credit a
remarkable legend thus given in the writings of the Arabian geographer
Edrisi.[2545] When Alexander had conquered the king of the Persians
and his fleets had vanquished the islands of India, and he had killed
Pour, king of the Indies, his master Aristotle recommended him to
seek the island that produces _Aloes_. So when he had finished his
conquests in India, he returned by way of the Indian Sea into that of
Oman, conquered the isles therein, and arrived at last at Socotra,
of which he admired the fertility and the climate. And from the
advice which Aristotle gave him he determined to remove the original
inhabitants and to put Greeks in their place, enjoining the latter to
preserve carefully the plant yielding aloes, on account of its utility,
and because that without it certain sovereign remedies could not be
compounded. He thought also that the trade in and use of this noble
drug would be a great advantage for all people. So he took away the
original people of the island of Socotra, and established in their
stead a colony of Ionians, who remained under his protection and that
of his successors, and acquired great riches, until the period when the
religion of the Messiah appeared, which religion they embraced. They
then became Christians, and so their descendants have remained up to
the present time (_circa_ A.D. 1154).

This curious account, which Yule[2546] says is doubtless a fable,
but invented to account for facts, is alluded to by the Mahomedan
travellers of the 9th century[2547] and in the 10th by Masudi,[2548]
who says that in his time aloes was produced only in the island of
Socotra, where its manufacture had been _improved_ by Greeks sent
thither by Alexander the Great.

Aloes is not mentioned by Theophrastus, but appears to have been well
known to Celsus, Dioscorides, Pliny and the author of the Periplus of
the Erythrean Sea, as well as to the later Greek[2549] and the Arabian
physicians. From the notices of it in the Anglo-Saxon leech-books and a
reference to it as one of the drugs recommended to Alfred the Great by
the Patriarch of Jerusalem, we may infer that its use was not unknown
in Britain as early as the 10th century.[2550]

[2544] In the above revision of the medicinal species of _Aloë_ we
have made free use of the observations on the same subject mentioned
in the _Dictionnaire de Botanique_. We have also had the advantage of
consulting W. Wilson Saunders, Esq., F.R.S., whose long familiarity
with these plants in cultivation impart great weight to his opinion.

[2545] _Géographie d’Edrisi_, i. (1836) 47.

[2546] _Marco Polo_, ii. 343.

[2547] _Anciennes Relations des Indes et de la Chine de deux Voyageurs
Mahométans, qui y allèrent dans le neuvième siècle_, traduites de
l’Arabe, Paris, 1718. 113.

[2548] Tome iii. 36.—See Appendix.

[2549] Alexander Trallianus, in Puschmann’s edition (quoted in the
Appendix), i. 578, speaks of Αλόης ὴπατίτιὸυς—_Aloë hepatica_.

[2550] See p. 439. note 1.

At this period and for long afterwards the drug was imported into
Europe by way of the Red Sea and Alexandria. After the discovery of
a route to India by the Cape of Good Hope the old line of commerce
probably began to change.

Pires, an apothecary at Cochin, in a letter on Eastern drugs[2551]
addressed to Manuel, king of Portugal, in 1516, reports that aloes
grows in the island of Çacotora, Aden, Cambaya, Valencia of Arragon,
and in other parts,—the most esteemed being that of Çacotora, and next
is that of Spain; while the drug of Aden and Cambaya is so bad as to be
worthless.

In the early part of the 17th century there was a direct trade in aloes
between England and Socotra; and in the records of the East India
Company there are many notices of the drug being bought of the “King of
Socotra.” Frequently the king’s whole stock of aloes is mentioned as
having been purchased.[2552]

Wellstead, who travelled in Socotra in 1833,[2553] says that in old
times the aloë was far more largely grown there than at present, and
that the walls which enclosed the plantations may still be seen. He
adds that the produce was a monopoly of the Sultan of the island. At
the present day the few productions of Socotra that are exported are
carried by the Arab coasting vessels, coming annually from the Persian
Gulf to Zanzibar, at which place they are transshipped for Indian and
other ports. Dr. Kirk, who has resided at Zanzibar from 1866 to 1873,
informs us that aloes from Socotra arrives in a very soft state packed
in goatskins. From these it is transferred to wooden boxes, in which
it concretes, and is shipped to Europe and America. To avoid loss the
skins have to be washed; and the aloetic liquor evaporated.

Ligon,[2554] who visited the island of Barbados in 1647-50, that is
about twenty years after the arrival of the first settlers, speaks of
the aloë as if it were indigenous, mentioning also the useful plants
which had been introduced. At that period the settlers knew how to
prepare the juice for medicinal use, but had not begun to export it.
Barbados aloes was in the drug warehouses of London in 1693.[2555]

The manufacture of aloes in the Cape Colony of South Africa was
observed by Thunberg in 1773 on the farm of a boer named Peter de Wett,
who was the first to prepare the drug in that country.[2556] Cape Aloes
is enumerated in the stock of a London druggist in 1780, its cost being
set down as £10 per cwt. (1_s._ 9½_d._ per lb.).

A new and distinct sort of aloes, manufactured in the colony of Natal,
appeared in English commerce in 1870. It will be described further on.

_Lignum Aloes_—It is important to bear in mind that the word _Aloes_
or _Lign Aloës_, in Latin _Lignum Aloës_, is used in the Bible and in
many ancient writings to designate a substance totally distinct from
the modern _Aloes_, namely the resinous wood of _Aquilaria Agallocha_
Roxburgh, a large tree[2557] of the order Thymeleaceæ, growing in the
Malayan Peninsula. Its wood constituted a drug[2558] which was, down
to the beginning of the present century, generally valued for use as
incense, but now esteemed only in the East.

[2551] See Appendix.

[2552] _Calendar of State Papers_, Colonial Series, East Indies, China
and Japan, 1513-1616, Lond. 1862.

[2553] _Journ. of the Roy. Geograph. Soc._ v. (1835) 129-229.

[2554] _History of Barbadoes_, Lond. 1673. 98.

[2555] Dale’s _Pharmacologia_ (1693) 361.

[2556] Thunberg, _Travels in Asia, Europe and Africa_, ii. 49. 50.

[2557] Fig. in Royle, _Illustr. of the Himalayan Bot. etc._ (1839) tab.
36. See also _Dictionnaire de Botanique_.

[2558] Hanbury, _Science Papers_, 1876. 263; also Flückiger, _Die
Frankfurter Liste_, Halle, 1873. 37. (_Archiv der Pharm._ cci.
511).—For full historical information see Heyd, _Levantehandel_, ii.
(1879), 559.

=Structure of the Leaf=—The stout fleshy leaves of an aloë have a
strong cuticle and thick-walled epidermis. Their interior substance
is formed of very loose, large-celled, colourless pulp, traversed
by vascular bundles, which, on transverse section, are seen to be
accompanied by a group of large thin-walled cells[2559] containing the
bitter juice which constitutes the drug under notice. These cells, on a
longitudinal section, are seen to be considerably elongated, adjoining
a single row of smaller, prismatic, truncated cells,[2560] by which
the former are separated from the cortical layer. The prismatic cells
contain a yellow juice, apparently different from that which yields
aloes. The cortical tissue is filled with granules of chlorophyll,
and exhibits between the cells groups of needles of calcium oxalate.
Similar crystals are also found sparingly in the pulp.

The transparent pulp-tissue[2561] is rich in mucilage, which after
dilution with water is precipitated by neutral acetate of lead, but is
not coagulated by boiling.

The amount of bitter principles in the leaf probably varies with the
age of the latter and with the season of the year. Haaxman mentions
that, in Curaçao, the maximum is found when the leaves are changing
from green to brown.

=Cultivation and Manufacture=—In Barbados,[2562] where _Aloë vulgaris_
is systematically cultivated for the production of the drug, the
plants are set 6 inches apart, in rows which are 1 to 1½ foot asunder,
the ground having been carefully prepared and manured. They are kept
free from grass and weeds, but yams or pulse are frequently grown
between them. The plants are always dwarf, never in the least degree
arborescent; almost all of those above a year old bear flowers, which
being bright yellow, have a beautiful effect. The leaves are 1-2 feet
long; they are cut annually, but this does not destroy the plant,
which, under good cultivation, lasts for several years.

[2559] The cells lettered _e_ in Berg’s figure C, plate iv. _f._ of his
“_Offizinelle Gewächse_.”

[2560] The cells _d_, in Berg’s figure.

[2561] This central pulpy tissue is _quite tasteless_, and is actually
used as food in times of scarcity in some parts of India.—Stewart,
_Punjab Plants_, 1869. 232.

[2562] For the particulars we here give respecting Barbados aloes,
we have cordially to thank Sir R. Bowcher Clarke, Chief Justice of
Barbados, and also Major-General Munro, stationed (1874) at Barbados in
command of troops.

The cutting takes place in March and April, and is performed in the
heat of the day. The leaves are cut off close to the plant, and placed
_very quickly_, the cut end downwards, in a V-shaped wooden trough,
about 4 feet long and 12 to 18 inches deep. This is set on a sharp
incline, so that the juice which trickles from the leaves very rapidly
flows down its sides, and finally escapes by a hole at its lower end
into a vessel placed beneath. No pressure of any sort is applied to
the leaves. It takes about a quarter of an hour to cut leaves enough
to fill a trough. The troughs are so distributed as to be easily
accessible to the cutters. Their number is generally five; and by the
time the fifth is filled, the cutters return to the first and throw
out the leaves, which they regard as exhausted. The leaves are neither
infused nor boiled, nor is any use afterwards made of them except for
manure.

When the vessels receiving the juice become filled, the latter is
removed to a cask and reserved for evaporation. This may be done at
once, or it may be delayed for weeks or even months, the juice, it
is said, not fermenting or spoiling. The evaporation is generally
conducted in a copper vessel; at the bottom of this is a large ladle,
into which the impurities sink, and are from time to time removed
as the boiling goes on. As soon as the inspissation has reached the
proper point, which is determined solely by the experienced eye of the
workman, the thickened juice is poured into large gourds or into boxes,
and allowed to harden.

The drug is not always readily saleable in the island, but is usually
bought up by speculators who keep it till there is a demand for it in
England. The cultivators are small proprietors, but little capable as
to mind or means of making experiments to improve the manufacture of
the drug. It is said, however, that occasionally a little aloes of very
superior kind is made for some special purpose by exposing the juice
in a shallow vessel to solar heat till completely dry. But such a drug
is stated to cost too much time and trouble to be profitable.[2563]
The manufacture of aloes in the Dutch West Indian island of Curaçao is
conducted in the same manner.[2564]

The manufacture of aloes in the Cape Colony has been thus described to
us in a letter[2565] from Mr. Peter MacOwan of Gill College, Somerset
East:—The operator scratches a shallow dish-shaped hollow in the dry
ground, spreads therein a goatskin, and then proceeds to arrange around
the margin a radial series of aloë leaves, the cut ends projecting
inwards. Upon this, a second series is piled, and then a third—care
being taken that the ends of each series overhang sufficiently, to drop
clear into the central hollow. When these preparations have been made,
the operator either “loafs about” after wild honey, or, more likely,
lies down to sleep. The skin being nearly filled, four skewers run in
and out at the edge square-fashion, give the means of lifting this
primitive saucer from the ground, and emptying its contents into a
cast-iron pot. The liquid is then boiled, an operation conducted with
the utmost carelessness. Fresh juice is added to that which has nearly
acquired the finished consistence; the fire is slackened or urged just
as it happens, and the boiling is often interrupted for many hours,
if neglect be more convenient than attention. In fact, the process is
thoroughly barbarous, conducted without industry or reflection; it is
mostly carried on by Bastaards and Hottentots, but not by Kaffirs.
“The only aloë I have seen used,” says Mr. MacOwan, “is the very large
one with di-or tri-chotomous inflorescence,—_A. ferox_, I believe.”
Backhouse[2566] also names “_Aloë ferox?_” as the species he saw used
near Port Elizabeth in 1838.

[2563] Some extremely fine Barbados aloes in the London market in 1842
was said to have been manufactured in a vacuum-pan.

[2564] Oudemans, _Handleiding tot de Pharmacognosie_, 1865. 316.

[2565] Under date May 7, 1871, addressed to myself.—D. H.

[2566] _Visit to Mauritius and South Africa_, 1844. 157, also 121.

From another correspondent, we learn that the making of aloes in the
Cape Colony is not carried on by preference, but is resorted to when
more profitable work is scarce. The drug is sold by the farmers to
the merchants of the towns on the coast, some of whom have exerted
themselves to obtain a better commodity, and have even imported living
aloe-plants from Barbados.

Nothing is known of the manufacture of the so-called _Socotrine_ or
_Zanzibar Aloes_, or even with certainty in what precise localities it
is carried on.

=General Description=—The differences in the several kinds of
commercial aloes are due to various causes, such as the species of
_Aloë_ employed and the method of extracting the juice. The drug varies
exceedingly: some is perfectly transparent and amorphous, with a glassy
conchoidal fracture; some is opaque and dark with a dull waxy fracture,
or opaque and pallid; or it may be of a light orange-brown and highly
crystalline. It varies in consistence in every degree, from dry and
brittle to pasty, and even entirely fluid and syrup-like.

These diverse conditions are partially explained by an examination
of the very fluid aloes that has been imported of recent years from
Bombay. If some of this aloes is allowed to repose, it gradually
separates into two portions,—the upper a transparent, black liquid,—the
lower, an orange-brown crystalline sediment. If the whole be allowed to
evaporate spontaneously, we get aloes of two sorts in the same mass;
the one from the upper portion being dark, transparent and amorphous,
the other rather opaque and highly crystalline. Should the two layers
become mixed, an intermediate form of the drug results.

The _Hepatic Aloes_ of the old writers[2567] was doubtless this rather
opaque form of Socotrine Aloes; but the term has come to be used
somewhat vaguely for any sort of liver-coloured aloes, and appears to
us unworthy to be retained. Much of the opaque, so-called _Hepatic
Aloes_ does not however owe its opacity to crystals, but to a feculent
matter the nature of which is doubtful.

The odour of aloes is a character which is much depended on by dealers
for distinguishing the different varieties, but it can only be
appreciated by experience, and certainly cannot be described.[2568]

[2567] As Macer Floridus in the 10th century, who writes:—

“Sunt Aloës species geminæ, quæ subrubet estque Intus sicut hepar cum
frangitur, hæc _epatite_ Dicitur et magnas habet in medicamine vires,
Utilior piceo quæ fructa colore videtur.”


[2568] Thus the pale, liver-coloured aloes of Natal is invariably
associated with the transparent Cape Aloes, simply from the fact that
the two drugs have a similar smell. Again, the aloes of Curaçao is at
once recognized by its odour, which an experienced druggist pronounces
to be quite different from that of the aloes produced in Barbados.

=Varieties=—The principal varieties of aloes found in English commerce
are the following:—

1. _Socotrine Aloes_—also called _Bombay_, _East Indian_, or _Zanzibar
Aloes_, and when opaque and liver-coloured, Hepatic Aloes. It is
imported in kegs and tin-lined boxes from Bombay, whither it has
been carried by the Arab traders from the African coast, the Red Sea
ports, or by way of Zanzibar, from Socotra. When of fine quality, it
is of a dark reddish-brown, of a peculiar, rather agreeable odour,
comparable to myrrh or saffron. In thin fragments, it is seen to be
of an orange-brown; its powder is of a tawny reddish-brown. When
moistened with spirit of wine, and examined in a thin stratum under
the microscope, good Socotrine Aloes is seen to contain an abundance
of crystals. As imported, it is usually soft, at least in the interior
of the mass, but it speedily dries and hardens by keeping.[2569] It is
occasionally imported in a completely fluid state (_Liquid Socotrine
Aloes_, _Aloë Juice_), and is not unfrequently somewhat sour and
deteriorated.

Some fine aloes from Zanzibar, of which a very small quantity was
offered for sale in 1867, was contained in a skin, and composed of two
layers, the one amorphous, the other a granular translucent substance
of light colour, which when softened and examined with a lens, was seen
to be a mass of crystals. A very bad, dark, fœtid sort of aloes is
brought to Aden from the interior. It seems to be the _Moka Aloes_ of
some writers.

The quantity of aloes imported into Bombay in the year 1871-72 was 892
cwt., of which 736 cwt. are reported as shipped from the Red Sea ports
and Aden.[2570]

[2569] The average loss as estimated in the drying of 560 lb., upon
several occasions, was about 14 per cent.—Laboratory statistics,
communicated by Messrs. Allen and Hanburys, London.

[2570] _Statement of the Trade and Navigation of the Presidency of
Bombay for 1871-72_, pt. ii. 19.

2. _Barbados Aloes_—Characteristic samples show it as a hard dry
substance of a deep chocolate-brown, with a clean, dull, waxy fracture.
In small fragments it is seen to be translucent and of an orange-brown
hue. When breathed upon, it exhales an odour analogous to, but easily
distinguishable from, that of Socotrine aloes. It is imported in
boxes and gourds. The gourds, into which the aloes has been poured in
a melted state through a square hole, over which a bit of calico is
afterwards nailed, contain from 10 to 40 lb. or more. Of late years,
Barbados aloes having a smooth and glassy fracture has been imported;
it is known to the London drug-brokers as “_Capey Barbados_.” By
keeping, it passes into the usual variety having a dull fracture.

The export of aloes from Barbados in 1871, as shown by the _Blue Book_
for that colony, was 1046 cwt., of which 954 cwt. were shipped to the
United Kingdom.

3. _Curaçao Aloes_—manufactured in the Dutch West Indian islands of
Curaçao, Bonaire, and Aruba, is imported into this country by way
of Holland, packed in boxes of 15 to 28 lb. each. In appearance it
resembles Barbados aloes, but has a distinctive odour.

4. _Cape Aloes_—The special features of this sort of aloes are its
brilliant conchoidal fracture and peculiar odour. Small splinters seen
by transmitted light are highly transparent and of an amber colour;
the powder is of a pale tawny yellow. When the drug is moistened and
examined under the microscope, no crystals can be detected, even after
the lapse of some days. Cape aloes has the odour of other kinds of
aloes, with a certain sourish smell which easily distinguishes it.
Several qualities are recognized, chiefly by the greater or lesser
brilliancy of fracture, and by the tint of the powder.

From the _Blue Book_ for the Colony of the Cape of Good Hope, published
at Cape Town in 1873, it appears that the export of aloes in 1872 was
484,532 lb. (4326 cwt.); and that the average market value during the
year was 3¾_d._, the lowest price, 1½_d._, being at Riversdale and
Mossel Bay, and the highest, 11_d._, at Swellendam. The drug is shipped
from Cape Town, Mossel Bay and Algoa Bay.

5. _Natal Aloes_—Aloes is also imported from Natal, and since 1870 in
considerable quantity. Most of it is of an hepatic kind and completely
unlike the ordinary Cape aloes, inasmuch as it is of a greyish-brown
and very opaque. Moreover it contains a crystalline principle which has
been found in no other sort of aloes.

The drug is manufactured in the upper districts of Natal, between
Pietermaritzburg and the Quathlamba mountains, especially in the Umvoti
and Mooi River Counties, at an elevation of 2000 to 4000 feet above the
sea. The plant used is a large aloë which has not yet been botanically
identified. The people who make the drug are British and Dutch
settlers, employing Kaffir labourers. The process is not very different
from that followed in making Cape aloes, but is conducted with more
intelligence. The leaves are cut obliquely into slices, and allowed to
exude their juice in the hot sunshine. The juice is then boiled down in
iron pots, some care being taken to prevent burning, by stirring the
liquid as it becomes thick. The drug while still hot, is poured into
wooden cases, in which it is shipped to Europe.[2571] The exports from
the colony have been as follows:—[2572]

    1868        1869        1870        1871        1872
    none       38 cwt.     646 cwt.    372 cwt.    501 cwt.

=Chemical Composition=—All kinds of aloes have an odour of the same
character and a bitter disagreeable taste. The odour which is often not
unpleasant, especially in Socotrine aloes, is due to a _volatile oil_,
which the drug contains only in minute proportion. T. and H. Smith of
Edinburgh, who contributed a specimen of it to the Vienna Exhibition
of 1873, inform us that they obtained it by subjecting to distillation
with water 400 lb. of aloes, which quantity they estimate to have
yielded about an ounce. The oil is stated in a letter we have received
from them, to be a mobile pale yellow liquid, of sp. gr. 0·863, with a
boiling point of 266-271° C.

Pure aloes dissolves easily in spirit of wine with the exception of a
few flocculi; it is insoluble in chloroform and bisulphide of carbon,
as well as in the so-called petroleum ether, the most volatile portion
of American petroleum. The sp. gr. of fine transparent fragments of
aloes, dried at 100° C., and weighed in the last named fluid at 16° C.,
was found by one of us (F.) to be 1·364; showing that aloes is much
more ponderous than most of the resins, which seldom have a higher
sp. gr. than 1·00 to 1·10. In water aloes dissolves completely only
when heated. On cooling, the aqueous solution, whether concentrated
or dilute, becomes turbid by the separation of resinous drops, which
unite into a brown mass,—the so-called _Resin of Aloes_.[2573] The
clear solution, after separation of this substance, has a slightly
acid reaction; it is coloured dark brown by alkalis, black by ferric
chloride, and is precipitated yellowish-grey by neutral lead acetate.
Cold water dissolves about half its weight of aloes, forming an acid
liquid which exhibits similar reactions. The solution of aloes in
potash or ammonia is precipitated by acids, but not by water.

[2571] We have to thank J. W. Akerman, Esq., of Pietermaritzburg, for
the foregoing information as to the manufacture of this drug.

[2572] _Blue Books for the Colony of Natal for 1868, 1869, 1870, 1871,
1872._

[2573] The average yield of aqueous extract made by the pharmacopœia
process from commercial Socotrine aloes containing about 14 per cent.
of water, was found from the record of five experiments, in which 179
lb. were used, to be 62·7 per cent. Barbados aloes, which is always
much drier, afforded on an average 80 per cent.

The most interesting constituents of aloes are the substances known
as _Aloïn_. This name was originally applied to an aloïn which, as
it appears to be found exclusively in Barbados aloes, is now termed
_Barbaloïn_, in order to distinguish it from allied substances
occurring in Natal and Socotrine aloes.

Barbaloïn was discovered by T. and H. Smith of Edinburgh in 1851,[2574]
and was described (1851) by Stenhouse. From good qualities of the drug
it can be obtained, according to Tilden,[2575] as a crystalline mass,
to the extent of 20 to 25 per cent., but in others it appears to occur
partly amorphous or in a chemically altered state. Barbaloïn is a
neutral substance, crystallizing in tufts of small yellow prisms. These
crystals represent _hydrated_ aloïn, and part with one molecule of
water (=2·69 per cent.) by desiccation _in vacuo_, or by the prolonged
heat of a water-bath. Barbaloïn, C₃₄H₃₆O₁₄ + H₂O, dissolves sparingly
in water or alcohol but very freely if either liquid be even slightly
warmed; it is insoluble in ether.

The solutions alter quickly if made a little alkaline, but if neutral
or slightly acid, are by no means very prone to decomposition. By
oxidation with nitric acid, barbaloïn yields, as Tilden (1872) has
shown, about a third of its weight of chrysammic acid, besides aloëtic,
oxalic, and picric acids. It easily combines with bromine to form
yellow needles of _Bromaloïn_, C₃₄H₃₀Br₆O₁₄; _Chloraloïn_, C₃₄H₃₀Cl₆O₁₄
+ 6H₂O, crystallizing in prisms, has likewise been obtained.

In examining Natal aloes in 1871, we observed it to contain a distinct
crystalline body, much less soluble than the ordinary aloïn of Barbados
aloes. We have accordingly named it _Nataloïn_.

Nataloïn exists naturally in Natal aloes, from which it can be easily
prepared in the crude state, if the drug is triturated with an equal
weight of alcohol at a temperature not exceeding 48° C. This will
dissolve the amorphous portion, from which the crystals should be
separated by a filter, and washed with a small quantity of cold spirit.
From 16 to 25 per cent. of crude nataloïn in pale yellow crystals may
be thus extracted. When purified by crystallization from methylic
alcohol or spirit of wine, it forms thin, brittle, rectangular scales,
often with one or more of their angles truncated. The formula assigned
to nataloïn by Tilden, which is supported by the composition of the
acetyl derivative he has succeeded in obtaining, is C₂₅H₂₈O₁₁.

At 15·5° C., 60 parts of alcohol, 35 of methylic alcohol,[2576] 50 of
acetic ether, 1236 of ether, and 230 of absolute alcohol, dissolve
respectively one part of nataloïn. It is scarcely more soluble in
warm than in cold spirit of wine, so that to obtain crystals it is
best to allow the solution to evaporate spontaneously. Water hot or
cold dissolves it very sparingly. Nataloïn gives off no water when
exposed over oil of vitriol, or to a temperature of 100° C. By the
action of nitric acid, it affords both oxalic and picric acids, but no
chrysammic acid. It appears not to combine with chlorine or bromine,
and we have failed in obtaining from it any such body as bromaloïn.

[2574] Most beautiful specimens have been presented to each of us by
these gentlemen.

[2575] _Pharm. Journ._ April 28, 1872. 845.—See also Nov. 5, 1870. 375.

[2576] The best crystals can be got by this solvent.

Liquid Socotrine aloes, imported into London about 1852, was noticed
by Pereira to abound in minute crystals, which he termed the _Aloïn
of Socotrine Aloes_, and regarded as probably identical with that of
Barbados aloes. Some fine dry aloes from Zanzibar of very pale hue, in
our possession, is in reality a perfectly crystalline mass.

Histed was the first to assert that the crystalline matter of Socotrine
or Zanzibar aloes is a peculiar substance, according neither with
barbaloïn nor with nataloïn. This observation was fully corroborated
by our own experiments,[2577] made chiefly on the Zanzibar aloes just
described, and we shall call the substance thus discovered _Socaloïn_.
In this drug, the crystals are prisms of comparatively large size, such
as we have never observed in Natal aloes. They cannot be so easily
isolated as nataloïn, since they are nearly as soluble as the amorphous
matter surrounding them. Histed recommends treating the powdered crude
drug with a little alcohol, sp. gr. 0·960, and strongly pressing the
pasty mass between several thicknesses of calico; then dissolving
the yellow crystalline cake in warm weak alcohol, and collecting the
crystals which are formed by cooling and repose.

Socaloïn forms tufted acicular prisms, which by solution in methylic
alcohol may be got 2 to 3 millimetres long. It is much more soluble
than nataloïn. At ordinary temperatures, 30 parts of alcohol, 9 of
acetic ether, 380 of ether, 90 of water are capable of dissolving
respectively one part of socaloïn; while in methylic alcohol, it is
most abundantly soluble. Socaloïn is a hydrate, losing when dried over
oil of vitriol 11 to 12 per cent. of water, but slowly regaining it if
afterwards exposed to the air. Its elementary composition according to
the analysis made by one of us (F.) is C₃₄H₃₈O₁₅ + 5 H₂O. We have not
succeeded in obtaining any well-defined bromine compound of socaloïn.

The three aloïns, _Barbaloïn_, _Nataloïn_, and _Socaloïn_, are easily
distinguished by the following beautiful reaction first noticed by
Histed:—a drop of nitric acid on a porcelain slab gives with a few
particles of barbaloïn or nataloïn, a vivid crimson,[2578] but produces
little effect with socaloïn. To distinguish barbaloïn from nataloïn,
test each by adding a minute quantity to a drop or two of oil of
vitriol, then allowing the _vapour_ from a rod touched with nitric acid
to pass over the surface. Barbaloïn (and socaloïn) will undergo no
change, but nataloïn will assume a fine blue.[2579]

[2577] Flückiger, _Crystalline Principles in Aloes_,—_Pharm. Journ._
September 2, 1871. 195.

[2578] Rapidly fading in the case of barbaloïn, but permanent with
nataloïn unless heat be applied.

[2579] These reactions may be sometimes got even with the crude drugs.

The researches of E. von Sommaruga and Egger in Vienna (1874) have been
directed in particular to the aloïn of Socotrine aloes. The melting
point of this aloïn was found to be between 118° and 120° C., that
of barbaloïn being much higher. The authors conclude that the three
form an homologous series, that their composition may probably be
represented thus:—

    Barbaloïn     C₁₇H₂₀O₇
    Nataloïn      C₁₆H₁₈O₇
    Socaloïn      C₁₅H₁₆O₇

They derive in all probability from anthracene, C₁₄H₁₀.

The portion of aloes insoluble in cold water was formerly distinguished
as _Resin of Aloes_, from the soluble portion which was called _Bitter
of aloes_ or _Aloëtin_. From the labours of Kossmann (1863), these
portions appear to have nearly the same composition. The soluble
portions treated with dilute sulphuric acid, is said to yield
_Aloëresic_ and _Aloëretic Acids_, both crystallizable, besides the
indifferent substance _Aloëretin_. These observations have not to our
knowledge been confirmed.

It has been shown by Tilden and Rammell[2580] that the _Resin of Aloes_
may by prolonged treatment with boiling water be separated into two
bodies, which they distinguish as _Soluble Resin A._ and _Insoluble
Resin B._ With the first it is possible to form a brominated compound,
which though non-crystalline is apparently of definite composition. In
the view of these chemists the _Resin A._ is a kind of anhydride of
barbaloïn—Barbaloïn, 2(C₃₄H₃₆O₁₄) less H₂O = Aloe Resin A., C₆₈H₇₀O₂₇.
The resin boiled with nitric acid yields a large amount of chrysammic
acid, together with picric and oxalic acids, and carbonic anhydride.
_Insoluble Resin B._ was found to have nearly the same composition as
_Resin A._

[2580] _Pharm. Journ._ Sept. 21, 1872. 235.

Aloes treated with various reagents affords a number of remarkable
products. Thus, according to Rochleder and Czumpelick (1861) it yields,
when boiled with soda-lye, colourless crystals an inch long, which
appear to consist of a salt of _Paracumaric Acid_, together with small
quantities of fragrant essential oils and volatile fatty acids.

When boiled with dilute sulphuric acid, aloes yields paracumaric acid,
from which by fusion with caustic potash, as also directly from aloes,
Hlasiwetz (1865) obtained _Para-oxybenzoic Acid_ (p. 408). Weselsky
(1872-73) has shown that accompanying the last two products, there is a
peculiar, crystallizable acid, C₉H₁₀O₃, which he has named _Alorcinic
Acid_.

By distillation with quicklime, E. Robiquet (1846) obtained _Aloïsol_,
a yellowish oil, which Rembold (1866) proved to be a mixture of
dimethylated phenol (_Xylenol_)

         {(CH₃)₂
    C₇H₃ {, with acetone and hydrocarbons.
         {OH

Nitric acid forms with Barbadoes aloes, but still better, as Tilden
has shown, with barbaloïn, _Aloëtic Acid_, C₁₄H₄(NO₂)₄O₂, _Chrysammic
Acid_, C₁₄H₄(NO₂)₄O₄, and finally _Picric Acid_, together with _Oxalic
Acid_. The first two of these acids are distinguished by the splendid
tints of their salts, which might be utilized in dyeing.

Chlorine, passed into an aqueous solution of aloes, forms a variety of
substitution-products, and finally _Chloranil_, C₆Cl₄O₂.

When somewhat strongly heated, aloes swells up considerably, and after
ignition leaves a light, slow-burning charcoal, almost free from
inorganic constituents. Ordinary Cape aloes, for example, dried at 100°
C., leaves only 1 per cent. of ash.

=Commerce=—There were imported into the United Kingdom in the year
1870, 6264 cwt. of aloes. Of this quantity, South Africa shipped 4811
cwt.; and Barbados 970 cwt. The remainder was probably furnished by
Eastern Africa.

The commercial value of the varieties of aloes is very different.
In 1874, _Barbados Aloes_ was quoted in price-currents at £3 5_s._
to £9 10_s._ per cwt.; _Socotrine_ at £5 to £13; while _Cape Aloes_
was offered at £1 10_s._ to £2. In England, the first two alone
are allowed for pharmaceutical preparations. Even the _Veterinary
Pharmacopœia_[2581] names only _Aloë Barbadensis_. Cape Aloes is
esteemed on the Continent, and chiefly consumed there.

=Use=—Aloes is a valuable purgative in very common use, it is generally
given combined with other drugs.

=Adulteration=—The physical characters of aloes, such as colour of the
powder, odour, consistence and freedom from obvious impurity, coupled
with its solubility in weak alcohol, usually suffice for determining
its goodness.


BULBUS SCILLÆ.

_Radix Scillæ_; _Squill_; F. _Bulbe ou squames de Scille_, _Ognon
marin_; G. _Meerzwiebel_.

=Botanical Origin=—_Urginea maritima_ Baker[2582] (_Scilla maritima_
L., _Urginea Scilla_ Steinheil). It is found generally in the regions
bordering the Mediterranean, as in Southern France, Italy, Dalmatia,
Greece, Asia Minor, Syria, North Africa and the Mediterranean islands.
In Sicily, where it grows most abundantly, Urginea ascends to
elevations of 3000 feet. It is also very common throughout the South of
Spain, where it is by no means confined to the coast; it occurs also in
Portugal. In the Riviera of Genoa the peasants like to see it growing
under the fig trees.

Two varieties of squill, termed respectively _white_ and _red_,
are distinguished by druggists. In the first, the bulb-scales are
colourless; in the second they are of a roseate hue. No other
difference in the plants can be pointed out, nor have the two varieties
distinct areas of growth.

=History=—Squill is one of the most ancient of medicines. Epimenides,
a Greek who lived in the 30th Olympiad, is said to have made much use
of it, from which circumstance it came to be called _Epimenidea_[2583].
It is also mentioned by Theophrastus, and was probably well known
to all the ancient Greek physicians. Pliny was not only acquainted
with it, but had noticed its two varieties. Dioscorides describes the
method of making vinegar of squills; and a similar preparation, as well
as compounds of squill with honey, were administered by the Arabian
physicians, and still remain in use. The medical school of Salerno
preferred the red variety of the drug, which on the whole is not
frequently met with in mediæval literature.

[2581] By R. V. Tuson, London, 1869.

[2582] _Journ. of Linn. Soc._, Bot., xiii. (1872) 221.—The genus
_Urginea_ has flat, discoid seeds, while in _Scilla_ proper they are
triquetrous. The name _Urginea_ was given in allusion to the Algerian
tribe Ben _Urgin_, near Bona, where Steinheil (1834) examined this
plant.

[2583] Haller, _Bibliotheca botanica_, i. 12.

=Description=—The bulb of squill is pear-shaped, and of the size of
a man’s fist or larger, often weighing more than four pounds. It
has the usual structure of a tunicated bulb; its outer scales are
reddish-brown, dry, scarious, and marked with parallel veins. The inner
are fleshy and juicy, colourless or of a pale rose tint, thick towards
the middle, very thin and delicate at the edges, smooth and shining on
the surface. The fresh bulb has a mucilaginous, bitter, acrid taste,
but not much odour.

For medicinal use, squill is mostly imported ready dried. The bulbs are
collected in the month of August, at which period they are leafless,
freed from their dry outer scales, cut transversely into thin slices,
and dried in the sun. Thus prepared, the drug appears in the form of
narrow, flattish or four-sided curved strips, 1 to 2 inches long, and ⅜
to ⅝ of an inch wide, flexible, translucent, of a pale dull yellowish
colour, or when derived from the red variety, of a decided roseate
hue. When thoroughly dried, they become brittle and pulverizable, but
readily absorb water to the extent of about 11 per cent. Powdered
squill by the absorption of water from the air, readily cakes together
into a hard mass.

=Microscopic Structure=—The officinal portion of the plant being simply
modified leaves, has the histological characters proper to many of
those organs. The tissue is made up of polyhedral cells, covered on
both sides of the scales by an epidermis provided with stomata. It
is traversed by numerous vascular bundles, and also exhibits smaller
bundles of laticiferous vessels. If thin slices of squill be moistened
with dilute alcohol, most of the parenchymatous cells are seen to be
loaded with _mucilage_, which contracts into a jelly on the addition of
alcohol. In the interior of this jelly, crystalline particles are met
with consisting of oxalate of calcium. This salt is largely deposited
in cells, forming either bundles of needle-shaped crystals, or large
solitary square prisms, frequently a millimetre long. In either case
they are enveloped by the mucilaginous matter already mentioned.
Oxalate of calcium as occurring in other plants has been shown in many
instances to originate in the midst of mucilaginous matter. The fact is
remarkably evident in _Scilla_, especially when examined in polarized
light.

On shaking thin slices of the bulb with water, the crystals are
deposited in sufficient quantity to become visible to the naked eye,
though their weight is actually very small. Direct estimation of the
oxalic acid (by titration with chamæleon solution) gave us only 3·07
per cent. of C₂CaO₄,3H₂O from white squill dried at 100° C., which
moreover yielded only 2 to 5 per cent. of ash. It is these extremely
sharp brittle crystals which occasion the itching and redness, and
sometimes even vesication, which result from rubbing a slice of fresh
squill on the skin. These effects, which have long been known, were
attributed to a volatile acrid principle, until their true cause was
recognized by Schroff.[2584]

[2584] We have found that the slimy juice of the leaves of _Agapanthus
umbellatus_ Hérit., which is very rich in spicular crystals, also
occasions when rubbed on the skin both itching and redness, lasting for
several hours.

The mucilage also contains albuminous matters, hence the orange colour
it assumes on addition of iodine. The vascular bundles are accompanied
by some rows of longitudinally extended cells, containing a small
number of starch granules. In the red squill the colouring matter is
contained in many of the parenchymatous cells, others being entirely
devoid of it. It turns blackish-green if a persalt of iron be added.

=Chemical Composition=—The most abundant among the constituents of
squill are mucilaginous and saccharine matters. Mucilage may be
precipitated by means of neutral and basic acetate of lead, yet there
remains in solution another substance of the same class, called
_Sinistrin_. It was discovered in 1879 by Schmiedeberg, who obtained it
by mixing the powder of squill, either red or white, with a solution of
basic acetate of lead in slight excess. The gummy matters thus forming
insoluble lead compounds being removed, the liquid is deprived of the
lead and mixed with slaked lime. An insoluble compound of sinistrin
and calcium separates and yields the former on decomposing the well
washed precipitate with carbonic acid. The small amount of calcium
remaining in the filtrate is to be removed by adding cautiously to the
warm solution the small quantity just required of oxalic acid. Lastly,
sinistrin is thrown down by alcohol. It is a white amorphous powder, on
exposure to air soon forming transparent brittle lumps. The composition
of sinistrin is that of dextrin = C₆H₁₀O₅, both these substances being
very closely allied, yet the aqueous solution of sinistrin deviates the
plane of polarization to the left. The rotatory power appears not to be
much influenced by the concentration or the temperature of the solution
of sinistrin.

An alkaline solution of tartrate of copper is not acted upon by
sinistrin. It is transformed into sugar by boiling it for half an hour
with water containing 1 per cent. of sulphuric acid. The sugar thus
produced is stated by Schmiedeberg to consist of lævulose[2585] and
another sugar, which in all probability, when perfectly pure, must
prove devoid of rotatory power.

The name sinistrin[2586] has also been applied to a mucilaginous matter
extracted from barley (see Hordeum decorticatum); it remains to be
proved that the latter is identical with the sinistrin of squill.

We have obtained a considerable amount of an uncrystallizable levogyre
sugar by exhausting squill with dilute alcohol.[2587] Alcohol added to
an aqueous infusion of squill causes the separation of the mucilage,
together with albuminoid matter. If the alcohol is evaporated and
a solution of tannic acid is added, the latter will combine with
the _bitter principle_ of squill, which has not yet been isolated,
although several chemists have devoted to it their investigations,
and applied to it the names of _Scillitin_ or _Skuleïn_. Schroff, to
whom we are indebted for a valuable monograph on Squill,[2588] infers
from his physiological experiments the presence of a non-volatile
acrid principle (_Skulein?_), together with scillitin, which latter he
supposes to be a glucoside.

Merck of Darmstadt has isolated _Scillipicrin_, soluble in water;
_Scillitoxin_, likewise a bitter principle, insoluble in water, but
readily dissolving in alcohol; and _Scillin_, a crystalline substance,
abundantly soluble in boiling ether. The physiological action of these
substances and of _Scillaïn_ has been examined (1878) by Moeller, and
by Jarmersted (1879); that of scillitoxin and scillaïn was found to be
analogous to that of Digitalis.

[2585] This is the name applied to the lævogyrate uncrystallizable
glucose produced, together with crystallizable dextro-glucose, by
decomposing cane-sugar by means of dilute acids.

[2586] In 1834 first proposed, by Marquart, for inulin.

[2587] In Greece they have even attempted to manufacture alcohol by
fermenting and distilling squill bulbs.—Heldreich, _Nutzpflanzen
Griechenlands_, 1862. 7.

[2588] Reprinted from the _Zeitschrift der Gesellschaft der Aerzte zu
Wien_, No. 42 (1864). Abstracted also in Canstatt’s _Jahresbericht_
1864. 19, and 1865. 238.

=Commerce=—Dried squill, usually packed in casks, is imported into
England from Malta.

=Use=—Commonly employed as a diuretic and expectorant.

=Substitutes=—There are several plants of which the bulbs are used in
the place of the officinal squill, but which, owing to the abundance
and low price of the latter, never appear in the European market.

1. _Urginea altissima_ Baker (_Ornithogalum altissimum_ L.), a South
African species, very closely related to the common squill, and having,
as it would appear, exactly the same properties.[2589]

2. _U. indica_ Kth. (_Scilla indica_ Roxb.), a widely diffused plant,
occurring in Northern India, the Coromandel Coast, Abyssinia, Nubia,
and Senegambia. It is known by the same Arabic and Persian names as _U.
maritima_, and its bulb is used for similar purposes. But according to
Moodeen Sheriff[2590] it is a poor substitute for the latter, having
little or no action when it is old and large.

3. _Scilla indica_ Baker[2591] (non Roxb.), (_Ledebouria hyacinthina_
Roth), native of India and Abyssinia, has a bulb which is often
confused in the Indian bazaars with the preceding, but is easily
distinguishable when entire by being _scaly_ (not tunicated); it is
said to be a better representative of the European squill.[2592]

4. _Drimia ciliaris_ Jacq., a plant of the Cape of Good Hope, of the
order _Liliaceæ_. Its bulb much resembles the officinal squill, but has
a juice so irritating if it comes in contact with the skin, that the
plant is called by the colonists _Jeukbol_, i.e. _Itch-bulb_. It is
used medicinally as an emetic, expectorant, and diuretic.[2593]

5. _Crinum asiaticum_ var. _toxicarium_ Herbert (_C. toxicarium_
Roxb.), a large plant, with handsome white flowers and noble foliage,
cultivated in Indian gardens, and also found wild in low humid spots
in various parts of India and the Moluccas, and on the sea-coast of
Ceylon. The bulb has been admitted to the _Pharmacopœia of India_
(1868), chiefly on the recommendation of O’Shaughnessy, who considers
it a valuable emetic. We have not been able to examine a specimen,
and cannot learn that the drug has been the subject of any chemical
investigation.

[2589] Pappe, _Floræ Medicæ Capensis Prodromus_, ed. 2, 1857. 41.

[2590] _Supplement to the Pharmacopœia of India_, Madras, 1869. 250.

[2591] Saunders, _Refugium Botanicum_, iii. (1870) appendix, p. 12.

[2592] _Suppl. to the Pharm. of India_, 250.

[2593] Pappe, _op. cit._ 42.




MELANTHACEÆ.


RHIZOMA VERATRI ALBI.

_Radix Veratri_, _Radix Hellebori albi_; _White Hellebore_; F. _Racine
d’Ellébore blanc_; G. _Weisse Nieswurzel_, _Germer_.

=Botanical Origin=—_Veratrum album_ L.—This plant occurs in moist
grassy places in the mountain regions of Middle and Southern Europe,
as Auvergne, the Pyrenees, Spain, Switzerland, and Austria. In Norway
it reaches, according to Schübeler (_l. c._ p. 556), the latitude of
71°. It also grows throughout European and Asiatic Russia as far as 61°
N. lat., in Amurland, the island of Saghalin, Northern China, and Japan.

=History=—The confusion that existed among the ancients between
_Melampodium_, _Helleborus_, and _Veratrum_, makes the identification
of the plant under notice extremely unsatisfactory.[2594] It was
perfectly described or figured by Brunfels, Tragus, and other botanists
of the 16th century, and likewise well known to Gerarde (_circa_ A.D.
1600). Under the names of _Elleborus_ (or _Helleborus albus_) and
_Veratrum_, it has had a place in all the London Pharmacopœias. In the
British Pharmacopœia (1867) it has been replaced by the nearly allied
American species, _Veratrum viride_ Aiton.

=Description=—White Hellebore has a cylindrical, fleshy, perennial
rootstock, 2 to 3 inches in length, and ¾ to 1 inch in diameter, beset
with long stout roots. When fresh it has an alliaceous smell. In the
dried state, as it occurs in commerce, it is cylindrical or subconical,
of a dull earthy black, very rough in its lower half with the pits and
scars of old roots; more or less beset above with the remains of recent
roots. The top is crowned with the bases of the leaves, the outer of
which are coarsely fibrous. The plant has generally been cut off close
to the summit of the rhizome, which latter is seldom quite entire,
being often broken at its lower end, or cut transversely to facilitate
drying. Internally it is nearly colourless; a transverse section shows
a broad white ring surrounding a spongy pale buff central portion.

The drug has a sweetish, bitterish acrid taste, leaving on the tongue
a sensation of numbness and tingling. In the state of powder, it
occasions violent sneezing.

=Microscopic Structure=—When cut transversely, the rhizome shows at
a distance of 2-4 mm. from the thin dark outer bark, a fine brown
zigzag line (medullary sheath) surrounding the central part, which
exhibits a pith not well defined. The zone between the outer bark
and the medullary sheath is pure white, with the exception of some
isolated cells containing resin or colouring matter, and those places
where the rootlets pass from the interior. The latter is sprinkled as
it were, with short, thin somewhat lighter bundles of vessels which
run irregularly out in all directions. The parenchyme of the centre
rhizome is filled with starch, and contains numerous needles of calcium
oxalate. The rootlets, which the collectors usually remove, are living
and juicy only in the upper half of the rhizome, the lower part of
which is rather woody and porous.

=Chemical Composition=—In 1819 Pelletier and Caventou detected in the
rhizome of _Veratrum_ a substance which they regarded as identical with
veratrine, the existence of which had just been discovered by Meissner
in cebadilla seeds. But according to the observations of Maisch (1870)
and Dragendorff,[2595] the veratrine of cebadilla cannot be found
either in _Veratrum album_ or _V. viride_.

[2594] Those who wish to study the question, can consult Murray’s
_Apparatus Medicaminum_. vol. v. (1790) 142-146.

[2595] _Beitr. zur gerichtl. Chemie_, St Petersb., 1872. 95.

Simon (1837) found in the root the alkaloid _Jervine_, Tobien (1877)
the _Veratroïdine_, discovered by Bullock (1876) in _Veratrum viride_.
Tobien assigns to jervine the formula C₂₇H₄₇N₂O₈; that of veratroïdine
is not yet settled. The latter is to some extent soluble in water.

Weppen (1872) has isolated from this drug _Veratramarin_, an amorphous,
deliquescent, bitter principle. It occurs in minute quantity only, and
is resolvable into sugar and other products. Veratramarin dissolves
in water or spirit of wine, not in ether or in chloroform. The same
observer has also isolated, to the extent of ½ per mille, _Jervic
Acid_ in hard crystals of considerable size,[2596] of the composition
C₁₄H₁₀O₁₂ + 2 H₂O. The acid requires 100 parts of water for solution at
the ordinary temperature, and a little less of boiling alcohol. It is
decidedly acid, and forms well-defined crystallizable salts, containing
4 atoms of the monovalent metals.

By exhausting the entire rhizome (roots included) with ether and
anhydrous alcohol, we obtained 25·8 per cent. of soft resin, which
deserves further examination. Pectic matter to the amount of 10 per
cent. was pointed out by Wiegand in 1841.

According to Schroff (1860), in the rootlets the active principle
resides in the cortical part, the woody central portion being inert. He
also asserts that the rhizome acts less strongly than the rootlets, and
in a somewhat different manner.

=Commerce=—The drug is imported from Germany in bales. The
price-currents distinguish _Swiss_ and _Austrian_, and generally name
the drug as “_without fibre_.”

=Uses=—Veratrum is an emetic and drastic purgative, rarely used
internally. It is occasionally employed in the form of ointment in
scabies. Its principal consumption is in veterinary medicine.

=Substitutes=—The rhizome of the Austrian _Veratrum nigrum_ L. is said
to be sometimes collected instead of White Hellebore; it is of much
smaller size, and, according to Schroff, less potent. That of the
Mexican _Helonias frigida_ Lindley (_Veratrum frigidum_ Schl.) appears
to exactly resemble that of _Veratrum album_.


RHIZOMA VERATRI VIRIDIS.

_American White Hellebore_,[2597] _Indian Poke_.

=Botanical Origin=—_Veratrum viride_ Aiton, a plant in every respect
closely resembling _V. album_, of which it is one of the numerous
forms. In fact, the green-coloured variety of the latter (_V.
Lobelianum_ Bernh.), a plant not uncommon in the mountain meadows
of the Alps, comes so near to the American _V. viride_ that we are
unable to point out any important character by which the two can be
separated.[2598] The American _Veratrum_ is common in swamps and low
grounds from Canada to Georgia.

[2596] For good specimens of which I am indebted to Dr. Weppen.—F. A. F.

[2597] The name _Green Hellebore_ is sometimes applied to this drug,
but it properly belongs to _Helleborus viridis_ L., which is medicinal
in some parts of Europe.

[2598] Sims in contrasting _Veratrum viride_ with _V. album_ observes
that the flowers of the former are “more inclined to a yellow green,”
the petals broader and more erect, with the margins, especially
about the claw, thickened and covered with a white mealiness. _Bot.
Mag._ xxvii. (1808) tab. 1096.—Regel has described four varieties of
_Veratrum album_ L., as occurring in the region of the Lower Ussuri and
Amurland, one of which, var. γ., he has identified with the American
_V. viride_.—_Tentamen Floræ Ussuriensis_, St. Petersb. 1761. 153.

=History=—The aborigines of North America were acquainted with
the active properties of this plant before their intercourse with
Europeans, using it according to Josselyn,[2599] who visited the
country in 1638-1671, as a vomit in a sort of ordeal. He calls it
_White Hellebore_, and states that it is employed by the colonists as a
purgative, antiscorbutic and insecticide.

Kalm (1749) states[2600] that the early settlers used a decoction of
the roots to render their seed-maize poisonous to birds, which were
made “delirious” by eating the grain, but not killed; and this custom
was still practised in New England in 1835 (Osgood).

The effects of the drug have been repeatedly tried in the United States
during the present century; and about 1862, in consequence of the
strong recommendations of Drs. Osgood, Norwood, Cutter, and others, it
began to be prescribed in this country.

=Description=—In form, internal structure, odour and taste, the rhizome
and roots accord with those of _Veratrum album_; yet owing to the
method of drying and preparing for the market, the American veratrum
is immediately distinguishable from the White Hellebore of European
commerce. We have met with it in three forms:—

1. The rhizome with roots attached, usually cut lengthwise into
quarters, sometimes transversely also, densely beset with the pale
brown roots, which towards their extremities are clothed with slender
fibrous rootlets.

2. Rhizome and roots compressed into solid rectangular cakes, an inch
in thickness.

3. The rhizome _per se_, sliced transversely and dried. It forms
whitish, buff, or brownish discs, ½ to 1 inch or more in diameter, much
shrunken and curled by drying. This is the form in which the drug is
required by the United States Pharmacopœia.

=Chemical Composition=—No chemical difference between _Veratrum viride_
and _V. album_ has yet been ascertained. The presence of veratrine,
suspected by previous chemists, was asserted by Worthington[2601] in
1839, J. G. Richardson of Philadelphia in 1857, and S. R. Percy in
1864. Scattergood[2602] obtained from the American drug 0·4 per cent.
of this alkaloid, which however, in consequence of some observations
of Dragendorff (p. 694), we must hold to be not identical with that
of cebadilla. As stated in a previous page jervine and veratroïdine
are present as in the White Hellebore of Europe. Robbins[2603] further
isolated _Veratridine_, a crystallized alkaloid possessed of a similar
physiological action to that of veratrine, though in a less degree.
Veratridine is readily soluble in ether; its solution in concentrated
sulphuric acid is at first yellow, changing quickly to a pink-red, and,
after several hours’ standing, assumes a clear indigo-blue colour, much
the same as that displayed by veratrine _if mixed with sugar_ (Weppen’s
test, 1874). The resin of the drug may be prepared by exhausting
it with alcohol and precipitating with boiling acidulated water,
repeating the process in order to entirely eliminate the alkaloids. It
is a dark brown mass, yielding about a fourth of its weight to ether.
Scattergood obtained it to the extent of 4½ per cent. By exhausting the
drug successively with ether, absolute alcohol and spirit of wine, we
extracted from it not less than 31 per cent. of a soft resinoid mass.
Worthington pointed out the presence of gallic acid and of sugar.

[2599] _New England’s Rarities discovered_, Lond. 1672. 43; also
_Account of two Voyages to New England_, Lond., 1674, 60. 76.

[2600] _Travels in North America_, vol. ii. (1771) 91.

[2601] _Am. Journ. of Pharm._ iv. (1839) 89.

[2602] _Proc. of Am. Pharm. Assoc._ 1862. 226.

[2603] _Ibid._, 1877. 439. 523.

=Uses=—_Veratrum viride_ has of late been much recommended as a
cardiac, arteral and nervous sedative. It is stated to lower the pulse,
the respiration and beat of the body, not to be narcotic, and rarely
to occasion purging;[2604] but to what principle these effects are due
has not yet been ascertained. By some observers, as Bigelow,[2605]
Fée,[2606] Schroff,[2607] and Oulmont,[2608] it is alleged to have the
same medicinal powers as the European _Veratrum album_.


SEMEN SABADILLÆ.

_Fructus Sabadillæ_; _Cebadilla_, _Cevadilla_; F. _Cévadille_; G.
_Sabadillsamen_, _Läusesamen_.

=Botanical Origin=—_Asagræa officinalis_ Lindley (_Veratrum officinale_
Schlecht, _Sabadilla officinarum_ Brandt, _Schœnocaulon officinale_
A. Gray).—A bulbous plant, growing in Mexico, in grassy places on the
eastern declivities of the volcanic range of the Cofre de Perote, and
Orizaba, near Teosolo, Huatusco and Zacuapan, down to the sea-shore,
also in Guatemala. Cebadilla is (or was) cultivated near Vera Cruz,
Alvarado and Tlacatalpan in the Gulf of Mexico.

Another form of _Asagræa_, first noticed by Berg,[2609] but of late
more particularly by Ernst of Caracas, who thinks it may constitute
a distinct species, is found in plenty on grassy slopes, 3,500 to
4,000 feet above the sea-level, in the neighbourhood of Caracas, and
southward in the hilly regions bordering the valley of the Tuy.[2610]
It differs chiefly in having broader and more carinate leaves.[2611] Of
late years it has furnished large quantities of seed, which, freed from
their capsules, have been shipped from La Guaira to Hamburg.

[2604] Cutter, _Lancet_, Jan. 4, Aug. 16, 1862; _Pharm. Journ._ iv.
(1863) 134.

[2605] _American Medical Botany_, ii. (1819) 121-136.

[2606] _Cours d’Hist. Nat. Pharm._ i. (1828) 319.

[2607] _Medizinische Jahrbücher_, xix. (Vienna, 1863) 129-148.

[2608] Buchner’s _Repertorium für Pharmacie_, xviii. (1868) 50; also
Wiggers and Husemann’s _Jahresbericht_, xviii. 1868. 505.

[2609] Berg u. Schmidt, _Offiz. Gewächse_, i. (1858) tab. ix. e.
“_Sabadilla officinarum_.”

[2610] Ernst, communication to the Linnean Society of London, 15 Dec.,
1870.

[2611] _Veratrum Sabadilla_ Retzius is stated by Lindley (_Flora
Medica_, p. 586) to be a native of Mexico and the West Indian
Islands, and to furnish a portion of the cebadilla seeds of commerce.
The plant is unknown to us: we have searched for it in vain in the
herbaria of Kew and the British Museum. It is not mentioned as West
Indian by Grisebach (_Flor. of Brit. W. I. Islands_, 1864; _Cat.
Plant. Cubensium_, 1866). The figure by Descourtilz (_Flor. méd.
des Antilles_, iii. 1827. t. 1859) who had the plant growing at St.
Domingo, shows it to resemble _Veratrum album_ L., and therefore to be
very different from _Asagræa_.

=History=—Cebadilla was first described in 1517 by Monardes, who states
that it is used by the Indians of New Spain as a caustic and corrosive
application to wounds; but it does not seem to have been brought into
European commerce, for neither Parkinson who described it in 1640
as the _Indian Causticke Barley_, nor Ray (1693) did more than copy
from Monardes. It was regarded in Germany a rare drug even in 1726,
but in the latter half of the last century it began to be recommended
in France and Germany for the destruction of pediculi. A famous
composition for this purpose was the _Poudre des Capucins_, consisting
of a mixture of stavesacre, tobacco, and cebadilla, which was applied
either dry or made into an ointment with lard.[2612] Cebadilla was also
administered combined into a pill with gamboge and valerian,[2613] for
the destruction of intestinal worms, but its virulent action made it
hazardous.

Upon the introduction of veratrine into medicine about 1824 cebadilla
attracted some notice, and was occasionally prescribed in the form of
tincture and extract; but it subsequently fell into disuse, and is now
only employed for the manufacture of veratrine.

=Description=—Each fruit consists of three oblong pointed follicles,
about ½ an inch in length, surrounded below by the remains of the
6-partite calyx, and attached to a short pedicel. The follicles are
united at the base, spread somewhat towards the apex, and open by their
ventral suture. They are of a light brown colour and papery substance.
Each usually contains two-pointed narrow black seeds, ³/₁₀ of an inch
in length, which are shining, rugose, and angular or concave by mutual
pressure. The compact testa encloses an oily albumen, at the base of
which, opposite to the beaked apex, lies the small embryo. The seed
is inodorous and has a bitter acrid taste; when powdered, it produces
violent sneezing.

=Microscopic Structure=—A transverse section shows the horny
concentrically radiated albumen, closely attached to the testa. The
latter consists of an outer layer of cuboid cells, and three rows of
smaller, thin-walled, tangentially-extended cells, all of which have
brown walls. The tissue of the albumen is made up of large porous
cells, containing drops of oil, granules of albuminoid matter, and
mucilage. Traces of tannic acid occur only in the outer layers of the
seed.

=Chemical Composition=—Meissner, an apothecary of Halle, Prussia,
in 1819 discovered in cebadilla a basic substance, which he termed
_Sabadilline_; in publishing, in 1821, the description of it the
word “_alkaloid_” was introduced by Meissner at that occasion. The
name _Veratrine_[2614] was applied likewise in 1819 by Pelletier and
Caventou to a similar preparation. For many years this substance
was known only as an amorphous powder, in which state it frequently
contained a considerable proportion of resin; but in 1855 it was
obtained by G. Merck in large rhombic prisms. Cebadilla yields only
about 3 per mille of veratrine. The alkaloid is easily soluble in
spirit of wine, ether or chloroform; these solutions, as well as the
watery solutions of its salts, are devoid of rotatory power. Veratrine,
like the drug from which it is derived, occasions, if inhaled,
prolonged sternutation.

[2612] Murray, _Apparatus Medicaminum_, v. (1790) 171; Mérat and De
Lens, _Dict. Mat. Méd._ vi. (1834) 862.

[2613] Peyrilhe, _Cours. d’Hist. Nat. Méd._ ii. (1804) 490.

[2614] So called from Schlechtendal’s name for the plant, _Veratrum
officinale_.

Again, in 1834, Conerbe described an alkaloid from cebadilla under the
name of _Sabadilline_, and _Weigelin_ (1871) another called _Sabatrine_.

From the investigations of Wright and Luff (1878) it appears that the
above-mentioned statements must be resumed thus:—There are in cebadilla
three alkaloids, namely _Veratrine_, C₃₇H₅₃NO₁₁, _Cevadine_, C₃₂H₄₉NO₉,
and _Cevadilline_, C₃₄H₅₃NO₈, the second only being crystallizable.

Veratrin may be decomposed by means of caustic lye into a new alkaloid,
verine, and dimethyl-protocatechuic acid,

         {(OCH₃)₂
    C₆H₃ {
         {COOH

By the same treatment, cevadine yields an acid which appears to be
identical with tiglinic acid (page 566), and an alkaloid called cevine.

Cebadilla yielded to Pelletier and Caventou a volatile fatty acid,
_Sabadillic_ or _Cevadic Acid_, the needle-shaped crystals of which
fuse at 20° C. Lastly, E. Merck (1839) found a second peculiar acid
termed _Veratric Acid_, affording quadrangular prisms, which can be
sublimed without decomposition. It is yielded by cebadilla to the
extent of but ⅙ per mille. It has been shown in 1876 by Körner to be
identical with dimethyl-protocatechuic acid just mentioned (see also
our article _Tubera Aconiti_, p. 9).

=Commerce=—The quantity of cebadilla (_seeds_ only) shipped in 1876
from La Guaira, the port of Caracas, was 35,033 kilos., of which 25,966
went to Germany. No other sort is now imported.

=Uses=—Cebadilla is at present, we believe, only used as the source
of veratrine. In Mexico, the bulb of the plant is employed as an
anthelminthic, under the name of _Cebolleja_, but it is said to be very
dangerous in its action.


CORMUS COLCHICI.

_Tuber vel Bulbus vel Radix Colchici_; _Meadow Saffron Root_; F. _Bulbe
de Colchique_; G. _Zeitlosenknollen_.

=Botanical Origin=—_Colchicum autumnale_ L.—This plant grows in meadows
and pastures over the greater part of Northern Africa, Middle and
Southern Europe, and is plentiful in many localities in England and
Ireland. In the Swiss Alps, it ascends to an elevation of 5500 feet
above the sea-level.

=History=—Dioscorides drew attention to the poisonous properties
of Κολχικὸν, which he stated to be a plant growing in Messenia and
Colchis.[2615]

[2615] His description is exact, except that he declares the corm to
have a _sweet_ taste, which seems not true for _Colchicum autumnale_,
but may be so for some other species.

This character for deleterious qualities seems to have prevented
the use of colchicum both in classical and mediæval times. Thus
Tragus (1552) warns his readers against its use in gout, for which
it is recommended in the writings of the Arabians. Jacques Grévin,
a physician of Paris, author of _Deux Livres des Venins_, dedicated
to Queen Elizabeth of England, and printed at Antwerp in 1568,
observes—“ce poison est ennemy de la nature de l’homme en tout et
par tout.” Dodoens calls it _perniciosum Colchicum_; and Lyte in his
translation of this author (1578) says—“Medow or Wilde Saffron is
corrupt and venomous, therefore not used in medicine.” Gerarde declares
the roots of “_Mede Saffron_” to be “very hurtfull to the stomacke.”

Wedel published in 1718, at Jena, an essay _De Colchico veneno et
alexipharmaco_, in which, to show the great disfavour in which this
plant had been held, he remarks,—“hactenus ... velut infame habitum
et damnatum fuit colchicum, indignum habitum inter herbas medicas vel
officinales....” He further states that, in the 17th century, the corms
were worn by the peasants in some parts of Germany as a charm against
the plague.

In the face of these severe denunciations, it is strange to find that
in the London Pharmacopœia of 1618 (the second edition), “_Radix
Colchici_,” as well as _Hermodactylus_, is enumerated among the simple
drugs; and again in the editions of 1627, 1632 and 1639. It is omitted
in that of 1650, and does not reappear in subsequent editions until
1788, when owing to the investigations of Störck (1763), Kratochwill
(1764), De Berge (1765), Ehrmann (1772), and others, the possibility of
employing it usefully in medicine had been made evident.

=Development of the Corm=[2616]—At the period of flowering, the corm
is surrounded with a brown, closed double membrane or tunic, which
is prolonged upwards into a sheath around the flowering stem; at the
base of the corm is a tuft of simple roots. On removing the membranes,
we find a large, ovoid, fleshy body (Corm No. 1), marked at its apex
by a depressed scar, the point of attachment of the flower-stem of
the previous year; it is on one side flattened, and traversed by a
shallow longitudinal furrow, from the upper part of which arises a much
smaller and rudimentary corm (No. 2), bearing a flower-stem. After the
production of the flower in the autumn, Corm No. 2 increases in size,
throwing up as spring advances its fruit-stem and leaves, and acquires,
after these latter have come to maturity, its full development. Corm
No. 1 on the other hand, having performed its functions, shrivels and
diminishes in size, in proportion as No. 2 advances to maturity, and
ultimately decays, leaving a rounded cicatrix, showing its point of
attachment to its successor.

=Collection=—In England the corms are usually dug up and brought to
market in July, at the period between the decay of the foliage and the
production of the flower, or even after the latter has appeared. For
some preparations, they are used in the fresh state. If to be dried, it
is customary to slice them across thinly and evenly with a knife, and
to dry the slices quickly in a stove with a gentle heat; the membranes
are afterwards removed by sifting or winnowing.

Schroff has stated, as the result of his experiments,[2617] that the
corms possess the greatest medicinal activity when collected in the
autumn during or after inflorescence; that they ought to be dried
entire, by exposure to the sun and air; and that if thus preserved,
they lose none of their strength, even if kept for several years.

[2616] The term _corm_ is applied by English writers to the short,
fleshy, bulb-shaped base of an annual stem, either lateral as in
_Colchicum_, or terminal as in _Crocus_. By many continental botanists,
the corm of _Colchicum_ is regarded either as a form of tuber, or of
bulb.

[2617] _Oesterreichische Zeitschrift für praktische Heilkunde_, 1856,
Nos. 22-24; also Wiggers, _Jahresbericht der Pharm._ 1856. 15.

=Description=—The fresh corm is conical or inversely pear-shaped, about
2 inches long by an inch or more wide, rounded on one side, flattish
on the other, covered by a bright brown, membranous skin, within
which is a second of paler colour. When cut transversely, it appears
white, firm, fleshy and homogeneous, abounding in a bitter, starchy
juice, of disagreeable odour. The dried slices are inodorous, and have
a bitterish taste. They should be of a good white, clean, crisp and
brittle,—not mouldy or stained.

=Microscopic Structure=—The outer membrane is formed of
tangentially-extended cells, with thick brownish walls; the main body
of the corm, of large thin-walled, more or less regularly globular
cells, loaded with starch, and interrupted by vascular bundles
containing spiral vessels. The original form of the starch granules is
globular or egg-shaped, but from mutual pressure and agglutination,
many are angular or truncated. A large proportion are more or less
compound, consisting of several granules united into one. In all, the
hilum is very distinct, appearing in some as a mere point, but in most
as a line or star.

=Chemical Composition=—The corms contain _Colchicin_ (see next
article), starch, sugar, gum, resin, tannin, and fat. When sliced
and dried, they lose about 70 per cent. of water.[2618] By drying,
the (probably) volatile body upon which the odour of the fresh corm
depends, is lost.

=Uses=—Colchicum is much prescribed in cases of gout, rheumatism,
dropsy, and cutaneous maladies.

Other medicinal species of Colchicum.

Under the name _Hermodactylus_,[2619] the corms of other species of
_Colchicum_ of Eastern origin anciently enjoyed great reputation in
medicine. These corms are in structure precisely like those of ordinary
colchicum; they are entire, but deprived of membranous envelopes, of a
flattened, heart-shaped form, not wrinkled on the surface, and often
very small in size. The starch grains they contain are similar to those
of _C. autumnale_, but in some specimens twice as large.

There is a great uncertainty as to the species of _Colchicum_ which
furnish hermodactyls. Prof. J. E. Planchon, who has written an
elaborate article on the subject,[2620] is in favour of _C. variegatum_
L., a native of the Levant. But one can hardly suppose this plant to
be the source of the hermodactyls (_Sūrinjān_) of the Indian bazaars,
which are stated to be brought from Kashmir.

[2618] This is the average obtained during ten years in drying 16 cwt.,
in the laboratory of Messrs. Allen and Hanburys, London.

[2619] The _Bitter Hermodactyl_ of Royle is not in our opinion the
produce of a _Colchicum_ at all; see also Cooke in _Pharm. Journ._
April 1, 1871.

[2620] _Ann. des Sciences Nat._, Bot., iv. (1855) 132; abstract in
_Pharm. Journ._ xv. (1856) 465.


SEMEN COLCHICI.

_Colchicum Seed_; F. _Semence de Colchique_; G. _Zeitlosensamen_.

=Botanical Origin=—_Colchicum autumnale_ L., see page 699. The inflated
capsule, which grows up in the spring after the disappearance of the
flower in the autumn, is three-celled, dehiscent towards the apex by
its ventral sutures, and contains, attached to the inner angle of the
carpels, numerous globular seeds, which arrive at maturity in the
latter part of the summer.

=History=—Colchicum seeds were introduced into medical practice by Dr.
W. H. Williams, of Ipswich, about 1820, on the ground of their being
more certain in action than the corm.[2621] They were admitted to the
London Pharmacopœia in 1824.

=Description=—The seeds are of globose form, about ⅒ of an inch in
diameter, somewhat pointed by a strophiole, which when dry is not
very evident. They are rather rough and dull; when recent of a pale
brown, but become darker by drying, and at the same time exude a sort
of saccharine matter. They are inodorous even when fresh, but have a
bitter acrid taste; they are very hard and difficult to powder.

=Microscopic Structure=—The reticulated, brown coat of the seed
consists of a few rows of large, thin-walled tangentially-extended
cells, considerably smaller towards the interior, the outermost
containing starch grains in small number. The thin testa is closely
adherent to the horny greyish albumen. The cells of the latter are
remarkable for their thick walls, showing wide pores; they contain
granular plasma and oil-drops. The very small leafless embryo may be
observed on transverse section close beneath the testa on the side
opposite the strophiole.

=Chemical Composition=—The active principle of colchicum seed is
termed _Colchicin_, but the chemists who have made it the subject
of investigation are not agreed as to its properties. Thus Oberlin
(1856) showed it to contain nitrogen, but without possessing basic
properties. By treatment with acids, the amorphous colchicin yields a
crystallizable body, _Colchiceïn_. Hübler (1864) prepared colchicin
in the same way by which the so-called “bitter principles,” like
dulcamarin (p. 451) are obtainable. He assigned to colchiceïn acid
qualities and, strangely enough, the same formula he gave for colchicin
itself, namely C₁₇H₁₉NO₅. Maisch[2622] as well as Diehl[2623] again
obtained discrepant results. _Colchicin_ of definite composition has
not yet been isolated.

[2621] _London Medical Repository_, Aug. 1, 1820.

[2622] _Pharm. Journ._ ix. (1867) 249.

[2623] _Proc. Americ. Pharm. Assoc._ 1867. 363.

It would appear that in an aqueous or alcoholic extract of the seed
an extremely small amount of an alkaloid is present, but that a basic
substance is immediately formed on addition of mineral acids, or
also oxalic acid. This suggestion is to some extent supported by the
following facts:—

By adding the usual test solution for alkaloids, _i.e._ iodohydrogyrate
of potassium (50 grammes of iodide of potassium, 13·5 of perchloride of
mercury in one litre), to an aqueous solution of an alcoholic extract
of the seeds, a very slight turbidity, or an insignificant precipitate
is observed. Yet on addition of sulphuric, or nitric, or hydrochloric
acid, an abundant precipitate of a beautiful yellow is at once
produced. This experiment succeeds with a few seeds, either entire or
powdered; it may be conveniently applied for the detection of colchicum
in any preparation. We have ascertained that the yellow precipitate
can be obtained also with the other parts of the plant. If the yellow
compound is decomposed by sulphuretted hydrogen, the filtrate, after
due concentration, now precipitates immediately on addition of the
iodohydrogyrate, yet still more abundantly in presence of a mineral
acid.

The seeds contain traces of gallic acid, much sugar and fatty oil. Of
the last we obtained 6·6 per cent. by exhausting the dried seed with
ether. The oil concreted at -8° C. Rosenwasser (1877) obtained 8·4 per
cent. of the oil.

=Uses=—The same as those of the corm.




SMILACEÆ.


RADIX SARSAPARILLÆ.

_Radix Sarzæ vel Sarsæ_; _Sarsaparilla_; F. _Racine de Salsepareille_;
G. _Sarsaparillwurzel_.

=Botanical Origin=—Sarsaparilla is afforded by several plants of the
genus _Smilax_, indigenous to the northern half of South America,
and the whole of Central America as far as the southern and western
coast-lands of Mexico.

These plants are woody climbers, often ascending lofty trees by the
strong tendrils which spring from the petiole of the leaf. Their stems
are usually angular, armed with stout prickles, and thrown up from a
large woody rhizome. The medicinal species inhabit swampy tropical
forests, which are extremely deleterious to the health of Europeans,
and can only be explored amid great difficulties. This circumstance
taken in connexion with the facts that the plants are diœcious, that
their scandent habit often renders their flowers and fruits (produced
at different seasons) inaccessible, and that their leaves vary
exceedingly in form,[2624] explains why we are but very imperfectly
acquainted with the botanical sources of sarsaparilla.

[2624] The common _Smilax aspera_ L., of Southern Europe, is a plant
which presents such diversity of foliage, that if like its congeners of
Tropical America, it were known only by a few leafy scraps preserved in
herbaria, it would assuredly have been referred to several species.

It is not too much to assert that the sarsaparilla plant of no district
in Tropical America is scientifically well known. The species moreover,
to which the drug is assigned, have for the most part been founded upon
characters that are totally insufficient, so that after an attentive
study of herbarium specimens, we are obliged to regard as still
doubtful several of the plants that have been named by previous writers.

Having made these preliminary remarks, we will enumerate the plants to
which the sarsaparilla of commerce has been ascribed.

1. _Smilax officinalis_ H.B.K.—This plant was obtained in the year
1805, by Humboldt, at Bajorque, a village since swept away by the
stream, about in 7° N. lat., on the Magdalena in New Granada. The
specimens, comprising only a few imperfect leaves, which we have
examined in the National Herbarium of Paris, are the materials upon
which Kunth founded the species. Humboldt[2625] states, that quantities
of the root are shipped by way of Mompox and Cartagena to Jamaica and
Cadiz.

In 1853 this plant was again gathered at Bajorque by the late De
Warszewicz, who sent to one of us (H.) leaves and stems, accompanied
by the root, which latter agrees with the _Jamaica Sarsaparilla_
of commerce. But at Bajorque the root is no longer collected for
exportation.

The same botanical collector, at the request of one of us, obtained in
the year 1851, on the volcano and Cordillera of Chiriqui in Costa Rica,
fruits, leaves, stems, and roots, of the plant there collected by the
Indians as _Sarsa peluda_ or _Sarson_. These specimens agree, so far
as comparison is possible, with those of the Bajorque plant, while the
root is undistinguishable from the Jamaica sarsaparilla of the shops.
Other specimens of the same plant, gathered by the same collector
in 1853, were forwarded to England with a living root, which latter
however could not be made to grow.

Finally, in 1869, Mr. R. B. White obligingly communicated to us leaves
and roots of a sarsaparilla collected at Patia in New Granada, which
apparently belongs to the same species.

In the island of Jamaica, there has been cultivated for many years,
and of late with a view to medicinal use, a sarsaparilla plant which
appears to be _Smilax officinalis_. The specimens transmitted to
us[2626] include neither flowers nor fruits; but the leaves and square
stem accord exactly with those of the plant collected at Bajorque. The
root is of a light cinnamon-brown, and far more amylaceous than the
so-called _Jamaica Sarsaparilla_ of commerce (see p. 710).

2. _Smilax medica_ Schl. et Cham.—This species,[2627] which was
discovered in Mexico by Schiede in 1820, is without doubt the source of
the sarsaparilla shipped from Vera Cruz. According to our observations,
it has a flexuose (or zigzag) stem, and much smaller foliage than
_S. officinalis_; the leaves, though very variable, often assume an
auriculate form, with broad, obtuse, basal lobes.

It grows on the eastern slopes of the Mexican Andes, and is the only
species of that region of which the roots are collected. These,
according to Schiede, are dug up all the year round, dried in the sun
and made into bundles.

[2625] Kunth, _Synopsis Plant._ i. (1822) 278.—_Smilax officinalis_
is a large, strong climber, attaining a height of 40 to 50 feet,
with a perfectly square stem armed with prickles at the angles. The
leaves are often a foot in length, of variable form, being triangular,
ovate-oblong, or oblong-lanceolate, either gradually narrowing towards
the apex or rounded and apiculate, and at the base either attenuated
into the petiole, or truncate, or cordate. They are usually 5-nerved,
the 3 inner nerves being prominent and enclosing an elliptic area. The
flowers are in stalked umbels. A fine specimen of the plant is most
luxuriantly growing since many years in the Royal Gardens, Kew, but has
not flowered.

[2626] We owe them to the kindness of H. J. Kemble, Esq., who procured
them, with specimens of the root, from the Government garden at
Castleton.

[2627] Figured in Nees von Esenbeck’s _Plantæ Medicinales_, suppl. tab.
7.

Doubt and confusion hang over the other species of _Smilax_ which have
been quoted as the sources of sarsaparilla. _S. syphilitica_ H.B.K.,
with flowers in a raceme of umbels, discovered on the Cassiquiare in
New Granada, and well figured by Berg and Schmidt from an authentic
specimen, appears from Pöppig’s statements to yield some of the
sarsaparilla shipped at Pará. But Kunth states that Pöppig’s plant,
gathered near Ega, is not that of Humboldt and Bonpland. Spruce, who
collected _S. syphilitica_ (herb. No. 3779) in descending the Rio Negro
in 1854, has informed us that the Indians in various places in the
Amazon valley always strenuously asserted it to be a species worthless
for “_Salsa_.”

_S. papyracea_, described by Poiret[2628] in 1804, and figured by
Martius,[2629] is but very imperfectly known. It has foliage resembling
that of _S. officinalis_, but, judging from Spruce’s specimens (No.
1871) collected on the Rio Negro, a _multangular_ stem. It is probably
the source of the _Pará Sarsaparilla_.

_S. cordato-ovata_ Rich. is a doubtful plant, perhaps identical with
_S. Schomburgkiana_ Knth., a Panama species. Pöppig alleges that its
root is mixed with that of the plant which he calls _S. syphilitica_.

_S. Purhampuy_ Ruiz, a Peruvian species, said to afford a valuable
sort of sarsaparilla, is practically unknown, and is not admitted by
Kunth.[2630]

No new information on the several above mentioned species of Smilax is
found in the review of this genus by A. and C. De Candolle,[2631] where
105 American species are enumerated.

=History=—Monardes[2632] has recorded that sarsaparilla was first
introduced to Seville about the year 1536 or 1545, from New Spain; and
a better variety soon afterwards from Honduras. He further narrates
that a drug of excellent quality was subsequently imported from the
province of Quito, that it was collected in the neighbourhood of
Guayaquil, and was of a dark hue, and larger and thicker than that of
Honduras.

Pedro de Cieza de Leon, in his Chronicle of Peru,[2633] which contains
the observations made by him in South America between 1532 and 1550,
gives a particular account of the sarsaparilla which grows in the
province of Guayaquil and the adjacent island of Puna, and recommends
the sudorific treatment of syphilis, exactly as pursued at the present
time.

These statements are confirmed by the testimony of other writers.
Thus, João Rodriguez de Castello Branco, commonly known as Amatus
Lusitanus, a Portuguese physician of Jewish origin, who practised
chiefly in Italy, has left a work recording his medical experiences
and narrating cases of successful treatment.[2634] One of the latter
concerns a patient suffering from acute rheumatism, for whom he finally
prescribed _Sarsaparilla_. This drug, he explains, has of late years
been brought from the newly found country of Peru, that it is in long
whip-like roots, growing from the stock of a sort of bramble resembling
a vine, that the Spaniards call it _Zarza parrilla_, and that it is an
excellent medicine.

[2628] Lamarck, _Encyclopédie méthodique_, Bot., vi. 1804. 468.

[2629] _Flor. Bras._ i. (1842-71) tab. 1.

[2630] It must not be supposed that _all_ species of _Smilax_ are
capable of furnishing the drug. There are many, even South American,
which like the _S. aspera_ of Europe, have _thin, wiry_ roots, which
would never pass for medicinal sarsaparilla.

[2631] _Monographiæ phanerogamarum_, i. (1878) 6-199.

[2632] Pages 18 and 88 of the work quoted in the Appendix.

[2633] _Parte primera de la Chronica del Peru_, Sevilla, 1553, folio
lxix.—a translation for the Hakluyt Society in 1864, by Markham, who
observes that Cieza de Leon never himself visited Guayaquil.

[2634] _Curationum medicinalium centuriæ quatuor_, Basileæ, 1556. 365.

About the same period, sarsaparilla was described by Auger
Ferrier,[2635] a physician of Toulouse, who states that in the
treatment of syphilis, which he calls _Lues Hispanica_, it is believed
to be better than either _China root_ or _Lignum sanctum_. Girolamo
Cardano of Milan, in a little work called _De radice Cina et Sarza
Parilia judicium_,[2636] expresses similar opinions. After so strong
recommendations, the drug soon found its way to the pharmaceutical
stores; we find it quoted for instance in 1563, in the tariff of the
“Apotheke” of the little town of Annaberg in Saxony.[2637] We have
also noticed “Sarsaparilla” in the _Ricettario Fiorentino_ of the year
1573.[2638] Gerarde,[2639] who wrote about the close of the century,
states that the sarsaparilla of Peru is imported into England in
abundance.

=Collection of the Root=—Mr. Richard Spruce, the enterprising botanical
explorer of the Amazon valley, has communicated to us the following
particulars on this subject, which we give in his own graphic words:—

“When I was at Santarem on the Amazon in 1849-50, where considerable
quantities of sarsaparilla are brought in from the upper regions of
the river Tapajóz, and again when on the Upper Rio Negro and Uaupés
in 1851-53, I often interrogated the traders about their criteria of
the good kinds of sarsaparilla. Some of them had bought their stock
of Indians of the forest, and had themselves no certain test of its
genuineness or of its excellence, beyond the size of the roots, the
thickest fetching the best price at Pará. Those who had gathered
sarsaparilla for themselves were guided by the following characters:—1.
Many stems from a root. 2. Prickles closely set. 3. Leaves thin.—The
first character was (to them) alone essential, for in the species of
_Smilax_ that have solitary stems, or not more than two or three,
the roots are so few as not to be worth grubbing up; whereas the
multicaul species have numerous long roots,—three at least to each
stem,—extending horizontally on all sides.

“In 1851, when I was at the falls of the Rio Negro, which are crossed
by the equator, nine men started from the village of St. Gabriel to
gather _Salsa_, as they called it, at the head of the river Cauaburís.
During their absence I made the acquaintance of an old Indian, who
told me that four years ago he had brought stools of _Salsa_ from the
Cauaburís and had planted them in a _tabocál_,—a clump of bamboos,
indicating the site of an ancient Indian village,—on the other side of
the falls, whither he invited me to go and witness the gathering of
his first crop of roots. On the 23rd March, I visited the _tabocál_,
and found some half-dozen plants of a _Smilax_ with very prickly
stems, but no flowers or fruit. At my request the Indian operated on
the finest plant first. It had five stems from the crown, and numerous
roots about 9 feet long, radiating horizontally on all sides. The thin
covering of earth was first scraped away from the roots by hand, aided
by a pointed stick; and had the _salsa_ been the only plant occupying
the ground, the task would have been easy. But the roots of the _salsa_
were often difficult to trace among those of bamboo and other plants,
which had to be cut through with a knife whenever they came in the way.
The roots being at length all laid bare—(in this case it was the work
of half a day, but with large plants it sometimes takes up a whole day
or even more)—they were cut off near the crown, a few slender ones
being allowed to remain, to aid the plant in renewing its growth. The
stems also were shortened down to near the ground, and a little earth
and dead leaves heaped over the crown, which would soon shoot out new
stems.

[2635] _De Pudendagra lue Hispanica, libri duo_, first published at
Toulouse in 1553, and many times reprinted. We have consulted the
Antwerp edition of 1564, with which Cardano’s work is printed. The
latter is said to have first appeared in 1559.

[2636] Basileæ, 1559, fol.

[2637] Flückiger, _Documente_ (quoted at p. 404, note 7) 24.

[2638] See Appendix.

[2639] _Herball_, enlarged by Johnson, 1636. 859.

“The yield of this plant, of four years’ growth, was 16 lb.—half a
Portuguese _arroba_—of roots; but a well grown plant will afford at the
first cutting from one to two arrobas. In a couple of years, a plant
may be cut again, but the yield will be much smaller and the roots more
slender and less starchy.”

=General Description=—The medicinal species of _Smilax_ have a thick,
short, knotty rhizome, called by the druggists _chump_, from which grow
in a horizontal direction long fleshy roots, from about the thickness
of a quill to that of the little finger. These roots are mostly simple,
forked only towards their extremities, beset with thread-like branching
rootlets of nearly uniform size, which however are not emitted to any
great extent from the more slender part of the root near the stock.
When fresh the root is plump,[2640] but as found in commerce in the
dried state it is more or less furrowed longitudinally, at least in the
vicinity of the rhizome. When examined with a good lens both roots and
rootlets may be seen in some specimens to be clothed with short velvety
or shaggy hairs.

The presence or absence in greater or less abundance of starch in the
bark of the root is regarded as an important criterion in estimating
the good quality of sarsaparilla. In England the non-amylaceous or
non-mealy roots are preferred, they alone being suitable for the
manufacture of the dark fluid extract that is valued by the public. On
the Continent, and especially in Italy, sarsaparilla, which when cut
exhibits a thick bark, pure white within, is the esteemed kind.

The more or less plentiful occurrence of starch in the roots of
_Smilax_ is a character which has no botanical significance, and
appears, indeed, to vary in the same species. If one examines Jamaica
sarsaparilla by shaving off a little of the bark, one finds a large
majority of roots to be non-amylaceous in their entire length; but
others can be picked out which, though non-amylaceous for some distance
from the rhizome, acquire a starchy bark, which is _white_ internally
in their middle and lower portions;—and there are still others which
are slightly starchy even as they start from the parent rhizome,
becoming still more as they advance. In Guatemala sarsaparilla, which
is considered a very mealy sort, it is easy to perceive that the bark
is hardly amylaceous in the vicinity of the rhizome, but that it
acquires an enormous deposit of fecula as it proceeds in its growth.

[2640] We have been kindly permitted to examine the fresh root of the
large plant of _Smilax officinalis_ in the Royal Gardens, Kew; and
have found that it agrees in appearance and in structure with Jamaica
sarsaparilla.

Sarsaparilla varies greatly in the abundance of rootlets, technically
called _beard_, with which the roots are clothed. This character
depends partly on natural circumstances, and partly on the practice
of the collectors who remove or retain the rootlets at will. Dr. Rhys
of Belize has stated that the proportion of rootlets depends much on
the nature of the soil, their development being most favoured by moist
situations.

Dry sarsaparilla has not much smell, yet when large quantities are
boiled, or when a decoction is evaporated, a peculiar and very
perceptible odour is emitted. The taste of the root is earthy, and not
well marked, and even a decoction has no very distinctive flavour.

=Microscopic Structure=[2641]—On a _transverse section_ of the root,
its fibro-vascular bundles are seen to be restricted to the central
part, being all enclosed by a brown ring. Within this ring the bundles
are densely packed so as to form a ligneous zone. The very centre
of the section consists of white medullary tissue, through which
sometimes a certain number of fibro-vascular bundles are scattered.
A similar medullary parenchyme is met with between the brown ring or
nucleus-sheath or the epidermis. On a _longitudinal section_ the latter
exhibits several rows of elongated cells, having their outer brown
walls thickened by secondary deposits. The brown nucleus-sheath, on the
other hand, consists of only one row of prismatic cells, their inner
and lateral walls alone having secondary deposits. The vascular bundles
contain large scalariform vessels and lignified prosenchymatous cells.

The parenchymatous cells, if not devoid of solid contents, are loaded
with large compound starch granules; some cells also exhibit bundles
of acicular crystals of calcium oxalate. In non-mealy sarsaparilla the
vessels and ligneous cells sometimes contain a yellow resin.

The various sorts of sarsaparilla differ, not only in being mealy or
non-mealy, but also as regards the thickness of the ligneous zone,
which in some of them is many times thinner than the diameter of
the central medullary tissue. In other kinds this diameter is very
much smaller. Yet the nucleus-sheath affords still better means for
distinguishing the sorts of this drug, if we examine its single cells
in a transverse section. The outline of such a cell may be of a square
or somewhat rounded shape, or it may be more or less extended. In
this case it may be extended in the direction of a radius, or in the
direction of a tangent. The secondary deposits may vary in thickness.

=Sorts of Sarsaparilla=—In the present state of our knowledge no
botanical classification of the different kinds of sarsaparilla being
possible, we shall resort to the arrangement adopted by Pereira and
place them in two groups,—the _mealy_, or those of which starch is a
prevalent constituent, and the _non-mealy_, or those in which starch
exists to a comparatively small extent.

[2641] For more particulars consult Vandercolme, _Histoire bot. et
thérapeut. des Salsepareilles_, Paris, 1870, 127 pp., 3 plates; and
Otten, in Dragendorff’s _Jahresbericht_, 1876. 74.

(A.) _Mealy Sarsaparillas._

1. _Honduras Sarsaparilla_—This drug is exported from Belize. It is
made up in hanks or rolls about 30 inches long and 2½ to 4 inches or
more in diameter, closely wound round with a long root so as to form a
neat bundle. The hanks are united into bales by large pieces of hide,
placed at top and bottom, and held together with thongs of the same,
further strengthened with iron hoops.

The roots are deeply furrowed, or sometimes plump and smooth, more or
less provided with _beard_ or rootlets. In a very large proportion of
their length they exhibit when cut a thick bark loaded with starch; yet
in those parts which are near the rhizome the bark is brown, resinous,
and non-amylaceous. They are of a pale brown, sometimes verging into
orange. But the drug is subject to great variation, so that it is
impossible to lay down absolutely distinctive characters.

The annual imports into the United Kingdom of sarsaparilla from British
Honduras during the five years ending with 1870 averaged about 52,000
lb.

2. _Guatemala Sarsaparilla_—This sort of sarsaparilla, which first
appeared in commerce about 1852, resembles the Honduras kind in
many of its characters, and is packed in a similar manner. But it
has a more decided _orange hue_; the roots as they start from the
rhizome are lean, shrunken, and but little starchy, but they become
gradually stouter (³/₁₀ inch diam.), and acquire a thick bark, which
is internally very white and mealy. There is a tendency in the bark of
this sarsaparilla to crack and split off, so that bare spaces showing
the central woody column are not unfrequent.

According to Bentley,[2642] who examined specimens of the plant, this
drug is derived from _Smilax papyracea_; we are not prepared to agree
in this opinion.

3. _Brazilian, Para or Lisbon Sarsaparilla_—Though formerly held in
high esteem Brazilian sarsaparilla is not now appreciated in England,
and is rarely seen in the London market.[2643] It is packed in a
very distinctive manner, the roots being tightly compressed into a
cylindrical bundle, 3 feet or more in length and about 6 inches in
diameter, firmly held together by the flexible stem of a bignoniaceous
plant, closely wound round them, the ends being neatly shaved off.

[2642] _Pharm. Journ._ xii. (1853) 470, with figure.

[2643] We noticed 66 rolls of it from Pará, offered for sale 15 Dec.
1853.—D. H.


(B.) _Non-mealy Sarsaparillas._

4. _Jamaica Sarsaparilla_—To the English druggist this is the most
important variety; it is that which appears to have the greatest claim
to possess some medicinal activity, and it is the only sort admitted
to the _British Pharmacopœia_. Although constantly called _Jamaica
sarsaparilla_, it is well known that it only bears the name of Jamaica
through having been formerly shipped from Central America by way of
that island.[2644] At the commencement of the last century, Jamaica was
an emporium for sarsaparilla, great quantities of which, according to
Sloane,[2645] were brought thither from Honduras, New Spain and Peru.
Its actual place of growth, according to De Warszewicz (1851), is the
mountain range known as the Cordillera of Chiriqui, in that part of the
isthmus of Panama adjoining the republic of Costa Rica: here the plant
grows at an elevation of 4000 to 8000 feet above the level of the sea.
The root is brought by the natives to Boca del Toro on the Atlantic
coast for shipment.

The drug consists of roots, 6 feet or more in length, bent repeatedly
so as to form bundles of 18 inches long, and 4 in diameter, which
are secured by being twined round (but less trimly and closely than
the Honduras sort) with a long root of the same drug. The rhizome is
entirely absent, but the fibre or beard is preserved, and is reckoned a
valuable portion of the drug. The roots are deeply furrowed, shrunken,
and generally more slender than in the Honduras kind; the bark when
shaved off with a penknife is seen to be brown, hard and non-mealy
throughout. Yet it is by no means uncommon to find roots which have a
smooth bark rich in starch. In colour, Jamaica sarsaparilla varies from
a pale earthy brown to a deeper more ferruginous hue, the latter tint
being the most esteemed.

The sarsaparilla referred to at p. 704 as grown in the island of
Jamaica, is a well prepared drug, yet so pale in colour and so
amylaceous, that it finds but little favour in the English market.
There were exported of it from Jamaica in 1870, 1747 lb.,[2646] in
1871, 1290 lb.

5. _Mexican Sarsaparilla_—The roots of this variety are not made into
bundles, but are packed in straight lengths of about 3 feet into bales,
the chump and portion of an angular (but not _square_) thorny stem
being frequently retained. The roots are of a pale, dull brown, lean,
shrivelled, and with but few fibres. When thick and large, they have
a somewhat starchy bark, but when thin and near the rhizome, they are
non-amylaceous.

6. _Guayaquil Sarsaparilla_—An esteemed kind of sarsaparilla has long
been exported from Guayaquil (p. 705). Mr. Spruce has informed us that
it is obtained in most of the valleys that debouch into the plain on
the western side of the Equatorial Andes, but chiefly in the valley
of Alausi, where, in 1859, he saw plants of it at the junction of the
small river Puma-cocha with the Yaguachi. The plant appears to be very
productive, an instance being on record of as much as 75 lb. of fresh
roots having been obtained from a single stock.[2647]

[2644] The connexion between Jamaica and Central America dates back
from the time of Charles II., during whose reign (1661-85), the king of
the Mosquito Territory, a district never conquered by the Spaniards,
applied to the governor of Jamaica for protection, which was accorded.
The protectorate lasted until 1860, when Mosquitia was ceded to the
government of Nicaragua.

[2645] _Nat. Hist. of Jamaica_, i. (1707), introduction, p. lxxxvi.

[2646] _Blue Books—Island of Jamaica_ for 1870 and 1871.

[2647] _Journ. of Linn. Soc._, Bot., iv. (1860) 185.

Guayaquil sarsaparilla differs considerably from the sorts previously
noticed. It is rudely packed in large bales, and is not generally made
into separate hanks. The rhizome (chump) and a portion of the stem are
often present, the latter being _round_ and not prickly. The root is
dark, large and coarse-looking, with a good deal of fibre. The bark is
furrowed, rather thick, and not mealy in the slenderer portions of the
root which is near the rootstock; but as the root becomes stout, so its
bark becomes smoother, thicker and amylaceous, exhibiting when cut a
fawn-coloured or pale yellow interior.

The quantity exported from Guayaquil in 1871 was 1017 quintals, value
£3814.[2648]

=Chemical Composition=—Galileo Pallotta, at Naples, in 1824, first
attempted to obtain from sarsaparilla a peculiar principle, which he
believed to be an alkaloid, and termed _Pariglina_, or as now written
_Parillin_. He exhausted the crude drug with boiling water and mixed
the decoction with milk of lime, whereby a greyish precipitate was
produced. This was dried, and treated with hot alcohol which extracted
the parillin. Pallotta says the substance slightly reddens litmus,
but does not explicitly state whether he got it in crystals or not.
Berzelius in 1826 replaced the name pariglina by _Smilacin_. The same
substance was obtained, more or less pure, by Thubeuf in 1831 and
called _Salseparin_; Batka in 1833 termed it _Parillinic acid_. We
have isolated parillin[2649] by exhausting Mexican sarsaparilla with
boiling alcohol, 0·835 sp. gr., and evaporating the tincture to ⅙ of
the weight of the root. By diluting 2 parts of the residue with 3 parts
of cold water, a yellowish deposit of crude parillin is formed and may
be separated after a few days by decantation. The deposit is then mixed
with about half a volume of strong alcohol, now filtered and washed
with dilute alcohol, about 0·965 sp. gr. It may further be purified
by repeated recrystallization from dilute alcohol and the use of a
little charcoal. The yield is about 0·19 per cent. of perfectly white
crystallized parillin; a little more may be removed from the washings,
but with much difficulty. These liquids and the mother-liquors may be
concentrated and boiled with a little sulphuric acid in order to afford
parigenin.

[2648] Vice-Consul Smith on the commerce of Ecuador—_Consular Reports_,
presented to Parliament, July, 1872.

[2649] _Yearbook of Pharm._ 1878. 136.

Parillin forms brilliant scales, or can be obtained in thin prisms from
boiling alcohol 0·965 sp. gr. Parillin is almost insoluble in cold
water, but dissolves in 20 parts of boiling water. On cooling, the
latter solution affords no crystals; an abundance of them are however
produced on addition of alcohol. Parillin is also soluble in 25 parts
of alcohol, 0·814 sp. gr., at 25° C., and much more abundantly in
boiling alcohol, from which it partly separates in crystals on cooling.
In both absolute alcohol or water, parillin is less soluble than in
dilute alcohol. Hence aqueous solutions are precipitated by absolute
alcohol, and parillin, on the other hand, separates from alcoholic
solutions on addition of cold water. With chloroform, parillin yields a
viscid solution which affords no crystals.

The alcoholic solutions of parillin have a somewhat acrid taste, and
are devoid of rotatory power.

By dilute mineral acids, parillin is resolved into _Parigenin_ and
sugar; the liquid gradually acquires a dingy brown or greenish hue and
fluorescence, which is most obvious if parillin dissolved in chloroform
is decomposed by hydrochloric gas. Parigenin is easily isolated; it is
insoluble even in boiling water, but crystallizes in white scales from
alcohol.

The composition of parillin and parigenin is not settled; the former
belongs to the class of saponin. Yet parillin differs from saponin as
contained in Saponaria or Quillaja[2650] by not being sternutatory; its
solutions froth when shaken.

The presence in sarsaparilla of starch, resin, and calcium oxalate, as
revealed by the microscope, has been already pointed out. Pereira[2651]
examined the _essential oil_, which is heavier than water and has the
odour and taste of the drug; 140 lb. of Jamaica sarsaparilla afforded
of it only a few drops.

The nature of the dark extractive matter which water removes from
the root in abundance, and the proportion of which is considered by
druggists a criterion of goodness, has not been studied.

=Commerce=—The importation of sarsaparilla into the United Kingdom in
1870 (later than which year we have no returns) amounted to 345,907
lb., valued at £26,564.

=Uses=—Sarsaparilla is regarded by many as a valuable alterative and
tonic, but by others as possessing little if any remedial powers. It is
still much employed, though by no means so extensively as a few years
ago. The preparations most in use are those obtained by a prolonged
boiling of the root in water.


TUBER CHINÆ.

_Radix Chinæ_; _China Root_; F. _Squine_; G. _Chinawurzel_.

=Botanical Origin=—_Smilax China_ L., a woody, thorny, climbing
shrub, is commonly said to afford this drug. The plant is a native
of Japan, the Loochoo islands, Formosa, China, Cochin China, also of
Eastern India, as Kasia, Assam, Sikkim, Nepal. The chief authority for
attributing the China root to this plant is Kämpfer, who saw the latter
in Japan and figured it.[2652]

_S. glabra_ Roxb. and _S. lanceæfolia_ Roxb., natives of India and
Southern China, have tubers which, according to Roxburgh, cannot be
distinguished from the China root of medicine, though the plants are
perfectly distinct in appearance from _S. China_. Dr. Hance,[2653] of
Whampoa, received a living specimen of China root, which proved to be
that of _S. glabra_. The three above-named species all grow in the
island of Hongkong.

[2650] See Christophson, in Dragendorff’s _Jahresbericht_, 1874. 155.

[2651] _Elements of Mat. Med._ ii. (1850) 1168.

[2652] “_Sankira_,” p. 783 in the first work quoted in the Appendix;
another fig. will be found in Nees von Esenbeck’s _Plantæ medicinales_,
Düsseldorf, 1828.

[2653] Trimen’s _Journ. of Bot._ i. (1872) 102.—_S. glabra_ and _S.
lanceæfolia_ have been figured by Seemann in his _Botany of the
Herald_, 1852-57, tabb. 99-100. _S. China_ is well represented in
the Kew Herbarium, where we have examined specimens from Nagasaki,
Hakodadi, and Yokohama; from Loochoo, Corea, Formosa, Ningpo; and
Indian ones from Khasia, Assam, and Nepal.

=History=—The use of this drug as a remedy for syphilis was made known
to the Portuguese at Goa by Chinese traders about A.D. 1535. Garcia de
Orta, who makes this statement, further narrates that so great was the
reputation of the new drug, that the small quantities first brought to
Malacca were sold at the rate of 10 crowns per _ganta_, a weight of 24
ounces.

Possibly the drug found its way to Europe even before that year, for
we find a careful description of it in the posthumous works[2654] of
Valerius Cordus and Walther Ryff[2655] states in 1548 that the root was
brought a few years ago to Venice.

The reported good effects of China root on the Emperor Charles V. who
was suffering from gout, acquired for the drug a great celebrity in
Europe, and several works[2656] were written in praise of its virtues.
But though its powers were soon found to have been greatly overrated,
it still retained some reputation as a sudorific and alterative,
and was much used at the end of the 17th century in the same way as
sarsaparilla. It still retains a place in some modern pharmacopœias.

[2654] Edit. by Conrad Gesner, fol. 212 of the work quoted in the
Appendix.

[2655] ... _Bericht der Natur ... der Wurtzel China_, Würzburg, 1548.
4°.

[2656] The earliest of which is by Andreas Vesalius, _Epistola
rationem, modumque pro pinandi radicis_ Chymae (sic!) _decocti, quo
nuper invictissimus Carolus V. imperator usus est_, Venet., 1546.

=Description=—The plant produces stout fibrous roots, here and there
thickened into large tubers, which when dried become the drug China
root. These tubers, as found in the market, are of irregularly
cylindrical form, usually a little flattened, sometimes producing short
knobby branches. They are from about 4 to 6 or more inches in length,
and 1 to 2 inches in thickness, covered with a rusty-coloured, rather
shining bark, which in some specimens is smooth and in others more or
less wrinkled. They have no distinct traces of rudimentary leaves,
which however are perceptible on those of some allied species. Some
still retain portions of the cord-like woody runners on which they
grew; the bases of a few roots can also be observed. The tubers mostly
show marks of having been trimmed with a knife.

China root is inodorous and almost insipid. A transverse section
exhibits the interior as a dense granular substance of a pale fawn
colour.

=Microscopic Structure=—The outermost cortical layer is made up of
brown, thick-walled cells, tangentially-extended. They enclose numerous
tufts of needle-shaped crystals of calcium oxalate, and reddish-brown
masses of resin. The bark is at once succeeded by the inner parenchyme
which contrasts strongly with it, consisting of large, thin-walled,
porous cells which are completely gorged with starch, but here and
there contain colouring matter and bundles of crystals. The starch
granules are large (up to 50 mkm.), spherical, often flattened and
angular from mutual pressure. Like those of colchicum, they exhibit
a radiate hilum: very frequently they have burst and run together,
probably in consequence of the tubers having been scalded. The vascular
bundles scattered through the parenchyme, contain usually two large
scalariform or reticulated vessels, a string of delicate thin-walled
parenchyme, and elegant wood-cells with distinct incrusting layers and
linear pores.

=Chemical Composition=—The drug is not known to contain any substance
to which its supposed medicinal virtues can be referred. We have
endeavoured to obtain from it _Parillin_, the crystalline principle of
sarsaparilla, but without success.

=Commerce=—China root is imported into Europe from the South of
China—usually from Canton. The quantity shipped from that port in
1872, was only 384 peculs (51,200 lb.); while the same year there was
shipped from Hankow, the great trading city of the Yangtsze, no less
than 10,258 peculs (1,367,733 lb.), all to Chinese ports. For the
year 1874, these figures were: Hankow 9393 peculs, valued at 53,194
taels (one tael about 5_s._ 10_d._), Kewkiang 3627 peculs, Ningpo 2905
peculs,[2657] and for 1877 Hankow 12,075 peculs, Kewkiang 3942 peculs.

=Uses=—Notwithstanding the high opinion formerly entertained of the
virtues of China root, it has in England fallen into complete disuse.
In China and India it is still held in great esteem for the relief
of rheumatic and syphilitic complaints, and as an aphrodisiac and
demulcent. Polak asserts that the tubers of _Smilax_ are consumed as
food by Turcomans and Mongols.[2658]

=Substitutes=—Several American species of _Smilax_ furnish a nearly
allied drug, which at various times has been brought into commerce as
_Radix Chinæ occidentalis_. It was already known to the authors of the
16th century; we met with it in 1872, and before, in the London market,
as an importation from Puntas Arenas, the port of Costa Rica on the
Pacific coast.

Of the exact species it is difficult to speak with certainty: but
_S. Pseudo-China_ L. and _S. tamnoides_ L. growing in the United
States from New Jersey southwards; _S. Balbisiana_ Knth., a plant
common in all the West Indian Islands; and _S. Japicanga_ Griseb.,
_S. syringoides_ Griseb. and _S. Brasiliensis_ Spreng., are reputed
to afford large tuberous rhizomes which in their several localities
replace the China root of Asia, and are employed in a similar
manner.[2659]

[2657] _Returns of Trade at the Treaty Ports in China for 1872_, pp.
34, 154, and the same for 1874.

[2658] See p. 324, note 2.—We quote this statement with reserve,
knowing that both Chinese and Europeans sometimes confound China
root with the singular fungoid production termed _Pachyma Cocos_.
The first is called in Chinese _Tu-fuh-ling_,—the second _Fuh-ling_
or _Pe-fuh-ling_.—See Hanbury, _Pharm. Journ._ iii. (1862) 421; and
_Science Papers_, 202. 267.—F. Porter Smith, _Mat. Med. and Nat.
Hist. of China_, 1871. 198; Dragendorff, _Volksmedicin Turkestans_ in
Buchner’s _Repertorium_, xxii. (1873) 135.

[2659] De Candolle’s monograph, quoted at p. 705, note 4, may be
consulted on the above species.




GRAMINEÆ.


SACCHARUM.

_Sugar_, _Cane-Sugar_, _Sucrose_; F. _Sucre_, _Sucre de canne_; G.
_Zucker_, _Rohrzucker_.

=Botanical Origin=—_Saccharum officinarum_ L., the Sugar Cane. The
jointed stem is from 6 to 12 feet high, solid, hard, dense, internally
juicy, and hollow only in the flowering tops. Several varieties are
cultivated, as the _Country Cane_, the original form of the species;
the _Ribbon Cane_, with purple or yellow stripes along the stem; the
_Bourbon_ or _Tahiti Cane_, a more elongated, stronger, more hairy and
very productive variety. _Saccharum violaceum_ Tussac, the _Batavian
Cane_, is also considered to be a variety; but the large _S. chinense_
Roxb. introduced from Canton in 1796 into the Botanic Gardens of
Calcutta, may be a distinct species; it has a long, slender, erect
panicle, while that of _S. officinarum_ is hairy and spreading, with
the ramifications alternate and more compound, not to mention other
differences in the leaves and flowers.

The sugar cane is cultivated from cuttings, the small seeds very seldom
ripening. It succeeds in almost all tropical and subtropical countries,
reaching in South America and Mexico an elevation above the sea of
5000-6000 feet. It is cultivated in most parts of India and China up to
30-31° N. lat, the mountainous regions excepted.

From the elaborate investigations of Ritter,[2660] it appears that
_Saccharum officinarum_ was originally a native of Bengal, and of the
Indo-Chinese countries, as well as of Borneo, Java, Bali, Celebes, and
other islands of the Malay Archipelago. But there is no evidence that
it is now found any where in a wild state.

=History=[2661]—The sugar cane was doubtless known in India from time
immemorial, and grown for food as it still is at the present day,
chiefly in those regions which are unsuited for the manufacture of
sugar.[2662]

Herodotus, Theophrastus, Seneca, Strabo, and other early writers had
some knowledge of raw sugar, which they speak of as the _Honey of
Canes_ or _Honey made by human hands_, not that of bees; but it was
not until the commencement of the Christian era, that the ancients
manifested an undoubted acquaintance with sugar, under the name of
_Saccharon_.

Thus Dioscorides[2663] about A.D. 77 mentions the concreted honey
called Σάκχαρον found upon canes (ὲπὶ τῶν καλάμων) in India and Arabia
Felix, and which in substance and brittleness resemble salt. Pliny
evidently knew the same thing under the name _Saccharum_; and the
author of the Periplus of the Erythrean Sea, A.D. 54-68, states that
honey from canes, called σάκχαρι, is exported from Barygaza, in the
Gulf of Cambay, to the ports of the Red Sea, west of the _Promontorium
Aromatum_, that is to say to the coast opposite Aden. Whether at that
period sugar was produced in Western India, or was brought thither from
the Ganges, is a point still doubtful.

[2660] _Erdkunde von Asien_, ix. West-Asien, Berlin, 1840. pp. 230-291.

[2661] The learned investigations of Heyd, _Levantehandel_, ii. (1879)
665-667, afford exhaustive information about the medicinal history of
sugar.

[2662] The production which the English translators of the Bible have
rendered _Sweet Cane_, and which is alluded to by the prophets Isaiah
(ch. xliii. 24) and Jeremiah (ch. vi. 20) as a commodity imported
from a distant country, has been the subject of much discussion. Some
have supposed it to be the sugar cane; others, an aromatic grass
(_Andropogon_). In our opinion, there is more reason to conclude that
it was _Cassia Bark_.

[2663] Lib. ii. c. 104.

Bengal is probably the country of the earliest manufacture of sugar;
hence its names in all the languages of Western-Asiatic and European
nations are derived from the Sanskrit _Sharkarā_, signifying a
substance in the shape of small grains or stones. It is strange that
this word contains no allusion to the _taste_ of the substance.

_Candy_, as sugar in large crystals is called, is derived from the
Arabic _Kand_ or _Kandat_, a name of the same signification. An old
Sanskrit name of Central Bengal is _Gura_, whence is derived the word
_Gula_, meaning _raw sugar_, a term for sugar universally employed
in the Malayan Archipelago, where on the other hand they have their
own names for the sugar cane, although not for sugar. This fact again
speaks in favour of Ritter’s opinion, that the preparation of sugar
in a dry crystalline state is due to the inhabitants of Bengal. Sugar
under the name of _Shi-mi_, i.e. _Stone-honey_, is frequently mentioned
in the ancient Chinese annals among the productions of India and
Persia; and it is recorded that the Emperor Tai-tsung, A.D. 627-650,
sent an envoy to the kingdom of Magadha in India, the modern Bahar, to
learn the method of manufacturing sugar.[2664] The Chinese, in fact,
acknowledge that the Indians between A.D. 766 and 780 were their first
teachers in the art of refining sugar, for which they had no particular
ancient written character.

An Arabian writer, Abu Zayd al Hasan,[2665] informs us that about
A.D. 850 the sugar cane was growing on the north-eastern shore of
the Persian Gulf; and in the following century, the traveller Ali
Istakhri[2666] found sugar abundantly produced in the Persian province
of Kuzistan, the ancient Susiana. About the same time (A.D. 950), Moses
of Chorene, an Armenian, also stated that the manufacture of sugar was
flourishing near the celebrated school of medicine at Jondisabur in the
same province, and remains of this industry in the shape of millstones,
&c., still exist near Ahwas.

Persian physicians of the 10th and 11th centuries, as Rhazes, Haly
Abbas, and Avicenna, introduced sugar into medicine. The Arabs
cultivated the sugar cane in many of their Mediterranean settlements,
as Cyprus, Sicily, Italy, Northern Africa, and Spain. The Calendar of
Cordova[2667] shows that as early as A.D. 961 the cultivation was well
understood in Spain, which is now the only country in Europe where
sugar mills still exist.[2668]

William II., King of Sicily, presented in A.D. 1176 to the convent of
Monreale mills for grinding cane, the culture of which still lingers at
Avola near Syracuse, though only for the sake of making rum. In 1767,
the sugar plantations and sugar houses at this spot were described by a
traveller[2669] as “worth seeing.”

During the middle ages England, in common with the rest of Northern
Europe, was supplied with sugar from the Mediterranean countries,
especially Egypt and Cyprus. It was imported from Alexandria as early
as the end of the 10th century by the Venetians, with whom it long
remained an important article of trade. Thus we find[2670] that in
A.D. 1319, a merchant in Venice, Tommaso Loredano, shipped to London
100,000 lb. of sugar, the proceeds of which were to be returned in
_wool_, which at that period constituted the great wealth of England.
Sugar was then very dear: thus from 1259 to 1350, the average price
in England was about 1_s._ per lb., and from 1351 to 1400, 1_s._
7_d._[2671] In France during the same period it must have been largely
obtainable, though doubtless expensive. King John II. ordered in 1353
that the apothecaries of Paris should not use honey in making those
confections which ought to be prepared with the good white sugar called
_cafetin_,[2672] a name alluding to the peculiar shape of the loaf
which was not uncommon at that time.[2673]

[2664] Bretschneider, _Chinese Botanical Works_, 1870. 46.

[2665] Ritter, _l.c._ 286.

[2666] P. 57 of the book quoted in the Appendix.

[2667] _Le Calendrier de Cordoue de l’année_ 961, par R. Dozy, Leyde,
1873. 25. 41. 91.

[2668] There are several in the neighbourhood of Malaga.

[2669] Riedesel, _Travels through Sicily_, Lond. 1773. 67.

[2670] Marin, _Commercio de’ Veneziani_, v. 306.

[2671] Rogers, _Hist. of Agriculture and Prices in England_, i. (1866)
633. 641.

[2672] _Ordonnances des rois de France_, ii. (1729) 535.

[2673] Several other varieties of sugar occurring in the mediæval
literature are explained in the _Documente_ (quoted at page 404,
footnote 7) p. 32.

The importance of the sugar manufacture in the East was witnessed in
the latter half of the 13th century by Marco Polo;[2674] and in 1510
by Barbosa and other European travellers; and the trading nations
of Europe rapidly spread the cultivation of the cane over all the
countries, of which the climate was suitable. Thus its introduction
into Madeira goes back as far as A.D. 1420; it reached St. Domingo in
1494,[2675] the Canary Islands in 1503, Brazil in the beginning of
the 16th century, Mexico about 1520, Guiana about 1600, Guadaloupe in
1644, Martinique in 1650,[2676] Mauritius towards 1750, Natal[2677] and
New South Wales, about 1852,[2678] while from a very early period the
sugar cane had been propagated from the Indian Archipelago over all the
islands of the Pacific Ocean.

The ancient cultivation in Egypt, probably never quite extinct, has
been revived on an extensive scale by the Khedive Ismail Pasha. There
were 13 sugar factories, making raw sugar, belonging to the Egyptian
Government at work in 1872, and about 100,000 acres of land devoted to
sugar cane. The export of sugar from Egypt in 1872 reached 2 millions
of _kantars_, or about 89,200 tons.[2679]

The imperfection of organic chemistry previous to the middle of the
18th century, permitted no exact investigations into the chemical
nature of sugar. Marggraf of Berlin[2680] proved in 1747 that sugar
occurs in many vegetables, and succeeded in obtaining it in a pure
crystallized state from the juice of beet root. The enormous practical
importance of this discovery did not escape him, and he caused serious
attempts to be made for rendering it available, which were so far
successful that the first manufactory of beet-sugar was established in
1796 by Achard at Kunern in Silesia.

This new branch of industry[2681] was greatly promoted by the
prohibitive measures, whereby Napoleon excluded colonial sugar from
almost the whole Continent; and it is now carried forward on such a
scale that 640,000 to 680,000 tons of beet root sugar are annually
produced in Europe, the entire production of cane-sugar being estimated
at 1,260,000 to 1,413,000 tons.[2682]

Among the British colonies, Mauritius,[2683] British Guiana,[2684]
Trinidad,[2685] Barbados,[2686] and Jamaica,[2687] produce at present
the largest quantity of sugar.

[2674] Yule, _Book of Ser Marco Polo_, ii. (1871) 79. 171. 180. &c.

[2675] _Letters of Christ._ _Columbus_ (Hakluyt Society) 1870. 81-84.

[2676] De Candolle, _Géogr. botanique_, 836.

[2677] The value of the sugar exported from Natal in 1871 reached the
astonishing amount of £180,496 and £135,201 in 1876.

[2678] Yet owing to the gold discoveries, the propagation of the cane
in Australia was little thought of until about 1866 or 1867, when small
lots of sugar were made.

[2679] Consul Rogers, _Report on the Trade of Cairo for 1872_,
presented to Parliament.

[2680] _Expériences chymiques faites dans le dessein de tirer un
véritable sucre de diverses plantes qui croissent dans nos contrées_,
par Mr. Marggraf, traduit du latin—_Hist. de l’Académie royale des
sciences et belles-lettres_, année 1747 (Berlin 1749) 79-90.

[2681] And also that of _milk sugar_, which was then much used on the
Continent to _adulterate_ cane-sugar.

[2682] _Produce Markets Review_, March 28, 1868.

[2683] 2,255,249 quintals (one quintal = 108 lb. avdp.) in 1876.

[2684] 120,030 hhds (one hogshead = 1,792 lb.) in 1876.

[2685] 114,968,384 lb. in 1876.

[2686] 38,013 hhds. in 1876.

[2687] 29,074 hhds. in 1876.

=Production=—No crystals are found in the parenchyme of the cane, the
sugar existing as an aqueous solution, chiefly within the cells of
the centre of the stem. The transverse section of the cane exhibits
numerous fibro-vascular bundles, scattered through the tissue, as in
other monocotyledonous stems; yet these bundles are most abundant
towards the exterior, where they form a dense ring covered with a
thin epidermis, which is very hard by reason of the silica which is
deposited in it.[2688] In the centre of the stem the vascular bundles
are few in number; the parenchyme is far more abundant, and contains
in its thin-walled cells an almost clear solution of sugar, with a few
small starch granules and a little soluble albuminous matter. This last
is met with in larger quantity in the cambial portion of the vascular
bundles. Pectic principles are combined with the walls of the medullary
cells, which however do not swell much in water (Wiesner).

From these glances at the microscopical structure of the cane, the
process to be followed for obtaining the largest possible quantity
of sugar becomes evident. This would consist in simply macerating
thin slices of the cane in water, which would at once penetrate the
parenchyme loaded with sugar, without much attacking the fibro-vascular
bundles containing more of albuminous than of saccharine matter.
By this method, the epidermal layer of the cane would not become
saturated with sugar, nor would it impede its extraction,—results which
necessarily follow when the cane is crushed and pressed.[2689]

The process hitherto generally practised in the colonies,—that of
extracting the juice of the cane by crushing and pressing,—has been
elaborately described and criticised by Dr. Icery of Mauritius.[2690]
In that island, the cane, six varieties of which are cultivated, is
when mature composed of _Cellulose_, 8 to 12 per cent.; _Sugar_, 18
to 21; _Water_, including albuminous matter and salts, 67 to 73. Of
the entire quantity of juice in the cane, from 70 to 84 per cent. is
extracted for evaporation, and yields in a crystalline state about
three-fifths of the sugar which the cane originally contained. This
juice, called in French _vesou_, has on an average the following
composition:—

    Albuminous matters                     0·03
    Granular matter (starch?)              0·10
    Mucilage containing nitrogen           0·22
    Salts, mostly of organic acids[2691]   0·29
    Sugar                                 18·36
    Water                                 81·00
                                         ------
                                         100·00

[2688] Stems of American sugar cane, dried at 100° C., yielded 4
per cent of ash, nearly half of which was silica.—Popp, in Wiggers’
_Jahresbericht_, 1870. 35.

[2689] The plan of obtaining a syrup by macerating the sliced fresh
cane, has been tried in Guadaloupe, but abandoned owing to some
practical difficulties in exhausting the cane and in carrying on the
evaporation of the liquors with sufficient rapidity. Experiments for
extracting a pure syrup by means of cold water from the _sliced and
dried_ cane, seem to promise good results.—See a paper by Dr. H. S.
Mitchell in _Journ. of Soc. of Arts_, Oct. 23, 1868.

[2690] _Annales de Chimie et de Physique_, v. (1865) 350-410.—See
also, for Cuba, Alvaro Reynoso _Ensayo sobre el cultivo de la caña
de Azúcar_, Madrid, 1865. 359.—For British Guiana, _Catal. of
Contributions from Brit. Guiana to Paris Exhib._ 1867. pp. xxxviii.-xli.

[2691] _Aconitic Acid_ (p. 11) has been met with by Behr (1877) in West
Indian molasses.

There is also present in the juice a very small amount of a slightly
aromatic substance (essential oil?) to which the _crude_ cane sugar
owes a peculiar odour which is not observed in sugar from other
sources. The first two classes of the above enumerated substances
render the juice turbid, and greatly promote its fermentation, but they
easily separate by boiling, and the juice may then be kept a short time
without undergoing change. In many colonies the yield is said to be far
inferior to what it should be; yet the juice is obtained in a state
allowing of easier purification, when its extraction is not carried to
the furthest limit.

In beet root as well as in the sugar cane, cane-sugar only was
said to be present; Icery however has proved that in the cane some
uncrystallizable (inverted) sugar is always present. Its quantity
varies much, according to the places where the cane grows, and its age.
The tops of quick-growing young canes yielded a _vesou_ containing
2·4 per cent. of uncrystallizable sugar; 3·6 of cane sugar; and 94
of water. Moist and shady situations greatly promote the formation
of the former kind of sugar, which also prevails in the tops,
chiefly when immature. Hence that observer concludes that at first
the uncrystallizable variety of sugar is formed, and subsequently
transformed into cane-sugar by the force of vegetation, and especially
by the influence of light. Perfectly ripened canes contain only ¹/₇₅ to
¹/₅₀ of all their sugar in the uncrystallizable state.

=Description and Chemical Composition=—Cane-sugar is the type of
a numerous class of well-defined organic compounds, of frequent
occurrence throughout the vegetable and animal kingdoms, or
artificially obtained by decomposing certain other substances; in the
latter case, however, glucose or some other sugar than cane-sugar is
obtained. cane-sugar, C₁₂H₂₂O₁₁, or C₁₂H₁₄(OH)₈O₃, melts, without
change of composition, at 160° C., several other kinds of sugar giving
off water, with which they form crystallized compounds at the ordinary
temperature.

Cane-sugar forms hard crystals of the oblique rhombic system, having
a sp. gr. of 1·59. Two parts are dissolved at 15° C. by one part of
water,[2692] and by much less at an elevated temperature; a slight
depression of the thermometer is observable in the former case. One
part of sugar dissolved in one of water, forms a liquid of sp. gr.
1·23; two of sugar in one of water, a liquid of sp. gr. 1·33. Sugar
requires 65 parts of spirit of wine (sp. gr. 0·84) or 80 parts of
anhydrous alcohol for solution; ether does not act upon it.

[2692] It is commonly stated that _three_ parts can be dissolved in one
of cold water; but this is not the fact.

A ray of polarized light is deviated by an aqueous solution of cane
sugar to the _right_, but by some other kinds of sugar to the _left_,
as first shown by Biot. These optical powers are highly important, both
in the practical estimation of solutions of sugar, and in scientific
studies connected with sugar or saccharogenous substances. The
optical as well as chemical properties of sugar are altered by many
circumstances, as the action of dilute acids or alkalis, or by the
influence of minute fungi. Yeast occasions sugar to undergo alcoholic
fermentation. Other ferments set up an action by which butyric, lactic
or propionic acid are produced.

Cane-sugar is of a purer and sweeter taste than most other sugars.
Though it does not alter litmus paper, yet with alkalis it forms
compounds some of which are crystallizable. From an alkaline solution
of tartrate of copper, cane-sugar throws down no protoxide, unless
after boiling.

If sugar is kept a short time in a state of fusion at 160° C., it is
converted into one molecule of _Grape Sugar_ and one of _Levulosan_;
the former can be either isolated by crystallization or destroyed
by fermentation, the latter being incapable of crystallizing or of
undergoing fermentation.

Cane-sugar which has been melted at 160° C. is deliquescent and readily
soluble in anhydrous alcohol, and its rotatory power is diminished or
entirely destroyed. It is no longer crystallizable, and its fusing
point has become reduced to about 93° C. Yet before undergoing these
evident alterations, it assumes an amorphous condition if allowed to
melt with a third of its weight of water, becoming always a little
coloured by pyrogenous products. In the course of time, however, this
amorphous sugar loses its transparency and reassumes the crystalline
form. Like sulphur and arsenious acid, it is capable of existing either
in a crystallized or an amorphous state.

If sugar is heated to about 190° C. water is evolved, and we obtain
the dark brown products commonly called _Caramel_ or _Burnt Sugar_.
They are of a peculiar sharp flavour, of a bitter taste, incapable
of fermenting and deliquescent. One of the constituents of caramel,
_Caramelane_, C₁₂H₁₈O₉, has been obtained by Gélis (1862) perfectly
colourless. When the heat is augmented, the sugar at last suffers a
decomposition resembling that which produces tar (see p. 621), its
pyrogenous products being the same or very analogous to those of the
dry distillation of wood.

=Varieties of Cane-sugar=—The experiments of Marggraf referred to at
p. 717, note 9, showed that cane-sugar is by no means confined to the
sugar cane; and it is in fact extracted on an extensive scale from
several other plants, of which the following deserve mention:—

_Beet Root_—The manufacture of cane-sugar from the fleshy root of a
cultivated variety of _Beta maritima_ L., is now largely carried on in
Continental Europe and in America, and with admirable results.

Of fresh beet root, 100 parts contain on an average 80 per cent. of
water, 11 to 13 of cane-sugar, and about 7 per cent. of pectic and
albuminous matters, cellulose and salts. Of the total amount of juice
which the root contains, eight-ninths are extracted; and by the best
process now in practice, 8 to 9 parts of sugar from every 100 parts of
fresh root. The yield of crystalline sugar is still on the increase,
owing to continual improvements in the mechanical and chemical parts of
the process.

_Palm_—Several species are of great utility for the production of the
sugar called by Europeans _Jaggery_.[2693] This substance is obtained
by the natives of India in the following manner:—The young growing
spadix, or flowering shoot, of the palm is cut off near its apex; and
an earthen vessel is tied on to the stump to receive the juice that
flows out. This vessel is emptied daily; while to promote a continuous
flow of sap, a thin slice is cut from the wounded end. The juice thus
collected, if at once boiled down, yields the crude brown sugar known
as _jaggery_. If allowed to ferment, it becomes the inebriating drink
called _Toddy_ or palm wine; or it may be converted into vinegar. The
spirit distilled from toddy is _Arrack_.

[2693] A word of Sanskrit origin, corrupted from the Canarese
_sharkari_.

Of the sugar-yielding palms of Asia, _Phœnix silvestris_ Roxb., which
is supposed to be the wild form of the date palm, is one of the more
important. The coco-nut palm, _Cocos nucifera_ L.; the magnificent
Palmyra palm, _Borassua flabelliformis_ L.; and the Bastard Sago,
_Caryota urens_ L., also furnish important quantities of sugar. In
the Indian Archipelago, sugar is obtained from the sap of _Arenga
saccharifera_ Mart., which grows there in abundance as well as in
the Philippines and the Indo-Chinese countries. It is also got from
_Nipa fruticans_ Thunb., a tree of the low coast regions, extensively
cultivated in Tavoy.

De Vry[2694] has advocated the manufacture of sugar from the palm as
the most philosophical, seeing that its juice is a nearly pure aqueous
solution of sugar: that as no mineral constituents are removed from the
soil in this juice, the costly manuring, as well as the laborious and
destructive processes required to eliminate the juice from such plants
as the sugar cane and beet root, are avoided. And finally, that palms
are perennial, and can many of them be cultivated on a soil unsuitable
for any cereal.

_Maple_—In America, considerable quantities of sugar identical with
that of the cane are obtained in the woods of the Northern United
States and of Canada, by evaporating the juice of maples. The species
chiefly employed are _Acer saccharinum_ Wangenh., the Common Sugar
Maple, and its variety (var. _nigrum_) the Black Sugar Maple. _A.
Pennsylvanicum_ L., _A. Negundo_ L. (_Negundo aceroides_ Moench.) and
_A. dasycarpum_ Ehrh. are also used; the sap of the last is said to be
the least saccharine.

As the juice of these trees yields not more than about 2 per cent. of
sugar, it requires for its solidification a large expenditure of fuel.
The manufacture of maple sugar can therefore be advantageously carried
on only in countries remote from markets whence ordinary sugar can be
procured, or in regions where fuel is extremely plentiful. In North
America it flourishes only between 40° and 43° N. lat. We are not aware
of any estimate of the total production of maple sugar. The Census of
Pennsylvania of 1870 gave the following figures as referring to its
manufacture in that State:—

       1850             1860             1870
    2,326,525 lb.    2,768,965 lb.    1,545,917 lb.[2695]

_Sorghum_—Another plant of the same order as _Saccharum_ is _Sorghum
saccharatum_ Pers. (_Holcus saccharatus_ L.) a native of Northern
China,[2696] which has of late been much tried as a sugar-yielding
plant both in Europe and North America; yet without any great success,
as the purification of the sugar is accomplished with peculiar
difficulty. As in the sugar cane, there are in sorghum crystallizable
and uncrystallizable sugars, the former being at its maximum amount
when the grain reaches maturity. The importance of the plant however is
rapidly increasing on account of the value of its leaves and grain as
food for horses and cattle, and of its stems which can be employed in
the manufacture of paper and of alcohol.

[2694] _Journ. de Pharm._ i. (1865) 270.

[2695] Consul Kortright, in _Consular Reports_ presented to Parliament,
July 1872, p. 988.

[2696] Introduced into Europe in 1850, by M. de Montigny, French Consul
at Shanghai.—Sicard, _Monographie de la Canne à sucre de la Chine,
dite_ Sorgho à sucre, Marseille, 1856; Joulie, _Journ. de Pharm._ i.
(1865) 188.

=Commerce=—The value of the sugar imported into the United Kingdom is
constantly increasing, as shown by the following figures:—

                       1868           1870            1872
    _Unrefined_    £13,339,758    £14,440,502     £18,044,898
    _Refined_       £1,156,188     £2,744,366      £3,142,703

The quantity of _Unrefined Sugar_ imported in 1872 was 13,776,696 cwt.,
of which about 3,000,000 cwt. were furnished by the Spanish West India
Islands, 2,700,000 cwt. by the British West India Islands, 1,800,000
cwt. by Brazil, 1,100,000 cwt. by France, and 960,000 cwt. by Mauritius.

Of _Refined Sugar_ the imports from France and Belgium into the United
Kingdom were—

      1874           1875        1876
    133,800        102,300      92,044 tons.

=Uses=—Refined sugar is employed in pharmacy for making syrups,
electuaries and lozenges, and is useful not merely for the sake of
covering the unpleasant taste of other drugs, but also on account of a
preservative influence which it exerts over their active constituents.

Muscovado or Raw Sugar is not used in medicine. The dark
uncrystallizable syrup, known in England as _Molasses_, _Golden Syrup_,
and _Treacle_,[2697] and in foreign pharmacy as _Syrupus Hollandicus
vel communis_, which is formed in the preparation of pure sugar by the
influence of heat, alkaline bodies, microscopic vegetation, and the
oxygen of the air, is sometimes employed for making pill masses. The
treacle of colonial sugar alone is adapted for this purpose, that of
beet root having a disagreeable taste, and containing from 19 to 21 per
cent. of oxalate, tartrate and malate of potassium, and only 56 to 64
of sugar.[2698] The treacle of colonial sugar usually contains 5 to 7
per cent. of salts.

[2697] How the word _Treacle_ came to be transferred from its
application to an opiate medicine to become a name for _molasses_, we
know not. In the description of sugar-making given by Salmon in his
_English Physician or Druggist’s Shop opened_, Lond. 1663, treacle is
never mentioned, but only “_melussas_.”

[2698] Landolt, Zeitschr. _für analyt. Chem._ vii. (1868) 1-29.


HORDEUM DECORTICATUM.

_Hordeum perlatum_, _Fructus vel Semen Hordei_; _Pearl Barley_; F.
_Orge mondé ou perlé_; G. _Gerollte Gerste_, _Gerstegraupen_.

=Botanical Origin=—_Hordeum distichum_ L.,—the Common or Long-eared
Barley is probably indigenous to western temperate Asia, but has been
cultivated for ages throughout the northern hemisphere. In Sweden its
cultivation extends as far as 68° 38’ N. lat.; on the Norwegian coast
up to the Altenfjord in 70° N. lat.; even in Lapland, it succeeds as
high as 900 to 1350 feet above the level of the sea. In several of
the southern Swiss Alpine valleys, barley ripens at 5000 feet, and
in the Himalaya at 11,000 feet. In the Equatorial Andes, where it is
extensively grown, it thrives up to at least 11,000 feet above the sea.
No other cereal can be cultivated under so great a variety of climate.

According to Bretschneider,[2699] barley is included among the five
cereals which it is related in Chinese history were sowed by the
Emperor Shen-nung, who reigned about 2700 B.C.; but it is not one of
the five sorts of grain which are used at the ceremony of ploughing and
sowing as now annually performed by the emperors of China.

Theophrastus was acquainted with several sorts of barley (Κριθή), and
among them, with the six-rowed kind or _hexastichon_, which is the
species that is represented on the coins struck at Metapontum[2700] in
Lucania, between the 6th and 2nd centuries B.C.

[2699] _On Chinese Botanical Works_, etc., Foochow, 1870. 7. 8.

[2700] Metapontum lay in the plain between the rivers Bradano and
Basento in the gulf of Taranto.

Strabo and Dioscorides in the 1st century allude to drinks made from
barley, which according to Tacitus were even then familiar to the
German tribes, as they are known to have been still earlier to the
Greeks and Egyptians.

Barley is mentioned in the Bible as a plant of cultivation in Egypt
and Syria, and must have been, among the ancient Hebrews, an important
article of food, judging from the quantity allowed by Solomon to the
servants of Hiram, king of Tyre (B.C. 1015). The tribute of barley paid
to King Jotham by the Ammonites (B.C. 741) is also exactly recorded.
The ancients were frequently in the practice of removing the hard
integuments of barley by roasting it, and using the torrefied grain as
food.

=Manufacture=—For use in medicine and as food for the sick, barley
is not employed in its crude state, but only when deprived more or
less completely of its husk. The process by which this is effected
is carried on in mills constructed for the purpose, and consists
essentially in passing the grain between horizontal millstones, placed
so far apart as to rub off its integuments without crushing it.
Barley partially deprived of its husk is known as _Scotch_, _hulled_
or _Pot Barley_. When by longer and closer grinding the whole of the
integuments have been removed, and the grain has become completely
rounded, it is termed _Pearl Barley_. In the _British Pharmacopœia_ it
is this sort alone which is ordered to be used.

=Description=—Pearl Barley is in subspherical or somewhat ovoid grains
about 2 lines in diameter, of white farinaceous aspect, often partly
yellowish from remains of the adhering husk, which is present on the
surface, as well as in the deep longitudinal furrow with which each
grain is indented. It has the farinaceous taste and odour which are
common to most of the cereal grains.

=Microscopic Structure=—The albumen which constitutes the main portion
of the grain is composed of large thin-walled parenchyme, the cells of
which on transverse section are seen to radiate from the furrow, and
to be lengthened in that direction rather than longitudinally. In the
vicinity of the furrow alone the tissue of the albumen is narrower. Its
predominating large cells show a polygonal or oval outline, whilst the
outer layer is built up of two, three or four rows of thick-walled,
coherent, nearly cubic gluten-cells. This layer, about 70 mkm. thick,
is coated with an extremely thin brown tegument, to which succeeds a
layer about 30 mkm. thick, of densely packed, tabular, greyish or
yellowish cells of very small size; this proper coat of the fruit in
the furrow is of rather spongy appearance.

In some varieties of barley the fruit is constituted of the above
tissues alone and the shell, but in most the paleæ are likewise
present. They consist chiefly of long fibrous, thick-walled cells,
two or four rows deep, constituting a very hard layer. On tranverse
section, this layer forms a coherent envelope about 35 mkm. thick; its
cells when examined in longitudinal section show but a small lumen of
peculiar undulated outline from secondary deposits.

The gluten-cells varying considerably in the different cereal grains,
afford characters enough to distinguish them with certainty. In wheat,
for instance, the gluten-cells are in a single row, in rice they form a
double or single row, but its cells are transversely lengthened.

The inner tissue of the albumen in barley is filled up with large
irregularly lenticular, and with extremely small globular starch
granules, the first being 20 to 35 mkm., the latter 1, 2 to 3 mkm.
in diameter, with no considerable number of intermediate size.
The concentric layers constituting the large granules may be made
conspicuous by moistening with chromic acid.

The layer alluded to as being composed of _gluten-cells_ is loaded
with extremely small granules of albuminous matters (gluten), which
on addition of iodine are coloured intensely yellow. These granules,
which, considering barley as an article of food, are of prominent
value, are not confined to the gluten-cells, but the neighbouring
starch-cells also contain a small amount of them: and in the narrow
zone of denser tissue projecting from the furrow into the albumen,
protein principles are equally deposited, as shown by the yellow
coloration which iodine produces.

The gluten-cells, the _membrane embroynnaire_ of Mège-Mouriès, contain
also, according to the researches on bread[2701] made by this chemist
(1856), _Cerealin_, an albuminous principle soluble in water, which
causes the transformation of starch into dextrin, sugar, and lactic
acid. In the husks (_épiderme_, _épicarpe_ and _endocarpe_) of wheat,
Mège-Mouriès found some volatile oil and a yellow extractive matter,
to which, together with the cerealin, is due the acidity of bread made
with the flour containing the bran.

=Chemical Composition=—Barley has been submitted to careful analyses
by many chemists, more especially by Lermer.[2702] The grains contain
usually 13 to 15 per cent. of water; after drying, they yield to ether
3 per cent. of fat oil, with insignificant proportions of tannic and
bitter principles, residing chiefly in the husks. Lermer further found
in the whole grains, 63 per cent. of starch, 7 of cellulose, 6·6 of
dextrin, 2·5 of nitrogen, a small amount of lactic acid, and 2·4 of ash.

[2701] He actually examined _wheat_, not barley; we assume the chemical
constitution of the two grains to be similar.

[2702] Wittstein, _Vierteljahresschr. für prakt. Pharm._ xii. (1863)
4-23.

The analysis of Poggiale (1856) gave nearly the same composition,
namely, water 15, oil 2·4, starch 60, cellulose 8·8, albuminous
principles 10·7, ash 2·6.

The protein, or albuminous matter consists of different principles,
chiefly insoluble in cold water. The soluble portion is partly
coagulated on boiling, partly retained in solution: 2·5 per cent. of
nitrogen, as above, would answer to about 16 per cent. of albuminous
matters. Their soluble part seems to be deposited in the starch-cells,
next to the gluten-cells, which latter contain the insoluble portion.

The ash, according to Lermer, contains 29 per cent. of silicic acid,
32·6 of phosphoric acid, 22·7 of potash, and only 3·7 of lime. In
the opinion of Salm-Horstmar, fluorine and lithia are indispensable
constituents of barley.

The fixed oil of barley, as proved in 1863 by Hanamann, is a compound
of glycerin with either a mixture of palmitic and lauric acids, or
less probably with a peculiar fatty acid. Beckmann’s _Hordeinic Acid_
obtained in 1855 by distilling barley with sulphuric acid, is probably
lauric acid. Lintner (1868) has shown barley to contain also a little
_Cholesterin_ (p. 420).

Lastly, Kühnemann (1875) extracted from barley a crystallized
dextrogyrate sugar, and (1876) an amorphous lævogyrate mucilaginous
substance _Sinistrin_ (see p. 692); according to that chemist, dextrin
is altogether wanting in barley.

Barley when malted loses 7 per cent.; it then contains 10 to 12 per
cent. of sugar, produced at the expense of the starch; before malting,
no sugar is to be found.

=Uses=—Barley as a medicine is unimportant. A decoction is sometimes
prescribed as a demulcent or as a diluent of active remedies. An
aqueous extract of malt has been employed.


OLEUM ANDROPOGONIS.

_Oleum Graminis Indici_; _Indian Grass Oil_.

=Botanical Origin=—Among the numerous species of _Andropogon_[2703]
which have foliage abounding in essential oil, the following furnish
the fragrant _Grass Oils_ of commerce:—

1. _Andropogon Nardus_ L.,[2704]—a noble-looking plant, rising when in
flower to a height of 6 or more feet, extensively cultivated in Ceylon
and Singapore for the production of _Citronella Oil_.

2. _A. citratus_ D.C.,[2705] Lemon Grass,—a large coarse glaucous
grass, known only in a cultivated state, and very rarely producing
flowers. It is grown in Ceylon and Singapore for the sake of its
essential oil, which is called _Lemon Grass Oil_, _Oil of Verbena_
or _Indian Melissa Oil_; it is also commonly met with in gardens
throughout India and is not unfrequent in English hothouses. In Java it
is called _Sireh_.

3. _A. Schœnanthus_ L.,[2706] a grass of Northern and Central India,
having leaves rounded or slightly cordate at the base, yielding by
distillation the oil known as _Rúsa Oil_, _Oil of Ginger Grass_ or _of
Geranium_.

[2703] Major-General Munro has at our request investigated the
botanical characters of the fragrant species of _Andropogon_, and
examined a numerous suite of specimens in our possession. The synonyms
in foot-notes are given upon his authority.

[2704] _A. Martini_ Thwaites, _Enum. Plantarum Zeylaniæ_ nec
aliorum.—Fig. in Bentley and Trimen’s _Med. Plants_, part 28 (1878).

[2705] _A. citratum_ A.P. De Candolle, _Catalogus Plantarum Horti
Botanici Monspeliensis_, 1813; _A. Schœnanthus_ Wallich, _Plant. Asiat.
rariores_, iii. (1832) tab. 280; Roxburgh, _Flora Indica_, i. (1820)
278, quoad observationes, sed non quoad diagnosis.

[2706] Ventenat, _Jardin de Cels_, 1803. tab. 89; _A. Martini_ Roxb.
_Flor. Ind._ i. (1820) 280; _A. pachnodes_ Trinius, _Species Graminum_,
iii. (1836) tab. 327; _A. Calamus aromaticus_ Royle, _Illustrations of
Bot. of Himalayan Mountains_, 1839. tab. 97.

=History=—The aromatic properties of certain species of _Andropogon_
were well known to Rheede, Rumphius, and other early writers on Indian
natural history; and an oil distilled from the _Sireh_ grass in Amboyna
was known as a curiosity as early as 1717.[2707]

But it is only in very recent times that the volatile oils of these
plants have become objects of commerce with Europe. Lemon grass oil
is mentioned by Roxburgh in 1820 as being distilled in the Moluccas;
and it was first imported into London about the year 1832. Citronella
oil is of much more recent introduction. Ginger grass oil, called in
Hindustani _Rúsa ka tel_, is stated by Waring[2708] to have been first
brought to notice by Dr. N. Maxwell in 1825.

=Production=—Citronella and Lemon grass are cultivated about Galle and
at Singapore, the same estate often producing both. The grasses are
distilled separately, the essential oils being regarded as entirely
distinct, and having different market values. In Ceylon they are cut
for distillation at any time of year, but mostly in December and
January.

On the Perseverance Estate at Gaylang, Singapore, belonging to Mr. John
Fisher, an area of 950 acres is cultivated with aromatic grasses and
other plants, for the production of essential oils. The manufacture
was tried on a small scale in 1865, and has been so successful that an
aggregate of 200 lb. of various essential oils is now produced _daily_.
These oils are stated to be Citronella, Lemon Grass, Patchouly, Nutmeg,
Mace, Pepper, and Oman (p. 302): and mint is now being cultivated.[2709]

Ginger grass oil is distilled in the collectorate of Khandesh in the
Bombay Presidency. That produced in the district of Namár in the valley
of the Nerbudda, is sometimes called _Grass Oil of Namar_. We have
no particulars of the distillation, which however must be carried on
extensively.

=Description=—The Indian grass oils are lighter than water, devoid
of rotatory power when examined by polarized light, and do not alter
litmus paper. They are all extremely fragrant, having an odour like
a mixture of lemon and rose. Lemon grass, which in colour is a deep
golden brown, has an odour resembling that of the sweet-scented verbena
of the gardens, _Lippia citriodora_ H.B.K. Ginger grass oil, the
colour of which varies from pale greenish yellow to yellowish-brown,
has the odour of _Pelargonium Radula_ Aiton. The colour of citronella
oil is a light greenish yellow. The manufacture of Winter of Ceylon,
and of Fisher of Singapore, have a reputation for excellence, and are
generally indicated by name in drug sale catalogues.

=Chemical Composition=—Stenhouse[2710] examined in 1844 oil of ginger
grass given to him by Christison as _Oil of Namur_ (or _Nimar_). The
sample was of deep yellow, and apparently old, for when mixed with
water and subjected to distillation, it left nearly one half its bulk
of a fluid resin, the oil which passed over being colourless. After
rectification from chloride of calcium, it was shown to consist of a
hydrocarbon mixed with a small proportion of an oxygenated oil. The
latter having been decomposed by sodium, and the oil again rectified,
a second analysis was made which proved it isomeric with oil of
turpentine.

[2707] _Ephemerides Naturæ Curiosorum_, cent. v.-vi. (1717), appendix
157.

[2708] _Pharmacopœia of India_, 1868. 465.

[2709] _Straits Settlements Blue Book for 1872_, Singapore, 1873. 465.

[2710] _Mem. of Chem. Soc._ ii. (1845) 122.

A genuine grass oil from Khandesh, derived as we suppose from the
same species, which was examined by one of us (F.), yielded nothing
crystalline when saturated with dry hydrochloric acid; but when the
liquid was afterwards treated with fuming nitric acid, crystals of the
compound, C₁₀H₁₆, HCl, sublimed into the upper part of the vessel. We
have observed that the oils both of lemon grass and citronella yield
solid compounds, if shaken with a saturated solution of bisulphite of
sodium.

Citronella oil was found by Gladstone (1872) to be composed chiefly of
an oxidized oil, which he called _Citronellol_, and which he separated
by fractional distillation into two portions, the one boiling at
202-205° C., the other 199-202° C. The composition of each portion is
indicated by the formula C₁₀H₁₆O.

Wright’s researches (1874) tend rather to show the prevailing part of
citronella oil to consist of the liquid C₁₀H₁₈O, boiling near 210°,
which he calls _Citronellol_. It unites with bromine, and the resulting
compound, upon heating, breaks up according to the following equation:—

    C₁₀H₁₈OBr₂ = OH₂ · 2 HBr · C₁₀H₁₄.
                              Cymene.

=Commerce=—The growing trade in grass oil is exemplified in a striking
manner by the following statistics. The export of _Citronella Oil_ from
Ceylon in 1864 was 622,000 ounces, valued at £8230. In the _Ceylon Blue
Book_, the exports for 1872 are returned thus:—

    To the United Kingdom          1,163,074 ounces}
      British India                    5,713   ”   } 1,595,257
      United States of North America 426,470   ”   }    ounces.[2711]

In 1875 the oil shipped from Ceylon to the United Kingdom was valued at
42,871 rupees, that sent to other foreign countries at 45,871 rupees,
to British possessions 660 rupees (one rupee equal to about 2_s._).

_Oil of Lemon Grass_, which is a more costly article and less
extensively produced, was exported from Ceylon during the same year
to the extent of 13,515 ounces, more than half of which quantity was
shipped to the United States. There are no analogous statistics for
these two oils from Singapore, where, as stated at p. 726, they are now
largely manufactured.

By the official _Report on the External Commerce of Bombay_, published
in 1867, we find that during the year ending 31 March, 1867, _Grass
Oil_ [i.e. _Ginger Grass_ or _Rúsa Oil_] was exported thence to the
amount of 41,643 lb. This oil is shipped to England and to the ports of
the Red Sea.

=Uses=—Grass oils are much esteemed in India as an external application
in rheumatism. Rúsa oil is said to stimulate the growth of the hair.
Internally, grass oil is sometimes administered as a carminative in
colic; and an infusion of the leaves of lemon grass is prescribed as
a diaphoretic and stimulant. In Europe and America the oils are used
almost exclusively by the soapmakers and perfumers.[2712]

[2711] In addition to which, there were “_842 dozens and 33 packages_”
of the same oil shipped to the United States. One ounce equal to 31·1
grammes.

[2712] The foliage of the large odoriferous species of _Andropogon_ is
used in India for thatching. It is eaten voraciously by cattle, whose
flesh and milk become flavoured with its strong aroma.

But the most remarkable use made of any grass oil is that for
adulterating _Attar of Rose_ in European Turkey. The oil thus employed
is that of _Andropogon Schœnanthus_ L. (see p. 725); and it is a
curious fact that its Hindustani name is closely similar in sound to
the word _rose_. Thus under the designation _Rusa_, _Rowsah_, _Rosa_,
_Rosé_, _Roshé_,[2713] it is exported in large quantities from Bombay
to the ports of Arabia, probably chiefly to Jidda, whence it is carried
to Turkey by the Mahommedan pilgrims. In Arabia and Turkey, it appears
under the name _Idris yàghi_, while in the attar-producing districts
of the Balkan it is known, at least to Europeans, as _Geranium Oil_ or
_Palmarosa Oil_. Before being mixed with attar, the oil is subjected to
a certain preparation, which is accomplished by shaking it with water
acidulated with lemon juice, and then exposing it to the sun and air.
By this process, described by Baur,[2714] the oil loses a penetrating
after-smell, and acquires a pale straw-colour. The optical and chemical
differences between grass oil thus refined and attar of rose are slight
and do not indicate a small admixture of the former. If grass oil is
added largely to attar, it will prevent its congealing.

=Adulteration=—The grass oil prepared by the natives of India is not
unfrequently contaminated with fatty oil.

Other Products of the genus Andropogon.

=Herba Schœnanthi vel Squinanthi=, _Juncus odoratus_, _Fœnum Camelorum_.

The drug bearing these names has had a place in pharmacy from the days
of Dioscorides down to the middle of the last century, and is still
met with in the East. The plant which affords it, formerly confounded
with other species, is now known to be _Andropogon laniger_ Desf., a
grass of wide distribution, growing in hot dry regions in Northern
Africa (Algeria), Arabia, and North-western India, reaching Thibet,
where it is found up to an elevation of 11,000 feet. Mr. Tolbort has
sent us specimens under the name of _Kháví_, gathered by himself in
1869 between Multán and Kot Sultán, and quite agreeing with the drug of
pharmacy. The grass has an aromatic pungent taste, which is retained in
very old specimens. We are not aware that it is distilled for essential
oil.

=Cuscus or Vetti-ver=[2715]—This is the long fibrous root of
_Andropogon muricatus_ Retz, a large grass found abundantly in
rich moist ground in Southern India and Bengal. Inscriptions on
copper-plates lately discovered in the district of Etawah, south-east
of Agra, and dating from A.D. 1103 and 1174, record grants of villages
to Brahmins by the kings of Kanauj, and enumerate the imposts that were
to be levied. These include taxes on mines, salt pits and the trade
in precious metals, also on mahwah (_Bassia_) and mango trees, and on
_Cuscus Grass_.[2716]

[2713] 50 cases, containing about 2250 lb., imported from Bombay, were
offered as “_Rose Oil_” at public sale, by a London drug-broker, 31
July, 1873.

[2714] See p. 267.

[2715] _Cuscus_, otherwise written _Khus-khus_, a name adopted by the
English in India, is probably from the Persian _Khas_. _Vetti-ver_ is
the Malyalim name of the plant.

[2716] _Proc. of Asiat. Soc. of Bengal_, Aug. 1873. 161.

Cuscus, which appears occasionally in the London drug sales, is used
in England for laying in drawers as a perfume. In India it serves for
making _tatties_ or screens, which are placed in windows and doorways,
and when wetted, diffuse an agreeable odour and coolness. It is also
used for making ornamental baskets and many small articles, and has
some reputation as a medicine.


RHIZOMA GRAMINIS.

_Radix Graminis_; _Couch Grass_, _Quitch Grass_, _Dog’s Grass_; F.
_Chiendent commun ou Petit Chiendent_; G. _Queckenwurzel_, _Graswurzel_.

=Botanical Origin=—_Agropyrum repens_ P. Beauv. (_Triticum repens_ L.),
a widely diffused weed, growing in fields and waste places in all parts
of Europe, in Northern Asia down to the region south of the Caspian,
also in North America; and in South America to Patagonia and Tierra del
Fuego.

=History=—The ancients were familiar with a grass termed [Greek
Agrôstis] and _Gramen_, having a creeping rootstock like that under
notice. It is impossible to determine to what species the plant is
referable, though it is probable that the grass _Cynodon Dactylon_
Pers., as well as _Agropyrum repens_, was included under these names.

Dioscorides asserts that its root taken in the form of decoction, is
a useful remedy in suppression of urine and vesical calculus. The
same statements are made by Pliny; and again occur in the writings
of Oribasius[2717] and Marcellus Empiricus[2718] in the 4th, and of
Aëtius[2719] in the 6th century, and are repeated in the mediæval
herbals,[2720] where also figures of the plant may be found, as
for instance in Dodonæus. The drug is also met with in the German
pharmaceutical tariffs of the 16th century. Turner[2721] and Gerarde
both ascribe to a decoction of grass root diuretic and lithontriptic
virtues. The drug is still a domestic remedy in great repute in France,
being taken as a demulcent and sudorific in the form of _tisane_.

[2717] _De virtute simplicium_, cap. i. (Agrostis).

[2718] _De medicamentis_, cap. xxvi.

[2719] Tetrabibli primæ, sermo i.

[2720] As in the _Herbarius Pataviæ_ printed in 1485, in which it is
said of _Gramen_—“aqua decoctionis ejus ... valet contra dissuriam ...
et frangit lapidem et curat vulnera vesicæ et provocat urinam....”

[2721] _Herball_, part 2, 1568. 13.

=Description=—Couch-grass has a long, stiff, pale yellow, smooth
rhizome, ⅒ of an inch in diameter, creeping close under the surface of
the ground, occasionally branching, marked at intervals of about an
inch by nodes, which bear slender branching roots and the remains of
sheathing rudimentary leaves.

As found in the shops, the rhizome is always free from rootlets, cut
into short lengths of ⅛ to ¼ of an inch, and dried. It is thus in the
form of little, shining, straw-coloured, many-edged, tubular pieces,
which are without odour, but have a slightly sweet taste.

=Microscopic Structure=—A transverse section of this rhizome shows
two different portions of tissue, separated by the so-called
nucleus-sheath. The latter consists of an unbroken ring of prismatic
cells, analogous to those occurring in sarsaparilla. In _Rhizoma
Graminis_, the outer part of the tissue exhibits a diffuse circle of
about 20 liber bundles, and the interior part about the same number
of fibro-vascular bundles more densely packed. The pith is reduced to
a few rows of cells, the rhizome being always hollow, except at the
nodes. No solid contents are to be met with in the tissue.

_Chemical Composition_—The constituents of couch-grass include no
substance to which medicinal powers can be ascribed. The juice of the
rhizome afforded to H. Müller[2722] about 3 per cent. of sugar, and
7 to 8 per cent. of _Triticin_, C₁₂H₂₂O₁₁, a tasteless, amorphous,
gummy substance, easily transformed into sugar if its concentrated
solution is kept for a short time at 110°C. When treated with nitric
acid, it yields oxalic acid. The rhizome affords also another gummy
matter containing nitrogen, and quickly undergoing decomposition; the
drug moreover is somewhat rich in acid malates. Mannite is probably
occasionally present as in taraxacum (p. 394), for such is the
inference we draw from the opposite results obtained by Stenhouse and
by Völcker. Starch, pectin and resin are wanting. The rhizome leaves 4½
per cent. of ash.

=Uses=—A decoction of the rhizome has of late been recommended in
mucous discharge from the bladder.

=Substitutes=—_Agropyrum acutum_ R. et S., _A. pungens_ R. et S., and
_A. junceum_ P. Beauv., by some botanists regarded as mere maritime
varieties of _A. repens_, have rootstocks perfectly similar to this
latter.

_Cynodon Dactylon_ Pers., a grass very common in the South of Europe
and the warmer parts of Western Europe, also indigenous to Northern
Africa as far as Sennaar and Abyssinia, affords the _Gros Chiendent_ or
_Chiendent pied-de-poule_ of the French. It is a rhizome differing from
that of couch-grass in being a little stouter. Under the microscope it
displays an entirely different structure, inasmuch as it contains a
large number of much stronger fibro-vascular bundles, and a cellular
tissue loaded with starch, and is therefore in appearance much more
woody. It thus approximates to the rhizome of _Carex arenaria_ L.,
which is as much used in Germany as that of _Cynodon_ in Southern
Europe. The latter appears to contain _Asparagin_ (the _Cynodin_ of
Semmola[2723]), or a substance similar to it.

[2722] _Archiv der Pharm._ 203. (1873) 17.

[2723] Della Cinodina, nuovo prodotto organico, trovato nella gramigna
officinale, _Cynodon Dactylon_.—_Opere minori di Giovanni Semmola_,
Napoli, 1841.—Abstracted in the _Jahresbericht_ of Berzelius, Tübingen,
1845. 535.




_II.—CRYPTOGAMOUS_ OR _FLOWERLESS PLANTS._




=_Vascular Cryptogams._=




LYCOPODIACEÆ.


SPORÆ LYCOPODII.

_Lycopodium_; _Semen vel Sporulæ Lycopodii_; F. _Lycopode_; G.
_Bärlappsamen_, _Hexenmehl_.

=Botanical Origin=—_Lycopodium clavatum_ L.—This plant, the Common
Clubmoss, is almost cosmopolitan. It is found on hilly pastures and
heaths throughout Central and Northern Europe from the Alps and
Pyrenees to the Arctic reunions, in the mountains of the east and
centre of Spain, throughout Russian Asia to Amurland and Japan, in
North and South America, the Falkland Isles, Australia and the Cape of
Good Hope. It occurs throughout Great Britain, but is most plentiful on
the moors of the northern counties.

The part of the plant employed in pharmacy is the minute spores, which,
as a yellow powder, are shaken out of the kidney-shaped capsules
or sporangia, growing on the inner side of the bracts covering the
fruit-spike.

The manner in which those sporæ are able to reproduce the mother plant
is not yet satisfactorily ascertained.[2724]

=History=—The Common Clubmoss was well known as _Muscus terrestris_
or _Muscus clavatus_, to the older botanists, as Tragus, Dodonæus,
Tabernæmontanus, Bauhin, Parkinson and Ray, by most of whom its
supposed virtues as a herb have been commemorated. Though the powder
(spores) was officinal in Germany, and used as an application to wounds
in the middle of the 17th century,[2725] it does not appear to have
been known in the English shops until a comparatively recent period.
It is not included by Dale[2726] in the list of drugs sold by London
druggists in 1692, nor enumerated in English drug lists of the last
century; and it never had a place in the London Pharmacopœia.

[2724] The few particulars may be found in the excellent description of
Lycopodium in Luerssen’s “_Medicinisch-pharmaceutische Botanik_,” i.
(Leipzig, 1878) 635, with figures.

[2725] Schröder, _Pharmacopœia Medico-chymica_, ed. 4, Lugd. 1656.
538.—Flückiger, “_Documente_” (quoted p. 404) 63. 68.

[2726] _Pharmacologia_, Lond. 1693.

=Description=—Lycopodium is a fine, mobile, inodorous, tasteless powder
of pale yellow hue, having at 16° C. a sp. gr. of 1·062. It floats on
water and is wetted with difficulty, yet sinks in that fluid after
boiling. By strong titration it coheres, assumes a grey tint, and
leaves an oily stain on paper; it may then be mixed with water. It is
immediately moistened by oily and alcoholic liquids, chloroform, or
ether. It loses only 4 per cent. of moisture when dried at 100° C. When
slowly heated, it burns away quietly, but when projected into flame, it
ignites instantly and explosively, burning with much light, an effect
exhibited by some other pulverulent bodies having a peculiar structure,
as fern spores and kamala.

=Microscopic Structure=—Under the microscope lycopodium is seen to
be composed of uniform cells or granules, 25 mkm. in diameter, each
bounded by four faces, one of which (the base) is convex, while the
others terminate in a triangular pyramid, the three furrowed edges of
which do not reach quite to the base. These tetrahedral granules are
marked by minute ridges, forming by their intersections, regular five-
or six-sided meshes. At the points of intersection, small elevations
are produced, which, under a low magnifying power, give the granules a
speckled appearance. Below this network lies a yellow, coherent, thin,
but compact membrane, which exhibits considerable power of resistance,
not being ruptured either by boiling water or by potash lye. Oil of
vitriol does not act upon it in the cold, even after several days;
but it instantly penetrates the grains and renders them transparent,
while at the same time numerous drops of oil make their appearance and
quickly exude.

=Chemical Composition=—One of the most remarkable constituents of
lycopodium spores is a fixed oil, which they contain to the astonishing
amount of 47 per cent. Bucholz pointed out its existence in 1807, but
obtained it only to the extent of 6 per cent. Yet if the spores are
thoroughly comminuted by prolonged trituration with sand, and are then
exhausted with chloroform or ether, we find that the larger proportion
above mentioned can be obtained. The oil is a bland liquid, which does
not solidify even at -15° C.

By subjecting lycopodium or its extract to distillation with or without
an alkali, Stenhouse obtained volatile bases, the presence of which
we can fully confirm; but they occur in exceedingly small proportion.
The ash of lycopodium amounts to 4 per cent.; it is not alkaline; it
contains alumina, and one per cent. of phosphoric acid, constituents
likewise found in the green parts of the plant.

=Production and Commerce=—To obtain lycopodium, the tops of the plant
are cut as the spikes approach maturity, taken home, and the powder
shaken out and separated by a sieve. It is collected chiefly in July
and August, in Russia, Germany and Switzerland. The quantity obtained
varies greatly by reason of frequent failures in the growth of the
plant.

France imported in 1870, 7262 kilo. (16,017 lb.) of lycopodium, chiefly
from Germany. The consumption in England is probably very much smaller,
but there are no data to consult.

=Uses=—Lycopodium is not now regarded as possessing any medicinal
virtues, and is only used externally for dusting excoriated surfaces
and for placing in pill boxes to prevent the mutual adhesion of pills.
It is also employed by the pyrotechnist.

=Adulteration=—The spores are so peculiar in structure, that they
can be distinguished with certainty by the microscope from all other
substances. It is only the species of clubmoss that are nearly related
to _L. clavatum_,[2727] that yield an analogous product, and this may
be used with equal advantage.

The pollen of phænogamous plants, as of _Pinus silvestris_, looks
at first sight much like lycopodium, but its structure is totally
different and very easily recognized by the microscope.

Water, even on boiling, is unable to dissolve anything from lycopodium;
slight traces of sulphate of calcium are not seldom met with in the
filtrate. Yet an undue proportion of gypsum will be detected by the
following methods:—

Starch and dextrin, which are sometimes fraudulently mixed with the
spores, are easily recognized by the well-known tests. Inorganic
admixtures, as gypsum or magnesia, may be detected by their sinking in
bisulphide of carbon, whereas lycopodium rises to the surface; or by
incineration, a good commercial drug leaving about 4 per cent. of ash.




FILICES.


RHIZOMA FILICIS.

_Radix Filicis maris_; _Male Fern Rhizome_, _Male Fern Root_; F.
_Racine de Fougère mâle_; G. _Farnwurzel_.

=Botanical Origin=—_Aspidium Filix mas_ Swartz (_Polypodium_ L.
_Nephrodium_ Michaux). The male fern is one of the most widely
distributed species, usually growing in abundance and, in temperate
regions, ascending as high as the arborescent vegetation. It occurs all
over Europe from Sicily to Iceland, in Greenland, throughout Central
and Russian Asia to the Himalaya and Japan; is found throughout China,
and again in Java and the Sandwich Islands, as well as in Africa from
Algeria to the Cape Colony and Mauritius. In North America it is
wanting in the Eastern United States, being principally replaced by
the nearly allied _Aspidium marginale_ Sw. and _A. Goldieanum_ Hook.;
but it is met with in Canada, California and Mexico, as well as in New
Granada, Venezuela, Brazil, and Peru.

=History=—The use of the rhizome of ferns as a vermifuge was well
known to the ancients,[2728] as Theophrastus, Dioscorides and Pliny
all giving curious descriptions of the plant. The remedy would appear
to have been administered also during the middle ages, for it was
again noticed by Valerius Cordus,[2729] and had a place in German
pharmaceutical tariffs of the sixteenth century as well as in
Schröder’s Dispensatory.[2730] Yet Tragus[2731] remarks that, at least
in Germany, the root was little used. It was in fact subsequently
nearly forgotten until revived by the introduction of certain secret
remedies for tapeworm, of which powdered male fern rhizome, combined
with drastic purgatives, was a chief constituent.

[2727] Especially _L. annotinum_, _L. complanatum_ and _L. inundatum_.

[2728] Murray, _Apparatus medicaminum_, v. (1790) 453-471.

[2729] Lib. 4, cap. 156 of the work quoted in the Appendix.

[2730] _Medicin-chymische Apotheke_, Nürnberg, 1656. 20.

[2731] P. 547 of the work quoted in the Appendix.

A medicine of this kind was prepared by Daniel Mathieu, a native of
Neuchâtel, born in 1741, who established himself as an apothecary
in Berlin. His treatment for the parasite was so successful that it
attracted the notice of Frederick the Great, who purchased his nostrum
for an annuity of 200 _thalers_ (£30), besides conferring upon him the
dignity of Aulic Councillor.[2732]

Great celebrity was also gained for the method of treating tapeworm
practised by Madame Nuffler or Nuffer, the widow of a surgeon at Murten
(Morat), likewise in Switzerland, who in 1775 obtained for the secret
from Louis XIV., after an inquiry by _savans_ of the period, the sum of
18,000 livres. Her method of treatment consisted in the administration
of—1. Panada made of bread with a little butter. 2. A clyster of salt
water and olive oil. 3. The “_spécifique_”—simply _powdered fern root_.
4. A purgative bolus of calomel, gamboge, acammony, and _Confectio
hyacinthidis_,—given in the foregoing order.[2733]

J. Peschier,[2734] a pharmacien of Geneva, recommended as a substitute
for the bulky powder of the root, an ethereal extract, an efficient
preparation, which though proposed in 1825, was scarcely used in
England until about 1851; at present it is the only form in which male
fern is employed. Peschier already observed a crystallized deposit in
his extract.

=Description=—The fresh rhizome or caudex is short and massive, 2-3
inches in diameter, decumbent, or rising a few inches above the ground,
and bearing on its summit a circular tuft of fronds, which in their
lower part are thickly beset with brown chaffy scales. Below the
growing fronds are the remains of those of previous seasons, which
retain in their firm, fleshy bases, vitality and succulence for years
after their upper portion has perished. From among these fleshy bases,
spring the black, wiry, branching roots.[2735] The rhizome is rather
fleshy, and easily cut with a knife, internally of a bright pale
yellowish green; it has very little odour and a sweetish astringent
taste. For pharmaceutical use, it should be collected in the late
autumn, winter or early spring, divested of the dead portions, split
open, dried with a gentle heat, reduced to coarse powder, and at once
exhausted with ether. Extract obtained in this way is more efficient
than that which has been got from rhizome that has been kept some time.

[2732] Cornaz, _Les familles médicales de la ville de Neuchâtel_, 1864.
20.

[2733] _Traitement contre le Ténia ou ver solitaire, pratiqué à Morat
en Suisse, examiné et éprouvé à Paris._ Publié par ordre du Roi, 1775.
4°, pp. 30. 3 plates, one representing the plant, its rhizome and
leaves.—Also English translation by Dr. Simmons, London, 1778. 8°.

[2734] _Bibliothèque Universelle_, xxx. (1825) 205; xxx. (1826) 326.

[2735] For a full account of the growth and structure of that rhizome
see Luerssen, _Medicinisch-pharmaceutische Botanik_, i. (1878) 504. 561.

=Microscopic Structure=—On transverse section of the rootstock, the
tissue shows rounded, somewhat polyhedral cells with porous walls;
the outer cells are brown and rather smaller, but do not exhibit the
regular flattened shape, usual in many suberous coats. Within this
cortical layer, there is a circle of about 10 large vascular bundles,
besides a large number of smaller ones scattered beyond the circle.
The leaf-bases exhibit a somewhat different structure, their vascular
bundles, usually 8, forming but one diffuse circle.

The cells of the parenchyme contain starch, greenish or brownish
granules of tannic matter, and drops of oil. In the green, vigorously
vegetating parts of the rootstock there are numerous smaller and larger
intercellular spaces, into which a few stalked glands project, as shown
by Prof. Schacht of Bonn in 1863. These globular glands originate from
the cells bordering the intercellular spaces. After their complete
development, and the appearance of starch in the adjacent parenchyme,
they exude a greenish fluid, which when thin slices of the rhizome are
kept some time in glycerin, solidifies in acicular crystals.[2736]
Such glands appear to be wanting in most of the allied ferns, such as
_Aspidium Oreopteris_ Sw. and _Asplenium Filix fœmina_ Bernh. They
have been observed by one of us (F.), in the small rhizome of _A.
spinulosum_ Sw. Similar glands, but not exuding a green liquid, occur
between the paleæ below the vegetating cone of the rootstock.

=Chemical Composition=—Of the numerous examinations which have been
made of this drug, those of Bock (1852), of Luck (1860), and of
Kruse (1876), may be especially mentioned. Besides the universally
distributed constituents of plants, there have been found in the
rhizome 5 to 6 per cent. of a green fatty oil, traces of volatile
oil, resin, tannin (Luck’s _Tannaspidic_ and _Pteritannic Acids_) and
crystallizable sugar, which according to Bock is probably cane sugar.

The medicinal ethereal extract, of which the rhizome yields about 8 per
cent., deposits a colourless, granular, crystalline substance, noticed
by Peschier as early as 1826, and subsequently designated by Luck,
_Filicic Acid_. Grabowski (1867) assigned it the formula C₁₄H₁₈O₅. We
learn from Prof. Buchheim that he regards filicic acid as the source
of the medicinal efficacy of the drug. By fusion with potash, filicic
acid is converted into phloroglucin and butyric acid. The green
liquid portion of the extract consists mainly of a glyceride called
_Filixolin_, from which Luck obtained by saponification two acids,
the one volatile, _Filosmylic Acid_, the other non-volatile, termed
_Filixolic Acid_.

Malin (1867) showed that the tannic acid of male fern may be decomposed
by boiling dilute acids into sugar and a red substance, _Filix-red_,
C₂₆H₁₈O₁₂, analogous to Cinchona-red.

Schoonbroodt[2737] performed some interesting experiments with _fresh_
fern root, showing that it contains _volatile acids_ of the fatty
series, among which is probably _formic_; but also a fixed acid,
accompanied by an oil of disagreeable odour. The liquid distilled from
the dried root did not evolve a similar odour, nor did it contain any
acid body. A small quantity of essential oil was obtained by means of
ether from the alcoholic extract of the fresh but not of the dried
rootstock. The rhizome of male fern yields 2 to 3 per cent. of ash,
consisting mainly of phosphates, carbonates, and sulphates of calcium
and potassium, together with silica.

[2736] The chemical nature of this body remains to be ascertained. The
crystals are probably _Filicic Acid_, accompanied by chlorophyl and
essential oil.

[2737] _Journal de Médecine de Bruxelles_, 1867 and 1868—also in the
_Jahresbericht_ of Wiggers and Husemann, 1869. 21.

=Uses=—The ethereal extract has been prescribed for all kinds of
intestinal worms; but recent experience goes to prove that its
effects are chiefly exhibited in cases of tapeworm. It is equally and
thoroughly efficacious in the three kinds respectively termed _Tænia
solium_, _T. medio-cannellata_ and _Bothriocephalus latus_.

=Substitution=—The rhizomes of _Asplenium Filix fœmina_ Bernh.,
_Aspidium montanum_ Vogl. (_A. Oreopteris_ Sw.) and _A. spinulosum_
Sw. may scarcely be mistaken for that of _A. Filix mas_. The best
means of distinguishing them is afforded by transverse sections of the
leaf-bases. In _Filix mas_, the section exhibits 8 vascular bundles,—in
the other ferns named, only 2,—a difference easily ascertained by
examination under a lens. Practically, no other indigenous fern than
_A. Filix mas_ affords a rhizome of sufficient bulk so as to be
remunerative. We are not acquainted with that of the American _Aspidium
marginale_ Swartz, the section of which shows 6 vascular bundles; its
extract is stated by Cressler (1878) to be perfectly active.




=_Thallogens._=




LICHENES.


LICHEN ISLANDICUS.

_Iceland Moss_; F. _Lichen ou Mousse d’Islande_; G. _Isländisches Moos_.

=Botanical Origin=—_Cetraria islandica_ Acharius.[2738]—It is abundant
in high northern latitudes, as Greenland, Spitzbergen, Siberia,
Scandinavia and Iceland, where it grows even in the plains. It is
found in the mountainous parts of Great Britain, France, Italy, and
Spain, in Switzerland (in elevations of nearly 10,000 feet), and in the
Southern Danubian countries. It also occurs in North America and in the
Antarctic regions.

=History=—In the North of Europe, this lichen has long been used
under the general name of _Mosi_, _Mossa_ or _Mus_,[2739] as an
article of food. It is the _Muscus crispæ Lactucæ similis_ of
Valerius Cordus,[2740] and was also mentioned by Ole Borrich, of
Copenhagen (1671), who called it _Muscus catharticus_, under the
notion that in early spring it possesses purgative properties.[2741]
The pharmaceutical tariff of the same city, of the year 1672,
likewise quotes _Muscus catharticus islandicus_.[2742] Its medicinal
employment in pulmonary disorders was favourably spoken of by Hjärne in
1683,[2743] but it is only since 1757 that it has come into general use
as a medicine, chiefly on the recommendation of Linnæus and Scopoli.

=Description=[2744]—The plant consists of an erect, foliaceous,
branching thallus, about 4 inches high, curled, channelled or rolled
into tubes, terminating in spreading truncate, flattened lobes, the
edges of which are fringed with short thick prominences. The thallus is
smooth, grey, or of a light olive-brown; the under surface is paler and
irregularly beset with depressed white spots. The apothecia (fruits),
which are not very common, appear at the apices of the thallus, as
rounded boss-like bodies, ²/₁₀ to ³/₁₀ of an inch across, of a dark,
rusty colour. The colour and mode of division of the thallus vary
greatly, so that many varieties of the plant have been distinguished.

[2738] _Cetraria_ from _cetra_, an ancient shield of hide, in allusion
to the circular apothecia.

[2739] These names are generally applied in Scandinavia and Iceland to
the smaller cryptogams, as lichens, true mosses, lycopodium, etc.

[2740] Hist. stirpium, quoted in the Appendix.

[2741] Bergius, _Materia Medica_, Stockholm, ii. (1778) 856.

[2742] Flückiger, _Documente_, quoted at page 404.

[2743] Murray, _Apparatus Medicaminum_, v. (1790) 510.

[2744] For an exhaustive account and figures see Luerssen (quoted at p.
734) p. 176.

In the dry state, Iceland moss is light, harsh and springy; it absorbs
water in which it is placed to the extent of a third of its weight,
becoming soft and cartilaginous; it ordinarily contains about 10 per
cent. of hygroscopic water. It is inodorous, but when wetted has a
slight seaweed-like smell; its taste is slightly bitter.

=Microscopic Structure=—A transverse section exhibits, when strongly
magnified, a broad loose central layer of long, thick-walled branching
walls of _hyphæ_, containing air, and enclosing wide hollow spaces.
This middle layer encloses a certain number of larger cells called
_gonidia_, coloured with chlorophyll. The gonidia are not destroyed
either by strong sulphuric acid, or by boiling them with potash. They
assume however a deep violet colour when treated with caustic potash
and then left for 24 hours in a solution of iodine in potassium iodide.

The tissues on either side of this central layer consists of very
thickly felted hyphæ, without intervening spaces, and does not appear
to contain any particular substance. This compact and tenacious tissue
passes into a thin cortical layer consisting of cells very closely
bound together. Under the influence of reagents this layer becomes very
evident: thus when moistened with strong sulphuric or hydrochloric
acid, it separates from the rest of the tissue as a coherent membrane,
and rolls itself backward. On boiling with water the inner tissue
swells up, the cell-walls being partly dissolved. Thin slices of
the lichen are coloured reddish or pale blue by iodine water,—more
distinctly blue, if previously treated with sulphuric acid. The colour
spreads uniformly over the inner tissue, but no starch granules can
be detected; the cortical layer is merely coloured brown by iodine.
The white spots on the outer surface of the thallus are resolved by
pressure under a plate of glass into minute round transparent granules,
not coloured by iodine, and thick branched cells like those of the
central layer.

The short thick prominences on the edge of the thallus, frequently
terminate in one or more sac-like cavities (_spermogonia_) containing
a large number of simple bar-shaped cells (_spermatia_), only 6 mkm.
long; they are enveloped in transparent mucus, and may be expelled
by pressure under glass. It has been shown by Stahl (1874) that
they represent the fertilizing corpuscles or seaweeds of the class
_Florideæ_.

The observations of De Bary (1866) and Schwendener (1867-70) confirmed
and much extended by the researches of Bornet[2745] (1873-74), have
shown that the gonidia of lichens are referable to some species of
_Alga_, and are capable of an independent existence; that the relations
of the hyphæ to the gonidia are of such a nature as to exclude the
possibility of either of those bodies being produced by the other;
and further that the theory of parasitism is the only one capable
of explaining these relations in a satisfactory manner. Under this
singular theory, lichens are compound organisms, formed of an alga, and
of a fungus living upon it as a parasite.

[2745] _Recherches sur les gonidies des Lichens._—_Ann. des Sciences
nat._ Bot. xvii. (1873) 45-110; 11 plates; also xix. (1874)
314-320.—For a complete abstract of these and all the more recent
investigations on this subject, see Luerssen (_l.c._) 186 _et seq._

=Chemical Composition=—Boiling water extracts from Iceland moss as
much as 70 per cent. of the so-called _Lichenin_, or _Lichen-starch_,
a body which is perfectly devoid of structure. The decoction (1:
20) gelatinizes on cooling, and assumes a reddish or bluish tint by
solution of iodine. This property of lichenin is plainly seen, when
the drug is first exhausted by boiling spirit of wine containing some
carbonate of potassium; and then boiled with 50 to 100 parts of water,
and the decoction precipitated by means of alcohol. The lichenin thus
obtained in a purer state, must be deprived of alcohol by cautiously
washing it with water. Powdered iodine will now immediately impart to
it while still moist an _intense blue_. Its composition, C₁₂H₂₀O₁₀,
agrees with that of starch and cellulose; and it must be regarded as
a modification of the latter, being likewise soluble in water and in
ammoniacal solution of copper. Lichenin is not a kind of mucilage,
because it yields but insignificant traces of mucic acid, if treated
with concentrated nitric acid; and also because it contains no
inorganic constituents.[2746] The very trifling proportion of mucic
acid it furnishes may depend upon the presence, in small amount, of an
independent mucilaginous body.

According to Th. Berg (1873), lichenin consists of what he continues
to call so, and another constituent, the latter only being coloured
by iodine, possessing (dextrogyre) rotatory power, and also being
insoluble in ammoniacal solution of copper. Berg’s lichenin is not
soluble in cold water, but readily dissolves in hot water, and again
separates on cooling. The other constituent on the contrary is
abundantly soluble in cold, and very sparingly in hot water. The drug
yielded to Berg 20 per cent. of “true” lichenin and 10 per cent. of the
other substance.

The chlorophyll of the gonidia is not soluble in hydrochloric acid, and
hence is distinguished by Knop and Schnedermann as _Thallochlor_; its
quantity is extremely small.

The bitter principle of Cetraria, called _Cetraric Acid_ or _Cetrarin_,
C₁₈H₁₆O₈, crystallizes in microscopic needles, is nearly insoluble in
cold water, and forms with alkalis, yellow, easily soluble, bitter
salts. The lichen also contains a little sugar, and about 1 per cent.
of a peculiar body, _Licheno-stearic Acid_, C₁₄H₃₄O₃, the crystals of
which melt at 120° C. The _Lichenic Acid_ found by Pfaff in 1826 in
Iceland moss, and formerly regarded as a peculiar compound, has been
proved identical with fumaric acid.

In common with many lichens, cetraria contains _Oxalic Acid_ and is
said to yield also some tartaric acid. The ash, which amounts to
1-2 per cent., consists to the extent of two-fifths of silicic acid
combined chiefly with potash and lime.

=Collection and Commerce=—Iceland moss is collected in many districts
where the plant abounds at least for local use, as in Sweden, whence
some is shipped to other countries. It is also gathered in Switzerland,
especially on the mountains of the Canton of Lucerne, and in
Spain.[2747] None is exported from Iceland.

[2746] The various mucilages and gums yield from 4 to 20 per cent. of
ash, but lichenin yields _none_.

[2747] _Cat. of Spanish Productions_,—London Exhibition, 1851.

=Uses=—It is given in decoction as a mild tonic, combined with more
active medicines. It is very little employed in Iceland, and only
in seasons of scarcity, when it is sometimes ground and mixed with
the flour used in making the _grout_ or grain soup. Occasionally it
is taken boiled in milk. It is not given, as has been asserted, to
domestic animals.

An interesting application of Iceland moss has recently been tried in
Sweden. Sten-Stenberg treats it with sulphuric or hydrochloric acid,
when 72 per cent. of grape sugar are formed, which may be converted
into alcohol.[2748]




FUNGI.




SECALE CORNUTUM.

_Ergota_; _Ergot of Rye_,[2749] _Spurred Rye_; F. _Seigle ergoté_; G.
_Mutterkorn_.

=Botanical Origin=—_Claviceps purpurea_ Tulasne, a fungus of the order
_Pyrenomycetes_, of which ergot is an immature form, it being the
_sclerotium_ (termed in the British Pharmacopœia _compact mycelium_ or
_spawn_) developed within the paleæ of numerous plants of the order
_Gramineæ_.

Ergot is obtained almost exclusively from rye, _Secale cereale_ L.;
but the same fungus is produced on grasses belonging to many other
genera, as _Agropyrum_, _Alopecurus_, _Ammophila_, _Anthoxanthum_,
_Arrhenatherum_, _Avena_, _Brachypodium_, _Calamagrostis_, _Dactylis_,
_Glyceria_, _Hordeum_, _Lolium_, _Poa_, and _Triticum_. Other organisms
of diverse form, but of doubtful specific distinctness, are developed
in _Molinia_, _Oryza_, _Phragmites_, and other grasses. In the order
_Cyperaceæ_ (e.g., _Scirpus_), peculiar ergots are known.

=History=—Although it is hardly possible that so singular a production
as ergot should be unnoticed in the writings of the classical authors,
we believe no undoubted reference to it has been discovered.[2750]
The earliest date under which we find ergot mentioned on account of
its obstetric virtues is towards the middle of the 16th century, by
Adam Lonicer of Frankfort, who describes its appearance in the ears
of rye, and adds that it is regarded by women to be of remarkable
and certain efficacy.[2751] It is also very clearly described in the
writings of Johannes Thalius, who speaks of it as used “_ad sistendum
sanguinem_.”[2752] In the next century it was noticed by Caspar Bauhin,
who termed it _Secale luxurians_,[2753] and by the English botanist
Ray,[2754] with allusion to its medicinal properties.

Rathlaw, a Dutch accoucheur, employed ergot in 1747. Thirty years later
Desgranges of Lyons prescribed it with success; but its peculiar and
important properties were hardly allowed until the commencement of the
present century, when Dr. Stearns of New York succeeded in gaining for
them fuller recognition.[2755] Ergot of rye was not, however, admitted
into the London Pharmacopœia until 1836.[2756]

[2748] Dingler’s _Polytechnisches Journal_, 197 (1870) 177; also
_Chemisches Centralblatt_, 1870. 607.

[2749] From the French _ergot_, anciently _argot_, a cock’s spur.

[2750] Consult Pliny’s _Nat. Hist._ book 18. ch. 44.

[2751] _Kreuterbuch_, ed. 1582. 285 (not in the edition of 1560).

[2752] _Sylva Hercynia_, Francof. 1588. 47.

[2753] _Pinax Theatri Botanici_, Basil. 1623. 23.

[2754] _Hist. Plant._ ii. (1693) 1241.

[2755] Stillé, _Therapeutics and Mat. Med._ ii. (1868) 609.

[2756] From 1825 to 1828 the wholesale price of ergot of rye in London
was from 36_s._ to 50_s._ per lb., that is to say, from twelve to
fifteen times its present value.

The use of flour containing a considerable proportion of ergot, gives
rise to a very formidable disease, distinguished in modern medicine as
_Ergotism_, but known in early times by a variety of names, as _Morbus
spasmodicus_, _convulsivus_, _malignus_, _epidemicus vel cerealis_,
_Raphania_, _Convulsio raphania_[2757] or _Ignis sancti Antonii_.

Some of the malignant epidemics which visited Europe after seasons of
rain and scarcity during the middle ages have been referred with more
or less of probability to ergot-disease.[2758] The chronicles of the
6th and 8th centuries note the occurrence of maladies which may be
suspected as due to ergotized grain. There is less of doubt regarding
the epidemics that prevailed from the 10th century and were frequent
in France, and in the 12th in Spain. In the year 1596 Hessen (Hessia)
and the adjoining regions were ravaged by a frightful pestilence, which
the Medical Faculty of Marburg attributed to the presence of ergot in
the cereals consumed by the population. The same disease appeared in
France in 1630, in Voigtland (Saxony) in the years 1648, 1649, and
1675; again in various parts of France, as Aquitaine and Sologne, in
1650, 1670, and 1674. Freiburg and the neighbouring region were visited
by the same malady in 1702; other parts of Switzerland in 1715-16;
Saxony and Lusatia in 1716; many other districts of Germany in 1717,
1722, 1736, and 1741-2.[2759] The last epidemic in Europe occasioned by
ergot appears to be that which, after the rainy season of 1816, visited
Lorraine and Burgundy, and proved fatal to many people of the poorer
class. Ergot disease is sometimes observed in Abyssinia at the present
day,[2760] and a few cases of it have even been lately recorded in
Bavaria.[2761]

=Formation=—The true nature of ergot has long been the source of a
great diversity of opinion, not set at rest by the admirable researches
of L. R. Tulasne, from whose _Mémoire sur l’Ergot des Glumacées_,[2762]
the following account is for the most part extracted.

[2757] Pereira, _Elem. of Mat. Med._ ii. (1850) 1007.

[2758] Consult Häser, _Lehrbuch der Geschichte der Medicin und der
Volkskrankheiten_, 1845. i. 256. 830, ii. 94; C. F. Heusinger,
_Recherches de Pathologie comparée_, Cassel, i. (1853) 543-554; Mérat
et De Lens, _Dict. Mat. Med._ iii. 131, vii. 268.

[2759] Tissot of Lausanne, _Phil. Trans._ lv. (1766) 106.—See also
Dodart, _Mém. de l’ Acad. R. des Sciences_, x., années 1666-1699
(Paris, 1730) 561; _Hist. de la Soc. Roy. de Méd._, année 1776. 345;
and _Mém. de Méd. et de Phys. méd._ année 1776. 260-311. 417.

[2760] Th. von Heuglin, _Reise nach Abessinien_ etc. Jena, 1868. 180.

[2761] Wiggers and Husemann, _Jahresbericht_ for 1870. 582.

[2762] _Ann. des Sciences nat._, Bot., xx. (1853) 1-56 and 4
plates.—More recent observations will be found in St. Wilson’s paper,
_Trans. of the Bot. Society of Edinburgh_, xli. (1876) 418-434 with
figures; and especially in Luerssen (quoted at p. 735) 156, _et seqq._

The formation of ergot often affects only a few caryopsides in a single
ear; sometimes, however, more than twenty. In the former case, the
healthy development of the other caryopsides is not prevented, but if
too many are attacked, the entire ear decays. The more isolated ergots
generally grow larger, and attain their greatest size on rye which
springs up here and there among other cereals.

The first symptoms of ergot-formation is the so-called _honey-dew of
rye_, a yellowish mucus, having an intensely sweet taste, and the
peculiar disagreeable odour frequently belonging to fungi. Drops
of this mucus show themselves here and there on the ears in the
neighbourhood of diseased grains, and attract ants and beetles of
various kinds, especially the yellowish-red _Rhagonycha melanura_
Fabr., but not bees. On this account the beetle in question has been
supposed to be instrumental in the development of ergot, and it may
possibly be so, but only by transporting the saccharine mucus from one
plant to another.

The honey-dew of rye contains neither oil-drops nor starch. After
dilution with water, it produces a rapid and abundant separation of
cuprous oxide from an alkaline solution of cupric tartrate. Dried over
sulphuric acid, it solidifies into a crystalline mass. After a few days
the drops of honey-dew dry up and disappear from the ear. The grain at
this period becomes completely disintegrated, and devoid of starch.

The ergotized soft ovaries are covered with, and penetrated by a white,
spongy, felted tissue, the _mycelium_ of the young fungus. It is made
up of slender, thread-like cells, the _hyphæ_, the outer layer of
which consists of radially-diverging cells, the _basidia_. The whole
mycelium forms by its crevices and folds a number of cavities opening
externally; from its outer layer, which is also called the _hymenium_
or _spermatophorum_, an immense number of agglutinated, elongated
granules, the _conidia_, are separated. These cells, the products
of the basidia, are not more than four mkm. in length, and give the
floral organs the appearance of being covered with a whitish dust. The
honey-dew likewise contains an abundance of conidia, but it is only
on dilution that they are precipitated and become easily perceptible;
the formation of the honey-dew is intimately connected with that of
the conidia themselves. Ergot in this primary or mycelium stage was
regarded as an independent fungus by Léveillé (1827), who named it
_Sphacelia segetum_. According to Kühn (1863), it may even be directly
by germination of the conidia within the ears of rye.

The mycelium penetrates and envelops the caryopsis, with the exception
of the apex, and thereby prevents its further growth, destroying
especially the epicarp and the embryo. At the base of the caryopsis,
there is formed by tumefaction and gradual transverse separation of
the thread-cells of the mycelium, a more compact kernel-like body (the
future ergot) violet-black without, white within, which gradually
but largely increases in size, and ultimately separates from the
mycelium as the loose tissue of the latter dries and shrinks up after
the completion of its functions. By this growth, the remains of the
caryopsis, still recognizable by their hairs and by the rudiments of
the style, as well as by the surviving portions of the mycelium-tissue,
become visible above the paleæ on the apex of the mature ergot, now
projecting prominently from the ear. Very rarely the ergot is crowned
by a fully developed seed; in the commercial drug, the apex is usually
broken off.

It is evident that in the process of development just described,
the very tissue of the caryopsis of the rye does not undergo a
_transformation_, but that it is _simply destroyed_. Neither in
external form, nor in anatomical structure does ergot exhibit any
resemblance to a caryopsis or a seed, although its development takes
place between the flowering time and that at which the rye begins to
ripen. It has been regarded as a complete fungus, and as such was named
by De Candolle (1816) _Sclerotium Clavus_ and by Fries _Spermædia
Clavus_.

No further change in the ergot occurs while it remains in the ear;
but laid on damp earth, interesting phenomena take place. At certain
points, small orbicular patches of the rind fold themselves back,
and gradually throw out little white heads. These increase in size,
whilst the outer layers of the neighbouring tissue gradually lose their
firmness and become soft and rather granular, at the same time that the
cells, of which they are made up, become empty and extended. In the
interior of the ergot, the cells retain their oil drops unaltered. The
heads assume a greyish-yellow colour, changing to purple, and finally
after some weeks stretch themselves towards the light on slender
shining stalks of a pale violet colour. The stalks often attain an inch
in length, with a thickness of about ½ a line. They consist of thin,
parallel, closely-felted cell-threads, devoid of fat oil. Ergot is
susceptible of this further development only so long as it is fresh,
that is to say, at most until the next flowering time of rye. Within
this period however, even fragments are capable of development. There
are sometimes also produced colourless threads of mould which belong
to other fungi, as _Verticillium cylindrosporum_ Corda, and which
frequently overgrow the _Claviceps_.[2763]

[2763] Ergot of rye collected by myself in August, placed upon earth in
a garden-pot and left in the open air unprotected through the winter,
began to develop the _Claviceps_ on the 20th March, and on another
occasion on the 20th April, at which date some sowed in February also
began to start, Sharp frost appears to retard the vegetation; thus,
after the cold winter of 1869-70, _Claviceps_, even in the greenhouse,
did not make its appearance before the 11th May. The earliest instance
of fully developed _ergots_ which I ever observed, occurred on the
11th of June; more frequently they are seen only in the beginning of
July.—F. A. F.

At the point where the stalk joins the spherical or somewhat flattened
head, the latter is depressed and surrounds the stalk with an annular
border. After a short time there appear on the surface of the head,
which is ⅒ of an inch in diameter, a number of brownish warts, in
which are the openings of minute cavities, the _conceptacula_ or
_perithecia_. On transverse section, they appear arranged radially
round the circumference of the head. In each cavity are a large number
of delicate sacs, only 3-5 mkm. thick, and about 100 mkm. long, the
_thecæ_ or _asci_, each containing, as is usual in fungi, 8 spores.
These are simple thread-shaped cells, filled with a homogeneous solid
mass.

The thicker ends of the spore-sacs (_asci_) open while still within
the perithecium; the spores issue united in a bundle, and are emitted
from the aperture of the perithecium. In consequence of their somewhat
glutinous consistence, they remain united even after their extrusion,
and form white silky flocks; their number in the 20 or 30 heads
sometimes produced from a single ergot, often exceeds a million. The
heads themselves die in two or three weeks after they have begun to
make their appearance. They represent the true fructification of the
fungus. This state of the plant appears to have been first noticed in
1801 by Schumacher, who called it _Sphæria_; it was subsequently known
as _Cordiceps_, _Cordyliceps_, _Kentrosporium_, etc., until Tulasne
proved it to be the final stage of development of ergot.

The three different forms of this structure, namely, the mycelium,
the ergot, and the fruit-bearing heads, are therefore merely
successive states of one and the same biennial fungus, which have
been appropriately united by Tulasne under the name of _Claviceps
purpurea_. The middle stage forms the _sclerotium_, which occurs in a
large number of the most various fungi, and is a special state of rest
of these plants. The direct proof that the mycelium is produced from
spores of the fruit-head sown on ears of rye, was supplied by Kühn in
1863. It has already been mentioned that the same organism is produced
from conidia; whence it appears that a twofold formation of ergot is
possible, as is frequently the case in other fungi.

=Description=—Spurred rye, as found in commerce, consists of fusiform
grains, which it is convenient to term _ergots_. They are from ⅓
to 1½ inch in length, and ½ to 4 lines in diameter; their form is
subcylindrical or obtusely prismatic, tapering towards the ends,
generally arched, with a longitudinal furrow on each side. At the
apex of each ergot, there is often a small whitish easily detached
appendage, while the opposite extremity is somewhat rounded. The
ergots are firm, horny, somewhat elastic, have a close fracture, are
brittle when dry, yet difficult to pulverize. The whitish interior
is frequently laid bare by deep transverse cracks. The tissue is but
imperfectly penetrated by water, even the thinnest sections swelling
but slightly in that fluid.

Ergot of rye has a peculiar offensive odour, and a mawkish, rancid
taste. It is apt to become deteriorated by keeping, especially
when pulverized, partly from oxidation of the oil, and partly from
the attacks of a mite of the genus _Trombidium_. To assist its
preservation, it should be thoroughly dried, and kept in closed bottles.

=Microscopic Structure=—In fully developed ergot, no organs can be
distinguished. It consists of uniform, densely felted tissue of short,
thread-like, somewhat thick-walled cells, which are irregularly packed,
and so intimately matted together that it is only by prolonged boiling
of thin slices with potash, and alternate treatment with acids and
ether, that the individual cells can be made evident. Without such
treatment, the cells even in the thinnest sections, show a somewhat
rounded, nearly isodiametric outline. This pseudo-parenchyme of ergot
exhibits therefore an aspect somewhat different from that of the
loosely felted cells (_hyphæ_) of other fungi. Ergot nevertheless is
not made up of cells differing from those of fungi generally. If thin
longitudinal slices of the innermost tissue are allowed to remain in
a solution of chromic acid containing about 1 per cent., they will
distinctly show the _hyphæ_, which are however considerably shorter
than those of other fungi. They contain numerous drops of fat oil, but
neither starch nor crystals. It is remarkable that this nearly empty
and not much thickened parenchyme should form so compact and solid a
tissue.

The cell-walls of the tissue of ergot are not coloured blue, even after
prolonged treatment with iodine in solution of potassium iodide; or
when the tissue has been previously treated with sulphuric acid, or
kept for days in contact with potash and absolute alcohol at 100° C. In
this respect the cellulose of fungi differs from that of phanerogamic
plants.

Of the outermost rows of cells in ergot, a few only are of a violet
colour, but they are not otherwise distinguishable from the colourless
tissue,—or at most by the somewhat greater thickness of their walls.

=Chemical Composition=—The composition of ergot has been elaborately
investigated by Wiggers as early as 1830. The drug contains about 30
per cent. of a non-drying, yellowish oil, chiefly consisting of olein,
palmitin, and small proportions of volatile fatty acids, especially
acetic and butyric, combined with glycerin. The large amount of oil
is remarkable; the fungi, dried at 100°, usually contain not more
than 5 per cent. of fat, mostly much less; they are on the other hand
much richer in albumin than ergot of rye. The oil of the latter, as
extracted by bisulphide of carbon, is accompanied by small quantities
of _resin_ and _cholesterin_ (see p. 420). It is erroneous to attribute
to this oil the poisonous properties of ergot, although it has been
shown by Ganser[2764] to display irritating properties when taken in
doses of about 6 grammes. But the effects observed appear dependent on
the presence in it of resin.

According to Wenzell (1864), ergot of rye contains two peculiar
alkaloids, which he designated _Ecboline_ and _Ergotine_,[2765] and
claimed to be the active principles of the drug. They were, however,
got merely as brownish amorphous substances.

The two bases of ergot are, according to Wenzell, combined with
_Ergotic Acid_, the existence of which has been further admitted by
Ganser. It is said to be a volatile body yielding crystallizable salts.

A crystallized colourless alkaloid, _Ergotinine_, C₃₅H₄₀N₄O₆, has been
isolated (1877-1878) by Tanret, a pharmacien of Troyes. He obtained
it to the amount of about 0·04 per cent., some amorphous ergotinine
moreover being present. Tanret exhausts the powdered drug with boiling
alcohol, which by evaporation affords a fluid resin and an aqueous
solution, besides a fatty layer. Some ergotinine is removed from the
resin by shaking it with ether, and mixed with the main liquid. This
is acidulated and purified by means of ether. Lastly, the ergotinine
is extracted by adding a slight excess of carbonate of potassium and
shaking with ether, and recrystallizing from alcohol. The solutions
of ergotinine turn very soon greenish and red; they are fluorescent.
Sulphuric acid imparts to it a red, violet, and finally blue hue.

Dragendorff and several of his pupils, since 1875, have isolated
the following _amorphous_ principles of the drug under notice:—(1)
_Sclerotic acid_ (doubtful formula C₁₂H₁₉}NO₉), said to be a very
active substance, chiefly in subcutaneous injections. About 4 per
cent. of colourless acid may be obtained from good ergot of rye. (2)
_Scleromucin_, a mucilaginous matter, which may be precipitated by
alcohol from aqueous extracts of the drug. Scleromucin when dried is
no longer soluble in water. (3) _Sclererythrin_, the red colouring
matter, probably allied to anthrachinon and the colouring substances of
madder, chiefly to purpurin. (4) _Sclerojodin_, a bluish-black powder,
soluble in alkalis. (5) _Fuscosclerotinic acid._ (6) _Picrosclerotine_,
apparently a highly poisonous alkaloid. Lastly (7) _Scleroxanthin_,
C₇H₇O₃ + OH₂; and (8) _Sclerocrystallin_, C₇H₇O₃, have been obtained in
crystals; their alcoholic solution is but little coloured, yet assumes
a violet hue on addition of ferric chloride.

Tanret also observed in ergot of rye a volatile _camphoraceous
substance_.

Ergot, in common with other fungi,[2766] contains a sugar termed
_Mycose_, closely allied to cane-sugar, and probably identical with
_Trehalose_ (see p. 417). Mycose crystallizes in rhombic octohedra,
having the composition C₁₂H₂₂O₁₁ + 2H₂O. Mitscherlich obtained of it
about one-tenth per cent. It appears that the sugar exuded in the first
stage of growth of the fungus,—the so-called _rye honey-dew_,—is in
its principal characters different from mycose. Instead of the latter,
Mitscherlich, as well as Fiedler and Ludwig, sometimes obtained from
ergot _Mannite_.

[2764] _Archiv der Pharm._ cxliv. (1870) 200.

[2765] The name _Ergotine_ has also been given to a medicinal extract
of ergot, prepared after a method devised by Bonjean, a pharmacien of
Chambéry, vide _Journ. de Pharm._ iv. (1843) 107; Pereira, _Elem. of
Mat. Med._ ii. (1850) 1012.

[2766] See Müntz in _Comptes Rendus_, lxxvi. (1873) 649.

Schoonbroodt also found in ergot _Lactic Acid_. Several other chemists
have further proved the presence of acetic and formic acids.

Starch is entirely wanting in ergot at all times. The drug yields about
3 per cent. of nitrogen, corresponding probably to a large amount of
albuminoid matter. Ganser, however, obtained only 3·2 per cent. of
albumin _soluble in water_.

When ergot or its alcoholic extract is treated with an alkali
it yields, as products of the decomposition of the albuminoid
matters, ammonia or ammonia-bases, according to Ludwig and Stahl,
_Methylamine_,—according to others, _Trimethylamine_. Manassewitz, as
well as Wenzell, state that phosphate of trimethylamine is present
in an aqueous extract of ergot, but Ganser ascertained that no such
base _pre-exists_ in ergot. We have found that the crystals which
abound in the extract, after it has been kept for some time, are an
acid phosphate of sodium and ammonium with a small proportion of
sulphate.[2767]

=Production and Commerce=—Ergot of rye is to be met with in all the
countries producing cereals; we have seen it in the high valleys of the
Alps, and Schübeler states that it grows in Norway, as far north as 60°
N. lat.

The drug is chiefly imported into London from Vigo in Spain and from
Tenerife; it is also shipped from Hamburg and France. Dr. de Lanessan,
writing to one of us from Vigo in 1872, remarks that vast quantities of
rye are grown in Galicia, and that owing to the humidity of the climate
the grain is extensively ergotized,—in fact the parasite is present
in one ear out of every three. At the time of harvest the ergots are
picked out, and the rye is thus rendered fit for food.

Southern and Central Russia furnish considerable supplies of the drug.
In the central parts of Europe, ergot does not everywhere occur in
sufficient abundance to be collected, and it greatly diminishes as the
state of agriculture improves. We have noticed that ergot from Odessa
was of a slaty hue and in much smaller grains than that from Spain.

=Uses=—Ergot is principally used on account of its specific action on
the uterus in parturition.

=Other Varieties of Ergot=—_Ergot of Wheat_ (Triticum vulgare), which
is in shorter and thicker ergots than that of rye, is picked out by
hand in some parts of Italy and France, from grain intended to be used
for the manufacture of vermicelli and other pastes; and such ergot is
sold to druggists. Carbonneaux Le Perdriel[2768] has endeavoured to
show that it is less prone to become deteriorated by age than that
of rye, and that it never produces the deleterious effects sometimes
occasioned by the latter.

[2767] The red colour of an alcoholic solution may serve for the
detection of small quantities of ergot in flour. The reaction with
potash, and evolution of the characteristic odour of herring brine may
assist in the same object. Extraction of the fatty oil with carbon
bisulphide may also be recommended as a test, inasmuch as good cereal
grains contain but a very small percentage of fat.

[2768] _De l’Ergot de Froment et de ses propriétés méd._ (thèse)
Montpellier, 1862.

The same writer asserts that _Ergot of Oat_ is sometimes collected and
sold either _per se_, or mixed with that of rye. It differs from the
latter in the ergots being considerably more slender.

Ergot of the North African grass _Arundo Ampelodesmos_ Cirillo, known
as _Diss_, has been collected for use, and according to Lallemant[2769]
is twice as active as that of rye. It is from 1 to 3 inches long by
only about ⅒ of an inch broad, generally arched, or in the large
ergots twisted spirally. We find it to share the structural character
of the ergot of rye; it is in all probability the same formation, yet
remarkably modified.




ALGÆ (FLORIDEÆ).




CHONDRUS CRISPUS.

_Fucus Hibernicus_; _Carrageen_,[2770] _Irish Moss_; F. _Mousse
d’Irlande_, _Mousse perlée_; G. _Knorpeltang_, _Irländisches Moos_,
_Perlmoos_.

=Botanical Origin=—_Chondrus crispus_ Lyngbye (_Fucus crispus_ L.),
a sea weed of the class _Florideæ_, abundant on rocky sea-shores of
Europe from the North Cape to Gibraltar; not frequent however in the
Baltic, and altogether wanting in the Mediterranean, but largely met
with on the eastern coasts of North America.

=History=—_Chondrus crispus_ was figured in 1699 by Morison,[2771] yet
only Todhunter at Dublin introduced it to the notice of the medical
profession in England in 1831, and shortly afterwards it attracted some
attention in Germany. It was never admitted to the London or British
pharmacopœia, and is but little esteemed in medicine.

=Description=—The entire plant is collected: in the fresh state it is
soft and cartilaginous, varying in colour from yellowish-green to livid
purple or purplish-brown, but becoming, after washing and exposure
to the sun, white or yellowish, and when dry, shrunken, horny and
translucent.

The base is a small flattened disc, from which springs a frond
or thallus 4 to 6 inches or more in length, having a slender
subcylindrical stem, expanding fan-like into wedge-shaped segments,
of very variable breadth, flat or curled, and truncate, emarginate or
bifid at the summit.

The fructification[2772] consists of tetraspores or cystocarps, rising
but slightly from the substance of the thallus, and appearing as little
wart-like protuberances.

In cold water, carrageen swells up to its original bulk, and acquires
a distinct seaweed-like smell. A quantity of water equal to 20 or
30 times its weight, boiled with it for ten minutes, solidifies on
cooling to a pale mawkish jelly.

[2769] _Etude sur l’Ergot du Diss_, Alger et Paris, 1863; _Journ. de
Pharm._ i. (1865) 444.

[2770] _Carrageen_ in Irish signifies _moss of the rock_. We learn from
an Irish scholar that it would be more correctly written _carraigeen_.

[2771] _Plantar. hist. universal._ Oxon. iii. tab. 11.

[2772] See Luerssen (quoted at p. 734) i. 124 _et seq._

=Microscopic Structure=—The tissue of _Chondus crispus_ is made up of
globular or elongated, thick-walled cells. The superficial layers on
both sides of the lobes constitute a kind of peel, easily separable in
microscopic sections. The interior or medullary part exhibits a much
less densely packed tissue formed of larger cells. The larger cavities
of this tissue contain a granular mucilaginous matter, assuming a
slight violet tinge on addition of iodine. In water however, the
cell-walls swell up so as to form a gelatinous mass, in which separate
cells can at last be scarcely distinguished.[2773] In the fresh state,
its cells also contain granules of chlorophyll imbued with a red
matter, termed _Phyco-erythrin_. But by washing and exposure to the
air, these colouring substances are removed or greatly altered, and are
no longer visible in the commercial drug.

=Chemical Composition=—The constituents of carrageen are those
generally found in marine algæ, especially as regards the mucilage.
This latter is insoluble in an ammoniacal solution of copper
(Schweizer’s test); by the action of fuming nitric acid, it yields,
in common with gum, an abundance of mucic acid. The mucilage of
carrageen, like many similar bodies, obstinately retains inorganic
matter; after it had three times been dissolved in water, and as many
times precipitated with alcohol, we found it still to yield the same
quantity of ash as the raw drug itself, that is to say, more than 15
per cent. The mucilage, perfectly dried, is a tough horny substance, of
a greyish colour; it quickly swells up in water, forming a jelly which
is precipitable by neutral acetate of lead.

By boiling carrageen for a week with water containing 5 per cent.
of sulphuric acid, Bente (1876) obtained crystals of _lævulinic
acid_, C₅H₈O₃, and an amorphous sugar. The former is also afforded by
cellulose of pine wood and by paper.

According to Blondeau,[2774] the mucilage of carrageen contains 21 per
cent. of nitrogen and 2·5 of sulphur, a statement which we are able to
point out as erroneous. We find in it no sulphur, and only 0·88 per
cent. of nitrogen. The drug itself yielded us not more than 1·012 per
cent. of nitrogen.

When thin slices of the plant are treated with alcoholic potash, and
then after washing left for 24 hours in contact with a solution of
iodine in potassium iodide, they acquire a deep blue; yet, starch
granules are not found in this seaweed. Lastly in connexion with
carrageen may be mentioned _Fucusol_, an oily liquid isomeric with
furfurol, obtained by boiling seaweeds with dilute sulphuric acid.

=Commerce=—The plant is collected on the west and north-west coast
of Ireland: Sligo is said to be a great depôt for it. Carrageen of
superior quality is sometimes imported from Hamburg.

[2773] Alcohol, glycerin or a fatty oil are the liquids most suited for
the microscopic examination of this drug.

[2774] _Journ. de Pharm._ ii. (1865) 159.

The largest quantities of carrageen, sometimes half a million pounds
a year, are gathered near Minot Ledge lighthouse, Scituate, Plymouth
county, on the coast of Massachusetts, where a systematic process of
preparing it for the market is adopted.[2775]

=Uses=—The mucilaginous decoction and jelly which carrageen affords are
popular remedies in pulmonary and other complaints; but as nutriment
such preparations are much over-estimated.[2776]

Carrageen is sometimes used for feeding cows and calves; and under the
name of _Alga marina_, for stuffing mattresses. It is largely used
for industrial purposes, like other mucilaginous matter. Its mucilage
serves for thickening the colours employed in calico-printing, and as
size for paper and for cotton goods. In America it is used for fining
beer.

=Substitutes=—_Gigartina mammillosa_[2777] J. Agardh (_Chondrus
mammillosus_ Grev.) is collected indiscriminately with _Ch. crispus_.
It is distinguished from the latter chiefly by having the flat portion
of the thallus beset with elevated or stalked tubercles, bearing the
cystocarps; but it has the same properties. _G. acicularis_ Lamouroux,
a species common on the coasts of France and Spain, and having slender
cylindrical branches, is occasionally collected along with _Chondrus
crispus_. Dalmon (1874) who has examined it, asserts it to be less
soluble in boiling water than true carrageen. Small quantities of other
seaweeds are often present through the negligence of the collectors.


FUCUS AMYLACEUS.

_Alga Zeylanica_; _Ceylon Moss_,[2778] _Jaffna Moss_.

=Botanical Origin=—_Sphærococcus lichenoides_ Agardh. (_Gracillaria
lichenoides_ Grev., _Plocaria candida_ Nees), a light purple or
greenish seaweed, belonging to the class _Florideæ_, occurring on the
coasts of Ceylon, Burma, and the Malay islands.[2779]

=History=—Ceylon moss has long been in use among the inhabitants of the
Indian Archipelago and the Chinese. It is probably one of the plants
described by Rumphius[2780] as _Alga coralloides_. In recent times it
was brought to the notice of European physicians by O’Shaughnessy.[2781]

=Description=—The plant, which as found in commerce is opaque and
white, having been deprived of colour by drying in the sun and air,
consists of cylindrical ramifying stems or filaments, ⅒ of an inch
in diameter and from 1 to 6 or more inches in length. The main stems
bear numerous branches, simple or giving off slender secondary or
tertiary ramifications, ending in a short point. When moistened, the
plant increases a little in volume, becomes rather translucent, and
frequently exhibits whitish globular or mammiform fruits (cystocarps).
It is somewhat friable, and after drying at 100° C. may easily be
powdered. It is devoid of taste and smell, in this respect differing
from most sea weeds.

[2775] Bates in _Amer. Journ. of Pharm._ 1868. 417; also _Pharm.
Journ._ xi. (1869) and viii. (1877) 304.

[2776] A person must eat a _pound_ of stiff jelly made of the powdered
seaweed before he would have swallowed _half an ounce_ of dry solid
matter.

[2777] Fig. in Luerssen (quoted at p. 734) 126.

[2778] For convenience we accept the popular name of _moss_, though it
is no longer in accordance with the signification of the word in modern
science (see p. 737, note 2).

[2779] The _Pharmacopœia of India_ (1868) names _Sphærococcus
confervoides_ Ag. (_Gracillaria_ Grev.), a plant of the Atlantic Ocean
and Mediterranean, not uncommon on the shores of Britain, as furnishing
a portion of the drug under notice. Specimens which we have examined
are widely different in structure from _S. lichenoides_, and are
apparently devoid of starch.

[2780] _Herb. Amboin._ vi. lib. xi c. 56.

[2781] _Indian Journ. of Med. Science_, Calcutta, March, 1834; _Bengal
Dispensatory_, 1841. 668.

=Microscopic Structure=—The transverse section shows a loose tissue
made up of large empty cells, enclosed by a cortical zone 30 to 70
mkm. thick. This zone consists of small cells, loaded with globular
starch granules, from less than 1 up to 3 mkm. in diameter, so densely
packed as to form what seems at first sight a single mass in each cell.
In the larger cells the granules are attached to the walls; they do
not display in polarized light the usual cross. The thick walls of
the cells show a stratified structure, especially after having been
moistened with chromic acid; on addition of a solution of iodine in an
alkaline iodide, they assume a deep brown, but the starch granules,
which also abound in the cystocarps, display the usual blue tint.

=Chemical Composition=—The drug, as examined by O’Shaughnessy, yielded
in 100 parts of vegetable jelly 54·5, starch 15·0, ligneous fibre
(cellulose?) 18·0, mucilage 4·0, inorganic salts 7·5.

Cold water removes the mucilage, which, after due concentration, may
be precipitated by neutral acetate of lead. This mucilage, when boiled
for some time with nitric acid, produces oxalic acid and microscopic
crystals of mucic acid (beautifully seen by polarized light), soluble
in boiling water and precipitating on cooling. With one part of
the drug and 100 parts of boiling water a thick liquid is obtained
which affords transparent precipitates with neutral acetate of lead
or alcohol, in the same way as carrageen. With 50 parts of water, a
transparent tasteless jelly, devoid of viscosity, is produced; in
common with the mucilage, it furnishes mucic acid, if treated with
nitric acid. Micro-chemical tests do not manifest albuminous matter in
this plant.

Some chemists have regarded the jelly extracted by boiling water as
identical with pectin, but the fact requires proof. Payen[2782] called
it _Gelose_, and found it composed of carbon 42·77, hydrogen 5·77,
and oxygen 51·45 per cent. Gum Arabic contains carbon 42·12, hydrogen
6·41, and oxygen 51·47 = C₁₂H₂₂O₁₁. Payen’s gelose imparts a gelatinous
consistence to 500 parts of water; it is extracted by boiling
water from the plant previously exhausted by cold water slightly
acidulated.[2783]

The inorganic salts of Ceylon moss consist, according to O’Shaughnessy,
of sulphates, phosphates, and chlorides of sodium and calcium, with
neither iodide nor bromide. Dried at 100° C., it yielded us 9·15 per
cent. of ash.

=Uses=—A decoction of Ceylon moss made palatable by sugar and
aromatics, has been recommended as a demulcent, and a light article
of food for invalids. In the Indian Archipelago and in China, immense
quantities of this and of some other species of seaweed[2784] are used
for making jelly and for other purposes.

[2782] _Comptes Rendus_, xlix. (1859) 521; _Pharm. Journ._ i. (1860)
470. 508.

[2783] Gelose even in the moist state is but little prone to change,
and the jelly made by the Chinese as a sweetmeat which consists mainly
of it, will keep good for years.

[2784] Consult Martius, _Neues Jahrb. f. Pharm._ Bd. ix. März 1858;
Cooke, _Pharm. Journ._ i. (1860) 504; Holmes, _Pharm. Journ._ ix.
(1878) 45.




APPENDIX.


SHORT BIOGRAPHIC AND BIBLIOGRAPHIC NOTES,

Relating to Authors and Books quoted in the Pharmacographia. They may
be completed by consulting especially the following works:—

CHOULANT, Geschichte und Literatur der älteren Medicin, Part I.,
Bücherkunde für die ältere Medicin. 1841.

KOPP, Geschichte der Chemie, 4 vols., 1843-1847.

MEYER, Geschichte der Botanik, 4 vols., 1854-1857.

PEREIRA, Tabular view of the history and literature of the Materia
Medica, in the “Elements of Materia Medica,” vol ii. part ii. (1857)
836-869.

PRITZEL, Thesaurus literaturæ botanicæ. 1872.

=Acosta=, Christóbal, physician at Burgos; he travelled in the east and
visited Mosambique and Cochin; died A.D. 1580.—_Tractado_ de las Drogas
y medicinas de las Indias Orientales con sus Plantas debuxadas al
biuvo por Christoual Acosta medico y cirujano que las vio ocularmente.
Burgos, 1578. Small 4°, 448 pages (and 38 pages indices). There are
translations in Latin by _Clusius_, 1582; in Italian, 1585; in French
by _Antoine Colin_, 1619, etc.

See pages 154. 423. 462. 503. 565.

=Actuarius, Johannes=, a physician to the court of Constantinople,
towards the end of the 13th century, author of “_Methodus medendi_,”
and “_De medicamentorum compositione_.” Both these works were
repeatedly printed during the 16th century; we are not aware of any
recent editions.

See pages 222. 263.

=Ægineta=—See =Paulos=.

=Aëtius= of Amida, now Diarbekir, on the upper Tigris. He wrote,
probably about A.D. 540-550, Aëtii medici græci ex veteribus medicinæ
_Tetrabiblos_. Basileæ, 1542.

See pages 35. 175. 271. 511. 559.

=Albertus Magnus= (Count Albert von Bollstädt), 1193-1280, a Dominican
monk, Bishop of Regensburg (Ratisbon).—Alberti Magni ex ordine
Prædicatorum _De vegetabilibus_ libri vii., historiæ naturalis pars
xviii. Edit. E. Meyer and C. Jessen. 1867.

See pages 543. 568. 678.

=Alexander Trallianus=, of Tralles, now Aïdin-Güsilhissar, south-east
of Smyrna, an eminent physician who wrote about the middle of the 6th
century of our era, possibly at Rome.—Alexandri Tralliani medici libri
xii. Edit. Joanne Guintero. Basileæ, 1556. 8vo.—An admirable German
translation, together with the Greek original, has been published at
Vienna, 2 vols., 1878-1879, by Puschmann.

See pages 6. 222. 281. 325. 388. 493. 529. 595. 680.

=Alexandria=, the Roman custom-house of.

In the Pandects of Justinian there is to be found a curious list
of eastern drugs and other articles liable to duty at the Roman
custom-house in Alexandria, from the time of Marcus Aurelius and
Commodus, about A.D. 176-180. The complete list is reprinted in
Vincent, Commerce of the Ancients, ii. (1807) 698; also in Meyer,
Geschichte der Botanik, ii. (1855) 167.

See pages 222. 315. 321. 493. 577. 635. 644.

=Alhervi.= Abu Mansur Movafik ben Ali Alherui, a Persian physician of
the 10th century. He compiled a work on medicines and food from Greek,
Arabic, and Indian sources, which was published and partly translated
by Seligmann: Liber _fundamentorum pharmacologiæ_ ... epitome codicis
manuscripti persici bibl. caes. reg. Vienn. Vindobonæ, 1830-1833.

See pages 12. 225. 325. 490.

=Alkindi.= Abu Jusuf Jakub ben Ishak ben Alsabah Alkindi. He wrote
about A.D. 813-841 at Basra and Bagdad, about various subjects of
natural philosophy, mathematics, medicine, music.

See page 642.

=Alphita=, a curious list of drugs and pharmaceutical preparations,
probably compiled in the 13th century, and originally written in French
(according to Häser, Geschichte der Medicin, i. 1875, 648 sqq.).
Daremberg, La médecine, histoire et doctrine, 1865, attributes the
Alphita to Maranchus. The Alphita is contained in Salvatore de Renzi’s
_Collectio Salernitana_; ossia documenti inediti ... alla scuola medica
Salernitana, iii. (Napoli, 1854) 270-322.

See page 377.

=Alpinus=, Prosper, 1553-1617, Professor of Botany and “Ostensore dei
Semplici,” _i.e._ teacher of drugs, in the University of Padua. He
visited Egypt in 1580-1583. _De Plantis Ægypti_ liber etc. Venetiis,
1592.

See pages 44. 94. 222. 425. 500.

=Alrasis= or =Arrasi=—See =Rhazes=.

=Angelus= a Sancto Josepho, originally Joseph Labrousse, of Toulouse,
born 1636, died in 1697. He was at Ispahan as a Carmelite monk in 1664,
and published in 1681 at Paris a Latin translation of what he called a
_Pharmacopœia Persica_. Consult Lucien Leclerc, Histoire de la médecine
arabe, ii. (Paris, 1876) 84.

See pages 12. 415. 548.

=Anguillara=, Luigi (born at Anguillara, died in 1570 at Ferrara),
“Ostensor simplicium,” _i.e._ professor of materia medica, in the
University of Padova; author of _Semplici_, liquali in piu Pareri a
diversi nobili huomini scritti appaiono. Vinegia, 1561.

See page 303.

=Arrianos Alexandrinos=—See =Periplus=.

=Avicenna.= Abu Ali Alhosain Ben Sînâ Albochâri (of Bokhara), 980-1037.
A learned philosopher, mathematician, student of medicine, minister,
etc., the most celebrated among Arab physicians, their “doctor
princeps.” His “_Canon medicinæ_” was admired until the end of the 15th
century as the most complete system of medicine, of which there are
numerous editions, chiefly translations. We have particularly referred
to “Avicennæ libri in re medica omnes, lat. redditi a J. P. _Mongio_ et
J. _Costæo_,” 2 vols. Venetiis, ap. Vinc. _Valgrisium_, 1564.

See pages 12. 31. 125. 161. 225. 393. 429. 490. 642. 716.

=Ayurvedas=—See =Susrutas=.

=Baitar.= Abu Mohammad Abdallah Ben Ahmad Almaliqî (of Malaga),
called _Ibn Baitar_. He travelled from Spain to the east, lived
about 1238-1248 as a physician to the court in Egypt, and died in
1248 at Damascus. His great work on Materia Medica—Liber magnæ
collectionis simplicium alimentorum et medicamentorum—has been (very
unsatisfactorily) translated into German by Joseph von Sontheimer, 2
vols. Stuttgart, 1840-1842.

See pages 4. 31. 115. 211. 305. 383. 415. 425. 462. 488. 490. 675.

=Barbosa=, Odoardo (Duarte Balbosa), a Portuguese who visited Malacca
before 1511, and accompanied Magalhaes in his famous circumnavigation;
killed in 1522 by the natives of the Philippines. Barbosa wrote in 1516
an excellent account of India, published in Ramusio’s collection, Delle
navigationi et viaggi, _&c._ Venetia, 1854. Libro di Odoardo Barbosa
Portoghese, fol. 413-417. Also in “Coasts of East Africa and Malabar,”
published for the Hakluyt Society, London, 1866.—Barbosa quotes the
prices of many drugs found in 1511-1516 at Calicut. An abstract of this
interesting list will be found in Flückiger, Documente zur Geschichte
der Pharmacie. Halle, 1876, 15.

See pages 43. 241. 405. 521. 595. 600. 644. 672. 675. 717.

=Batutah.= Abu Abdallah Mohammed ... Allawati Aththangi, called
Ibn Batuta, of Tangier, in Morocco. 1303-1377. The greatest of
the Arabic travellers; he visited the east as far as the Caspian
regions, Delhi, Java, and Pekin, and also Northern Africa as far
as Timbuktu.—_Voyages_ d’Ibn Batouta, texte arabe accompagné d’une
traduction par C. Defrémerie et B. R. Sanguinetti. 2 vols. Paris.
1853-1854.

See pages 404. 511. 521. 577. 669. 672.

=Bauhin=, Caspar, 1560-1624, professor of anatomy and botany in
the University of Basel. See Hess, J. W. Kaspar Bauhin’s Leben und
Charakter. Basel, 1860. 72 pages.—_Pinax_ theatri botanici. Basileæ,
1623.

See pages 31. 86. 388. 429. 439. 731. 740.

=Belon=, Pierre, 1517-1564, called Belon “du Mans,” with reference to
his native country near Le Mans, in the ancient province of Maine,
France. He travelled in the Levant from 1546 to 1549, and wrote Les
observations de plvsievrs _singvlaritez_ et choses memorables, trouuées
en Grèce, Asie, Iudée, Egypte, Arabie, et autres pays estranges. Paris,
1553.

See pages 175. 222. 254. 598. 615.

=Benedictus Crispus= (Benedetto Crespo), A.D. 681, Archbishop of Milan,
died in 725 or 735.—_Commentarium_ medicinale, ed. by Ullrich, 1835,
a small pamphlet consisting of 241 verses, in which a few drugs are
alluded to.

See pages 282. 463. 493.

=Bock=—See =Tragus=.

=Brunfels=, Otto, 1488-1534, originally a Carthusian friar, then
a schoolmaster at Strassburg, author of several pamphlets against
Catholicism; doctor of medicine, and lastly physician to the republic
of Bern. His great work—Herbarum vivæ _eicones_, etc., 3 vol.,
Strassburg, 1530, 1531, 1536, containing 229 partly excellent woodcuts
of plants occurring near Strassburg—is the earliest instance of good
botanical figures.—See Flückiger, _Otto Brunfels_, in the Archiv der
Pharmacie, vol. _212_ (1878) 493-514.

See pages 170. 388. 439. 694.

=Brunschwyg=, Hieronymus, a surgeon living at Strassburg apparently
towards the end of the 15th century. His “_Liber de arte distillandi_
de simplicibus, Das buch der rechten kunst zu distilieren....”
Strassburg, 1500, with figures, was subsequently brought out in
numerous editions and translations. In English: The noble handy work of
surgery and of destillation. Southwark, 1525, fol., and The vertuose
boke of distillacyon of the waters of all manner of herbes, translate
out of duyche. London, 1527, fol.—See Choulant, Graphische Incunabeln
für Naturgeschichte und Medicin, 1858-75.

See pages 170. 456.

=Camellus= or =Camelli=—See =Kamel=.

=Camerarius=, Joachim, 1534-1598, physician at Nürnberg. _Hortus
medicus et philosophicus._ Francofurti, 1588. See _Irmisch_, Über
einige Botaniker des 16ᵗᵉⁿ Jahrhunderts. Sondershausen, 1862, 4°. p. 39.

See pages 384. 390. 474.

=Cato=, Marcus Porcius Cato Censorius, 234-149 b.c. In the book _De
re rustica_, the earliest agricultural work in Roman literature, Cato
treats of many useful plants, the complete list of which will be found
in Meyer’s Geschichte der Botanik, i. 342. We have usually referred to
_Nisard’s_ edition in “Les Agronomes latins,” Paris, 1877.

See pages 172. 245. 269. 289. 329. 627.

=Celsus=, Aulus Cornelius; about 25 B.C. to A.D. 50.—A. Cornelii Celsi
de medicina libri octo, ed. C. Daremberg. Lipsiæ, 1859. The list of
useful plants mentioned by him will be found in Meyer’s Geschichte der
Botanik, ii. 17.

See pages 35. 43. 179. 234. 291. 439. 493. 677. 680.

=Charaka=, _i.e._ book of health. An old Sanskrit work, analogous to
Susruta’s Ayurvedas (see Susruta), yet reputed in India to be older
than the latter. Charaka is now being published, since 1868, at
Calcutta, and also at Bombay, but is not yet translated in any modern
idiom. There are Arabic versions of the end of the 8th century, as
stated by Albirûnî in the 11th century, and by Ibn Baitar (see B.)
For further particulars consult Roth, _Zeitschrift der Deutschen
Morgenländischen Gesellschaft_, xxvi. (1872) 441 sqq.

=Charlemagne=, the great Emperor, 768-814. He ordered, in 812, by
the “_Capitulare_ de villis et cortis imperialibus,” a considerable
number of useful plants to be cultivated in the imperial farms. Several
other plants are also mentioned, for similar purpose, in the Emperor’s
“_Breviarium_ rerum fiscalium.” A full account of both these remarkable
documents will be found in Meyer’s Geschichte der Botanik, iii.
401-412. See also B. Guérard, Explication du Capitulaire de Villis;
Bibliothèque de l’Ecole des Chartes, IV. (1853) 201-247. 313-350. and
346-572.

See pages 92. 98. 172. 179. 245. 269. 308. 329. 488. 542. 545. 627.

=Chordadbeh=—See =Khurdadbah=.

=Circa instans=—See =Platearius=.

=Clusius=, Charles de l’Escluse, born at Arras, in the north of
France, A.D. 1526; died A.D. 1609. He lived at Marburg, Wittenberg,
Frankfurt, Strassburg, Lyons, Montpellier; travelled in Spain and
Portugal; paid, in 1571, a visit to London, and again in a later year.
Clusius was, from 1573 to 1587, the director of the imperial gardens at
Vienna, and from 1593 to 1609 professor of botany in the University of
Leiden. Among the works of this eminent man the most important, from a
pharmaceutical point of view, are: 1. Aliquot _notæ_ in Garciæ aromatum
historiam. Antverpiæ, 1582. 2. _Rariorum plantarum historia._ Antv.,
1601. 3. _Exoticorum libri decem._ Antv., 1605.—See Morren, Charles de
l’Ecluse, sa vie et ses œuvres. Liége, Boverie, No. 1, 1875, 59 pp.

See pages 17. 21. 73. 83. 96. 202. 211. 254. 272. 287. 390. 401. 425.
429. 453. 521. 589. 648. 657.

=Collectio Salernitana=—See =Alphita=.

=Columella=, Lucius Junius Moderatus. Born at Cadiz; he wrote between
A.D. 35 and 65 the most valuable agricultural work of the Roman
literature: “_De re rustica_ libri xii.” It has been translated by
_Nisard_, together with Columella’s book, “_De arboribus_,” for Firmin
Didot’s “Agronomes latins.” Paris, 1877. The list of the numerous
plants mentioned by Columella will be found in Meyer’s Geschichte der
Botanik ii., 68.

See pages 97. 245. 664.

=Constantinus Africanus=. Born at Carthage in the second half of the
10th century. A physician who spent his life in travels in the east and
in studies in the medical school at Salerno (see S.), and in the famous
Benedictine Abbey of Monte Cassino; died A.D. 1106. He transmitted the
medical knowledge of the Arabs to the school of Salerno, of which he
may be called the most distinguished fellow. See _Steinschneider_ in
_Virchow’s Archiv für patholog. Anatomie und Physiologie_, 37 (1866)
351; and in _Rohlfs’_ Archiv für Geschichte der Medicin, 1879, 1-22.
Steinschneider shows that Constantin’s work, De Gradibus, is chiefly
based on that of _Ibn-al-Djazzâr_, who died about A.D. 1004.

See pages 130. 211. 377. 494. 573. 584. 600.

=Conti=, Niccolò dei. A Venetian merchant, who spent 25 years (from
1419 to 1444?) in India. His interesting accounts are by far the most
valuable of that period. They have been published for the Hakluyt
Society (ed. by Major): India in the 15th century, Lond., 1857, 39 pp.
A still more valuable edition and translation is due to Kunstmann:
Kenntniss Indiens im 15ᵗᵉⁿ Jahrhunderte. München, 1863. 66 pp.

See pages 282. 521. 577. 582. 636.

=Cordus=, Valerius. Born A.D. 1515 at Erfurt, professor of materia
medica in the University of Wittenberg, then the most eminent man
in that science. After his premature death, at Rome, in 1544, his
works were published by _Conrad Gesner_, in a large volume printed in
1561 at Strassburg. It contains: (1) Valerii Cordi _Annotationes_ in
Dioscoridem; (2) _Historiæ stirpium_ libri iv.; (3) De artificiosis
_Extractionibus_, and several other papers of V. Cordus, besides the
most remarkable book, _De Hortis Germaniæ_, by _Conrad Gesner_ himself.
A very careful biographic notice on _Cordus_ is due to Irmisch, Einige
Botaniker des 16 Jahrhunderts ... Sondershausen, 1862. 4°. pp. 1-34.

See pages 31. 148. 170. 248. 260. 429. 526. 580. 644. 648. 650. 661.
713. 733. 737.

=Cosmas=—See =Kosmas=.

=Crescenzi=, Piero de’, 1235-1320. He wrote, about A.D. 1304-1306, at
Bologna, an esteemed book on agriculture, which was repeatedly printed
towards the end of the 15th century, for instance, Opus _ruralium
commodorum_ Petri de Crescentiis, Argentine, 1486. There are numerous
later translations and editions.

See pages 6. 157. 180. 661.

=Dale=, Samuel, a physician in London, 1659-1739. _Pharmacologia_ seu
manuductio ad Materiam medicam. Lond., 1693, 12mo.

See pages 592. 615. 616. 648. 681. 731.

=Dioscorides=, Pedanios, of Anazarba, in Cilicia, Asia Minor. He
wrote, about A.D. 77 or 78, his great work on materia medica, the most
valuable source of information on the botany of the ancients.

See pages 6. 35. 43. 92. 97. 147. 161. 166. 172. 175. 179. 183. 234.
262. 276. 291. 292. 305. 310. 321. 325. 328. 331. 377. 384. 388. 434.
439. 464. 486. 493. 503. 519. 529. 556. 558. 567. 568. 581. 594. 609.
627. 638. 644. 655. 661. 664. 672. 675. 677. 680. 690. 699. 715. 723.
728. 729. 733.

=Dodonæus=, Rembert Dodoens, 1517-1585, physician at Malines, Belgium.

See pages 303. 388. 439. 699. 729. 731.

=Edrisi=, or Alidrisi, an Arab nobleman, born about A.D. 1099 in Spain,
living at King Roger’s court, Palermo, where he compiled, in 1153, his
remarkable geographical work. It summarizes all the earlier geographic
literature of the Arabs, adding much valuable information gathered by
the author from merchants and other travellers.—_Géographie_ d’Edrisi,
traduite en français, par P. Amedée Jaubert, 2 vols. Paris, 1836-1840.
_Description_ de l’Afrique et de l’Espagne, trad. par Dozy. Leyde, 1866.

See pages 115. 305. 316. 494. 503. 577. 584. 642. 644. 680.

=Fernandez=, latinized =Ferrandus=. Born at Madrid 1478. From 1514
to 1525 he was “veedor de las fundiciones do oro de Tierra-firma
in America,” _i.e._ superintendent of the foundries of gold in the
American continent; died 1537 in Valladolid. _Historia general y
natural de las Indias_ islas y tierra firme del mar oceano por el
Capitan _Gonzalo Fernandez de Oviedo y Valdés_, primer chronista del
nuevo mundo. Publ. dal codice orig. y illustr. p. J. _Amador de los
Rios_. This complete edition has been published in 4 vols., from 1853
to 1855, by the Academy of Madrid. We have not seen the earlier partial
editions, viz. “_Summario_ de la natural y general Historia de las
Indias,” Toledo, 1526, fol., “_Primera parte_ de la Historia natural
y general de las Indias,” Sevilla, por _Cromberger_, 1535, fol.; nor
“Cronica de las Indias,” 1547. See also Colmeiro, La Botanica y los
Botánicos de la peninsula Hispano-Lusitana, Madrid, 1858, 26, No. 220
(_Fernandez_) and 149; also _Haller_, Bibl. botanica, i. 272, who calls
him _Gundisalvus_ or _Gonsalvus Hernandez_. He is also quoted by others
as _Oviedo_.

See pages 95. 101. 186. 213. 453. 466. 534.

=Fuchs=, Leonhard, 1501-1566, Professor of medicine in the University
of Tübingen from 1535 to 1566, author of De _historia stirpium_
commentarii insignes.... Basileæ, 1542, fol., a work equally remarkable
for the excellent woodcuts and the careful descriptions.

See pages 170. 429. 453. 456. 469. 652.

=Galenos=, Claudius Galenus Pergamenus, A.D. 131-200, a most
distinguished medical writer, imperial physician at Rome. Many drugs
and officinal plants are mentioned in his numerous works, which were
held in the highest reputation during the middle ages.

See pages 35. 222. 268. 503. 519. 559. 609.

=Garcia=—See =Orta=.

=Gerarde=, John, 1545-1607, London, surgeon.—The _Herball_, or generall
historie of plantes, 1597.

See pages 31. 71. 170. 218. 254. 268. 453. 459. 480. 486. 487. 537.
552. 568. 589. 611. 655. 661. 694. 700. 729.

=Gesner=, Conrad, 1516-1565, Zürich, the most learned naturalist of his
time (See also Cordus).

See pages 299. 384. 390. 439. 456.

=Helvetius=, Jean-Claude-Adrien, 1661-1727, physician at Paris.

See pages 26. 371.

=Hernandez=, Francisco, physician to King Philip II. of Spain; he lived
about the years 1561-1577 in Mexico.—Quatro libros de la naturaleza y
virtutes de las plantas y animales que estan recevidos en el uso de
medicina en la Nueva España.... Mexico, 1615.—We have only referred to
Antonio Reccho’s translation: Nova plantarum, animalium et mineralium
Mexicanorum Historia, rerum medicarum Novæ Hispaniæ _Thesaurus_. Romæ,
1651, fol. (first edition, 1628). Hernandez must not be confounded with
_G. Fernandez de Oviedo_ (See _Fernandez_).

See pages 202. 206. 657.

=Hildegardis=, 1099-1179, the abbess of the Benedictine monastery St.
Ruprechtsberg, near Bingen (“Pinguia”) on the Rhine. Her “_Physica_”
one of the most interesting mediæval works of its kind, is contained
in tom. cxcvii. (1855) 1117-1352 of _J. P. Migne’s Patrologiæ cursus
completus_, under the name “Subtilitatum diversarum naturarum
creaturarum.... Liber i. De Plantis.

See pages 305. 378. 476. 512. 551. 584.

=Ibn Baitar=—See =Baitar=.

=Ibn Batuta=—See =Batuta=.

=Ibn Khordadbah=—See =Khurdadbah=.

=Idrisi=—See =Edrisi=.

=Isaac Judæus=, or Abu Jaqûb Ishaq ..., an Egyptian Jew, living at
Kâirowan, in Northern Africa, as a physician to the prince of the
Aglabites; died about A.D. 932-941. See Choulant, _Bücherkunde für die
ältere Medicin_, 1841, 347; also Meyer, Geschichte der Botanik, iii.
170.

See pages 217. 225. 325. 377.

=Isidorus=, Hispalensis, Bishop of Sevilla, about A.D. 595-636, author
of a great cyclopœdia, _Etymologiarum_ libri xx. We have referred to it
in “Sancti Isidori Opera omnia,” in the vol. lxxxii. (1859) of J. P.
Migne’s Patrologiæ cursus completus.

See pages 305. 380. 493. 529. 664.

=Istachri=, Abu Ishaq Alfarsi Alistachri (_i.e._ of Istachr, the
ancient Persepolis, in the Persian province Fars). His geographical
work has been translated (in the Transactions of the Academy of Ham)
by Mordtmann: Das _Buch der Länder_ von Schech Ebn Ishak el Farsi el
Isztachri. Hamburg, 1845.

See pages 316. 414. 716.

=Kamel= (or =Camellus=), George Joseph, born at Brünn, Moravia, A.D.
1661, a member of the company of Jesus A.D. 1682. By permission of
his superiors, he left in 1688 for the Marianne islands and the
Philippines. After having acquired a certain knowledge of botany and
pharmacy, he established, at Manila, a pharmaceutical shop with the
view of supplying medicaments gratis to the poor; he died there in
1706. Kamel communicated his botanical investigations to _Ray_ and
_Petiver_ (see R.); consult also A. de _Backer_, Bibliothèque des
Ecrivains de la compagnie de Jésus, iv. (Liége, 1858) 89.

See pages 148. 432.

=Kämpfer=, Engelbert. Born in 1651 at Lemgo, Westphalia; travelled
as a physician in Persia (1683-1685), India, Java, Siam (1690),
Japan (1690-1692); graduated in 1694 at Leiden, and died in 1716 at
Lemgo. His work, _Amœnitatum_ exoticarum fasciculi v., Lemgo, 1712,
was intended as a specimen of more elaborate accounts of the various
observations of the well-informed and zealous author. But only a
_History and description of Japan_ was published in German in 1777, by
Dohm at Lemgo. Kämpfer’s unpublished manuscripts and collections were
purchased, in 1753, by Sir Hans Sloane, for the British Museum.

See pages 20. 44. 167. 263. 272. 315. 512. 513. 527.

=Kazwini=, an Arabic geographer of the 13th century.—Ethé, Kazwini’s
_Kosmographie_. Leipzig, 1869.

See pages 503. 521. 573.

=Khurdadbah= or Ibn-Chordadbeh, engaged, towards the end of the 9th
century, in the police and postal administration of Mesopotamia, and
collecting informations about the products and tributes of the empire
of the Khalifes. They are translated by Barbier du Meynard: Le _livre
des routes et des provinces_, par Ibn Khordadbeh. Journal asiatique, v.
(1865) 227-296 and 446-527.

See pages 282. 512. 518. 573. 577. 642.

=Kosmas Alexandrinos Indikopleustes=, a Greek merchant, a friend
of Alexander Trallianus (p. 752), living in Egypt, travelling in
India, and lastly, towards the middle of the 6th century, a monk. His
monstrous work, _Christiana topographia_, contains, nevertheless, a
small amount of valuable information. We referred to it as contained in
Migne’s Patrologiæ cursus completus, series græca, t. lxxxviii. (1850)
374.

See pages 281. 577. 599.

=Lefebvre= or Le Fèbre, Nicolas, 16..-1674, Paris (partly also
London), “Apoticaire ordinaire du Roy, distillateur chymique de sa
Majesté”—_Traité de la Chymie_, Paris, i. (1660) 375-377.

See pages 65. 381.

=Liber pontificalis= seu de gestis Romanorum pontificum. Romæ, 1724
(edition of _Vignolius_). A new edition will be brought out in the
Monumenta Germaniæ.

See pages 137. 142. 281.

=Macer Floridus=, wrote, A.D. 1140, the book _De viribus herbarum_.
The editio princeps was printed A.D. 1487 in Naples; the best edition
is that of Choulant, Leipzig, 1832 (140 pages). Nothing exact is known
about that author himself.

See pages 627. 642. 684.

=Marcellus Empiricus=, a high functionary of the two emperors
Theodosius, towards the end of the 4th and in the beginning of the 5th
centuries.—De _medicamentis_ empiricis, physicis ac rationalibus liber.
Basileæ, 1536.

See pages 183. 729.

=Marcgraf=, Georg, 1610-1644, astronomer and geographer to Count Johann
Moriz von Nassau. See Piso.

See pages 187. 211. 228. 371.

=Masudi=, or Almasudi, Maçoudi A.D. 900-958. Born at Bagdad, travelled
in Arabia, India, and in the East of Africa. One of the distinguished
geographic writers of the Arabs. His works are being published by the
Société asiatique of Paris: _Les Prairies d’Or_, texte et traduction
par Barbier de Meynard et Pavet de Courteille, 8 vols., 1869-1873 (in
continuation).

See pages 503. 573. 584. 600. 680.

=Mattioli=, Pierandrea. Born in 1501 at Siena; living as a physician
at Trento, Görz, Prag; died A.D. 1577. There are many editions of his
chief work, _Commentarii_ in sex libros Pedacii Dioscoridis Anazarbei
de medica materia. The first, in Italian, was published in 1544 at
Venice.

See pages 32. 147. 183. 390. 439. 456. 609. 650.

=Meddygon Myddvai=—See =Physicians=.

=Mesuë=, the younger. Jahjâ ben Mâsaweih ben Ahmed.... Born at Maredin,
Kurdistan, physician to the Khalif Alhakem at Cairo; died A.D. 1015.

See pages 40. 225. 493.

=Monardes=, Nicolás, 1493-1588, physician at Sevilla.—Historia
medicinal de las cosas que se traen de nuestras Indias occidentales,
que sirven en medicina. Sevilla, 1569. Latin edition by Clusius, _De
simplicibus medicamentis_ ex occidentali India delatis, quorum in
medicina usus est. Antwerp. 1574. See Hanbury’s appreciation of the
book: Pharm. Journ. i. (1870) 298.

See pages 148. 202. 206. 443. 466. 534. 537. 697. 705.

=Mutis=, José Celestino, 1732-1808; 1760, physician to the viceroy of
New Granada; 1782, in charge of an “expedicion real botanica” of that
country. See Triana’s work, quoted at page 369. Triana much reduces,
apparently with good reason, the merits of Mutis, which would appear to
have been overrated by Humboldt.

See pages 106. 345.

=Nikandros Kolophonios=, of Klaros, near Kolophon in Ionia, in the 2nd
century B.C. Physician and poet.

See page 6.

=Nostredame=, Michel de. Born 1503 at Saint-Remi, Provence. Physician
and astrologer at Aix and Lyons; died A.D. 1566 at Salon, Provence.

See page 405.

=Oribasios Pergamenos=, a friend and physician to the emperor Julianus
Apostata, 4th century. We referred chiefly to _Bussemaker_ et
_Daremberg_, Oeuvres complètes d’_Oribasius_, 6 vols., 1851-1876.

See pages 35. 129. 175. 183. 222. 559. 729.

=Orta=, Garcia de, or Garcia ab Horto. (Years of birth and death
unknown.) He was a student of medicine and natural sciences in the
Universities of Salamanca and Alcalá, and a teacher and physician in
the University of Coimbra (or Lissabon?). In 1534 Garcia accompanied
Martim Affonso de Souza, grand admiral of the Indian fleet, to Goa, and
lived there as a royal physician (Physico d’El Rey) to the hospital.
Garcia appears to have been still living there in 1562, when he
obtained the vice-regal privilege for his book “_Coloquios_ dos simples
e drogas he cousas mediçinais da India, e assi dalguãs frutas achadas
nella ande se tratam.... Impresso em Goa, por Joannes de endem as x
de Abril de 1563,” 436 pp., 4°. (British Museum).—F. A. von Varnhagen
has caused the Coloquios to be reprinted in 1872 at Lisbon. Garcia
de Orta’s Coloquios are, notwithstanding the utterly diffused style
of the work, a precious source of information on eastern drugs. They
had the good chance to be translated, as early as the year 1567, by
Clusius, who omitted the insignificant parts of the book, re-arranged
it conveniently, and added valuable notes. See Flückiger in Buchner’s
Repertorium für Pharmacie, xxv. (1876) 63-69.

See pages 43. 86. 130. 154. 200. 225. 241. 272. 405. 415. 429. 462.
512. 521. 527. 547. 585. 638. 644. 712.

=Oviedo=, Capitan Gonzalo Fernandez de Oviedo y Valdés—See =Fernandez=.

=Palladius=, Rutilius Taurus Aemilianus, an agricultural author of the
4th or 5th century of our era, living probably in northern Italy. We
have chiefly referred to _Nisard’s_ edition of the fourteen books of
Palladius “_De re rustica_,” which is contained in Firmin Didot’s “Les
Agronomes latins,” Paris, 1877.

See page 328.

=Parkinson=, John, 1567-1629 (?), an apothecary of London, and director
of the Royal Gardens at Hampton Court. _Theatrum botanicum_, or an
herball of large extent.... London, 1640. fol.

See pages 84. 189. 287. 429. 469. 470. 500. 556. 589. 616. 623. 648.
698. 731.

=Paulus Ægineta= (Paulos Aiginetes), a physician of the first half of
the 7th century of our era, who appears to have lived for some time
at Alexandria. Author of “seven books” on medicine, which have been
first published, in Greek, in 1528 at Venice, and, in Latin, in 1532
at Paris, translated by Winter (Guinterus) of Andernach: _Compendii_
medici libri septem. We have also referred to the translation of Adams.

See pages 3. 35. 175. 183. 271. 281. 559. 563.

=Pavon=, José, a Spanish botanist, who explored in common with Ruiz
the flora of Peru. Biographic particulars about Pavon are wanting
even in Colmeiro’s La botánica y los botánicos de la peninsula
Hispano-Lusitana, Madrid, 1858. 181.

See pages 345. 590.

=Paxi= or =Pasi=, Bartolomeo di; the author of a curious book giving
practical information about the weights and measures in use in various
countries. There are many editions, the first of which, as examined in
1876 by one of us (F. A. F..) in the library of San Marco, Venice, is
found to bear the following title:—“Qui comincia la utilissima opera
chiamata _Taripha_, la qvol tracta de ogni sorte de pexi e misure
conrispondenti per tuto il mondo fata e composta per lo excelente e
eximio Miser Bartholomeo di _Paxi_ da Venezia. Stampado in uenezia
per Albertin da lisona uercellese regnante l inclyto principe miser
Leonardo Loredano. Anno domini 1503. A di 26 del mese de luio.”

See pages 235. 609.

=Peres=—See =Pires=.

=Periplus Maris Erythræi=, a survey of the Red Sea and the Indian Ocean
as far as the coast of Malabar. In his interesting account, written
about between A.D. 54 and 68, the author, commonly called Arrian
of Alexandria, gives a list of imports and exports of the various
places which he had visited or of which he had good informations. See
_Vincent_, Commerce and Navigation of the Ancients, etc. London, vol.
i. (1800), ii. (1805); also C. _Müller_, Geographi græci minores, i.
(Paris, 1855) 257-305. Anonymi (_Arriani_ ut fertur) Periplus maris
erythræi.

See pages 35. 142. 272. 493. 520. 529. 577. 599. 664. 675. 680. 715.

=Physicians of Myddvai= (Meddygon Myddfai). Rhys Gryg (_i.e._ the
Hoarse), prince of South Wales (died in 1233 at Llandeilo Vawr), had
his domestic physician, namely Rhiwallon, who was assisted by his
three sons Cadwgan, Gruffydd, Einion, from a place called Myddvai, in
the present county of Caermarthen. They made a collection of recipes,
the original manuscript of which is in the British Museum. Another
collection has been compiled, from the original sources, by Howel the
Physician, son of Rhys, son of Llewelyn, son of Philip the Physician,
a lineal descendant of Einion, the son of Rhiwallon. Both these
compilations have been published at Llandovery in 1861, together with a
translation, by John Pughe, under the above title (470 pp.)

See pages 6. 40. 65. 71. 141. 157. 161. 170. 180. 299. 305. 310. 316.
334. 380. 383. 393. 401. 450. 464. 469. 476. 488. 556. 625. 635. 642.
652.

=Pires=, Tomé (or Pyres, Pirez, as he also writes his name himself),
a Portuguese apothecary. He was the first ambassador sent, probably
in 1511, from Europe, or at least from Portugal, to China. Pires
addressed, in 1512-1516, several letters from Cochin and Malacca to
the Admiral Affonso d’Albuquerque and to King Manuel of Portugal.
One of them, written January 27, 1516, from Cochin to the King,
enumerates many drugs which were to be met with in that place—“dando
l-lhe noticias das drogas da India,” says the writer. This letter,
still existing in the Real y Nacional Archivo da Torre do Tombo (corpo
chronologico, part i. fasc. 19, No. 102), was communicated in 1838 by
Bishop Condo Don Francisco de San Luiz to the Portuguese Pharmaceutical
Society, and published in their “Jornal de Socied. Pharm. Lusit.
ii. (1838) 36.” It will also be found in the pamphlet[2785] “Elogio
historico e noticia completa de Thomé Pires, pharmaceutico e primeiro
naturalista da India; e o primeiro embaixador europeo a China. Memoria
publicada na Gazeta de Pharmacia por Pedro José da Silva.” ...
Lisboa, 1866. 47 pp. (“y 22 fac simile de sua signatura”). We had,
moreover, before us an authentic copy of the letter under notice,
obligingly written 1st December, 1869, for one of us by Senhor
Joaquim Urbano de Veiga, the Secretary of the Sociedad Pharmaceutica
Lusitana. According to _Colmeiro_, La Botánica y los Botánicos de la
Peninsula Hispano-Lusitana, Madrid, 1858. 148, Peres was attached to
the factory of Malacca as a “scribano” (secretary?) and “por tener
conocimientos farmacéuticos,” and was sent to China, with the character
of an ambassador, in order to examine more freely the plants. He was
imprisoned, says Colmeiro, at Pekin, and there died soon after 1521
in prison. Yet _Abel Rémusat_, in the 34th volume of the “Biographie
universelle” (1823), p. 498, and also in his “Nouveaux mélanges
asiatiques” ii. (1828) 203, states that Pires proceeded first to
Canton, and reached Pekin in 1521. From this place he was sent to
Canton and imprisoned for many years from political causes. He was
still living in 1543.

See pages 43. 255. 681.

[2785] Library of the Pharm. Soc. of Great Britain, London, among the
“Pamphlets. No. 30” (Sept. 1878).

=Piso=, Willem. The Dutch, having conquered in 1630 from the Spanish
the north-eastern part of the Brazilian coast, between Natal and Porto
Calvo, Count _Johann Moriz von Nassau-Siegen_ was appointed, in 1636,
Governor-General of these possessions. He left them in 1644; the
history of his reign is contained in the work of _Barlæus_, Rerum per
Octoennium ... gestarum ... historia, Amstelodami, 1647. The Count had
also instituted a scientific exploration of the environs of Pernambuco
(or Recife), his residence, by his physician _Piso_ and _Marcgraf_, the
friend of the latter (see M.), who lived also at the Count’s court.
They devoted several years (from 1638 to 1641) zealously to their
task. The results of their investigations are found in—(1) Historia
naturalis Brasiliæ, published by Joh. de Laet, Lugd. Bat., 1643. (2)
Pisonis de _medicina brasiliensi_ libri iv., et G. Marcgravii _historiæ
rerum naturalium Brasiliæ_ libri viii. Lugd. Bat., 1648. (3) Pisonis de
_utriusque Indiæ historia naturali_ et _medica_ libri xiv. Amstelodami,
1658.

See pages 27. 113. 114. 130. 152. 211. 228. 371. 591.

=Platearius, Matthæus=, one of the most distinguished writers of
the famous medical school of Salerno, about the middle of the 12th
century. He compiled the remarkable dictionary of drugs, “Liber de
simplici medicina,” which was extremely appreciated during the next
centuries, and even reprinted as late as the beginning of the 17th
century. The work begins with a definition of the signification of the
term Simplex medicina; it is in these words: _Circa instans_ negotium
de simplicibus medicinis nostrum versatur propositum. Simplex autem
medicina est, quæ talis est, qualis a natura producitur: ut gariofilus,
nux muscata et similia.... The work of Platearius is therefore usually
quoted under the name _Circa instans_. The list of the 273 drugs
enumerated in “Circa instans” will be found in Choulant (_l.c._ at
p. 751), p. 298. We have referred to “Circa instans” as contained in
the volumes—Dispensarium magistri Nicolai præpositi ad aromatarios,
Lugduni, 1517, or Practica Jo. Serapionis, Lugd. 1525.

See pages 225. 316. 581.

_Plinius_ (Cajus Plinius Secundus), A.D. 23-79, the well-known author
of the “_Naturalis historiæ_ libri xxxvii.” We have particularly used
_Littré’s_ translation, “Histoire naturelle de Pline,” published in 2
vols. by Firmin Didot, Paris, 1877.

See pages 6. 35. 43. 97. 147. 161. 179. 234. 276. 281. 291. 305. 310.
325. 329. 333. 377. 434. 439. 474. 486. 488. 493. 503. 519. 529. 543.
556. 558. 576. 595. 609. 627. 644. 661. 664. 672. 677. 680. 729. 733.

=Plukenet=, Leonard, 1642-1706, physician, director of the Royal
gardens, London; collector of a large herbarium still existing in the
British Museum.

See page 16.

=Polo=, Marco, a noble Venetian, the most famous among mediæval
travellers. He spent 25 years, from 1271 to 1295, in Asia, chiefly in
China. The account of his travels was written, in French, in 1298, by
_Rusticiano_ of Pisa, and published since in numerous translations and
abstracts. We have chiefly referred to the two following excellent
works: (1) _Pauthier._ Le livre de _Marco Polo_, publié pour la
première fois d’après trois manuscrits inédits de la Bibliothèque
impériale de Paris, 1865. (2) _Yule._ The book of Ser Marco Polo the
Venetian, concerning the kingdom and marvels of the East, with notes
and illustrations. 2 vols. London, 1871, second edition 1874.

See pages 200. 282. 494. 510. 512. 520. 584. 636. 717.

=Pomet=, Pierre, “marchand épicier et droguiste à Paris, rue des
Lombards, à la Barbe d’Or.”—Histoire générale des drogues, 1694, fol.
528 pages, 400 engravings. There are later editions in 2 vols., 4°;
that of 1735 by the author’s son, an “apotiquaire” at St. Denis. See
_Hanbury’s_ appreciation of the book, Pharm. Journ. i. (1870) 298.

See pages 21. 26. 73. 118. 126. 148. 260. 263. 479. 617. 623. 648. 657.

=Porta=, Giovanni Battista, 1539(?)-1615, a distinguished Napolitan
nobleman. Of his remarkable works we have before us—_De distillatione_,
lib. ix. Romæ 1608, 154 pp. It is partly contained also in Porta’s
Magiæ naturalis libri xx, 1589, yet not in the earlier editions of the
Magia, the first of which appeared in 1558. Another work of the same
author, the _Phytognomica_, Naples, 1583, may be mentioned as one of
the chief works treating on the “Doctrine of Signatures.” There are
several editions of it, usually containing the curious figures of the
tubers of orchids as especially connected with that superstitious
doctrine.

See pages 118. 263. 385. 479. 526. 580. 653. 655.

=Præpositus=, Nicolaus, one of the eminent physicians of the school of
Salerno (see S.) living in the first half of the 12th century. He gives
in his _Antidotarium_, first edition, Venetiis 1471, the composition of
about 150 medicines, which were much used, under his name, during the
following centuries. They are enumerated in Choulant’s book, mentioned
p. 751 before.

=Pun-tsao=, a great Chinese herbal, written by _Le-she-chin_, in the
middle of the 16th century. It consists of 40 thin octavo volumes,
the first three of which contain about 1,100 woodcuts. For more exact
information consult _Hanbury_, Science Papers, 212 et seq.

See pages 4. 76. 83. 167. 510. 520.

=Ramusio=, Giovanni Battista.—Terza editione delle navigationi e viaggi
raccolti già da G. B. Ramusio, 3 vol. fol. Venetia, 1554. A valuable
collection of accounts of mediæval travellers, chiefly Italian.

See page 4.

=Ray= (Wray, or Rajus) John, 1628-1705, a clergyman and distinguished
botanist. His Herbarium is preserved in the British Museum. Historia
plantarum, 3 vols., folio, London, 1686-1704.

See pages 254. 277. 481. 482. 615. 731. 740.

=Redi=, Francesco, a physician of Arezzo, who lived at Florence.
_Esperienze_ intorno a diverse cose naturali e particularmente a quelle
che ci son portate dell’ India. Firenze, 1671.

See pages 24. 111. 287.

=Rhazes= (Abu Bekr Muhammad ben Zakhariah Alrazi) from Raj, in the
Persian province Chorassan, where he was a physician to the hospital
and subsequently at Bagdad; died A.D. 923 or 932.

See pages 3. 271. 393. 642. 716.

=Rheede= tot Draakestein, Hendrik Adriaan van, 1636-1691, Dutch
governor of Malabar. He ordered the most conspicuous plants of India
to be figured and to be described, mostly by Jan Commelin, professor
of botany at Amsterdam. This great and valuable work is the _Hortus
indicus malabaricus_, 12 vols. folio, Amstelodami 1678-1703, with 794
plates.

See pages 130. 189. 211. 297. 403. 421. 425. 547. 565. 580. 644. 677.
726.

=Ricettario Fiorentino=; one of the earliest, if not the very first,
printed Pharmacopœia published by authority. It bears title: Ricettario
di dottori dell’ arte, e di medicina del collegio Fiorentino all’
instantia delli Signori Consoli della universita delli speciali.
Firenze, 1498. Folio. We have referred to the edition of 1567, printed
at “Fiorenza, Nella Stamperia dei Giunti 1574.” There are other
editions of that Florentine Pharmacopœia down to the year 1696.

See pages 40. 410. 706.

=Roteiro.= The account of the famous expedition of _Vasco da Gama_ to
the Cape (22nd November, 1497), due to one of his companions, _Alvaro
Velho_. The author enumerates in his remarkable pamphlet (see title at
page 496) several spices and drugs of India, stating their prices there
and in Alexandria. See also _Heyd_, Geschichte des Levantehandels, ii.
(1879) 507.

See pages 404. 496.

=Ruel=, or =Ruellius=, also =de la Rouelle=, Jean. 1474-1537. Physician
at Soissons, lastly canon at Paris. De natura stirpium libri iii.
Parisiis, 1536. Folio. (See also _Scribonius Largus_.)

See pages 31. 388.

=Ruiz=, Hipolito. 1754-1816. A Spanish botanist, in 1777 appointed
director of the celebrated exploration of Peru and Chile. (See also
Pavon.)

See pages 79. 345. 590.

=Rumphius= (Rumpf), Georg Eberhard, 1627-1702. Dutch governor of
Amboina. He figured and described 715 plants of that island in the
Herbarium amboinense, 7 vols., Amstelodami, 1741-1755, folio, 696
plates.

See pages 130. 189. 211. 278. 297. 336. 421. 565. 600. 673. 726. 749.

=Saladinus=, of Ascoli (probably Ascoli di Satiano in the Capitanata,
Apulia), physician to one of the Princes of Tarentum (and apparently
also to the grand constable of Naples, Prince Giovanni Antonio de Balzo
Ursino). He is the author of the “_Compendium aromatariorum_ Saladini,
principis tarenti dignissimi medici, diligenter correctum et emendatum.
Impressum in almo studio Bononiensi, 1488;” 4°. 58 pages. Further on,
the author calls himself Dominus Saladinus de Esculo, Serenitatis
Principis Tarenti phisicus principalis. At the end of his pamphlet he
gives the list of drugs “communiter necessariis et usitatis in qualibet
_aromataria_ vel _apotheca_.” ... This book intended for the druggists,
_aromatarii_, was written between A.D. 1442 and 1458, as shown by
Hanbury, Science Papers, 358.

See pages 148. 183. 225. 377. 388. 456. 582. 585. 600.

=Salerno=, the school of medicine. During the middle ages, from about
the 9th century, there were flourishing in the said Italian town a
large number of distinguished medical practitioners and teachers. It is
one of their merits to have transmitted the medical art and knowledge
of the Arabs to mediæval Europe.—See also _Alphita_, _Constantinus
Africanus_, _Platearius_, _Nicolaus Præpositus_. That once famous
institution continued an obscure existence even down to the year 1811,
when it was suppressed, November 29th, by order of Napoleon.—See pages
31. 225. 321. 334. 377. 690.

=Sanudo=, Marino, a well informed Venetian writer, author of (1) Vite
de _duchi_ di _Venezia_, in Muratori, Scriptores rerum italicarum xxii.
(Mediolani, 1733) 954 et seq. (2) _Marinus Sanutus_ dictus Torsellus
Patricius Venetus, _Liber Secretorum_ fidelium crucis super terræ
sanctæ recuperatione et conservatione, in Orientalis Historiæ, tom ii.
(Hanoviæ, 1611) 22; lib. i. part i. cap. 1. The latter work contains,
at page 23, a classified list of eastern drugs; among the most valuable
spices, Sanudo mentions cloves, cubebs, mace, nutmegs, spikenard; among
those less costly, cinnamon, ginger, olibanum, pepper.

See pages 245. 636.

=Scribonius Largus=, a Roman physician of the first century of our era.
He accompanied, in A.D. 43, the emperor Claudius when he attempted the
definite conquest of the island of Britain. Scribonius is the author
of the valuable book, _Compositiones Medicamentorum_ seu Compositiones
medicæ, the earliest edition of which is due to Ruel, Paris, 1529.

See pages 6. 35. 42. 147. 179. 219. 245. 331. 493. 503.

=Simon Januensis=—See pages 6. 44. 582. 652.

=Sloane=, Sir Hans, 1660-1753. In 1687 physician to the governor of
Barbados and Jamaica. His library and large collections of natural
history formed the nucleus of the British Museum. He wrote (1)
_Catalogus_ plantarum quæ in insula Jamaica sponte proveniunt vel vulgo
coluntur ... adjectis aliis quibusdam, quæ in insulis Maderæ, Barbados,
Nieves et St. Christophori nascuntur, Londini, 1696. (2) A _voyage_ to
the islands Madera, Barbados, Nieves, St. Christophers and Jamaica.
London, 1707-1725, fol.

See pages 18. 73. 188. 203. 288. 591. 615. 629. 710.

=Susruta.= The author of “_Ayurvedas_,” _i.e._ the book of health,
an old Sanskrit medical work in which a large number of eastern
drugs are mentioned. It was first printed in the original language
at Calcutta, 2 vols., 1835-1836, and afterwards translated under
the name _Susrutas Ayurvedas_, id est medicinæ systema a venerabili
_D’hanvantare_ demonstratum, a Susruta discipulo compositum. Nunc
primum ex Sanskrita in Latinum sermonem vertit.... Fr. Hessler,
Erlangæ, 3 vols., 1844-1850. And by the same translator, Commentarii et
annotationes in Susrutæ ayurvedam, 1852-1855. Susruta was once supposed
to have written centuries before Christ, but chiefly the researches of
Prof. Haas, London, in the _Zeitschrift der Deutschen Morgenländischen
Gesellschaft_, xxx. (1876) 617 _sqq._ and xxxi. (1877) 647, make it not
improbable that the Sanskrit “Susruta” might have been generated from
the Greek Hippokrates by way of the intermediate form “Bukrat.” The
oldest testimony as to the time of Susruta (and Charaka, see before) is
the statement of Ibn Abu Oseibiah, in the 13th century, that Susruta
had been translated into Arabic about the end of the 8th century.

See pages 154. 188. 211. 225. 295. 315. 421. 425. 436. 503. 547. 572.
644.

=Tabernæmontanus=, Jacob Theodor, physician at Heidelberg; died A.D.
1590. A pupil of Tragus.—Neuw Kreuterbuch, Frankfurt, 1588, folio;
second part, 1591, both with fig. Later editions, also in German,
by Caspar Bauhin and Hieronymus Bauhin. Latin translation, Eicones
plantarum seu stirpium ... Francofurti, 1590, with 2225 engravings.

See pages 308. 390. 731.

=Talbor=, or also =Tabor=, Robert, 1642-1681. This singular personage
having been apprenticed to Dear, an apothecary of Cambridge, settled
in Essex, where he practised medicine with much success. He afterwards
came to London, and in 1672 published a small book called Πυρετολογία,
_a rational account of the cause and cure of agues_ (London, 12°). As
stated at page 344, he was appointed physician to the king, and on 27th
July of the same year, received the honour of knighthood at Whitehall.
But he was not a member of the College of Physicians; and to save him
from attack, Charles II. caused a letter to be written restraining
that body from interfering with him in his medical practice. (Baker,
_l.c._ at page 344, note 1). The appointment as royal physician, made
in consideration of “good and acceptable services performed,” led
to the issuing of a patent under the Privy Seal, dated 7th August,
1678, granting to Sir Robert Talbor an annuity of £100 per annum,
together with the profits and privileges appertaining to a physician
in ordinary to the sovereign. In 1679 Talbor visited France and Spain,
as recorded in the _Recueil des nouvelles_ etc. pendant l’année 1679
(Paris, 1780) 466 (this includes the _Gazette de France_, 23rd Sept.,
1679). The journey to Spain he made in the suite of the young queen of
Spain, Louise d’Orléans, niece of Louis XIV., of whom he is described
as _premier médecin_. During Talbor’s absence, his practice in London
was carried on by his brother, Dr. John Talbor, as is proved by an
advertisement in the _True News_ or _Mercurius Anglicus_, January
7-10, 1679. In France Talbor had the good fortune to cure the Dauphin
of an attack of fever, and also treated with success other eminent
persons. (See _Lettres de Madame de Sévigné_, nouv. ed. tome v., 1862,
559; also tome vi., letters of 15th and 29th Sept, and 6th Oct. 1679.)
The physicians both in England and France were exceedingly jealous of
the successes of an irregular practitioner like Talbor, and averse to
admit the merits of his practice. Yet D’Aquin, first physician to Louis
XIV., prescribed _Vin de Quinquina_, as well as powdered bark, for the
king in 1686.—See J. A. Le Roi, J. _Journal de la santé du roi Louis
XIV._, Paris, 1862. 171. 431. But Talbor’s happy results brought him
into favour with Louis XIV., who induced him, in consideration of a sum
of 2,000 louis d’or and an annual pension of 2,000 livres, to explain
his mode of treatment, which proved to consist in the administration of
considerable doses of cinchona bark infused in wine, as will be seen
in the pamphlet: _Les admirables qualitez du Kinkina confirmées par
plusieurs expériences_, Paris, 1689. 12°. Talbor did not long enjoy his
prosperity, for he died in 1681, aged about 40 years. He was buried in
Trinity Church, Cambridge, where a monumental inscription describes
him as—“_Febrium malleus_” and physician to Charles II., Louis XIV,
and the Dauphin of France. In Talbor’s will, proved by his widow, Dame
Elizabeth Talbor, alias Tabor, relict and executrix, 18th Nov. 1861,
and preserved at Doctors’ Commons, mention is made of an only son,
Philip Louis.

See page 344.

=Theophrastos Eresios=, of Eresos, in the island of Lesbos, about
370-285 B.C. The earliest botanical author in Europe, having consigned
in his works, written about the year 314 B.C. or later, an admirable
amount of excellent observations, either of his own, or, as many
suggest, originated from Aristotle. Among the numerous editions of
Theophrast’s works (printed as early as A.D. 1483) we may point out
Wimmer’s Latin translations, tom. i. _Historia plantarum_, tom. ii. _De
Causis plantarum._ Leipzig, 1854; or the French edition of the same
translator, Théophraste, Oeuvres complètes. Paris, 1866, Firmin Didot.

See pages 42. 97. 136. 142. 146. 147. 161. 166. 175. 179. 234. 259.
292. 310. 321. 393. 418. 439. 519. 529. 567. 576. 595. 598. 620. 644.
661. 664. 677. 690. 715. 723. 733.

=Tournefort=, Joseph Pitton de, 1656-1708. Important as are his
attempts to establish a scientific classification of plants, his merits
as a careful observer (1700-1702) of eastern plants are of still more
weight from a pharmaceutical standpoint. The latter is evidenced by his
Relations d’un _voyage_ du Levant.... Paris, 1717, 2 vols.

See pages 163. 175.

=Tragus= (Bock), Hieronymus, 1498-1554. A friend and pupil of Brunfels
(see B.), protestant clergyman at Hornbach, near Zweibrücken, Bavarian
Palatinate. He gave remarkably good descriptions of the indigenous
plants, with figures, in his “_Kreuterbuch_,” the best edition of which
was published in German at Strassburg, A.D. 1551, and a translation in
1552: Hieronymi Tragi, de stirpium, maxime earum quæ in Germania nostra
nascuntur usitatis nomenclaturis, etc. libri très.

See pages 170. 295. 384. 388. 434. 450. 456. 469. 540. 665. 676. 694.
699. 731. 734.

=Turner=, William, born at Morpeth, Northumberland (date not known),
died 1568. In 1538 he was a student of theology and medicine in
Pembroke College, Cambridge. Turner lived many years in Germany, and
was an intimate friend of _Conrad Gesner_. The “New _Herball_, wherein
are contayned the names of herbes in Greeke, Latin, ... and in the
potecaries and herbaries ... with the properties etc., by William
Turner, London, 1551; the seconde parte, Collen (Cologne), 1562; the
third parte, London, 1568,” is the earliest scientific work on botany
in the English literature. To its author is also due the foundation of
the Kew Gardens.

See pages 292. 378. 480. 556. 568. 571. 729.

=Vasco da Gama=—See =Roteiro=.

=Vegetius Renatus.= A treatise on veterinary medicine, written
apparently about the beginning of the 5th century of our era, is
attributed to an author of the above name. See _Choulant_, p. 223 of
the work quoted before (p. 751).

See pages 175. 380.

=Vignolius=—See =Liber pontificalis=.

=Vindicianus=, physician to the Emperor _Valentinianus_ I., about A.D.
364-375. For further information see _Choulant’s_ work (quoted at p.
751), p. 215; also _Haller_, Bibl. bot. i. 151.

See page 559.




INDEX.


Natural Orders are printed in small capitals, as ACANTHACEÆ: headings
of articles in thick type, as =Ammoniacum=.

    Aāqarqarhā, 383
    Abelmoschus esculentus Guill. et Perrottet, 94
    Abies balsamea Marshall, 612
    ” canadensis Michaux, 612
    ” excelsa DC., 616
    ” pectinata DC., 615
    Abietic acid, 607. 608
    Abietite, 615
    Abilo, 147
    Abrus precatorius, 4. 188
    Abuta rufescens Aublet, 30
    Abutua, 26. 30
    Acacia abyssinica Hochst., 234
    ” Adansonii Guill. et Perr., 234
    ” arabica Willd., 234
    ” capensis Burch., 237
    ” Catechu Willd., 240
    ” dealbata Link, 237
    ” decurrens Willd., 237
    ” fistula Schweinfurth, 234
    ” glaucophylla Steudel, 234
    ” homalophylla Cunningh., 237
    ” horrida Willd., 237
    ” Karroo Hayne, 237
    ” lophantha Willd., 67
    ” mollissima Willd. 237
    ” nilotica Desfont., 234
    ” pycnantha Benth., 237
    ” Senegal Willdenow, 233
    ” Seyal Delile, 234. 237
    ” stenocarpa Hochstetter, 234
    ” Suma Kurz, 241
    ” Verek Guill. et Perrott., 232
    Acacien-Gummi, 233
    ACANTHACEÆ, 472
    Acer, sugar-yielding species, 721
    Aceite del palo, 229
    ” de Sassafras, 540
    Aconella, 11
    Aconine, 9
    Aconite, japanese, 10
    ” indian, 12
    ” leaves, 11
    ” Nepal, 12
    ” root, 8
    Aconitic acid, 11. 718
    Aconitine, 9
    Aconitum Anthora L., 10
    ”  Cammarum Jacq., 10
    ”  ferox Wall., 12
    ”  heterophyllum Wall., 14
    ”  japonicum Thunberg, 10
    ”  luridum Hkr. et Thoms., 12
    ”  Lycoctonum L., 10
    ”  Napellus L., 8
    ”  palmatum Don, 12
    ”  paniculatum Lam., 10
    ”  Störckeanum Reichenb., 10
    ”  uncinatum L., 12
    ”  variegatum L., 10
    Acore odorant, 676
    Acorin, 678
    Acorus Calamus L., 676
    Acrinyl sulphocyanate, 70
    Actæa racemosa L., 15
    ” spicata L., 3. 15
    Adragante, 174
    Adraganthin, 174. 178
    Ægle Marmelos Correa, 129
    Æsculin, 541
    Æthusa Cynapium L., 302
    Affium, 49
    Afyun, 43
    Agaricus Oreades Bolt., 251
    Agave americana L., 680
    Agi, 452
    Agropyrum acutum R. et S., 730
     ” junceum P. de Beauv., 730
     ” pungens R. et S., 730
     ” repens P. de Beauv., 729
    Ajowan or Ajvan, 302. 333
    Akulkara, 383
    Alantcamphor, 381
    Alantic acid, 381
    Alantol, 381
    Alantwurzel, 380
    Albizzia lophantha Benth., 67
    Aleurites cordata Müller Arg., 91
    Aleuron, 565
    Alga marina, 749
    Alga zeylanica, 749
    ALGÆ, 747
    Alhagi Camelorum Fischer, 414
    Allspice, 287
    Allyl cyanide, 66
     ” sulphocyanide, 66
    Almond, bitter, 247
     ”         ”   ess. oil of, 248
     ”-legumin, 247
     ” oil, 246
     ” sweet, 244
    =Aloë=, 679
    ” species yielding the drug, 679
    Aloes wood, 281
    Aloëresic acid, 689
    Aloëretic acid, 689
    Aloëretin, 689
    Aloes, 679
     ” Barbados, 685
     ” bitter of, 689
     ” Bombay, 684 ” Cape, 685
     ” Curaçao, 685
     ” East Indian, 684
     ” hepatic, 684
     ” Moka, 685
     ” Natal, 686
     ” resin of, 686
     ” Socotrine, 684
     ”     ”      liquid, 685
     ” Zanzibar, 684
    Aloëtic acid, 689
    Aloëtin, 689
    Aloïn, 687
    Aloïsol, 689
    Alorcinic acid, 689
    Alpinia Cardamomum Roxb., 643
      ”  Galanga Willd., 643
      ”  officinarum Hance, 641
    Alstonia scholaris R. Brown, 421
    Althæa officinalis L., 92
    Altingia excelsa Noronha, 272. 277
    Amandes amères, 247
      ” douces, 244
    Amantilla, 377
    Ammi copticum L., 302
     ” majus L., 304
    Amomis acris Berg, 289
    =Ammoniacum=, 324 ” African, 327
    Ammoniak-Gummiharz, 324
    Ammoniaque, gomme-résine, 324
    Amomum aromaticum Roxb., 650
     ” Cardamomum L., 648
     ” genuinum, 648
     ” Korarima, 650
     ” maximum Roxb., 650
     ” Melegueta Roscoe, 651
     ” rotundum, 648
     ” subulatum Roxb., 649
     ” verum, 648
     ” xanthioides Wallich, 649
     ” Zingiber L., 635
    AMPELIDEÆ, 159
    =Amygdalæ amaræ=, 247
     ” =dulces=, 244
    Amygdalin, 248
    Amygdalus communis, 244. 247
    =Amylum Marantæ=, 629
    Amyrin, 150
    Amyris elemifera Royle, 152
    ANACARDIACEÆ, 161
    Anacyclus officinarum Hayne, 384
     ” Pyrethrum DC., 383
    Anamirta Cocculus Wight et Arnott, 31
     ” paniculata Colebr., 31
    Anamirtic acid, 33
    Auanto-mul, 423
    Andrographis paniculata Wall., 438. 472
    Andropogon Calamus aromaticus Royle, 725
      ” citratus DC., 725
      ” laniger Desf., 728
      ” Martini Roxb., 725
      ” muricatus Retzius, 728
      ” Nardus L., 725
      ” pachnodes Trinius, 725
      ” Schœnanthus L., 267. 725. 728
    Anethol, 22. 309
    Anethum Fœniculum L., 308
      ” graveolens L., 327
      ” segetum L., 328
      ” Sowa Roxb., 328
    Angelic acid, 313. 386. 389. 391
    Angelic acid in Sumbul, 313
    Angelin, 81
    Angostura Bark, 106
    Angosturine, 107
    Anguzeh, 318
    Animi, 148. 152. 153
    Anis étoilé, 20
    Anise de Sibérie, 21
    Anise or Aniseed, 310
      ”-camphor, 22. 309
      ” Star-, 20
    Antamul, 427
    Anthemis nobilis L., 384
      ” Pyrethrum L., 383
    Anthophylli, 286
    Anthriscus vulgaris Persoon, 302
    Aphis chinensis, 168
      ” Pistaciæ, 598
    Aplotaxis auriculata DC., 382
     ” Lappa Decaisne, 382
    Apocodeine, 59
    APOCYNEÆ, 421
    Apomorphine, 59
    Aporetin, 499
    Aqua Aurantii florum, 126. 127
      ” Naphæ, 126. 127
    Aquilaria Agallocha Roxb., 681
    Arabic acid, 238
    Arabin, 238
    Arabisches Gummi, 233
    Arachic acid, 97. 187. 420
    Arachide, 186
    Arachis hypogæa L., 186
      ” oil, 186
    Arbol a brea, 147. 150
    Arbutin, 401
    Arbutus Uva-ursi, 401
    Arctostaphylos glauca Swindley, 402
      ” officinalis Wimmer et Grab., 401
      ” Uva-ursi Sprengel, 401
    Areca Catechu L., 669
      ” nut, 211. 512. 669
    Arekanüsse, 211. 512
    Arenga saccharifera Mart., 721
    Argel plant, 220
    Aricine, 359
    Arka, 425
    Aristolochia reticulata Nuttal, 593
      ” Serpentaria L., 592
    ARISTOLOCHIACEÆ, 591
    Armon, 71
    Armoracia, 71
    Arnica angustifolia Vahl, 390
      ” flowers, 392
      ” montana L., 390
      ” root, 390
    Arnicin, 391
    Arnicine, 391
    AROIDEÆ, 697
    Arrack, 721
    Arrowroot, 629
      ” East Indian, 634
    Artanthe adunca Miq., 591
      ” elongata Miq., 589
      ” lanceæfolia Miq., 591
      ” mollicoma Miq., 114
    Artanthic acid, 590
    Artemisia Cina Berg, 388
      ” Lercheana Karel. et Kirilow, 387
      ” maritima Ledebour, 387
    ARTOCARPACEÆ, 542
    Arundo Ampelodesmos Cirillo, 747
    Asa dulcis, 405
    =Asafœtida=, 314
    Asagræa officinalis Lindley, 697
    Asant, 314
    ASCLEPIADEÆ, 423
    Asclepias asthmatica Roxb., 427
      ” gigantea Willd., 424
      ” Pseudo-sarsa Roxb., 423
      ” Vincetoxicum L, 79
    Ashantee pepper, 589
    Asparagin, 93
      ” in Belladonna, 459
      ” in liquorice, 182
    Asparagus sarmentosus L., 15
    Aspartate of ammonium, 93
    Aspic, 479
    Aspidine, 735
    Aspidium Filix mas Swartz, 733
      ” Goldieanum Hooker, 733
      ” Oreopteris Sw., 735. 736
       ” spinulosum Sw., 735. 736
    ” marginale Sw., 733. 736
    Asplenium Filix fœmina Bernhard, 735. 736
    Assafœtida, 314
    Astragalus adscendens Boissier et Haussknecht, 174. 415
      ” brachycalyx Fischer, 174
      ” cylleneus Boiss. et Heldr., 175
      ” eriostylus B. et Hausskn., 177
      ” florulentus B. et Hkn., 415
      ” gummifer Labill., 174. 176
      ” kurdicus Boiss., 174
      ” leioclados Boiss., 174
      ” microcephalus Willd., 174
      ” pycnocladus B. et H., 174
      ” stromatodes Bunge, 174
      ” verus Olivier, 175
      ” yielding manna, 174
    Astaphis agria, 6
    Atís or Atees, 14
    Atraphaxis spinosa L., 415
    Atropa Belladonna L., 455
    Atropic acid, 457
    Atropine, 457
    Atrosin, 458
    Attar of rose, 262
      ” adulteration of, 237
    Aucklandia Costus Falconer, 382
    Atherosperma moschatum Labill., 539
    Atisine, 15
    Ativisha, 12
    Aubletia trifolia Rich., 114
    Aunée, 380
    AURANTIACEÆ, 114
    Azadirachta indica Jussieu, 154

    Babul or Babur, 234
    Bābunah, 386
    Baccæ Spinæ cervinæ, 157
    Baccæ, see Fructus
    Bactyrilobium Fistula Willd., 221
    Badiane, 20
    Bādiyāne-khatāi, 22
    Bael Fruit, 129
    Baisabole, 141
    Bakam, 216. 521
    Baldrianwurzel, 377
    Baliospermum montanum Müller Arg., 567
    Balisier, 633
    Balm of Gilead, 613
    Balsam, Canada, 612
      ” Capivi, 227
      ” Copaiba, 227
      ” Gurjun, 88
      ” of Peru, 205
      ” of Tolu, 202
    Balsamo blanco, 210
      ” catolico, 210
      ” negro, 207
    Balsamodendron africanum Arnott, 140
      ” Ehrenbergianum Berg, 140
      ” Myrrha Nees, 140
      ” Opobalsamum Kunth, 140
    Balsamum canadense, 612
      ” =Copaiba=, 227
      ” =Dipterocarpi=, 88
      ” Gurjunæ, 88
      ” indicum, 205
      ” nucistæ, 507
      ” =peruvianum=, 205
      ” Styracis, 271
      ” =tolutanum=, 202
    Barbaloïn, 687
    Barberry, indian, 34
    Barbotine, 387
    Bärentraubenblätter, 401
    Bärlappsamen, 731
    Barley, pearl, 722
    Baros camphor, 516
    Barosma betulina Bartl., 108
      ” Camphor, 109
      ” crenata Kunze, 108
      ” crenulata Hkr., 108
      ” Eckloniana Berg, 110
      ” serratifolia Willd., 108
    Barras or Galipot, 608
    Barwood, 202
    Bassia tree, 728
    Bassora gum, 178
    Bassorin, 178
    Bastaroni, 286
    Batatas Jalapa Choisy, 444
    Baume de Canada, 612
     ” Chio, 165
    Baume de Chypre, 165
     ” Copahu, 227
     ” Pérou, 205
     ” S. Salvador, 205
     ” Tolu, 202
    Baumöl, 417
    Bay-berry tree, 289
    Bay leaves (Pimenta acris), 284
    Bazghanj, 598
    Bdellium, 35
    Bearberry Leaves, 401
    Bebeeru or Bibiru Bark, 535
    Bebirine or Bibirine, 536
    Behenic acid, 68. 70
    Bela, 129
    Beli, 130
    Belladonna Leaves, 458
     ” Root, 455
    Belladonnine, 457
    Bendi-kai, 94
    Benic acid, 68. 70
    Benjoin, 403
    Benné Oil, 473
    Benzoëharz, 403
    Benzoic acid, 408
     ” in Balsam. Peruv., 208
     ” in Dragon’s Blood, 674
    Benzoin, 403
     ” Penang, 407
     ” Siam, 406
     ” Sumatra, 407
    Benzylic alcohol, 274
     ” cinnamate, 209
    BERBERIDEÆ, 34
    Berberine in Berberis, 36
     ” in Calumba, 25
     ” in Coptis, 5 ” in
    Podophyllum, 38
    Berberis aristata DC., 34
     ” asiatica Roxb., 35
     ” chinensis Desf., 36
     ” Lycium Royle, 34
     ” vulgaris L., 36
    Bergamot Camphor, 123
     ” essence of, 121
    Bergaptene, 123
    Bertramwurzel, 383
    Besenginster, 170
    Beta maritima L., 720
     ”-quinine, 358. 360
    Betel Nuts, 669
    Betelnüsse, 669
    Betula alba, tar of, 623
    Beurre de Cacao, 95
     ” Muscade, 507
    Bevilacqua, 297
    Beyo, 135
    Beyu, 135
    Bhang, 547. 548
    Bibiric acid, 536
    Bibirine, 28. 536
     ” sulphate, 536
    Bibiru Bark, 535
    Bigaradier, 124. 128
    Bikh, 12
    Bilack, 130
    Bilsenkraut, 463
    Bilva, 129
    Bisabol, 141. 145
    Bish, 12
    Bishop’s Weed, 302
    Bissa Bol, 145
    Bitter Apple, 295
     ” Wood, 131
     ”   ” Surinam, 133
    Bitter Orange Peel, 124
    Bittersüss, 450
    Bitter-sweet, 450
    BIXINEÆ, 75
    Blauholz, 212
    Blockwood, 213
    Blood-wood, 199
    Blumea balsamifera DC., 518
    Bockshornsamen, 172
    Boi (Bombay Sumbul), 313
    Boido, 135
    Boigue, 18
    Bois amer, 133
     ” de Campèche, 213
     ”     ” gaïac, 100
     ” gentil, 540
     ” d’Inde, 213
     ” de quassia, 133
     ”     ” santal, 599
     ”     ”     ” rouge, 199
    Bola, 142
    Bonduc Seeds, 211
    Bonplandia trifoliata Willdenow, 106
    Borassus flabelliformis L., 721
    Borneol, 517 ” in Valerian, 379
    Boswellia Bhan-Dajiana Birdwood, 134
     ” Carterii Birdwood, 134
     ” Frereana Birdwood, 135
    Boswellia glabra Roxb., 135
     ” neglecta Le Moore, 135
     ” papyrifera Richard, 135
     ” sacra Flückiger, 134
     ” serrata Roxb., 135
     ” thurifera Colebr., 135
    Botryopsis platyphylla Miers, 25
    Brasilin, 216
    Brassic acid, 67
    Brassica alba Hook. et Thoms., 68
     ” juncea Hook. et Thoms., 68
     ” nigra Koch, 64
    Brayera anthelminthica Kunth, 256
    Brazil wood, 216. 635
    Brechnüsse, 428
    Brechwurzel, 370
    Bréidine, 150
    Bréine, 150
    Brindones, 86
    Brindonia indica Dupetit Thouars, 86
    Bromaloïn, 687
    Broom Tops, 170
    Brucea antidysenterica Mill., 430
     ” ferruginea Héritier, 430
    Brucine, 430
    Bryoidin, 150
    Bubon Galbanum L. 320
    Buchu or Bucco Leaves, 108
    Buckthorn Berries, 157
    Buena hexandra Pohl, 358
     ” magnifolia Weddell, 364
    Bugbane, 15
    Buka Leaves, 108
    Bukublätter, 108
    =Bulbus Colchici=, 699
    =Bulbus Scillæ=, 690
    Burgundy pitch, 616
    BURSERACEÆ, 133
    Busserole, 401
    Butea frondosa Roxb., 197
     ” Kino, 197
     ” parviflora Roxb., 198
     ” superba Roxb., 198
    Butua, 26
    Butyrum Cacao, 95
    Buxine in Bibiru, 536
     ” in Pareira, 28
    Buxus sempervirens L., 536

    Caapeba, 27
    Cabbage Rose, 261
    Cabriuva preta, 211
    Cabueriba, 211
    Cacao Butter, 95
    Cachou, 240 ” jaune ou Gambir, 335
    Cacumina Scoparii, 170
    Cade, huile de, 623
    Cæsalpinia Bonduc Roxb., 211
     ” Bonducella Roxb., 211
     ” Sapan L., 521
    Cajuput Oil, 277
    Cajuputene or Cajuputol, 279
    Calabar Bean, 191
    Calabarine, 193
    Calamus aromaticus, 677
     ” Draco Willd., 672
    Caliaturholz, 199
    Calisaya Bark, 353
    Calotropis gigantea R. Brown, 424
     ” Hamiltonii Wight, 424
     ” procera R. Brown, 424
    Calumba Root, 23
    =Cambogia=, 83
    Camomille romaine, 384
    Campecheholz, 213
    Camphor, Barus, 516
     ” Blumea, 518
     ” Borneo, 516
     ” China, 515
     ” common, 510
     ” Dryobalanops, 516
     ” Formosa, 515
     ” Japan, 515
     ” laurel, 511
     ” Malayan, 516
     ” Ngai, 518
     ” oils, 516
    =Camphora=, 510
     ” officinarum Bauhin, 519
    Camphoric acid, 515
    Camphre, 510
    Camphretic acid, 139
    Canada Balsam, 612
    Canarium, 147
    Candy, 715
    Cane-Sugar, 714
     ” varieties of, 720
    Cane, sweet, 715
    Canefice, 221
    Canella alba Murray, 19. 20, 73. 635
    CANELLACEÆ, 73
    Canellin, 75
    Canna edulis Ker, 634
    Canna indica Ruiz et Pavon, 634
    Canna Starch, 633
    Cannabene, 549
    CANNABINEÆ, 546
    Cannabis indica Lamarck, 546
     ” sativa L., 546
    CANNACEÆ, 629
    Cannelle blanche, 73
     ” de Ceylan, 519
    Capivi, 229
    CAPRIFOLIACEÆ, 333
    Capsaïcin, 455
    Capsicin, 454
    Capsicum annuum L., 452
     ” fastigiatum Blume, 452
     ” grossum Willd., 452
     ” longum DC., 452
     ” minimum Roxb., 452
    =Capsulæ Papaveris=, 40
    Caqueta Bark, 353
    Caramania gum, 178
    Caraway, 304
    Cardamom, 643
     ” bastard, 649
     ” Bengal, 649 ” Ceylon, 647
     ” cluster, 648
     ” Java, 650
     ” Korarima, 650
     ” Malabar, 643
     ” Nepal, 649
     ” round, 648
     ” Siam, 649
     ” xanthioid, 649
    Cardamoms, Aleppi, 646
    Cardamomom majus, 650. 651
     ” siberiense, 21
    Carex arenaria L., 730
    =Caricæ=, 542
    Carmufellic acid, 285
    Carobbe di’ Giudea, 598
    Carolina Pink Root, 433
    Carony Bark, 106
    Carrageen, 747
    Carthagena Bark, 353
    Caram Ajowan Bentham et Hooker, 302
    Carum Carvi L., 304
     ” Ridolfia Benth., 328
    Carvene, 306
    Carvi, 304
    Carvol, 306. 329. 640
    =Caryophylli=, 280
     ” festucæ vel stipites, 286
    Caryophyllin, 285
    Caryophyllinic acid, 285
    Caryophyllum regium, 287
    Caryophyllus aromaticus Lamarck, 280
    Caryota urens L., 721
    Cascarilla Bark, 561
    Cascarilla del Angostura, 106
    Cascarillin, 563
    Casse ou canefice, 221
    Casia, 222
    Cassia acutifolia Delile, 216
     ” alba, 73
     ” angustifolia Vahl, 217
     ” Bark, 137. 527. 715
     ” brasiliana Lamarck, 224
     ” buds, 533
     ” Fistula L., 221
     ” grandis L. fil., 224
     ” lignea, 527. 530
     ” lignea jamaicensis, 75
     ” moschata Humb. B. et K., 224
     ” obovata Colladon, 118
     ” oil of, 2
     ” twigs, 533
     ” vera Bark, 530
     ” wood, 533
    Castor Oil, 569
      ”     ” Seeds, 567
    Catechin, 243. 337
     ” in Kino, 196. 199
    =Catechu=, 240
     ” Areca nut, 669
     ” black, 240
     ” Gambier, 335
     ” pale, 335
     ” pallidum, 335
     ” Pegu, 240
    Catechu-tannic acid, 243
    Cathartic acid, 243
    Cathartocarpus Fistula Persoon, 221
    Cathartogenic acid, 219
    Catharto-mannite, 220
    Caulis Dulcamaræ, 450 ” Tinosporæ, 31
    Cayenne Pepper, 452
    Cebadilla, 697
    Cedar oil, red, 628
    Cedrat, essence of, 128
    Cendal, 200
    Centifolienrosen, 261
    Cephaëlis Ipecacuanha Richard, 370
    Cerasus serotina DC., 253
    Cerealin, 724
    Cetraria islandica Achar., 737
    Cetraric acid, 739
    Cetrarin, 739
    Cevadic acid, 699
    Cevadilla, 697
    Cevadilline, 699
    Cevadine, 699
    Ceylon moss, 749
    Chærophyllum Anthriscus L., 302
    Chamomile, common, 384. 385
     ” flowers, 384
     ” german, 386
     ” roman, 384
    Chanvre indien, 546
    Charas, 550
    Chardinia xeranthemoides Desfont., 250
    Chasmanthera Columba Baill., 23
    Chaulmugra Seed, 75
    Chavica officinarum Miquel, 582
     ” Roxburghii Miq., 582
    Chelbenah, 321
    Chelidonium majus L., 3
    Chêne, écorce de, 593
    Cherry-laurel Leaves, 254
    Chesteb, 234
    Chiendent, 729 ” gros, 730
    Chillies, 452
    China bicolorata, 359
     ” nova, 364. 561
    China Root, 712
    Chinarinde, 338
    Chinasäure, 336
    Chinawurzel, 712
    Chinoïdin, 359
    Chinovic acid, 335
    Chinovin, 336
    Chiratin, 438
    Chiratogenin, 438
    Chiretta or Chirayta, 436
    Cholesterin, 420
     ” in barley, 725
     ” in ergot, 745
    Chondodendron tomentosum Ruiz et Pavon, 25
     ” tomentosum, stems of, 30
    =Chondrus crispus=, 747
    =Chondrus= mammillosus Grev., 749
    Chop-nut, 179
    Chren, 71
    Christmas Rose, 1
    Chrysammic acid, 689
    Chrysanthemum Parthenium Persoon, 386. 518
    Chrysophan, 499
     ” in Senna, 220
    Chrysophanic acid, 499
    Chrysoretin, 220
    Chrysorhamnine, 158
    Chuen-lien, 4
    Churrus, 550
    Chusalonga, 591
    Cicuta virosa L., 299. 332. 333
    Ciguë, feuilles de, 301 ” fruits de, 299
    Cimicifuga racemosa Elliott, 15
    Cimicifugin, 16
    Cinchona, acid principles of, 363
     ” alkaloids, 359
     ”    ” estimation of, 364
     ”    ” proportion in bark, 361
     ” Bark, 338
     ”   ” chemical composition of, 57
     ”   ” commerce in, 347
     ”   ” pale, 352
     ”   ” red, 353. 364
     ”   ” structure, 354
     ”   ” yellow, 353
     ” Calisaya Weddell, 340
     ” conspectus of, 355
     ” cultivation of, 348
     ” history of, 341
     ” lancifolia Mutis, 353
     ” magnifolia Pavon, 364
     ” officinalis Hooker, 340
     ” pitayensis Mutis, 353
     ” -red, 353
     ” succirubra Pavon, 341
     ” works relating to, 367
    Cinchonicine, 359
    Cinchonidine, 361
    Cinchonine, 361
    Cincho-tannic acid, 363
    Cinchovatine, 358
    Cinene or Cynene, 389
    Cinnameïn, 209
    Cinnamic acid, 526
    Cinnamic acid in Bals. Peruv., 208
     ”         ” Tolut., 204
     ”         ” in benzoin, 408
     ”         ” aldehyde, 526
    Cinnamodendron corticosum Miers, 19
    Cinnamomum, Burmanni Blume, 528
     ” Camphora Nees, 510
     ” Cassia, 528
     ” iners Reinwardt, 528. 533
     ” obtusifolium Nees, 528
     ” pauciflorum Nees, 528
     ” Tamala Nees, 528
     ” zeylanicum Breyne, 519
    Cinnamon, 519
     ” chinese, 530
     ” chips, 524
     ” leaf, oil of, 529
     ” oil of, 526
     ” root, oil of, 529
    Cinnamon Bark (Bahamas), 73
    Cinnamylic cinnamate, 274
    Cipo de cobras, 27
    Cirifole, 130
    Cissampelos Pareira, 29
    Cistus creticus L., 141
    Cistus ladaniferus L., 416
    Citric acid, 116
    Citridic acid, 11
    Citron, 114
    Citronella Oil, 726
    Citronellol, 727
    Citrullus Colocynthis Schrader, 295
    Citrus Aurantium L., 124
     ” Bergamia Risso et Poiteau, 121
     ” Bigaradia Duhamel, 124
     ” decumana L., 117
     ” Limonum Risso, 114. 118
     ” medica L., 114. 128
     ” vulgaris Risso, 124. 126
    Claviceps purpurea Tulasne, 740
    Clematis Vitalba L., 29
    Clous de girofles, 280
    Clove-bark, 285
    Clove Leaves, 286
     ” Stalks, 286
    Cloves, 280
     ” Mother, 286
     ” oil of, 284
     ” Royal, 287
    Cniquier, 211
    Cocca gnidia, 540
    Cocculus Chondodendron DC., 25
    Cocculus cordifolius DC., 33
     ” indicus, 31
     ” palmatus DC., 23
    Cochlearia Armoracia L., 71
    Cocos nucifera L., 721
    Codamine, 59
    Codagam, 297
    Codeine, 42. 58. 59. 62
    Cohosh, 15
    Coing, semences de, 269
    Col, 329
    Colchiceïn, 702
    Colchicin, 702
    Colchicum autumnale L., 699
     ” other species, 701
     ” Seed, 702
    Colchique, bulbe de, 699
     ” semence de, 702
    Colocynth, 295
    Colocyntheïn, 296
    Colocynthin, 296
    Colocynthitin, 296
    Colombo Root, 23
    Colophonia mauritiana DC., 152
    Colophony, 607
    Coloquinte, 295
    Coloquintida, 295
    Columba-Bitter, 25
    Columbian Bark, 353
    Columbic acid, 25
    Columbin, 25
    Colutea arborescens L., 221
    Comenic acid, 58
    COMPOSITÆ, 380
    Concombre purgatif ou sauvage, 292
    Conglutin, 247
    Conhydrine, 300
    Conia or Conine, 300
    CONIFERÆ, 604
    Coniferin, 659
    Conine, 300
    Conium maculatum L., 299. 301
    Conquinine, 360
    CONVOLVULACEÆ, 438
    Convolvulic acid, 445
    Convolvulin, 445
    Convolvulinol, 445
    Convolvulinolic acid, 446
    Convolvulus Nil L., 448
     ” Purga Wenderoth, 443
     ” Scammonia L., 438
    Conylene, 300
    Copahu, 227
    Copaiba or Copaiva, 227
    Copaifera bijuga Hayne, 228
     ” cordifolia Hayne, 228
     ” coriacea Martius, 228
     ” glabra Vogel, 228
     ” guianensis Desfont., 227
     ” Jacquini Desfont., 227
     ” Jussieui Hayne, 228
     ” Langsdorffii Desfont., 228
     ” laxa Hayne, 228
     ” multijuga Hayne, 228
     ” nitida Hayne, 228
     ” officinalis L., 227
     ” Sellowii Hayne, 228
    Copaivic acid, 231
    Copalchi Bark, 564
    Coptis Root, 3
     ” Teeta Wall., 3
     ” trifolia Salisb., 5
    Coque du Levant, 31
    Coquelicot, 39
    Cordiceps, 743
    Cordyliceps, 743
    Corail des jardins, 452
    Coriander, 329
    Coriandrum sativum L., 329
    Coriaria myrtifolia L., 221
    =Cormus Colchici=, 699
    =Cortex Alstoniæ=, 421
     ” =Angosturæ=, 106
     ” =Aurantii=, 124
     ” Azadirachtæ, 154
     ” =Berberidis=, 34
     ” =Bibiru=, 535
     ” =Canellæ albæ=, 73
     ” =Cascarillæ=, 561
     ” =Cassiæ ligneæ=, 527
     ” Chinæ, 338
     ” =Cinchonæ=, 338
     ” =Cinnamomi=, 519
     ” Cuspariæ, 106
     ” Eleutheriæ, 561
     ” =Granati fructus=, 289
     ” =Granati radicis=, 290
     ” =Laricis=, 611
     ” Limonis, 116
     ” Magellanicus, 17
     ” =Margosæ=, 154
     ” =Mezerei=, 540
     ” =Mudar=, 424
     ” Nectandræ, 535
     ” Peruvianus, 338
     ” =Pruni serotinæ=, 253
     ” =Quercus=, 593
     ” Sassafras, 538
     ” =Soymidæ=, 156
     ” Swieteniæ, 156
     ” Thymiamatis, 273. 276
     ” =Ulmi=, 556
     ”    ”   =fulvæ=, 557
     ” =Winteranus=, 17
    Costus, 35. 382. 503. 520. 523
     ” corticosus, 73
     ” dulcis, 73
     ” root, 383
    Cotarnine, 58
    Cotoneaster nummularia Fischer et Meyer, 415
    Couch Grass, 729
    Cowberry, 402
    Cowhage, 189
    Cow-itch, 190
    Cran de Bretagne, 71
    Cratæva Marmelos L., 129
    Creyat or Kariyat, 472
    Crinum asiaticum Herbert, 693
     ” toxicarium Roxb., 693
    Crocetin, 667
    Crocin, 667
    =Crocus=, 663
     ” sativus L., 663
    Croton Cascarilla Bennett, 562
     ” Draco Schlechtendal, 676
     ” Eluteria Bennett, 561
     ” lucidus L., 564
     ” niveus Jacquin, 564
     ” oblongifolius Roxb., 567
     ” Oil, 566
     ” Pavanæ Hamilton, 567
     ” philippensis Lamarck, 572
     ” polyandrus Roxb., 567
     ” Pseudo-China Schl., 564
     ” Seeds, 565
     ” Tiglium L., 565
    Crotonic acid, 566
    Crotonol, 566
    Crown Bark, 352
    CRUCIFERÆ, 64
    Cryptopine, 59. 63
    Cubeba canina Miq., 588
     ” Clusii Miq., 589
     ” crassipes Miq., 588
    Cubeba Lowong, Miq., 588
     ” officinalis Miq., 587
     ” Wallichii Miq., 588
    =Cubebæ=, 584
    Cubebic acid, 587
    Cubebin, 587
    Cubebs, 582. 635
     ” african, 589
     ” camphor, 587
    Cucumber, squirting or wild, 292
    Cucumis Colocynthis L., 295
     ” Hardwickii Royle, 297
     ” Prophetarum L., 294
     ” Pseudo-colocynthis Royle, 297
     ” trigonus Roxb., 297
    CUCURBITACEÆ, 292
    Cumic acid, 332
    Cumin, 305. 331
     ” armenian, 305
     ” roman, 331
    Cuminaldehyde, 332
    Cuminol, 332
    Cuminum Cyminum L., 331
    Cummin seeds, 331. 635
    CUPULIFERÆ, 593
    Curcuma angustifolia Roxb., 634
     ” leucorrhiza Roxb., 634
     ” longa L., 638
     ” starch, 634
    Curcumin, 640
    Cusconine, 359
    Cuscus Grass, 728
    Cusparia Bark, 106
     ” trifoliata Engler, 106
    Cusparin, 107
    Cusso or Koso, 256
    Cutch, 240
    Cydonia vulgaris Persoon, 269
    Cymene or Cymol from ajowan, 304
     ” from alantcamphor, 381
     ”   ”  camphor, 515
     ”   ” cumin, 333
     ”   ” santonica, 389
     ”   ” thyme, 488
    =Cynanchum Argel Hayne=, 220
     ” Vincetoxicum R. Brown, 97
    Cynanchol, 398
    Cynene or Cinene, 389
    Cynips Gallæ tinctoriæ Oliv., 506
    Cynodon Dactylon Pers., 729. 730
    Cynorrhodon, 268
    Cynosbata, 268
    Cypripedium pubescens Willd., 79. 593
    Cytisine, 172
    Cytisus Laburnum L., 172
     ” scoparius Link, 170

    Dæmonorhops Draco Martius, 672
    Dalleiochine, 360
    Dandelion Root, 392
    Daphne Gnidium L., 542
     ” Laureola L., 541
     ” Mezereum L., 540
    Daphnetin, 541
    Daphnin, 541
    Date, Indian, 225
    Datura alba Nees, 462
     ” fastuosa L., 459. 462
     ” Stramonium L., 459
     ” Tatula L., 460
    Daturine, 461
    Delphinine or Delphine, 7
    Delphinium Staphisagria L., 5
    Delphinoïdine, 7
    Delphisine, 7
    Dhak, 197
    Dhak Tree, 107
    Diagrydion, 439
    Dicypellium caryophyllatum Nees, 285
    Digitaléin, 472
    Digitalin, 470
    Digitalis purpurea L., 469
    Digitoxin, 471
    Dill, 327
    Diospyros Embryopteris Persoon, 403
     ” virginiana L., 403
    Diplolepis Gallæ tinctoriæ Latreille, 596
    Diplotaxis erucoides DC., 65
    DIPTEROCARPEÆ, 88
    Dipterocarpus alatus Roxb., 88
     ” gracilis Blume, 88
     ” hispidus Thwaites, 88
     ” incanus Roxb., 88
     ” indicus Beddome, 88
     ” lævis Ham., 88
     ” littoralis Bl., 88
     ” retusus Bl., 88
     ” Spanoghei Bl., 88
     ” trinervis Bl., 88
     ” tuberculatus Roxb., 243
     ” turbinatus Gärtn., 88
     ” zeylanicus Thw., 88
    Diss, 747
    Dita bark, 421
    Ditaïne, 422
    Dithin, 140
    Dog-rose, 268
    Dog’s Grass, 729
    Dolichos pruriens L., 189
    Dorema Ammoniacum Don, 313. 324
     ” Aucheri Boissier, 325
     ” robustum Loftus, 325
    Douce-amère, 450
    Dracæna Draco L., 672
     ” Ombet Kotschy, 675
     ” schizantha Baker, 675
    Drachenblut, 672
    Draconyl, 674
    Dracyl, 675
    Dragon’s Blood, 137
     ”         ”   Canary Islands, 675
     ”         ”   drop, 675
     ”         ”   lump, 673
     ”         ”   reed, 673
     ”         ”   Socotra, 675
    Drimia ciliaris Jacq., 693
    Drimys Winteri Forster, 17
    Droga amara, 472
    Dryandra cordata Thunb., 91
    Dryobalanops aromatica Gärtner, 229. 516
    Dulcamara, 450
    Dulcamarine, 451

    Earth-nut Oil, 186
    EBENACEÆ, 403
    Ecballine, 294
    Ecballium Elaterium Richard, 292
    Ecboline, 745
    Echicaoutchin, 422
    Echicerin, 398. 422
    Echinus philippinensis Baillon, 572
    Echites scholaris L., 421
    Echitin, 422
    Ecorce de Winter, 17
    Eibischwurzel, 92
    Eichenrinde, 593
    Ein or Engben, 243
    Eisenhut, 8
    Elæis guineensis Jacquin, 194
    Elaeococca Vernicia Sprgl., 91
    Elaïdic acid, 187. 475
    Elaphrium, 147
    Elateric acid, 294
    Elateride, 294
    Elaterin, 294
    Elaterium Fruit, 292
    Elder Flowers, 333
    Elecampane, 380
    Eleme, 544
    =Elemi=, 147
     ” african, 152
     ” brazilian, 152
     ” Mauritius, 152
     ” mexican, 152
     ” oriental, 135. 152
     ” Vera Cruz, 152
    Elemic acid, 151
    Elettaria Cardamomum Maton, 643
     ” major Smith, 644
    Eleusine coracana Gärtner, 241
    Eleuthera Bark, 561
    Ellagic acid, 291
    Ellébore blanc, 693
     ” noir, 1
    Elm Bark, 556
     ” slippery, 557
    Embryopteris glutinifera Roxb., 403
    Embelia Ribes Burmann, 581
    Emetine, 374
    Emodin, 499
    Empleurum serrulatum Ait., 110
    Emulsin, 247
    Encens, 133
    Enckea reticulata Miq., 114
    Enhæmon, 147. 148
    Entershah, 267
    Enzianwurzel, 434
    Eosin, 323
    Epacris, 402
    Equisetic acid, 11
    Erdnussöl, 186
    Ergot of diss, 747
     ” oat, 747
     ” rye, 740
     ” wheat, 746
    Ergota, 740
    Ergotine, 745
    ERICACEÆ, 401
    Ericinol, 402
    Ericolin, 402
    Erucic acid, 67. 160
    Erucin, 70
    Erythroretin, 499
    Esenbeckia febrifuga Martius, 107
    Eseré Nut, 191
    Eserine, 193
    Essigrosenblätter, 259
    Eucalyptus citriodora Hooker, 199
     ” corymbosa Smith, 199
     ” gigantea Hooker, 199
     ” globulus Labill., 280. 333
     ” Kino, 199 ” Manna, 417
     ” Oil, 280
     ” obliqua L’Hér., 199
     ” oleosa F. Müller, 289
     ” resinifera Smith, 195
     ” rostrata Schlechtend., 199
     ” viminalis Labill., 417
    Eugenia caryophyllata Thunberg, 280
     ” Pimenta DC., 287
    Eugenic acid, 284
     ”        ”   in Canella, 75
    Eugenin, 285
    Eugenol, 75. 284. 319. 527. 659
    Eugetic acid, 319
    Eulophia yielding Salep, 655
    Eupatorium glutinosum Lamck., 591
    Euphorbia resinifera Berg, 558
    Euphorbic acid, 560
    EUPHORBIACEÆ, 558
    =Euphorbium=, 558
    Euphorbon, 398, 560
    Euryangium Sumbul Kauffm., 312
    Evodia febrifuga St. Hilaire, 107
    Exacum, 438
    Exogonium Purga Bentham, 443
    Extractum Glycyrrhizæ, 183
     ” Uncariæ, 335

    Faba Calabarica, 191
     ” Physostigmatis, 191
     ” Sancti Ignatii, 431
    Fagus silvatica, tar of, 623
    Farnwurzel, 733
    Feigen, 542
    Fenchel, 308
    Fennel, 308
     ” bitter, 309
     ” german, 309
     ” indian, 309
     ” oils of, 310
     ” roman, 309
     ” saxon, 309
     ” sweet, 308
     ” wild, 309
    Fenouil, 308
    Fenugreek, 172
    Fern Root, 733
    Feronia Elephantum Correa, 131. 239
     ” gum, 239
    Ferreirea spectabilis Allemão, 81
    Ferula alliacea Boissier, 320
     ” Asafœtida Boissier et Buhse, 320
     ” Asafœtida L., 314
     ” erubescens Boiss., 321
     ” galbaniflua Boiss. et Buhse, 321
     ” Narthex Boiss., 314
     ” rubricaulis Boiss., 321
     ” Scorodosma Benth. et Hkr., 314
     ” Sumbul Hooker, 312
     ” teterrima Karelin et Kiril., 320
     ” tingitana L., 327
    Ferulago galbanifera Koch, 320
    Ferulaic acid, 319
    Festucæ Caryophylli, 286
    Fève de Calabar, 191
     ” Saint Ignace, 431
    Feverfew, 386
    Fichtenharz, 616
    Fichtentheer, 619
    Ficus Carica L., 542
    Figs, 542
    FILICES, 733
    Filicic acid, 735
    Filixolic acid, 735
    Filixolin, 735
    Filix-red, 735
    Filosmylic acid, 735
    Fingerhutblätter, 469
    Fir, Balsam or balm of Gilead, 612
     ” Norway Spruce, 616
     ” Silver, 615
    Flachssamen, 97
    Flag, blue, 660
     ” root, sweet, 676
     ” yellow, 678
    Flax Seed, 97
    Fliederblumen, 333
    =Flores Anthemidis=, 384
     ” =Arnicæ=, 390
     ” Cassæi, 533
     ” Chamomillæ romanæ, 384
     ” Cinæ, 387
     ” =Koso=, 256
     ” =Lavandulæ=, 476
     ” Rhœados, 39
     ” Rosæ incarnatæ, 261
     ”         ”     pallidæ, 261
     ”         ”     rubræ, 259
     ”         ”     Stœchados, 479
    FLORIDEÆ, 747. 749
    Fœniculum capillaceum Gilibert, 308
     ” dulce DC., 308
     ” Panmorium DC., 309
     ” sinense, 22
     ” vulgare Gärtner, 308
    Fœnum Camelorum, 728
    Fœnum græcum, 172
    Fofal, 669
    =Folia Aconiti=, 11
     ” =Belladonnæ=, 458
     ” =Buchu=, 108
     ” =Conii=, 301
     ” =Daturæ albæ=, 462
     ” =Digitalis=, 469
     ” =Hyoscyami=, 463
     ” Indi, 533 ” Jaborandi, 113
     ” =Lauro-cerasi=, 254
     ” Malabathri, 533
     ” Matico, 589
     ” =Pilocarpi=, 113
     ” =Sennæ=, 216
     ” =Tabaci=, 466
     ” =Tylophoræ=, 427
     ” =Uvæ Ursi=, 401
    Fool’s Parsley, 302
    Fougère mâle, 733
    Foxglove Leaves, 469
    Frankincense, 133
     ” common, 608
    Fraxetin, 413
    Fraxin, 413
    Fraxinus Bungeana DC., 409
     ” excelsior L., 409
     ” Ornus L., 409
    =Fructus Ajowan=, 302
     ” =Anethi=, 327
     ” =Anisi=, 310
     ”      ”    =stellati=, 20
     ” =Belæ=, 129
     ” =Capsici=, 452
     ” =Cardamomi=, 643
     ” Caricæ, 542
     ” =Carui=, 304
     ” =Cassiæ fistulæ=, 221
     ” Cocculi, 31
     ” =Colocynthidis=, 295
     ” =Conii=, 299
     ” =Coriandri=, 329
     ” Cubebæ, 664
     ” =Cumini=, 331
     ” =Diospyri=, 403
     ” =Ecballii=, 292
     ” Elaterii, 292
     ” =Fœniculi=, 308
     ” =Hibisci=, 94
     ” =Juniperi=, 624
     ” =Limonis=, 114
     ” =Mori=, 544
     ” Papaveris, 40
     ” =Pimentæ=, 287
     ” =Piperis longi=, 582
     ”       ”    =nigri=, 576
     ” =Pruni=, 251
     ” =Rhamni=, 157
     ” =Rosæ caninæ=, 268
    Fu, 377
    =Fucus amylaceus=, 749
     ” crispus L., 747
     ” hibernicus, 747
    Fucosol, 748
    FUNGI, 740
    Fuh-ling, 714
    Fusanus spicatus Br., 599. 601
    Fuscosclerotinic acid, 745
    Fusti, 286

    Gæidinic acid, 187
    Gaïac, bois de, 100
     ” résine, 103
    Galanga major, 643
     ” minor, 671
    Galangal, 641
     ” greater, 643
    =Galbanum=, 320
    Galbuli Juniperi, 624
    Galgant, 651
    Galipea Cusparia St. Hil., 106
     ” officinalis Hancock, 106
    Galipot or Barras, 607
    =Gallæ chinenses=, 167
     ” =halepenses=, 595
     ” =japoncæ=, 167
    Galläpfel, 595
    Galle d’Alep, 1. 595
    Gallic acid from galls, 169. 597
    Gallo-tanic acid, 169. 597
    Galls, Aleppo, 595
     ” blue, 596 ” Bokhara, 598
     ” chinese, 167
    Galls, green, 596
     ” japanese, 167
     ” oak, 595
     ” Pistacia, 165. 598
     ”Tamarisk, 598
     ” turkey, 595
     ” white, 596
    =Gambier=, 335
    Gamboge, 83
    Ganja, 548
    Garcinia indica Choisy, 86
     ” Morella Desr., 83
     ” pictoria Roxb., 83
     ” purpurea Roxb., 86
     ” travancoria Bedd., 86
    Garou, 542
    Gayac, bois de, 100
     ” résine de, 103
    Gaz Alefi, 415
     ”-anjabin, 414
     ” Khonsari, 415
    Gaultheria procumbens L., 402
    Gelbwurzel, 638
    Gelose, 750
    Gelsemium nitidum Mich., 541
     ” sempervirens Ait., 541
    Genêt à balais, 170
    Genièvre, 624
    Genista, 170
    Gentian-bitter, 435
     ” Root, 434
    Gentiana Catesbæi Walter, 436
     ” Chirayita Roxb., 436
     ” lutea L., 434
     ” pannonica Scopoli, 436
     ” punctata L., 436
     ” purpurea L., 436
     ” Saponaria L., 436
    GENTIANEÆ, 434
    Gentianic acid, 435
    Gentianin, 435
    Gentiogenin, 435
    Gentiopicrin, 435
    Geranium Oil, 267. 726. 728
    Gergelim, 474
    Germer, 693
    Gerste, 722
    Geum urbanum L., 390. 391
    Gewürznelken, 280
    Ghittaiemou, 83
    Giftlattich, 395
    Gigartina acicularis Lamour., 749
    Gigartina mammillosa J. Agardh, 749
    Gigambo, 94
    Gingeli Oil, 473
    Gingembre, 636
    Ginger, 635
     ” grass oil, 726
    Gingili Oil, 473
    Ginseng, American, 79
    Girofles, 280
     ” griffes de, 286
    Gizeis, Gizi, 222
    =Glandulæ Humuli=, 554
     ” Rottleræ, 562
    Glycyrretin, 181. 182
    Glycyrrhiza echinata L., 179
     ” glabra L., 179. 183
     ” glandulifera Waldst. et Kit., 179
    Glycyrrhizin, 181
    Gnoscopine, 59
    Gombo, 94
    Gomme arabique, 233
     ” Gutte, 83
    Goolwail, 33
    Goudron végétal, 619
    Gracillaria confervoides Grev., 749
     ” lichenoides Grev., 749
    Grahe’s test, 336
    Grains, Guinea, 651
     ” of Paradise, 651
    Graines des Moluques, 565
     ” de Tilly, 565
    GRAMINEÆ, 714
    =Grana Paradisi=, 651
    GRANATEÆ, 289
    Granatill, 565
    Granatin, 291
    Granatschalen, 289
    Granatwurzelrinde, 290
    Granulose, 631
    Grass, Couch, 729
     ” Dog’s, 729
     ” Lemon, 725
     ” Oil, indian, 725
     ” Oil of Nimar, 726
     ” Quitch, 729
    Graswurzel, 729
    Greenheart Bark, 535
    Grenades, écorce de, 289
    Grenadier, écorce de racine de, 290
    Grieswurzel, 25
    Ground-nut Oil, 186
    Guaiac Beta-resin, 105
    Guaiac-yellow, 105
    Guiacene, 105
    Guaicic acid, 105
    Guaiacol, 105
    Guaiaconic acid, 104
    Guaiacum officinale L., 100. 103
     ” Resin, 103
     ” sanctum L., 100
     ” Wood, 100
    Guaiakharz, 103
    Guaiakholz, 100
    Guaiaretic acid, 104
    Guaiol, 105
    Guaza, 548
    Guilandina Bonducella L., 211
    Guimauve, 92
    Guinea Grains, 651
     ” Pepper, 452
    Gula, 715
    =Gulancha=, 33
    Gule-pistah, 598
    Gum Arabic, 233
     ” Australian, 237
     ” Barbary, 237 ” Bassora, 239
     ” Benjamin, 403
     ” Cape, 237
     ” Caramania, 178
     ” East India, 237
     ” Feronia, 239
     ” flooded, 199
     ” Gedda, 236
     ” Hog, 178
     ” Jiddah, 236
     ” Mesquite, 239
     ” Mogador, 237
     ” Morocco, 237
     ” Mosul, 178
     ” red, 199
     ” Senegal, 236
     ” Suakin, 235. 237
     ” Talca or Talha, 234
     ” Thus, 608 ” Tragacanth, 174
     ” Wattle, 237
     ” white, 199
    =Gummi Acaciæ=, 233
     ” arabicum, 233
    Gummigutt, 83
    Gummis acanthinum, 234
     ” Sennaar, 236
    Guragi, 650
    Gurjun Balsam, 88
    Gurjunic acid, 90
    Gutti, 83
    GUTTIFERÆ, 83
    GYMNOSPERMS, 604
    Gynocardia odorata R. Brown, 75

    Habaghadi, 140. 145
    Hæmateïn, 214
    Hæmatoxylin, 214
    Hæmatoxylon campechianum L., 213
    Hagebutten, 268
    Hagenia abyssinica Willd., 256
    Hagenic acid, 258
    HAMAMELIDEÆ, 271
    Hanfkraut, 546
    Hardwickia pinnata Roxb., 232
    Hartsthorn, 157
    Hashab, 233. 235
    Hashish, 548
    Hawkbit, 394
    Hedeoma pulegioides Pers., 486
    Helenin, 381
    Hellebore, black, 1
     ” white, 693
     ” american, 695
    Heil, 650
    Helleboreïn, 3
    Helleboresin, 2
    Helleboretin, 3
    Helleborin, 2
    Helleborus fœtidus L., 2
     ” niger L., 1
     ” orientalis Lam., 1
     ” purpurascens Waldst. et Kit., 2
     ” viridis L., 2. 3. 695
    Helonias frigida Lindley, 695
    Hématine, 214
    Hemidesmus indicus R. Brown, 423
    Hemlock fruits, 299
     ” leaves, 301
    Hemlock Spruce, 612
    Hemp, Indian, 546
    Henbane leaves, 463
    Herabol, 140. 146
    Herapathite, 360
    Herba Aconiti, 11
     ” =Andrographidis=, 472
     ” Anthos, 488
     ” =Cannabis=, 546
     ” Chiratæ=, 436
     ” =Hydrocotyles=, 297
     ” =Lactucæ=, 395
     ” =Lobeliæ=, 399
     ” =Matico=, 589
     ” =Menthæ piperitæ=, 481
     ” =Menthæ viridis=, 479
     ” Nicotianæ, 466
     ” pedicularia, 6
     ” =Pulegii=, 486
     ” =Rosmarini=, 488
     ” =Sabinæ=, 626
     ” Schœnanthi s. Squinanthi, 728
     ” =Scoparii=, 170
     ” =Stramonii=, 459
     ” =Thymi vulgaris=, 487
    Hermodactylus, 701
    Herva de Nossa Senhora, 27
    Hesperetic acid, 117
    Hesperetin, 116
    Hesperidin, 116. 126
    Hexenmehl, 731
    Hibiscus esculentus L., 94
    Hill colocynth, 297
    Hiltit, 316
    Hing, 318
    Hingra, 319
    Hips, 268
    Hodthai, 146
    Hog gum, 178
    Holcus saccharatus L., 721
    Holunderblüthe, 333
    Holztheer, 619
    Hopfen, 551
    Hopfenbittersäure, 555
    Hopfendrüsen, 554
    Hopfenstaub, 554
    Hops, 551
    Hordeinic acid, 725
    =Hordeum decorticatum=, 722
     ” distichum L., 722
     ” perlatum, 722
    Hornbast, 74. 157
    Horse-radish, 71
    Houblon, 551
    Huile d’Arachides, 186
     ” de Cade, 623
     ” d’enfer, 419 ” fermentée, 419
     ” d’Olives, 417
     ” tournante, 419
    Hulba, 173
    Humulus Lupulus L., 551
    Humulotannic acid, 553
    Hwang-lien, 4
    Hydnocarpus inebrians Vahl, 77
     ” odorata Lindley, 75
     ” venenata Gärtner, 76
     ” Wightiana Blume, 76
    Hydrocotarnine, 59
    Hydrocotyle asiatica L., 297
     ” rotundifolia Roxb., 298
     ” vulgaris L., 298
    Hydrocyanic acid, 249. 250. 255
    Hydrokinone, 401
    Hyoscine, 465
    Hyoscinic acid, 465
    Hyoscyamine, 464
    Hyoscyamus albus L., 463. 465
     ” insanus Stocks, 466
     ” niger L., 204. 463
    Hypogæic acid, 187
    Hypopicrotoxic acid, 33

    Ibischa, 92
    Iceland Moss, 737
    Icica Abilo Blanco, 147
     ” altissima Aublet, 152
     ” Caranna Humb. B. et K., 152
     ” guianensis Aubl., 152
     ” heptaphylla Aubl., 152
     ” heterophylla DC., 152
     ” Icicariba DC., 152
     ” various species, 147
    Idris yaghi, 267. 728
    Igasuric acid, 433
    Igasurine, 430
    Ignatiana philippinica Loureiro, 431
    Ignatius Beans, 431
    Ilāchi, 644
    Illicium anisatum Loureiro, 20
     ” religiosum Siebold, 20
    Imperata Königii P. de B., 336
    Imperatoria Ostruthium L., 10
    Indian Bael, 129
     ” Hemp, 546
     ” Pink Root, 433
     ” Poke, 695
    Indravarunī, 295
    Ingwer, 635
    Inimboja, 211
    Inosite, 394. 472
    Inula Helenium L., 380
    Inulin, 382
    Inulin, from Arnica, 391
     ”       ”   Taraxacum, 394
    Inuloïd, 382
    Ionidium, 375. 382
    Ipéca sauvage, 427
    Ipecacuanha, 370
     ” Carthagena, 373
     ” Indian, 427
     ” New Granada, 373
     ” striated, 376
     ” undulated, 376
    Ipecacuanhic acid, 374
    Ipomœa dissecta Willd., 251
     ” Jalapa Pursh, 441
     ” orizabensis Ledanois, 446
     ” Purga Hayne, 443
     ” simulans Hanbury, 447
    Ipomœic acid, 446
    IRIDACEÆ, 660
    Iris florentina L., 660
     ” germanica L., 660
     ” nepalensis Wall., 663
     ” pallida Lamarck, 660
     ” Pseudacorus L., 678
    Irländisches Moos, 747
    Ishpingo, 533
    Isländisches Moos, 737
    Isobutyric acid, 391
    Isolusin, 79
    Ispaghul Seeds, 490
    Isuvitinic acid, 85

    Jaborandi, 113. 114
    Jadvar, 14
    Jaffna moss, 749
    Jaggery, 720
    Jalap, 443
     ” fusiform, light or male, 446
     ” resin of, 445
     ” stalks or tops, 446
     ” Tampico, 447
     ” Vera Cruz, 446
     ” woody, 446
    Jalapin, 445
     ” of Mayer, 447
     ” in scammony, 441
    Jamaica pepper, 287
     ” Winter’s Bark, 75
    Jateorhiza palmata Miers, 23
    Jernang, 673
    Jervic acid, 695
    Jervine, 694. 696
    Jeukbol, 672
    Jinjili Oil, 473
    Ju-siang, 137
    Juckborsten, 189
    Juncus odoratus, 728
    Juniper Berries, 624
     ” Tar, 523
    Juniperus communis L., 624
     ” nana Willd., 625
     ” Oxycedrus L., 623
     ” phœnicea L., 628
     ” Sabina L., 626
     ” virginiana L., 628
    Jusquiame, 463
    Justicia paniculata Burmann, 472

    Kaddigbeeren, 624
    Kakul, 234
    Kaladana, 448
    Kalmia latifolia L., 402
    Kalmus, 676
    Kalumb, 24
    Kalumbawurzel, 23
    =Kamala= or Kamela, 572
    Kamalin, 575
    Kamanan, 403
    Kami, 234
    Kamillen, 386
    Kaminan, 403
    Kämpferid, 643
    Kanbil, 572
    Kand, 715
    Kandahari-Hing, 317
    Kaneel, 519
    Kapi-Kachchu, 190
    Kapila or Kapila-podi, 572
    Karawya, 305
    Kariyat or Creyat, 472
    Karroodoorn, 237
    Kasia, 222
    Kat or Kut, 241. 242
    Kayu-puti Oil, 277
    Keersal, 244
    Kentrosporium, 743
    Kesso, 380
    Khulakhudi, 297
    Kikar, 234
    Kinbil, 572. 573
    Kinic acid, 363. 402. 595
    Kinnah, 321
    =Kino=, 194
     ” African, 198
     ” Australian, 198
     ” Bengal, 197
     ” Botany Bay, 198
     ” Butea, 197
     ” East Indian, 194
     ” Eucalyptus, 199
     ” Gambia, 198
     ” Palas or Pulas, 197
    Kinoïn, 197. 199
    Kinone, 363. 402
    Kino-red, 196
    Kino-tannic Acid, 196
    Kirāta-tikta, 436
    Kirschlorbeerblätter, 254
    Kiwanch, 190
    Klatschrosen, 39
    Knorpeltang, 747
    Kokkelskörner, 31
    Kokum Butter, 86
    Korarima, 650
    Kordofan-Gummi, 233
    Koriander, 329
    Kosala, 259
    Kosin, 258
    Koso, Kosso, Kousso, 256
    Kostus, 383
    Krameria argentea Martius, 81
     ” cistoidea Hooker, 80
     ” grandifolia Berg, 82
     ” Ixina Triana, 82
     ” secundiflora DC., 82
     ” tomentosa St. Hilaire, 82
     ” triandra Ruiz et Par., 79
    Krenai, 71
    Kreuzdornbeeren, 157
    Kreuzkümmel, 331
    Kümmel, 304
     ” langer oder römischer, 331
    Kunkuma, 664
    Kurkuma, 638
    Kustumburu, 329
    Kut or Kat, 241. 242
    Kutakan, 297
    Kyphi, 141. 172

    LABIATÆ, 476
    Laburnine, 172
    Lactuca altissima Bieberst., 396
     ” capitata DC., 396
     ” elongata Mühlenbk., 396
     ” sativa L., 396
    Lactuca Scariola, 395
     ” virosa, 395. 396
    =Lactucarium=, 396
    Lactucerin, 398
    Lactucic acid, 398
    Lactucin, 398
    Lactucone, 398
    Lactucopicrin, 398
    Ladanum, 141
    Lævulinic acid, 748
    Laitue vireuse, 395
    Lakriz, 179. 183
    Lakrizwurzel, 179
    Lalang grass, 336
    Lanthopine, 59
    Larch Bark, 611
     ” Turpentine, 609
    Larix europæa DC., 609. 611
     ” sibirica Ledebour, 619
    Larixin, 611
    Larixinic acid, 611
    Laser, 315
    Laudanine, 59
    Laudanosine, 59
    LAURACEÆ, 510
    Laurel oil, 540
    Laurel, common, 254
    Laurier-cerise, 254
    Laurocerasin, 255
    Laurus Camphora L., 510
     ” Cubeba Loureiro, 588
     ” Sassafras L., 537
    Läusesamen, 5. 697
    Lavandula lanata Boissier, 479
    Lavandula Spica DC., 478
     ” Stœchas L., 479
     ” vera DC., 476
    Lavanga, 281
    Lavendelblumen, 476
    Lavender Flowers, 476
     ” oil of, 478
    Lawsonia alba Lam., 305
    Ledebouria hyacinthina Roth, 693
    LEGUMINOSÆ, 170
    Leinsamen, 97
    Lemon, 114
     ” essence of, 118
     ” grass, 725
    Leontodon hispidus L., 394
     ” Taraxacum L., 392
    Leontodonium, 394
    Lerp, 417
    Lettuce, garden, 396
     ” Opium, 399
     ” prickly, 396
    Leu-sung-kwo, 432
    Lewa, 51
    Liane à réglisse, 188
    =Lichen islandicus=, 737
     ” starch, 739
    LICHENES, 737
    Lichenic acid, 739
    Lichenin, 739
    Licheno-stearic acid, 739
    Lignum Aloës, 681
     ” Brasile, 216
     ” campechianum, 213
     ” floridum, 537
     ” =Guaiaci=, 100
     ” =Hæmatoxyli=, 213
     ” =Pterocarpi=, 199
     ” =Quassiæ=, 131
     ” sanctum, 100
     ” =Santali=, 599
     ” santalinum rubrum, 199
     ” Sassafras, 537
     ” Vitæ, 100
    LILIACEÆ, 679
    Limbu, 115
    Limon, 114
    Lin, 97
    LINEÆ, 97
    Linoleic acid, 99
    Linoxyn, 98
    Linseed, 97
    Linum usitatissimum L., 97
    Lippia citriodora Humb. Bonpl. et Kth., 726
    Liquidambar Altingiana Blume, 272. 277
     ” formosana Hance, 277
     ” imberbis Aiton, 271
     ” orientalis Miller, 271
     ” styraciflua L., 211. 271. 276
    Liquiritiæ radix, 179
     ” succus, 183
    Liquorice, extract of, 183
     ” indian, 188
     ” paste, 184
     ” root, 179
     ”   ”   russian, 181
      ”  ”   spanish, 181
     ” Solazzi, 184
     ” spanish, 183
    Lobelacrin, 400
    Lobelia inflata L., 399
    LOBELIACEÆ, 399
    Lobelianin, 400
    Lobelic acid, 400
    Lobeliin, 400
    Lobelina, 400
    Loblolly Pine, 607
    Lobus echinodes, 211
    LOGANIACEÆ, 428
    Logwood, 213
     ” extract of, 215
    Long Pepper, 582
    Lopez Root, 111
    Löwenzahnwurzel, 392
    Loxa Bark, 352
    Luban, 133. 137
     ” Bedowi, 134. 135
     ” Fasous, 138
     ” Maheri, 138
     ” Mascati, 138
     ” Mati, 135
     ” Meyeti, 135
     ” Sheheri, 134
    Lukrabo, 76
    Lupulin, 554
    Lupuline (alkaloid), 553
    Lupulinic Grains, 554
    Lupulite, 555
    Lupulus, 551
    Lycium, 35. 512
    LYCOPODIACEÆ, 731
    Lycopodium clavatum L., 731

    Mace, 508
     ” oil of, 507
    Macene, 509
    =Macis=, 508
    Macrotin, 16
    Magellanischer Zimmt, 17
    Magican, 595
    Magisterium Opii, 57
    MAGNOLIACEÆ, 17
    Mahā-tita, 473
    Mahmira, 3
    Mahwah tree, 728
    Maniguette, 651
    Makar tree, 135
    Malabathri folia, 533
    Malayan camphor, 516
    Male Fern, 733
    Malic acid in Euphorbium, 561
    Mallotus philippinensis Müller, 572
    MALVACEÆ, 92
    Mambroni chini, 4
    Mamiran, 4
    Mandāra, 425
    Mandeln, bittere, 247
     ” süsse, 244
    Mandobi, 187
    Mandragora microcarpa Bertoloni, 458
     ” officinarum ” 458
     ” vernalis ” 458
    Manduka-parni, 297
    Mangosteen, oil of, 86
    Mani, 187
    Manihot utilissima Pohl, 250
    =Manna=, 409
     ” Alhagi, 414
     ” Australian, 417
     ” Briançon, 416
     ” flake, 412
     ” Lerp, 417
     ” oak, 415
     ”-sugar, 412
     ” tamarisk, 414
     ” Tolfa, 412
    Mannite, 412. 730
     ” in Aconite, 10
      ” in ergot, 746
    ” in Taraxacum, 394
    Mapouria Ipecacuanha Müll. Arg., 370
    Maranta arundinacea L., 629
     ” indica Tussac, 629
    Margosa Bark, 154
    Margosic acid, 155
    Margosine, 155
    Marmelos, 130
    Marshmallow Root, 92
    Mastich, Alpha-resin, 164
     ” Beta-resin, 164
     ” Bombay, 165
     ” East India, 165
    =Mastiche=, 161
    Masticin, 164
    Maticin, 590
    Matico, 589
    Matricaria Chamomilla L., 358. 386
     ” suaveolens L., 386
    Maulbeeren, 544
    May Apple, 36
    Meadow Saffron, 699
    Mechoacan, 444
    Meconic acid, 40. 58. 63
    Meconidine, 59
    Meconine, 60
    Meconium, 42
    Meconoiosin, 60
    Meerrettig, 71
    Meerzwiebel, 690
    Melaleuca ericœfolia Smith, 280
     ” Leucadendron L., 277
     ” linariœfolia Smith, 280
     ” minor Smith, 278
    MELANTHACEÆ, 693
    Melegueta Pepper, 651
    Melezitose, 414. 416
    Melia Azadirachta L., 154
     ” Azedarach L., 154
     ” indica Brandis, 154
    MELIACEÆ, 154
    Melitose, 417
    Memeren, 4
    MENISPERMACEÆ, 23
    Menispermine, 33
    Menispermum Cocculus L., 31
    Menispermum palmatum Lam., 23
    Mentha crispa, 481
     ” piperita Hudson, 481
     ” Pulegium L., 486
     ” viridis L., 479
    Menthe poivrée, 481
     ” pouliot, 486
    Menthol, 483
    Mespilodaphne Sassafras Meissner, 539
    Mesquite gum, 239
    Meta-dioxybenzol, 323
    Metacopaivic acid, 91. 231
    Metastyrol, 274
    Methylamine in ergot, 746
    Mezereon Bark, 540
    Mimosa Catechu L., fol., 240
     ” Senegal L., 233
     ” Suma Kurz., 241
     ” Sundra Roxb., 240
    Mint, black, 484
     ” white, 484
    Mishmi Bitter, 3
    Mismalvas, 92
    Mohnkapseln, 40
    Mohr add, 135
    Mohr meddu, 134
    Mohrenkümmel, 331
    Molasses, 722
    Momiri, 4. 5
    Momordica Elaterium L., 292
    Monniera trifolia L., 114
    MORACEÆ, 544
    Morelle grimpante, 450
    Moriuga pterygosperma Gärtner, 73
    Morphine or Morphia, 41. 57. 63
     ” estimation, 63
    Morus alba L., 545
     ” nigra L., 544
    Moschuswurzel, 312
    Moss, Ceylon, 749
     ” Irish, 747
     ” Jaffna, 749
    Mosul gum, 178
    Mother Cloves, 286
    Mousse d’Irlande, 747
     ” d’Islande, 737
     ” perlée, 743
    Moutarde anglaise, 68
     ” blanche, 68
     ” grise, 64
     ” noire, 64
    Moutarde des Allemands, 71
    Mucuna cylindrosperma Welwitsch, 191
     ” pruriens DC., 189
     ” prurita Hkr., 189
    Mudar, 424
    Mudarine, 425
    Mulberries, 544
    Mulmul, 140
    Mundubi, 187
    Munjit, 438
    Mur, 140. 142
    Mûres, 544
    Murlo, 135
    Muscade, 502
     ” beurre de, 507
    Muskatblüthe, 508
    Muskatbutter, 507
    Muskatnuss, 502
    Muskatnussöl, 507
    Mustard, black, brown-red, 64
     ” oil of, 66
     ” white, 68
    Mustard paper, 68
    Mutterharz, 320
    Mutterkorn, 740
    Mutterkümmel, 331
    Mycose, 745
    Myrcia acris DC., 289
    Myristic acid, 507. 508. 663
     ”         ” from kokum, 87
     ”         ”   ”  orris, 663
    =Myristica=, 502
     ” fatua Houtt., 502. 506
     ” fragrans Houtt., 502
     ” moschata Thunb., 502
     ” officinalis L., 502
    MYRISTICEÆ, 502
    Myristicene, 506
    Myristicin, 506
    Myristicol, 506
    Myristin, 508
    Myrocarpus frondosus Allemão, 211
    Myronate of potassium, 66
    Myrosin, 66. 70
    Myrospermum Pereiræ Royle, 205
     ” toluiferum A. Rich., 202
    Myroxocarpin, 210
    Myroxylon Pereiræ Klotzsch, 205
     ” peruiferum L., 210
     ” punctatum Klotzsch, 202
     ” Toluifera, H.B.K, 202
    Myrrh, 140. 520
     ” arabian, 143. 146
    =Myrrha=, 140
    MYRTACEÆ, 277
    Myrtus Pimenta L., 287

    Narceine, 59. 63
    Narcotine, 57. 59. 62
    Nard, Indian, 312
    Nardostachys, 312
    Naringin, 117
    Narthex Asafœtida Falconer, 314
    Nataloïn, 687
    Nauclea Gambir Hunter, 335.
    Nectandra cinnamomoides Meissner, 534
     ” Cymbarum Ness, 540
     ” Rodiæi Schomburgk, 535
    Nectandria, 536
    Nelkenköpfe, 287
    Nelkenpfeffer, 287
    Nelkenstiele, 286
    Nephelium lappaceum L., 187
    Neroli Camphor, 127
     ” oil of, 126
    Nerprun, 157
    Neugewürz, 287
    Ngai Camphor, 518
    Ngan-si-hiang, 403
    Nhandi, 591
    Nicker seeds, 211
    Nicotiana multivalvis Lindley, 469
     ” persica Lindley, 469
     ” quadrivalvis Pursh, 469
     ” repanda Willd., 469
     ” Tabacum L., 466
    Nicotianin, 468
    Nicotine, 467
    Nieswurzel, 1
     ” weisse, 639
    Nightshade, deadly, 458
     ” woody, 450
    Nim Bark, 154
    Nimba, 154
    Nimbuka, 115
    Nipa fruticans Thunb., 721
    Noix d’Arec, 669
     ” de galle, 595
     ” Igasur, 431
     ” de muscade, 502
     ” vomique, 428
    Nunnari Root, 423
    Nutgalls, 595
    Nutmeg, 502
     ”    Butter, 507
    Nutmeg, expressed oil of, 507
    Nuts, Areca, 669
     ” Betel, 669
    Nux Arecæ, 669
     ” Betel, 669
     ” indica, 502. 503. 670
     ” Methel, 429
     ” moschata, 502
    =Nux Vomica=, 428

    Oak bark, 593
     ” galls, 595
     ” manna, 415
    Ognon marin, 690
    Oil, citronella, 726
     ” Geranium, 728
     ” ginger grass, 726
     ” lemon grass, 725
     ” Melissa, 725
     ” Namur or Nimar, 726
     ” palmarosa, 728
     ” rusa, 728
     ” Theobroma, 95
     ” Verbena, 725
    Okro, 94
    Olea cuspidata Wallich, 417
     ” europæa L., 417
     ” ferruginea Royle, 417
    OLEACEÆ, 409
    Oleic acid in almonds, 246
     ”    in Arachis, 187
    Olen, 4
    =Oleum Andropogonis=, 725
     ” =Arachis=, 186
     ” Aurantii florum, 126
     ” Bergamii, 121
     ” =Bergamottæ=, 121
     ” =Cacao=, 95
     ” cadinum, 623
     ” =Cajuputi=, 277
     ” Crotonis, 565
     ” =Garciniæ=, 86
     ” Graminis indici, 725
     ” Juniperi empyreumaticum, 623
     ” =Limonis=, 118
     ” Macidis, 507
     ” Mangostanæ, 86
     ” Menthæ piperitæ, 482
     ” Myristicæ expressum, 507
     ” =Neroli=, 126
     ” Nucistæ, 507
     ” =Olivæ=, 417
     ” =Rosæ=, 262
     ” =Sesami=, 473
     ” Spicæ, 479
     ” Theobromatis, 95
     ” Tiglii, 565
     ” Wittnebianum, 278
    =Olibanum=, 133. 141. 520
    Olive Oil, 417
    Olivenöl, 417
    Omam, 302. 726
    Ophelia angustifolia Don, 436
     ” Chirata Grisebach, 436
     ” densifolia Griseb., 438
     ” elegans Wight, 438
     ” multiflora Dalz., 438
    Ophelic acid, 437
    Ophioxylon serpentinum L., 4
    Opianic acid, 58
    Opianine, 58
    Opianyl (Meconin), 60
    =Opium=, 42
     ” Abkāri, 52
     ” Americanum, 61. 63
     ” of Asia Minor, 45. 60
     ” Chinese, 53
     ” Constantinople, 45
     ” East Indian, 50. 61. 62
     ” Egyptian, 47. 61
     ” European, 49. 60. 62
     ” Malwa, 50. 62
     ” Mosambik, 55
     ” Patna, 50. 53. 61
     ” Persian, 48. 61. 62
     ” salt, 57
     ” Smyrna, 45. 63
     ” thebaicum, 44
     ” Turkey, 45
     ” wax, 56
     ” Zambezi, 55
    Opoidia galbanifera Lindley, 320
    Opopanax, 327
    Opopanax Chironium Koch, 327
     ” persicum Boiss., 327
    Orange, Bigarade, 124
     ” bitter, 124
     ” Flower Water, 127
     ” Peel, 124
     ”  ”   oil of, 128
     ” Seville, 124
    ORCHIDACEÆ, 654
    Orchis, species yielding Salep, 654
    Ordeal Bean, 191
    Oreodaphne opifera Nees, 540
    Orge mondé ou perlé, 722
    Orizaba Root, 446
    Orme, 556
    Orinthogalum altissimum L., 693
    Ornus europæa Pers., 409
    Orris Camphor, 663
     ” Root, 660
    Otto of Rose, 262
    Oxyacanthine, 36
    Oxycannabin, 549
    Oxycopaivic acid, 231
    Oxylinoleic acid, 99
    Oxyphœnica, 225

    Pachyma Cocos, 714
    Palas, 197
    Palas Tree, 197
    Palma Christi Seeds, 567
    PALMÆ, 669
    Palmarosa Oil, 726
    Palmitic acid, 419
     ”        ”   in Arachis, 187
    Palo del soldado, 590. 591
    Panax quinquefolium L., 79. 593
    Papaver dubium L., 39
     ” officinale Gmelin, 40
    Papaver Rhœas L., 39
     ” setigerum DC., 40
     ” somniferum L., 39
    PAPAVERACEÆ, 39
    Papaverin, 42
    Papaverine, 42. 59
    Papaverosine, 42. 58
    Paracumaric acid, 689
    Paradieskörner, 651
    Paraffin, 266
    Paramenispermine, 33
    Para-oxybenzoic acid from aloes, 689
     ”                ”   ”   benzoin, 408
     ”                ”   ”   dragon’s blood, 674
     ”                ”   ”   Kamala, 575
    =Pareira Brava=, 25
     ”           ”    false, 28
     ”           ”    white, 30
     ”           ”    yellow, 30
    Paricine, 358
    Parigenin, 711
    Pariglina, 711
    Parillin, 711
    Pasewa, 51
    Passulæ majores, 159
    Patrinia scabiosaefolia Link, 380
    Pavot, 40
    Paytine, 359
    Peachwood, 213
    Pe-fuh-ling, 714
    Pea-nut oil, 186
    Pech, 619. 623
    Pelargonium Radula Aiton, 726
    Pelletierine, 291
    Pellitory Root, 383
    Pelosine in Bibiru, 536
     ” in Pareira, 28. 29
    Pennyroyal, 486
    Pennywort, Indian, 297
    Pepins de coings, 269
    Pepita, 432
    Pepper, black, 137. 576
     ”        ”    African, 589
     ” Cayenne, 452
     ” Guinea, 452
     ” Jamaica, 287
     ” long, 582
     ” pod or red, 452
     ” white, 581
    Peppermint, 481
    Peppermint camphor, 483
    Peppermint oil, 482
     ”          ”   chinese, 483
    Periploca indica Willd., 423
    Perlmoos, 747
    Persian berries, 158
    Pérusse, 612
    Perubalsam, 205
    Peruvian Bark, 338
    Peruvin, 209
    Petala Rhœados, 39
     ” Rosæ centifoliæ, 261
     ” gallicæ, 259
    Petit Grain, essence, 126. 128
    Peucedanum graveolens Hiern, 327
    Pfeffer, 576
     ” langer, 582
     ” spauischer, 452
    Pfefferminze, 481
    Pfriemenkraut, 170
    Phæoretin, 499. 500
    Pharbitis hispida Choisy, 448
    Pharbitis Nil Choisy, 448
    Pharbitisin, 449
    Phaseolus multiflorus Lam., 191
    Phœnix silvestris Roxb., 721
    Pholoroglucin from catechin, 423
     ” dragon’s blood, 675
     ” gamboge, 85
     ” hesperetin, 117
     ” kino, 196
     ” scoparin, 171
    Phu, 377
    Phyco-erythrin, 748
    Phyllinic acid, 256
    Physostigma venenosom Balfour, 191
    Physostigmine, 193
    Phytosterin, 193
    Pichurim Beans, 540
    Picræna excelsa Lindley, 131
    Picraconitine, 10
    Picrasma excelsa Planchon, 131
    Pictosclerotin, 745
    Picrotoxin, 32
    Pignons d’Inde, 565
    Pilocarpine, 113
    Pilocarpus pauciflorus St. Hilaire, 113
     ” pennatifolius Lam., 113
     ” Selloanus Engler, 113
    Pimaric acid, 607
    Piment des Anglais, 287
     ” jardins, 452
    Pimenta acris Wight, 289
     ” officinalis Lindley, 287
     ” Pimento Grisebach, 289
    Pimento, 287
    Pimienta de Tabasco, 287. 289
    Pimpinella Anisum L., 310
    Pin-lang, 669
    Pine, Loblolly, 604
     ” Scotch, 604
     ” swamp, 604
    Pinic acid, 607
    Pink Root, 433
    Pinus Abies L., 615
     ” australis Michaux, 604
     ” balsamea L., 612
     ” canadensis L., 612
     ” Cedrus L., 416
     ” Fraseri Pursh, 612
     ” Laricio Poiret, 604
     ” Larix L., 416. 609. 611
     ” Ledebourii Endl., 619
     ” maritima Poiret, 604
     ” palustris Miller, 604
     ” Picea L., 615
     ” Pinaster Solander, 604
     ” Pumilio Hänke, 614
     ” silvestris L., 604, 619
     ” Tæda L., 604
    Piper aduncum L., 591
     ” angustifolium Ruiz et Pavon, 589
     ” Betle L., 583. 669
     ” caninum A. Dietr., 588
     ” citrifolium Lam., 114
     ” Clusii DC., 589
     ” crassipes Korthals, 588
     ” Cubeba L. fil., 584
     ” lanceæfolium Humb. B. et K., 591
     ” longum L., 582. 591
     ” Lowong Bl., 588
     ” nigrum L., 576
     ” nodulosum Link, 114
     ” officinarum C. DC., 582
     ” ribesioides Wall., 588
    ” reticulatum L., 114
    PIPERACEÆ, 576
    Piperic acid, 580
    Piperidine, 580
    Piperin, 580
    Pipli-mul, 583. 584
    Pirus Cydonia L., 269
     ” glabra Boissier, 415
    Pissenlit, 392
    Pistache de terre, 186
    Pistacia atlantica Desf., 165
     ” cabulica Stocks, 165
     ” galls, 165
     ” Khinjuk Stocks, 165
     ” Lentiscus L., 161. 598
     ” palæstina Boissier, 165
     ” Terebinthus L., 165. 598
    Pitayo Bark, 345
    Pitch, black, 623
    ” Burgundy, 616
    Pitoya Bark, 359
    Pitoyine, 359
    Pix abietina, 616
     ” burgundica, 616
     ” liquida, 619
     ” navalis, 623
     ” nigra, 623
     ” sicca, 623
     ” solida, 623
    PLANTAGINEÆ, 490
    Plantago Cynops L., 490
     ” decumbens Forsk., 490
     ” Ispaghula Roxb., 490
     ” Psyllium L., 490
    Plaqueminier, 403
    Plocaria candida Nees, 749
    Plösslea floribunda Endl., 135
    Poaya, 375
    Pockholz, 100
    Pod pepper, 452
    Podisoma fuscum Duby, 628
    Podophyllin, 38
    Podophyllum peltatum L., 36
     ” resin, 37
    Pois à gratter, 189
     ” pouillieux, 189
     ” quéniques, 211
    Poivre, 576
     ” de Guinée, 452
     ” d’Inde, 452
     ” de la Jamaïque, 287
     ” long, 582
    Poix de Bourgogne, 616
     ” jaune, 616
     ” liquide, 619
     ” noire, 623
     ” des Vosges, 616
    Poke, Indian, 695
    Polei, 486
    Polychroit, 666
    Polygala Senega L., 77
    POLYGALEÆ, 77
    Polygalic acid, 78
    POLYGONACEÆ, 491
    Pomegranate Peel, 289
    Pomegranate-root Bark, 290
    Pomeranzenschale, 124
    Pontefract Cakes, 186
    Poppy Capsules, 40
     ” Heads, 40
     ” red, 38
    Portugal, oil of, 128
    Potato Starch, 633
    Potentilla Tormentilla Sibthorp, 81. 364
    Poudre des Capucins, 698
    Pouliot vulgaire, 486
    Prophetin, 294
    Prosopis glandulosa Torrey, 239
    Protium Icicariba Marchand, 152
    Protocatechuic acid, 171. 243. 637. 640
    Protopine, 59
    Provencer Oel, 417
    Pruneaux à médecine, 251
    Prunes, 251
    Prunier de St. Julien, 251
    Prunus Amygdalus Baill., 244. 247
     ” domestica L., 251
     ” Lauro-cerasus L., 254
     ” œconomica Borkh., 252
     ” serotina Ehrh., 253
     ” virginiana Miller, 253
    Prunus Padus L., 253
    Pseudaconine, 9
    Pseudaconitine, 9
    Pseudomorphine, 59. 62
    Psychotria emetica Mutis, 376
    Pteritannic acid, 735
    Pterocarpin, 201
    Pterocarpus angolensis DC., 202
     ” Draco L., 676
     ” erinaceus Poiret, 198
     ” indicus Willd., 194
     ” Marsupium Roxb., 194
     ” santalinus L., 199
    Ptychotis Ajowan DC., 302
     ” coptica DC., 302
    Puchury Beans, 540
    Pulas tree, 197
    Punica Granatum L., 289. 290
    Punicin, 291
    Punico-tannic acid, 291
    Purging cassia, 221
    Purga de Sierra Gorda, 447
    Purgirkörner, 565
    Purgo macho, 446
    Pūti-Karanja, 211
    Pyrèthre, 383
    Pyrocatechin from Areca nut, 671
     ”             ”   bearberry, 402
     ”             ”   cutch, 244
     ”             ”   kino, 196. 199
     ” in tar, 620. 622
    Pyroleum Oxycedri, 623
    Pyroligneous acid, 621

    Qinbil, 572. 573
    Qinnab, 548
    Qinnaq, 548
    Quassia amara L., 131. 133
     ” excelsa Swartz, 131
     ” Wood, 131
     ”   ”    Surinam, 133
    Quassiin, 132. 133
    Queckenwurzel, 729
    Quercetin, 244
    Quercite, 595
    Querci-tannic acid, 594
    Quercitrin, 260
    Quercus infectoria Olivier, 595
     ” lusitanica Webb, 595
     ” pedunculata Ehrh., 593
     ” persica Jaub. et Spach, 416
     ” Robur L., 593
     ” sessiliflora Sm., 593
     ” species yielding Manna, 416
     ” Vallonea Kotschy, 416
    Quetschen or Zwetschen, 252
    Quina blanca, 564 ” Caroni, 106
    Quinamine, 358
    Quince, Bengal, 129 ” Seeds, 269
    Quinicine, 359
    Quinidine, 358. 360
    Quinine, 359 ” iodo-sulphate, 360
    Quinoidine, 359
    Quinone or Kinone, 363
    Quinovic or Chinovic acid, 338. 364
    Quinovin or Chinovin, 364
    Quinquina, 338
    Quitch Grass, 729
    Quittensamen, 269

    =Radix Abri=, 188
     ” =Aconiti=, 8
     ” ” heterophylli, 14
     ” ” indica, 12
     ” Acori, 676
     ” Actææ racemosæ, 15
     ” =Althææ=, 92
     ” =Armoraciæ=, 71
     ” =Arnicæ=, 390
     ” =Belladonnæ=, 455
     ” Calami aromatici, 676
     ” =Calumbæ=, 23
     ” Chinæ, 712
     ”    ”    occidentalis, 714
     ” =Cimicifugæ=, 15
     ” Colchici, 699
     ” Columbo, 23
     ” Coptidis, 3
     ” dulcis, 179
     ” Ellebori nigri, 1
     ” Enulæ, 380
     ” Filicia, 733
     ” =Gentianæ=, 434
     ” =Glycyrrhizæ=, 179
     ” Graminis, 729
     ” Helenii, 380
     ” Hellebori albi, 693
     ” =Hellebori nigri=, 1
     ” =Hemidesmi=, 423
     ” =Inulae=, 380
     ” =Ipecacuanhæ=, 370
     ” =Jalapæ=, 443
     ” =Krameriæ=, 79
     ” Liquiritiæ, 179
     ” Lopeziana, 111
     ” Mechoacannæ, 444
     ” Melampodii, 1
     ” Pareiræ, 25
     ” Podophylli, 36
     ” Polygalæ Senegæ, 77
     ” pretiosa amara, 4
     ” =Pyrethri=, 383
     ” Ratanhiæ, 79
     ” =Rhei=, 491
     ” =Sarsaparillæ=, 703
     ” =Sassafras=, 537
     ” Satyrii, 654
     ” Scammoniæ, 438
     ” =Senegæ=, 77
     ” =Serpentariæ=, 591
     ” =Spigeliæ=, 433
     ” =Sumbul=, 312
     ” =Taraxaci=, 392
     ” =Toddaliæ=, 111
     ” Tylophoræ, 428
     ” =Valerianæ=, 377
     ” Verabri, 693
    Raifort, 71
    Raisins, 159
    RANUNCULACEÆ, 1
    Raphanus rusticanus, 71
    Rasamala, 272. 277
    Rasot or Rusot, 35
    Ratanhia des Antilles, 81
    Ratanhia-red, 80
     ”-tannic acid, 80
    Ratanhiawurzel, 79
    Ratanhin, 81
    Red-Cole, 71
    Red Poppy Petals, 39
     ” Sanders Wood, 199
    Réglisse, 179
     ” d’Amérique, 188
     ” suc de, 183
    Reseda lutea L., 67
     ” luteola L., 67
    =Resina Benzoë=, 403
     ” Draconis, 672
     ” =Guaiaci=, 103
     ” Jalapæ, 445
     ” Podophylli, 38
     ” Scammoniæ, 442
    Resorcin, 323. 326
    Retti, 188
    Rhabarber, 491
    Rhabarberin, 499
    Rhabarbic acid, 499
    RHAMNACEÆ, 157
    Rhamnegine, 159
    Rhamnetin, 159
    Rhamnetine, 158
    Rhamnine, 158
    Rhamnocathartin, 158
    Rhamnus cathartica L., 157
    Rhatany Ceará, 81
    Rhatania Root, 79
    Rhatany, Brazilian, 81
     ” New Granada, 82
     ” Pará, 81
     ” Payta, 79
     ” Peruvian, 79
     ” Savanilla, 82
    Rheïn, 499
    Rheo-tannic acid, 499
    Rheum australe L., 502
     ” compactum Don, 502
     ” Emodi Wallich, 502
     ” officinale Baillon, 492
     ” palmatum L., 492
     ” Rhaponticum L., 500
     ” undulatum L., 502
    Rheumic acid, 499
    Rheumin, 499
    Rhizoma Arnicæ, 390
    =Rhizoma Calami aromatici=, 676
     ” =Coptidis=, 3
     ” =Curcumæ=, 638
     ” =Filicis=, 733
     ” =Galangæ=, 641
     ” =Graminis=, 729
     ” =Iridis=, 660
     ” =Podophylli=, 36
     ” =Veratri albi=, 693
     ”       ”    =viridis=, 695
     ” =Zingiberis=, 635
    Rhœadine, 40. 42. 59. 63
    Rhœagenine, 59
    Rhubarb, 491
     ” Austrian, 502
     ” Canton, 496
     ” China, 496
     ” crown, 496
     ” East India, 496
     ” English, 500
     ” French, 501
     ” Muscovitic, 496
     ” Russian, 499
     ” Turkey, 496
    Rhubarb-bitter, 409
    Rhubarb-yellow, 409
    Rhus Bucki-amela Roxb., 167
     ” coriaria L., 169. 597
     ” semialata Murray, 167
    Richardsonia scabra Saint Hilaire, 376
    Ricinelaïdic acid, 570
    Ricinelaïdin, 570
    Ricinine, 570
    Ricinoleic acid, 570
    Ricinus communis L., 567.
    Röhrencassie, 221
    Rohrzucker, 714
    Rohun Bark, 156
    Romarin, 488
    Rosa acicularis Lindley, 268
     ” bifera Redouté, 261
     ” canina L., 265. 268
     ” centifolia L., 261
     ” cinnamomea L., 268
     ” damascena Miller, 262
     ” gallica L., 259
    ROSACEÆ, 244
    Rose, Attar of, 262
     ” Cabbage, 261
     ” Damask, 262
     ” Dog, 268
     ” leaves, 259
     ” Malloes, 272
     ” oil, 262
     ” pâle, 261
     ” petals, red, 259
     ” Provence, 261
     ” Provins, 259
     ” de Puteaux, 261
     ” rouge, 259
    Roseau aromatique, 676
    Rosemary, 488
    Rosenöl, 262
    Rosin, black, 607
     ” transparent, 607
     ” yellow, 607
    Rosinen, 159
    Rosmarinus officinalis L., 488
    Roetelia cancellata Rebent., 626
    Rotang, 672
    Rottlera tinctoria Roxb., 572
    Rottlerin, 575
    Rubia cordifolia L., 438
    RUBIACEÆ, 335
    Ruby Wood, 199
    Rusa ka tel, 726
    Rusot or Rasot, 35
    Rüsterrinde, 556
    RUTACEÆ, 106
    Rye, spurred, 740

    Sabadilla officinarum Brandt, 697
    Sabadillic acid, 699
    Sabadilline, 698
    Sabatrine, 699
    Sabine, 626
    Sabzī, 548
    =Saccharum=, 714
     ” chinense Roxb., 715
     ” officinarum L., 714
     ” violaceum Tussac, 716
    Saffron, 137. 663
     ” meadow, 699
    Safran, 663
    Safrene, 538
    Safrol, 538
    Sagapenum, 324
    Salai tree, 135
    Salep, 654
    Sālib misrī, 655
    Salicylic acid, 285
    Salix fragilis L., 416
    Salsepareille, 703
    Salseparin, 711
    Samadera indica Gärtner, 133
    Samara Ribes, 581
    Sambola, 312
    Sambucus canadensis L., 334
     ” Ebulus L., 334
     ” nigra L., 333
    Sandal-wood, 599
     ” red, 199
    Sandelholz, 599
     ” rothes, 199
    Sanders Wood, red, 199
    Sang-dragon, 672. 675
    =Sanguis Draconis=, 672. 675
    Sankira, 712
    Sant, 234
    Santal, 599
    Santal citrin, bois de, 599
    SANTALACEÆ, 599
    Santalic acid, 201
    Santalin, 201
    Santalum album L., 599. 602
     ” austro-caledonicum Vieill., 599
     ” cygnorum Miq., 599
     ” Freycinetianum Gand., 599
     ” lanceolatum Br., 599
     ” pyrularium A. Gray, 599
     ” rubrum, 199
     ” spicatum DC., 599. 601
     ” Yasi Seemann, 599
    =Santonica=, 387
    Santonin, 389
    Santoninic acid, 389
    Sap green, 159
    Sapan wood, 216. 521
    Sapin, 615
    Sapogenin, 78
    Saponin, 38
    Saptachhada, 421
    Saptaparna, 421
    Sārivā, 423
    Sarothamnus vulgaris Wimmer, 170
    Sarsa, 703
    Sarsaparilla, 703
     ” Brazilian, 709
     ” Guatemala, 709
     ” Guayaquil, 710
     ” Honduras, 709
     ” Indian, 423
     ” Jamaica, 709
     ” Lisbon, 709
     ” Mexican, 710
     ” Pará, 709
    Sarza, 703
    Sassafras Bark, 539. 540
     ” camphor, 538
     ” nuts, 540
     ” officinalis Nees, 537
     ” oil, 229. 538
     ” Root, 539
    Sassafrasholz, 537
    Sassafrid, 539
    Sassafrin, 539
    Sassarubin, 539
    Satyrii radix, 654
    Saussurea, 382
    Savin, 626
    =Scammonium=, 438
    Scammony, 438
     ” resin, 438
     ” root, 442
    Schierlingsblätter, 301
    Schierlingsfrucht, 299
    Schiffspech, 623
    Schlangenwurzel, 591
    Schœnanthus, 726. 728
    Schœnocaulon officinale A. Gray, 697
    Schusterpech, 623
    Scilla indica Roxb., 693
     ” maritima L., 690
    Scillaïn, 692
    Scillin, 692
    Scillipicrin, 692
    Scillitin, 692
    Scillitoxin, 692
    Sclererythrin, 745
    Sclerocrystallin, 745
    Sclerojodin, 745
    Scleromucin, 745
    Sclerotic acid, 745
    Sclerotium Clavus DC., 742
    Scleroxanthin, 745
    Scoparii cacumina, 170
    Scoparin, 171
    Scorodosma fœtidum Bunge, 314
    Scrape, 608
    Scrophularia frigida Boiss., 416
    SCROPHULARIACEÆ, 469
    Sebacic acid, 446
    =Secale cornutum=, 740
    Seidelbastrinde, 540
    Seigle ergoté, 740
    Semen Ajavæ, 302
     ” Ammi, 304
     ” Amomi, 287
     ” Anisi stellati, 20
     ” =Arecæ=, 211. 512. 669
     ” Badiani, 20
     ” =Bonducellæ=, 211
     ” Calabar, 191
     ” Carui, 304
     ” Cataputiæ, 567
     ” Cinæ, 387
     ” =Colchici=, 702
     ” Contra, 387
     ” Crotonis, 565
     ” =Cydoniæ=, 269
     ” =et folia Daturæ albæ=, 462
     ” =Fœni græci=, 172
     ” Guilandinæ, 211
     ” =Gynocardiæ=, 75
     ” =Ignatii=, 431
     ” =Ispaghulæ=, 490
     ” =Kaladanæ=, 448
     ” Lini, 97
     ” Nucis vomicæ, 428
     ” =Physostigmatis=, 191
     ” =Ricini=, 567
     ” =Sabadillæ=, 697
     ” sanctum, 387
     ” Santonicæ, 387
     ” =Sinapis nigræ=, 64
     ”       ”    =albæ=, 68
     ” =Staphisagriæ=, 5
     ” =Stramonii=, 461
     ” =Tiglii=, 565
     ” Zedoariæ, 387
    Semencine, 387
    Senapium, 65
    Séné, feuilles de, 216
    Senega Root, 77
    Senegin, 78
    Seneka Root, 77
    Senf, schwarzer, 64
     ” weisser, 68
    Senna, 216
    ” Alexandrian, 218
    ” Arabian, 219
    ” Bombay, 219
    ” East Indian, 219
    ” Moka, 219
    ” Tinnevelly, 219
    Sennacrol, 219
    Sennapicrin, 219
    Serapinum, 322. 324
    Serpentary Root, 591
    Serpentaire, 591
    Serronia Jaborandi Gaud., 114
    Sesamé Oil, 473
    SESAMEÆ, 473
    Sesamöl, 473
    Sesamum indicum DC., 473
    =Setæ Mucunæ=, 189
    Setwall, 378
    Sevenkraut, 626
    Sharkarā, 715
    Shi-mi, 716
    Shir-kisht, 415
    Siddhī, 548
    Sigia, 271
    Siliquæ, 172
    Silphium, 320
    Silva do Praya, 211
    Silvic acid, 607
    Simaruba excelsa DC., 131
    SIMARUBEÆ, 131
    Sinalbin, 69
    Sinapic acid, 70
    Sinapine, sulphate, 70
    Sinapis alba L., 68
    Sinapis erucoides L., 65
     ” juncea L., 68
     ” nigra L., 64
    Sinapoleic acid, 68
    Sinigrin, 66
    Sinistrin, 725
    Sireh grass, 725
    Sison Amomum L., 304
    Skimmi, 20
    Skuleïn, 692
    Slevogtia orientalis Grisebach, 438
    SMILACEÆ, 703
    Smilacin, 711
    Smilax aspera L., 703. 705
     ” Balbisiana Kunth, 714
     ” brasiliensis Sprgl., 714
     ” China L., 712
     ” cordato-ovata Rich., 705
     ” glabra Roxb., 712
     ” Japicanga Griseb., 714
     ” lanceæfolia Roxb., 712
     ” medica Schl. et Cham., 704
     ” officinalis Humb. Boupl. et Kth, 704. 707
     ” papyracea Poiret, 705
     ” Pseudo-China L., 714
     ” Purhampuy Ruiz, 705
     ” Schomburgkiana Kunth, 705
     ” syphilitica H.B. et K., 205
     ” syringoides Griseb., 714
     ” tamnifolia Michaux, 714
    Snake-root, black, 15
     ” Red River, 593
     ” Texan, 593
     ” Virginian, 592
    Socaloïn, 688
    Soffar, 234
    SOLANACEÆ, 450
    Solanicine, 451
    Solanidine, 451
    Solanine, 451
    Solanum Dulcamara L., 450
     ” nigrum L., 450
     ” tuberosum L., 633
    Solazzi Juice, 184
    Solenostemma Argel Hayne, 218. 220
    Somo, 20
    Sont, 234
    Sorghum saccharatum Pers., 721
    Sōyah or Suvā, 328
    Soymida febrifuga Jussieu, 156
    Spanish Juice, 183
    Sparteine, 171
    Spartium Scoparium L., 170
    Spearmint, 479
    Spermœdia Clavus Fries, 742
    Sphacelia segetum Léveillé, 742
    Sphærococcus confervoides Ag., 749
     ” lichenoides Agardh, 749
    Spigelia marilandica L., 433. 593
    Spike, oil of, 479
    Spikenard, 503
    Spina cervina, 157
    Spogel Seeds, 490
    Spoonwood, 402
    =Sporæ Lycopodii=, 731
    Springgurke, 292
    Spurred Rye, 740
    Squill, 690
    Squinanthus, 726, 728
    Squine, 712
    Squirting cucumber, 292
    Ssoffar, 234
    Ssont, 234
    Stacte, 137. 142
    Staphisagria, 6
    Staphisagrine, 7
    Staphisaigre, 5
    Star-Anise, 20
    Starch, Canna, 633
     ” chemistry of, 631
     ” Curcuma, 634
     ” Potato, 633
     ” structure of, 631
    Stavesacre, 5. 698
    Stearophanic acid, 33
    Stechapfelblätter, 459
    Stechapfelsamen, 461
    Steffensia citrifolia Kunth, 114
    Stephanskörner, 5
    STERCULIACEÆ, 95
    Sternanis, 20
    Stinkasant, 314
    =Stipes Dulcamaræ=, 450
    Stipites Caryophylli, 286
    Stizolobium pruriens Persoon, 189
    Stœchas arabica, 479
    Storax, liquid, 271
     ” true, 137. 141. 276
    Storesin, 274
    Stramonium, 459
     ” Seeds, 461
    Stringy-bark, 199
    =Strobili Humuli=, 551
    Strychnos colubrina L., 430
     ” Ignatii Bergius, 431
     ” Nux vomica L., 107. 428
     ” philippensis Blanco, 431
     ” Tieute Lesch., 430
    Sturmhut, 8
    Styphnic acid, 323
    STYRACEÆ, 403
    Styracin, 274
    Styrax Benzoin Dryander, 403
     ” calamita, 276
     ” Finlaysoniana Wallich, 404
     ” =liquidus=, 271
     ” officinalis L., 271. 276
     ” subdenticulata Miquel, 407
    Styrol, 274
     ” from Balsam of Tolu, 205
     ”   ”  Benzoin, 408
     ”   ”  Dragon’s Blood, 673
    Styroue, 274
    Suc d’Aloès, 679
    =Succus Glycyrrhizæ=, 182
    Succus Limonis, 116
    Sucre de canne, 714
    Sugar, 714
     ” beet root, 720
     ” maple, 72
     ” palm, 720
     ” Sorghum, 721
    Sumach, 169
    Sumbul root, 312
    Sumbulamic acid, 313
    Sumbulic acid, 313
    Sumbulin, 313
    Sumbulolic acid, 313
    Summitates Scoparii, 170
    Sureau, 333
    Surinjān, 701
    Suseman, 474
    Süssholz, 179
    Süssholzsaft, 183
    Sweet cane, 715
    Sweet Flag root, 676
     ” Gum, 276
     ” Wood bark, 561
    Swietenia febrifuga Willd., 156
    Sylvic acid, 607
    Synanthrose, 381
    Synaptase, 247
    Syrup, golden, 722
    Syrupus communis, 722
     ” hollandicus, 722

    Tabac, 466
    Tabakblätter, 466
    Ta-fung-tsze, 75
    Taj-pat, 533
    Talch or Talha, 234
    Tamarind, 224
    Tamarisk galls, 598
    =Tamarindi pulpa=, 224
    Tamarindus indica L., 224
     ” occidentalis Gärtner, 224
    Tamarix gallica mannifera Ehrenbg., 414
     ” orientalis L., 598
    Tang-hwang, 83
    Tannaspidic acid, 735
    Tannenharz, 616
    Tannic acid from galls, 597
    Tar, 619
     ” Archangel, 620
     ” beech, 623
     ” birch, 623
     ” Juniper, 623
     ” oil of, 623
     ” Stockholm, 620
     ” water, 622
    Taraxacerin, 394. 398
    Taraxarin, 394
    Taraxacum Dens-leonis Desfont., 392
     ” officinale Wiggers, 392
    Tecamez Bark, 359
    Teel Oil, 473
    Tephrosia Apollinea Delile, 221
    =Terebinthina argentoratensis=, 615
     ” =canadensis=, 612
     ” =chia=, 165
     ” cypria, 165
     ” lancina, 609
     ” =veneta=, 609
     ” =vulgaris=, 604
    Térébenthine d’Alsace, 615
     ” de Briançon, 609
     ” de Canada, 612
     ” de Chio, 165
     ” de Chypres, 165
     ” commune, 604
     ” du mélèze, 609
     ” du sapin, 615
     ” de Strasbourg, 615
     ” de Venise, 609
    Terpenthin, Chios, 165
     ” Cyprischer, 165
     ” gemeiner, 604
     ” Lärchen-, 609
     ” Strassburger, 615
     ” Venetianischer, 609
    Terra japonica (Catechu), 240. 335
     ” (Gambier), 335
    Tetranthera, 589
    Thalictrum foliolosum DC., 5
    Thalleioquin, 360
    Thallochlor, 739
    THALLOGENS, 737
    Thebaicine, 59
    Thebaine, 59, 62
    Thebenine, 59
    Thebolactic acid, 58
    Theobroma Cacao L., 95
     ” leiocarpum Bern., 95
     ” oil of, 95
     ” pentagonum Bern., 95
     ” Salzmannianum Bern., 95
    Theobromic acid, 97
    Theriaca, 44. 48. 439
    Thornapple, 459
    Thridace, 396
    Thus americanum, 603
     ” libycum, 325
     ” masculum, 133
     ” vulgare, 608
    Thyme, 487
     ” camphor, 487
     ” oil of, 487
    THYMELEÆ, 540
    Thymene, 488
    Thymiankraut, 487
    Thymol, 488
     ” from ajowan, 303
    Thymus vulgaris L., 487
    Tigala, 417
    Tiglinic acid, 386. 566. 699
    Tiglium officinale Klotzsch, 565
    Tikhur or Tikor, 634
    Til Oil, 473
    Tinospora cordifolia Miers, 33
     ” crispa Miers, 34
    Tita, 4
    Tobacco, 466
     ” Camphor, 468
     ” Indian, 469
    Toddalia aculeata Pers., 111
     ” lanceolata Lam., 111
    Toddy, 120
    Tolene, 205
    Tollkraut, 458
    Tolomane, 633
    Tolubalsam, 202
    Toluene, 622
    Toluifera Balsamum Miller, 202
    Toluol or Toluene, 204
     ” from Dragon’s Blood, 674
    Toulema, 633
    Tous-les-mois, 633
    Toute-épice, 287
    Toxiresin, 471
    Tragacanth, black, 177
     ” flake, 177
     ” syrian, 177
     ” vermicelli, 177
    =Tragacantha=, 174
    Traganthin, 178
    Treacle or Molasses, 722
    Trehala, 417. 746
    Trehalose, 417. 746
    Trigonella Fœnumgræcum L., 172
    Trimethylamine, in ergot, 746
     ” in hop, 553
    Triticin, 730
    Triticum repens L., 729
    Tropic acid, 457
    Tropine, 457
    =Tubera Chinæ=, 712
     ” Aconiti, 8
     ” Colchici, 699
     ” Salep, 654
    Tu-fuh-ling, 714
    Tung tree, 91
    Turanjabin, 414
    Turmeric, 638
    Turpentine, American, 606
     ” Bordeaux, 606
     ” Canadian, 612
     ” Chian, 165
     ” Cyprian, 165
     ” larch, 609
     ” Strassburg, 615
     ” Venice, 609
    Tylophora asthmatica Wight et Arnott, 427
    Tyrosin, 81

    Uëhka, 94
    ULMACEÆ, 566
    Ulmenrinde, 556
    Ulmin, 557
    Ulmus campestris Smith, 556
     ” fulva Michaux, 557
     ” montana With., 556
    UMBELLIFERÆ, 297
    Umbelliferone, 322
     ” from asafœtida, 319
     ”   ”  galbanum, 322
     ”   ”  mezereon, 541
     ”   ”  sumbul, 313
    Uncaria acida Roxb., 335
     ” Gambier Roxb., 335
    Urginea altissima Baker, 693
     ” indica Kunth, 693
     ” maritima Baker, 690
     ” Scilla Steinheil, 690
    Ursone, 402
    Uruk, 4
    Ushak, 325
    =Uvæ passæ=, 159

    Vaccinium Vitis-idæa L., 402
    Vacha, 677
    Valerian, japanese, 380
     ” Root, 377
    Valeriana angustifolia Tausch, 377
     ” celtica L., 378
     ” officinalis L., 377
     ” Phu L., 380
    VALERIANACEÆ, 377
    Valerianic acid, 379. 553
    Valerol, 553
    =Vanilla=, 657
     ” planifolia Andrews, 657
    Vanillic acid, 659
    Vanillin, 285. 409. 659
     ” artificial, 659
    Vanillon, 659
    Vars, 574
    Veilchenwurzel, 660
    Vellarin, 298
    Veratramarin, 695
    Veratric acid, 699
    Veratridine, 696
    Veratrine, 698
    Veratroïdine, 695. 696
    Veratrum album L., 693
     ” frigidum Schlechtendal, 695
     ” Lobelianum Bernhard, 695
     ” nigrum L., 695
     ” officinale Schlecht., 697
     ” Sabadilla Retzius, 697
     ” viride Aiton, 695
    Verek, 233
    Vermicelli, 177
    Verzino, 216
    Vetti-ver, 728
    Vikunia, 286
    Virginic acid, 79
    Vitis vinifera L., 159
    Vincetoxicum officinale Mönch, 79
    Virgin dip, 605
    Visha, 12
    Vola, 142

    Wacholderbeeren, 624
    Waltheria glomerata Presl., 591
    Waras, Wars, or Wurus, 572. 573. 576
    Wattle-tree, 237
    Waythorn, 157
    Weihrauch, 133
    White-Wood Bark, 73
    Whortleberry, red, 402
    Wild black Cherry bark, 253
    Winter’s Bark, 17
     ”         ”   false, 19
    Wintergreen, 402
    Wittedoorn, 237
    Wood Apple, 131. 239
     ” Oil, 88. 91. 229
    Wormseed, 387
    Wu-pei-tze, 169
    Wurmsamen, 387
    Wurus, 572. 573. 576

    Xanthoxylum elegans Engler, 114
    Ximenia americana L., 250
    Xylenol, 689
    Xylocassia, 529
    Xylocinnamomum, 529
    Xylole, 622
    Xylomarathrum, 537

    Yegaar tree, 35
    Yerba del soldado, 590
    Yuh-kin, 639

    Zadvar, 14
    Zanthoxylum, 111. 114
    Zeitlosenknollen, 699
    Zeitlosensamen, 702
    Zestes d’Oranges, 124
    Zimmt, 519
    Zingiber officinale Roscoe, 635
    ZINGIBERACEÆ, 635
    Zitwersamen, 387
    Zucker, 714
    Zwetschen, 252
    Zygia, 271. 272
    ZYGOPHYLLEÆ, 100

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